Genomes and Genes
Experts and Doctors on dna binding proteins in United States
Locale: United States
Topic: dna binding proteins
Publications362 found, 100 shown here
- Maciejewski M, Liu D, Prasad R, Wilson S, Mullen G. Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity. J Mol Biol. 2000;296:229-53 pubmed..H34, which apparently participates in detection of the abasic site hole and assists in the opening of the hemiacetal, shows conformational exchange. ..
- Phippen T, Sweigart A, Moniwa M, Krumm A, Davie J, Parkhurst S. Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression. J Biol Chem. 2000;275:37628-37 pubmed..Hairy defines a new class of proteins that requires both CtBP and Groucho co-factors for proper function. ..
- Ying Y, Zhao G. Detection of multiple bone morphogenetic protein messenger ribonucleic acids and their signal transducer, Smad1, during mouse decidualization. Biol Reprod. 2000;63:1781-6 pubmed..The Bmp2 signals were primarily detected in decidual cells, whereas Bmp4 and Smad1 transcripts were mainly detected in vascular endothelial cells, suggesting that they may be involved in decidual angiogenesis. ..
- Queva C, McArthur G, Iritani B, Eisenman R. Targeted deletion of the S-phase-specific Myc antagonist Mad3 sensitizes neuronal and lymphoid cells to radiation-induced apoptosis. Mol Cell Biol. 2001;21:703-12 pubmed..However, upon gamma irradiation, increased cell death of thymocytes and neural progenitor cells was observed, implicating mad3 in the regulation of the cellular response to DNA damage. ..
- Peters K, Smith H, Stark G, Sen G. IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA. Proc Natl Acad Sci U S A. 2002;99:6322-7 pubmed..Therefore, IRF-3 activation by dsRNA is sufficient to induce the transcription of genes with simple promoters such as 561 as well as complex promoters such as IFN-beta. ..
- Mellon I, Hock T, Reid R, Porter P, States J. Polymorphisms in the human xeroderma pigmentosum group A gene and their impact on cell survival and nucleotide excision repair. DNA Repair (Amst). 2002;1:531-46 pubmed..Hence, the XPA gene appears to be a cold spot for genetic variation and rare polymorphisms in the coding region of the gene do not reduce NER or cell survival after UV irradiation. ..
- Kalyuzhnaya M, Lidstrom M. QscR, a LysR-type transcriptional regulator and CbbR homolog, is involved in regulation of the serine cycle genes in Methylobacterium extorquens AM1. J Bacteriol. 2003;185:1229-35 pubmed..We conclude that QscR acts as a positive transcriptional regulator of most of the serine cycle enzymes and also as an autorepressor...
- Cousins R, Blanchard R, Popp M, Liu L, Cao J, Moore J, et al. A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells. Proc Natl Acad Sci U S A. 2003;100:6952-7 pubmed..Categorization by function revealed numerous genes needed for host defense were among those identified as zinc responsive, including cytokine receptors and genes associated with amplification of the Th1 immune response. ..
- Jiang H, Daniels P, Andrews G. Putative zinc-sensing zinc fingers of metal-response element-binding transcription factor-1 stabilize a metal-dependent chromatin complex on the endogenous metallothionein-I promoter. J Biol Chem. 2003;278:30394-402 pubmed..During the course of these studies, it was discovered that mouse MTF-1 is polymorphic. The impact of these polymorphisms on MTF-1 metalloregulatory functions is discussed. ..
- Abbott A. Heterochronic genes. Curr Biol. 2003;13:R824-5 pubmed
- Kruzynska Frejtag A, Wang J, Maeda M, Rogers R, Krug E, Hoffman S, et al. Periostin is expressed within the developing teeth at the sites of epithelial-mesenchymal interaction. Dev Dyn. 2004;229:857-68 pubmed
- Myzak M, Karplus P, Chung F, Dashwood R. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res. 2004;64:5767-74 pubmed..Collectively, these findings suggest that SFN may be effective as a tumor-suppressing agent and as a chemotherapeutic agent, alone or in combination with other HDAC inhibitors currently undergoing clinical trials. ..
