Experts and Doctors on developmental gene expression regulation in Switzerland


Locale: Switzerland
Topic: developmental gene expression regulation

Top Publications

  1. Zhu B, Zheng Y, Angliker H, Schwarz S, Thiry S, Siegmann M, et al. 5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence. Nucleic Acids Res. 2000;28:4157-65 pubmed
    ..In situ hybridization with antisense RNA indicate that MBD4 is only located in dividing cells of differentiating embryonic tissues. ..
  2. Urwyler S, Vassella E, Van den Abbeele J, Renggli C, Blundell P, Barry J, et al. Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei. PLoS Pathog. 2005;1:e22 pubmed
    ..The finding that this life cycle stage is usually negative for procyclin as well is new, and means that the paradigm will need to be revised...
  3. Schneitz K, Baker S, Gasser C, Redweik A. Pattern formation and growth during floral organogenesis: HUELLENLOS and AINTEGUMENTA are required for the formation of the proximal region of the ovule primordium in Arabidopsis thaliana. Development. 1998;125:2555-63 pubmed
    ..Furthermore, we show that HUELLENLOS also regulates the initiation and/or maintenance of integument and embryo sac ontogenesis and interestingly prevents inappropriate cell death in the young ovule. ..
  4. Zetka M, Kawasaki I, Strome S, Muller F. Synapsis and chiasma formation in Caenorhabditis elegans require HIM-3, a meiotic chromosome core component that functions in chromosome segregation. Genes Dev. 1999;13:2258-70 pubmed
  5. Muller B, Hartmann B, Pyrowolakis G, Affolter M, Basler K. Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell. 2003;113:221-33 pubmed
    ..Together, our results provide the molecular framework for a mechanism by which the extracellular Dpp/BMP morphogen establishes a finely tuned, graded read-out of transcriptional repression. ..
  6. Erb M, Flueck B, Kern F, Erne B, Steck A, Schaeren Wiemers N. Unraveling the differential expression of the two isoforms of myelin-associated glycoprotein in a mouse expressing GFP-tagged S-MAG specifically regulated and targeted into the different myelin compartments. Mol Cell Neurosci. 2006;31:613-27 pubmed
    ..In summary, our data provide new insight in the subcellular distribution of the two isoforms fundamental for the understanding of their specific functions in myelin formation and maintenance. ..
  7. Afouda A, Reynaud Deonauth S, Mohun T, Spohr G. Localized XId3 mRNA activation in Xenopus embryos by cytoplasmic polyadenylation. Mech Dev. 1999;88:15-31 pubmed
    ..The asymmetric polyadenylation may be important for establishing a prepattern of transcriptional regulators. ..
  8. Lichtneckert R, Bello B, Reichert H. Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster. Development. 2007;134:1291-300 pubmed
  9. Michos O, Gonçalves A, Lopez Rios J, Tiecke E, Naillat F, Beier K, et al. Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Development. 2007;134:2397-405 pubmed

More Information

Publications119 found, 100 shown here

  1. Roulet E, Armentero M, Krey G, Corthesy B, Dreyer C, Mermod N, et al. Regulation of the DNA-binding and transcriptional activities of Xenopus laevis NFI-X by a novel C-terminal domain. Mol Cell Biol. 1995;15:5552-62 pubmed
    ..Moreover, the region comprising the repressor domain participates in transactivation. Mechanisms that may allow the relief of DNA-binding inhibition in vivo and trigger transcriptional activation are discussed. ..
  2. Kondo T, Zakany J, Duboule D. Control of colinearity in AbdB genes of the mouse HoxD complex. Mol Cell. 1998;1:289-300 pubmed
  3. Xue L, Li X, Noll M. Multiple protein functions of paired in Drosophila development and their conservation in the Gooseberry and Pax3 homologs. Development. 2001;128:395-405 pubmed
  4. Sprecher S, Urbach R, Technau G, Rijli F, Reichert H, Hirth F. The columnar gene vnd is required for tritocerebral neuromere formation during embryonic brain development of Drosophila. Development. 2006;133:4331-9 pubmed
    ..Taken together, our results indicate that vnd is required for the genesis and proper identity specification of tritocerebral neural lineages during embryonic brain development of Drosophila. ..
