Experts and Doctors on dna primers in Japan

Summary

Locale: Japan
Topic: dna primers

Top Publications

  1. Niimi M, Nakai Y, Aida Y. Nucleotide sequences and the molecular evolution of the DMA and DMB genes of the bovine major histocompatibility complex. Biochem Biophys Res Commun. 1995;217:522-8 pubmed
  2. Hayasaka K, Himoro M, Sawaishi Y, Nanao K, Takahashi T, Takada G, et al. De novo mutation of the myelin P0 gene in Dejerine-Sottas disease (hereditary motor and sensory neuropathy type III). Nat Genet. 1993;5:266-8 pubmed
    ..The results strongly suggest that a de novo dominant mutation of the P0 gene is responsible for at least some sporadic cases of Dejerine-Sottas disease. ..
  3. Guo M, Mori E, Xu J, Mori T. Identification of Fas antigen associated with apoptotic cell death in murine ovary. Biochem Biophys Res Commun. 1994;203:1438-46 pubmed
    ..The data obtained indicate that apoptotic cell death of oocytes seemed to be associated with internucleosomal DNA fragmentation regulated by Fas molecule expressed in atretic ovarian follicles. ..
  4. Kawai J, Suzuki H, Taga C, Hara A, Watanabe S. Correspondence of RLGS-M spot behavior with tissue expression on mouse homologue of DP1/TB2 gene. Biochem Biophys Res Commun. 1995;213:967-74 pubmed
    ..These results indicate that the mouse DP1/TB2 gene is expressed corresponding to its RLGS-M spot behavior which is related to its methylation condition. ..
  5. Kitagawa K, Masumoto H, Ikeda M, Okazaki T. Analysis of protein-DNA and protein-protein interactions of centromere protein B (CENP-B) and properties of the DNA-CENP-B complex in the cell cycle. Mol Cell Biol. 1995;15:1602-12 pubmed
  6. Ishibashi M, Ang S, Shiota K, Nakanishi S, Kageyama R, Guillemot F. Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev. 1995;9:3136-48 pubmed
    ..These results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis. ..
  7. Aizawa H, Sutoh K, Yahara I. Overexpression of cofilin stimulates bundling of actin filaments, membrane ruffling, and cell movement in Dictyostelium. J Cell Biol. 1996;132:335-44 pubmed
    ..D. discoideum cofilin may sever actin filaments in vivo and induce bundling of the filaments in the presence of cross-linking proteins so as to generate contractile systems involved in membrane ruffling and cell movement. ..
  8. Isami S, Kishikawa H, Araki E, Uehara M, Kaneko K, Shirotani T, et al. Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway. Diabetologia. 1996;39:412-20 pubmed
    ..This effect could be explained by the potency of bradykinin to upregulate the insulin receptor tyrosine kinase activity which stimulates phosphorylation of IRS-1, followed by GLUT4 translocation. ..
  9. Ikeda J, Kaneda S, Kuwabara K, Ogawa S, Kobayashi T, Matsumoto M, et al. Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150. Biochem Biophys Res Commun. 1997;230:94-9 pubmed
    ..Furthermore, tissue specificity of expression of ORP150 was quite similar to that of GRP78. These findings suggest that ORP150 participates in quality control of proteins in the ER in response to diverse environmental stresses. ..

More Information

Publications201 found, 100 shown here

  1. Kanzaki H, Ueda M, Morishita Y, Akiyama H, Arata J, Kanzaki S. Producibility of exfoliative toxin and staphylococcal coagulase types of Staphylococcus aureus strains isolated from skin infections and atopic dermatitis. Dermatology. 1997;195:6-9 pubmed
    ..Strains of Staphylococcus aureus which cause staphylococcal scalded skin syndrome (SSSS) and bullous impetigo secrete exfoliative toxin (ET). Two antigenically distinct serotypes of ET, ETA and ETB, have been reported...
  2. Uchide T, Masuda H, Mitsui Y, Saida K. Gene expression of vasoactive intestinal contractor/endothelin-2 in ovary, uterus and embryo: comprehensive gene expression profiles of the endothelin ligand-receptor system revealed by semi-quantitative reverse transcription-polymerase chain reactio. J Mol Endocrinol. 1999;22:161-71 pubmed
    ..In embryonic development, VIC gene expression sharply increased between 11 and 15 days post coitus and decreased after birth, suggesting an involvement in the later stages of embryonic development. ..
  3. Konishi M, Tsuduku S, Haritani M, Murakami K, Tsuboi T, Kobayashi C, et al. An epidemic of caprine arthritis encephalitis in Japan: isolation of the virus. J Vet Med Sci. 2004;66:911-7 pubmed
    ..Goats inoculated with the culture fluid became antibody positive. These results suggested that a CAEV-infected goat had been introduced accidentally to the farm and that subclinical infection occurred among the flock. ..