- Sampath H, Ntambi J. Polyunsaturated fatty acid regulation of gene expression. Nutr Rev. 2004;62:333-9 pubmed..The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-alpha, HNF-4alpha, and LXRalpha in mediating the nuclear effects of PUFAs are addressed. ..
- Zhou H, Lutkenhaus J. MinC mutants deficient in MinD- and DicB-mediated cell division inhibition due to loss of interaction with MinD, DicB, or a septal component. J Bacteriol. 2005;187:2846-57 pubmed..These mutations differentiate the interactions of MinC with its partners and further support the model of MinCD- and MinC-DicB-mediated cell division inhibition. ..
- Boulé J, Vega L, Zakian V. The yeast Pif1p helicase removes telomerase from telomeric DNA. Nature. 2005;438:57-61 pubmed..We propose that Pif1p helicase activity limits telomerase action both in vivo and in vitro by displacing active telomerase from DNA ends. ..
- Foster K, McCrary W, Ross J, Wright C. Members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt. Oncogene. 2006;25:4605-12 pubmed..These data provide the first evidence that Akt signaling may modulate function of the hSWI/SNF complex. ..
- Sun X, Song Q. PKC-mediated USP phosphorylation is required for 20E-induced gene expression in the salivary glands of Drosophila melanogaster. Arch Insect Biochem Physiol. 2006;62:116-27 pubmed..The composite data suggest that PKC-mediated USP phosphorylation is required for 20E-induced gene expression in the salivary glands of Drosophila melanogaster. ..
- Ramsey J, Daugherty M, Kelm R. Hydrodynamic studies on the quaternary structure of recombinant mouse Purbeta. J Biol Chem. 2007;282:1552-60 pubmed..Sedimentation equilibrium analyses confirmed that Purbeta self-associates in a reversible monomer-dimer equilibrium characterized by a K(d) = 1.13 +/- 0.27 microm. ..
- Skaggs H, Xing H, Wilkerson D, Murphy L, Hong Y, Mayhew C, et al. HSF1-TPR interaction facilitates export of stress-induced HSP70 mRNA. J Biol Chem. 2007;282:33902-7 pubmed
- Grozav A, Chikamori K, Kozuki T, Grabowski D, Bukowski R, Willard B, et al. Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity. Nucleic Acids Res. 2009;37:382-92 pubmed publisher..These results provide strong support for an essential role of CKIdelta/epsilon in phosphorylating Ser-1106 in human topo IIalpha and in regulating enzyme function. ..
- Zhang Z, Verheyden J, Hassell J, Sun X. FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell. 2009;16:607-13 pubmed publisher..This finding elucidates a novel aspect of the mechanism coordinating limb development along the A-P and P-D axes...
- Thorpe J, Schwarze S. IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1. Cell Stress Chaperones. 2010;15:497-508 pubmed publisher..We conclude that IRE1alpha activity controls a subset of the ER stress response and mediates proliferation through tight control of Xbp-1 splicing. ..
- Gonzalez B, Michel F, Simmen R. A regulatory element within the uteroferrin gene 5'-flanking region binds a pregnancy-associated uterine endometrial protein. DNA Cell Biol. 1994;13:365-76 pubmed..7-8.6) and is present in pig endometrium throughout pregnancy. The functional relevance of this DNA-binding protein in the control of UF gene transcription in the endometrium is discussed. ..
- Lynch J, Lala D, Peluso J, Luo W, Parker K, White B. Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues. Mol Endocrinol. 1993;7:776-86 pubmed..Collectively, these studies implicate SF-1 in the regulation of steroid hydroxylase gene expression in nonadrenal tissues, significantly extending previous studies in adrenocortical cells. ..
- Li X, Leung S, Qureshi S, Darnell J, Stark G. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J Biol Chem. 1996;271:5790-4 pubmed..Deletion analysis reveals that the C-terminal domain of STAT2 is important for transcriptional activation mediated by both STAT1-STAT2 heterodimers and ISGF3. ..
