Experts and Doctors on dna damage in Japan

Summary

Locale: Japan
Topic: dna damage

Top Publications

  1. Watanabe T, Bando T, Xu Y, Tashiro R, Sugiyama H. Efficient generation of 2'-deoxyuridin-5-yl at 5'-(G/C)AA(X)U(X)U-3' (X = Br, I) sequences in duplex DNA under UV irradiation. J Am Chem Soc. 2005;127:44-5 pubmed
    ..These observations will be useful in studying the molecular basis of the sequence-dependent DNA-damaging process in UV-irradiated 5-halouracil-containing DNA. ..
  2. Kurebayashi J, Kanomata N, Moriya T, Kozuka Y, Watanabe M, Sonoo H. Preferential antitumor effect of the Src inhibitor dasatinib associated with a decreased proportion of aldehyde dehydrogenase 1-positive cells in breast cancer cells of the basal B subtype. BMC Cancer. 2010;10:568 pubmed publisher
    ..A combined use of dasatinib with etoposide additively inhibits their growth. Further studies targeting breast cancers of the basal B subtype using dasatinib with cytotoxic agents are warranted. ..
  3. Abe K, Osakabe K, Ishikawa Y, Tagiri A, Yamanouchi H, Takyuu T, et al. Inefficient double-strand DNA break repair is associated with increased fasciation in Arabidopsis BRCA2 mutants. J Exp Bot. 2009;60:2751-61 pubmed publisher
    ..These data suggest that inefficient DSB repair in the atbrca2a-1/atbrca2b-1 mutant leads to disorganization of the programmed cell cycle of apical meristems. ..
  4. Kasai M, Matsuzaki T, Katayanagi K, Omori A, Maziarz R, Strominger J, et al. The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome. J Biol Chem. 1997;272:11402-7 pubmed
    ..The results support the hypothesis that staggered breaks occur at recombination hot spots and Translin has a pivotal function in recognition of the generated single-stranded DNA ends. ..
  5. Kawamoto T, Araki K, Sonoda E, Yamashita Y, Harada K, Kikuchi K, et al. Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis. Mol Cell. 2005;20:793-9 pubmed
    ..Our findings identify a DNA polymerase that carries out DNA synthesis for physiological HR and provides evidence that a single DNA polymerase can play multiple cellular roles. ..
  6. Iijima K, Muranaka C, Kobayashi J, Sakamoto S, Komatsu K, Matsuura S, et al. NBS1 regulates a novel apoptotic pathway through Bax activation. DNA Repair (Amst). 2008;7:1705-16 pubmed publisher
    ..Thus, NBS1 is a key protein involved in the prevention of carcinogenesis, not only through the precise repair of damaged DNA by homologous recombination (HR) but also by its role in the elimination of inappropriately repaired cells. ..
  7. Yamamoto K, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, et al. Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environ Mol Mutagen. 2011;52:547-61 pubmed publisher
    ..The results demonstrate the utility of this DT40 screen for detecting genotoxic compounds, for characterizing the nature of the DNA damage, and potentially for analyzing mechanisms of mutagenesis. ..
  8. Nakano T, Ouchi R, Kawazoe J, Pack S, Makino K, Ide H. T7 RNA polymerases backed up by covalently trapped proteins catalyze highly error prone transcription. J Biol Chem. 2012;287:6562-72 pubmed publisher
    ..The present results provide new insights into the transcriptional fidelity and mutual interactions of RNAPs that encounter persistent roadblocks...
  9. Kawamoto K, Oashi T, Oami K, Liu W, Jin Y, Saito N, et al. Perfluorooctanoic acid (PFOA) but not perfluorooctane sulfonate (PFOS) showed DNA damage in comet assay on Paramecium caudatum. J Toxicol Sci. 2010;35:835-41 pubmed
    ..In conclusion, the PFOA-induced in vivo DNA damage was first shown in paramecia, and the DNA damage might not be directly attributable to increase in intracellular ROS. ..

More Information

Publications127 found, 100 shown here

  1. Oyadomari S, Takeda K, Takiguchi M, Gotoh T, Matsumoto M, Wada I, et al. Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A. 2001;98:10845-50 pubmed
    ..We conclude that NO depletes ER Ca(2+), causes ER stress, and leads to apoptosis. Thus, ER Ca(2+) stores are a new target of NO, and the ER stress pathway is a major mechanism of NO-mediated beta cell apoptosis. ..
