Experts and Doctors on dna damage in Germany


Locale: Germany
Topic: dna damage

Top Publications

  1. van Dam H, Wilhelm D, Herr I, Steffen A, Herrlich P, Angel P. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 1995;14:1798-811 pubmed
    ..This allows fine tuned modulation of c-jun expression by a large spectrum of extracellular signals. ..
  2. Stühmer T, Chatterjee M, Hildebrandt M, Herrmann P, Gollasch H, Gerecke C, et al. Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma. Blood. 2005;106:3609-17 pubmed
    ..Therefore, MDM2 antagonists may offer a new treatment option for this disease. ..
  3. Kulms D, Zeise E, Poppelmann B, Schwarz T. DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way. Oncogene. 2002;21:5844-51 pubmed
    ..This indicates that DNA damage, death receptor activation and ROS formation contribute to UVB-induced apoptosis in an essential and independent way. ..
  4. Schleicher E, Hessling B, Illarionova V, Bacher A, Weber S, Richter G, et al. Light-induced reactions of Escherichia coli DNA photolyase monitored by Fourier transform infrared spectroscopy. FEBS J. 2005;272:1855-66 pubmed
    ..This study provides the basis for future time-resolved FT-IR studies which are aimed at an elucidation of a detailed molecular picture of the light-driven DNA repair process. ..
  5. Staszewski O, Nikolova T, Kaina B. Kinetics of gamma-H2AX focus formation upon treatment of cells with UV light and alkylating agents. Environ Mol Mutagen. 2008;49:734-40 pubmed publisher
    ..The data support that gamma-H2AX foci are a useful marker of DSBs that are induced by S-phase dependent genotoxins during replication. ..
  6. Fuchs F, Pau G, Kranz D, Sklyar O, Budjan C, Steinbrink S, et al. Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. Mol Syst Biol. 2010;6:370 pubmed publisher
    ..Multiparametric phenotyping by automated imaging and computational annotation is a powerful method for functional discovery and mapping the landscape of phenotypic responses to cellular perturbations. ..
  7. Hocke S, Guo Y, Job A, Orth M, Ziesch A, Lauber K, et al. A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers. Oncotarget. 2016;7:7080-95 pubmed publisher
    ..POLD1 deficiency might thus represent a predictive marker for treatment response towards ATR- or CHK1-inhibitors that are currently tested in clinical trials. ..
  8. Boon R, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, et al. MicroRNA-34a regulates cardiac ageing and function. Nature. 2013;495:107-10 pubmed publisher
  9. Kitanovic A, Wolfl S. Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae. Mutat Res. 2006;594:135-47 pubmed
    ..Our results indicate that FBP1 influences the connection between DNA damage, aging and oxidative stress through either direct signalling or an intricate adaptation in energy metabolism. ..

More Information

Publications264 found, 100 shown here

  1. Schneider E, Montenarh M, Wagner P. Regulation of CAK kinase activity by p53. Oncogene. 1998;17:2733-41 pubmed
  2. Zielinski B, Hergenhahn M. 2-Chloroacetaldehyde induces epsilondA DNA adducts in DNA of Raji cells as demonstrated by an improved HPLC-fluorimetry method. Fresenius J Anal Chem. 2001;370:97-100 pubmed
    ..Our method has a detection limit of 5 fmol which is one two-hundredth that of the original method. By use of this method initial evidence was found that cigarette smoke can also induce etheno dA adducts in Raji cell DNA. ..
  3. Kramer M, Kraft G. Track structure and DNA damage. Adv Space Res. 1994;14:151-9 pubmed
    ..The result of this calculation is compared to other models and used for a qualitative interpretation of the induction of DNA damage by particles. ..
  4. Speit G, Bonzheim I. Genotoxic and protective effects of hyperbaric oxygen in A549 lung cells. Mutagenesis. 2003;18:545-8 pubmed
    ..Our study indicates that A549 cells are an appropriate cell culture system for the evaluation of genetic effects induced by HBO in lung cells...
  5. Wiegand M, Bossow S, Neubert W. Sendai virus trailer RNA simultaneously blocks two apoptosis-inducing mechanisms in a cell type-dependent manner. J Gen Virol. 2005;86:2305-14 pubmed
    ..Thus, virus-expressed factors enabling a well-balanced ratio of suppression and triggering of apoptosis seem to be essential for optimal virus replication. ..
