Experts and Doctors on dna repair in Japan


Locale: Japan
Topic: dna repair

Top Publications

  1. Seki S, Akiyama K, Watanabe S, Hatsushika M, Ikeda S, Tsutsui K. cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III. J Biol Chem. 1991;266:20797-802 pubmed
    ..The deduced amino acid sequence of mouse APEX nuclease exhibits a significant homology to those of exonuclease III of E. coli and ExoA protein of Streptococcus pneumoniae and an intensive homology with that of bovine AP endonuclease 1. ..
  2. Kobayashi I. Selfishness and death: raison d'être of restriction, recombination and mitochondria. Trends Genet. 1998;14:368-74 pubmed
    ..By extrapolation, the capacity of mitochondria to kill their host eukaryotic cell might have stabilized their initial symbiosis. ..
  3. Shima H, Suzuki M, Shinohara M. Isolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae. Genetics. 2005;170:71-85 pubmed
    ..This result suggests that the total amount of Xrs2 protein is a critical determinant for the function of the MRX complex especially with regard to telomere maintenance and meiotic DSB formation. ..
  4. Kiyohara E, Tamai K, Katayama I, Kaneda Y. The combination of chemotherapy with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma. Gene Ther. 2012;19:734-41 pubmed publisher
    ..These results suggest that the combination of chemotherapy with HVJ-E containing therapeutic molecules will provide a promising therapeutic strategy for patients bearing malignant tumors resistant to chemotherapeutic agents. ..
  5. Shimasaki T, Ishigaki Y, Nakamura Y, Takata T, Nakaya N, Nakajima H, et al. Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine. J Gastroenterol. 2012;47:321-33 pubmed publisher
    ..This study provides insight into the molecular mechanism of gemcitabine resistance and thus a new strategy for pancreatic cancer chemotherapy. ..
  6. Takagi M, Yoshida M, Nemoto Y, Tamaichi H, Tsuchida R, Seki M, et al. Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor. J Natl Cancer Inst. 2017;109: pubmed publisher
    ..Indeed, DDR-defective NB cell lines were sensitive to PARP inhibitors. Thus, PARP inhibitors represent candidate NB therapeutics. ..
  7. Saka Y, Fantes P, Yanagida M. Coupling of DNA replication and mitosis by fission yeast rad4/cut5. J Cell Sci Suppl. 1994;18:57-61 pubmed
    ..The restraint of mitosis until the completion of S phase is mediated by the cut5 protein, which can sense the state of chromosome duplication and negatively interacts with M phase regulators such as cdc25 and cdc2. ..
  8. Ikeda S, Ozaki K. Action of mitochondrial endonuclease G on DNA damaged by L-ascorbic acid, peplomycin, and cis-diamminedichloroplatinum (II). Biochem Biophys Res Commun. 1997;235:291-4 pubmed
    ..These nucleolytic properties of Endo G in vitro suggest its possible involvement in the maintenance of mtDNA by eliminating defective genomes from the multicopy pool. ..
  9. Kohji T, Hayashi M, Shioda K, Minagawa M, Morimatsu Y, Tamagawa K, et al. Cerebellar neurodegeneration in human hereditary DNA repair disorders. Neurosci Lett. 1998;243:133-6 pubmed
    ..These findings suggest that apoptotic cell death can be involved in the cerebellar degeneration in patients with hereditary defects in DNA repair mechanisms...

More Information

Publications150 found, 100 shown here

  1. Matsui E, Kawasaki S, Ishida H, Ishikawa K, Kosugi Y, Kikuchi H, et al. Thermostable flap endonuclease from the archaeon, Pyrococcus horikoshii, cleaves the replication fork-like structure endo/exonucleolytically. J Biol Chem. 1999;274:18297-309 pubmed
    ..Because the RF appears to be the intermediate structure, due to the arrest of the replication fork, the double strand breaks after the arrests of the replication forks are probably caused by phFEN...
