Experts and Doctors on cytosol in Germany


Locale: Germany
Topic: cytosol

Top Publications

  1. Krummrei U, Bang R, Schmidtchen R, Brune K, Bang H. Cyclophilin-A is a zinc-dependent DNA binding protein in macrophages. FEBS Lett. 1995;371:47-51 pubmed
    ..The zinc inhibited CypA does not bind cyclosporin A (CsA). We suggest that nuclear Cyp in complex with zinc ions recognizes DNA sequences and is involved in transcription modulating processes. ..
  2. Korthaus D, Wedemeyer N, Wiegand C, Jockusch H. The gene for cytoplasmatic malate dehydrogenase, Mor2, is closely linked to the wobbler spinal muscular atrophy gene (wr). Mamm Genome. 1996;7:250 pubmed
  3. Krepinsky K, Plaumann M, Martin W, Schnarrenberger C. Purification and cloning of chloroplast 6-phosphogluconate dehydrogenase from spinach. Cyanobacterial genes for chloroplast and cytosolic isoenzymes encoded in eukaryotic chromosomes. Eur J Biochem. 2001;268:2678-86 pubmed
    ..brucei (a relative of Euglena gracilis) may be secondarily nonphotosynthetic...
  4. Hartmann Stühler C, Prange R. Hepatitis B virus large envelope protein interacts with gamma2-adaptin, a clathrin adaptor-related protein. J Virol. 2001;75:5343-51 pubmed
    ..Together, the results suggest a role for gamma2-adaptin in L-mediated processes of viral biogenesis and/or pathogenesis, such as facilitating and guiding HBV assembly. ..
  5. Ruhl R, Plum C, Elmazar M, Nau H. Embryonic subcellular distribution of 13-cis- and all-trans-retinoic acid indicates differential cytosolic/nuclear localization. Toxicol Sci. 2001;63:82-9 pubmed
    ..The teratogenic activity of 13-cis-retinoic acid could therefore be explained by its access to the nucleus and its possible conversion to all-trans-retinoic acids, which will interact with the nuclear retinoid receptors. ..
  6. Farré E, Tiessen A, Roessner U, Geigenberger P, Trethewey R, Willmitzer L. Analysis of the compartmentation of glycolytic intermediates, nucleotides, sugars, organic acids, amino acids, and sugar alcohols in potato tubers using a nonaqueous fractionation method. Plant Physiol. 2001;127:685-700 pubmed
    ..However, due to the low plastidic pyrophosphate concentration, the reaction catalyzed by ADP-glucose pyrophosphorylase was estimated to be far removed from equilibrium...
  7. Segond Von Banchet G, Pastor A, Biskup C, Schlegel C, Benndorf K, Schaible H. Localization of functional calcitonin gene-related peptide binding sites in a subpopulation of cultured dorsal root ganglion neurons. Neuroscience. 2002;110:131-45 pubmed
    ..The binding sites may serve as autoreceptors because all of these neurons also synthesize CGRP. The activation of CGRP binding sites may sensitize primary afferent neurons and influence the release of mediators. ..
  8. Failer B, Braun N, Zimmermann H. Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase. J Biol Chem. 2002;277:36978-86 pubmed
    ..Ca(2+)-dependent nucleoside diphosphatase may support glycosylation reactions related to quality control in the endoplasmic reticulum. ..
  9. Sodeik B. Unchain my heart, baby let me go--the entry and intracellular transport of HIV. J Cell Biol. 2002;159:393-5 pubmed
    ..The tracked particles correspond to functional units, since they no longer include a viral envelope, but do include viral matrix protein, Vpr, capsid protein, and reverse transcription activity. ..

