Experts and Doctors on dna methylation in Sweden


Locale: Sweden
Topic: dna methylation

Top Publications

  1. Edin S, Wikberg M, Dahlin A, RutegÃ¥rd J, Öberg Ã, Oldenborg P, et al. The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer. PLoS ONE. 2012;7:e47045 pubmed publisher
  2. Radmark O, Werz O, Steinhilber D, Samuelsson B. 5-Lipoxygenase: regulation of expression and enzyme activity. Trends Biochem Sci. 2007;32:332-41 pubmed
    ..With regard to the control of enzyme activity, many of these findings focus on the N-terminal domain of 5-LO. ..
  3. Svensson Månsson S, Reis Filho J, Landberg G. Transcriptional upregulation and unmethylation of the promoter region of p16 in invasive basal cell carcinoma cells and partial co-localization with the gamma 2 chain of laminin-332. J Pathol. 2007;212:102-11 pubmed
  4. Farkas S, Befekadu R, Hahn Strömberg V, Nilsson T. DNA methylation and expression of the folate transporter genes in colorectal cancer. Tumour Biol. 2015;36:5581-90 pubmed publisher
    ..The results encourage further investigation into the possible prognostic implications of folate transporter expression and DNA methylation. ..
  5. Caren H, Ejeskär K, Fransson S, Hesson L, Latif F, Sjöberg R, et al. A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylation. Mol Cancer. 2005;4:10 pubmed
    ..The genes UBE4B, KIF1B, PGD, APITD1, DFFA and PEX14 are down-regulated in high stage NB tumours, a feature that can not be explained by CpG island methylation. ..
  6. Ginjala V, Holmgren C, Ullerås E, Kanduri C, Pant V, Lobanenkov V, et al. Multiple cis elements within the Igf2/H19 insulator domain organize a distance-dependent silencer. A cautionary note. J Biol Chem. 2002;277:5707-10 pubmed
    ..We issue a cautionary note, therefore, that the interpretation of insulator/silencer data could be erroneous should the distance issue not be taken into consideration. ..
  7. Lee J, Geli J, Larsson C, Wallin G, Karimi M, Zedenius J, et al. Gene-specific promoter hypermethylation without global hypomethylation in follicular thyroid cancer. Int J Oncol. 2008;33:861-9 pubmed
    ..0002). In summary, the epigenetic inactivation of RASSF1A is a frequent event in FTC, but is not coupled to changes in global methylation. ..
  8. Heyman Lindén L, Seki Y, Storm P, Jones H, Charron M, Berger K, et al. Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet. J Nutr Biochem. 2016;27:79-95 pubmed publisher
    ..NF-κB, STAT3 and mTOR are potential targets of the health-promoting effects of berries. ..
  9. Gillberg L, Perfilyev A, Brøns C, Thomasen M, Grunnet L, Volkov P, et al. Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding. Diabetologia. 2016;59:799-812 pubmed publisher
    ..Short-term overfeeding influences gene transcription and, to some extent, DNA methylation in adipose tissue; there was no major difference in this response between LBW and control participants. ..

More Information


  1. Willems E, Guerrero Bosagna C, Decuypere E, Janssens S, Buyse J, Buys N, et al. Differential Expression of Genes and DNA Methylation associated with Prenatal Protein Undernutrition by Albumen Removal in an avian model. Sci Rep. 2016;6:20837 pubmed publisher
    ..In conclusion, these results demonstrated that prenatal protein undernutrition by albumen removal leads to long-term alterations of the hepatic transcriptome in the chicken. ..
  2. Putnik M, Zhao C, Gustafsson J, Dahlman Wright K. Global identification of genes regulated by estrogen signaling and demethylation in MCF-7 breast cancer cells. Biochem Biophys Res Commun. 2012;426:26-32 pubmed publisher
    ..However, our data does not support a direct molecular interplay of mediators of estrogen and epigenetic signaling at promoters of regulated genes. ..
