Experts and Doctors on dna binding proteins in Germany


Locale: Germany
Topic: dna binding proteins

Top Publications

  1. Hoffmann U, Hecht R, Boldyreff B, Issinger O. Characterization of the cDNA and three processed pseudogenes from the murine protein kinase CK2 alpha subunit. Biochim Biophys Acta. 1995;1260:337-40 pubmed
    ..Genomic locus D would code for a protein of 82 amino acids, locus B for a protein of 132 amino acids and locus C product for the full length product of 391 amino acids as the murine cDNA. ..
  2. Hartmann C, Landgraf M, Bate M, Jackle H. Krüppel target gene knockout participates in the proper innervation of a specific set of Drosophila larval muscles. EMBO J. 1997;16:5299-309 pubmed
    ..Their muscle pattern is normal, but the patterns of neuromuscular innervation are specifically disarranged. The results suggest that the Kr target gene ko is required for proper innervation of specific muscles by RP motoneurons. ..
  3. Schneider R, Travers A, Muskhelishvili G. The expression of the Escherichia coli fis gene is strongly dependent on the superhelical density of DNA. Mol Microbiol. 2000;38:167-75 pubmed
    ..This strict dependence of fis expression on the superhelical density suggests that fis may be involved in 'fine-tuning' the homeostatic control mechanism of DNA supercoiling in E. coli. ..
  4. Kulms D, Schwarz T. Ultraviolet radiation inhibits interleukin-2-induced tyrosine phosphorylation and the activation of STAT5 in T lymphocytes. J Biol Chem. 2001;276:12849-55 pubmed
    ..Because STAT5-mediated IL-2 effects are vital for normal immune functions, inhibition of STAT5 signaling by UV may contribute to its well known immunosuppressive properties. ..
  5. Pandur P, Maurus D, Kuhl M. Increasingly complex: new players enter the Wnt signaling network. Bioessays. 2002;24:881-4 pubmed
  6. Wilken N, Senecal J, Scheer U, Dabauvalle M. Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex. Eur J Cell Biol. 1995;68:211-9 pubmed
  7. Hein H, Schluter C, Kulke R, Christophers E, Schroder J, Bartels J. Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene. Biochem Biophys Res Commun. 1997;237:537-42 pubmed
  8. Panitz F, Krain B, Hollemann T, Nordheim A, Pieler T. The Spemann organizer-expressed zinc finger gene Xegr-1 responds to the MAP kinase/Ets-SRF signal transduction pathway. EMBO J. 1998;17:4414-25 pubmed
    ..These findings define a cascade of events that links Xbra activity to the signal-regulated control of Xegr-1 transcription in the context of early mesoderm induction in Xenopus laevis. ..
  9. Zähringer H, Thevelein J, Nwaka S. Induction of neutral trehalase Nth1 by heat and osmotic stress is controlled by STRE elements and Msn2/Msn4 transcription factors: variations of PKA effect during stress and growth. Mol Microbiol. 2000;35:397-406 pubmed
    ..These results might help to elucidate the general connection between control by STREs, Msn2/Msn4 and PKA and, in particular, how these components play a role in control of trehalose metabolism. ..

More Information

Publications411 found, 100 shown here

  1. Krause K, Haugwitz U, Wasner M, Wiedmann M, MOssner J, Engeland K. Expression of the cell cycle phosphatase cdc25C is down-regulated by the tumor suppressor protein p53 but not by p73. Biochem Biophys Res Commun. 2001;284:743-50 pubmed
    ..This reveals functional differences between p73 and p53 in regulating cell division. ..
  2. Zhou Y, Dieterle M, Buche C, Kretsch T. The negatively acting factors EID1 and SPA1 have distinct functions in phytochrome A-specific light signaling. Plant Physiol. 2002;128:1098-108 pubmed
    ..These results indicate that EID1 and SPA1 are involved in different but interacting phyA-dependent signal transduction chains. ..
  3. Xia H, Brearley C, Elge S, Kaplan B, Fromm H, Mueller Roeber B. Arabidopsis inositol polyphosphate 6-/3-kinase is a nuclear protein that complements a yeast mutant lacking a functional ArgR-Mcm1 transcription complex. Plant Cell. 2003;15:449-63 pubmed
    ..RNA gel blot analysis and promoter-beta-glucuronidase reporter gene studies demonstrated AtIpk2beta gene expression in various organs tested. These data suggest a role for AtIpk2beta as a transcriptional control mediator in plants. ..
