Experts and Doctors on dna binding proteins in United Kingdom

Summary

Locale: United Kingdom
Topic: dna binding proteins

Top Publications

  1. Navaratnam S, Myles G, Strange R, Sancar A. Evidence from extended X-ray absorption fine structure and site-specific mutagenesis for zinc fingers in UvrA protein of Escherichia coli. J Biol Chem. 1989;264:16067-71 pubmed
    ..We thus conclude that the two zinc fingers identified by sequence analysis do indeed have zinc finger structure in UvrA protein. ..
  2. Yamada Y, Warren A, Dobson C, Forster A, Pannell R, Rabbitts T. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc Natl Acad Sci U S A. 1998;95:3890-5 pubmed
    ..Thus, Lmo2 is necessary for early stages of hematopoiesis, and the Lmo2 master gene encodes a protein that has a central and crucial role in the hematopoietic development...
  3. Bishop N, Woodman P. TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes. J Biol Chem. 2001;276:11735-42 pubmed
    ..We conclude that TSG101 and its interacting components are directly involved in endosomal sorting. ..
  4. Corless C, Guiver M, Borrow R, Edwards Jones V, Fox A, Kaczmarski E. Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR. J Clin Microbiol. 2001;39:1553-8 pubmed
    ..The ctrA primer set used in the multiplex PCR was found to be more sensitive (P < 0.0001) than the ctrA primers that had been used for meningococcal PCR testing at that time. ..
  5. Venkitaraman A. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell. 2002;108:171-82 pubmed
    ..Here, I examine what is known about the biological functions of the BRCA proteins and ask how their disruption can induce susceptibility to specific types of cancer. ..
  6. Quinn J, Findlay V, Dawson K, Millar J, Jones N, Morgan B, et al. Distinct regulatory proteins control the graded transcriptional response to increasing H(2)O(2) levels in fission yeast Schizosaccharomyces pombe. Mol Biol Cell. 2002;13:805-16 pubmed
    ..Our results demonstrate that S. pombe uses a combination of stress-responsive regulatory proteins to gauge and effect the appropriate transcriptional response to increasing concentrations of H(2)O(2). ..
  7. Beinke S, Belich M, Ley S. The death domain of NF-kappa B1 p105 is essential for signal-induced p105 proteolysis. J Biol Chem. 2002;277:24162-8 pubmed
    ..Thus, the p105 DD acts as a docking site for IKK, increasing its local concentration in the vicinity of the p105 PEST region and facilitating efficient serine 927 phosphorylation. ..
  8. Rosenblum K, Futter M, Voss K, Erent M, Skehel P, French P, et al. The role of extracellular regulated kinases I/II in late-phase long-term potentiation. J Neurosci. 2002;22:5432-41 pubmed
    ..The ability to visualize the cellular redistribution of ERKII after induction of long-term synaptic plasticity may provide a method for visualizing neuronal circuits underlying information storage in the brain in vivo. ..
  9. Brady N, Gaymes T, Cheung M, Mufti G, Rassool F. Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins. Cancer Res. 2003;63:1798-805 pubmed
    ..These data suggest that the generation of increased constitutive DNA damage may be a common pathway for the creation of NHEJ-dependent genomic instability. ..

More Information

Publications246 found, 100 shown here

  1. Bowen H, Lapham A, Phillips E, Yeung I, Alter Koltunoff M, Levi B, et al. Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1. J Biol Chem. 2003;278:36017-26 pubmed
  2. Milward A, Metherell L, Maamra M, Barahona M, Wilkinson I, Camacho Hubner C, et al. Growth hormone (GH) insensitivity syndrome due to a GH receptor truncated after Box1, resulting in isolated failure of STAT 5 signal transduction. J Clin Endocrinol Metab. 2004;89:1259-66 pubmed
    ..Results are consistent with the hypothesis that the loss of signaling through the Stat5 pathway results in GHIS. ..
