Genomes and Genes
Experts and Doctors on differentiation antigens in United States
Locale: United States
Topic: differentiation antigens
- Talbott J, Loy D, Liu Y, Qiu M, Bunge M, Rao M, et al. Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes. Exp Neurol. 2005;192:11-24 pubmed..In vivo electrophysiology demonstrated a limited and unsustained functional recovery concurrent with endogenous remyelination following EB-induced lesions. ..
- Mandal P, Novotny M, Hamilton T. Lipopolysaccharide induces formyl peptide receptor 1 gene expression in macrophages and neutrophils via transcriptional and posttranscriptional mechanisms. J Immunol. 2005;175:6085-91 pubmed
- Baracskay K, Kidd G, Miller R, Trapp B. NG2-positive cells generate A2B5-positive oligodendrocyte precursor cells. Glia. 2007;55:1001-10 pubmed..NG2(+) cells appear prior to the expression of A2B5(+) cells and generate A2B5(+) cells. We propose that during development NG2(+)/A2B5(-) cells (pre-OPCs) represent the direct ancestor to A2B5(+) O2A progenitor cells (OPCs). ..
- Klassen H, Ziaeian B, Kirov I, Young M, Schwartz P. Isolation of retinal progenitor cells from post-mortem human tissue and comparison with autologous brain progenitors. J Neurosci Res. 2004;77:334-43 pubmed..hRPCs can be distinguished from hBPC cultures by the expression of retinal specification genes and recoverin. ..
- Shah N, Marchionni M, Isaacs I, Stroobant P, Anderson D. Glial growth factor restricts mammalian neural crest stem cells to a glial fate. Cell. 1994;77:349-60 pubmed..Taken together with the expression pattern of GGF, these data suggest a lateral signaling model for the diversification of cell types within developing peripheral ganglia. ..
- Mazhawidza W, Winters S, Kaiser U, Kakar S. Identification of gene networks modulated by activin in LbetaT2 cells using DNA microarray analysis. Histol Histopathol. 2006;21:167-78 pubmed publisher..Modulation of expression of genes by activin suggests that activin may mediate its effects through a variety of signaling pathways. ..
- Back S, Luo N, Borenstein N, Levine J, Volpe J, Kinney H. Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury. J Neurosci. 2001;21:1302-12 pubmed
- Gorski J, Liu F, Artigues A, Castagna L, Osdoby P. New alternatively spliced form of galectin-3, a member of the beta-galactoside-binding animal lectin family, contains a predicted transmembrane-spanning domain and a leucine zipper motif. J Biol Chem. 2002;277:18840-8 pubmed..Gal-3TM1 is the first example of a galectin superfamily member capable of being expressed as a soluble protein and as a transmembrane protein. ..
- Offner H. Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis. J Neurosci Res. 2004;78:603-24 pubmed..Alternatively, one might envision using EE or fluasterone metabolites alone or in combination therapies in both male and female MS patients. ..
- Taglauer E, Yankee T, Petroff M. Maternal PD-1 regulates accumulation of fetal antigen-specific CD8+ T cells in pregnancy. J Reprod Immunol. 2009;80:12-21 pubmed publisher..These results suggest that PD-1 plays a previously unrecognized role in maternal-fetal tolerance by inducing apoptosis of paternal antigen-specific T cells during pregnancy, thereby controlling their abundance. ..
- Siegall C, Haggerty H, Warner G, Chace D, Mixan B, Linsley P, et al. Prevention of immunotoxin-induced immunogenicity by coadministration with CTLA4Ig enhances antitumor efficacy. J Immunol. 1997;159:5168-73 pubmed..These data show that cotreatment of immunotoxins with CTLA4Ig, by inhibiting the production of anti-immunotoxin Abs, can extend the duration of BR96 sFv-PE40 therapy to give greater exposure, reduced toxicities, and increased efficacy. ..
- Linsley P, Ledbetter J. The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol. 1993;11:191-212 pubmed..The CD28 costimulatory receptor represents a novel target for immunosuppressive drugs. ..