  4. Schraets D, Lehmann T, Dingermann T, Marschalek R. MLL-mediated transcriptional gene regulation investigated by gene expression profiling. Oncogene. 2003;22:3655-68 pubmed
    ..Microarray hybridization experiments revealed 197 potential target genes that are differentially expressed, providing new and important clues about MLL functions. ..
  5. Plotz G, Raedle J, Brieger A, Trojan J, Zeuzem S. N-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalpha. Nucleic Acids Res. 2003;31:3217-26 pubmed
    ..We also examined another human homologue of bacterial MutL, hMutLbeta (hMLH1-hPMS1). We show that hMutLbeta interacts as efficiently with hMutSalpha as hMutLalpha, and that it predominantly binds to hMutSalpha via hMLH1 as well. ..
  6. Kaiser F, Moroy T, Chang G, Horsthemke B, Lüdecke H. The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. J Biol Chem. 2003;278:38780-5 pubmed
    ..Using a luciferase reporter assay, we could demonstrate that the repressional function of TRPS1 is inhibited by RNF4. This finding suggests that RNF4 is a negative regulator of TRPS1 activity. ..
  7. Santagati F, Abe K, Schmidt V, Schmitt John T, Suzuki M, Yamamura K, et al. Identification of Cis-regulatory elements in the mouse Pax9/Nkx2-9 genomic region: implication for evolutionary conserved synteny. Genetics. 2003;165:235-42 pubmed
    ..We propose such an intersecting organization of cis-regulatory sequences in multigenic regions as a possible mechanism that maintains evolutionary conserved synteny. ..
  8. Kirik V, Simon M, Huelskamp M, Schiefelbein J. The ENHANCER OF TRY AND CPC1 gene acts redundantly with TRIPTYCHON and CAPRICE in trichome and root hair cell patterning in Arabidopsis. Dev Biol. 2004;268:506-13 pubmed
    ..These results suggest that ETC1, TRY, and CPC act in concert to repress the trichome cell fate in the shoot epidermis and the non-hair cell fate in the root epidermis. ..
  9. Depboylu C, Reinhart T, Takikawa O, Imai Y, Maeda H, Mitsuya H, et al. Brain virus burden and indoleamine-2,3-dioxygenase expression during lentiviral infection of rhesus monkey are concomitantly lowered by 6-chloro-2',3'-dideoxyguanosine. Eur J Neurosci. 2004;19:2997-3005 pubmed
    ..Thus, IDO induction is associated with reversible overt inflammatory events localized to areas of active viral replication in the SIV-infected brain. ..
  10. Grohmann K, Rossoll W, Kobsar I, Holtmann B, Jablonka S, Wessig C, et al. Characterization of Ighmbp2 in motor neurons and implications for the pathomechanism in a mouse model of human spinal muscular atrophy with respiratory distress type 1 (SMARD1). Hum Mol Genet. 2004;13:2031-42 pubmed
    ..g. Smn (survival motor neuron) deficient mice, the model of spinal muscular atrophy (SMA). Our data suggest that the pathomechanism in SMARD1 is clearly distinct from other motor neuron diseases such as classic SMA. ..
  11. Mangold E, Pagenstecher C, Friedl W, Mathiak M, Buettner R, Engel C, et al. Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer. Int J Cancer. 2005;116:692-702 pubmed
  12. Baumann C, Körner R, Hofmann K, Nigg E. PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell. 2007;128:101-14 pubmed
    ..These data identify PICH as a novel essential component of checkpoint signaling. We propose that PICH binds to catenated centromere-related DNA to monitor tension developing between sister kinetochores. ..
  13. Haarmann T, Lorenz N, Tudzynski P. Use of a nonhomologous end joining deficient strain (Deltaku70) of the ergot fungus Claviceps purpurea for identification of a nonribosomal peptide synthetase gene involved in ergotamine biosynthesis. Fungal Genet Biol. 2008;45:35-44 pubmed
    ..Mutants lacking the lpsA1 gene were shown to be incapable of producing ergotamine but were still able to produce ergocryptine, proving that LpsA1 is involved in ergotamine biosynthesis...