  2. Ozawa S, Suzuki H, Yamaki H, Nishimura T, Tanaka N. A peplomycin-supersensitive cell line lacking activation of poly(adenosine diphosphate ribose) synthetase by peplomycin. Biochem Biophys Res Commun. 1988;151:1305-11 pubmed
    ..Relationship between poly(ADP-ribose) polymerase and peplomycin sensitivity was discussed. ..
  3. Otsuka C, Kunitomi N, Iwai S, Loakes D, Negishi K. Roles of the polymerase and BRCT domains of Rev1 protein in translesion DNA synthesis in yeast in vivo. Mutat Res. 2005;578:79-87 pubmed
    ..The effect of Poleta was also analyzed. From all the results DNA polymerases other than these two translesion polymerases, too, seem to initiate the translesion synthesis. ..
  4. Asai H, Hirano M, Shimada K, Kiriyama T, Furiya Y, Ikeda M, et al. Protein kinase C gamma, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin. Hum Mol Genet. 2009;18:3533-43 pubmed publisher
    ..Decreased nuclear APTX increased oxidative stress-induced DNA damage and cell death. Phosphorylation-resistant APTX, kinase inhibitors, and antioxidants may be therapeutic options for SCA14. ..
  5. Yamada H, Miyahara T, Kozuka H, Matsuhashi T, Sasaki Y. Potentiating effects of organomercuries on clastogen-induced chromosome aberrations in cultured Chinese hamster cells. Mutat Res. 1993;290:281-91 pubmed
  6. Kiyomiya K, Satoh J, Horie H, Kurebe M, Nakagawa H, Matsuo S. Correlation between nuclear action of anthracycline anticancer agents and their binding affinity to the proteasome. Int J Oncol. 2002;21:1081-5 pubmed
    ..These results suggest that the binding affinity of these anticancer agents to the proteasome is an important factor in their transport to the nucleus and determines their specificity of action for the nuclear DNA. ..
  7. Komichi D, Tazuma S, Nishioka T, Hyogo H, Chayama K. Glycochenodeoxycholate plays a carcinogenic role in immortalized mouse cholangiocytes via oxidative DNA damage. Free Radic Biol Med. 2005;39:1418-27 pubmed
    ..Furthermore, accumulation of 8-OHdG due to GCDC might contribute to the dysfunction of oxidative DNA repair enzymes. ..
  8. Kano M, Matsushita K, Rahmutulla B, Yamada S, Shimada H, Kubo S, et al. Adenovirus-mediated FIR demonstrated TP53-independent cell-killing effect and enhanced antitumor activity of carbon-ion beams. Gene Ther. 2016;23:50-6 pubmed publisher
    ..Our findings indicated the feasibility of the combination of Ad-FIR with DNA damaging agents for future esophageal cancer treatment. ..
  9. Kashige N, Kakita Y, Nakashima Y, Miake F, Watanabe K. Mechanism of the photocatalytic inactivation of Lactobacillus casei phage PL-1 by titania thin film. Curr Microbiol. 2001;42:184-9 pubmed
    ..BL-catalytic TiO2 film was considered to cause primarily the damage to the capsid protein through the generation of active oxygen species such as *OH, followed by damage to the genome DNA inside the phage particles. ..
  10. Ohmori H, Saito M, Yasuda T, Nagata T, Fujii T, Wachi M, et al. The pcsA gene is identical to dinD in Escherichia coli. J Bacteriol. 1995;177:156-65 pubmed
    ..We discuss the possible function of the pcsA gene, comparing it with the sulA or the dif-xerCD function. We also describe a new method for gene disruption with positive and negative selection. ..
  11. Watanabe M, Henmi K, Ogawa K, Suzuki T. Cadmium-dependent generation of reactive oxygen species and mitochondrial DNA breaks in photosynthetic and non-photosynthetic strains of Euglena gracilis. Comp Biochem Physiol C Toxicol Pharmacol. 2003;134:227-34 pubmed
    ..The results suggest that the mitochondrion is the primary target organelle of Cd in E. gracilis cells...