  3. Nätt D, Rubin C, Wright D, Johnsson M, Beltéky J, Andersson L, et al. Heritable genome-wide variation of gene expression and promoter methylation between wild and domesticated chickens. BMC Genomics. 2012;13:59 pubmed publisher
  4. Kokosar M, Benrick A, Perfilyev A, Fornes R, Nilsson E, Maliqueo M, et al. Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome. Sci Rep. 2016;6:22883 pubmed publisher
    ..Together, these novel findings show that women with PCOS have multiple transcriptional and epigenetic changes in adipose tissue that are relevant for development of the disease. ..
  5. Welin S, Sorbye H, Sebjornsen S, Knappskog S, Busch C, Oberg K. Clinical effect of temozolomide-based chemotherapy in poorly differentiated endocrine carcinoma after progression on first-line chemotherapy. Cancer. 2011;117:4617-22 pubmed publisher
    ..These results indicated that temozolomide may be used as second-line treatment in PDEC. ..
  6. Ekström E, Sherwood V, Andersson T. Methylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasion. PLoS ONE. 2011;6:e18674 pubmed publisher
    ..We conclude that SFRP3 functions as a melanoma migration and invasion suppressor by interfering with Wnt5a signaling. ..
  7. Barres R, Yan J, Egan B, Treebak J, Rasmussen M, Fritz T, et al. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012;15:405-11 pubmed publisher
  8. Sulaiman L, Juhlin C, Nilsson I, Fotouhi O, Larsson C, Hashemi J. Global and gene-specific promoter methylation analysis in primary hyperparathyroidism. Epigenetics. 2013;8:646-55 pubmed publisher
    ..289, p < 0.05) and ?-catenin (r = 0.315, p < 0.01). Our findings suggest a role for aberrant DNA promoter methylation of APC 1A, ?-catenin and RASSF1A in a subset of parathyroid tumors. ..
  9. Enroth S, Rada Iglesisas A, Andersson R, Wallerman O, Wanders A, Pahlman L, et al. Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa. BMC Cancer. 2011;11:450 pubmed publisher
    ..This strategy gives further insights into the epigenetic contribution to the oncogenic process and may identify new biomarkers. ..
  10. Shi W, Krella A, Orth A, Yu Y, Fundele R. Widespread disruption of genomic imprinting in adult interspecies mouse (Mus) hybrids. Genesis. 2005;43:100-8 pubmed
    ..We propose that abnormal reprogramming after fertilization and during preimplantation development is in part responsible for hybrid dysgenesis, for which a strong epigenetic basis has been demonstrated. ..
  11. Pant V, Kurukuti S, Pugacheva E, Shamsuddin S, Mariano P, Renkawitz R, et al. Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance. Mol Cell Biol. 2004;24:3497-504 pubmed
    ..Considering many other CTCF targets, we propose that site-specific interactions between various DNA-bound CTCF molecules may provide general focal points in the organization of looped chromatin domains involved in gene regulation. ..
  12. Geli J, Kiss N, Kogner P, Larsson C. Suppression of RIZ in biologically unfavourable neuroblastomas. Int J Oncol. 2010;37:1323-30 pubmed
    ..005). Suppression of RIZ1 is likely to contribute to the pathogenesis of biologically unfavourable neuroblastomas. In contrast to multiple other neoplasias, RIZ1 promoter methylation is not a common event in neuroblastoma. ..
  13. Arzenani M, Zade A, Ming Y, Vijverberg S, Zhang Z, Khan Z, et al. Genomic DNA hypomethylation by histone deacetylase inhibition implicates DNMT1 nuclear dynamics. Mol Cell Biol. 2011;31:4119-28 pubmed publisher
    ..Our study sheds light on the molecular mechanisms underlying the synergistic action of HDACi and DNMTi and may also help to define improved policies for cancer treatment. ..
  14. Davidsson J, Andersson A, Paulsson K, Heidenblad M, Isaksson M, Borg A, et al. Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpress. Hum Mol Genet. 2007;16:2215-25 pubmed
    ..However, involvement of these genes in dup(1q)-positive ALLs and BLs has previously not been reported. ..
  15. Geli J, Kiss N, Lanner F, Foukakis T, Natalishvili N, Larsson O, et al. The Ras effectors NORE1A and RASSF1A are frequently inactivated in pheochromocytoma and abdominal paraganglioma. Endocr Relat Cancer. 2007;14:125-34 pubmed
    ..Our study provides evidence that NORE1A and RASSF1A are frequently suppressed in pheochromocytoma and abdominal paraganglioma. Silencing of NORE1A contributes to the transformed phenotype in these tumours...