  4. Sakai T, Kawai T, Kato I. Isolation and characterization of a fucoidan-degrading marine bacterial strain and its fucoidanase. Mar Biotechnol (NY). 2004;6:335-46 pubmed
    ..5 to 8.0 and temperature 30 degrees to 35 degrees C. The enzyme was activated by calcium ions, and maximum activity was observed in the presence of greater than 30 mM calcium ion. ..
  5. Kobayashi H, Nakajima H, Shimizu Y, Eguchi M, Hata E, Yamamoto K. Macrolides and lincomycin susceptibility of Mycoplasma hyorhinis and variable mutation of domain II and V in 23S ribosomal RNA. J Vet Med Sci. 2005;67:795-800 pubmed
    ..The strain selected by lincomycin showed an additional point mutation of A2062G selected by tylosin...
  6. Suzuki Y, Ando F, Ohsawa I, Shimokata H, Ohta S. Association of alcohol dehydrogenase 2*1 allele with liver damage and insulin concentration in the Japanese. J Hum Genet. 2006;51:31-7 pubmed
  7. Sasaki T, Poudel S, Isawa H, Hayashi T, Seki N, Tomita T, et al. First molecular evidence of Bartonella quintana in Pediculus humanus capitis (Phthiraptera: Pediculidae), collected from Nepalese children. J Med Entomol. 2006;43:110-2 pubmed
    ..quintana DNA sequences were detected in both head and body lice from two children as well as in body lice derived from two other children. These results demonstrate that head lice may also play a role in the transmission of trench fever...
  8. Kumagai K, Nimura Y, Mizota A, Miyahara N, Aoki M, Furusawa Y, et al. Arpc1b gene is a candidate prediction marker for choroidal malignant melanomas sensitive to radiotherapy. Invest Ophthalmol Vis Sci. 2006;47:2300-4 pubmed
    ..Comprehensive gene expression profiles of radiation-sensitive and/or resistant cell lines may provide new insights into the mechanisms of resistance or sensitivity to radiation therapy. ..
  9. Goto T, Matsui Y, Fernandes R, Hanson D, Kubo T, Yukata K, et al. Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. J Bone Miner Res. 2006;21:661-73 pubmed
    ..The results establish that Sp1 proteins regulate COL11A2 transcription by binding to its proximal promoter and directly interacting with CBP, p300, and HDAC. ..
  10. Kaji H, Naito J, Sowa H, Sugimoto T, Chihara K. Smad3 differently affects osteoblast differentiation depending upon its differentiation stage. Horm Metab Res. 2006;38:740-5 pubmed
    ..Also, Smad3 enhanced the expression of mineralization-related genes at the maturation phase of MC3T3-E1 cells. ..
  11. Subedi K, Isobe N, Nishibori M, Yoshimura Y. Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response to lipopolysaccharide in laying hens (Gallus domesticus). Reproduction. 2007;133:127-33 pubmed
    ..Elevated levels of GAL-1, -7, and -12 expression in theca in response to LPS suggest that the theca cells expressing these GALs function to eliminate LPS-containing bacteria. ..
  12. Hirayama E, Kim J. Identification and characterization of a novel neural cell adhesion molecule (NCAM)-associated protein from quail myoblasts: relationship to myotube formation and induction of neurite-like protrusions. Differentiation. 2008;76:253-66 pubmed
    ..The results suggested that MYONAP influenced the functions of microtubules and was involved in the formation of myotubes via its interaction with NCAM. ..
  13. Hasegawa D, Fujii R, Yagishita N, Matsumoto N, Aratani S, Izumi T, et al. E3 ubiquitin ligase synoviolin is involved in liver fibrogenesis. PLoS ONE. 2010;5:e13590 pubmed publisher
    ..Our findings demonstrate the importance of the E3 ubiquitin ligase synoviolin in liver fibrosis. ..
  14. Okabe K, Hayashi M, Wakabayashi N, Yamawaki Y, Teranishi M, Fukushima N, et al. Different expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in mouse tumor cells. Pathobiology. 2010;77:309-14 pubmed publisher
    ..In this study, we measured expression levels and DNA methylation status of LPA receptor genes in mouse tumor cells, LL/2 lung carcinoma, B16F0 melanoma, FM3A mammary carcinoma and L1210 leukemia cells, compared with normal tissues...
  15. Tanaka Y, Kume S, Araki S, Isshiki K, Chin Kanasaki M, Sakaguchi M, et al. Fenofibrate, a PPAR? agonist, has renoprotective effects in mice by enhancing renal lipolysis. Kidney Int. 2011;79:871-82 pubmed publisher
    ..Whether amelioration of renal lipotoxicity by PPAR? agonists will turn out to be a useful strategy against CKD will require direct testing. ..