  14. T pffer S, M ller Schiffmann A, Matentzoglu K, Scheffner M, Steger G. Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. J Gen Virol. 2007;88:2956-65 pubmed publisher
    ..Our data suggest that reducing the level of PTPH1 may contribute to the oncogenic activity of high-risk genital E6 proteins...
  15. Lukowitz W, Schroder C, Glaser G, Hulskamp M, Tautz D. Regulatory and coding regions of the segmentation gene hunchback are functionally conserved between Drosophila virilis and Drosophila melanogaster. Mech Dev. 1994;45:105-15 pubmed
    ..Some of these contain consensus binding sites for transregulatory factors that are likely to control the respective expression domains...
  16. Gallert K, Ohanjan T, Daignan Fornier B, Lottspeich F, Krauss G. Enzymatic properties and inhibition by single-stranded autonomously replicating sequences of adenylosuccinate synthase from Saccharomyces cerevisiae. Eur J Biochem. 1996;239:487-93 pubmed
  17. Schlenstedt G, Smirnova E, Deane R, Solsbacher J, Kutay U, Gorlich D, et al. Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J. 1997;16:6237-49 pubmed
    ..L25 binds to Yrb4p and Pse1p and is released by Gsp1p-GTP. Consistent with its putative role as an import receptor for L25-like proteins, Yrb4p localizes to the cytoplasm, the nucleoplasm and the NPC. ..
  18. Roth A, Messer W. High-affinity binding sites for the initiator protein DnaA on the chromosome of Escherichia coli. Mol Microbiol. 1998;28:395-401 pubmed
    ..Except for oriC, these fragments contain only one or two consensus DnaA binding sites, DnaA boxes. The distribution of these high-affinity DnaA boxes on the chromosome is random. ..
  19. Hollemann T, Chen Y, Grunz H, Pieler T. Regionalized metabolic activity establishes boundaries of retinoic acid signalling. EMBO J. 1998;17:7361-72 pubmed
  20. Peters H, Balling R. Teeth. Where and how to make them. Trends Genet. 1999;15:59-65 pubmed
    ..This cascade provides a molecular model by which reciprocal tissue interactions are controlled. ..
  21. Toell A, Degenhardt S, Grabensee B, Carlberg C. Inhibitory effect of uremic solutions on protein-DNA-complex formation of the vitamin D receptor and other members of the nuclear receptor superfamily. J Cell Biochem. 1999;74:386-94 pubmed
    ..These results indicate that VDR is a target of substances in uremic solutions in vitro, but also to some extent other nuclear receptors (i.e., other endocrine signaling systems) may be affected by renal failure. ..
  22. Deibert M, Grazulis S, Janulaitis A, Siksnys V, Huber R. Crystal structure of MunI restriction endonuclease in complex with cognate DNA at 1.7 A resolution. EMBO J. 1999;18:5805-16 pubmed
    ..The local conformation of AATT deviates from the typical B-DNA form and is remarkably similar to EcoRI-DNA. It appears to be essential for specific hydrogen bonding and recognition by MunI and EcoRI. ..
  23. Drechsler M, Schumacher V, Friedrich S, Wildhardt G, Giesler S, Schroth A, et al. Genomic structure, alternative transcripts and chromosome location of the human LIM domain binding protein 1 gene LDB1. Cytogenet Cell Genet. 1999;87:119-24 pubmed
    ..Fine mapping with a radiation hybrid panel localized the gene in the interval between the markers D10S603 and D10S540. ..
  24. Mayer A, Lahr G, Swaab D, Pilgrim C, Reisert I. The Y-chromosomal genes SRY and ZFY are transcribed in adult human brain. Neurogenetics. 1998;1:281-8 pubmed
    ..These genes are candidates for male-specific transcriptional regulators that could confer upon human brain cells the potential for hormone-independent realization and maintenance of genetic sex. ..
  25. Ulrich H, Jentsch S. Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair. EMBO J. 2000;19:3388-97 pubmed
    ..Surprisingly, UBC13 and MMS2 are largely cytosolic proteins, but DNA damage triggers their redistribution to the nucleus. These findings suggest a mechanism by which the activity of this DNA repair pathway could be regulated. ..