  3. Klenova E, Scott A, Roberts J, Shamsuddin S, Lovejoy E, Bergmann S, et al. YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders. J Neurosci. 2004;24:5966-73 pubmed
    ..Our data suggest a novel mechanism that explains, in part, the ability of the distinct VNTR copy numbers to support differential reporter gene expression based on YB-1 binding sites. ..
  4. Grainger D, Overton T, Reppas N, Wade J, Tamai E, Hobman J, et al. Genomic studies with Escherichia coli MelR protein: applications of chromatin immunoprecipitation and microarrays. J Bacteriol. 2004;186:6938-43 pubmed
    ..coli for MelR. This was confirmed by a transcriptomics experiment to analyze RNA in cells either with or without melR. ..
  5. Munarriz E, Barcaroli D, Stephanou A, Townsend P, Maisse C, Terrinoni A, et al. PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. Mol Cell Biol. 2004;24:10593-610 pubmed
    ..These data suggest that PIAS-1, acting partly through binding and sumoylation of p73, is an important component of the cell cycle machinery. ..
  6. Pimanda J, Silberstein L, Dominici M, Dekel B, Bowen M, Oldham S, et al. Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cells. Mol Cell Biol. 2006;26:2615-25 pubmed
  7. García Pedrero J, Kiskinis E, Parker M, Belandia B. The SWI/SNF chromatin remodeling subunit BAF57 is a critical regulator of estrogen receptor function in breast cancer cells. J Biol Chem. 2006;281:22656-64 pubmed
    ..Taken together, our results suggest that targeting BAF57 could represent a new way to effectively inhibit the action of ERalpha. ..
  8. Swales K, Korbonits M, Carpenter R, Walsh D, Warner T, Bishop Bailey D. The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression. Cancer Res. 2006;66:10120-6 pubmed
    ..Our findings show for the first time that FXR is expressed in breast cancer tissue and has multiple properties that could be used for the treatment of breast cancer. ..
  9. McDonald B, Martin Serrano J. Regulation of Tsg101 expression by the steadiness box: a role of Tsg101-associated ligase. Mol Biol Cell. 2008;19:754-63 pubmed
    ..Lastly, we demonstrate that while the C-terminal lysines are targets for polyubiquitination, they are not required for any additional function necessary for ESCRT activity. ..
  10. Keeble A, Khan Z, Forster A, James L. TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved. Proc Natl Acad Sci U S A. 2008;105:6045-50 pubmed publisher
    ..Together, our results reveal that TRIM21 is a previously undescribed type of IgG receptor based on a non-Ig scaffold whose interaction at the fundamental level-structural, thermodynamic, and kinetic-is evolutionarily conserved. ..
  11. Liu F, Walmsley M, Rodaway A, Patient R. Fli1 acts at the top of the transcriptional network driving blood and endothelial development. Curr Biol. 2008;18:1234-40 pubmed publisher
    ..Taken together, these results place Fli1 at the top of the transcriptional regulatory hierarchy for hemangioblast specification in vertebrate embryos. ..
  12. Bencokova Z, Kaufmann M, Pires I, Lecane P, Giaccia A, Hammond E. ATM activation and signaling under hypoxic conditions. Mol Cell Biol. 2009;29:526-37 pubmed publisher
    ..Our findings clearly demonstrate that there are alternate mechanisms for activating ATM that are both stress-specific and independent of the presence of DNA breaks. ..
  13. Cook G, Membrillo Hernandez J, Poole R. Transcriptional regulation of the cydDC operon, encoding a heterodimeric ABC transporter required for assembly of cytochromes c and bd in Escherichia coli K-12: regulation by oxygen and alternative electron acceptors. J Bacteriol. 1997;179:6525-30 pubmed
    ..Aerobic expression was independent of ArcA and Fnr, but induction of cydDC by nitrate and nitrite was dependent on NarL and Fnr...
  14. West S. Processing of recombination intermediates by the RuvABC proteins. Annu Rev Genet. 1997;31:213-44 pubmed
    ..Genetic and biochemical studies indicate that branch migration and resolution are coupled by direct interactions between the three proteins, possibly by the formation of a RuvABC complex. ..
