Experts and Doctors on dna binding proteins in Japan

Summary

Locale: Japan
Topic: dna binding proteins

Top Publications

  1. Sudo T, Ozawa K, Soeda E, Nomura N, Ishii S. Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24. Genomics. 1992;12:167-70 pubmed
    ..The gene was further localized to the region 6q23-24 by fluorescence in situ hybridization. ..
  2. Nakashima K, Kanamaru K, Aiba H, Mizuno T. Signal transduction and osmoregulation in Escherichia coli. A novel type of mutation in the phosphorylation domain of the activator protein, OmpR, results in a defect in its phosphorylation-dependent DNA binding. J Biol Chem. 1991;266:10775-80 pubmed
    ..The mutant proteins characterized in this study seem to be defective in this particular oligomerization process observed in vitro. ..
  3. Tamura K, Taniguchi Y, Minoguchi S, Sakai T, Tun T, Furukawa T, et al. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol. 1995;5:1416-23 pubmed
    ..RBP-J kappa/Su(H) does not appear to interact with Notch via the CDC10/ankyrin repeats implicated in previous studies. ..
  4. Yasunami M, Suzuki K, Ohkubo H. A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns. Biochem Biophys Res Commun. 1996;228:365-70 pubmed
  5. Matsumoto A, Masuhara M, Mitsui K, Yokouchi M, Ohtsubo M, Misawa H, et al. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood. 1997;89:3148-54 pubmed
    ..Thus, CIS is a feedback modulator of STAT5; its expression is induced by STAT5 and it negatively modulates STAT5 activation. ..
  6. Ikeda K, Inoue S, Orimo A, Sano M, Watanabe T, Tsutsumi K, et al. Multiple regulatory elements and binding proteins of the 5'-flanking region of the human estrogen-responsive finger protein (efp) gene. Biochem Biophys Res Commun. 1997;236:765-71 pubmed
    ..These findings suggest that the human efp promoter is regulated by multiple elements and their interacting factors, and the E-box near the transcription initiation site is essential for the basal promoter activity. ..
  7. Tanaka T, Nakamura T, Takagi H, Sato M. Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP. Biochem Biophys Res Commun. 1997;239:176-81 pubmed
    ..We provide evidence that expression of TBPIP enhances the inhibitory action of TBP-1 on Tat-mediated transactivation in vitro. Our results suggest that TBPIP may have a key role in suppressing the Tat-mediated transactivation. ..
  8. Nishimura M, Isaka F, Ishibashi M, Tomita K, Tsuda H, Nakanishi S, et al. Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split. Genomics. 1998;49:69-75 pubmed
    ..These results suggest that Hes genes are functionally classified into two groups: those that are regulated by Notch and those that are not. ..
  9. Kubota T, Miyauchi M, Miura K, Hirokawa G, Awaya A, Miyasaka N, et al. Upregulation of nucleobindin expression in human-activated lymphocytes and non-Hodgkin's lymphoma. Pathol Int. 1998;48:22-8 pubmed
    ..In addition, it might be applicable to the clinicopathological estimation of NHL as a novel indicator. ..

More Information

Publications178 found, 100 shown here

  1. Matsumoto M, Sakao Y, Akira S. Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha, osteopontin and CD14 in a monocytic leukemia cell line. Int Immunol. 1998;10:1825-35 pubmed
    ..These findings indicate that MIP-1 alpha is a direct target of NF-IL6. ..
  2. Sugahara K, Sadohara T, Sugita M, Iyama K, Takiguchi M. Differential expression of CCAAT enhancer binding protein family in rat alveolar epithelial cell proliferation and in acute lung injury. Cell Tissue Res. 1999;297:261-70 pubmed
  3. Matsumoto M, Tanaka T, Kaisho T, Sanjo H, Copeland N, Gilbert D, et al. A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages. J Immunol. 1999;163:5039-48 pubmed
    ..The Mincle gene locus was mapped at 0.6 centiMorgans proximal to CD4 on mouse chromosome 6. ..