  12. Arai T, Kelly V, Komoro K, Minowa O, Noda T, Nishimura S. Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA. Cancer Res. 2003;63:4287-92 pubmed
    ..These results showed that inactivation of the Ogg1 gene leads to a higher risk of cancer because cells with accumulated 8-OH-G still retain the ability to proliferate, leading to an increase in the mutation frequency. ..
  13. Arai T, Kelly V, Minowa O, Noda T, Nishimura S. The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA. Toxicology. 2006;221:179-86 pubmed
    ..A possible explanation is presented to reconcile these results with those of others which showed an increased incidence of tumor formation in untreated Ogg1(-/-) mice. ..
  14. Suzuki K, Dashzeveg N, Lu Z, Taira N, Miki Y, Yoshida K. Programmed cell death 6, a novel p53-responsive gene, targets to the nucleus in the apoptotic response to DNA damage. Cancer Sci. 2012;103:1788-94 pubmed publisher
    ..Therefore, we conclude that a novel p53-responsive gene PDCD6 is accumulated in the nucleus and induces apoptosis in response to DNA damage. ..
  15. Nozaki T, Masutani M, Sugimura T, Takato T, Wakabayashi K. Abrogation of G1 arrest after DNA damage is associated with constitutive overexpression of Mdm2, Cdk4, and Irf1 mRNAs in the BALB/c 3T3 A31 variant 1-1 clone. Biochem Biophys Res Commun. 1997;233:216-20 pubmed
  16. Min K. [Physiological significance of metallothionein in oxidative stress]. Yakugaku Zasshi. 2007;127:695-702 pubmed
    ..Moreover, Cd released from MT after an injection of Fe-NTA induced new MT protein again. Thus MT may act as a secondary antioxidant in cellular protection system against oxidative stress. ..
  17. Kawachi Y, Xu X, Taguchi S, Sakurai H, Nakamura Y, Ishii Y, et al. Attenuation of UVB-induced sunburn reaction and oxidative DNA damage with no alterations in UVB-induced skin carcinogenesis in Nrf2 gene-deficient mice. J Invest Dermatol. 2008;128:1773-9 pubmed publisher
    ..Journal of Investigative Dermatology (2008) 128, 1773-1779; doi:10.1038/sj.jid.5701245; published online 17 January 2008. ..
  18. Nasuno T, Mimaki S, Okamoto M, Esumi H, Tsuchihara K. Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines. Cancer Sci. 2014;105:202-10 pubmed publisher
    ..5345). Because the assessment of basal DSB status could serve as a biomarker for selecting PARP inhibitor-tractable tumors, further investigation is warranted. ..
  19. Uchida S, Watanabe N, Kudo Y, Yoshioka K, Matsunaga T, Ishizaka Y, et al. SCF?(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation. J Cell Sci. 2011;124:2816-25 pubmed publisher
    ..Collectively, these results indicate that stress-induced Cdc25B ubiquitylation by SCF(?TrCP) requires the phosphorylation of S(101)PS(103)P in the ?TrCP-binding-motif-like and adjacent PEST-like sequences. ..
  20. Nanashima A, Izumino H, Sumida Y, Tominaga T, Wakata K, Hidaka S, et al. Relationship Between Urinary 8-hydroxydeoxyguanine (8-OHdG) Levels and Clinicopathological Findings in Hepatobiliary Malignancies. Anticancer Res. 2016;36:3899-903 pubmed
    ..Further studies are necessary to clarify the relationship between node metastasis and oxidative stress as a prognostic marker. ..
  21. Taira K, Miyashita Y, Okamoto K, Arimoto S, Takahashi E, Negishi T. Novel antimutagenic factors derived from the edible mushroom Agrocybe cylindracea. Mutat Res. 2005;586:115-23 pubmed
    ..The data suggest that there is a novel antigenotoxic factor(s) in A. cylindracea, possibly in the form of a peptide or protein. ..
  22. Horai Y, Ando Y, Kimura S, Arimoto Kobayashi S. Mutation spectrum resulting in M13mp2 phage DNA exposed to N-nitrosoproline with UVA irradiation. Mutat Res. 2017;821:1-4 pubmed publisher
    ..Non-clustering of the GC to CG mutations suggests that NPRO+UVA damage to DNA is random. These transversions may be caused by guanine adducts in DNA or in part by oxidatively modified guanine in DNA exposed to NPRO and UVA. ..