  16. Liu X, Sun Y, Zhang J, Li G, Wang Y. Identification of up-regulated genes in amphioxus neurula and the expression of AmphiFABP. Genes Genet Syst. 2011;86:37-46 pubmed
  17. Watada M, Shiota S, Matsunari O, Suzuki R, Murakami K, Fujioka T, et al. Association between Helicobacter pylori cagA-related genes and clinical outcomes in Colombia and Japan. BMC Gastroenterol. 2011;11:141 pubmed publisher
    ..In contrast, the prevalence of 4 candidate genes was independent of clinical outcomes in Japan. jhp0045 and jhp0046 might be novel markers for predicting gastric cancer in cagA-positive cases in Colombia, but not in Japan. ..
  18. Nakamichi N, Taguchi T, Hosotani H, Wakayama T, Shimizu T, Sugiura T, et al. Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: possible involvement in neuronal differentiation. Neurochem Int. 2012;61:1121-32 pubmed publisher
    ..This is the first evidence that OCTN1 plays a role in neuronal differentiation and proliferation, which are required for brain development. ..
  19. Nishiyama M, Kukimoto M, Beppu T, Horinouchi S. An operon encoding aspartokinase and purine phosphoribosyltransferase in Thermus flavus. Microbiology. 1995;141 ( Pt 5):1211-9 pubmed
    ..coli. Preliminary characterization of these enzymes produced in E. coli is described. ..
  20. Ahn J, Tanahashi N, Akiyama K, Hisamatsu H, Noda C, Tanaka K, et al. Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome. FEBS Lett. 1995;366:37-42 pubmed
    ..They also provide the basis for future structure/function studies of PA28 subunits and the determination of their relative physiological roles in the regulation of proteasome activity. ..
  21. Tamura S, Wang X, Maeda M, Futai M. Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes. Proc Natl Acad Sci U S A. 1993;90:10876-80 pubmed
    ..These results clearly suggest that GATA-GT1 and GATA-GT2 are involved in gene regulation specifically in the gastric epithelium and represent two additional members of the GATA-binding protein family. ..
  22. Matsumoto M, Nakagawa T, Inoue T, Nagata E, Tanaka K, Takano H, et al. Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature. 1996;379:168-71 pubmed
  23. Saitoh M, Nishitoh H, Amagasa T, Miyazono K, Takagi M, Ichijo H. Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta. J Biol Chem. 1996;271:2769-75 pubmed
    ..These observations indicate that serine 172 and threonine 176 of T beta R-I are dispensable for extracellular matrix protein production but essential to the growth inhibition by TGF-beta. ..
  24. Hirata T, Ushikubi F, Kakizuka A, Okuma M, Narumiya S. Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. J Clin Invest. 1996;97:949-56 pubmed
  25. Yabana N, Yamamoto M. Schizosaccharomyces pombe map1+ encodes a MADS-box-family protein required for cell-type-specific gene expression. Mol Cell Biol. 1996;16:3420-8 pubmed
    ..On the basis of these observations, we speculate that Map1 may be a transcriptional regulator of cell-type-specific genes similar to S. cerevisiae MCM1, whose activity is modulated by the oil and alpha2 mating-type gene products. ..
  26. Segi E, Sugimoto Y, Yamasaki A, Aze Y, Oida H, Nishimura T, et al. Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Biochem Biophys Res Commun. 1998;246:7-12 pubmed
    ..They also indicate that normal function of the EP4 receptor is essential in neonatal adaptation of the circulatory system. ..
  27. Gotoda Y, Wakamatsu N, Kawai H, Nishida Y, Matsumoto T. Missense and nonsense mutations in the lysosomal alpha-mannosidase gene (MANB) in severe and mild forms of alpha-mannosidosis. Am J Hum Genet. 1998;63:1015-24 pubmed
    ..These data demonstrate that widely heterogeneous missense or nonsense mutations of the MANB gene are the molecular basis underlying alpha-mannosidosis. ..
  28. Miura K, Miyoshi O, Yun K, Inazawa J, Miyamoto T, Hayashi H, et al. Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta. J Hum Genet. 1999;44:1-9 pubmed
    ..While the pentamer repeat might contribute to this effect, it is also possible that the differential allele usage might reflect the local chromosomal structure known as the imprinting domain. ..
  29. Tamaki N, Sakata S, Matsuda K. Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver. Methods Enzymol. 2000;324:376-89 pubmed
  30. Kimura K, Isashiki Y, Sonoda S, Kakiuchi Matsumoto T, Ohba N. Genetic association of manganese superoxide dismutase with exudative age-related macular degeneration. Am J Ophthalmol. 2000;130:769-73 pubmed
    ..Further association studies in other polymorphic genes for xenobiotic-metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of age-related macular degeneration. ..