- Roberts S, Miller S, Lane W, Lee S, Hahn S. Cloning and functional characterization of the gene encoding the TFIIIB90 subunit of RNA polymerase III transcription factor TFIIIB. J Biol Chem. 1996;271:14903-9 pubmed..Our results suggest that the binding sites for BRF1 and TFIIIB90 on TBP-DNA both overlap the binding sites for TFIIA and TFIIB. ..
- Khoroshilova N, Popescu C, Munck E, Beinert H, Kiley P. Iron-sulfur cluster disassembly in the FNR protein of Escherichia coli by O2: [4Fe-4S] to [2Fe-2S] conversion with loss of biological activity. Proc Natl Acad Sci U S A. 1997;94:6087-92 pubmed..It has yet to be determined whether the form of FNR containing the [2Fe-2S]2+ cluster has any biological significance, e.g., as an in vivo intermediate that is more rapidly converted to the active form than the apoprotein. ..
- Queva C, Hurlin P, Foley K, Eisenman R. Sequential expression of the MAD family of transcriptional repressors during differentiation and development. Oncogene. 1998;16:967-77 pubmed..Taken together, our data suggest that the different members of the MAD protein family exert their functions at distinct steps during the transition between proliferation and differentiation. ..
- Peekhaus N, Conway T. Positive and negative transcriptional regulation of the Escherichia coli gluconate regulon gene gntT by GntR and the cyclic AMP (cAMP)-cAMP receptor protein complex. J Bacteriol. 1998;180:1777-85 pubmed..Transcription of gntT is activated by binding of the cyclic AMP (cAMP)-cAMP receptor protein (CRP) complex to a CRP binding site positioned at -71 upstream of the gntT transcription start site. ..
- Zhou Z, Gong Q, Epstein M, January C. HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects. J Biol Chem. 1998;273:21061-6 pubmed..These findings suggest that the loss of HERG channel function in LQT-2 mutations is caused by multiple mechanisms including abnormal channel processing, the generation of nonfunctional channels, and altered channel gating. ..
- Herbelin C, Chirillo S, Melnick K, Whittam T. Gene conservation and loss in the mutS-rpoS genomic region of pathogenic Escherichia coli. J Bacteriol. 2000;182:5381-90 pubmed..Phylogenetic analysis of the common sequences indicates that the long intergenic region is ancestral and at least two separate deletion events gave rise to the shorter regions characteristic of the E. coli O157:H7 and K-12 lineages. ..
- Weber T, Huang Q, Monks T, Lau S. Differential regulation of redox responsive transcription factors by the nephrocarcinogen 2,3,5-Tris(glutathion-S-yl)hydroquinone. Chem Res Toxicol. 2001;14:814-21 pubmed..Although there is a common requirement for hydrogen peroxide (H(2)O(2)) in the regulation of these DNA-binding activities, there appears to be divergent regulation after H(2)O(2) generation in renal epithelial cells. ..
- Maser R, Mirzoeva O, Wells J, Olivares H, Williams B, Zinkel R, et al. Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol Cell Biol. 2001;21:6006-16 pubmed..These data suggest that the Mre11 complex suppresses genomic instability through its influence on both the regulation and progression of DNA replication. ..
- Bala S, Peltomaki P. CYCLIN D1 as a genetic modifier in hereditary nonpolyposis colorectal cancer. Cancer Res. 2001;61:6042-5 pubmed
- Meller V, Rattner B. The roX genes encode redundant male-specific lethal transcripts required for targeting of the MSL complex. EMBO J. 2002;21:1084-91 pubmed..Therefore, the roX1 and roX2 genes produce redundant, male-specific lethal transcripts required for targeting the MSL complex. ..
- Dziema H, Oatis B, Butcher G, Yates R, Hoyt K, Obrietan K. The ERK/MAP kinase pathway couples light to immediate-early gene expression in the suprachiasmatic nucleus. Eur J Neurosci. 2003;17:1617-27 pubmed..MAPK pathway-dependent gene expression in the SCN may result, in part, from stimulation of CRE-dependent transcription. ..