More Information

Publications269 found, 100 shown here

  1. Klunker D, Haas B, Hirtreiter A, Figueiredo L, Naylor D, Pfeifer G, et al. Coexistence of group I and group II chaperonins in the archaeon Methanosarcina mazei. J Biol Chem. 2003;278:33256-67 pubmed
  2. Hartmann T, Hönicke P, Wirtz M, Hell R, Rennenberg H, Kopriva S. Regulation of sulphate assimilation by glutathione in poplars (Populus tremula x P. alba) of wild type and overexpressing gamma-glutamylcysteine synthetase in the cytosol. J Exp Bot. 2004;55:837-45 pubmed
    ..However, OAS measurements revealed that OAS cannot be the only signal responsible for the lack of feedback regulation of APR by GSH in the transgenic poplars. ..
  3. Jank T, Giesemann T, Aktories K. Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function. Glycobiology. 2007;17:15R-22R pubmed
    ..These studies, which provide new insights into structure, uptake, and function of the family of clostridial glucosylating toxins, are reviewed. ..
  4. Choi Y, Cowan D, Wahlers T, Hetzer R, del Nido P, Stamm C. Calcium sensitisation impairs diastolic relaxation in post-ischaemic myocardium: implications for the use of Ca(2+) sensitising inotropes after cardiac surgery. Eur J Cardiothorac Surg. 2010;37:376-83 pubmed publisher
    ..However, Ca(2+) sensitisers should be used with caution during post-ischaemic reperfusion, as they may exacerbate myocardial stunning and thus impair cardiac output. ..
  5. Lill R. Function and biogenesis of iron-sulphur proteins. Nature. 2009;460:831-8 pubmed publisher
    ..The importance of Fe-S proteins for life is documented by an increasing number of diseases linked to these components and their biogenesis. ..
  6. Dmochewitz L, Lillich M, Kaiser E, Jennings L, Lang A, Buchner J, et al. Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen. Cell Microbiol. 2011;13:359-73 pubmed publisher
    ..In conclusion, cyclophilin A and Hsp90 facilitate translocation of LF(N)DTA, but not of LF, across endosomal membranes, and thus they function selectively in promoting translocation of certain proteins, but not of others. ..
  7. Dumke R, Hausner M, Jacobs E. Role of Mycoplasma pneumoniae glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in mediating interactions with the human extracellular matrix. Microbiology. 2011;157:2328-38 pubmed publisher
    ..Thus, the surface-exposed fraction of GAPDH may be a factor that contributes to the successful colonization of the human respiratory tract by M. pneumoniae...
  8. Whiteley L, Meffert T, Haug M, Weidenmaier C, Hopf V, Bitschar K, et al. Entry, Intracellular Survival, and Multinucleated-Giant-Cell-Forming Activity of Burkholderia pseudomallei in Human Primary Phagocytic and Nonphagocytic Cells. Infect Immun. 2017;85: pubmed publisher
    ..In summary, the ability of the bacteria to enter and survive as well as induce MNGC formation in certain host cells may contribute to the pathogenesis observed in B. pseudomallei infection. ..
  9. Adamíková L, Straube A, Schulz I, Steinberg G. Calcium signaling is involved in dynein-dependent microtubule organization. Mol Biol Cell. 2004;15:1969-80 pubmed
    ..This indicates a connection between calcium signaling, dynein, and microtubule organization in morphogenesis of U. maydis. ..
  10. Lay D, L Grosshans B, Heid H, Gorgas K, Just W. Binding and functions of ADP-ribosylation factor on mammalian and yeast peroxisomes. J Biol Chem. 2005;280:34489-99 pubmed
    ..ScARF1 regulated this process in a positive manner, and ScARF3 regulated it in a negative manner. ..
  11. von Braun S, Sabetti A, Hanic Joyce P, Gu J, Schleiff E, Joyce P. Dual targeting of the tRNA nucleotidyltransferase in plants: not just the signal. J Exp Bot. 2007;58:4083-93 pubmed publisher
    ..These data indicate that regulation of dual localization involves not only specific N-terminal signals, but also additional factors within the protein or the cell. ..