  2. Tsurudome Y, Hirano T, Yamato H, Tanaka I, Sagai M, Hirano H, et al. Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles. Carcinogenesis. 1999;20:1573-6 pubmed
  3. Iwabuchi K, Hashimoto M, Matsui T, Kurihara T, Shimizu H, Adachi N, et al. 53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis. Genes Cells. 2006;11:935-48 pubmed
    ..These results demonstrate that the 53BP1-dependent repair pathway is important for survival of cells irradiated with IR during the G1 phase of the cell cycle. ..
  4. Osakabe K, Abe K, Yoshioka T, Osakabe Y, Todoriki S, Ichikawa H, et al. Isolation and characterization of the RAD54 gene from Arabidopsis thaliana. Plant J. 2006;48:827-42 pubmed
    ..In addition, the efficiency of somatic HR in the mutant plants was reduced relative to that in wild-type plants. Our findings point to an important role for Rad54 in HR repair in higher plants. ..
  5. Fu D, Wakasugi M, Ishigaki Y, Nikaido O, Matsunaga T. cDNA cloning of the chicken DDB1 gene encoding the p127 subunit of damaged DNA-binding protein. Genes Genet Syst. 2003;78:169-77 pubmed
    ..These results suggest that DDB1 is evolutionarily conserved in the primary structure and function, and may play a fundamental role in higher eukaryotes. ..
  6. Sano S, Chan K, Kira M, Kataoka K, Takagi S, Tarutani M, et al. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer Res. 2005;65:5720-9 pubmed
    ..These data suggest that Stat3 is required for survival and proliferation of keratinocytes following UVB exposure and that Stat3 is tightly regulated as part of a novel protective mechanism against UVB-induced skin cancer. ..
  7. Hasan K, Cheung C, Kaul Z, Shah N, Sakaushi S, Sugimoto K, et al. CARF Is a vital dual regulator of cellular senescence and apoptosis. J Biol Chem. 2009;284:1664-72 pubmed publisher
    ..We provide evidence that CARF plays a dual role in regulating p53-mediated senescence and apoptosis, the two major tumor suppressor mechanisms. ..
  8. Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Okubo M, et al. Association between genetic polymorphisms related to DNA repair or xenobiotic pathways and gastric premalignant conditions. Anticancer Res. 2011;31:1459-65 pubmed
    ..42, 95% CI=1.37-4.26, p=0.002, gastric ulcer: OR=2.18, 95% CI=1.11-4.29, p=0.025, duodenal ulcer: OR=2.62, 95% CI=1.15-6.00, p=0.023). Both the GSTT1 and GSTM1 null genotypes are associated with gastric pre-malignant conditions. ..
  9. Shimamoto T, Tanimura T, Yoneda Y, Kobayakawa Y, Sugasawa K, Hanaoka F, et al. Expression and functional analyses of the Dxpa gene, the Drosophila homolog of the human excision repair gene XPA. J Biol Chem. 1995;270:22452-9 pubmed
  10. Yamada H, Miyahara T, Kozuka H, Matsuhashi T, Sasaki Y. Potentiating effects of organomercuries on clastogen-induced chromosome aberrations in cultured Chinese hamster cells. Mutat Res. 1993;290:281-91 pubmed
  11. Kusano K, Sunohara Y, Takahashi N, Yoshikura H, Kobayashi I. DNA double-strand break repair: genetic determinants of flanking crossing-over. Proc Natl Acad Sci U S A. 1994;91:1173-7 pubmed
    ..We discuss how cooperation of the recQ gene product and the recJ gene product brings about double-strand break repair accompanied by flanking crossing-over. We also discuss how this reaction is related to repair of chromosome damages. ..
  12. Todo T, Takemori H, Ryo H, Ihara M, Matsunaga T, Nikaido O, et al. A new photoreactivating enzyme that specifically repairs ultraviolet light-induced (6-4)photoproducts. Nature. 1993;361:371-4 pubmed
    ..This is, to our knowledge, the first report of such photoreactivating activity specific for (6-4)photoproducts in any organism. ..
  13. Tan Y, Nakagawa Y, Akiyama K, Wakabayashi H, Sarker A, Seki S. cDNA cloning of rat major AP endonuclease (APEX nuclease) and analyses of its mRNA expression in rat tissues. Acta Med Okayama. 1996;50:53-60 pubmed
    ..The expression in thymus increased once at postnatal day 14, and then decreased. The developmental changes of Apex mRNA expression in testis and thymus suggest that APEX nuclease is involved in processes such as recombinational events. ..