- Bok J, Keller N. LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot Cell. 2004;3:527-35 pubmed
- Bodwell J, Kingsley L, Hamilton J. Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose-response effects are closely correlated with levels of activated GR and require a functional GR DNA bind. Chem Res Toxicol. 2004;17:1064-76 pubmed
- Zeng L, Liao H, Liu Y, Lee T, Zhu M, Wang X, et al. Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J Biol Chem. 2004;279:48801-7 pubmed..Thus, this SREBP-regulated mechanism may control the efflux of cholesterol, which is a newly defined function of SREBP2 in ECs in addition to its role in cholesterol uptake and biosynthesis...
- Xi J, Zhuang Z, Zhang Z, Selzer T, Spiering M, Hammes G, et al. Interaction between the T4 helicase-loading protein (gp59) and the DNA polymerase (gp43): a locking mechanism to delay replication during replisome assembly. Biochemistry. 2005;44:2305-18 pubmed..Thus, continued assembly of the replisome through addition of the primosome components and elements of the lagging-strand holoenzyme can occur without leading-strand DNA replication. ..
- Liu S, Shen T, Huynh L, Klisovic M, Rush L, Ford J, et al. Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. Cancer Res. 2005;65:1277-84 pubmed..These results suggest a novel mechanism for gene silencing mediated by RUNX1/MTG8 and support the combination of HDAC and DNMT inhibitors as a novel therapeutic approach for t(8;21) AML. ..
- Wang S, Engohang Ndong J, Smith I. Structure of the DNA-binding domain of the response regulator PhoP from Mycobacterium tuberculosis. Biochemistry. 2007;46:14751-61 pubmed..Detailed structural analysis and implications with respect to DNA binding are discussed. ..
- Blickwedehl J, Agarwal M, Seong C, Pandita R, Melendy T, Sung P, et al. Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability. Proc Natl Acad Sci U S A. 2008;105:16165-70 pubmed publisher..Together, these data suggest a unique role for PA200 in genomic stability that is likely mediated through its ability to enhance postglutamyl cleavage by proteasomes. ..
- Nash K, Chen W, Salganik M, Muzyczka N. Identification of cellular proteins that interact with the adeno-associated virus rep protein. J Virol. 2009;83:454-69 pubmed publisher..Our study suggests that the interaction of AAV with cellular proteins is much more complex than previously suspected and provides a resource for further studies of the AAV life cycle. ..
- Wu Y, Outten F. IscR controls iron-dependent biofilm formation in Escherichia coli by regulating type I fimbria expression. J Bacteriol. 2009;191:1248-57 pubmed publisher..coli. We propose that iron-dependent regulation of FimE via IscR leads to decreased surface attachment and biofilm dispersal under iron-limiting conditions. ..
- Honma K, Mishima E, Inagaki S, Sharma A. The OxyR homologue in Tannerella forsythia regulates expression of oxidative stress responses and biofilm formation. Microbiology. 2009;155:1912-22 pubmed publisher..forsythia constitutively activates antioxidant genes involved in resistance to peroxides as well as oxygen stress (aerotolerance). In addition, the oxyR deletion attenuates biofilm formation in T. forsythia. ..
- Huang C, Chiribau C, Majumder M, Chiang C, Wek R, Kelm R, et al. A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha). J Biol Chem. 2009;284:32312-20 pubmed publisher..In addition, we propose that genes may use stress-response elements such as the INE to support basal expression in the absence of stress. ..
- Chang C, Kemp P, Molineux I. Gp15 and gp16 cooperate in translocating bacteriophage T7 DNA into the infected cell. Virology. 2010;398:176-86 pubmed publisher..After ejection from the infecting particle, gp15 and gp16 thus function together in ratcheting the leading end of the T7 genome into the cytoplasm of the infected cell...
- McKee A, Gavett B, Stern R, Nowinski C, Cantu R, Kowall N, et al. TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2010;69:918-29 pubmed publisher..This is the first pathological evidence that repetitive head trauma experienced in collision sports might be associated with the development of a motor neuron disease. ..
- von Bülow G, Bram R. NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. Science. 1997;278:138-41 pubmed..TACI-induced activation of NF-AT was specifically blocked by a dominant-negative CAML mutant, thus implicating CAML as a signaling intermediate. ..