  12. Nordhues A, Miller S, Mühlhaus T, Schroda M. New insights into the roles of molecular chaperones in Chlamydomonas and Volvox. Int Rev Cell Mol Biol. 2010;285:75-113 pubmed publisher
    ..The aim of this chapter is to describe recent advances toward understanding molecular chaperone biology in Chlamydomonas and Volvox...
  13. Wörner M, Melchior K, Monostory K, Pascussi J, Huber C, Bernhardt R. The effects of rosuvastatin and the CYP51A1 inhibitor LEK-935 on the proteome of primary human hepatocytes. Drug Metab Dispos. 2012;40:414-8 pubmed publisher
    ..Thus, new information and a deeper insight into the processes taking place inside cells treated with cholesterol-lowering agents can be drawn from this study. ..
  14. Seebacher T, Beitz E, Kumagami H, Wild K, Ruppersberg J, Schultz J. Expression of membrane-bound and cytosolic guanylyl cyclases in the rat inner ear. Hear Res. 1999;127:95-102 pubmed
  15. Breyer Pfaff U, Martin H, Ernst M, Maser E. Enantioselectivity of carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by tissue fractions from human and rat and by enzymes isolated from human liver. Drug Metab Dispos. 2004;32:915-22 pubmed
    ..Rat liver and lung microsomes produced NNAL with about 33% and 55% (R)-enantiomer and a mean contribution of 11beta-HSD1 of 12% and 32%, respectively. Multiple enzymes seem to participate in NNK reduction in human and rat tissues. ..
  16. Holtgrefe S, Gohlke J, Starmann J, Druce S, Klocke S, Altmann B, et al. Regulation of plant cytosolic glyceraldehyde 3-phosphate dehydrogenase isoforms by thiol modifications. Physiol Plant. 2008;133:211-28 pubmed publisher
  17. Bödding M, Wissenbach U, Flockerzi V. The recombinant human TRPV6 channel functions as Ca2+ sensor in human embryonic kidney and rat basophilic leukemia cells. J Biol Chem. 2002;277:36656-64 pubmed
    ..In conclusion, TRPV6, expressed in human embryonic kidney cells and in rat basophilic leukemia cells, functions as a Ca(2+)-sensing Ca(2+) channel independently of procedures known to deplete Ca(2+) stores. ..
  18. Bergmann F, Keller B. Impact of mitochondrial inhibition on excitability and cytosolic Ca2+ levels in brainstem motoneurones from mouse. J Physiol. 2004;555:45-59 pubmed
  19. Hampel D, Mosandl A, Wüst M. Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.): metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathways. Phytochemistry. 2005;66:305-11 pubmed
    ..Nevertheless, in xylem a de novo-biosynthesis of terpenes was detectable as well, even in the absence of oil ducts in this tissue. ..
  20. Schuberth C, Buchberger A. Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation. Nat Cell Biol. 2005;7:999-1006 pubmed
    ..Lack of Ubx2 causes defects in ERAD that are exacerbated under stress conditions. These findings are consistent with a model in which Ubx2 coordinates the assembly of a highly efficient ERAD machinery at the ER membrane. ..
  21. Fettke J, Chia T, Eckermann N, Smith A, Steup M. A transglucosidase necessary for starch degradation and maltose metabolism in leaves at night acts on cytosolic heteroglycans (SHG). Plant J. 2006;46:668-84 pubmed
    ..2.1.99). Additional starch-related mutants were characterized for further analysis of the increased glucosyl content. Based on these data, the cytosolic metabolism of starch-derived carbohydrates is discussed. ..
  22. Girzalsky W, Hoffmann L, Schemenewitz A, Nolte A, Kunau W, Erdmann R. Pex19p-dependent targeting of Pex17p, a peripheral component of the peroxisomal protein import machinery. J Biol Chem. 2006;281:19417-25 pubmed
  23. Voss M, Vitavska O, Walz B, Wieczorek H, Baumann O. Stimulus-induced phosphorylation of vacuolar H(+)-ATPase by protein kinase A. J Biol Chem. 2007;282:33735-42 pubmed
    ..These data suggest that subunit C binds to and serves as a substrate for protein kinase A and that this phosphorylation may be a regulatory switch for the formation of the active V(1)V(0) holoenzyme. ..
