Experts and Doctors on dna polymerase beta in France


Locale: France
Topic: dna polymerase beta

Top Publications

  1. Menoni H, Gasparutto D, Hamiche A, Cadet J, Dimitrov S, Bouvet P, et al. ATP-dependent chromatin remodeling is required for base excision repair in conventional but not in variant H2A.Bbd nucleosomes. Mol Cell Biol. 2007;27:5949-56 pubmed
    ..A very weak effect of SWI/SNF on the 8-oxoG BER removal in H2A.Bbd histone variant nucleosomes was observed. The possible implications of our data for the understanding of in vivo mechanisms of BER are discussed. ..
  2. Reynaud C, Frey S, Aoufouchi S, Faili A, Bertocci B, Dahan A, et al. Transcription, beta-like DNA polymerases and hypermutation. Philos Trans R Soc Lond B Biol Sci. 2001;356:91-7 pubmed
    ..Peculiar features of the expression of this gene, including an unusual splicing variability and a splicing inhibition in response to DNA-damaging agents, are discussed. ..
  3. Villani G, Hubscher U, Gironis N, Parkkinen S, Pospiech H, Shevelev I, et al. In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta. J Biol Chem. 2011;286:32094-104 pubmed publisher
    ..Collectively, our in vitro results support the existence of a mechanism of gap-directed TLS at an AP site involving a switch between the replicative pol ? and the repair pols ? and ?. ..
  4. Aoufouchi S, Flatter E, Dahan A, Faili A, Bertocci B, Storck S, et al. Two novel human and mouse DNA polymerases of the polX family. Nucleic Acids Res. 2000;28:3684-93 pubmed
    ..This suggests that their biological function may differ from DNA translesion synthesis, for which several DNA polymerase activities have been recently described. Possible functions are discussed. ..
  5. Pélissier T, Clavel M, Chaparro C, Pouch Pélissier M, Vaucheret H, Deragon J. Double-stranded RNA binding proteins DRB2 and DRB4 have an antagonistic impact on polymerase IV-dependent siRNA levels in Arabidopsis. RNA. 2011;17:1502-10 pubmed publisher
    ..Moreover, transgenic plants overexpressing DRB2 mimicked drb4 mutants at the morphological and molecular levels, confirming the antagonistic roles of DRB2 and DRB4. ..
  6. Goula A, Berquist B, Wilson D, Wheeler V, Trottier Y, Merienne K. Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice. PLoS Genet. 2009;5:e1000749 pubmed publisher
    ..We propose that the stoichiometry of BER enzymes is one critical factor underlying the tissue selectivity of somatic CAG expansion. ..
  7. Wagner J, Etienne H, Fuchs R, Cordonnier A, Burnouf D. Distinct beta-clamp interactions govern the activities of the Y family PolIV DNA polymerase. Mol Microbiol. 2009;74:1143-51 pubmed publisher
    ..This discloses two independent modes of action for PolIV and, in turn, uncovers a novel way by which the cell may regulate the potentially deleterious effect of such low fidelity polymerases during replication. ..
  8. Emond S, Mondon P, Pizzut Serin S, Douchy L, Crozet F, Bouayadi K, et al. A novel random mutagenesis approach using human mutagenic DNA polymerases to generate enzyme variant libraries. Protein Eng Des Sel. 2008;21:267-74 pubmed publisher
    ..By taking advantage of the mutation bias of naturally highly error-prone DNA polymerases, MutaGen thus appears as a very useful tool for gene and protein randomisation. ..
  9. Bjedov I, Dasgupta C, Slade D, Le Blastier S, Selva M, Matic I. Involvement of Escherichia coli DNA polymerase IV in tolerance of cytotoxic alkylating DNA lesions in vivo. Genetics. 2007;176:1431-40 pubmed
    ..This activity is of major biological relevance because alkylating agents are continuously produced endogenously in all living cells and are also present in the environment. ..

More Information


  1. Rouillon C, Henneke G, Flament D, Querellou J, Raffin J. DNA polymerase switching on homotrimeric PCNA at the replication fork of the euryarchaea Pyrococcus abyssi. J Mol Biol. 2007;369:343-55 pubmed
    ..Then, Pol D is displaced by Pol B to perform processive DNA synthesis, at least on the leading strand...
  2. Bertocci B, De Smet A, Weill J, Reynaud C. Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo. Immunity. 2006;25:31-41 pubmed
  3. Delmas S, Matic I. Interplay between replication and recombination in Escherichia coli: impact of the alternative DNA polymerases. Proc Natl Acad Sci U S A. 2006;103:4564-9 pubmed
  4. Blanca G, Villani G, Shevelev I, Ramadan K, Spadari S, Hubscher U, et al. Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation. Biochemistry. 2004;43:11605-15 pubmed
  5. Marsin S, Vidal A, Sossou M, Menissier de Murcia J, Le Page F, Boiteux S, et al. Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1. J Biol Chem. 2003;278:44068-74 pubmed
  6. Becherel O, Fuchs R, Wagner J. Pivotal role of the beta-clamp in translesion DNA synthesis and mutagenesis in E. coli cells. DNA Repair (Amst). 2002;1:703-8 pubmed
    ..Thus, in addition to its crucial role as the processivity factor of the PolIII replicase, the beta-clamp plays a pivotal role during the TLS process. ..
  7. Servant L, Cazaux C, Bieth A, Iwai S, Hanaoka F, Hoffmann J. A role for DNA polymerase beta in mutagenic UV lesion bypass. J Biol Chem. 2002;277:50046-53 pubmed
    ..These data support a biological role of pol beta in UV lesion bypass and suggest that deregulated pol beta may enhance UV-induced genetic instability. ..
  8. Schreiber V, Ame J, Dolle P, Schultz I, Rinaldi B, Fraulob V, et al. Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J Biol Chem. 2002;277:23028-36 pubmed