- Dietrich J, Blumberg B, Roshal M, Baker J, Hurley S, Mayer Proschel M, et al. Infection with an endemic human herpesvirus disrupts critical glial precursor cell properties. J Neurosci. 2004;24:4875-83 pubmed
- West F, Machacek D, Boyd N, Pandiyan K, Robbins K, Stice S. Enrichment and differentiation of human germ-like cells mediated by feeder cells and basic fibroblast growth factor signaling. Stem Cells. 2008;26:2768-76 pubmed publisher..Disclosure of potential conflicts of interest is found at the end of this article. ..
- Edelmann K, Wilson C. Role of CD28/CD80-86 and CD40/CD154 costimulatory interactions in host defense to primary herpes simplex virus infection. J Virol. 2001;75:612-21 pubmed
- Covert M, Leung T, Gaston J, Baltimore D. Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science. 2005;309:1854-7 pubmed..The MyD88-independent pathway required Inferon regulatory factor 3-dependent expression of TNFalpha to activate NF-kappaB, and the time required for TNFalpha synthesis established the delay. ..
- Leung H, Bradshaw J, Cleaveland J, Linsley P. Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail. J Biol Chem. 1995;270:25107-14 pubmed..Thus, the subcellular localization of CTLA-4 is controlled by a tyrosine-containing motif within its cytoplasmic domain. Contained within this motif is a binding site for SH2 domains of the p85 subunit of phosphatidylinositol 3-kinase. ..
- de Toledo F, Cheng J, Dousa T. Retinoic acid and triiodothyronine stimulate ADP-ribosyl cyclase activity in rat vascular smooth muscle cells. Biochem Biophys Res Commun. 1997;238:847-50 pubmed
- May K, Roychowdhury S, Bhatt D, Kocak E, Bai X, Liu J, et al. Anti-human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies. Blood. 2005;105:1114-20 pubmed..These data validate the development of additional screening tools, such as the one described, to further characterize functional activity of antihuman antibodies before proceeding with clinical translation to human studies. ..
- van de Winkel J, Ernst L, Anderson C, Chiu I. Gene organization of the human high affinity receptor for IgG, Fc gamma RI (CD64). Characterization and evidence for a second gene. J Biol Chem. 1991;266:13449-55 pubmed..This observation suggests the existence of a second hFc gamma RI gene which lacks one of the two internal HindIII sites rather than a restriction fragment length polymorphism. ..
- Thiaville M, Pan Y, Gjymishka A, Zhong C, Kaufman R, Kilberg M. MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. J Biol Chem. 2008;283:10848-57 pubmed publisher..Collectively, these results document a critical interdependence between the MEK-ERK MAPK signaling pathway and the amino acid stress-activated pathway. ..
- Johnson A, Heinzel F, Diaconu E, Sun Y, Hise A, Golenbock D, et al. Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation. Invest Ophthalmol Vis Sci. 2005;46:589-95 pubmed..This pathway is therefore likely to have an important role in the early events leading to microbial keratitis. ..
- Mamidipudi V, Li X, Wooten M. Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-kappa B. J Biol Chem. 2002;277:28010-8 pubmed..Altogether, our data provide novel information regarding the proximal components involved in p75 receptor signaling and underscore the importance of the atypical PKC interacting protein p62 in this process. ..
- Shao W, Lazaryan A, Dorak M, Penman Aguilar A, Wilson C, Margolick J, et al. Cohort- and time-specific associations of CTLA4 genotypes with HIV-1 disease progression. AIDS. 2006;20:1583-90 pubmed..Further analyses in conjunction with other biologically and positionally related genes, such as CD28 and ICOS, may help explain the disparate findings. ..
- Yusufi A, Cheng J, Thompson M, Dousa T, Warner G, Walker H, et al. cADP-ribose/ryanodine channel/Ca2+-release signal transduction pathway in mesangial cells. Am J Physiol Renal Physiol. 2001;281:F91-F102 pubmed..We conclude that MC possess elements of a novel ADP-ribosyl cyclase-->cADPR-->RyR-->Ca2+-release signaling pathway subject to regulation by proinflammatory cytokines and steroid superfamily hormones...
- Dillon T, Carey K, Wetzel S, Parker D, Stork P. Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4. Mol Cell Biol. 2005;25:4117-28 pubmed..We demonstrate that CTLA-4 activates Rap1, and we propose that intracellular signals from CTLA-4 antagonize CD28, at least in part, at the level of Rap1. ..