  24. Hirrlinger J, Dringen R. The cytosolic redox state of astrocytes: Maintenance, regulation and functional implications for metabolite trafficking. Brain Res Rev. 2010;63:177-88 pubmed publisher
  25. Dufer M, Noack K, Edalat A, Krippeit Drews P, Drews G. Glitazones exert multiple effects on β-cell stimulus-secretion coupling. Mol Pharmacol. 2013;83:51-60 pubmed publisher
    ..Troglitazone and pioglitazone differ in their influence on SSC. It can be assumed that the effects of pioglitazone on β-cells are negligible under in vivo conditions. ..
  26. Bosche B, Schafer M, Graf R, Härtel F, Schafer U, Noll T. Lithium prevents early cytosolic calcium increase and secondary injurious calcium overload in glycolytically inhibited endothelial cells. Biochem Biophys Res Commun. 2013;434:268-72 pubmed publisher
    ..Though further research is needed, these findings provide a novel option for therapeutic strategies to protect the endothelium against imminent barrier failure...
  27. Flinner N, Ellenrieder L, Stiller S, Becker T, Schleiff E, Mirus O. Mdm10 is an ancient eukaryotic porin co-occurring with the ERMES complex. Biochim Biophys Acta. 2013;1833:3314-3325 pubmed publisher
    ..Strikingly, the presence of Mdm10 coincides with the appearance of the other ERMES components. Mdm10's presence in both unikonts and bikonts indicates an introduction at an early time point in eukaryotic evolution. ..
  28. Marschall R, Schumacher J, Siegmund U, Tudzynski P. Chasing stress signals - Exposure to extracellular stimuli differentially affects the redox state of cell compartments in the wild type and signaling mutants of Botrytis cinerea. Fungal Genet Biol. 2016;90:12-22 pubmed publisher
    ..Finally, we report that CaCl2 as well as cell wall stress-inducing agents stimulate ROS production and that ?bcnoxB produces significantly less ROS than the wild type and ?bcnoxA. ..
  29. Schröder K, Weissmann N, Brandes R. Organizers and activators: Cytosolic Nox proteins impacting on vascular function. Free Radic Biol Med. 2017;109:22-32 pubmed publisher
    ..Finally, it will be discussed whether cytosolic Nox proteins are suitable pharmacological targets to tamper with vascular ROS production. ..
  30. Hentze H, Schmitz I, Latta M, Krueger A, Krammer P, Wendel A. Glutathione dependence of caspase-8 activation at the death-inducing signaling complex. J Biol Chem. 2002;277:5588-95 pubmed
    ..Our data indicate that the activation of caspase-8 at the DISC and hence CD95-mediated apoptosis induction shows a cell-specific requirement for intracellular glutathione. ..
  31. Hu B, Petrasch Parwez E, Laue M, Kilimann M. Molecular characterization and immunohistochemical localization of palmdelphin, a cytosolic isoform of the paralemmin protein family implicated in membrane dynamics. Eur J Cell Biol. 2005;84:853-66 pubmed
    ..These observations suggest that palmdelphin may peripherally associate with endomembranes or cytoskeleton-linked structures. ..
  32. Grotemeier A, Alers S, Pfisterer S, Paasch F, Daubrawa M, Dieterle A, et al. AMPK-independent induction of autophagy by cytosolic Ca2+ increase. Cell Signal. 2010;22:914-25 pubmed publisher
    ..We suggest that apart from reported AMPK-dependent regulation of autophagic degradation, an AMPK-independent pathway triggers Ca(2+)-mediated autophagy, involving the PI(3)P-effector protein WIPI-1 and LC3...