  26. Valentin M, Balvers M, Pusch W, Weinbauer G, Knudsen J, Ivell R. Structure and expression of the mouse gene encoding the endozepine-like peptide from haploid male germ cells. Eur J Biochem. 2000;267:5438-49 pubmed
    ..The ELP gene and its product thus offer an ideal system with which to investigate the differentiation of late haploid stages of spermatogenesis. ..
  27. Wingender E, Chen X, Fricke E, Geffers R, Hehl R, Liebich I, et al. The TRANSFAC system on gene expression regulation. Nucleic Acids Res. 2001;29:281-3 pubmed
    ..They are accompanied by a number of program routines for identifying potential transcription factor binding sites or for localizing individual components in the regulatory network of a cell. ..
  28. Stanelle J, Stiewe T, Theseling C, Peter M, Pützer B. Gene expression changes in response to E2F1 activation. Nucleic Acids Res. 2002;30:1859-67 pubmed
    ..These results provide new insight into the role of E2F1 in tumorigenesis as a basis for the development of novel anti-cancer therapeutics. ..
  29. Mertens P, Steinmann K, Alfonso Jaume M, En Nia A, Sun Y, Lovett D. Combinatorial interactions of p53, activating protein-2, and YB-1 with a single enhancer element regulate gelatinase A expression in neoplastic cells. J Biol Chem. 2002;277:24875-82 pubmed
  30. Pruteanu M, Hengge Aronis R. The cellular level of the recognition factor RssB is rate-limiting for sigmaS proteolysis: implications for RssB regulation and signal transduction in sigmaS turnover in Escherichia coli. Mol Microbiol. 2002;45:1701-13 pubmed
    ..e. phosphorylated RssB. ..
  31. Freude S, Hausmann J, Hofer M, Pham Mitchell N, Campbell I, Staeheli P, et al. Borna disease virus accelerates inflammation and disease associated with transgenic expression of interleukin-12 in the central nervous system. J Virol. 2002;76:12223-32 pubmed
    ..Our results illustrate that infection of the CNS with a virus that is benign in certain hosts can be harmful in such normally disease-resistant hosts if the tissue is unfavorably preconditioned by proinflammatory cytokines. ..
  32. Thomas D, Zhang W, Wu K, Wimmer A, Gut B, Wendt Nordahl G, et al. Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein. Cardiovasc Res. 2003;59:14-26 pubmed
    ..The molecular mechanisms of this PKC-dependent process are not completely understood but do not depend on direct PKC-dependent phosphorylation of the channel. ..
  33. Laccone F, Jünemann I, Whatley S, Morgan R, Butler R, Huppke P, et al. Large deletions of the MECP2 gene detected by gene dosage analysis in patients with Rett syndrome. Hum Mutat. 2004;23:234-44 pubmed
    ..We suggest that routine mutation screening in MECP2 should include quantitative analysis of the genomic sequences flanking the DPR. ..
  34. Kell C, Dehghani F, Wicht H, Molina C, Korf H, Stehle J. Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary. J Comp Neurol. 2004;478:379-94 pubmed
    ..Our data show that a basic ICER level is required by many cell systems and can be seen as an anticipatory and/or a protective measure in systems with superior reactive dynamics. ..
  35. Beyer M, Kochanek M, Darabi K, Popov A, Jensen M, Endl E, et al. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood. 2005;106:2018-25 pubmed
    ..In light of similar findings for cyclophosphamide the combination of fludarabine and cyclophosphamide might be further exploited in strategies reducing immunosuppression prior to cancer immunotherapy. ..
  36. Albrecht J, Müller Fleckenstein I, Schmidt M, Fleckenstein B, Biesinger B. Tyrosine phosphorylation of the Tio oncoprotein is essential for transformation of primary human T cells. J Virol. 2005;79:10507-13 pubmed
    ..The requirement for the tyrosine phosphorylation site at position 136 suggests a role for Tio beyond simple deregulation of the kinase. ..