- Heinzel F, Maier R. Interleukin-4-independent acceleration of cutaneous leishmaniasis in susceptible BALB/c mice following treatment with anti-CTLA4 antibody. Infect Immun. 1999;67:6454-60 pubmed..We conclude that CTLA4 significantly modulates Th2 development in murine leishmaniasis and that the Th2-polarizing effects of anti-CTLA4 treatment result in IL-4-independent exacerbation of disease. ..
- Prell R, Evans D, Thalhofer C, Shi T, Funatake C, Weinberg A. OX40-mediated memory T cell generation is TNF receptor-associated factor 2 dependent. J Immunol. 2003;171:5997-6005 pubmed..The data provide evidence that TRAF2 is linked to OX40-mediated memory T cell expansion and survival, and point to the down-regulation of CTLA-4 as a possible control element to enhance early T cell expansion through OX40 signaling. ..
- Cathcart H, FIELDS M, Zheng M, Marshall B, Atherton S. Infiltrating cells and IFNgamma production in the injected eye after uniocular anterior chamber inoculation of HSV-1. Invest Ophthalmol Vis Sci. 2009;50:2269-75 pubmed publisher..The purpose of this study was to identify early infiltrating cells and to determine whether infiltrating cells produce interferon (IFN)gamma...
- Hua F, Ha T, Ma J, Gao X, Kelley J, Williams D, et al. Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts. Biochem Biophys Res Commun. 2005;338:1118-25 pubmed..The results demonstrate that both inhibition of the NFkappaB activation pathway and activation of the Akt signaling pathway may be responsible for the protective effect of transfection of dominant negative MyD88. ..
- Nearman Z, Wlodarski M, Jankowska A, Howe E, Narvaez Y, Ball E, et al. Immunogenetic factors determining the evolution of T-cell large granular lymphocyte leukaemia and associated cytopenias. Br J Haematol. 2007;136:237-48 pubmed..03 and 0.01 respectively); the biological relevance of this finding is questionable. The significance of additional genetic polymorphisms and their clinical correlation to evolution of T-LGL requires future analysis...
- Jiang W, Jiang C, Pei H, Wang L, Zhang J, Hu H, et al. In vivo molecular mediators of cancer growth suppression and apoptosis by selenium in mammary and prostate models: lack of involvement of gadd genes. Mol Cancer Ther. 2009;8:682-91 pubmed publisher..They cast doubt on the three gadd genes as mediators of Se action in vivo. ..
- Hurwitz A, Sullivan T, Sobel R, Allison J. Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice. Proc Natl Acad Sci U S A. 2002;99:3013-7 pubmed
- Adler H, Chinery R, Wu D, Kussick S, Payne J, Fornace A, et al. Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins. Mol Cell Biol. 1999;19:7050-60 pubmed..We propose that the role of HRX fusion proteins as negative regulators of post-DNA-damage-induced apoptosis is important to leukemia progression. ..
- Yadav D, Hill N, Yagita H, Azuma M, Sarvetnick N. Altered availability of PD-1/PD ligands is associated with the failure to control autoimmunity in NOD mice. Cell Immunol. 2009;258:161-71 pubmed publisher..In summary, these data suggest that diabetes susceptibility in NOD mice is associated with altered PD-1/PD-L availability. ..
- Koguchi Y, Thauland T, Slifka M, Parker D. Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4+ T cells and is quickly expressed on the cell surface in an antigen-specific manner. Blood. 2007;110:2520-7 pubmed..We suggest that delivery of preformed CD40L to antigen-presenting cells (APCs) could enable antigen-specific activation of APCs in transient interactions that are too brief to permit de novo synthesis of CD40L. ..
- Zhang J, Harrison J, Studzinski G. Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D?. Exp Cell Res. 2011;317:117-30 pubmed publisher..This activation may result from the removal of feedback inhibition of an upstream regulator of those pathways, when p38MAPK alpha and beta are inhibited by SB. ..
- Mitsuhashi M. Ex vivo simulation of leukocyte function: stimulation of specific subset of leukocytes in whole blood followed by the measurement of function-associated mRNAs. J Immunol Methods. 2010;363:95-100 pubmed publisher..The method introduced in this study will be a new paradigm for clinical cellular immunology. ..