  4. Asai A, Yano K, Mizukami T, Nakano H. Characterization of a duocarmycin-DNA adduct-recognizing protein in cancer cells. Cancer Res. 1999;59:5417-20 pubmed
    ..These results demonstrate that DARP recognizes the structural alteration of DNA induced by these potent DNA-alkylating drugs, suggesting the possibility that the protein might modulate the antitumor activity of these drugs. ..
  5. Ikeda H, Yatomi Y, Yanase M, Satoh H, Maekawa H, Ogata I, et al. Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2000;279:G304-10 pubmed
    ..Considering that HSCs are capable of production of extracellular matrices and modulation of blood flow in sinusoids, our results suggest that S-1-P may play a role in wound healing process in the liver...
  6. Fukumoto T, Watanabe Fukunaga R, Fujisawa K, Nagata S, Fukunaga R. The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells. J Biol Chem. 2001;276:38441-8 pubmed
  7. Kawasaki C, Ohshim K, Suzumiya J, Kanda M, Tsuchiya T, Tamura K, et al. Rearrangements of bcl-1, bcl-2, bcl-6, and c-myc in diffuse large B-cell lymphomas. Leuk Lymphoma. 2001;42:1099-106 pubmed
    ..However, other genetic factors are probably involved in determining prognosis. ..
  8. Miwa N, Furuse M, Tsukita S, Niikawa N, Nakamura Y, Furukawa Y. Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers. Oncol Res. 2001;12:469-76 pubmed
    ..Our results imply that claudin-1 is involved in the beta-catenin-Tcf/LEF signaling pathway, and that increased expression of claudin-1 may have some role in colorectal tumorigenesis. ..
  9. Maeda K, Nishiyama C, Tokura T, Akizawa Y, Nishiyama M, Ogawa H, et al. Regulation of cell type-specific mouse Fc epsilon RI beta-chain gene expression by GATA-1 via four GATA motifs in the promoter. J Immunol. 2003;170:334-40 pubmed
    ..These results indicate that cell type-specific transcription of mouse beta-chain gene is regulated by GATA-1. ..
  10. Kanai M, Konda Y, Nakajima T, Izumi Y, Kanda N, Nanakin A, et al. Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway. Oncogene. 2003;22:548-54 pubmed
  11. Sato M, Kawai Kowase K, Sato H, Oyama Y, Kanai H, Ohyama Y, et al. c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells. Arterioscler Thromb Vasc Biol. 2005;25:341-7 pubmed
    ..These results indicate that c-Src and hydrogen peroxide are required for TGF-beta1 signaling. ..
  12. Kozu T, Fukuyama T, Yamami T, Akagi K, Kaneko Y. MYND-less splice variants of AML1-MTG8 (RUNX1-CBFA2T1) are expressed in leukemia with t(8;21). Genes Chromosomes Cancer. 2005;43:45-53 pubmed
    ..Thus, expression of the MYND-less variants by the dysregulation of splicing machinery, which stimulates the oligomerization of fusion proteins in leukemia cells, may enhance malignant conversion of hematopoietic cells. ..
  13. Otsuka M, Kato N, Moriyama M, Taniguchi H, Wang Y, Dharel N, et al. Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses. Hepatology. 2005;41:1004-12 pubmed publisher
    ..In conclusion, these results suggest the mechanisms of the inhibition of the innate immune responses of HCV infection by NS3 protein...
  14. Noutoshi Y, Ito T, Seki M, Nakashita H, Yoshida S, Marco Y, et al. A single amino acid insertion in the WRKY domain of the Arabidopsis TIR-NBS-LRR-WRKY-type disease resistance protein SLH1 (sensitive to low humidity 1) causes activation of defense responses and hypersensitive cell death. Plant J. 2005;43:873-88 pubmed
  15. Yamazaki T, Yamagata K, Baba T. Time-lapse and retrospective analysis of DNA methylation in mouse preimplantation embryos by live cell imaging. Dev Biol. 2007;304:409-19 pubmed
    ..These ROSI oocytes showed a significantly low rate of 2-cell formation, thus suggesting that the poor embryonic development of the ROSI oocytes may result from the abnormal localization of methylated chromatin. ..