  15. Cullen C, May K, Hagan I, Glover D, Ohkura H. A new genetic method for isolating functionally interacting genes: high plo1(+)-dependent mutants and their suppressors define genes in mitotic and septation pathways in fission yeast. Genetics. 2000;155:1521-34 pubmed
    ..These results demonstrate that screening for high dose-dependent mutants and their suppressors is an effective approach to identify functionally interacting genes. ..
  16. Smith M, Melton L, Ensor E, Packham G, Anderson P, Kinloch R, et al. Brn-3a activates the expression of Bcl-x(L) and promotes neuronal survival in vivo as well as in vitro. Mol Cell Neurosci. 2001;17:460-70 pubmed
    ..Most importantly, both Bcl-x(L) expression and neuronal survival are enhanced by the overexpression of Brn-3a in dorsal root ganglion in vivo in a model of sciatic nerve injury in the intact animal. ..
  17. Cabart P, Murphy S. BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein. J Biol Chem. 2001;276:43056-64 pubmed
    ..Therefore, the polymerase recruitment is not simply determined by the sequence of the TATA-box and immediate flanking sequences. ..
  18. French C, Masson J, Griffin C, O Regan P, West S, Thacker J. Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J Biol Chem. 2002;277:19322-30 pubmed publisher
    ..Our results demonstrate that RAD51L2 has a key role in mammalian RAD51-dependent processes, contingent on the formation of protein complexes involved in homologous recombination repair...
  19. Anderson L, Perkins N. The large subunit of replication factor C interacts with the histone deacetylase, HDAC1. J Biol Chem. 2002;277:29550-4 pubmed
    ..Further analysis revealed that RFC (p140) contains two distinct transcriptional repression domains. Moreover, both of these domains interact separately with HDAC1. ..
  20. Nair M, McIntosh P, Frenkiel T, Kelly G, Taylor I, Smerdon S, et al. NMR structure of the DNA-binding domain of the cell cycle protein Mbp1 from Saccharomyces cerevisiae. Biochemistry. 2003;42:1266-73 pubmed
    ..The fold-back structure extends the region of positive electrostatic potential, and this may enhance the nonspecific contribution to binding by favorable electrostatic interactions with the DNA backbone. ..
  21. Stiff T, O Driscoll M, Rief N, Iwabuchi K, Lobrich M, Jeggo P. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 2004;64:2390-6 pubmed
    ..However, by phosphorylating H2AX, DNA-PK can contribute to the presence of the damage response proteins MDC1 and 53BP1 at the site of the DSB. ..
  22. Loizou J, El Khamisy S, Zlatanou A, Moore D, Chan D, Qin J, et al. The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. Cell. 2004;117:17-28 pubmed
    ..These data identify a direct role for CK2 in the repair of chromosomal DNA strand breaks and in maintaining genetic integrity. ..
  23. Ng R, Gurdon J. Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer. Proc Natl Acad Sci U S A. 2005;102:1957-62 pubmed
    ..We conclude that an epigenetic memory is established in differentiating somatic cells and applies to genes that are in a transcriptionally active state. ..
  24. Stucki M, Clapperton J, Mohammad D, Yaffe M, Smerdon S, Jackson S. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell. 2005;123:1213-26 pubmed
    ..Thus, binding of MDC1/NFBD1 to gammaH2AX plays a central role in the mammalian response to DNA damage. ..
  25. Sourisseau T, Georgiadis A, Tsapara A, Ali R, Pestell R, Matter K, et al. Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA. Mol Cell Biol. 2006;26:2387-98 pubmed
  26. Devlin L, Graham C, Price J, Morrison P. Germline MSH6 mutations are more prevalent in endometrial cancer patient cohorts than hereditary non polyposis colorectal cancer cohorts. Ulster Med J. 2008;77:25-30 pubmed
    ..HNPCC families may be ascertained through an individual presenting with EC, and recognition of these families is important so that appropriate cancer surveillance can be put in place. ..