  33. Andréasson C, Rampelt H, Fiaux J, Druffel Augustin S, Bukau B. The endoplasmic reticulum Grp170 acts as a nucleotide exchange factor of Hsp70 via a mechanism similar to that of the cytosolic Hsp110. J Biol Chem. 2010;285:12445-53 pubmed publisher
    ..Thus, our findings demonstrate that despite some differences between Hsp110 and Grp170 proteins, they use a similar mechanism to trigger nucleotide exchange. ..
  34. Pal S, Liput M, Piques M, Ishihara H, Obata T, Martins M, et al. Diurnal changes of polysome loading track sucrose content in the rosette of wild-type arabidopsis and the starchless pgm mutant. Plant Physiol. 2013;162:1246-65 pubmed publisher
    ..Costs are also reduced by using amino acids that accumulated in the previous light period. These results uncover a tight coordination of protein synthesis with the momentary supply of carbon. ..
  35. Bamberger A, Bamberger C, Wald M, Kratzmeier M, Schulte H. Protein kinase C (PKC) isoenzyme expression pattern as an indicator of proliferative activity in uterine tumor cells. Mol Cell Endocrinol. 1996;123:81-8 pubmed
    ..Overexpression of PKC isoforms indicates a higher proliferative capacity, and may, thus, represent an important step in the pathogenesis of certain uterine malignancies...
  36. Uhrigshardt H, Walden M, John H, Anemuller S. Purification and characterization of the first archaeal aconitase from the thermoacidophilic Sulfolobus acidocaldarius. Eur J Biochem. 2001;268:1760-71 pubmed
    ..acidocaldarius sequence was found to be highly homologous to either other putative archaeal or known eukaryal and bacterial sequences. As shown by EPR-spectroscopy, the enzyme hosts an interconvertible [3Fe--4S] cluster...
  37. Igwe E, Geginat G, Rüssmann H. Concomitant cytosolic delivery of two immunodominant listerial antigens by Salmonella enterica serovar typhimurium confers superior protection against murine listeriosis. Infect Immun. 2002;70:7114-9 pubmed
    ..In conclusion, these findings emphasize the versatility of Salmonella type III-mediated heterologous antigen delivery for the induction of cytotoxic T-lymphocyte-mediated immunity. ..
  38. Welss T, Sun J, Irving J, Blum R, Smith A, Whisstock J, et al. Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis. Biochemistry. 2003;42:7381-9 pubmed
    ..Given that lysosomal disruption, release of catL, and catL-mediated caspase activation are known to occur in response to cellular stress, we propose that a physiological role of hurpin is to protect epithelial cells from ectopic catL. ..
  39. Magg T, Schreiner D, Solis G, Bade E, Hofer H. Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus. Exp Cell Res. 2005;307:100-8 pubmed
    ..In another step, the cleavage product was released to the cytosol and was also found in a low speed pellet fraction, in accordance with the nuclear localization of the cytoplasmic domain of hFat1. ..
  40. Becker D, Blase C, Bereiter Hahn J, Jendrach M. TRPV4 exhibits a functional role in cell-volume regulation. J Cell Sci. 2005;118:2435-40 pubmed
    ..RVD of TRPV4-transfected CHO cells was significantly reduced by Gd3+ treatment or in Ca2+-free solution. Taken together, these results show a direct participation of TRPV4 in RVD. ..
  41. Fettke J, Eckermann N, Tiessen A, Geigenberger P, Steup M. Identification, subcellular localization and biochemical characterization of water-soluble heteroglycans (SHG) in leaves of Arabidopsis thaliana L.: distinct SHG reside in the cytosol and in the apoplast. Plant J. 2005;43:568-85 pubmed
    ..As revealed by in vivo labeling experiments using 14CO2 carbon fluxes into subfraction I and II differed. Furthermore, in leaves the pool size of subfraction I varied during the light-dark regime. ..