  16. Nestor C, Barrenas F, Wang H, Lentini A, Zhang H, Bruhn S, et al. DNA methylation changes separate allergic patients from healthy controls and may reflect altered CD4+ T-cell population structure. PLoS Genet. 2014;10:e1004059 pubmed publisher
    ..Our data highlight the potential of epigenomics in the stratification of immune disease and represents the first successful molecular classification of SAR using CD4(+) T cells. ..
  17. Thakur N, Tiwari V, Thomassin H, Pandey R, Kanduri M, Göndör A, et al. An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region. Mol Cell Biol. 2004;24:7855-62 pubmed
    ..Double-stranded RNA (dsRNA)-mediated RNA interference is unlikely to be involved, as the ICR is active irrespective of the simultaneous production of dsRNA from the genes it silences. ..
  18. Van Laere A, Nguyen M, Braunschweig M, Nezer C, Collette C, Moreau L, et al. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature. 2003;425:832-6 pubmed
    ..The result supports the long-held view that regulatory mutations are important for controlling phenotypic variation. ..
  19. Kanduri M, Marincevic M, Halldorsdottir A, Mansouri L, Junevik K, Ntoufa S, et al. Distinct transcriptional control in major immunogenetic subsets of chronic lymphocytic leukemia exhibiting subset-biased global DNA methylation profiles. Epigenetics. 2012;7:1435-42 pubmed publisher
  20. Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund Sayeed S, et al. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science. 2017;356: pubmed publisher
    ..This study provides a systematic examination of the effect of an epigenetic DNA modification on human TF binding specificity and reveals that many developmentally important proteins display preference for mCpG-containing sequences. ..
  21. Reinius B, Kanduri C. Elevated expression of H19 and Igf2 in the female mouse eye. PLoS ONE. 2013;8:e56611 pubmed publisher
    ..The female-biased expression of H19 and Igf2 specifically in the eye may contribute to our understanding of sex differences in normal as well as abnormal eye physiology and processes. ..
  22. Cai D, Yuan M, Jia Y, Liu H, Hu Y, Zhao R. Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway. J Nutr Biochem. 2015;26:1622-31 pubmed publisher
    ..These neonatal changes in cell cycle and proliferation regulation may lead to lower liver weight and hepatic DNA content at weaning. ..
  23. Svedlund J, Aurén M, Sundstrom M, Dralle H, Akerstrom G, Björklund P, et al. Aberrant WNT/?-catenin signaling in parathyroid carcinoma. Mol Cancer. 2010;9:294 pubmed publisher
    ..The molecular etiology of PC is poorly understood...
  24. Kanduri C, Fitzpatrick G, Mukhopadhyay R, Kanduri M, Lobanenkov V, Higgins M, et al. A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator. J Biol Chem. 2002;277:18106-10 pubmed
    ..Moreover, we document that CpG methylation regulates this insulator function suggesting that a methylation-sensitive chromatin insulator is a common theme in the phenomenon of genomic imprinting. ..
  25. Ma S, Egyhazi S, Martenhed G, Ringborg U, Hansson J. Analysis of O(6)-methylguanine-DNA methyltransferase in melanoma tumours in patients treated with dacarbazine-based chemotherapy. Melanoma Res. 2002;12:335-42 pubmed
    ..077). ..
  26. Pant V, Mariano P, Kanduri C, Mattsson A, Lobanenkov V, Heuchel R, et al. The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains. Genes Dev. 2003;17:586-90 pubmed
    ..Because CTCF interacts with other imprinting control regions, it emerges as a central factor responsible for interpreting and propagating gamete-derived epigenetic marks and for organizing epigenetically controlled expression domains. ..
  27. Kiss C, Nishikawa J, Takada K, Trivedi P, Klein G, Szekely L. T cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus-carrying Burkitt lymphoma lines. Proc Natl Acad Sci U S A. 2003;100:4813-8 pubmed
    ..In the originally EBV-positive BLs, the ability of the virus to switch on TCL-1 expression would obviate this need. ..