  14. Yagi T, Matsumura Y, Sato M, Nishigori C, Mori T, Sijbers A, et al. Complete restoration of normal DNA repair characteristics in group F xeroderma pigmentosum cells by over-expression of transfected XPF cDNA. Carcinogenesis. 1998;19:55-60 pubmed
    ..These results demonstrate that excision repair defect in XP-F cells is fully corrected by over-expression of XPF cDNA alone, although only partial correction of the cells by XPF cDNA has been reported before. ..
  15. Hirano T, Higashi K, Sakai A, Tsurudome Y, Ootsuyama Y, Kido R, et al. Analyses of oxidative DNA damage and its repair activity in the livers of 3'-methyl-4-dimethylaminoazobenzene-treated rodents. Jpn J Cancer Res. 2000;91:681-5 pubmed
    ..6-fold and 1.6-fold, respectively. These experiments suggest that 3'-MeDAB increases 8-OH-Gua generation in rodent liver DNA and the 8-OH-Gua repair assay is a reliable marker of cellular oxidative stress induced by carcinogens...
  16. Cao X, Kambe F, Ohmori S, Seo H. Oxidoreductive modification of two cysteine residues in paired domain by Ref-1 regulates DNA-binding activity of Pax-8. Biochem Biophys Res Commun. 2002;297:288-93 pubmed
    ..These results demonstrated that oxidoreductive modification of Cys-45 and Cys-57 via Ref-1 plays a role in redox regulation of Pax-8 in living cells. ..
  17. Ikeda S, Kohmoto T, Tabata R, Seki Y. Differential intracellular localization of the human and mouse endonuclease III homologs and analysis of the sorting signals. DNA Repair (Amst). 2002;1:847-54 pubmed
    ..However, no difference in intracellular localization was observed among three isoforms of hNTH1 with different N-terminal sequences. ..
  18. Nishiwaki Y, Kobayashi N, Imoto K, Iwamoto T, Yamamoto A, Katsumi S, et al. Trichothiodystrophy fibroblasts are deficient in the repair of ultraviolet-induced cyclobutane pyrimidine dimers and (6-4)photoproducts. J Invest Dermatol. 2004;122:526-32 pubmed
    ..Our results suggest that there is no major difference in the repair defect between TTD and XP-D and that the cancer-free phenotype in TTD is unrelated to a DNA repair defect. ..
  19. Nakano T, Katafuchi A, Shimizu R, Terato H, Suzuki T, Tauchi H, et al. Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress. Nucleic Acids Res. 2005;33:2181-91 pubmed
    ..Analyses of the activity of CFEs from NER-proficient and NER-deficient human cells on Oxa-Sp DNA confirmed further the involvement of NER in the repair of nitrosative DNA damage. ..
  20. Sekine Suzuki E, Yu D, Kubota N, Okayasu R, Anzai K. Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells. Biochem Biophys Res Commun. 2008;377:341-345 pubmed publisher
    ..G2/M arrest by SFN, a typical response for cells exposed to ionizing radiation was also observed. Our new data indicate the clear induction of DSBs by SFN and a useful anti-tumor aspect of SFN through the induction of DNA DSBs. ..
  21. Salem A, Nakano T, Takuwa M, Matoba N, Tsuboi T, Terato H, et al. Genetic analysis of repair and damage tolerance mechanisms for DNA-protein cross-links in Escherichia coli. J Bacteriol. 2009;191:5657-68 pubmed publisher
    ..Finally, DNA glycosylases mitigate azaC toxicity, independently of the repair of DPCs, presumably by removing 5-azacytosine or its degradation product from the chromosome. ..
  22. Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Okubo M, et al. Effect of genetic polymorphisms related to DNA repair and the xenobiotic pathway on the prognosis and survival of gastric cancer patients. Anticancer Res. 2011;31:705-10 pubmed
    ..019). XRCC1 codon 194 Trp carrier status is correlated with more aggressive biological behavior of GC, such as venous invasion, and the GSTT1 null genotype is associated with better survival in GC patients. ..