  42. Pohlmann L, Kröger I, Vignier N, Schlossarek S, Kramer E, Coirault C, et al. Cardiac myosin-binding protein C is required for complete relaxation in intact myocytes. Circ Res. 2007;101:928-38 pubmed
    ..Our findings indicate that cMyBP-C functions as a restraint on myosin-actin interaction at low Ca2+ and short SL to allow complete relaxation during diastole. ..
  43. Phillips M, D Auria J, Gershenzon J, Pichersky E. The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis. Plant Cell. 2008;20:677-96 pubmed publisher
    ..Thus, each of the two Arabidopsis IPP isomerases is found in multiple but partially overlapping subcellular locations, and each can compensate for the loss of the other through partial redundancy in the cytosol. ..
  44. Timm S, Nunes Nesi A, Pärnik T, Morgenthal K, Wienkoop S, Keerberg O, et al. A cytosolic pathway for the conversion of hydroxypyruvate to glycerate during photorespiration in Arabidopsis. Plant Cell. 2008;20:2848-59 pubmed publisher
  45. Kentner D, Sourjik V. Use of fluorescence microscopy to study intracellular signaling in bacteria. Annu Rev Microbiol. 2010;64:373-90 pubmed publisher
    ..Moreover, microscopy enables investigation of single-cell gene expression kinetics, bringing such concepts as cell individuality and robustness against stochasticity of gene expression to the forefront of signaling studies. ..
  46. Drews A, Bovens S, Roebrock K, Sunderkotter C, Reinhardt D, Schäfers M, et al. 1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity. J Med Chem. 2010;53:5165-78 pubmed publisher
    ..A very high plasma clearance was observed after intravenous administration of 36 (10 mg/kg). However, in a topical murine model of contact dermatitis, 36 showed a pronounced anti-inflammatory in vivo activity. ..
  47. Wipfler D, Srinivasan G, Sadick H, Kniep B, Arming S, Willhauck Fleckenstein M, et al. Differentially regulated expression of 9-O-acetyl GD3 (CD60b) and 7-O-acetyl-GD3 (CD60c) during differentiation and maturation of human T and B lymphocytes. Glycobiology. 2011;21:1161-72 pubmed publisher
    ..Our data point to regulatory functions of these anabolic and catabolic key enzymes for the expression of GD3 and its O-acetylated variants in lymphocytes at a given differentiation stage. ..
  48. Schneider H, Alt M, Klier M, Spiess A, Andes F, Waheed A, et al. GPI-anchored carbonic anhydrase IV displays both intra- and extracellular activity in cRNA-injected oocytes and in mouse neurons. Proc Natl Acad Sci U S A. 2013;110:1494-9 pubmed publisher
    ..Our results suggest that membrane-associated CA IV contributes robust catalytic activity intracellularly, and that this activity participates in regulating H(+) dynamics in the cytosol, both in injected oocytes and in mouse neurons. ..
  49. Rabe A, Fromter E. Micromolar concentrations of steroids and of aldosterone antagonists inhibit the outwardly rectifying chloride channel with different kinetics. Pflugers Arch. 2000;439:559-66 pubmed
    ..This shows that there are even further modes of channel inhibition and argues against the cytosolic Cl- channel inhibitor being a steroid. ..
  50. Russmann H, Igwe E, Sauer J, Hardt W, Bubert A, Geginat G. Protection against murine listeriosis by oral vaccination with recombinant Salmonella expressing hybrid Yersinia type III proteins. J Immunol. 2001;167:357-65 pubmed
    ..This CD8 T cell response protected mice against a challenge with L. monocytogenes. In conclusion, these findings suggest that YopE is a versatile carrier molecule for type III-mediated foreign Ag delivery by Salmonella vaccine strains. ..