  28. Geli J, Nord B, Frisk T, Edström Elder E, Ekström T, Carling T, et al. Deletions and altered expression of the RIZ1 tumour suppressor gene in 1p36 in pheochromocytomas and abdominal paragangliomas. Int J Oncol. 2005;26:1385-91 pubmed
    ..The recurrent inactivation of the tumour suppressor RIZ1 suggests that this event may be a significant contributing factor to tumour development in pheochromocytomas and abdominal paragangliomas. ..
  29. Mansouri M, Marklund L, Gustavsson P, Davey E, Carlsson B, Larsson C, et al. Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation. Eur J Hum Genet. 2005;13:970-7 pubmed
    ..We suggest that the absence of the ZDHHC15 transcripts in this patient contributes to her phenotype, and that the gene is a strong candidate for nonsyndromic XLMR. ..
  30. Foukakis T, Au A, Wallin G, Geli J, Forsberg L, Clifton Bligh R, et al. The Ras effector NORE1A is suppressed in follicular thyroid carcinomas with a PAX8-PPARgamma fusion. J Clin Endocrinol Metab. 2006;91:1143-9 pubmed
    ..No NORE1A promoter methylation was detected in the 32 thyroid tumors analyzed. Our experiments demonstrate the suppression of NORE1A, a known Ras effector, in PAX8-PPARgamma carrying FTCs. ..
  31. Liu H, Xue Z, Sjogren H, Salford L, Widegren B. Low dose Zebularine treatment enhances immunogenicity of tumor cells. Cancer Lett. 2007;257:107-15 pubmed
    ..This immunosuppression should be considered when cancer is treated with Zebularine or drugs acting in a similar way. ..
  32. Geli J, Kogner P, Lanner F, Natalishvili N, Juhlin C, Kiss N, et al. Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma. Int J Cancer. 2008;123:389-394 pubmed publisher
    ..Promotor methylation is not a common mechanism responsible for NORE1A transcriptional suppression in this tumor type. ..
  33. Caren H, Djos A, Nethander M, Sjöberg R, Kogner P, Enström C, et al. Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma. BMC Cancer. 2011;11:66 pubmed publisher
    ..It is likely that analysis of specific DNA methylation will be one of several methods in future patient therapy stratification protocols for treatment of childhood neuroblastomas. ..
  34. Löf Öhlin Z, Nilsson T. Pyrosequencing assays to study promoter CpG site methylation of the O6-MGMT, hMLH1, p14ARF, p16INK4a, RASSF1A, and APC1A genes. Oncol Rep. 2009;21:721-9 pubmed
    ..This approach provides a more comprehensive picture of the distribution of DNA methylation throughout the promoter regions of the studied set of six genes, which will be of benefit in oncological research. ..
  35. Gillberg L, Jacobsen S, Rönn T, Brøns C, Vaag A. PPARGC1A DNA methylation in subcutaneous adipose tissue in low birth weight subjects--impact of 5 days of high-fat overfeeding. Metabolism. 2014;63:263-71 pubmed publisher
    ..Further data are needed to understand the role of PPARGC1A DNA methylation in insulin resistance and developmental programming of T2D. ..
  36. Zhuang S, Schippert A, Haugen Strano A, Wiseman R, Soderkvist P. Inactivations of p16INK4a-alpha, p16INK4a-beta and p15INK4b genes in 2',3'-dideoxycytidine- and 1,3-butadiene-induced murine lymphomas. Oncogene. 1998;16:803-8 pubmed
  37. Asting A, Caren H, Andersson M, Lönnroth C, Lagerstedt K, Lundholm K. COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status. BMC Cancer. 2011;11:238 pubmed publisher
  38. Thakur N, Kanduri M, Holmgren C, Mukhopadhyay R, Kanduri C. Bidirectional silencing and DNA methylation-sensitive methylation-spreading properties of the Kcnq1 imprinting control region map to the same regions. J Biol Chem. 2003;278:9514-9 pubmed
  39. Strömqvist M, Tooke N, Brunström B. DNA methylation levels in the 5' flanking region of the vitellogenin I gene in liver and brain of adult zebrafish (Danio rerio)--sex and tissue differences and effects of 17alpha-ethinylestradiol exposure. Aquat Toxicol. 2010;98:275-281 pubmed publisher
    ..These results suggest that induced expression of vitellogenin in fish following exposure to estrogens might involve alterations in DNA methylation. ..