- Tabibzadeh S. Evidence of T-cell activation and potential cytokine action in human endometrium. J Clin Endocrinol Metab. 1990;71:645-9 pubmed..Evidence for activation of T-cells and expression of interferon-gamma receptor in human endometrial epithelium suggests that endometrium may be an active site for cytokine action. ..
- Peach R, Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, et al. Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28. J Biol Chem. 1995;270:21181-7 pubmed..Thus, full CTLA4Ig and CD28Ig binding to B7 molecules is dependent upon residues in the GFC'C" face of the IgV domain and the ABED face of the IgC domain. ..
- Khan I, Matsuura T, Kasper L. Activation-mediated CD4+ T cell unresponsiveness during acute Toxoplasma gondii infection in mice. Int Immunol. 1996;8:887-96 pubmed..gondii infection in mice, and may be important in immune down-regulation and parasite persistence in the infected host. ..
- Prevot V, Cornea A, Mungenast A, Smiley G, Ojeda S. Activation of erbB-1 signaling in tanycytes of the median eminence stimulates transforming growth factor beta1 release via prostaglandin E2 production and induces cell plasticity. J Neurosci. 2003;23:10622-32 pubmed
- Yee L, Perez K, Tang J, van Leeuwen D, Kaslow R. Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection. J Infect Dis. 2003;187:1264-71 pubmed..0095) and the -318C-49G haplotype. CTLA4 49G in exon 1 alone and in a haplotype with -318C promoter is associated with sustained IFNalpha+R response in white patients with HCV genotype 1 infection. ..
- Khattri R, Cox T, Yasayko S, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol. 2003;4:337-42 pubmed..The forced expression of Foxp3 also delays disease in CTLA-4-/- mice, indicating that the Scurfin and CTLA-4 pathways may intersect and providing further insight into the T(R) cell lineage. ..
- Pioli P, Amiel E, Schaefer T, Connolly J, Wira C, Guyre P. Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract. Infect Immun. 2004;72:5799-806 pubmed..These data suggest that TLRs are differentially expressed in distinct compartments of the female reproductive tract and may provide insight regarding the regulation of inflammation and immunity within the tract...
- Odden J, Holbrook S, Doe C. Drosophila HB9 is expressed in a subset of motoneurons and interneurons, where it regulates gene expression and axon pathfinding. J Neurosci. 2002;22:9143-9 pubmed..Thus, Drosophila HB9 is required in a subset of motoneurons and interneurons for establishing proper axon projections but does not have a general role in distinguishing motoneuron and interneuron cell types. ..
- Bai X, Liu J, May K, Guo Y, Zheng P, Liu Y. B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo. Blood. 2002;99:2880-9 pubmed..In contrast, B7-CTLA4 interaction enhances the CTL-mediated destruction of tumors, but not T-cell clonal expansion. ..
- Bieber A, Warrington A, Asakura K, Ciric B, Kaveri S, Pease L, et al. Human antibodies accelerate the rate of remyelination following lysolecithin-induced demyelination in mice. Glia. 2002;37:241-9 pubmed..We propose the use of human polyclonal IgM or specific human monoclonal IgM antibodies as potential therapies to enhance myelin repair following CNS injury and disease...
- Ernst L, van de Winkel J, Chiu I, Anderson C. Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. J Biol Chem. 1992;267:15692-700 pubmed..Two transcripts, from genes B and C, have stop codons in EC3 and would be predicted to generate secreted receptors. ..
- Tabibzadeh S. Proliferative activity of lymphoid cells in human endometrium throughout the menstrual cycle. J Clin Endocrinol Metab. 1990;70:437-43 pubmed..The findings suggest that in situ proliferation is one mechanism by which the endometrial lymphoid cell pool within endometrium is restored after each menstrual shedding. ..
- Williams J, Oh S, Jorgensen M, Steiger N, Darwiche H, Shupe T, et al. The role of the Wnt family of secreted proteins in rat oval "stem" cell-based liver regeneration: Wnt1 drives differentiation. Am J Pathol. 2010;176:2732-42 pubmed publisher..Furthermore, changes in Wnt1 levels are required for the efficient regeneration of the liver by oval cells during massive hepatic injury...