  23. Sano N, Rajjou L, North H, Debeaujon I, Marion Poll A, Seo M. Staying Alive: Molecular Aspects of Seed Longevity. Plant Cell Physiol. 2016;57:660-74 pubmed publisher
  24. Zhang Y, Matsuzaka T, Yano H, Furuta Y, Nakano T, Ishikawa K, et al. Restriction glycosylases: involvement of endonuclease activities in the restriction process. Nucleic Acids Res. 2017;45:1392-1403 pubmed publisher
    ..These results support generalization of the concept of restriction–modification system to the concept of self-recognizing epigenetic system, which combines any epigenetic labeling and any DNA damaging. ..
  25. Miyamoto T. High frequency of spontaneous Minute mutations detected in the F1 progeny of interstrain matings between a recombination-defective mei-9L1 and the y w m f/sc8(y+) Y BS; dp strain of Drosophila melanogaster. Mutat Res. 1990;243:207-12 pubmed
  26. Nakagawa K, Tada M, Morita T, Utsunomiya J, Ishikawa T. Immunohistochemical detection of 4-hydroxyaminoquinoline 1-oxide-DNA adducts in mouse tissues in vivo. J Natl Cancer Inst. 1988;80:419-25 pubmed
    ..The intensity of immunohistochemical staining correlated well with numbers of 4HAQO-DNA adducts measured by the radiolabeling technique...
  27. Kamiuchi S, Saijo M, Citterio E, de Jager M, Hoeijmakers J, Tanaka K. Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair. Proc Natl Acad Sci U S A. 2002;99:201-6 pubmed
    ..The hydrogen peroxide-induced translocation of CSA was also CSB dependent. These findings establish a link between TCR and the nuclear matrix mediated by CSA. ..
  28. Ogi T, Shinkai Y, Tanaka K, Ohmori H. Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene. Proc Natl Acad Sci U S A. 2002;99:15548-53 pubmed
    ..Thus, our results indicate that Polkappa plays an important role in suppressing mutations at DNA lesions generated by B[a]P. ..
  29. Arai T, Kelly V, Komoro K, Minowa O, Noda T, Nishimura S. Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA. Cancer Res. 2003;63:4287-92 pubmed
    ..These results showed that inactivation of the Ogg1 gene leads to a higher risk of cancer because cells with accumulated 8-OH-G still retain the ability to proliferate, leading to an increase in the mutation frequency. ..
  30. Takahashi A, Ohnishi T. The significance of the study about the biological effects of solar ultraviolet radiation using the Exposed Facility on the International Space Station. Biol Sci Space. 2004;18:255-60 pubmed
  31. Kawamoto T, Araki K, Sonoda E, Yamashita Y, Harada K, Kikuchi K, et al. Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis. Mol Cell. 2005;20:793-9 pubmed
    ..Our findings identify a DNA polymerase that carries out DNA synthesis for physiological HR and provides evidence that a single DNA polymerase can play multiple cellular roles. ..
  32. Sugawara T, Oguro H, Negishi M, Morita Y, Ichikawa H, Iseki T, et al. FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells. Exp Hematol. 2010;38:696-706 pubmed publisher
    ..Our findings define Fus as a novel regulator of self-renewal and radioprotection of HSCs and also implicate it in stress-resistance and maintenance of the genomic integrity of HSCs. ..
  33. Hirose K, Shimoda N, Kikuchi Y. Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin. Epigenetics. 2013;8:899-906 pubmed publisher
    ..Taken together, our findings illustrate that the transient reduction of 5mC and 5hmC in dedifferentiated cells is associated with active demethylation during regeneration of zebrafish fin. ..
  34. Matsubayashi H, Yamamoto M. REC, a new member of the MCM-related protein family, is required for meiotic recombination in Drosophila. Genes Genet Syst. 2003;78:363-71 pubmed
    ..These analyses suggest that the rec gene has no, or only a minor, role in DNA repair and recombination in somatic cells. ..
  35. Sekine E, Okada M, Matsufuji N, Yu D, Furusawa Y, Okayasu R. High LET heavy ion radiation induces lower numbers of initial chromosome breaks with minimal repair than low LET radiation in normal human cells. Mutat Res. 2008;652:95-101 pubmed publisher
    ..These results at the chromosome level substantiate and extend the notion that high LET radiation produces complex-type DNA double strand breaks (DSBs). ..