  16. Yamamoto N, Maeda Y, Ikeda A, Sakurai H. Regulation of thermotolerance by stress-induced transcription factors in Saccharomyces cerevisiae. Eukaryot Cell. 2008;7:783-90 pubmed publisher
    ..These results show that Hsf1 and Msn2/4 act differentially before and after exposure to extreme temperatures to ensure cell survival and growth. ..
  17. Kuribayashi T, Ohara M, Sora S, Kubota N. Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation. Int J Mol Med. 2010;25:25-9 pubmed
    ..In addition, treatment with scriptaid suppressed expression of Ku80, but not Ku70. Scriptaid may be a useful radiosensitizer in the treatment of radioresistant human carcinomas. ..
  18. Takahashi A, Mori E, Ohnishi T. The foci of DNA double strand break-recognition proteins localize with gammaH2AX after heat treatment. J Radiat Res. 2010;51:91-5 pubmed
    ..These results are discussed from perspectives of heat-induced denaturation of proteins and formation of DSBs. ..
  19. Tominaga K, Akiyama S, Kagawa Y, Ohta S. Upstream region of a genomic gene for human mitochondrial transcription factor 1. Biochim Biophys Acta. 1992;1131:217-9 pubmed
    ..There were, at least, four common sequences among some nuclear genes for mitochondrial-related proteins. ..
  20. Yoda K, Nakamura T, Masumoto H, Suzuki N, Kitagawa K, Nakano M, et al. Centromere protein B of African green monkey cells: gene structure, cellular expression, and centromeric localization. Mol Cell Biol. 1996;16:5169-77 pubmed
  21. Song J, Murakami H, Tsutsui H, Ugai H, Geltinger C, Murata T, et al. Structural organization and expression of the mouse gene for Pur-1, a highly conserved homolog of the human MAZ gene. Eur J Biochem. 1999;259:676-83 pubmed
    ..This region also mediated stimulation of basal transcription by ectopically expressed MAZ protein. We conclude that the Pur-1 gene is the murine homolog of human MAZ and, like it, belongs to the family of housekeeping genes. ..
  22. Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, et al. XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription. J Biol Chem. 2000;275:34931-7 pubmed
    ..These results indicate that XAB2 is a novel component involved in transcription-coupled repair and transcription. ..
  23. Miyase S, Tateishi S, Watanabe K, Tomita K, Suzuki K, Inoue H, et al. Differential regulation of Rad18 through Rad6-dependent mono- and polyubiquitination. J Biol Chem. 2005;280:515-24 pubmed
    ..These results suggest that the amount of Rad18 in the nucleus is regulated differentially by mono- and polyubiquitination. ..
  24. Jin W, Takagi T, Kanesashi S, Kurahashi T, Nomura T, Harada J, et al. Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins. Dev Cell. 2006;10:461-71 pubmed
    ..Shn-2 directly interacts with both Smad1/4 and C/EBPalpha on the PPARgamma2 promoter. These results indicate that Shn-2-mediated BMP signaling has a critical role in adipogenesis. ..
  25. Kitagawa K, Masumoto H, Ikeda M, Okazaki T. Analysis of protein-DNA and protein-protein interactions of centromere protein B (CENP-B) and properties of the DNA-CENP-B complex in the cell cycle. Mol Cell Biol. 1995;15:1602-12 pubmed
  26. Matsuo T, Osumi Yamashita N, Noji S, Ohuchi H, Koyama E, Myokai F, et al. A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells. Nat Genet. 1993;3:299-304 pubmed
  27. Urahama N, Ito M, Sada A, Yakushijin K, Yamamoto K, Okamura A, et al. The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation. Genes Cells. 2005;10:1127-37 pubmed
    ..These results indicated a crucial role of TRAP220 in the optimal VDR- and RAR-mediated myelomonocytic differentiation processes in mammalian hematopoiesis. ..