  31. Saeki T, Takahashi N, Kanamoto R, Iwami K. Characterization of cloned mouse Na+/taurocholate cotransporting polypeptide by transient expression in COS-7 cells. Biosci Biotechnol Biochem. 2002;66:1116-8 pubmed
    ..This Km value is comparable to that for rat NTCP and higher than that for human NTCP. Substrate specificity was evaluated by measuring inhibitory effects of unlabeled bile acids on [3H]taurocholic acid transport. ..
  32. Shimogiri T, Miyagawa S, Lee E, Mannen H, Okamoto S, Maeda Y, et al. Linkage mapping of the mitochondrial aconitase (ACO2) gene to chicken chromosome 1. Anim Genet. 2002;33:312 pubmed
  33. Kubota K, Iseki S, Kuroda S, Oida S, Iimura T, Duarte W, et al. Synergistic effect of fibroblast growth factor-4 in ectopic bone formation induced by bone morphogenetic protein-2. Bone. 2002;31:465-71 pubmed
    ..Our results indicate that FGF-4 and FGFR signals play important roles during rhBMP-2-induced bone formation. We further suggest that the combination of rhBMP-2 and rhFGF-4 would be useful for bone augmentation. ..
  34. Zhang S, Mizutani A, Hisatsune C, Higo T, Bannai H, Nakayama T, et al. Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells. J Biol Chem. 2003;278:4048-56 pubmed
    ..1N blocks the localization of co-expressed IP(3)R1 at the basolateral membrane domain. These data indicate that 4.1N is required for IP(3)R1 translocation to the basolateral membrane domain in polarized MDCK cells. ..
  35. Imada Y, Takase A, Kikuma R, Iwamaru Y, Akachi S, Hayakawa Y. Serotyping of 800 strains of Erysipelothrix isolated from pigs affected with erysipelas and discrimination of attenuated live vaccine strain by genotyping. J Clin Microbiol. 2004;42:2121-6 pubmed
    ..Our results indicate that RAPD type 1-2 strains are live vaccine strains and that 37% of the cases of chronic swine erysipelas detected in the past 11 years in Japan have occurred as a side effect of live vaccine use...
  36. Tanaka H, Yamamoto M, Moriyama Y, Yamao M, Furukawa S, Sagisaka A, et al. A novel Rel protein and shortened isoform that differentially regulate antibacterial peptide genes in the silkworm Bombyx mori. Biochim Biophys Acta. 2005;1730:10-21 pubmed publisher
  37. Xu L, Harada H, Yokohama Tamaki T, Matsumoto S, Tanaka J, Taniguchi A. Reuptake of extracellular amelogenin by dental epithelial cells results in increased levels of amelogenin mRNA through enhanced mRNA stabilization. J Biol Chem. 2006;281:2257-62 pubmed
    ..Here we speculated that during differentiation, dental epithelial cells utilize a unique mechanism for increasing the production of amelogenin, the reuptake of secreted amelogenin. ..
  38. Watanabe S, Ueda Y, Akaboshi S, Hino Y, Sekita Y, Nakao M. HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells. Am J Pathol. 2009;174:854-68 pubmed publisher
    ..These data shed light on the importance of HMGA2 in reversibly maintaining EMT, suggesting that HMGA2 is a potential therapeutic target for the treatment of pancreatic cancer. ..
  39. Nishi M, Ryo A, Tsurutani N, Ohba K, Sawasaki T, Morishita R, et al. Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag. FEBS Lett. 2009;583:1243-50 pubmed publisher
    ..We thus propose that the microtubule network plays a role in SOCS1-mediated HIV-1 Gag transport and virus particle formation. ..
  40. Fujita K, Sagisaka A, Tomimoto K, Ishibashi J, Imanishi S, Yamakawa M, et al. DNA vector-based RNA interference in cell lines derived from Bombyx mori. Biosci Biotechnol Biochem. 2009;73:2026-31 pubmed
  41. Nagatomo F, Gu N, Fujino H, Takeda I, Tsuda K, Ishihara A. Skeletal muscle characteristics of rats with obesity, diabetes, hypertension, and hyperlipidemia. J Atheroscler Thromb. 2009;16:576-85 pubmed
    ..For example, the lower PGC-1alpha and MCAD mRNA expression levels in the soleus muscles of type 2 diabetic rats are associated with the presence of only low-oxidative type I fibers in the muscle. ..
  42. Ito H. Development of a cps-based multiplex PCR for typing of Actinobacillus pleuropneumoniae serotypes 1, 2 and 5. J Vet Med Sci. 2010;72:653-5 pubmed
    ..A cps-based multiplex PCR for typing of Actinobacillus pleuropneumoniae serotypes 1, 2 and 5 was developed. This method should be specific and practical in Japan where more than 88% of isolates are serotypes 1, 2 or 5. ..