  5. Hirth F, Loop T, Egger B, Miller D, Kaufman T, Reichert H. Functional equivalence of Hox gene products in the specification of the tritocerebrum during embryonic brain development of Drosophila. Development. 2001;128:4781-8 pubmed
    ..This suggests that in embryonic brain development, differences in Hox gene action rely mainly on cis-acting regulatory elements and not on Hox protein specificity. ..
  6. Reichert H, Bello B. Hox genes and brain development in Drosophila. Adv Exp Med Biol. 2010;689:145-53 pubmed
    ..Many features of Hox gene action in Drosophila brain development are evolutionarily conserved and are manifest in brain development of vertebrates. ..
  7. Seipel K, Schmid V. Evolution of striated muscle: jellyfish and the origin of triploblasty. Dev Biol. 2005;282:14-26 pubmed
    ..We argue for a motile tri-layered cnidarian ancestor and a monophyletic descent of striated muscle in Cnidaria and Bilateria. As a consequence, diploblasty evolved secondarily in cnidarian larvae and polyps. ..
  8. Fu W, Noll M. The Pax2 homolog sparkling is required for development of cone and pigment cells in the Drosophila eye. Genes Dev. 1997;11:2066-78 pubmed
    ..Spa expression is further required for activation of cut in cone cells and of the Bar locus in primary pigment cells. We suggest close functional analogies between Spa and Pax2 in the development of the insect and vertebrate eye. ..
  9. Frank M, Schaeren Wiemers N, Schneider R, Schwab M. Developmental expression pattern of the myelin proteolipid MAL indicates different functions of MAL for immature Schwann cells and in a late step of CNS myelinogenesis. J Neurochem. 1999;73:587-97 pubmed
    ..2) The early expression of MAL protein in immature Schwann cells suggests an important role of MAL in the terminal differentiation step of the Schwann cell lineage and in the onset of peripheral myelination. ..
  10. Stuurman J, Jäggi F, Kuhlemeier C. Shoot meristem maintenance is controlled by a GRAS-gene mediated signal from differentiating cells. Genes Dev. 2002;16:2213-8 pubmed
    ..This reveals a novel mechanism by which signals from differentiating tissues extrinsically control stem cell fate in the shoot apex. ..
  11. Müller R, Hülsmeier A, Altmann F, Ten Hagen K, Tiemeyer M, Hennet T. Characterization of mucin-type core-1 beta1-3 galactosyltransferase homologous enzymes in Drosophila melanogaster. FEBS J. 2005;272:4295-305 pubmed
    ..melanogaster suggests an increased complexity of core-1 O-glycan expression, which is possibly related to multiple developmental and physiological functions attributable to this class of glycans. ..
  12. Steullet P, Cabungcal J, Kulak A, Kraftsik R, Chen Y, Dalton T, et al. Redox dysregulation affects the ventral but not dorsal hippocampus: impairment of parvalbumin neurons, gamma oscillations, and related behaviors. J Neurosci. 2010;30:2547-58 pubmed publisher
    ..Thus, a GSH deficit affects PV-IR interneuron's integrity and neuronal synchrony in a region- and time-specific manner, leading to behavioral phenotypes related to psychiatric disorders. ..
  13. Cosio C, Dunand C. Transcriptome analysis of various flower and silique development stages indicates a set of class III peroxidase genes potentially involved in pod shattering in Arabidopsis thaliana. BMC Genomics. 2010;11:528 pubmed publisher
    ..The approach used in this study highlights key individual genes that merit further investigation. ..
  14. Labuhn M, Brack C. Age-related changes in the mRNA expression of actin isoforms in Drosophila melanogaster. Gerontology. 1997;43:261-7 pubmed
    ..The two cytoskeletal actin genes show little changes in their steady-state mRNA levels. Drastic changes are observed, however, in the mRNAs coding for muscle actins, particularly the mRNAs coding for the jump and flight muscle actins. ..