  6. Berg E, Christensen M, Dalla Rosa I, Wannagat E, Janicke R, Rösner L, et al. XRCC4 controls nuclear import and distribution of Ligase IV and exchanges faster at damaged DNA in complex with Ligase IV. DNA Repair (Amst). 2011;10:1232-42 pubmed publisher
  7. Balbach S, Esteves T, Houghton F, Siatkowski M, Pfeiffer M, Tsurumi C, et al. Nuclear reprogramming: kinetics of cell cycle and metabolic progression as determinants of success. PLoS ONE. 2012;7:e35322 pubmed publisher
    ..We conclude that a cell cycle delay, which is independent of pluripotency marker reactivation, and metabolic restraints reduce cell counts of NT embryos and impede their development. ..
  8. Kotzerke J, Wendisch M, Freudenberg R, Runge R, Oehme L, Meyer G, et al. Sodium-iodide symporter positive cells after intracellular uptake of (99m)Tc versus ?-emitter 211At. Reduction of clonogenic survival and characterization of DNA damage. Nuklearmedizin. 2012;51:170-8 pubmed publisher
    ..We evaluated the DNA damaging potential of Auger electrons emitted in the decay of (99m)Tc compared to ?-particles of 211At...
  9. van Berlo D, Clift M, Albrecht C, Schins R. Carbon nanotubes: an insight into the mechanisms of their potential genotoxicity. Swiss Med Wkly. 2012;142:w13698 pubmed publisher
    ..The involvement of other mechanisms generally implicated in particle toxicity, such as phagocyte activation and impairment of DNA repair, is largely unknown at present and needs further investigation. ..
  10. Perkhofer L, Schmitt A, Romero Carrasco M, Ihle M, Hampp S, Ruess D, et al. ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage. Cancer Res. 2017;77:5576-5590 pubmed publisher
    ..Overall, our results offered a preclinical mechanistic rationale for the use of PARP and ATR inhibitors to improve treatment of ATM-mutant PDAC. Cancer Res; 77(20); 5576-90. ©2017 AACR. ..
  11. Mönkemann H, De Vriese A, Blom H, Kluijtmans L, Heil S, Schild H, et al. Early molecular events in the development of the diabetic cardiomyopathy. Amino Acids. 2002;23:331-6 pubmed
    ..This pathway includes de novomethylation of the P53-inducible p21(WAF1/CIP1)-gene encoding a protein which binds to and inhibits a broad range of cyclin-cyclin-dependent kinase complexes. ..
  12. Yeghiazaryan K, Schild H, Golubnitschaja O. Chromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnostics. Infect Disord Drug Targets. 2012;12:332-9 pubmed
    ..Consequently, a multimodal approach of integrative medicine by predictive diagnostics, targeted prevention and individually created treatment algorithms is highly desirable. ..
  13. Cakmak G, Schins R, Shi T, Fenoglio I, Fubini B, Borm P. In vitro genotoxicity assessment of commercial quartz flours in comparison to standard DQ12 quartz. Int J Hyg Environ Health. 2004;207:105-13 pubmed
    ..Therefore, in vitro genotoxicity found here is unlikely to explain the genotoxicity observed in in vivo studies with the same and other quartzes. ..
  14. Christmann M, Tomicic M, Aasland D, Kaina B. A role for UV-light-induced c-Fos: Stimulation of nucleotide excision repair and protection against sustained JNK activation and apoptosis. Carcinogenesis. 2007;28:183-90 pubmed
    ..The data support the hypothesis that non-repaired DNA damage is the cause for the late and sustained activation of the MAP kinase pathway in response to genotoxins. ..
  15. Kaina B, Christmann M, Naumann S, Roos W. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst). 2007;6:1079-99 pubmed
    ..Modulation of MGMT expression in tumors and normal tissue is currently being investigated as a possible strategy for improving cancer therapy. ..
  16. Bayram Ö, Biesemann C, Krappmann S, Galland P, Braus G. More than a repair enzyme: Aspergillus nidulans photolyase-like CryA is a regulator of sexual development. Mol Biol Cell. 2008;19:3254-62 pubmed publisher
    ..This represents a paradigm for the evolutionary transition between photolyases and cryptochromes. ..