  23. Tano K, Nakamura J, Asagoshi K, Arakawa H, Sonoda E, Braithwaite E, et al. Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. DNA Repair (Amst). 2007;6:869-75 pubmed
    ..A strong hypersensitivity and reduction in BER capacity was observed for Pol beta(-/-)/Pol lambda(-/-) and Pol beta(-/-) cells, suggesting that Pol beta had a dominant role in counteracting alkylation DNA damage in this cell system. ..
  24. Abe Y, Oda Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, et al. Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2. Proc Natl Acad Sci U S A. 2008;105:4838-43 pubmed publisher
    ..Therefore, the Hh pathway may be a powerful accelerator of oncogenesis by activating cell proliferation and inhibiting the p53-mediated anti-cancer barrier induced by oncogenic stress. ..
  25. Nagai A, Saijo M, Kuraoka I, Matsuda T, Kodo N, Nakatsu Y, et al. Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein. Biochem Biophys Res Commun. 1995;211:960-6 pubmed
    ..These results suggest that the XPA/ERCC1 interaction may participate in damage-recognition as well as in incision at the 5' site of damage during nucleotide excision repair. ..
  26. Nakamura K, Sakai W, Kawamoto T, Bree R, Lowndes N, Takeda S, et al. Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks. DNA Repair (Amst). 2006;5:741-9 pubmed
    ..We conclude that the major role of 53BP1 in supporting survival of DT40 cells that have suffered DNA DSBs is in facilitating repair by NHEJ. ..
  27. Matsuoka M, Jeang K. Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer. 2007;7:270-80 pubmed
    ..We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand, HTLV-1 basic leucine zipper factor (HBZ), to the maintenance of virus-induced leukaemia...
  28. Liu J, Cao L, Chen J, Song S, Lee I, Quijano C, et al. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature. 2009;459:387-392 pubmed publisher
  29. Hirai H, Arai T, Okada M, Nishibata T, Kobayashi M, Sakai N, et al. MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil. Cancer Biol Ther. 2010;9:514-22 pubmed
    ..These studies support the rationale for testing the combination of MK-1775 with various DNA-damaging agents in cancer patients. ..
  30. Shinagawa H, Iwasaki H, Kato T, Nakata A. RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis. Proc Natl Acad Sci U S A. 1988;85:1806-10 pubmed
    ..The results suggested that UmuD protein may be proteolytically processed by RecA, and that processed UmuD may be the active form of the protein participating in mutagenesis. ..
  31. Matsumoto H, Takakusu A, Mori T, Ihara M, Todo T, Ohnishi T. Preferential inhibition of nucleosome assembly by ultraviolet-induced (6-4)photoproducts. Photochem Photobiol. 1995;61:459-62 pubmed
    ..e. linker-like conformation until completion of the repair processes. ..
  32. Yamamoto H, Mohanan P. Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro. Toxicology. 2002;179:29-36 pubmed
    ..Hence, the present study concluded that melatonin protects against DNA damage induced by the *OH produced by cyanide or hydrogen peroxide...
  33. Takeuchi R, Oshige M, Uchida M, Ishikawa G, Takata K, Shimanouchi K, et al. Purification of Drosophila DNA polymerase zeta by REV1 protein-affinity chromatography. Biochem J. 2004;382:535-43 pubmed
    ..The present study is the first report about characterization of purified pol zeta from multicellular organisms, and the second concerning the characterization of yeast pol zeta. ..
  34. Inomata K, Aoto T, Binh N, Okamoto N, Tanimura S, Wakayama T, et al. Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell. 2009;137:1088-99 pubmed publisher
  35. Nakajima W, Tanaka N. Noxa induces apoptosis in oncogene-expressing cells through catch-and-release mechanism operating between Puma and Mcl-1. Biochem Biophys Res Commun. 2011;413:643-8 pubmed publisher
    ..Accumulated Puma by oncogene enhances susceptibility to apoptosis through "catch" in mitochondria by Mcl-1. Subsequently, in response to DNA-damage, Noxa efficiently induces apoptosis by "release" of Puma from Mcl-1. ..