- Neves A, Priess J. The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways. Dev Cell. 2005;8:867-79 pubmed..Our results show that the highly divergent REF-1 proteins are nonetheless HES-like bHLH effectors of Notch signaling. ..
- Nguyen Q, Chavli R, Marques J, Conrad P, Wang D, He W, et al. Light controllable siRNAs regulate gene suppression and phenotypes in cells. Biochim Biophys Acta. 2006;1758:394-403 pubmed..This technology should be of interest for phenotypic assays such as cell survival, cell cycle regulation, and cell development. ..
- Kravchenko J, Ilyinskaya G, Komarov P, Agapova L, Kochetkov D, Strom E, et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A. 2008;105:6302-7 pubmed publisher..RETRA is active against tumor cells expressing a variety of p53 mutants and does not affect normal cells. The results validate the mutant p53-p73 complex as a promising and highly specific potential target for cancer therapy. ..
- Ryseck R, Bull P, Takamiya M, Bours V, Siebenlist U, Dobrzanski P, et al. RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. Mol Cell Biol. 1992;12:674-84 pubmed..However, RelB/p50-NF-kappa B heterodimers, in contrast to p50-NF-kappa B homodimers, transactivate transcription of a promoter containing a kappa B-binding site. ..
- Milad M, Sullivan W, Diehl E, Altmann M, Nordeen S, Edwards D, et al. Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A. Mol Endocrinol. 1995;9:838-47 pubmed..Thus, the effects of these immunosuppressant drugs vary with the cell type and hormonal system that is tested. Whether these drug effects relate directly to the immunophilins bound in receptor complexes remains unknown. ..
- Weih F, Carrasco D, Bravo R. Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen. Oncogene. 1994;9:3289-97 pubmed
- Sommer L, Shah N, Rao M, Anderson D. The cellular function of MASH1 in autonomic neurogenesis. Neuron. 1995;15:1245-58 pubmed..Moreover, they suggest that MASH1 does not commit multipotent cells to a neural fate, like its Drosophila achaete-scute counterparts, but rather promotes the differentiation of a committed neuronal precursor. ..
- Gertler F, Niebuhr K, Reinhard M, Wehland J, Soriano P. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996;87:227-39 pubmed..Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility...
- Carver E, Issel Tarver L, Rine J, Olsen A, Stubbs L. Location of mouse and human genes corresponding to conserved canine olfactory receptor gene subfamilies. Mamm Genome. 1998;9:349-54 pubmed..Combined with recently published studies, these data link the four conserved olfactory gene subfamilies to homologous regions of the human, dog, and mouse genomes. ..
- York R, Yao H, Dillon T, Ellig C, Eckert S, McCleskey E, et al. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature. 1998;392:622-6 pubmed..We propose that the activation of Rap1 by C3G represents a common mechanism to induce sustained activation of the MAP kinase cascade in cells that express B-Raf. ..
- Strainic M, Sullivan J, Velevis A, deHaseth P. Promoter recognition by Escherichia coli RNA polymerase: effects of the UP element on open complex formation and promoter clearance. Biochemistry. 1998;37:18074-80 pubmed..Finally, we provide evidence in support of models which describe the DNA melting process accompanying open complex formation as initiating in the -10 promoter region and progressing in the downstream direction. ..
- Kastaniotis A, Mennella T, Konrad C, Torres A, Zitomer R. Roles of transcription factor Mot3 and chromatin in repression of the hypoxic gene ANB1 in yeast. Mol Cell Biol. 2000;20:7088-98 pubmed
- Erickson L, Durell B, Vogel L, O Connor B, Cascalho M, Yasui T, et al. Short-circuiting long-lived humoral immunity by the heightened engagement of CD40. J Clin Invest. 2002;109:613-20 pubmed..These are the first studies to describe the multifaceted function of CD40 in determining the fate of antigen-reactive B cells and provide novel insights into how CD40 agonists can short-circuit humoral immunity. ..
- North T, de Bruijn M, Stacy T, Talebian L, Lind E, Robin C, et al. Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. Immunity. 2002;16:661-72 pubmed..These data provide the first morphological description of embryonic HSCs and contribute new insight into their cellular origin. ..