  17. Greubel C, Hable V, Drexler G, Hauptner A, Dietzel S, Strickfaden H, et al. Quantitative analysis of DNA-damage response factors after sequential ion microirradiation. Radiat Environ Biophys. 2008;47:415-22 pubmed publisher
    ..Here, we describe the quantitative evaluation of immunofluorescence intensities after sequential irradiation. ..
  18. Korfei M, Schmitt S, Ruppert C, Henneke I, Markart P, Loeh B, et al. Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs. J Proteome Res. 2011;10:2185-205 pubmed publisher
    ..In summary, our results indicate that IPF is characterized by epithelial cell injury, apoptosis, and aberrant epithelial proliferation. ..
  19. Dunkern T, Roos W, Kaina B. Apoptosis induced by MNNG in human TK6 lymphoblastoid cells is p53 and Fas/CD95/Apo-1 related. Mutat Res. 2003;544:167-72 pubmed
    ..This is in contrast to CHO fibroblasts in which, in response to O(6)MeG, the mitochondrial damage pathway becomes activated. ..
  20. Hauptner A, Dietzel S, Drexler G, Reichart P, Krücken R, Cremer T, et al. Microirradiation of cells with energetic heavy ions. Radiat Environ Biophys. 2004;42:237-45 pubmed
    ..In spite of single ion irradiation, we frequently observed split fluorescence foci which might be explained by small-scale chromatin movements. ..
  21. Hoffmann S, Spitkovsky D, Radicella J, Epe B, Wiesner R. Reactive oxygen species derived from the mitochondrial respiratory chain are not responsible for the basal levels of oxidative base modifications observed in nuclear DNA of Mammalian cells. Free Radic Biol Med. 2004;36:765-73 pubmed
    ..This was also true for glutathione-depleted cells. The results indicate that the contribution of mitochondria to the endogenously generated background levels of oxidative damage in the nuclear DNA is negligible. ..
  22. Chen S, Davies A, Sagan D, Ulrich H. The RING finger ATPase Rad5p of Saccharomyces cerevisiae contributes to DNA double-strand break repair in a ubiquitin-independent manner. Nucleic Acids Res. 2005;33:5878-86 pubmed
  23. Bakhiya N, Stephani M, Bahn A, Ugele B, Seidel A, Burckhardt G, et al. Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters. J Am Soc Nephrol. 2006;17:1414-21 pubmed
    ..This study indicates that OAT can mediate the basolateral uptake of reactive sulfuric acid esters into proximal tubule cells and thereby participate in kidney cell damage by these compounds. ..
  24. Alt A, Lammens K, Chiocchini C, Lammens A, Pieck J, Kuch D, et al. Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta. Science. 2007;318:967-70 pubmed
    ..Our analysis reveals the set of structural features that enable Pol eta to replicate across strongly distorting DNA lesions. ..
  25. Brandt A, Krohne G, Grosshans J. The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies. Aging Cell. 2008;7:541-51 pubmed publisher
    ..We conclude that lobulation of the nuclear membrane induced by the insertion of farnesylated lamina-proteins can lead to aging-like phenotypes. ..
  26. Greubel C, Hable V, Drexler G, Hauptner A, Dietzel S, Strickfaden H, et al. Competition effect in DNA damage response. Radiat Environ Biophys. 2008;47:423-9 pubmed publisher
    ..The observed effects suggest that DNA damage response at individual nuclear sites depends on the time course of damage load. This may have implications for therapeutic radiation treatments. ..
  27. Tobias F, Durante M, Taucher Scholz G, Jakob B. Spatiotemporal analysis of DNA repair using charged particle radiation. Mutat Res. 2010;704:54-60 pubmed publisher
    ..With the help of the microbeam, geometrical patterns of traversing ions can be applied facilitating the analysis of spatial organisation of repair. ..
  28. Verbruggen P, Ruf M, Blakqori G, Overby A, Heidemann M, Eick D, et al. Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II. J Biol Chem. 2011;286:3681-92 pubmed publisher
  29. Nilsson S, Huelsenbeck J, Fritz G. Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. Cancer Lett. 2011;304:60-9 pubmed publisher
    ..In this regard, lovastatin and metformin turned out as the most effective inhibitory drugs. The data show that MP inhibitors can affect the anti-tumor efficacy of anticancer drugs and impact the DDR of human sarcoma cells. ..