  27. Egloff S, Al Rawaf H, O Reilly D, Murphy S. Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genes. Mol Cell Biol. 2009;29:4002-13 pubmed publisher
    ..Furthermore, CTCF colocalizes with NELF on the U2 and beta-actin genes, raising the possibility that it helps the positioning and/or function of the NELF-dependent control point on these genes. ..
  28. Ramanjaneya M, Chen J, Brown J, Tripathi G, Hallschmid M, Patel S, et al. Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinology. 2010;151:3169-80 pubmed publisher
    ..05) and showed positive correlation with body mass index in human. We report that nesfatin-1 is a novel depot specific adipokine preferentially produced by sc tissue, with obesity- and food deprivation-regulated expression. ..
  29. Holmes L, Campbell S, De Long S, Sachs A, Ashe M. Loss of translational control in yeast compromised for the major mRNA decay pathway. Mol Cell Biol. 2004;24:2998-3010 pubmed
    ..Therefore, these mutants appear translationally oblivious to decreased ternary complex abundance, and we propose that this is due to higher rates of mRNA recruitment to the 40S ribosomal subunit. ..
  30. Robins P, Pappin D, Wood R, Lindahl T. Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I. J Biol Chem. 1994;269:28535-8 pubmed
    ..The protein sequence retains conserved residues and shows significant homology to the sequences of the 5'-nuclease domain of E. coli DNA polymerase I and related microbial enzymes. ..
  31. Cammas F, Pullinger G, Barker S, Clark A. The mouse adrenocorticotropin receptor gene: cloning and characterization of its promoter and evidence for a role for the orphan nuclear receptor steroidogenic factor 1. Mol Endocrinol. 1997;11:867-76 pubmed
    ..The other as yet unknown factor binding between position -1236 bp and -908 bp acts as a strong inhibitory factor in nonadrenal steroidogenic cells, resulting in the adrenal-specific expression of ACTH-R. ..
  32. Landini P, Busby S. The Escherichia coli Ada protein can interact with two distinct determinants in the sigma70 subunit of RNA polymerase according to promoter architecture: identification of the target of Ada activation at the alkA promoter. J Bacteriol. 1999;181:1524-9 pubmed
    ..We propose that meAda can activate transcription at different promoters by contacting distinct determinants in sigma70 region 4 in a manner dependent on the location of the Ada binding site. ..
  33. Smith G, Cary R, Lakin N, Hann B, Teo S, Chen D, et al. Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM. Proc Natl Acad Sci U S A. 1999;96:11134-9 pubmed
  34. Caspari T, Dahlen M, Kanter Smoler G, Lindsay H, Hofmann K, Papadimitriou K, et al. Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9. Mol Cell Biol. 2000;20:1254-62 pubmed
    ..However, two-hybrid interaction, in vitro association and in vivo overexpression experiments suggest a transient interaction between Rad1 and Rad17. ..
  35. Buck M, Gallegos M, Studholme D, Guo Y, Gralla J. The bacterial enhancer-dependent sigma(54) (sigma(N)) transcription factor. J Bacteriol. 2000;182:4129-36 pubmed
  36. Shikama N, Chan H, Krstic Demonacos M, Smith L, Lee C, Cairns W, et al. Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators. Mol Cell Biol. 2000;20:8933-43 pubmed
    ..These results argue that NAP is a functionally important component of the p300 coactivator complex and suggest that NAP may serve as a point of integration between transcriptional coactivators and chromatin. ..
  37. Bemark M, Sale J, Kim H, Berek C, Cosgrove R, Neuberger M. Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity. J Exp Med. 2000;192:1509-14 pubmed
  38. Touitou R, Hickabottom M, Parker G, Crook T, Allday M. Physical and functional interactions between the corepressor CtBP and the Epstein-Barr virus nuclear antigen EBNA3C. J Virol. 2001;75:7749-55 pubmed
    ..A striking correlation between CtBP binding and the capacity of EBNA3C to cooperate with (Ha-)Ras in the immortalization and transformation of primary rat embryo fibroblasts was also revealed. ..