  37. Kloting N, Wilke B, Kloting I. Triplet repeat in the Repin1 3'-untranslated region on rat chromosome 4 correlates with facets of the metabolic syndrome. Diabetes Metab Res Rev. 2007;23:406-10 pubmed
  38. Stubenrauch F, Straub E, Fertey J, Iftner T. The E8 repression domain can replace the E2 transactivation domain for growth inhibition of HeLa cells by papillomavirus E2 proteins. Int J Cancer. 2007;121:2284-92 pubmed
    ..In summary, our results demonstrate that the small E8 repression domain can functionally replace the large E2 transactivation domain for growth inhibition of HeLa cervical cancer cells. ..
  39. Schnetz K. Fine-tuned growth phase control of dps, encoding a DNA protection protein, by FIS and H-NS. Mol Microbiol. 2008;68:1345-7 pubmed publisher
    ..The finding suggests a simple mechanism of growth phase control of Dps production and has implications for the response to oxidative stress by pathogenic enterobacteria. ..
  40. Du T, Jellbauer S, Müller M, Schmid M, Niessing D, Jansen R. Nuclear transit of the RNA-binding protein She2 is required for translational control of localized ASH1 mRNA. EMBO Rep. 2008;9:781-7 pubmed publisher
    ..Our results indicate that the nucleolar transit of RNA-binding proteins such as She2 is necessary for the correct assembly of translationally silenced localizing messenger ribonucleoproteins. ..
  41. Kim J, Zaehres H, Wu G, Gentile L, Ko K, Sebastiano V, et al. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature. 2008;454:646-50 pubmed publisher
    ..We propose that, in inducing pluripotency, the number of reprogramming factors can be reduced when using somatic cells that endogenously express appropriate levels of complementing factors. ..
  42. Griese J, Witte G, Hopfner K. Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins. Nucleic Acids Res. 2010;38:3454-65 pubmed publisher
    ..The condensin hinge domain preferentially binds single-stranded DNA. We propose that this activity plays a role in the SSB repair function of the condensin complex. ..
  43. Kaufmann E, Paul H, Friedle H, Metz A, Scheucher M, Clement J, et al. Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1' in Xenopus laevis embryos. EMBO J. 1996;15:6739-49 pubmed
  44. Jumaa H, Guenet J, Nielsen P. Regulated expression and RNA processing of transcripts from the Srp20 splicing factor gene during the cell cycle. Mol Cell Biol. 1997;17:3116-24 pubmed
    ..These motifs may be functional since reporter constructs with the SRp20 promoter can be stimulated by cotransfection with E2F expression plasmids. ..
  45. Schneider A, Peukert K, Eilers M, Hanel F. Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc. Curr Top Microbiol Immunol. 1997;224:137-46 pubmed
    ..We have termed this protein Miz-1 (Myc-interacting zinc finger protein). Some of the properties of Miz-1 suggest that it may be involved in gene repression by Myc in vivo. ..
  46. Buchberger A, Arnold H. The MADS domain containing transcription factor cMef2a is expressed in heart and skeletal muscle during embryonic chick development. Dev Genes Evol. 1999;209:376-81 pubmed
    ..cMef2a expression in heart and skeletal muscle continues into adulthood when it is also seen in intestinal mesenchyme and in brain. ..
  47. Tuckermann J, Reichardt H, Arribas R, Richter K, Schutz G, Angel P. The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin. J Cell Biol. 1999;147:1365-70 pubmed
    ..Thus, these data suggest that the DNA binding-independent function of the GR is dispensable for repression of AP-1 activity in vivo and responsible for the antitumor promoting activity of GCs. ..
  48. Rose A, Meier I, Wienand U. The tomato I-box binding factor LeMYBI is a member of a novel class of myb-like proteins. Plant J. 1999;20:641-52 pubmed
    ..LeMYBI acts as a transcriptional activator in yeast and plants, and binds to the I-box with a DNA-binding domain located in the carboxyterminal domain. ..
  49. Rusch A, Ng L, Goodyear R, Oliver D, Lisoukov I, Vennstrom B, et al. Retardation of cochlear maturation and impaired hair cell function caused by deletion of all known thyroid hormone receptors. J Neurosci. 2001;21:9792-800 pubmed
    ..These results indicate that distinct pathways mediated by TRbeta alone or by TRbeta and TRalpha1 together facilitate control over an extended range of functions during the maturation of the cochlea...