  51. Weber A, Flügge U. Interaction of cytosolic and plastidic nitrogen metabolism in plants. J Exp Bot. 2002;53:865-74 pubmed
    ..Glucose 6-phosphate, the immediate precursor of the oxidative pentose phosphate pathway is generated in the cytosol and imported into the plastids by the plastidic glucose 6-phosphate/phosphate translocator. ..
  52. Reppel M, Sasse P, Piekorz R, Tang M, Roell W, Duan Y, et al. S100A1 enhances the L-type Ca2+ current in embryonic mouse and neonatal rat ventricular cardiomyocytes. J Biol Chem. 2005;280:36019-28 pubmed
    ..We conclude that the Ca2+-binding protein S100A1 augments transsarcolemmal Ca2+ influx via an increase of PKA activity in ventricular cardiomyocytes and hence represents an important regulator of cardiac function. ..
  53. Speidel D, Helmbold H, Deppert W. Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress. Oncogene. 2006;25:940-53 pubmed
    ..Our results demonstrate the impact and in vivo relevance of non-transcriptional mechanisms for wild-type and mutant p53-mediated apoptosis. ..
  54. Rambold A, Miesbauer M, Rapaport D, Bartke T, Baier M, Winklhofer K, et al. Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP. Mol Biol Cell. 2006;17:3356-68 pubmed
    ..Our study reveals a compartment-specific toxicity of PrP misfolding that involves coaggregation of Bcl-2 and indicates a protective role of molecular chaperones. ..
  55. Stehling O, Netz D, Niggemeyer B, Rösser R, Eisenstein R, Puccio H, et al. Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis. Mol Cell Biol. 2008;28:5517-28 pubmed publisher
  56. Jores T, Rapaport D. Early stages in the biogenesis of eukaryotic ?-barrel proteins. FEBS Lett. 2017;591:2671-2681 pubmed publisher
    ..In this Review, we summarize the current knowledge about the biogenesis of ?-barrel proteins, focusing on the early stages from the translation on cytosolic ribosomes to the recognition on the surface of the organelle. ..
  57. Dietrich A, Dieminger W, Fuchte K, Stoll G, Schlitz E, Gerok W, et al. Functional significance of interaction of H-FABP with sulfated and nonsulfated taurine-conjugated bile salts in rat liver. J Lipid Res. 1995;36:1745-55 pubmed
    ..In intracellular transport of taurine-conjugated bile salts, several cytosolic polypeptides may have a function, whereas, in transport of taurine-conjugated 3 alpha-sulfato bile salts, only H-FABP appears to be involved. ..
  58. Tomoyasu T, Mogk A, Langen H, Goloubinoff P, Bukau B. Genetic dissection of the roles of chaperones and proteases in protein folding and degradation in the Escherichia coli cytosol. Mol Microbiol. 2001;40:397-413 pubmed
    ..At 42 degrees C, ClpXP and Lon became essential for viability of cells with low DnaK levels, indicating synergistic action of proteases and the DnaK system, which is essential for cell growth at 42 degrees C. ..
  59. Kalthoff C, Alves J, Urbanke C, Knorr R, Ungewickell E. Unusual structural organization of the endocytic proteins AP180 and epsin 1. J Biol Chem. 2002;277:8209-16 pubmed
  60. Huth W, Rolle S, Wunderlich I. Turnover of matrix proteins in mammalian mitochondria. Biochem J. 2002;364:275-84 pubmed
  61. Rüssmann H. Inverted pathogenicity: the use of pathogen-specific molecular mechanisms for prevention or therapy of disease. Int J Med Microbiol. 2004;293:565-9 pubmed
    ..Surprisingly, cytosolic delivery of YopE/LLO by Yersinia also results in LLO-specific CD4 T-cell priming. ..
  62. Quensel C, Friedrich B, Sommer T, Hartmann E, Kohler M. In vivo analysis of importin alpha proteins reveals cellular proliferation inhibition and substrate specificity. Mol Cell Biol. 2004;24:10246-55 pubmed
    ..Thus, importin alpha3 is the only alpha importin responsible for the classical nuclear import of RCC1 in living cells. ..