  39. Sansom O, Stark L, Dunlop M, Clarke A. Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice. Cancer Res. 2001;61:7060-4 pubmed
    ..Thus embryonic and perinatal exposure to aspirin suppresses neoplasia specifically associated with the loss of Apc function, opening a potential window of opportunity for nonsteroidal anti-inflammatory drug intervention. ..
  40. Bao Y, Cook L, O Donovan D, Uyama E, Rubinsztein D. Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy. J Biol Chem. 2002;277:12263-9 pubmed
  41. Murai K, Treisman R. Interaction of serum response factor (SRF) with the Elk-1 B box inhibits RhoA-actin signaling to SRF and potentiates transcriptional activation by Elk-1. Mol Cell Biol. 2002;22:7083-92 pubmed
    ..Combinatorial interactions between SRF and TCF proteins are thus likely to play an important role in determining the relative sensitivity of SRF target genes to Ras- and Rho-controlled signal transduction pathways. ..
  42. Oakley F, Mann J, Ruddell R, Pickford J, Weinmaster G, Mann D. Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1. J Biol Chem. 2003;278:24359-70 pubmed
    ..Taken together, these data suggest that basal IkappaBalpha expression (and as a consequence NF-kappaB activity) is under the control of the various components of the CBF1/Notch signal transduction pathway. ..
  43. MacDougall M, Europe Finner G, Robson S. Human myometrial quiescence and activation during gestation and parturition involve dramatic changes in expression and activity of particulate type II (RII alpha) protein kinase A holoenzyme. J Clin Endocrinol Metab. 2003;88:2194-205 pubmed
  44. McCormack M, Forster A, Drynan L, Pannell R, Rabbitts T. The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development. Mol Cell Biol. 2003;23:9003-13 pubmed
    ..We conclude that there is no mandatory role for LMO2 in lymphoid development, implying that its specific role in T-cell tumorigenesis results from a reprogramming of gene expression after enforced expression in T-cell precursors...
  45. Zoumpoulidou G, Jones M, Fernandez De Mattos S, Francis J, Fusi L, Lee Y, et al. Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y). Mol Endocrinol. 2004;18:1988-99 pubmed
  46. La Rocca S, Herbert R, Crooke H, Drew T, Wileman T, Powell P. Loss of interferon regulatory factor 3 in cells infected with classical swine fever virus involves the N-terminal protease, Npro. J Virol. 2005;79:7239-47 pubmed
    ..The results demonstrate a novel viral evasion of innate host defenses, where interferon synthesis is prevented by inhibiting transcription of IRF3 in CSFV-infected cells. ..
  47. Ribas R, Taylor J, McCorquodale C, Maurício A, Sousa M, Wilmut I. Effect of zona pellucida removal on DNA methylation in early mouse embryos. Biol Reprod. 2006;74:307-13 pubmed
    ..Similarly, no differences were found regarding the onset of transcription of Dnmt1s, Nanog, and Fgf4 genes...
  48. Liu Y, Tarsounas M, O Regan P, West S. Role of RAD51C and XRCC3 in genetic recombination and DNA repair. J Biol Chem. 2007;282:1973-9 pubmed
  49. Truman A, Millson S, Nuttall J, Mollapour M, Prodromou C, Piper P. In the yeast heat shock response, Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 (Mpk1) mitogen-activated protein kinase required for cell integrity. Eukaryot Cell. 2007;6:744-52 pubmed
  50. Oxley C, Anthis N, Lowe E, Vakonakis I, Campbell I, Wegener K. An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding. J Biol Chem. 2008;283:5420-6 pubmed
    ..This switch may represent an in vivo mechanism for control of integrin receptor activation. These results have implications for the control of integrin signaling by proteins containing phosphotyrosine binding domains. ..
  51. Brady G, Whiteman H, Spender L, Farrell P. Downregulation of RUNX1 by RUNX3 requires the RUNX3 VWRPY sequence and is essential for Epstein-Barr virus-driven B-cell proliferation. J Virol. 2009;83:6909-16 pubmed publisher
    ..The results demonstrate the importance of RUNX3-mediated repression of RUNX1 for EBV-driven B-cell proliferation and identify functional differences between human RUNX family proteins. ..