  15. Methot N, Basler K. An absolute requirement for Cubitus interruptus in Hedgehog signaling. Development. 2001;128:733-42 pubmed
  16. Schwaiger M, Stadler M, Bell O, Kohler H, Oakeley E, Schübeler D. Chromatin state marks cell-type- and gender-specific replication of the Drosophila genome. Genes Dev. 2009;23:589-601 pubmed publisher
    ..Together, our study reveals novel organizational principles of DNA replication of the Drosophila genome and suggests that H4K16ac is more closely correlated with replication timing than is transcription. ..
  17. Montagne J, Groppe J, Guillemin K, Krasnow M, Gehring W, Affolter M. The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered. Development. 1996;122:2589-97 pubmed
    ..We propose that DSRF acts at a key step between regulatory genes that define the early positional values in the developing wing disc and the subsequent localized expression of intervein-specific structural genes. ..
  18. Agarkova I, Auerbach D, Ehler E, Perriard J. A novel marker for vertebrate embryonic heart, the EH-myomesin isoform. J Biol Chem. 2000;275:10256-64 pubmed
    ..It represents the major myomesin isoform at early embryonic stages of heart but is rapidly down-regulated around birth. Thus, the strict developmental regulation of the EH-myomesin makes it an ideally suited marker for embryonic heart. ..
  19. Maier M, Berger P, Nave K, Suter U. Identification of the regulatory region of the peripheral myelin protein 22 (PMP22) gene that directs temporal and spatial expression in development and regeneration of peripheral nerves. Mol Cell Neurosci. 2002;20:93-109 pubmed
  20. Stump G, Durrer A, Klein A, Lütolf S, Suter U, Taylor V. Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain. Mech Dev. 2002;114:153-9 pubmed
    ..The distribution of Notch1 and its putative ligands suggest distinct roles in specific subsets of cells in the postnatal brain including putative stem cells and differentiated neurons. ..
  21. Hafen E, Stocker H. How are the sizes of cells, organs, and bodies controlled?. PLoS Biol. 2003;1:E86 pubmed
  22. Braissant O, Henry H, Villard A, Speer O, Wallimann T, Bachmann C. Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1. BMC Dev Biol. 2005;5:9 pubmed
    ..This work provides new clues on how creatine can be provided to developing tissues, and suggests that Cr deficiencies might induce irreversible damages already in utero, particularly on the nervous system. ..
  23. Buchon N, Broderick N, Chakrabarti S, Lemaitre B. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev. 2009;23:2333-44 pubmed publisher
    ..Altogether, these results indicate that gut homeostasis is achieved by a complex interregulation of the immune response, gut microbiota, and stem cell activity...
  24. Johansson B, Wiles M. Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol Cell Biol. 1995;15:141-51 pubmed
    ..Together, our data strongly implicate the TGF-beta family in mammalian mesoderm development and hematopoietic cell formation. ..
  25. Wiedemann M, Trueb B, Belluoccio D. Molecular cloning of avian matrix Gla protein. Biochim Biophys Acta. 1998;1395:47-9 pubmed
    ..Our sequence data should be helpful in the design of mutational analyses which are intended to characterize functional interactions of matrix Gla proteins with other proteins. ..
  26. Pavlovic M, Schaller A, Pfammatter J, Carrel T, Berdat P, Gallati S. Age-dependent suppression of SERCA2a mRNA in pediatric atrial myocardium. Biochem Biophys Res Commun. 2005;326:344-8 pubmed
    ..Age itself did not influence the SERCA2a and PLB expression, if the hemodynamic overload was not taken into account. This study is the first to show a combined influence of volume overload and age on atrial SERCA2a expression. ..
  27. Chatterjee S, Grosshans H. Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature. 2009;461:546-9 pubmed publisher
    ..This pathway might represent a potential target for therapeutic intervention on miRNA expression. ..
  28. Schafer B, Czerny T, Bernasconi M, Genini M, Busslinger M. Molecular cloning and characterization of a human PAX-7 cDNA expressed in normal and neoplastic myocytes. Nucleic Acids Res. 1994;22:4574-82 pubmed
    ..However, transcripts for either PAX-3 and/or PAX-7 were expressed at elevated levels in tumorigenic rhabdomyosarcoma cell lines. Hence, overexpression of these PAX genes may be involved in the genesis of myogenic tumors. ..