- Reding S, Stepnoski A, Cloninger E, Oatley J. THY1 is a conserved marker of undifferentiated spermatogonia in the pre-pubertal bull testis. Reproduction. 2010;139:893-903 pubmed publisher..Collectively, these results demonstrate that THY1 is a marker of undifferentiated spermatogonia in testes of pre-pubertal bulls, and isolation of THY1+ cells results in their enrichment from the total testis cell population. ..
- Kretz K, Katze J, Trewyn R. Guanine analog-induced differentiation of human promyelocytic leukemia cells and changes in queuine modification of tRNA. Mol Cell Biol. 1987;7:3613-9 pubmed..The data suggest a primary role for the change in queuine modification of tRNA in mediating the differentiation of HGPRT-deficient HL-60 cells induced by guanine analogs...
- Bannerman D, Tupper J, Erwert R, Winn R, Harlan J. Divergence of bacterial lipopolysaccharide pro-apoptotic signaling downstream of IRAK-1. J Biol Chem. 2002;277:8048-53 pubmed
- Qin J, Qian Y, Yao J, Grace C, Li X. SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. J Biol Chem. 2005;280:25233-41 pubmed..These results indicate that SIGIRR inhibits IL-1 and LPS signaling pathways through differential mechanisms. ..
- Terada N, Baracskay K, Kinter M, Melrose S, Brophy P, Boucheix C, et al. The tetraspanin protein, CD9, is expressed by progenitor cells committed to oligodendrogenesis and is linked to beta1 integrin, CD81, and Tspan-2. Glia. 2002;40:350-9 pubmed..These data support the hypothesis that CD9 helps form the tetraspanin web beneath the plasma membranes of progenitor cells committed to oligodendrogenesis, but that CD9 is not essential for oligodendrogenesis and myelination. ..
- Eliseev R, Zuscik M, Schwarz E, O Keefe R, Drissi H, Rosier R. Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. J Cell Biochem. 2005;96:1262-73 pubmed..Our study brings new insight into the mechanisms underlying radiation-induced apoptosis of osteosarcoma, and may lead to development of new therapeutic strategies against osteosarcoma. ..
- Karcavich R, Doe C. Drosophila neuroblast 7-3 cell lineage: a model system for studying programmed cell death, Notch/Numb signaling, and sequential specification of ganglion mother cell identity. J Comp Neurol. 2005;481:240-51 pubmed..Our results confirm and extend previous work on the early portion of the NB7-3 lineage (Novotny et al.  Development 129:1027-1036; Lundell et al. [ 2003] Development 130:4109-4121). ..
- Datta S, Novotny M, Li X, Tebo J, Hamilton T. Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA. J Immunol. 2004;173:2755-61 pubmed..Hence the ability of TIRs to signal stabilization of mRNA appears to be linked to the MyD88-dependent signaling pathway. ..
- Thorp E, Gallagher T. Requirements for CEACAMs and cholesterol during murine coronavirus cell entry. J Virol. 2004;78:2682-92 pubmed..We conclude that cholesterol is an essential membrane fusion cofactor that can act with or without CEACAMs to promote MHV entry. ..
- Fernandez S, Jose P, Avdiushko M, Kaplan A, Cohen D. Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists. J Immunol. 2004;172:2613-20 pubmed..These findings demonstrate a novel regulatory mechanism that may allow AM to overcome inhibitory effects of constitutive IL-10 in the lungs that may permit a more effective response to pulmonary infections. ..
- Pillai M, Hayes B, Torok Storb B. Inducible transgenes under the control of the hCD68 promoter identifies mouse macrophages with a distribution that differs from the F4/80 - and CSF-1R-expressing populations. Exp Hematol. 2009;37:1387-92 pubmed publisher..Whether this population is functionally distinct remains to be established. ..
- Mathias J, Dodd M, Walters K, Yoo S, Ranheim E, Huttenlocher A. Characterization of zebrafish larval inflammatory macrophages. Dev Comp Immunol. 2009;33:1212-7 pubmed publisher..These findings identify distinct functional and morphological characteristics of inflammatory macrophages in zebrafish larvae. ..