  36. Ide H, Tedzuka K, Shimzu H, Kimura Y, Purmal A, Wallace S, et al. Alpha-deoxyadenosine, a major anoxic radiolysis product of adenine in DNA, is a substrate for Escherichia coli endonuclease IV. Biochemistry. 1994;33:7842-7 pubmed
    ..The ability of endonuclease IV to recognize alpha-deoxyadenosine suggests that endonuclease IV is able to recognize a new class of DNA base lesions that is not recognized by other DNA N-glycosylases and AP endonucleases. ..
  37. Ikeda S, Ozaki K. Action of mitochondrial endonuclease G on DNA damaged by L-ascorbic acid, peplomycin, and cis-diamminedichloroplatinum (II). Biochem Biophys Res Commun. 1997;235:291-4 pubmed
    ..These nucleolytic properties of Endo G in vitro suggest its possible involvement in the maintenance of mtDNA by eliminating defective genomes from the multicopy pool. ..
  38. Kawakami K, Nishida H, Tatewaki N, Nakajima Y, Konishi T, Hirayama M. Persimmon leaf extract inhibits the ATM activity during DNA damage response induced by Doxorubicin in A549 lung adenocarcinoma cells. Biosci Biotechnol Biochem. 2011;75:650-5 pubmed
    ..These results suggest that PLEg specifically inhibited ATM-dependent checkpoint activation by DOX, and that PLEg might be a useful sensitizer in cancer chemotherapy. ..
  39. Adachi S, Minamisawa K, Okushima Y, Inagaki S, Yoshiyama K, Kondou Y, et al. Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis. Proc Natl Acad Sci U S A. 2011;108:10004-9 pubmed publisher
    ..Our results demonstrate that Arabidopsis undergoes a programmed endoreduplicative response to DSBs, suggesting that plants have evolved a distinct strategy to sustain growth under genotoxic stress. ..
  40. Fujikawa K, Hasegawa Y, Matsuzawa S, Fukunaga A, Itoh T, Kondo S. Dose and dose-rate effects of X rays and fission neutrons on lymphocyte apoptosis in p53(+/+) and p53(-/-) mice. J Radiat Res. 2000;41:113-27 pubmed
    ..4 Gy/min) and chronic (3 mGy/min) gamma-irradiations. Namely, radiation-induced apoptosis in lymphocytes is a dose-rate independent event. ..
  41. Shin S. Influence of the origin and level of dietary protein on TBI-induced oxidative damage in mice. Int J Vitam Nutr Res. 2003;73:297-302 pubmed
    ..Mice fed a low-protein diet became susceptible to TBI-induced oxidative damage regardless of the origin of protein. Vitamin C and E values of the soybean protein group were markedly lower than those of the casein group. ..
  42. Uchida Y, Hirayama J, Nishina H. A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses. Biol Pharm Bull. 2010;33:535-44 pubmed
  43. Weng Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, et al. Differential genotoxic effects of subchronic exposure to ethyl tertiary butyl ether in the livers of Aldh2 knockout and wild-type mice. Arch Toxicol. 2012;86:675-82 pubmed publisher
    ..Thus, sex differences in DNA damage were found not only in KO mice, but also in WT mice. These results suggest that ALDH2 polymorphisms and sex should be taken into considerations in predicting human health effects of ETBE exposure. ..
  44. Okada T, Kashino G, Nishiura H, Tano K, Watanabe M. Micronuclei formation induced by X-ray irradiation does not always result from DNA double-strand breaks. J Radiat Res. 2012;53:93-100 pubmed
    ..Therefore, we conclude that DNA DSBs induced in the G1 phase do not directly lead to micronucleus formation. ..
  45. Luo L, Kawakatsu M, Guo C, Urata Y, Huang W, Ali H, et al. Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells. Sci Rep. 2014;4:3779 pubmed publisher
    ..Long-term culture will be necessary to confirm whether low dose antioxidants improve the quality and genomic stability of iPS cells. ..
  46. Hirakawa K, Mori M, Yoshida M, Oikawa S, Kawanishi S. Photo-irradiated titanium dioxide catalyzes site specific DNA damage via generation of hydrogen peroxide. Free Radic Res. 2004;38:439-47 pubmed
    ..This DNA-damaging mechanism may participate in the phototoxicity of TiO2. ..