  50. Quack M, Frank C, Carlberg C. Differential nuclear receptor signalling from DR4-type response elements. J Cell Biochem. 2002;86:601-12 pubmed
  51. Tauch A, Bischoff N, Brune I, Kalinowski J. Insights into the genetic organization of the Corynebacterium diphtheriae erythromycin resistance plasmid pNG2 deduced from its complete nucleotide sequence. Plasmid. 2003;49:63-74 pubmed
    ..The detailed annotation of the entire pNG2 sequence provided genetic information regarding its molecular evolution and its role in dissemination of antibiotic resistance genes by horizontal gene transfer...
  52. Bettendorf O, Heine B, Kneif S, Eltze E, Semjonow A, Herbst H, et al. Expression-patterns of the RNA component (hTR)and the catalytic subunit (hTERT) of human telomerase in nonneoplastic prostate tissue, prostatic intraepithelial neoplasia, and prostate cancer. Prostate. 2003;55:99-104 pubmed
    ..No association was observed between the grade of the tumour differentiation and semiquantitative levels of hTR- or hTERT-expression. Telomerase is of limited value for the diagnostic of malignant or benign lesions in prostate. ..
  53. Lakowski B, Eimer S, Göbel C, Böttcher A, Wagler B, Baumeister R. Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans. Development. 2003;130:2117-28 pubmed
  54. Quintanilla Martinez L, Kremer M, Specht K, Calzada Wack J, Nathrath M, Schaich R, et al. Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events. Am J Pathol. 2003;162:1449-61 pubmed
    ..0066). The universal expression of Mcl-1, independent of activated Stat 3, suggests that its expression is constitutive and that it might play an important role in the pathogenesis of MM. ..
  55. Schweyer S, Soruri A, Peters J, Wagner A, Radzun H, Fayyazi A. Malignant germ cell tumours of the testis express interferon-gamma, but are resistant to endogenous interferon-gamma. Br J Cancer. 2003;89:915-21 pubmed
  56. Buerger C, Groner B. Bifunctional recombinant proteins in cancer therapy: cell penetrating peptide aptamers as inhibitors of growth factor signaling. J Cancer Res Clin Oncol. 2003;129:669-75 pubmed
    ..The aptamer constructs can be supplemented with additional functional domains to enhance their inhibitory effects. ..
  57. Zhang S, Schlott B, Görlach M, Grosse F. DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. Nucleic Acids Res. 2004;32:1-10 pubmed
    ..These results support the view that DNA-PK can also function as an RNA-dependent protein kinase to regulate some aspects of RNA metabolism, such as RNA processing and transport. ..
  58. Xu G, Muller O, Stange E, Fuchs M. Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible mice. Biochim Biophys Acta. 2004;1688:274-9 pubmed
    ..This defect may contribute to cholesterol hypersecretion and gallstone formation. ..
  59. Chan Schaminet K, Baniwal S, Bublak D, Nover L, Scharf K. Specific interaction between tomato HsfA1 and HsfA2 creates hetero-oligomeric superactivator complexes for synergistic activation of heat stress gene expression. J Biol Chem. 2009;284:20848-57 pubmed publisher
    ..The results are summarized in a model of assembly and function of HsfA1/A2 superactivator complexes in hs gene regulation. ..
  60. Qian F, Kruse U, Lichter P, Sippel A. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. Genomics. 1995;28:66-73 pubmed
    ..3 in the order centromere-NFIX-NFIC-telomere. Comparison of the position of NFI genes and JUN genes revealed a close physical linkage between members of the NFI and JUN gene families in the human genome. ..
  61. Nebl G, Cato A. NFI/X proteins: a class of NFI family of transcription factors with positive and negative regulatory domains. Cell Mol Biol Res. 1995;41:85-95 pubmed
    ..With the identification of the negative domain in the NFI/X proteins, we demonstrate here a novel regulatory feature of these proteins in positive and negative modulation of gene expression. ..
  62. Hirsch E, Iglesias A, Potocnik A, Hartmann U, Fassler R. Impaired migration but not differentiation of haematopoietic stem cells in the absence of beta1 integrins. Nature. 1996;380:171-5 pubmed
    ..Our results indicate that haematopoietic stem cells lacking beta1 integrins can form and differentiate into different lineages but cannot colonize the fetal liver. ..