  43. Takahashi R, Benitez E, Oyoo M, Khan N, Komatsu S. Nonsense mutation of an MYB transcription factor is associated with purple-blue flower color in soybean. J Hered. 2011;102:458-63 pubmed publisher
    ..The polymorphic CAPS marker co-segregated with alleles at the W2 locus in the F(2) population. These results suggest that GmMYB-G20-1 might correspond to the W2 gene. ..
  44. Shimomura Y, Morimoto S, Takada Hoshino Y, Uchida Y, Akiyama H, Hayatsu M. Comparison among amoA primers suited for quantification and diversity analyses of ammonia-oxidizing bacteria in soil. Microbes Environ. 2012;27:94-8 pubmed
    ..We found that PCR-DGGE analysis with the amoA-2IR primer gave the best results in this studied soil. These results indicate that amoA-2IR is a suitable primer for community analysis of AOB in the environment...
  45. Kuge S, Jones N, Nomoto A. Regulation of yAP-1 nuclear localization in response to oxidative stress. EMBO J. 1997;16:1710-20 pubmed
    ..We suggest therefore, that these cysteine residues are important in sensing the redox state of the cell and hence regulating yAP-1 activity...
  46. Maeno Hikichi Y, Tanaka K, Shibata T, Watanabe M, Inoue Y, Mukainaka Y, et al. Structure and functional expression of the cloned mouse neuronal high-affinity glutamate transporter. Brain Res Mol Brain Res. 1997;48:176-80 pubmed
    ..In situ hybridization in mouse brain sections showed that the mRNA is expressed densely and selectively in cell bodies of Purkinje cells...
  47. Suzuki F, Miyamoto S, Takita M, Oshita M, Watanabe Y, Kakizuka A, et al. Cloning, functional expression and tissue distribution of rabbit alpha 1d-adrenoceptor. Biochim Biophys Acta. 1997;1323:6-11 pubmed
    ..Competitive RT/PCR assays revealed wide tissue distribution of the alpha 1d-adrenoceptor mRNA in rabbit, especially abundant in vas deferens, aorta, prostate and cerebral cortex. ..
  48. Yamamoto K, Kobayashi H, Arai A, Miura O, Hirosawa S, Miyasaka N. cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3. Cytogenet Cell Genet. 1997;77:207-10 pubmed
    ..However, human STAT1 is expressed ubiquitously, whereas human STAT4 is expressed in several tissues including spleen, heart, brain, peripheral blood cells, and testis. ..
  49. Oka M, Nakai M, Endo T, Lim C, Kimata Y, Kohno K. Loss of Hsp70-Hsp40 chaperone activity causes abnormal nuclear distribution and aberrant microtubule formation in M-phase of Saccharomyces cerevisiae. J Biol Chem. 1998;273:29727-37 pubmed
    ..Finally, the observation that SSA1 and YDJ1 interact genetically with a gamma-tubulin, TUB4, supports the idea that they play a role in the regulation of microtubule formation. ..
  50. Takahashi H, Inumaru S, Takahashi M, Watanabe S, Iga K, Yokomizo Y, et al. Biological activity of recombinant bovine interferon tau using an Autographa californica nuclear polyhedrosis virus expression system. J Reprod Dev. 2003;49:433-40 pubmed
    ..These results showed that biologically active rbIFNtau was produced in the baculovirus expression system, and that rbIFNtau had the ability to suppress the synthesis of PGF(2alpha) from bovine endometrial epithelial cells. ..
  51. Osonoi T, Saito M, Mochizuki K, Fukaya N, Muramatsu T, Inoue S, et al. The ?-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus. Metabolism. 2010;59:1816-22 pubmed publisher
  52. Okabayashi K, Shoji H, Nakamura T, Hashimoto O, Asashima M, Sugino H. cDNA cloning and expression of the Xenopus laevis vitellogenin receptor. Biochem Biophys Res Commun. 1996;224:406-13 pubmed
    ..6 kb in Xenopus ovary, weak but significant expression was observed in other tissues by RT-PCR analysis. The fact that major expression of the gene occurs in the ovary suggests that it has an important function in this organ. ..
  53. Ichimiya T, Manya H, Ohmae Y, Yoshida H, Takahashi K, Ueda R, et al. The twisted abdomen phenotype of Drosophila POMT1 and POMT2 mutants coincides with their heterophilic protein O-mannosyltransferase activity. J Biol Chem. 2004;279:42638-47 pubmed
    ..These results demonstrate that the two dPOMTs function as a protein O-mannosyltransferase in association with each other, in vitro and in vivo, to generate and maintain normal muscle development. ..
  54. Onishi Y, Hanai S, Ohno T, Hara Y, Ishida N. Rhythmic SAF-A binding underlies circadian transcription of the Bmal1 gene. Mol Cell Biol. 2008;28:3477-88 pubmed publisher
    ..These results suggest that the unique chromatin structure containing SAF-A is required for the circadian transcriptional regulation of the Bmal1 gene in cells. ..