  30. Poehlmann A, Kuester D, Malfertheiner P, Guenther T, Roessner A. Inflammation and Barrett's carcinogenesis. Pathol Res Pract. 2012;208:269-80 pubmed publisher
    ..We highlight the role of oxidative stress and deregulated DNA damage checkpoints besides the NF?B pathway. ..
  31. Hable V, Drexler G, Brüning T, Burgdorf C, Greubel C, Derer A, et al. Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity. PLoS ONE. 2012;7:e41943 pubmed publisher
    ..So this work shows that damage quality has a large influence on repair processes and has to be considered when comparing different studies. ..
  32. Boxhammer V, Li Y, Köritzer J, Shimizu T, Maisch T, Thomas H, et al. Investigation of the mutagenic potential of cold atmospheric plasma at bactericidal dosages. Mutat Res. 2013;753:23-8 pubmed publisher
    ..The results show that a CAP treatment of up to 240 s and repeated treatments of 30s every 12h did not induce mutagenicity at the Hprt locus beyond naturally occurring spontaneous mutations. ..
  33. Khobta A, Epe B. Repair of oxidatively generated DNA damage in Cockayne syndrome. Mech Ageing Dev. 2013;134:253-60 pubmed publisher
    ..g. in the mitochondrial response to oxidatively generated DNA damage and in the maintenance of gene transcription. ..
  34. Schlereth K, Heyl C, Krampitz A, Mernberger M, Finkernagel F, Scharfe M, et al. Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions. PLoS Genet. 2013;9:e1003726 pubmed publisher
  35. Karg E, Smets M, Ryan J, Forne I, Qin W, Mulholland C, et al. Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells. J Mol Biol. 2017;429:3814-3824 pubmed publisher
    ..In summary, we identified novel ubiquitination targets that link UHRF1 to transcriptional regulation and DNA damage response. ..
  36. Gillardon F, Wickert H, Zimmermann M. Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain. Neurosci Lett. 1995;192:85-8 pubmed
  37. Schreier W, Schrader T, Koller F, Gilch P, Crespo Hernandez C, Swaminathan V, et al. Thymine dimerization in DNA is an ultrafast photoreaction. Science. 2007;315:625-9 pubmed
    ..The low quantum yield of this photoreaction is proposed to result from infrequent conformational states in the unexcited polymer, revealing a strong link between conformation before light absorption and photodamage. ..
  38. Rohnstock A, Lehmann L. Evaluation of the probe dihydrocalcein acetoxymethylester as an indicator of reactive oxygen species formation and comparison with oxidative DNA base modification determined by modified alkaline elution technique. Toxicol In Vitro. 2007;21:1552-62 pubmed
    ..In conclusion, though intracellular oxidation of dihydrocalcein represents a fast screening method, it detects a limited spectrum of ROS. ..
  39. Díaz Carballo D, Malak S, Bardenheuer W, Freistuehler M, Peter Reusch H. The contribution of plukenetione A to the anti-tumoral activity of Cuban propolis. Bioorg Med Chem. 2008;16:9635-43 pubmed publisher
    ..We assume that plukenetione A contributes to the anti-tumoral effect of Cuban propolis mainly by targeting topoisomerase I as well as DNA polymerase. ..
  40. Schwerdtle T, Ebert F, Thuy C, Richter C, Mullenders L, Hartwig A. Genotoxicity of soluble and particulate cadmium compounds: impact on oxidative DNA damage and nucleotide excision repair. Chem Res Toxicol. 2010;23:432-42 pubmed publisher
    ..These data reveal new insights into the mechanisms involved in cadmium carcinogenesis and provide further evidence that DNA repair inhibition may be one predominant mechanism in cadmium induced carcinogenicity...
  41. Karras G, Jentsch S. The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase. Cell. 2010;141:255-67 pubmed publisher
    ..We therefore propose that the RAD6 pathway acts on single-stranded gaps left behind newly restarted replication forks. ..
  42. Obeid S, Welte W, Diederichs K, Marx A. Amino acid templating mechanisms in selection of nucleotides opposite abasic sites by a family a DNA polymerase. J Biol Chem. 2012;287:14099-108 pubmed publisher
    ..The nucleotide was often used in studying stacking effects in DNA polymerization. Here, no interaction with Tyr-761 as found for the natural nucleotides is observed, indicating a different reaction path for this non-natural nucleotide. ..