  52. Smith M, Dawson S, Latchman D. Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor. J Biol Chem. 1997;272:1382-8 pubmed
    ..Hence a single amino acid difference results in these closely related factors having opposite effects and allows the balance between them to regulate differentiation. ..
  53. Sözen M, Armstrong J, Yang M, Kaiser K, Dow J. Functional domains are specified to single-cell resolution in a Drosophila epithelium. Proc Natl Acad Sci U S A. 1997;94:5207-12 pubmed
    ..Building upon recent advances in Drosophila Malpighian tubule physiology, the present study confirms this tissue as a singular model for integrative physiology...
  54. McGlynn P, Al Deib A, Liu J, Marians K, Lloyd R. The DNA replication protein PriA and the recombination protein RecG bind D-loops. J Mol Biol. 1997;270:212-21 pubmed
    ..RecG, like PriA, binds D-loops and unwinds the DNA. However, it prefers branched structures with at least two duplex components. The possibility that it competes with PriA for binding recombination intermediates is discussed. ..
  55. Ferguson G, Creighton R, Nikolaev Y, Booth I. Importance of RpoS and Dps in survival of exposure of both exponential- and stationary-phase Escherichia coli cells to the electrophile N-ethylmaleimide. J Bacteriol. 1998;180:1030-6 pubmed
    ..A slower-growing E. coli strain was also found to accumulate RpoS and had enhanced resistance to NEM. These data emphasize the multiplicity of pathways involved in protecting E. coli cells against NEM. ..
  56. Desterro J, Rodriguez M, Hay R. SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell. 1998;2:233-9 pubmed
    ..Thus, while ubiquitination targets proteins for rapid degradation, SUMO-1 modification acts antagonistically to generate proteins resistant to degradation. ..
  57. Patek C, Little M, Fleming S, Miles C, Charlieu J, Clarke A, et al. A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome. Proc Natl Acad Sci U S A. 1999;96:2931-6 pubmed
    ..However, the mutant WT1(tmT396) protein accounted for only 5% of WT1 in both heterozygous embryonic stem cells and the WT. This has implications regarding the mechanism by which the mutant allele exerts its effect. ..
  58. Bingham C, Bulman M, Ellard S, Allen L, Lipkin G, Hoff W, et al. Mutations in the hepatocyte nuclear factor-1beta gene are associated with familial hypoplastic glomerulocystic kidney disease. Am J Hum Genet. 2001;68:219-24 pubmed
    ..We conclude that there is genetic heterogeneity in familial GCKD and that the hypoplastic subtype is a part of the clinical spectrum of the renal cysts and diabetes syndrome that is associated with HNF-1beta mutations. ..
  59. Wu L, Davies S, Levitt N, Hickson I. Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51. J Biol Chem. 2001;276:19375-81 pubmed
    ..Furthermore, genetic analysis reveals that the SGS1 and RAD51 genes are epistatic indicating that they operate in a common pathway. Potential roles for BLM in the RAD51 recombinational repair pathway are discussed. ..
  60. Przyborski S. Isolation of human embryonal carcinoma stem cells by immunomagnetic sorting. Stem Cells. 2001;19:500-4 pubmed
  61. Bolt E, Lloyd R. Substrate specificity of RusA resolvase reveals the DNA structures targeted by RuvAB and RecG in vivo. Mol Cell. 2002;10:187-98 pubmed
    ..We present evidence that replication restart in UV-irradiated cells relies on the processing of stalled replication forks by RecG helicase and of Holliday junctions by the RuvABC resolvasome, and that RuvAB alone may not promote repair. ..
  62. Buehr M, Nichols J, Stenhouse F, Mountford P, Greenhalgh C, Kantachuvesiri S, et al. Rapid loss of Oct-4 and pluripotency in cultured rodent blastocysts and derivative cell lines. Biol Reprod. 2003;68:222-9 pubmed
    ..Downregulation of Oct-4 appears to be a limiting factor in attempts to derive pluripotent cell lines from preimplantation embryos. ..