  55. Yoshimura T, Ashiuchi M, Esaki N, Kobatake C, Choi S, Soda K. Expression of glr (murI, dga) gene encoding glutamate racemase in Escherichia coli. J Biol Chem. 1993;268:24242-6 pubmed
    ..We partially purified the enzyme to characterize it. The enzyme consists of two identical subunits with a molecular weight of about 31,000 in contrast to the P. pentosaceus enzyme, a monomer protein. ..
  56. Sasaki N, Hayashizaki Y, Muramatsu M, Matsuda Y, Ando Y, Kuramoto T, et al. The gene responsible for LEC hepatitis, located on rat chromosome 16, is the homolog to the human Wilson disease gene. Biochem Biophys Res Commun. 1994;202:512-8 pubmed
    ..This rat WD gene was mapped to 16q12.23-12.3 by fluorescence in situ hybridization and mouse x rat somatic cell hybrid analysis. ..
  57. Tomoda T, Kudoh T, Noma T, Nakazawa A, Muramatsu M, Arai K. Molecular cloning of a mouse counterpart for human TGF-beta type I receptor. Biochem Biophys Res Commun. 1994;198:1054-62 pubmed
    ..The extracellular domain is 90% homologous with a deletion and an insertion of four amino acid residues. ESK2 also binds to TGF-beta in the presence of TGF beta RII, indicating that ESK2 is the mouse counterpart for human TGF beta RI. ..
  58. Sugimoto K, Sakamoto Y, Takahashi O, Matsumoto K. HYS2, an essential gene required for DNA replication in Saccharomyces cerevisiae. Nucleic Acids Res. 1995;23:3493-500 pubmed
    ..HYS2 encodes a 55 kDa protein that is essential for viability at all temperatures. Taken together, these data suggest that Hys2 plays a role in DNA replication. ..
  59. Cho M, Uemura H, Kim S, Kawada Y, Yoshida K, Hirao Y, et al. Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma. Br J Cancer. 2001;85:563-7 pubmed
    ..These findings suggest that hypomethylation of the CpG at -74 bp in the MN/CA9 promoter region might play an important role in this gene activation of human RCC. ..
  60. Sugino H. ICAM-3, a ligand for DC-SIGN, was duplicated from ICAM-1 in mammalian evolution, but was lost in the rodent genome. FEBS Lett. 2005;579:2901-6 pubmed
    ..Thus, ICAM-3 arose from ICAM-1 in the mammalian evolution, but was lost in the rodent's genome. Our study suggests the different immune response in the rodents in comparison with other mammals. ..
  61. Omata K, Suzuki R, Masaki T, Miyamura T, Satoh T, Suzuki T. Identification and characterization of the human inhibitor of caspase-activated DNase gene promoter. Apoptosis. 2008;13:929-37 pubmed publisher
    ..Structural analysis of the human ICAD promoter and identification of factors which regulate its activity might further our understanding of the biological role of ICAD with respect to regulation of apoptosis and cancer development. ..
  62. Akiyama Y, Shirai Y, Ito K. Involvement of FtsH in protein assembly into and through the membrane. II. Dominant mutations affecting FtsH functions. J Biol Chem. 1994;269:5225-9 pubmed
    ..It was suggested that the amino-terminal membrane region of FtsH interacts with other component(s), and that the two putative ATP binding sites are of vital importance for the FtsH functions. ..
  63. Mizobuchi M, Murao K, Takeda R, Kakimoto Y. Tissue-specific expression of isoaspartyl protein carboxyl methyltransferase gene in rat brain and testis. J Neurochem. 1994;62:322-8 pubmed
    ..Both structural and developmental studies show that the expression of the PIMT gene in brain and testis is regulated in a tissue-specific manner. ..
  64. Kimura T, Kadokawa Y, Harada H, Matsumoto M, Sato M, Kashiwazaki Y, et al. Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies. Genes Cells. 1996;1:115-24 pubmed
    ..p48 and IRF-1 do not perform redundant functions in the cell, but rather complement one another in both type I and II IFN responses. ..
  65. Yoshida S, Anraku Y. Characterization of staurosporine-sensitive mutants of Saccharomyces cerevisiae: vacuolar functions affect staurosporine sensitivity. Mol Gen Genet. 2000;263:877-88 pubmed
  66. Fan Y, Kohno M, Nakano D, Ohsaki H, Kobori H, Suwarni D, et al. Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte. J Hypertens. 2010;28:1034-43 pubmed
    ..In the present study, we examined the effects of cilnidipine and amlodipine on the renal injury in spontaneously hypertensive rat/ND mcr-cp (SHR/ND) and their underlying mechanism...