  43. Krifka S, Spagnuolo G, Schmalz G, Schweikl H. A review of adaptive mechanisms in cell responses towards oxidative stress caused by dental resin monomers. Biomaterials. 2013;34:4555-63 pubmed publisher
  44. Helmig S, Dopp E, Wenzel S, Walter D, Schneider J. Induction of altered mRNA expression profiles caused by fibrous and granular dust. Mol Med Rep. 2014;9:217-28 pubmed publisher
    ..PCR arrays, therefore, may be a helpful tool to estimate the hazard risk of new materials. ..
  45. Epe B, Ballmaier D, Roussyn I, Briviba K, Sies H. DNA damage by peroxynitrite characterized with DNA repair enzymes. Nucleic Acids Res. 1996;24:4105-10 pubmed
  46. Korabiowska M, Betke H, Kellner S, Stachura J, Schauer A. Differential expression of growth arrest, DNA damage genes and tumour suppressor gene p53 in naevi and malignant melanomas. Anticancer Res. 1997;17:3697-700 pubmed
    ..Prognostic significance for GADD 34 was not found. Our conclusion is that GADD proteins play an important role in the malignant transformation of naevus to melanoma and GADD 45 and GADD 153 proteins can influence patient survival. ..
  47. Adam W, Arnold M, Grimm G, Saha Möller C, Dall Acqua F, Miolo G, et al. 4-tert-butylperoxymethyl-9-methoxypsoralen as intercalating photochemical alkoxyl-radical source for oxidative DNA damage. Photochem Photobiol. 1998;68:511-8 pubmed
    ..With calf thymus DNA, 8-oxoGua and small amounts of guanidine-releasing products, e.g. oxazolone, were observed. However, in these reactions the photoproduct also displayed some DNA-oxidizing capacity. ..
  48. Niewolik D, Pannicke U, Lu H, Ma Y, Wang L, Kulesza P, et al. DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs. J Biol Chem. 2006;281:33900-9 pubmed
    ..Second, DNA-PKcs may optimally configure 5' and 3' overhang substrates for the endonucleolytic function of Artemis. ..
  49. Rössler U, Hornhardt S, Seidl C, Müller Laue E, Walsh L, Panzer W, et al. The sensitivity of the alkaline comet assay in detecting DNA lesions induced by X rays, gamma rays and alpha particles. Radiat Prot Dosimetry. 2006;122:154-9 pubmed
    ..02 Gy for Am-241 and depicte a higher biological effectiveness. These results indicate that differences in biological effects arise through downstream processing of complex DNA damage. ..
  50. Tarasov V, Jung P, Verdoodt B, Lodygin D, Epanchintsev A, Menssen A, et al. Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle. 2007;6:1586-93 pubmed
    ..siRNAs corresponding to p53-induced miRNAs may have potential as cancer therapeutic agents as RNA interference based therapies are currently emerging. ..
  51. Klassen R, Krampe S, Meinhardt F. Homologous recombination and the yKu70/80 complex exert opposite roles in resistance against the killer toxin from Pichia acaciae. DNA Repair (Amst). 2007;6:1864-75 pubmed
  52. Jung P, Menssen A, Mayr D, Hermeking H. AP4 encodes a c-MYC-inducible repressor of p21. Proc Natl Acad Sci U S A. 2008;105:15046-51 pubmed publisher
    ..Notably, AP4 is specifically expressed in colonic progenitor and colorectal carcinoma cells. In conclusion, our results indicate that c-MYC employs AP4 to maintain cells in a proliferative, progenitor-like state. ..
  53. Majora M, Wittkampf T, Schuermann B, Schneider M, Franke S, Grether Beck S, et al. Functional consequences of mitochondrial DNA deletions in human skin fibroblasts: increased contractile strength in collagen lattices is due to oxidative stress-induced lysyl oxidase activity. Am J Pathol. 2009;175:1019-29 pubmed publisher
    ..Accordingly, increased LOX expression was also observed in vivo in photoaged human and mouse skin. Therefore, mtDNA deletions in human fibroblasts may lead to functional and structural alterations of the skin. ..
  54. Schmutzler S, Bachmann L, Fuhrmann H, Schumann J. PUFA-dependent alteration of oxidative parameters of a canine mastocytoma cell line. Acta Vet Hung. 2010;58:453-64 pubmed publisher
    ..Distinct differences between the PUFAs tested underline the impact of the unsaturation degree of fatty acids as well as the position of double bonds on mast cells...