  63. Yang S, Jaffray E, Hay R, Sharrocks A. Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. Mol Cell. 2003;12:63-74 pubmed
    ..Thus, the reciprocal regulation of the activation and repressive activities are coupled by MAP kinase modification of Elk-1. ..
  64. Alonso M, Zoidl G, Taveggia C, Bosse F, Zoidl C, Rahman M, et al. Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system. J Biol Chem. 2004;279:25653-64 pubmed
    ..Zfp-57 mRNA is up-regulated in Schwann cells in response to leukemia inhibitory factor and fibroblast growth factor 2...
  65. Coutinho A, Borday C, Gilthorpe J, Jungbluth S, Champagnat J, Lumsden A, et al. Induction of a parafacial rhythm generator by rhombomere 3 in the chick embryo. J Neurosci. 2004;24:9383-90 pubmed
    ..The r4 rhythm generator appears to be homologous to a murine respiratory parafacial neuronal system developing in r4 under the control of Krox20 and Hoxa1. These results identify a late role for Krox20 at the onset of neurogenesis. ..
  66. Rochford J, Semple R, Laudes M, Boyle K, Christodoulides C, Mulligan C, et al. ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis. Mol Cell Biol. 2004;24:9863-72 pubmed
    ..These findings define, for the first time, a molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta and a novel regulator of early adipogenesis. ..
  67. Hamada F, Bienz M. The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. Dev Cell. 2004;7:677-85 pubmed
    ..Our evidence indicates that APC is an adaptor between beta-catenin and CtBP and that CtBP lowers the availability of free nuclear beta-catenin for binding to TCF by sequestering APC/beta-catenin complexes. ..
  68. Jones M, Davidson A, Hibbert L, Gruenwald P, Schlaak J, Ball S, et al. Dengue virus inhibits alpha interferon signaling by reducing STAT2 expression. J Virol. 2005;79:5414-20 pubmed
    ..Collectively, these data show that dengue virus is capable of subverting the human IFN response by down-regulating STAT2 expression. ..
  69. Ciccia A, McDonald N, West S. Structural and functional relationships of the XPF/MUS81 family of proteins. Annu Rev Biochem. 2008;77:259-87 pubmed publisher
    ..Determining how these enzymes recognize specific DNA substrates and promote key repair reactions is an important challenge for the future. ..
  70. Clifford R, Deacon K, Knox A. Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1: requirement for Smads, (beta)-CATENIN, AND GSK3(beta). J Biol Chem. 2008;283:35337-53 pubmed publisher
    ..These results provide new insight into the molecular regulation of VEGF by two interacting pathways necessary for vascular development, maintenance, and disease. ..
  71. Byrne S, Cunniffe S, O Neill P, Lomax M. 5,6-Dihydrothymine impairs the base excision repair pathway of a closely opposed AP site or single-strand break. Radiat Res. 2009;172:537-49 pubmed publisher
    ..In addition, immunodepletion of XRCC1 from the nuclear extracts slows down the initial rate of repair of the AP site in both the presence and absence of DHT, but immunodepletion of XRCC1 has no influence on the repair of an SSB. ..
  72. Tay Y, Wu L. Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing. J Biol Chem. 2010;285:11427-32 pubmed publisher
    ..Together, these results suggest a direct role for Yen1 in the response to DNA damage and implicate overlapping HJ resolution functions of Yen1 with Mus81 during replication fork repair. ..
  73. Shibata A, Barton O, Noon A, Dahm K, Deckbar D, Goodarzi A, et al. Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest. Mol Cell Biol. 2010;30:3371-83 pubmed publisher
    ..The combined repair and checkpoint defects conferred by 53BP1 and MDC1 deficiency act synergistically to enhance chromosome breakage. ..
  74. Beattie J, Wood A, Newman A, Bremner I, Choo K, Michalska A, et al. Obesity and hyperleptinemia in metallothionein (-I and -II) null mice. Proc Natl Acad Sci U S A. 1998;95:358-63 pubmed
    ..Targeted disruption of MT-I and MT-II genes seems to induce moderate obesity, providing a new obese animal model. A link between MT and the regulation of energy balance is implied. ..
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