- Liu B, Dai J, Zheng H, Stoilova D, Sun S, Li Z. Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases. Proc Natl Acad Sci U S A. 2003;100:15824-9 pubmed..Our study not only established the proinflammatory property of cell surface gp96 in vivo, but also suggested a chronic stimulation of DCs by gp96 as a pathway to initiate spontaneous autoimmune diseases. ..
- Ortega M, Pecaut M, Gridley D, Stodieck L, Ferguson V, Chapes S. Shifts in bone marrow cell phenotypes caused by spaceflight. J Appl Physiol (1985). 2009;106:548-55 pubmed publisher..However, the reduction in less differentiated cells may forebode future consequences for macrophage production and host defenses. This is of particular importance to considerations of future long-term spaceflights. ..
- Hayflick J, Stine J, Fox R, Hoekstra D, Gallatin W. Functional mapping of the cytoplasmic region of intercellular adhesion molecule-3 reveals important roles for serine residues. J Biol Chem. 1997;272:22207-14 pubmed..This study delineates separable regions and amino acid residues within the cytoplasmic portion of ICAM-3 that are important for T cell function. ..
- Steitz S, Speer M, Curinga G, Yang H, Haynes P, Aebersold R, et al. Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res. 2001;89:1147-54 pubmed..The findings suggest a positive role for SMCs in promoting vascular calcification. ..
- Davies M, Eubanks J, Powers M. Microglia and macrophages are increased in response to ischemia-induced retinopathy in the mouse retina. Mol Vis. 2006;12:467-77 pubmed..The temporal and spatial localization of MG/MAC adjacent to neovascular tufts suggests these cells are modulating the retinal response to ischemia-induced retinopathy. ..
- Chen C, Huang H, Ward C, Su J, Schaeffer L, Guo M, et al. A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila. Science. 2007;316:597-600 pubmed..These selfish elements use microRNA-mediated silencing of a maternally expressed gene essential for embryogenesis, which is coupled with early zygotic expression of a rescuing transgene. ..
- Van der Vieren M, Le Trong H, Wood C, Moore P, St John T, Staunton D, et al. A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3. Immunity. 1995;3:683-90 pubmed..The alpha d/CD18 molecule exhibits preferential recognition of ICAM-3 over ICAM-1. ..
- Peach R, Bajorath J, Brady W, Leytze G, Greene J, Naemura J, et al. Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1. J Exp Med. 1994;180:2049-58 pubmed..Thus, the MYPPPY motifs of CTLA4Ig and CD28Ig are important for their binding to B7-1, but the increased strength of this binding by CTLA4Ig is mediated by nonconserved residues in the CDR1- and CDR3-analogous regions. ..
- Marron M, Raffel L, Garchon H, Jacob C, Serrano Rios M, Martinez Larrad M, et al. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Hum Mol Genet. 1997;6:1275-82 pubmed..002) and the Korean population (P = 0.03). These results suggest that a true IDDM susceptibility locus (designated IDDM12) is located near CTLA4. ..
- Lute K, May K, Lu P, Zhang H, Kocak E, Mosinger B, et al. Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies. Blood. 2005;106:3127-33 pubmed..These results demonstrate that autoimmune disease does not quantitatively correlate with cancer immunity. Our approach may be generally applicable to the development of human therapeutic antibodies. ..
- Evans D, Prell R, Thalhofer C, Hurwitz A, Weinberg A. Engagement of OX40 enhances antigen-specific CD4(+) T cell mobilization/memory development and humoral immunity: comparison of alphaOX-40 with alphaCTLA-4. J Immunol. 2001;167:6804-11 pubmed..These studies demonstrate that OX40 engagement early after immunization with soluble Ag enhances long-term T cell and humoral immunity in a manner distinct from that provided by blocking CTLA-4. ..
- Fife B, Griffin M, Abbas A, Locksley R, Bluestone J. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest. 2006;116:2252-61 pubmed
- Wu D, Tkachuck D, Roberson R, Schubach W. The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity. J Biol Chem. 2002;277:27706-15 pubmed..These results implicate hSNF5/INI1 in the function of GADD34 and suggest that hSNF5/INI1 may regulate PP1 activity in vivo. ..