  28. Sato H, Tsukada T, Nagayoshi M, Ikawa Y, Aizawa S, Kato M. Repression of p53-dependent sequence-specific transactivation by MEF2c. Biochem Biophys Res Commun. 1995;214:468-74 pubmed
    ..Clone 2 repressed the transactivation from Fragment A by p53, suggesting that MEF2c may act as a negative regulator of p53-responsive element. ..
  29. Hao Z, Furunobu A, Nagata A, Okayama H. A zinc finger protein required for stationary phase viability in fission yeast. J Cell Sci. 1997;110 ( Pt 20):2557-66 pubmed
    ..Analysis also showed that cells need to receive starvation signals before entry into the stationary phase in order to maintain viability in a glucose-poor environment. ..
  30. Itoh T, Liu R, Arai K, Watanabe S. Differential influence of tyrosine residues of the common receptor beta subunit on multiple signals induced by human GM-CSF. J Allergy Clin Immunol. 1999;103:S462-70 pubmed
    ..In addition, GM-CSF may activate both beta subunit tyrosine-dependent and -independent pathways, with the latter being sufficient to transmit survival signals. ..
  31. Tezel G, Nagasaka T, Iwahashi N, Asai N, Iwashita T, Sakata K, et al. Different nuclear/cytoplasmic distributions of RET finger protein in different cell types. Pathol Int. 1999;49:881-6 pubmed
    ..These results suggested that different nuclear/cytoplasmic distributions of RFP might play a role in the regulation of growth or differentiation of different cell types. ..
  32. Mataga N, Fujishima S, Condie B, Hensch T. Experience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268. J Neurosci. 2001;21:9724-32 pubmed
    ..Our findings underscore a mechanistic distinction between sensory plasticity and long-lasting forms of synaptic potentiation in the hippocampus, for which egr1/zif268 was recently found to be essential. ..
  33. Furukawa Hibi Y, Yoshida Araki K, Ohta T, Ikeda K, Motoyama N. FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress. J Biol Chem. 2002;277:26729-32 pubmed
    ..Our results suggest that the FOXO family of transcription factors plays an important role in the regulation of GADD45 in response to oxidative stress and thereby contributes to G(2)-M checkpoint. ..
  34. Miyazaki A, Shimura H, Endo T, Haraguchi K, Onaya T. Tumor necrosis factor-alpha and interferon-gamma suppress both gene expression and deoxyribonucleic acid-binding of TTF-2 in FRTL-5 cells. Endocrinology. 1999;140:4214-20 pubmed
    ..These data suggest that TTF-2 is involved in the TNF-alpha and IFN-gamma-induced suppression of thyroid-specific gene expression. ..
  35. Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, et al. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med. 2005;201:915-23 pubmed
    ..These results indicated that IRAK-1 is a specific regulator for TLR7- and TLR9-mediated IFN-alpha induction in pDCs. ..
  36. Iida M, Matsuda M, Komatani H. Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site that is not recognized by Plk1. Biochem J. 2008;411:27-32 pubmed
    ..These data suggest that topoisomerase IIalpha is a novel physiological substrate for Plk3 and that Plk1 and Plk3 play different roles in cell-cycle regulation. ..
  37. Imataka H, Mizuno A, Fujii Kuriyama Y, Hayami M. Activation of the human immunodeficiency virus type 1 long terminal repeat by BTEB, a GC box-binding transcription factor. AIDS Res Hum Retroviruses. 1993;9:825-31 pubmed
    ..These results suggest that BTEB, like Sp1, is involved in transcriptional activation of the HIV-1 LTR. ..
  38. Fujimori K, Anamnart S, Nakagawa Y, Sugioka S, Ohta D, Oshima Y, et al. Isolation and characterization of mutations affecting expression of the delta9- fatty acid desaturase gene, OLE1, in Saccharomyces cerevisiae. FEBS Lett. 1997;413:226-30 pubmed
    ..We also demonstrated that TUP1 and SSN6 gene products are required for full repression of OLE1 gene expression, by showing that either tup1 or ssn6 mutations greatly increase the level of the OLE1 transcript. ..