- Vyas D, Spangenburg E, Abraha T, Childs T, Booth F. GSK-3beta negatively regulates skeletal myotube hypertrophy. Am J Physiol Cell Physiol. 2002;283:C545-51 pubmed..These data suggest that the IGF-I-induced increase in skeletal myotube size is signaled, in part, through the inhibition of GSK-3beta. ..
- Dame C, Sola M, Fandrey J, Rimsza L, Freitag P, Knopfle G, et al. Developmental changes in the expression of transcription factors GATA-1, -2 and -3 during the onset of human medullary haematopoiesis. Br J Haematol. 2002;119:510-5 pubmed
- Wildey G, Patil S, Howe P. Smad3 potentiates transforming growth factor beta (TGFbeta )-induced apoptosis and expression of the BH3-only protein Bim in WEHI 231 B lymphocytes. J Biol Chem. 2003;278:18069-77 pubmed
- Deng W, Liou S, Plunkett G, Mayhew G, Rose D, Burland V, et al. Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18. J Bacteriol. 2003;185:2330-7 pubmed..The two strains exhibit differences in prophages, insertion sequences, and island structures. While CT18 carries two plasmids, one conferring multiple drug resistance, Ty2 has no plasmids and is sensitive to antibiotics. ..
- Shen J, Lao Y, Kamath Loeb A, Wold M, Loeb L. The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity. Mech Ageing Dev. 2003;124:921-30 pubmed..These data should help further elucidation of the molecular mechanisms of genetic instability and premature aging phenotypes manifested by WS. ..
- Gustafson W, Ray S, Jamieson L, Thompson E, Brasier A, Fields A. Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter. J Biol Chem. 2004;279:9400-8 pubmed..Our results indicate that Bcr-Abl-mediated transformation involves transcriptional activation of the PKCiota gene, which in turn is required for Bcr-Abl-mediated chemoresistance. ..
- Ohashi A, Zdzienicka M, Chen J, Couch F. Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. J Biol Chem. 2005;280:14877-83 pubmed..Our results suggest that FANCD2 mediates double strand DNA break repair independently of Rad51-associated homologous recombination. ..
- Jiang Y, Lo W, Akhmametyeva E, Chang L. Over-expression of p73beta results in apoptotic death of post-mitotic hNT neurons. J Neurol Sci. 2006;240:1-6 pubmed..Understanding the regulation of p73 expression will be important for understanding the development of the nervous system and may have implications for the treatment of neurological diseases. ..
- Contakos S, Gaydos C, Pfeil E, McLaughlin K. Subdividing the embryo: a role for Notch signaling during germ layer patterning in Xenopus laevis. Dev Biol. 2005;288:294-307 pubmed
- Staib J, Quindry J, French J, Criswell D, Powers S. Increased temperature, not cardiac load, activates heat shock transcription factor 1 and heat shock protein 72 expression in the heart. Am J Physiol Regul Integr Comp Physiol. 2007;292:R432-9 pubmed..Collectively, these data suggest that HSF1 activation and HSP72 gene transcriptional competence during simulated exercise are linked to elevated heart temperature and are not a direct function of increased cardiac workload. ..
- Lee B, Udagawa T, Singh C, Asano K. Yeast phenotypic assays on translational control. Methods Enzymol. 2007;429:105-37 pubmed..Different amino acid analogs or amino acid enzyme inhibitors are used to study Gcd(-) or Gcn(-) phenotypes. The method of polysome profiling is also described to gain an ultimate "phenotypic" proof for translation defects...
- Wilkerson D, Murphy L, Sarge K. Interaction of HSF1 and HSF2 with the Hspa1b promoter in mouse epididymal spermatozoa. Biol Reprod. 2008;79:283-8 pubmed publisher..These results support a model in which the binding of HSF1, HSF2, and SP1 to the promoter of Hspa1b would allow the rapid formation of a transcription-competent state during the minor ZGA, thereby allowing Hspa1b expression. ..