  40. Kiss N, Geli J, Lundberg F, Avci C, Velazquez Fernandez D, Hashemi J, et al. Methylation of the p16INK4A promoter is associated with malignant behavior in abdominal extra-adrenal paragangliomas but not pheochromocytomas. Endocr Relat Cancer. 2008;15:609-21 pubmed publisher
    ..This finding suggests an etiological link and could provide a clinical utility for diagnostic purposes. ..
  41. Andreasson A, Kiss N, Caramuta S, Sulaiman L, Svahn F, Bäckdahl M, et al. The VHL gene is epigenetically inactivated in pheochromocytomas and abdominal paragangliomas. Epigenetics. 2013;8:1347-54 pubmed publisher
    ..Our results show that the VHL gene promoter has increased methylation compared with normal adrenals (MetI>50%) in approximately 75% of PCCs and PGLs investigated, highlighting the role of VHL in the development of these tumors. ..
  42. Jäwert F, Hassèus B, Kjeller G, Magnusson B, Sand L, Larsson L. Loss of 5-hydroxymethylcytosine and TET2 in oral squamous cell carcinoma. Anticancer Res. 2013;33:4325-8 pubmed
    ..In contrast, there was a significant increase in 5mC expression in OSCC compared to healthy epithelium. Our results indicate that loss of 5hmC is an epigenetic event of OSCC. ..
  43. Barres R, Kirchner H, Rasmussen M, Yan J, Kantor F, Krook A, et al. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep. 2013;3:1020-7 pubmed publisher
    ..Our results provide evidence that obesity and RYGB-induced weight loss have a dynamic effect on the epigenome...
  44. Yang B, Dayeh T, Volkov P, Kirkpatrick C, Malmgren S, Jing X, et al. Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes. Mol Endocrinol. 2012;26:1203-12 pubmed publisher
    ..The expression levels of PDX-1 were further associated with insulin secretion in the human islets. ..
  45. Caren H, Fransson S, Ejeskär K, Kogner P, Martinsson T. Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. Br J Cancer. 2007;97:1416-24 pubmed
    ..None of the variations above were found in healthy control individuals. In conclusion, of the 30 genes analysed, the PIK3CD gene stands out as one of the most interesting for further studies of NB development and progression. ..
  46. Djos A, Martinsson T, Kogner P, Caren H. The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma. Mol Cancer. 2012;11:40 pubmed publisher
    ..This study shows that several genes belonging to the RASSF gene family are methylated in neuroblastoma. The genes RASSF5, RASSF6 and RASSF7 stand out as the most promising candidate genes for further investigations in neuroblastoma. ..
  47. Kacevska M, Ivanov M, Wyss A, Kasela S, Milani L, Rane A, et al. DNA methylation dynamics in the hepatic CYP3A4 gene promoter. Biochimie. 2012;94:2338-44 pubmed publisher
    ..The findings provide novel insight to CYP3A4 regulation with possible implications for understanding interindividual differences in drug response. ..
  48. Tammimies K, Tapia Paez I, Rüegg J, Rosin G, Kere J, Gustafsson J, et al. The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor ? and DNA methylation. Mol Endocrinol. 2012;26:619-29 pubmed publisher
    ..Our data provide important molecular insights into the relationship between developmental dyslexia susceptibility and estrogen signaling...
  49. Davidsson J, Lilljebjörn H, Andersson A, Veerla S, Heldrup J, Behrendtz M, et al. The DNA methylome of pediatric acute lymphoblastic leukemia. Hum Mol Genet. 2009;18:4054-65 pubmed publisher
  50. Wettergren Y, Odin E, Carlsson G, Gustavsson B. MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer. Mol Med. 2010;16:425-32 pubmed publisher
    ..These results indicate a relationship between genetic germ-line variants of the MTRR gene and p16 hypermethylation in mucosa, which may affect the clinical outcome of patients with colorectal cancer. ..