  39. Lee H, Masuda E, Arai N, Arai K, Yokota T. Definition of cis-regulatory elements of the mouse interleukin-5 gene promoter. Involvement of nuclear factor of activated T cell-related factors in interleukin-5 expression. J Biol Chem. 1995;270:17541-50 pubmed
    ..It thus seems likely that an NF-AT-related factor is involved in the regulation of IL-5 gene transcription. ..
  40. Takebayashi K, Akazawa C, Nakanishi S, Kageyama R. Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element. J Biol Chem. 1995;270:1342-9 pubmed
    ..These results raise the possibility that HES-5 expression in the developing nervous system is regulated by the GC stretch-binding protein. ..
  41. Fujiwara T, Hoshino T, Ooshima T, Sobue S, Hamada S. Purification, characterization, and molecular analysis of the gene encoding glucosyltransferase from Streptococcus oralis. Infect Immun. 2000;68:2475-83 pubmed
    ..These results indicate that S. oralis GTase may play an important role in the subsequent colonizing of mutans streptoccoci...
  42. Aono J, Yanagawa T, Itoh K, Li B, Yoshida H, Kumagai Y, et al. Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts. Biochem Biophys Res Commun. 2003;305:271-7 pubmed
    ..These results provide the first direct evidence that toxic arsenics impair the normal function of A170. Our findings provide a potential diagnostic tool for monitoring biotoxicity in cells and tissues in response to arsenic compounds. ..
  43. Takahashi C, Akiyama N, Kitayama H, Takai S, Noda M. Possible involvement of MSX-2 homeoprotein in v-ras-induced transformation. Leukemia. 1997;11 Suppl 3:340-3 pubmed
    ..Our findings not only suggest that the truncated version MSX-2 may act as a dominant suppressor of intact MSX-2 but also raise the possibility that MSX-2 gene may be an important downstream target for the Ras signaling pathways. ..
  44. Ogawa S, Matsuo K, Angata K, Yanagisawa K, Tanaka Y. Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene. Curr Genet. 1997;31:80-8 pubmed
    ..4) also have a free-standing ORF in loop 1 and loop 2, respectively. These results show that these group-I introns and the intronic ORFs have evolved from the same ancestral origin, but that these ORFs have been propagated independently. ..
  45. Kuramoto K, Uesaka T, Kimura A, Kobayashi M, Watanabe H, Katoh O. ZK7, a novel zinc finger gene, is induced by vascular endothelial growth factor and inhibits apoptotic death in hematopoietic cells. Cancer Res. 2000;60:425-30 pubmed
    ..Therefore, ZK7 protein may be involved in the inhibitory effect of VEGF on apoptotic cell death in human hematopoietic cells. ..
  46. Kobayakawa S, Miike K, Nakao M, Abe K. Dynamic changes in the epigenomic state and nuclear organization of differentiating mouse embryonic stem cells. Genes Cells. 2007;12:447-60 pubmed
    ..Thus, this experimental system should facilitate studies focusing on relationships between nuclear organization, epigenetic status and cell differentiation. ..
  47. Yazawa H, Iwahashi H, Kamisaka Y, Kimura K, Uemura H. Production of polyunsaturated fatty acids in yeast Saccharomyces cerevisiae and its relation to alkaline pH tolerance. Yeast. 2009;26:167-84 pubmed publisher
    ..The Accession No. for microarray data in the Center for Information Biology Gene Expression database is CBX68. ..
  48. Nakayama T, Kimura M. Memory Th1/Th2 cell generation controlled by Schnurri-2. Adv Exp Med Biol. 2010;684:1-10 pubmed
    ..A repressor molecule Shn-2 plays an important role in this process. ..
  49. Toda T, Shimanuki M, Saka Y, Yamano H, Adachi Y, Shirakawa M, et al. Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1. Mol Cell Biol. 1992;12:5474-84 pubmed
    ..These results suggest the functional importance of chromosome structure on the regulation of gene expression through the pap1 transcription factor. ..