- Biswas S, Bastia D. Mechanistic insights into replication termination as revealed by investigations of the Reb1-Ter3 complex of Schizosaccharomyces pombe. Mol Cell Biol. 2008;28:6844-57 pubmed publisher..These observations suggest that replication fork arrest is not an intrinsic property of the Reb1-Ter3 complex. ..
- Johnson J, Toft D. Binding of p23 and hsp90 during assembly with the progesterone receptor. Mol Endocrinol. 1995;9:670-8 pubmed..A model is presented to relate these findings to previous models and another complex between hsp90, hsp70, and p60 that appears to be an intermediate in PR assembly. ..
- Keegan K, Holtzman D, Plug A, Christenson E, Brainerd E, Flaggs G, et al. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev. 1996;10:2423-37 pubmed
- Hassan B, Vaessin H. Daughterless is required for the expression of cell cycle genes in peripheral nervous system precursors of Drosophila embryos. Dev Genet. 1997;21:117-22 pubmed..This suggests that all aspects of PNS precursor differentiation examined so far are under the transcriptional control of da. ..
- Singh N, Berger F. Evolution of a mammalian promoter through changes in patterns of transcription factor binding. J Mol Evol. 1998;46:639-48 pubmed..The results are discussed in terms of a model involving a dynamic equilibrium between states of binding site occupancy, the nature of which can be modified during evolution. ..
- Cohen S, Zheng G, Heyman H, Stavnezer E. Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents. Nucleic Acids Res. 1999;27:1006-14 pubmed..This work demonstrates, for the first time, the differences between dimer formation by Ski and SnoN and underscores the importance of dimerization in their activity. ..
- Eberharter A, Sterner D, Schieltz D, Hassan A, Yates J, Berger S, et al. The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae. Mol Cell Biol. 1999;19:6621-31 pubmed..These results indicate that Gcn5, Ada2, and Ada3 function as part of a unique HAT complex (ADA) and represent shared subunits between this complex and SAGA. ..
- Chen Y, McPhie D, Hirschberg J, Neve R. The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. J Biol Chem. 2000;275:8929-35 pubmed..A specific caspase-6 inhibitor blocks this apoptosis. These findings are discussed in the context of abnormalities in the cell cycle that have been observed in Alzheimer's disease. ..
- Wagner S, Hess M, Ormonde Hanson P, Malandro J, Hu H, Chen M, et al. A broad role for the zinc finger protein ZNF202 in human lipid metabolism. J Biol Chem. 2000;275:15685-90 pubmed..Based on the linkage and apparent transcriptional function of ZNF202, we propose that ZNF202 is a candidate susceptibility gene for human dyslipidemia. ..
- Gu J, Elam J, Sartin A, Li W, Roach R, Adair T. Moderate levels of ethanol induce expression of vascular endothelial growth factor and stimulate angiogenesis. Am J Physiol Regul Integr Comp Physiol. 2001;281:R365-72 pubmed..Therefore, the results provide a theoretical basis for speculating that the cardiovascular-protective effects of moderate alcohol consumption may be partly mediated through VEGF-induced angiogenesis...
- Kawanaka H, Tomikawa M, Baatar D, Jones M, Pai R, Szabo I, et al. Despite activation of EGF-receptor-ERK signaling pathway, epithelial proliferation is impaired in portal hypertensive gastric mucosa: relevance of MKP-1, c-fos, c-myc, and cyclin D1 expression. Life Sci. 2001;69:3019-33 pubmed
- Wang X, Kilgore M. Signal cross-talk between estrogen receptor alpha and beta and the peroxisome proliferator-activated receptor gamma1 in MDA-MB-231 and MCF-7 breast cancer cells. Mol Cell Endocrinol. 2002;194:123-33 pubmed..These data suggest that signal cross talk exists bidirectionally between PPARgamma and ER in breast cancer cells. ..
- Jones N, Agani F. Hyperoxia induces Egr-1 expression through activation of extracellular signal-regulated kinase 1/2 pathway. J Cell Physiol. 2003;196:326-33 pubmed..This forms a foundation for analysis of detailed mechanisms underlying Egr-1 activation during hyperoxia and understanding its consequences for regulating cell response to oxygen toxicity. ..