  47. Nakano T, Asagoshi K, Terato H, Suzuki T, Ide H. Assessment of the genotoxic potential of nitric oxide-induced guanine lesions by in vitro reactions with Escherichia coli DNA polymerase I. Mutagenesis. 2005;20:209-16 pubmed
  48. Abe K, Osakabe K, Nakayama S, Endo M, Tagiri A, Todoriki S, et al. Arabidopsis RAD51C gene is important for homologous recombination in meiosis and mitosis. Plant Physiol. 2005;139:896-908 pubmed
    ..The efficiency of homologous recombination in somatic cells in the mutant was markedly reduced relative to that in wild-type plants. ..
  49. Kawatani Y, Igarashi H, Matsui T, Kuwahara K, Fujimura S, Okamoto N, et al. Cutting edge: double-stranded DNA breaks in the IgV region gene were detected at lower frequency in affinity-maturation impeded GANP-/- mice. J Immunol. 2005;175:5615-8 pubmed
    ..These results suggested that the level of IgV DSBs in germinal center B cells is associated with GANP expression, which is presumably required for B cell receptor affinity maturation. ..
  50. Nakadate Y, Kodera Y, Kitamura Y, Tachibana T, Tamura T, Koizumi F. Silencing of poly(ADP-ribose) glycohydrolase sensitizes lung cancer cells to radiation through the abrogation of DNA damage checkpoint. Biochem Biophys Res Commun. 2013;441:793-8 pubmed publisher
    ..Our findings indicate that PARG could be a potential target for lung cancer treatments when used in combination with radiotherapy. ..
  51. Takahashi E, Marczylo T, Watanabe T, Nagai S, Hayatsu H, Negishi T. Preventive effects of anthraquinone food pigments on the DNA damage induced by carcinogens in Drosophila. Mutat Res. 2001;480-481:139-45 pubmed
    ..Since purpurin and alizarin suppressed the activity of MNU, a direct alkylating agent, there may also be a mechanism distinct from enzyme inhibitions in these anthraquinone-mediated suppressions of DNA damage. ..
  52. Kobayashi M, Ono H, Mihara K, Tauchi H, Komatsu K, Shibata T, et al. ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. Genes Cells. 2006;11:779-89 pubmed
    ..These results indicate that ATM is activated through the direct modification of its SH groups, independent of DNA damage, and this activation leads, downstream, to apoptosis. ..
  53. Kurokawa R. Promoter-associated long noncoding RNAs repress transcription through a RNA binding protein TLS. Adv Exp Med Biol. 2011;722:196-208 pubmed publisher
    ..Taken together, TLS is a unique mediator between signals of the long ncRNAs and transcription, suggesting that RNA networking functions in living cells.(1-3). ..
  54. Aoshiba K, Tsuji T, Kameyama S, Itoh M, Semba S, Yamaguchi K, et al. Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury. Exp Toxicol Pathol. 2013;65:1053-62 pubmed publisher
  55. Shikazono N, Pearson C, O Neill P, Thacker J. The roles of specific glycosylases in determining the mutagenic consequences of clustered DNA base damage. Nucleic Acids Res. 2006;34:3722-30 pubmed
    ..Recovered plasmids commonly gave rise to both wild-type and mutant progeny, suggesting that there is differential replication of the two DNA strands carrying specific forms of base damage. ..
  56. Tsujioka T, Yokoi A, Uesugi M, Kishimoto M, Tochigi A, Suemori S, et al. Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell lines. Exp Hematol. 2013;41:189-97 pubmed publisher
    ..We conclude that this study provides in vitro models for understanding the effects of DNMTIs on cell growth and gene regulation, including differences in the possible action mechanism of DAC and AZA. ..
  57. Kohda K, Tada M, Hakura A, Kasai H, Kawazoe Y. Formation of 8-hydroxyguanine residues in DNA treated with 4-hydroxyaminoquinoline 1-oxide and its related compounds in the presence of seryl-AMP. Biochem Biophys Res Commun. 1987;149:1141-8 pubmed
    ..The amount of 8-OH-Gua varied depending on the structure of 4HAQO analogues and that of DNA. The formation of 8-OH-Gua was not inhibited by active oxygen scavengers. Possible mechanisms are discussed...
  58. Todo T, Takemori H, Ryo H, Ihara M, Matsunaga T, Nikaido O, et al. A new photoreactivating enzyme that specifically repairs ultraviolet light-induced (6-4)photoproducts. Nature. 1993;361:371-4 pubmed
    ..This is, to our knowledge, the first report of such photoreactivating activity specific for (6-4)photoproducts in any organism. ..