  50. Hirata D, Yano K, Miyakawa T. Stress-induced transcriptional activation mediated by YAP1 and YAP2 genes that encode the Jun family of transcriptional activators in Saccharomyces cerevisiae. Mol Gen Genet. 1994;242:250-6 pubmed
    ..A high-copy-number plasmid bearing YAP2 mediated cadmium-induced transcriptional activation of this promoter. The inductions were prevented by the antioxidant N-acetyl-L-cysteine. ..
  51. Kanai Y, Kanai Azuma M, Noce T, Saido T, Shiroishi T, Hayashi Y, et al. Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J Cell Biol. 1996;133:667-81 pubmed
    ..Thus, these findings suggest that Sox17 may function as a transcriptional activator in the premeiotic germ cells, and that a splicing switch into t-Sox17 may lead to the loss of its function in the postmeiotic germ cells. ..
  52. Saijoh Y, Fujii H, Meno C, Sato M, Hirota Y, Nagamatsu S, et al. Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor. Genes Cells. 1996;1:239-52 pubmed
    ..A large proportion of pluripotent cell-specific genes appear to be downstream targets of Oct-3. ..
  53. Yamamoto M, Fujinuma M, Tanaka M, Drager U, McCaffery P. Sagittal band expression of COUP-TF2 gene in the developing cerebellum. Mech Dev. 1999;84:143-6 pubmed
    ..By postnatal day 5 the COUP-TF2 expression substantially decreases to low, but detectable, levels. ..
  54. Kanzaki Kato N, Tamakoshi T, Fu Y, Chandra A, Itakura T, Uezato T, et al. Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor A in cardiovascular morphogenesis. Cardiovasc Res. 2005;65:711-8 pubmed
    ..5 dpc and that all surviving mice had persistent truncus arteriosus. The results suggest that Foxc2- and ETA-expressing cells additively form the aorticopulmonary septum. ..
  55. Kuge S, Jones N, Nomoto A. Regulation of yAP-1 nuclear localization in response to oxidative stress. EMBO J. 1997;16:1710-20 pubmed
    ..We suggest therefore, that these cysteine residues are important in sensing the redox state of the cell and hence regulating yAP-1 activity...
  56. Kanoh J, Watanabe Y, Ohsugi M, Iino Y, Yamamoto M. Schizosaccharomyces pombe gad7+ encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation. Genes Cells. 1996;1:391-408 pubmed
    ..Gad7 is a phosphoprotein, whose activity may be regulated by protein kinases including the cAMP-dependent protein kinase (Pka1) and Wis1 osmosensory MAP kinase kinase. ..
  57. Daitoku H, Yamagata K, Matsuzaki H, Hatta M, Fukamizu A. Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes. 2003;52:642-9 pubmed
    ..These results indicate that signaling via PKB to FKHR can partly account for the effect of insulin to regulate the PGC-1 promoter activity via the IRSs. ..
  58. Yabe K, Nakajima H. Enzyme reactions and genes in aflatoxin biosynthesis. Appl Microbiol Biotechnol. 2004;64:745-55 pubmed
    ..This review will summarize the enzymatic steps and the genes in aflatoxin/sterigmatocystin biosynthesis. ..
  59. Katoh M, Katoh M. Comparative genomics on Wnt7a orthologs. Oncol Rep. 2005;13:777-80 pubmed
    ..Therefore, biological functions of rodent Wnt7a are not always consistent with those of human WNT7A due to promoter evolution. This is the first report on the rat Wnt7a gene and comparative genomics for Wnt7a orthologs. ..
  60. Kondow A, Hitachi K, Ikegame T, Asashima M. Bowline, a novel protein localized to the presomitic mesoderm, interacts with Groucho/TLE in Xenopus. Int J Dev Biol. 2006;50:473-9 pubmed
    ..This study indicates that Bowline is a novel protein interacting with Groucho/TLE and may play a role in somitogenesis in X. laevis. ..