  55. Kellner N, Heimel K, Obhof T, Finkernagel F, Kämper J. The SPF27 homologue Num1 connects splicing and kinesin 1-dependent cytoplasmic trafficking in Ustilago maydis. PLoS Genet. 2014;10:e1004046 pubmed publisher
    ..As the num1 deletion also affects cytoplasmic mRNA transport, the protein may constitute a novel functional interconnection between the two disparate processes of splicing and trafficking. ..
  56. Ramachandran S, Tran D, Klebba Faerber S, Kardinal C, Whetton A, Tamura T. An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. RNA. 2011;17:1957-66 pubmed publisher
    ..Furthermore, the treatment with KU55933 blocked DNA damage-induced THOC5mRNP complex dissociation, indicating that activation of ATM kinase suppresses the ability of THOC5 to bind to its target mRNAs. ..
  57. Hovest M, Krieg T, Herrmann G. Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence. Exp Dermatol. 2011;20:883-9 pubmed publisher
    ..In conclusion, Chk1 and FANCD2 function downstream of ATR in a non-redundant manner for the establishment and maintenance of psoralen photoactivation-induced senescence. ..
  58. Ji P, Baumer N, Yin T, Diederichs S, Zhang F, Beger C, et al. DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells. Int J Cancer. 2007;121:706-13 pubmed
    ..Taken together, these analyses demonstrate that cyclin A1 exerts antiapoptotic functions by interacting with retinoblastoma and Ku proteins in leukemia cells. ..
  59. Beyerle A, Long A, White P, Kissel T, Stoeger T. Poly(ethylene imine) nanocarriers do not induce mutations nor oxidative DNA damage in vitro in MutaMouse FE1 cells. Mol Pharm. 2011;8:976-81 pubmed publisher
    ..We suggest that the lack of any detectable mutagenic/genotoxic activity of the PEI-based polymers studied here is a crucial step toward a safe use of such nanocarriers in clinical trials. ..
  60. Ahmed E, Agay D, Schrock G, Drouet M, Meineke V, Scherthan H. Persistent DNA damage after high dose in vivo gamma exposure of minipig skin. PLoS ONE. 2012;7:e39521 pubmed publisher
    ..An elevated frequency of keratinocytes with persistent RIFs may thus serve as indicator of previous acute radiation exposure, which may be useful in the follow up of nuclear or radiological accident scenarios. ..
  61. Sriramachandran A, Dohmen R. SUMO-targeted ubiquitin ligases. Biochim Biophys Acta. 2014;1843:75-85 pubmed publisher
    ..This article is part of a Special Issue entitled: Ubiquitin-Proteasome System. Guest Editors: Thomas Sommer and Dieter H. Wolf. ..
  62. Bonfiglio J, Colby T, Matic I. Mass spectrometry for serine ADP-ribosylation? Think o-glycosylation!. Nucleic Acids Res. 2017;45:6259-6264 pubmed publisher
  63. Hintzsche H, Polat B, Schewe V, Djuzenova C, Pfreundner L, Flentje M, et al. Micronucleus formation kinetics in buccal mucosa cells of head and neck cancer patients undergoing radiotherapy. Toxicol Lett. 2012;212:33-7 pubmed publisher
    ..No difference was observed between radiation-only patients and patients receiving additional chemotherapy. Age, gender, and tumor stage did not have an influence on the MN formation kinetics...
  64. Rose J, Soder S, Skhirtladze C, Schmitz N, Gebhard P, Sesselmann S, et al. DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes. Osteoarthritis Cartilage. 2012;20:1020-8 pubmed publisher
    ..This promotes increased malfunctioning of the cells and finally the loss of their capacity to keep up cell and tissue homeostasis, i.e., prevent OA. ..
  65. Gándara C, de Lucena D, Torres R, Serrano E, Altenburger S, Graumann P, et al. Activity and in vivo dynamics of Bacillus subtilis DisA are affected by RadA/Sms and by Holliday junction-processing proteins. DNA Repair (Amst). 2017;55:17-30 pubmed publisher
    ..RadA/Sms may be involved in modulating DisA activities. ..
  66. Ochs K, Sobol R, Wilson S, Kaina B. Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage. Cancer Res. 1999;59:1544-51 pubmed
  67. Sturm I, Bosanquet A, Hermann S, Guner D, Dorken B, Daniel P. Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy. Cell Death Differ. 2003;10:477-84 pubmed
    ..This finding may explain at least to some extent the development of resistance to second-line anticancer chemotherapy. ..