  36. Shinohara A, Ogawa H, Ogawa T. Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell. 1992;69:457-70 pubmed
    ..Rad51 protein is also homologous to a meiosis-specific Dmc1 protein of S. cerevisiae. ..
  37. Iwasaki H, Shiba T, Makino K, Nakata A, Shinagawa H. Overproduction, purification, and ATPase activity of the Escherichia coli RuvB protein involved in DNA repair. J Bacteriol. 1989;171:5276-80 pubmed
    ..RuvB protein had a stronger affinity to ADP than to ATP and weak ATPase activity. The results suggest that the weak ATPase activity of RuvB protein is at least partly due to end product inhibition by ADP. ..
  38. Yamashita T, Nakahata T. Current knowledge on the pathophysiology of Fanconi anemia: from genes to phenotypes. Int J Hematol. 2001;74:33-41 pubmed
    ..Clarifying the molecular basis of this disease may provide new insights into the pathogenesis of bone marrow failure syndromes and myeloid malignancies. ..
  39. Moriyama H, Sasamoto H, Kambara T, Matsubara N, Ikeda M, Baba S, et al. E2F-4 mutation in hereditary non-polyposis colorectal cancer. J Exp Clin Cancer Res. 2002;21:185-9 pubmed
    ..The frequency of the E2F-4 mutation in HNPCC was comparable with that in sporadic CRC with MSI-H. E2F-4 was considered to be one of the important target genes responsible for the carcinogenesis of HNPCC. ..
  40. Hazawa M, Hosokawa Y, Monzen S, Yoshino H, Kashiwakura I. Regulation of DNA damage response and cell cycle in radiation-resistant HL60 myeloid leukemia cells. Oncol Rep. 2012;28:55-61 pubmed publisher
    ..These results reveal that radiation-resistant strains have a high repair capacity, and inhibition of the repair system at an early stage is an effective strategy in the second round of radiation therapy. ..
  41. Ito H, Matsuo K, Hamajima N, Mitsudomi T, Sugiura T, Saito T, et al. Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk. Carcinogenesis. 2004;25:1395-401 pubmed
    ..936) and that with light smoking was 2.67 (95% CI 1.00-7.68, P = 0.049). These results suggest that APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of lung cancer attributable to cigarette smoking exposure. ..
  42. Nishiwaki T, Kobayashi N, Iwamoto T, Yamamoto A, Sugiura S, Liu Y, et al. Comparative study of nucleotide excision repair defects between XPD-mutated fibroblasts derived from trichothiodystrophy and xeroderma pigmentosum patients. DNA Repair (Amst). 2008;7:1990-8 pubmed publisher
    ..Since TFIIH is a repair/transcription factor, TTD-specific alterations of TFIIH possibly result in transcriptional defects, which might be implication for the lack of increased incidence of skin cancers in TTD patients. ..
  43. Ono Y, Watanabe M, Inoue Y, Ohmoto T, Akiyama K, Tsutsui K, et al. Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains. Brain Res Dev Brain Res. 1995;86:1-6 pubmed
    ..However, the present results suggested that APEX/Ref-1 gene product can interact with AP-1 binding proteins in brain, especially in the hippocampal formation, to regulate some brain functions by redox-activation. ..
  44. Nakane H, Takeuchi S, Yuba S, Saijo M, Nakatsu Y, Murai H, et al. High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene. Nature. 1995;377:165-8 pubmed
    ..The XPA-deficient mice may provide a good in vivo model to study the high incidence of skin carcinogenesis in group A XP patients. ..
  45. Tauchi H. Positional cloning and functional analysis of the gene responsible for Nijmegen breakage syndrome, NBS1. J Radiat Res. 2000;41:9-17 pubmed
    ..Functional analysis of the NBS1 protein is in progress and it should provide further clues to understanding the repair mechanism of radiation-induced DNA double-strand breaks. ..