  63. Lee S, Boos W, Bouche J, Plumbridge J. Signal transduction between a membrane-bound transporter, PtsG, and a soluble transcription factor, Mlc, of Escherichia coli. EMBO J. 2000;19:5353-61 pubmed
    ..The control of Mlc activity by sequestration to a transport protein represents a novel form of signal transduction in gene regulation. ..
  64. Waelter S, Scherzinger E, Hasenbank R, Nordhoff E, Lurz R, Goehler H, et al. The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis. Hum Mol Genet. 2001;10:1807-17 pubmed
  65. Otto F, Lubbert M, Stock M. Upstream and downstream targets of RUNX proteins. J Cell Biochem. 2003;89:9-18 pubmed
    ..Whether a particular RUNX protein specifically targets a defined subset of downstream genes or whether there is some redundancy as to which RUNX protein activates which target promoter remains to be elucidated. ..
  66. Mika F, Hengge R. A two-component phosphotransfer network involving ArcB, ArcA, and RssB coordinates synthesis and proteolysis of sigmaS (RpoS) in E. coli. Genes Dev. 2005;19:2770-81 pubmed
    ..Moreover, this induction is enhanced by a positive feedback that involves sigma(S)-dependent induction of ArcA, which further reduces sigma(S) proteolysis, probably by competing with RssB for residual phosphorylation by ArcB. ..
  67. Hoeveler A, Doerfler W. Specific factors binding to the late E2A promoter region of adenovirus type 2 DNA: no apparent effects of 5'-CCGG-3' methylation. DNA. 1987;6:449-60 pubmed
  68. Althoefer H, Schleiffer A, Wassmann K, Nordheim A, Ammerer G. Mcm1 is required to coordinate G2-specific transcription in Saccharomyces cerevisiae. Mol Cell Biol. 1995;15:5917-28 pubmed
    ..However, constitutive CLB2 expression does not suppress the mitotic defect, and therefore other essential activities required for the G2-to-M transition must also depend on Mcm1 function. ..
  69. Schlensog V, Lutz S, Bock A. Purification and DNA-binding properties of FHLA, the transcriptional activator of the formate hydrogenlyase system from Escherichia coli. J Biol Chem. 1994;269:19590-6 pubmed
    ..Formate seems to have no effect on the DNA-binding properties of FHLA. The binding sites of FHLA were characterized by DNase I footprinting; sequence motifs putatively involved in the interaction with FHLA are described. ..
  70. Meier I, Phelan T, Gruissem W, Spiker S, Schneider D. MFP1, a novel plant filament-like protein with affinity for matrix attachment region DNA. Plant Cell. 1996;8:2105-15 pubmed
    ..Its structure, MAR DNA binding activity, and nuclear matrix localization suggest that MFP1 is likely to participate in nuclear architecture by connecting chromatin with the nuclear matrix and potentially with the nuclear envelope. ..
  71. Wrehlke C, Schmitt Wrede H, Qiao Z, Wunderlich F. Enhanced expression in spleen macrophages of the mouse homolog to the human putative tumor suppressor gene ZFM1. DNA Cell Biol. 1997;16:761-7 pubmed
    ..The different MZFM-isoforms may be part of a macrophage-inherent program of transduction of environmental signals into different activational states of macrophages. ..
  72. Vogel T, Schmidtke J. Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein". Cytogenet Cell Genet. 1998;80:209-13 pubmed
    ..The TSPY family forms part of a superfamily, TTSN, with autosomal representatives, highly conserved in mammals and beyond. ..
  73. Sattlegger E, Hinnebusch A, Barthelmess I. cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2alpha kinase and histidyl-tRNA synthetase-related domains required for general amino acid control. J Biol Chem. 1998;273:20404-16 pubmed
    ..These findings suggest that cpc-3 is the functional homologue of GCN2, being required for increased translation of cpc-1 mRNA in amino acid-starved cells. ..
  74. Ellinghaus P, Wolfrum C, Assmann G, Spener F, Seedorf U. Phytanic acid activates the peroxisome proliferator-activated receptor alpha (PPARalpha) in sterol carrier protein 2-/ sterol carrier protein x-deficient mice. J Biol Chem. 1999;274:2766-72 pubmed
    ..We conclude that phytanic acid can be considered as a bona fide physiological ligand of murine PPARalpha. ..
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