Experts and Doctors on dna repair in Netherlands


Locale: Netherlands
Topic: dna repair

Top Publications

  1. Nivard M, Pastink A, Vogel E. Mutational spectra induced under distinct excision repair conditions by the 3 methylating agents N-methyl-N-nitrosourea, N-methyl-N'-nitro-N-nitrosoguanidine and N-nitrosodimethylamine in postmeiotic male germ cells of Drosophila. Mutat Res. 1996;352:97-115 pubmed
    ..Based on the data obtained in the vermilion system with ENU, we propose, in addition, that the Drosophila alkyltransferase system repairs O6-methylguanine more efficiently than O6-ethylguanine. ..
  2. Muris D, Vreeken K, Carr A, Murray J, Smit C, Lohman P, et al. Isolation of the Schizosaccharomyces pombe RAD54 homologue, rhp54+, a gene involved in the repair of radiation damage and replication fidelity. J Cell Sci. 1996;109 ( Pt 1):73-81 pubmed
    ..It is hypothesized that the rhp54+ gene is involved in the recombinational repair of UV and X-ray damage and plays a role in the processing of replication-specific lesions. ..
  3. de Boer J, Andressoo J, de Wit J, Huijmans J, Beems R, van Steeg H, et al. Premature aging in mice deficient in DNA repair and transcription. Science. 2002;296:1276-9 pubmed
    ..We hypothesize that aging in TTD mice is caused by unrepaired DNA damage that compromises transcription, leading to functional inactivation of critical genes and enhanced apoptosis...
  4. van den Boom V, Citterio E, Hoogstraten D, Zotter A, Egly J, van Cappellen W, et al. DNA damage stabilizes interaction of CSB with the transcription elongation machinery. J Cell Biol. 2004;166:27-36 pubmed
    ..These findings are consistent with a model in which CSB monitors progression of transcription by regularly probing elongation complexes and becomes more tightly associated to these complexes when TCR is active. ..
  5. Luijsterburg M, Dinant C, Lans H, Stap J, Wiernasz E, Lagerwerf S, et al. Heterochromatin protein 1 is recruited to various types of DNA damage. J Cell Biol. 2009;185:577-86 pubmed publisher
    ..Our results show that HP1 proteins are important for DNA repair and may function to reorganize chromatin in response to damage. ..
  6. Durik M, Kavousi M, van der Pluijm I, Isaacs A, Cheng C, Verdonk K, et al. Nucleotide excision DNA repair is associated with age-related vascular dysfunction. Circulation. 2012;126:468-78 pubmed publisher
    ..Our study supports the concept that genomic instability contributes importantly to the development of cardiovascular disease. ..
  7. Vogel E, Nivard M, Ballering L, Bartsch H, Barbin A, Nair J, et al. DNA damage and repair in mutagenesis and carcinogenesis: implications of structure-activity relationships for cross-species extrapolation. Mutat Res. 1996;353:177-218 pubmed
    ..One main reason for this is the complication due to uneven distribution in the body, with effects on the dose in target tissues. The estimation can be impro ..
  8. Houtsmuller A, Rademakers S, Nigg A, Hoogstraten D, Hoeijmakers J, Vermeulen W. Action of DNA repair endonuclease ERCC1/XPF in living cells. Science. 1999;284:958-61 pubmed
  9. Marteijn J, Bekker Jensen S, Mailand N, Lans H, Schwertman P, Gourdin A, et al. Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response. J Cell Biol. 2009;186:835-47 pubmed publisher
    ..Although both lesions are processed by independent repair pathways and trigger signaling responses by distinct kinases, they eventually generate the same epigenetic mark, possibly functioning in DNA damage signal amplification. ..

More Information


  1. Smeenk G, Wiegant W, Vrolijk H, Solari A, Pastink A, van Attikum H. The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage. J Cell Biol. 2010;190:741-9 pubmed publisher
    ..Finally, we show that CHD4 promotes DSB repair and checkpoint activation in response to IR. Thus, the NuRD chromatin-remodeling complex is a novel regulator of DNA damage responses that orchestrates proper signaling and repair of DSBs. ..
  2. Agarwal S, van Cappellen W, Guénolé A, Eppink B, Linsen S, Meijering E, et al. ATP-dependent and independent functions of Rad54 in genome maintenance. J Cell Biol. 2011;192:735-50 pubmed publisher
    ..Finally, we show that ATP hydrolysis by Rad54 is required for the redistribution of DSB repair sites within the nucleus. ..
  3. Bergink S, Toussaint W, Luijsterburg M, Dinant C, Alekseev S, Hoeijmakers J, et al. Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex. J Cell Biol. 2012;196:681-8 pubmed publisher
    ..Furthermore, we show that RAD23 proteins rapidly dissociated from XPC upon binding to damaged DNA. Our data suggest that RAD23 proteins facilitate lesion recognition by XPC but do not participate in the downstream DNA repair process. ..
  4. Menoni H, Hoeijmakers J, Vermeulen W. Nucleotide excision repair-initiating proteins bind to oxidative DNA lesions in vivo. J Cell Biol. 2012;199:1037-46 pubmed publisher
  5. Drost J, van Boxtel R, Blokzijl F, Mizutani T, Sasaki N, Sasselli V, et al. Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer. Science. 2017;358:234-238 pubmed publisher
    ..We show that signature 30 can arise from germline NTHL1 mutations. ..