  67. Akiyama Y, Yoshihisa T, Ito K. FtsH, a membrane-bound ATPase, forms a complex in the cytoplasmic membrane of Escherichia coli. J Biol Chem. 1995;270:23485-90 pubmed
    ..We suggest that the N-terminal transmembrane region of FtsH mediates directly the interaction between the FtsH subunits. ..
  68. Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, et al. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. J Biol Chem. 1994;269:1231-6 pubmed
    ..mGluR7 together with mGluR4 thus corresponds to the putative L-2-amino-4-phosphonobutyrate receptor which plays an important role in modulation of glutamate transmission in the central nervous system. ..
  69. Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K. Substitution at codon 269 (glutamine --> proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun. 1996;224:597-604 pubmed
    ..These facts suggest that the substitution at codon 269 of the OB-R cDNA represents the crucial mutation which results in the obese phenotype of Zucker (fa/fa) rat. ..
  70. Ito K, Okamoto I, Araki N, Kawano Y, Nakao M, Fujiyama S, et al. Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts. Oncogene. 1999;18:7080-90 pubmed
  71. Kato H, Tsuchiya N, Tokunaga K. Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3. Genes Immun. 2000;1:330-7 pubmed
    ..However, CXCR variations identified in this study will provide valuable information for the future studies in medical sciences as well as in human genetics. ..
  72. Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H. Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo. Oncogene. 1994;9:2991-8 pubmed
    ..This is the first detection of cytoplasmic signal transducers that bind to the ltk protein in vivo. ..
  73. Mitsui S, Yamada T, Okui A, Kominami K, Uemura H, Yamaguchi N. A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate. Biochem Biophys Res Commun. 2000;272:205-11 pubmed
    ..These results indicated that TLSP/hippostasin is involved in the functions of the human central nervous system and prostate and that it is a multifunctional protease present in various organs. ..
  74. Amano T, Tanabe K, Eto T, Narumiya S, Mizuno K. LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. Biochem J. 2001;354:149-59 pubmed
    ..These results suggest that LIMK2 functions downstream of the Rho-ROCK signalling pathway and plays a role in reorganization of actin filaments and membrane structures, by phosphorylating cofilin/ADF proteins. ..
  75. Imai K, Harada S, Kawanishi Y, Tachikawa H, Okubo T, Asada T. Association analysis of an (AC)n repeat polymorphism in the GABA(B) receptor gene and schizophrenia. Am J Med Genet. 2002;114:605-8 pubmed
    ..0015). These differences, however, were not significant after Bonferroni correction. These data did not support our hypothesis that polymorphisms of the GABA(B) receptor gene may confer vulnerability for schizophrenia. ..
  76. Kanai M, Konda Y, Nakajima T, Izumi Y, Kanda N, Nanakin A, et al. Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway. Oncogene. 2003;22:548-54 pubmed
  77. Hirano S, Kitajima H, Hayakawa T, Cui X, Kanno S, Kobayashi Y, et al. PCR-based subtraction analyses for upregulated gene transcription in cadmium-exposed rat lung type 2 epithelial cells. Biochem Biophys Res Commun. 2003;308:133-8 pubmed
    ..AB086193) mRNAs were weakly inducible. The expression of cdig1 increased linearly with time up to 9h, while that of HO-1 reached the maximum value at 4h in response to 10 microM Cd. ..
  78. Bosak N, Faraut T, Mikawa S, Uenishi H, Kiuchi S, Hiraiwa H, et al. Construction of a high-resolution comparative gene map between swine chromosome region 6q11-->q21 and human chromosome 19 q-arm by RH mapping of 51 genes. Cytogenet Genome Res. 2003;102:109-15 pubmed
    ..For the ERF and PSMD8 genes assigned to SSCs other than SSC6, additional mapping using somatic cell hybrid (SCH) panels was performed to confirm the results of RH-mapping. ..
  79. Shirahane K, Yamaguchi K, Koga K, Watanabe M, Kuroki S, Tanaka M. Hepatic ischemia/reperfusion injury is prevented by a novel matrix metalloproteinase inhibitor, ONO-4817. Surgery. 2006;139:653-64 pubmed
    ..Hepatic ischemia/reperfusion injury was improved by a novel MMP inhibitor, ONO-4817, not only by inhibition of gelatinolytic activity but also by a decrease in release of inflammatory cytokines. ..
  80. Fujii M, Ogata T, Takahashi E, Yamada K, Nakabayashi K, Oishi M, et al. Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells. FEBS Lett. 1995;375:263-7 pubmed
    ..Also in various immortalized cell lines tested, the gene was not expressed. In normal diploid fibroblasts, the gene was constitutively expressed during cell-cycle and population doubling levels (PDLs). ..
  81. Hirata M, Kakizuka A, Aizawa M, Ushikubi F, Narumiya S. Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. Proc Natl Acad Sci U S A. 1994;91:11192-6 pubmed
    ..Northern blotting analysis with mouse poly(A)+ RNA identified a major mRNA species of 3.5 kb that was most abundantly expressed in the ileum, followed by lung, stomach, and uterus. ..