  46. Yamamoto T, Mori Y, Ishibashi T, Uchiyama Y, Sakaguchi N, Furukawa T, et al. Characterization of Rad6 from a higher plant, rice (Oryza sativa L.) and its interaction with Sgt1, a subunit of the SCF ubiquitin ligase complex. Biochem Biophys Res Commun. 2004;314:434-9 pubmed
    ..The Rad6 pathway for repair or the proteasome system may thus require Sgt1 as ubiquitin-conjugating enzyme...
  47. Asakawa H, Koizumi H, Koike A, Takahashi M, Wu W, Iwase H, et al. Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins. Breast Cancer Res. 2010;12:R17 pubmed publisher
    ..Our results suggested an importance of evaluation of DDR competence to predict breast cancer chemosensitivity, and merits further studying into its usefulness in exclusion of non-responder patients. ..
  48. Kuno T, Matsubara N, Tsuda S, Kobayashi M, Hamanaka M, Yamagishi D, et al. Alterations of the base excision repair gene MUTYH in sporadic colorectal cancer. Oncol Rep. 2012;28:473-80 pubmed publisher
    ..However, it is possible that unknown mutations of regions not analyzed in this study and epigenetic changes of the promoter region of MUTYH may contribute to the disease. ..
  49. Tsukamoto Y, Kato J, Ikeda H. Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature. 1997;388:900-3 pubmed
    ..We propose that Sir proteins act with Hdf1 to alter broken DNA ends to create an inactivated chromatin structure that is essential for the rejoining of DNA ends. ..
  50. Harada Y, Shiomi N, Koike M, Ikawa M, Okabe M, Hirota S, et al. Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene. Mol Cell Biol. 1999;19:2366-72 pubmed
    ..Our in vitro studies showed that primary embryonic fibroblasts isolated from the xpg-deficient mice underwent premature senescence and exhibited the early onset of immortalization and accumulation of p53. ..
  51. Fujimoto M, Leech S, Theron T, Mori M, Fawcett H, Botta E, et al. Two new XPD patients compound heterozygous for the same mutation demonstrate diverse clinical features. J Invest Dermatol. 2005;125:86-92 pubmed
    ..Despite these similarities between our two patients, their clinical features are quite different and the clinical severity correlates with other cellular responses to ultraviolet irradiation. ..
  52. Kano M, Matsushita K, Rahmutulla B, Yamada S, Shimada H, Kubo S, et al. Adenovirus-mediated FIR demonstrated TP53-independent cell-killing effect and enhanced antitumor activity of carbon-ion beams. Gene Ther. 2016;23:50-6 pubmed publisher
    ..Our findings indicated the feasibility of the combination of Ad-FIR with DNA damaging agents for future esophageal cancer treatment. ..
  53. Araki M, Masutani C, Takemura M, Uchida A, Sugasawa K, Kondoh J, et al. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J Biol Chem. 2001;276:18665-72 pubmed
    ..CEN2 has been shown to play an important role in centrosome duplication. Thus, those findings suggest that the XPC-CEN2 interaction may reflect coupling of cell division and NER. ..
  54. Aono N, Sutani T, Tomonaga T, Mochida S, Yanagida M. Cnd2 has dual roles in mitotic condensation and interphase. Nature. 2002;417:197-202 pubmed
    ..These interphase and mitotic defects provide insight into the mechanistic role of non-SMC subunits that interact with the globular SMC domains in the heteropentameric holocomplex. ..
  55. Uchida T, Miyawaki M, Kinashi H. Chromosomal arm replacement in Streptomyces griseus. J Bacteriol. 2003;185:1120-4 pubmed
    ..Frequent homologous recombinations in Streptomyces strains suggest that telomere deletions can usually be repaired by recombinational DNA repair functioning between the intact and deleted TIR sequences on the same chromosome. ..
  56. Motoyama N, Naka K. DNA damage tumor suppressor genes and genomic instability. Curr Opin Genet Dev. 2004;14:11-6 pubmed
  57. Nojima K, Hochegger H, Saberi A, Fukushima T, Kikuchi K, Yoshimura M, et al. Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res. 2005;65:11704-11 pubmed
  58. Uchida N, Mitani H, Todo T, Ikenaga M, Shima A. Photoreactivating enzyme for (6-4) photoproducts in cultured goldfish cells. Photochem Photobiol. 1997;65:964-8 pubmed
    ..These results suggested the presence of (6-4) photolyase in cultured goldfish cells as in Drosophila, Xenopus and Crotalus. ..