  63. Werner C, Godfrey V, Arnold R, Featherstone G, Bender D, Schlossmann J, et al. Neutrophil dysfunction in guanosine 3',5'-cyclic monophosphate-dependent protein kinase I-deficient mice. J Immunol. 2005;175:1919-29 pubmed
    ..In summary, these results show that cGKIalpha down-regulates Ca2+ transients and chemotaxis in murine neutrophils. The regulatory influences of cGKIalpha on the secretagogue responses are complex, depending on the granule subtype. ..
  64. Rajalingam K, Wunder C, Brinkmann V, Churin Y, Hekman M, Sievers C, et al. Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. Nat Cell Biol. 2005;7:837-43 pubmed
    ..Our data show an unexpected role of prohibitin in the activation of the Ras-Raf signalling pathway and in modulating epithelial cell adhesion and migration. ..
  65. Krieger A, Radhakrishnan K, Pereverzev A, Siapich S, Banat M, Kamp M, et al. The molecular chaperone hsp70 interacts with the cytosolic II-III loop of the Cav2.3 E-type voltage-gated Ca2+ channel. Cell Physiol Biochem. 2006;17:97-110 pubmed
    ..3 splice variants stimulate autophosphorylation of PKCa, leading to the suggestion that hsp70--binding to the II-III loop--may act as an adaptor for Ca2+ dependent targeting of PKC to E-type Ca2+ channels. ..
  66. Braun R, Zischka H, Madeo F, Eisenberg T, Wissing S, Buttner S, et al. Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast. J Biol Chem. 2006;281:25757-67 pubmed
    ..Concomitantly, emergence of caspase-like enzymatic activity occurs suggesting a role for caspases in the cell death process. These data strongly point for the first time to a mitochondrial involvement in Cdc48p/VCP-dependent apoptosis. ..
  67. Biederbick A, Stehling O, Rösser R, Niggemeyer B, Nakai Y, Elsässer H, et al. Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation. Mol Cell Biol. 2006;26:5675-87 pubmed
    ..The results have implications for the regulation of iron homeostasis by cytosolic iron regulatory protein 1. ..
  68. Grauvogel C, Petersen J. Isoprenoid biosynthesis authenticates the classification of the green alga Mesostigma viride as an ancient streptophyte. Gene. 2007;396:125-33 pubmed
    ..Our data indicate that the MVA pathway is a characteristic trait of Plantae in general and propose that it was specifically lost in a common ancestor of Chlorophyta...
  69. Scharte J, Schön H, Tjaden Z, Weis E, von Schaewen A. Isoenzyme replacement of glucose-6-phosphate dehydrogenase in the cytosol improves stress tolerance in plants. Proc Natl Acad Sci U S A. 2009;106:8061-6 pubmed publisher
    ..Because isoenzyme replacement of G6PDH in the cytosol was beneficial under various kinds of cues, we propose this strategy as a tool to enhance stress tolerance in general. ..
  70. Roelfsema M, Hedrich R. Making sense out of Ca(2+) signals: their role in regulating stomatal movements. Plant Cell Environ. 2010;33:305-21 pubmed publisher
    ..Future research may shed new light on the relation between parallel acting Ca(2+)-dependent and -independent events, and may provide insights in their evolutionary origin. ..
  71. Blum R, Meyer K, Wünschmann J, Lendzian K, Grill E. Cytosolic action of phytochelatin synthase. Plant Physiol. 2010;153:159-69 pubmed publisher
    ..Hence, PCS contributes specifically to the cytosolic turnover of GS conjugates, and AtPCS1 plays the prominent role. We discuss a potential function of PCS in the cytosolic turnover of GS conjugates. ..
  72. Wild R, Gerasimaite R, Jung J, Truffault V, Pavlovic I, Schmidt A, et al. Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains. Science. 2016;352:986-90 pubmed publisher
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