  29. Johnston A, Matveeva E, Kirioukhova O, Grossniklaus U, Gruissem W. A dynamic reciprocal RBR-PRC2 regulatory circuit controls Arabidopsis gametophyte development. Curr Biol. 2008;18:1680-6 pubmed publisher
    ..Surprisingly, PRC2-specific H3K27-trimethylation activity represses paternal RBR allele, suggesting a functional role for a dynamic and reciprocal RBR-PRC2 regulatory circuit in cellular differentiation and reproductive development. ..
  30. Nadra K, Quignodon L, Sardella C, Joye E, Mucciolo A, Chrast R, et al. PPARgamma in placental angiogenesis. Endocrinology. 2010;151:4969-81 pubmed publisher
    ..Together our data demonstrate that PPAR? plays a pivotal role in controlling placental vascular proliferation and contributes to its termination in late pregnancy. ..
  31. Ruiz P, Schwärzler C, Gunthert U. CD44 isoforms during differentiation and development. Bioessays. 1995;17:17-24 pubmed
  32. Miljkovic Licina M, Gauchat D, Galliot B. Neuronal evolution: analysis of regulatory genes in a first-evolved nervous system, the hydra nervous system. Biosystems. 2004;76:75-87 pubmed
    ..These data strengthen the fact that two distinct regulations, one for neurogenesis and another for patterning, already apply to these regulatory genes, a feature also identified in bilaterian related genes...
  33. Chennakesava C, di Santo S, Ziemiecki A, Schneider H, Andres A. Differential expression of the receptor tyrosine kinase EphB4 and its ligand Ephrin-B2 during human placental development. Placenta. 2006;27:959-67 pubmed
    ..These experiments suggest that EphB4 and ephrin-B2 are instrumental in the establishment of a functional placental structure and of the utero-placental circulation. ..
  34. Ben Haim N, Lu C, Guzman Ayala M, Pescatore L, Mesnard D, Bischofberger M, et al. The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. Dev Cell. 2006;11:313-23 pubmed
    ..Based on mathematical modeling, we discuss how these sequential loops control cell fate. ..
  35. Pirrotta V, Chan C, McCabe D, Qian S. Distinct parasegmental and imaginal enhancers and the establishment of the expression pattern of the Ubx gene. Genetics. 1995;141:1439-50 pubmed
    ..The interaction of these elements results in the correct expression of Ubx in imaginal tissues. ..
  36. Studer F, Fedele D, Marowsky A, Schwerdel C, Wernli K, Vogt K, et al. Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme. Neuroscience. 2006;142:125-37 pubmed
  37. Ciarloni L, Mallepell S, Brisken C. Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A. 2007;104:5455-60 pubmed
    ..Thus, amphiregulin is an important paracrine mediator of estrogen function specifically required for puberty-induced ductal elongation, but not for any earlier or later developmental stages. ..
  38. Lütolf S, Radtke F, Aguet M, Suter U, Taylor V. Notch1 is required for neuronal and glial differentiation in the cerebellum. Development. 2002;129:373-85 pubmed
    ..We have also analyzed the effects of Notch1 ablation on gliogenesis in vivo. Our results show that Notch1 is required for both neuron and glia formation and modulates the onset of neurogenesis within the cerebellar neuroepithelium. ..
  39. Bello B, Izergina N, Caussinus E, Reichert H. Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development. Neural Dev. 2008;3:5 pubmed publisher
    ..This suggests that key aspects of neural stem cell biology might be conserved in brain development of insects and mammals. ..
  40. Pauls D, Selcho M, Gendre N, Stocker R, Thum A. Drosophila larvae establish appetitive olfactory memories via mushroom body neurons of embryonic origin. J Neurosci. 2010;30:10655-66 pubmed publisher
    ..Based on this approach, we define 10 subdomains of the larval mushroom body that may be implicated in mediating specific interactions between the olfactory pathway, modulatory neurons, and neuronal output. ..
  41. Pirrotta V. Chromatin complexes regulating gene expression in Drosophila. Curr Opin Genet Dev. 1995;5:466-72 pubmed
    ..How they persist through cell proliferation and how they silence gene activity are still open issues. ..
