Experts and Doctors on dna damage in Netherlands


Locale: Netherlands
Topic: dna damage

Top Publications

  1. Vogel E, Nivard M, Ballering L, Bartsch H, Barbin A, Nair J, et al. DNA damage and repair in mutagenesis and carcinogenesis: implications of structure-activity relationships for cross-species extrapolation. Mutat Res. 1996;353:177-218 pubmed
    ..One main reason for this is the complication due to uneven distribution in the body, with effects on the dose in target tissues. The estimation can be impro ..
  2. Houtsmuller A, Rademakers S, Nigg A, Hoogstraten D, Hoeijmakers J, Vermeulen W. Action of DNA repair endonuclease ERCC1/XPF in living cells. Science. 1999;284:958-61 pubmed
  3. de Boer J, Andressoo J, de Wit J, Huijmans J, Beems R, van Steeg H, et al. Premature aging in mice deficient in DNA repair and transcription. Science. 2002;296:1276-9 pubmed
    ..We hypothesize that aging in TTD mice is caused by unrepaired DNA damage that compromises transcription, leading to functional inactivation of critical genes and enhanced apoptosis...
  4. van den Boom V, Citterio E, Hoogstraten D, Zotter A, Egly J, van Cappellen W, et al. DNA damage stabilizes interaction of CSB with the transcription elongation machinery. J Cell Biol. 2004;166:27-36 pubmed
    ..These findings are consistent with a model in which CSB monitors progression of transcription by regularly probing elongation complexes and becomes more tightly associated to these complexes when TCR is active. ..
  5. Luijsterburg M, Dinant C, Lans H, Stap J, Wiernasz E, Lagerwerf S, et al. Heterochromatin protein 1 is recruited to various types of DNA damage. J Cell Biol. 2009;185:577-86 pubmed publisher
    ..Our results show that HP1 proteins are important for DNA repair and may function to reorganize chromatin in response to damage. ..
  6. Marteijn J, Bekker Jensen S, Mailand N, Lans H, Schwertman P, Gourdin A, et al. Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response. J Cell Biol. 2009;186:835-47 pubmed publisher
    ..Although both lesions are processed by independent repair pathways and trigger signaling responses by distinct kinases, they eventually generate the same epigenetic mark, possibly functioning in DNA damage signal amplification. ..
  7. Kupper N, Gidron Y, Winter J, Denollet J. Association between type D personality, depression, and oxidative stress in patients with chronic heart failure. Psychosom Med. 2009;71:973-80 pubmed publisher
    ..83, p = .03, d = 0.39), independent of etiology class. CHF patients with Type D personality are characterized by an increased oxidative stress burden, apparent in the decreased antioxidant levels and an increased oxidative stress ratio. ..
  8. Smeenk G, Wiegant W, Vrolijk H, Solari A, Pastink A, van Attikum H. The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage. J Cell Biol. 2010;190:741-9 pubmed publisher
    ..Finally, we show that CHD4 promotes DSB repair and checkpoint activation in response to IR. Thus, the NuRD chromatin-remodeling complex is a novel regulator of DNA damage responses that orchestrates proper signaling and repair of DSBs. ..
  9. Bergink S, Toussaint W, Luijsterburg M, Dinant C, Alekseev S, Hoeijmakers J, et al. Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex. J Cell Biol. 2012;196:681-8 pubmed publisher
    ..Furthermore, we show that RAD23 proteins rapidly dissociated from XPC upon binding to damaged DNA. Our data suggest that RAD23 proteins facilitate lesion recognition by XPC but do not participate in the downstream DNA repair process. ..

More Information


  1. Kruiswijk F, Yuniati L, Magliozzi R, Low T, Lim R, Bolder R, et al. Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress. Sci Signal. 2012;5:ra40 pubmed publisher
    ..Our study therefore establishes a link between DNA damage signaling and translation elongation. ..
  2. Janssen A, Medema R. Genetic instability: tipping the balance. Oncogene. 2013;32:4459-70 pubmed publisher
    ..Here, we review the mechanisms that can cause gross chromosomal aberrations, and discuss how these affect tumor cell viability. ..
  3. Shaltiƫl I, Aprelia M, Saurin A, Chowdhury D, Kops G, Voest E, et al. Distinct phosphatases antagonize the p53 response in different phases of the cell cycle. Proc Natl Acad Sci U S A. 2014;111:7313-8 pubmed publisher
    ..Taken together, our results show that PP4 and Wip1 are differentially required to counteract the p53-dependent cell cycle arrest in G1 and G2, by antagonizing early or late p53-mediated responses, respectively. ..