  82. Hiroshima K, Toyozaki T, Iyoda A, Ohwada H, Kado S, Shirasawa H, et al. Ultrastructural study of intranuclear inclusion bodies of pulmonary adenocarcinoma. Ultrastruct Pathol. 1999;23:383-9 pubmed
    ..HPV DNA was detected using PCR and type-specific probes in a case with type A inclusion bodies. This study suggests that intranuclear inclusion bodies in pulmonary adenocarcinoma are formed by several different mechanisms. ..
  83. Ikezumi Y, Kawachi H, Toyabe S, Uchiyama M, Shimizu F. An anti-CD5 monoclonal antibody ameliorates proteinuria and glomerular lesions in rat mesangioproliferative glomerulonephritis. Kidney Int. 2000;58:100-14 pubmed
    ..4 +/- 0.2 vs. 2.2 +/- 0. 4, cf2eth P < 0.01) on day 14 after induction of GN. mRNA expression for IL-2 was significantly reduced by OX-19 treatment. T lymphocytes participate in the development of mesangial proliferative GN. ..
  84. Shibuya A, Sakamoto N, Shimizu Y, Shibuya K, Osawa M, Hiroyama T, et al. Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes. Nat Immunol. 2000;1:441-6 pubmed
    ..Fc alpha/microR also mediated primary B lymphocyte endocytosis of IgM-coated Staphylococcus aureus. Thus, Fc alpha/microR is involved in the primary stages of the immune response to microbes. ..
  85. Tsuruha J, Masuko Hongo K, Kato T, Sakata M, Nakamura H, Nishioka K. Implication of cartilage intermediate layer protein in cartilage destruction in subsets of patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum. 2001;44:838-45 pubmed
    ..The results suggest that suppression of immune responses to various components of the cartilage, such as CILP, might be therapeutically beneficial in these chronic arthropathies. ..
  86. Kojima K, Nakashima F, Boku A, Muroishi Y, Nakanishi I, Oda Y. Clinicopathological study of involvement of granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor in non-lymphohematopoietic malignant tumors accompanied by leukocytosis. Histol Histopathol. 2002;17:1005-16 pubmed publisher
    ..Other stimulating factors may be involved in the development of leukocytosis in such cases. ..
  87. Kimura K, Miki T, Shibasaki T, Zhang Y, Ogawa M, Saisho H, et al. Functional analysis of transcriptional repressor Otx3/Dmbx1. FEBS Lett. 2005;579:2926-32 pubmed
    ..These data suggest that Otx3/Dmbx1 represses Otx2-mediated transcription in the developing brain. We also identified the consensus binding sequence [TAATCCGATTA and TAATCC(N2-4)TAATCC] of Otx3/Dmbx1. ..
  88. Takada H, Hattori D, Kitayama A, Ueno N, Taira M. Identification of target genes for the Xenopus Hes-related protein XHR1, a prepattern factor specifying the midbrain-hindbrain boundary. Dev Biol. 2005;283:253-67 pubmed
    ..Taken together, we propose a model in which XHR1 defines the pre-MHB region as a prepattern gene by repressing those possible direct target genes. ..
  89. Kikawa Y, Inuzuka M, Jin B, Kaji S, Yamamoto Y, Shigematsu Y, et al. Identification of a genetic mutation in a family with fructose-1,6- bisphosphatase deficiency. Biochem Biophys Res Commun. 1995;210:797-804 pubmed
    ..Thus, this mutation is concluded to be responsible for fructose-1,6-bisphosphatase deficiency in this patient. ..
  90. Takahashi T, Shirasawa T. Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases. FEBS Lett. 1994;342:124-8 pubmed
    ..Northern analysis indicated that the 4.0 kb mRNA was transcribed in a variety of tissues including spleen, lung, kidney and intestine. ..
  91. Kondo M, Sato S, Sutou S. Cloning and sequence analysis of cDNA encoding the bovine testis-derived male-enhanced antigen (Mea). Biochim Biophys Acta. 1993;1216:483-6 pubmed
    ..9%, 165/172) and mouse (92.5%, 161/174) Mea gene products. It is located on an autosome, and is expressed highly in the testes. ..
  92. Daikoku T, Shibata S, Goshima F, Oshima S, Tsurumi T, Yamada H, et al. Purification and characterization of the protein kinase encoded by the UL13 gene of herpes simplex virus type 2. Virology. 1997;235:82-93 pubmed
    ..We have also determined the complete nucleotide sequence of the HSV-2 UL13 gene. The overall amino acid homology between the HSV-2 and HSV-1 UL13 PKs was 85.9% and the homology was highly conserved in the C-terminal region. ..