  42. Fabre Jonca N, Allaman J, Radlgruber G, Meda P, Kiss J, French L, et al. The distribution of murine 115-kDa epithelial microtubule-associated protein (E-MAP-115) during embryogenesis and in adult organs suggests a role in epithelial polarization and differentiation. Differentiation. 1998;63:169-80 pubmed
    ..Taken together, our results provide support for a role of E-MAP-115 in reorganizing the microtubule cytoskeleton during epithelial cell polarization and differentiation. ..
  43. Barges S, Mihaly J, Galloni M, Hagstrom K, Muller M, Shanower G, et al. The Fab-8 boundary defines the distal limit of the bithorax complex iab-7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain. Development. 2000;127:779-90 pubmed
    ..Fab-8 together with the previously identified Fab-7 boundary delimit the first genetically defined higher order domain in a multicellular eukaryote. ..
  44. Ebner A, Kiefer F, Ribeiro C, Petit V, Nussbaumer U, Affolter M. Tracheal development in Drosophila melanogaster as a model system for studying the development of a branched organ. Gene. 2002;287:55-66 pubmed
    ..We also identified a Sulfotransferase and a Multiple Inositol Polyphosphate phosphatase that are strongly upregulated in tracheal cells and discuss their possible involvement in tracheal development. ..
  45. Pyrowolakis G, Hartmann B, Muller B, Basler K, Affolter M. A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Dev Cell. 2004;7:229-40 pubmed
  46. Yamamoto Y, Girard F, Bello B, Affolter M, Gehring W. The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen. Development. 1997;124:3385-94 pubmed
    ..Together, our data suggest that these two proteins are involved in a common regulatory pathway and highlight possible interactions between Pc-G-mediated silencing and DNA replication in Drosophila. ..
  47. Skowronska Krawczyk D, Matter Sadzinski L, Ballivet M, Matter J. The basic domain of ATH5 mediates neuron-specific promoter activity during retina development. Mol Cell Biol. 2005;25:10029-39 pubmed
  48. Schonthaler H, Lampert J, Isken A, Rinner O, Mader A, Gesemann M, et al. Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur J Neurosci. 2007;26:1940-9 pubmed
    ..Thus, our study of zebrafish provides in vivo evidence for the existence of an RPE65-independent pathway for the regeneration of 11-cis-retinal for cone vision. ..
  49. Saner C, Weibel B, Wurgler F, Sengstag C. Metabolism of promutagens catalyzed by Drosophila melanogaster CYP6A2 enzyme in Saccharomyces cerevisiae. Environ Mol Mutagen. 1996;27:46-58 pubmed
    ..Two other compounds, 7,12-dimethylbenz[a]anthracene (DMBA) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), were metabolized in the transformed strain to cytotoxic products. ..
  50. Halder G, Callaerts P, Flister S, Walldorf U, Kloter U, Gehring W. Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development. 1998;125:2181-91 pubmed
    ..Recent studies in vertebrate systems indicate that the epistatic relationships among the corresponding vertebrate homologs are very similar to those observed in Drosophila. ..
  51. Berger P, Kozlov S, Krueger S, Sonderegger P. Structure of the mouse gene for the serine protease inhibitor neuroserpin (PI12). Gene. 1998;214:25-33 pubmed
    ..Sequence analysis revealed a TATA-less promoter with a CAAT box and several sites for the general transcription factor Sp1 and the neuron-specific transcription factor AP-2. ..
  52. Beckers J, Duboule D. Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach?. Dev Dyn. 1998;213:1-11 pubmed
    ..This unexpected observation may show the limitations of the former technology. Alternatively, it could illustrate a redundancy in regulatory circuits and, thus, justify the combination of parallel strategies. ..
  53. Pennetta G, Pauli D. The Drosophila Sin3 gene encodes a widely distributed transcription factor essential for embryonic viability. Dev Genes Evol. 1998;208:531-6 pubmed
    ..In addition, the domain of binding to the histone deacetylase Rpd3 is strongly conserved. Null mutations cause recessive embryonic lethality. ..
