Experts and Doctors on deoxyribonucleotides in Sweden
Usova E, Maltseva T, Földesi A, Chattopadhayaya J, Eriksson S. Human deoxycytidine kinase as a deoxyribonucleoside phosphorylase. J Mol Biol. 2004;344:1347-58 pubmed
..This catalytic activity is important for the design of in vitro experiments with dCK, such as crystallization and NMR spectroscopy. ..
Håkansson P, Hofer A, Thelander L. Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells. J Biol Chem. 2006;281:7834-41 pubmed
Kumar D, Abdulovic A, Viberg J, Nilsson A, Kunkel T, Chabes A. Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools. Nucleic Acids Res. 2011;39:1360-71 pubmed publisher
..An interesting mutational strand bias is observed in one rnr1 strain, suggesting that the S-phase checkpoint selectively prevents replication errors during leading strand replication. ..
Håkansson P, Dahl L, Chilkova O, Domkin V, Thelander L. The Schizosaccharomyces pombe replication inhibitor Spd1 regulates ribonucleotide reductase activity and dNTPs by binding to the large Cdc22 subunit. J Biol Chem. 2006;281:1778-83 pubmed
..This increase is smaller than the increase observed in budding yeast but of the same order as the dNTP pool increase when synchronous Schizosaccharomyces pombe cdc10 cells are going from G1 to S-phase. ..
Sabouri N, Viberg J, Goyal D, Johansson E, Chabes A. Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage. Nucleic Acids Res. 2008;36:5660-7 pubmed publisher
..The nucleotide inserted opposite 8-oxoG is dATP. We propose that during DNA damage in S. cerevisiae increased dNTP concentration allows replicative DNA polymerases to bypass certain DNA lesions. ..
Kollberg G, Darin N, Benan K, Moslemi A, Lindal S, Tulinius M, et al
. A novel homozygous RRM2B missense mutation in association with severe mtDNA depletion. Neuromuscul Disord. 2009;19:147-50 pubmed publisher
..This is the third report on mutations in RRM2B associated with severe mtDNA depletion, which further highlights the importance of de novo synthesis of deoxyribonucleotides (dNTPs) for mtDNA maintenance. ..
Zahedi Avval F, Holmgren A. Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase. J Biol Chem. 2009;284:8233-40 pubmed publisher
..Our results demonstrate mechanistic differences between the mammalian and canonical Escherichia coli RNR enzymes, which may offer an explanation for the nonconserved shuttle dithiol sequences in the C terminus of the R1. ..
Kumar D, Viberg J, Nilsson A, Chabes A. Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint. Nucleic Acids Res. 2010;38:3975-83 pubmed publisher
..In contrast, when none of the dNTPs was limiting for DNA replication, even extreme and mutagenic dNTP pool imbalances did not activate the S-phase checkpoint and did not interfere with the cell cycle progression. ..
Rentoft M, Lindell K, Tran P, Chabes A, Buckland R, Watt D, et al
. Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance. Proc Natl Acad Sci U S A. 2016;113:4723-8 pubmed publisher
..These observations suggest that heterozygous cancer-associated SAMHD1 mutations increase mutation rates in cancer cells. ..