Experts and Doctors on dihydropteroate synthase in Sweden


Locale: Sweden
Topic: dihydropteroate synthase

Top Publications

  1. Jonsson M, Swedberg G. Hydroxymethyldihydropterin pyrophosphokinase from Plasmodium falciparum complements a folK-knockout mutant in E. coli when expressed as a separate polypeptide detached from dihydropteroate synthase. Mol Biochem Parasitol. 2005;140:123-5 pubmed
  2. Radstrom P, Fermer C, Kristiansen B, Jenkins A, Skold O, Swedberg G. Transformational exchanges in the dihydropteroate synthase gene of Neisseria meningitidis: a novel mechanism for acquisition of sulfonamide resistance. J Bacteriol. 1992;174:6386-93 pubmed
    ..The origin of the resistance-mediating segment of the gene is unknown, but hybridization results showed the presence of homologous dhps genes in Neisseria gonorrhoeae and N. lactamica but not in N. subflava or Branhamella catarrhalis. ..
  3. Fermer C, Kristiansen B, Skold O, Swedberg G. Sulfonamide resistance in Neisseria meningitidis as defined by site-directed mutagenesis could have its origin in other species. J Bacteriol. 1995;177:4669-75 pubmed
    ..This observation supports the idea of an interspecies transfer of genetic material in Neisseria species as a mechanism for the development of chromosomally mediated resistance. ..
  4. Swedberg G, Fermer C, Skold O. Point mutations in the dihydropteroate synthase gene causing sulfonamide resistance. Adv Exp Med Biol. 1993;338:555-8 pubmed
  5. Swedberg G, Ringertz S, Sk ld O. Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomal dihydropteroate synthase. Antimicrob Agents Chemother. 1998;42:1062-7 pubmed
    ..Kinetic measurements established different affinities for sulfathiazole for DHPS enzymes isolated from resistant and susceptible strains...
  6. Qvarnstr m Y, Swedberg G. Sulphonamide resistant commensal Neisseria with alterations in the dihydropteroate synthase can be isolated from carriers not exposed to sulphonamides. BMC Microbiol. 2002;2:34 pubmed
    ..meningitidis. Sulphonamide resistant commensal Neisseria were isolated from an environment not exposed to sulphonamides, suggesting that resistant Neisseria has become a natural part of the commensal throat flora...