  54. Affolter M, Mann R. Development. Legs, eyes, or wings--selectors and signals make the difference. Science. 2001;292:1080-1 pubmed
  55. Grieder N, Kloter U, Gehring W. Expression of COPI components during development of Drosophila melanogaster. Gene Expr Patterns. 2005;6:11-21 pubmed
  56. Samardzija M, Wenzel A, Naash M, REme C, Grimm C. Rpe65 as a modifier gene for inherited retinal degeneration. Eur J Neurosci. 2006;23:1028-34 pubmed
    ..Increased absorption of photons and/or light sensitivity appear to accelerate retinal degeneration via an apoptotic cascade which involves phototransduction but not c-Fos. ..
  57. Mitsiadis T, Tucker A, De Bari C, Cobourne M, Rice D. A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination. Dev Biol. 2008;320:39-48 pubmed publisher
    ..Forced expression of Tbx1 in dental explants activates amelogenin expression. These results indicate that Tbx1 expression in developing teeth is under control of FGF signaling and correlates with determination of the ameloblast lineage. ..
  58. Krapp A, Knöfler M, Frutiger S, Hughes G, Hagenbuchle O, Wellauer P. The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein. EMBO J. 1996;15:4317-29 pubmed
    ..Thus the pancreas-specific DNA-binding activity of PTF1 originates from the synthesis of at least one cell-specific component rather than from a cell-specific assembly of more widely distributed proteins. ..
  59. Spaniol P, Bornmann C, Hauptmann G, Gerster T. Class III POU genes of zebrafish are predominantly expressed in the central nervous system. Nucleic Acids Res. 1996;24:4874-81 pubmed
    ..Analysis of the expression of the class III genes shows that they are predominantly expressed in the central nervous system and that they may play important roles in patterning the embryonic brain. ..
  60. Vincent S, Wilson R, Coelho C, Affolter M, Leptin M. The Drosophila protein Dof is specifically required for FGF signaling. Mol Cell. 1998;2:515-25 pubmed
    ..Dof is needed in these cells for activation of the MAPK cascade via FGF signaling, but not for activation via other RTK ligands. Dof therefore appears to be committed exclusively to FGFR-mediated signal transduction. ..
  61. Hoier E, Mohler W, Kim S, Hajnal A. The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression. Genes Dev. 2000;14:874-86 pubmed
    ..Thus, APR-1 may positively regulate the activity of the beta-Catenin/Armadillo-related proteins HMP-2 in migrating epithelial cells and BAR-1 in the vulval precursor cells...
  62. Groger H, Callaerts P, Gehring W, Schmid V. Characterization and expression analysis of an ancestor-type Pax gene in the hydrozoan jellyfish Podocoryne carnea. Mech Dev. 2000;94:157-69 pubmed
    ..The expression data indicate that Pax-B is involved in nerve cell differentiation...
  63. Leemans R, Loop T, Egger B, He H, Kammermeier L, Hartmann B, et al. Identification of candidate downstream genes for the homeodomain transcription factor Labial in Drosophila through oligonucleotide-array transcript imaging. Genome Biol. 2001;2:RESEARCH0015 pubmed
    ..Our results identify a number of novel candidate downstream target genes for Labial, suggesting that this homeoprotein differentially regulates a limited and distinct set of embryonically expressed Drosophila genes. ..
  64. Jentsch S, Tobler H, Muller F. New telomere formation during the process of chromatin diminution in Ascaris suum. Int J Dev Biol. 2002;46:143-8 pubmed
    ..This result suggests that de novo telomere formation during the process of chromatin diminution represents a non-specific process which can heal any broken DNA end...
  65. Merabet S, Ebner A, Affolter M. The Drosophila Extradenticle and Homothorax selector proteins control branchless/FGF expression in mesodermal bridge-cells. EMBO Rep. 2005;6:762-8 pubmed
    ..These findings provide a hitherto unknown and interesting link between combinatorial inputs of transcription factors, cell-specific ligand expression and organ morphogenesis. ..
  66. Montavon T, Le Garrec J, Kerszberg M, Duboule D. Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness. Genes Dev. 2008;22:346-59 pubmed publisher
    ..We also show that the same model applies to the collinear regulation of Hox genes during the emergence of external genitalia, though with some differences likely illustrating the distinct functionalities of these structures in adults. ..