  61. Inoue E, Yamauchi J. AMP-activated protein kinase regulates PEPCK gene expression by direct phosphorylation of a novel zinc finger transcription factor. Biochem Biophys Res Commun. 2006;351:793-9 pubmed
    ..RNA interference-mediated reduction of endogenous AREBP expression attenuates AMPK-induced PEPCK down-regulation. These results implicate AREBP as a novel key modulator of PEPCK gene expression regulated by AMPK. ..
  62. Koga M, Ishiguro H, Horiuchi Y, Albalushi T, Inada T, Iwata N, et al. Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population. Neurosci Lett. 2007;417:326-9 pubmed
    ..79, respectively). We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia. ..
  63. Enoki Y, Mukoda Y, Furutani C, Sakurai H. DNA-binding and transcriptional activities of human HSF4 containing mutations that associate with congenital and age-related cataracts. Biochim Biophys Acta. 2010;1802:749-53 pubmed publisher
    ..However, two missense mutations that have been associated with age-related cataract did not or only slightly alter HSF4 activity, implying that other genetic and environmental factors affect the functions of these mutant proteins. ..
  64. Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, et al. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J. 1993;12:2715-21 pubmed
    ..Our results indicate that the production of chimeric AML1-MTG8 protein, probably a chimeric transcription factor, may contribute to myeloid leukemogenesis. ..
  65. Nishikawa T, Nagadoi A, Yoshimura S, Aimoto S, Nishimura Y. Solution structure of the DNA-binding domain of human telomeric protein, hTRF1. Structure. 1998;6:1057-65 pubmed
    ..In addition to DNA recognition by the HTH variant, a flexible N-terminal arm of hTRF1 is likely to interact with DNA. ..
  66. Tobe T, Tatsuno I, Katayama E, Wu C, Schoolnik G, Sasakawa C. A novel chromosomal locus of enteropathogenic Escherichia coli (EPEC), which encodes a bfpT-regulated chaperone-like protein, TrcA, involved in microcolony formation by EPEC. Mol Microbiol. 1999;33:741-52 pubmed
    ..The 90 kDa protein was revealed to be intimin, a protein product of the eae gene, which is required for the EPEC attaching/effacing phenotype, suggesting a direct interaction of TrcA with intimin in the cytoplasmic compartment. ..
  67. Ye S, Maki K, Kitamura T, Sunaga S, Akashi K, Domen J, et al. Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor. Immunity. 1999;11:213-23 pubmed
    ..Therefore, this study reveals a potential role of Stat5 in T cell development and also implies that IL-7R may control the accessibility of the TCRgamma locus through Stat5-induced germline transcription. ..
  68. Nishinakamura R, Matsumoto Y, Matsuda T, Ariizumi T, Heike T, Asashima M, et al. Activation of Stat3 by cytokine receptor gp130 ventralizes Xenopus embryos independent of BMP-4. Dev Biol. 1999;216:481-90 pubmed
    ..A dominant-negative Stat3, in contrast, dorsalized Xenopus embryos, resulting in ectopic axis formation. We propose that Stat3-mediated signaling has the capacity to modify dorsoventral patterning in the early development of Xenopus. ..
  69. Omura Y, Nishio Y, Takemoto T, Ikeuchi C, Sekine O, Morino K, et al. SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene. BMB Rep. 2009;42:232-7 pubmed
    ..The effect of SAFB1 overexpression on Srebp-1c promoter was found only in the presence of RBMX. These results indicate a major role for SAFB1 in the activation of Srebp-1c through its interaction with RBMX. ..
  70. Maekawa T, Sakura H, Sudo T, Ishii S. Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1. J Biol Chem. 1989;264:14591-3 pubmed
    ..This represents the first demonstration of the structural feature of the protein that binds to the HIV-1 enhancer. ..
  71. Hishida T, Iwasaki H, Ishioka K, Shinagawa H. Molecular analysis of the Pseudomonas aeruginosa genes, ruvA, ruvB and ruvC, involved in processing of homologous recombination intermediates. Gene. 1996;182:63-70 pubmed
    ..The sequence alignments of the Ruv proteins were extended by incorporation of data about the putative ruv genes obtained from data banks, and the RuvB sequences were conspicuously more conserved than the RuvA and RuvC sequences. ..
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