  68. Heitzeberg F, Chen I, Hartung F, Orel N, Angelis K, Puchta H. The Rad17 homologue of Arabidopsis is involved in the regulation of DNA damage repair and homologous recombination. Plant J. 2004;38:954-68 pubmed
    ..Our results indicate that a mutant Rad17 pathway is associated with a general deregulation of DNA repair, which seems to be correlated with a deficiency in non-homologous DSB repair. ..
  69. Efferth T. Microarray-based prediction of cytotoxicity of tumor cells to cantharidin. Oncol Rep. 2005;13:459-63 pubmed
    ..The present investigation represents a starting point to dissect the genes and molecular pathways responsible for cellular response to cantharidin in more detail. ..
  70. Roos W, Christmann M, Fraser S, Kaina B. Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair. Cell Death Differ. 2007;14:1422-32 pubmed
    ..The high apoptotic response of ES cells to O(6)-methylguanine adducts may contribute to reduction of the mutational load in the progenitor population. ..
  71. Popov N, Herold S, Llamazares M, Schülein C, Eilers M. Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. Cell Cycle. 2007;6:2327-31 pubmed
    ..Our data extend previous observations that link Myc function to the cellular response to DNA damage. ..
  72. Mortusewicz O, Leonhardt H. XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions. BMC Mol Biol. 2007;8:81 pubmed
    ..These results show that PCNA and XRCC1 have distinct kinetic properties with functional consequences for their capacity to respond to successive DNA damage events. ..
  73. Gatz S, Keimling M, Baumann C, Dork T, Debatin K, Fulda S, et al. Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner. Carcinogenesis. 2008;29:519-27 pubmed publisher
    ..Repression of error-prone recombination subpathways could at least partially explain the chemopreventive effects of this natural plant constituent in animal cancer models. ..
  74. Singh P, Marikkannu R, Bitomsky N, Klempnauer K. Disruption of the Pdcd4 tumor suppressor gene in chicken DT40 cells reveals its role in the DNA-damage response. Oncogene. 2009;28:3758-64 pubmed publisher
    ..Low Pdcd4 expression, which is frequently observed in tumor cells, might therefore contribute to tumorigenesis by disturbing the cellular DNA-damage response. ..
  75. Hassan M, Feyen O, Grinstein E. Fas-induced apoptosis of renal cell carcinoma is mediated by apoptosis signal-regulating kinase 1 via mitochondrial damage-dependent caspase-8 activation. Cell Oncol. 2009;31:437-56 pubmed publisher
    ..Thus, the described molecular mechanisms of CH11-induced apoptosis suggest the reliability of Fas activation as an alternative therapeutic approach for the treatment of patients with advanced renal cell carcinoma. ..
  76. Toulany M, Kehlbach R, Rodemann H, Mozdarani H. Radiocontrast media affect radiation-induced DNA damage repair in vitro and in vivo by affecting Akt signalling. Radiother Oncol. 2010;94:110-6 pubmed publisher
    ..Iohexol only blocked phosphorylation of Akt and DNA-PKcs at S2056. RCM result in clastogenic effects through interference intracellular signalling cascades involved in the regulation of non-homologous end-joining repair of DNA-DSB. ..
  77. Hackenberg S, Zimmermann F, Scherzed A, Friehs G, Froelich K, Ginzkey C, et al. Repetitive exposure to zinc oxide nanoparticles induces dna damage in human nasal mucosa mini organ cultures. Environ Mol Mutagen. 2011;52:582-9 pubmed publisher
    ..Thus, our results suggest that repetitive exposure to low concentrations of ZnO-NPs results in persistent or ongoing DNA damage...
  78. Karras G, Fumasoni M, Sienski G, Vanoli F, Branzei D, Jentsch S. Noncanonical role of the 9-1-1 clamp in the error-free DNA damage tolerance pathway. Mol Cell. 2013;49:536-46 pubmed publisher
    ..Our findings thus reveal unexpected cooperation in the error-free pathway between the two related clamps and indicate that 9-1-1 plays a broader role in the DNA damage response than previously assumed. ..