  67. Lin S, Landmann L, Ruegg M, Brenner H. The role of nerve- versus muscle-derived factors in mammalian neuromuscular junction formation. J Neurosci. 2008;28:3333-40 pubmed publisher
    ..A model is proposed that explains either the neurocentric or the myocentric mode of NMJ formation depending on a balance between the levels of MuSK expression and the availability of nerve-released agrin. ..
  68. Shi Y, Noll M. Determination of cell fates in the R7 equivalence group of the Drosophila eye by the concerted regulation of D-Pax2 and TTK88. Dev Biol. 2009;331:68-77 pubmed publisher
    ..Thus, the fates of R1/R6/R7 and cone cells are determined by a dual mechanism that coordinately activates one fate while inhibiting the other. ..
  69. Afshar K, Werner M, Tse Y, Glotzer M, GONCZY P. Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos. Development. 2010;137:237-47 pubmed publisher
    ..Our findings provide the first insights into the role of a member of the PP6 family of phosphatases in metazoan development...
  70. Li F, Strange R, Friis R, Djonov V, Altermatt H, Saurer S, et al. Expression of stromelysin-1 and TIMP-1 in the involuting mammary gland and in early invasive tumors of the mouse. Int J Cancer. 1994;59:560-8 pubmed
    ..Thus, expression of stromelysin-1 and TIMP-1 is confined to the aggressively growing tumors and is induced in the earliest stages of carcinogenesis. ..
  71. Gerard M, Chen J, Gronemeyer H, Chambon P, Duboule D, Zakany J. In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries. Genes Dev. 1996;10:2326-34 pubmed
    ..These results illustrate the sharing, in cis, of a single regulatory element in order to establish the expression boundaries of two neighboring Hoxd genes. ..
  72. Vincent S, Ruberte E, Grieder N, Chen C, Haerry T, Schuh R, et al. DPP controls tracheal cell migration along the dorsoventral body axis of the Drosophila embryo. Development. 1997;124:2741-50 pubmed
    ..It is required to control the dorsal expression of the BNL ligand; in addition, the DPP signal recruits groups of dorsal and ventral tracheal cells and programs them to migrate in dorsal and ventral directions. ..
  73. Cléard F, Delattre M, Spierer P. SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation. EMBO J. 1997;16:5280-8 pubmed
    ..In addition, the two loci interact genetically, and the two proteins co-immunoprecipitate from nuclear extracts. The results suggest that SU(VAR)3-7 and HP1 co-operate in building the genomic silencing associated with heterochromatin. ..
  74. Krueger S, Ghisu G, Cinelli P, Gschwend T, Osterwalder T, Wolfer D, et al. Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. J Neurosci. 1997;17:8984-96 pubmed
    ..During development, neuroserpin may attenuate extracellular proteolysis related to processes such as neuronal migration, axogenesis, or the formation of mature synaptic connections. ..
  75. Kuhn F, Lassing C, Range A, Mueller M, Hunziker T, Ziemiecki A, et al. Pmg-1 and pmg-2 constitute a novel family of KAP genes differentially expressed during skin and mammary gland development. Mech Dev. 1999;86:193-6 pubmed
  76. Mazroui R, Puoti A, Kramer A. Splicing factor SF1 from Drosophila and Caenorhabditis: presence of an N-terminal RS domain and requirement for viability. RNA. 1999;5:1615-31 pubmed
    ..Injection of double-stranded RNA into C. elegans results in embryonic lethality; thus, the SF1 gene is essential not only in yeast but also in at least one metazoan. ..
  77. Horard B, Tatout C, Poux S, Pirrotta V. Structure of a polycomb response element and in vitro binding of polycomb group complexes containing GAGA factor. Mol Cell Biol. 2000;20:3187-97 pubmed
    ..Other fragments lack GAGA binding sites but can still bind PcG complexes in vitro. We show that the GAGA factor is a component of at least some types of PcG complexes and may participate in the assembly of PcG complexes at PREs. ..
  78. Poux S, Horard B, Sigrist C, Pirrotta V. The Drosophila trithorax protein is a coactivator required to prevent re-establishment of polycomb silencing. Development. 2002;129:2483-93 pubmed
    ..Targeting a histone acetylase to a PRE does not affect embryonic silencing but causes a loss of memory in imaginal discs, suggesting that deacetylation is required to establish the memory of the repressed state. ..
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