  59. Esashi F, Yanagida M. Cdc2 phosphorylation of Crb2 is required for reestablishing cell cycle progression after the damage checkpoint. Mol Cell. 1999;4:167-74 pubmed
    ..The T215 site is in vitro phosphorylated by purified Cdc2 kinase. Phosphorylation of T215 occurs intensely in response to DNA damage at a late stage, suggesting an antagonistic role of Cdc2 phosphorylation toward checkpoint. ..
  60. Araki M, Masutani C, Takemura M, Uchida A, Sugasawa K, Kondoh J, et al. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J Biol Chem. 2001;276:18665-72 pubmed
    ..CEN2 has been shown to play an important role in centrosome duplication. Thus, those findings suggest that the XPC-CEN2 interaction may reflect coupling of cell division and NER. ..
  61. Ochi K, Mori T, Toyama Y, Nakamura Y, Arakawa H. Identification of semaphorin3B as a direct target of p53. Neoplasia. 2002;4:82-7 pubmed
    ..These results suggest that Sema3B might play some role in regulating cell growth as a mediator of p53 tumor-suppressor activity. ..
  62. Koyama H, Itoh M, Miyahara K, Tsuchiya E. Abundance of the RSC nucleosome-remodeling complex is important for the cells to tolerate DNA damage in Saccharomyces cerevisiae. FEBS Lett. 2002;531:215-21 pubmed
    ..These results suggest the importance of the Nps1p bromodomain in RSC integrity and a model in which high amounts of RSC would be required for the cells to overcome DNA damage. ..
  63. Jałoszyński P, Ohashi E, Ohmori H, Nishimura S. Error-prone and inefficient replication across 8-hydroxyguanine (8-oxoguanine) in human and mouse ras gene fragments by DNA polymerase kappa. Genes Cells. 2005;10:543-50 pubmed
    ..Interestingly, in direct mutagenesis systems, the preference for dAMP over dCMP was nearly the same on mouse and human templates. ..
  64. Yoshihara R, Imaki T, Hori M, Watanabe C, Yamamoto K, Takimoto K. CPD photolyase gene from Spinacia oleracea: repair of UV-damaged DNA and expression in plant organs. J Radiat Res. 2005;46:157-64 pubmed
    ..In both the male and female plants, the gene was highly expressed in leaves and flowers under the condition of 14-h light and 10-h dark cycle. The expression in the roots was quite low compared with the other organs...
  65. Saotome A, Kimura S, Mori Y, Uchiyama Y, Morohashi K, Sakaguchi K. Characterization of four RecQ homologues from rice (Oryza sativa L. cv. Nipponbare). Biochem Biophys Res Commun. 2006;345:1283-91 pubmed
  66. Wu W, Nishikawa H, Hayami R, Sato K, Honda A, Aratani S, et al. BRCA1 ubiquitinates RPB8 in response to DNA damage. Cancer Res. 2007;67:951-8 pubmed
    ..Our findings suggest that ubiquitination of a common subunit of RNA polymerases is a mechanism underlying BRCA1-dependent cell survival after DNA damage. ..
  67. Morita A, Tanimoto K, Murakami T, Morinaga T, Hosoi Y. Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells. Biochem Biophys Res Commun. 2014;443:1286-90 pubmed publisher
    ..These findings strongly suggest that ATM can be activated in response to oxidative stress in mitochondria and that this occurs in a DDR-independent manner. ..
  68. Masai H, Asai T, Kubota Y, Arai K, Kogoma T. Escherichia coli PriA protein is essential for inducible and constitutive stable DNA replication. EMBO J. 1994;13:5338-45 pubmed
    ..abstract truncated at 250 words) ..
  69. Shibahara T, Ogawa H, Ryo H, Fujikawa K. DNA-damaging potency and genotoxicity of aflatoxin M1 in somatic cells in vivo of Drosophila melanogaster. Mutagenesis. 1995;10:161-4 pubmed
    ..Based on these results and other data, we predict that AFM1 may be genotoxic in mammalian in-vivo systems as well. ..
  70. Kusano K, Takahashi N, Yoshikura H, Kobayashi I. Involvement of RecE exonuclease and RecT annealing protein in DNA double-strand break repair by homologous recombination. Gene. 1994;138:17-25 pubmed
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