  79. Wenig U, Meyer S, Stadler R, Fischer S, Werner D, Lauter A, et al. Identification of MAIN, a factor involved in genome stability in the meristems of Arabidopsis thaliana. Plant J. 2013;75:469-83 pubmed publisher
  80. Grosheva A, Zharkov D, Stahl J, Gopanenko A, Tupikin A, Kabilov M, et al. Recognition but no repair of abasic site in single-stranded DNA by human ribosomal uS3 protein residing within intact 40S subunit. Nucleic Acids Res. 2017;45:3833-3843 pubmed publisher
  81. Hendriks C, Hartkamp J, Wiezorek S, Steinkamp A, Rossetti G, Luscher B, et al. Sulfoximines as ATR inhibitors: Analogs of VE-821. Bioorg Med Chem Lett. 2017;27:2659-2662 pubmed publisher
    ..Together our findings suggest that the sulfilimidoyl- and sulfoximidoyl-substituted analogs are efficient ATR inhibitors. ..
  82. Lankenau S, Burkle A, Lankenau D. Detection of poly(ADP-ribose) synthesis in Drosophila testes upon gamma-irradiation. Chromosoma. 1999;108:44-51 pubmed
    ..In primary spermatocytes pADPr is associated with three loci corresponding to the chromosomes at the nuclear periphery. ..
  83. Roos W, Baumgartner M, Kaina B. Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1. Oncogene. 2004;23:359-67 pubmed
  84. Subramaniam S, Zirrgiebel U, Von Bohlen Und Halbach O, Strelau J, Laliberte C, Kaplan D, et al. ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3. J Cell Biol. 2004;165:357-69 pubmed
    ..Antioxidants that reduced ERK activation and PM damage showed no effect on caspase-3 activation or DNA damage. These data identify ERK as an important executor of neuronal damage involving a caspase-3-independent mechanism. ..
  85. Mees A, Klar T, Gnau P, Hennecke U, Eker A, Carell T, et al. Crystal structure of a photolyase bound to a CPD-like DNA lesion after in situ repair. Science. 2004;306:1789-93 pubmed
  86. Lodygin D, Hermeking H. The role of epigenetic inactivation of 14-3-3sigma in human cancer. Cell Res. 2005;15:237-46 pubmed
  87. Bhonde M, Hanski M, Notter M, Gillissen B, Daniel P, Zeitz M, et al. Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth. Oncogene. 2006;25:165-75 pubmed
    ..In conclusion, cell cycle arrest as well as apoptosis may be equipotent mechanisms mediating the chemotherapeutic effects of irinotecan. ..
  88. Nemajerova A, Mena P, Fingerle Rowson G, Moll U, Petrenko O. Impaired DNA damage checkpoint response in MIF-deficient mice. EMBO J. 2007;26:987-97 pubmed
    ..Given that CSN plays a central role in the assembly of SCF complexes in vivo, regulation of Jab1/CSN5 by MIF is required to sustain optimal composition and function of the SCF complex. ..
  89. Briggs A, Stenzel U, Johnson P, Green R, Kelso J, Prüfer K, et al. Patterns of damage in genomic DNA sequences from a Neandertal. Proc Natl Acad Sci U S A. 2007;104:14616-21 pubmed
    ..The results suggest that reliable genome sequences can be obtained from Pleistocene organisms. ..
  90. Waltes R, Kalb R, Gatei M, Kijas A, Stumm M, Sobeck A, et al. Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder. Am J Hum Genet. 2009;84:605-16 pubmed publisher
    ..In conclusion, we have identified and characterized a patient with a RAD50 deficiency that results in a clinical phenotype that can be classified as an NBS-like disorder (NBSLD). ..
  91. Schorr S, Schneider S, Lammens K, Hopfner K, Carell T. Mechanism of replication blocking and bypass of Y-family polymerase {eta} by bulky acetylaminofluorene DNA adducts. Proc Natl Acad Sci U S A. 2010;107:20720-5 pubmed publisher
    ..In our model, TLS is accomplished without rotation of the lesion into the anti conformation as previously thought. ..
  92. Dittmann K, Mayer C, Fehrenbacher B, Schaller M, Kehlbach R, Rodemann H. Nuclear epidermal growth factor receptor modulates cellular radio-sensitivity by regulation of chromatin access. Radiother Oncol. 2011;99:317-22 pubmed publisher
    ..Thus interventional EGFR strategies during tumor treatment may also interact with DNA-repair by blocking access to damaged DNA. ..