  59. Kikuchi K, Taniguchi Y, Hatanaka A, Sonoda E, Hochegger H, Adachi N, et al. Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends. Mol Cell Biol. 2005;25:6948-55 pubmed
    ..We conclude that Fen-1 eliminates heterologous sequences at DNA damage site and facilitates DNA repair by HR. ..
  60. Hara T, Omura Minamisawa M, Kang Y, Cheng C, Inoue T. Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed. Int J Radiat Oncol Biol Phys. 2008;71:1485-95 pubmed publisher
    ..A combination treatment of flavopiridol with radiation has the potential to conquer the radioresistance of malignant tumors induced by the genetic alteration of p53 or bcl-2. ..
  61. Seki S, Hatsushika M, Watanabe S, Akiyama K, Nagao K, Tsutsui K. cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III. Biochim Biophys Acta. 1992;1131:287-99 pubmed
  62. Takahashi N, Yoshikura H, Kobayashi I. An Escherichia coli strain, BJ5183, that shows highly efficient conservative (two-progeny) DNA double-strand break repair of restriction breaks. Gene. 2003;303:89-97 pubmed
    ..BJ5183 carries a mutation in the endA gene, which codes for Endonuclease I. An endA mutation conferred a higher double-strand break-repair activity to a recBC sbcA mutant strain. ..
  63. Liu Y, Nakahara T, Miyakoshi J, Hu D, Nakane A, Abe Y. Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells. J Radiat Res. 2007;48:13-20 pubmed
    ..Thus the present results showed a correlation between NF-kappaB activation and the repair of sublethal damage in split-dose irradiation. ..
  64. Shikazono N, O Neill P. Biological consequences of potential repair intermediates of clustered base damage site in Escherichia coli. Mutat Res. 2009;669:162-8 pubmed publisher
    ..We propose that, when either base lesion is initially excised from a bistranded base damage site, the remaining base lesion will only rarely be converted into an AP site or a single strand break in vivo. ..
  65. Tomida J, Itaya A, Shigechi T, Unno J, Uchida E, Ikura M, et al. A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair. Nucleic Acids Res. 2013;41:6930-41 pubmed publisher
    ..Collectively, these data reveal new aspects of the interplay between regulation of ATR-ATRIP kinase and activation of the FA pathway. ..
  66. Nagai A, Saijo M, Kuraoka I, Matsuda T, Kodo N, Nakatsu Y, et al. Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein. Biochem Biophys Res Commun. 1995;211:960-6 pubmed
    ..These results suggest that the XPA/ERCC1 interaction may participate in damage-recognition as well as in incision at the 5' site of damage during nucleotide excision repair. ..
  67. Johzuka K, Ogawa H. Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Genetics. 1995;139:1521-32 pubmed
    ..Using a two-hybrid system, we found that Mre11 interacts with Rad50 and itself in vivo. These results suggest that Mre11 and Rad50 proteins work in a complex in DSB formation and DNA repair during vegetative growth. ..
  68. Yamagata Y, Kato M, Odawara K, Tokuno Y, Nakashima Y, Matsushima N, et al. Three-dimensional structure of a DNA repair enzyme, 3-methyladenine DNA glycosylase II, from Escherichia coli. Cell. 1996;86:311-9 pubmed
    ..The structure of the active site implies broad substrate specificity and simple N-glycosylase activity. ..
  69. Fujimoto H, Hirukawa Y, Tani H, Matsuura Y, Hashido K, Tsuchida K, et al. Integration of the 5' end of the retrotransposon, R2Bm, can be complemented by homologous recombination. Nucleic Acids Res. 2004;32:1555-65 pubmed
    ..These findings suggest that the host's mechanism for DNA repair may be necessary for the integration of the 5' end of R2Bm and that R2Bm protein may only have the ability to integrate the 3' end of the element by TPRT. ..
  70. Tome Y, Uehara F, Miwa S, Yano S, Mii S, Efimova E, et al. Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein. Anticancer Res. 2016;36:3821-6 pubmed
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