Experts and Doctors on cytokines in Switzerland

Summary

Locale: Switzerland
Topic: cytokines

Top Publications

  1. Colonna M, Nakajima H, Cella M. Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells. J Leukoc Biol. 1999;66:718-22 pubmed
    ..Whereas some receptors inhibit, others induce cell activation. 2B4 is broadly expressed on leukocytes, binds CD48, and mediates non-MHC-restricted cytotoxicity by NK cells. ..
  2. Obexer Ruff G, Sattler U, Martinez D, Maillard J, Chartier C, Saitbekova N, et al. Association studies using random and "candidate" microsatellite loci in two infectious goat diseases. Genet Sel Evol. 2003;35 Suppl 1:S113-9 pubmed
    ..The MHC class II locus DYA (P19), was weakly associated with susceptibility in both diseases (Pc = 0.05). In future experiments, we will extend the sample size in order to verify the described associations. ..
  3. Schwager K, Kaspar M, Bootz F, Marcolongo R, Paresce E, Neri D, et al. Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis. Arthritis Res Ther. 2009;11:R142 pubmed publisher
  4. Kucuksezer U, Palomares O, Rückert B, Jartti T, Puhakka T, Nandy A, et al. Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood. J Allergy Clin Immunol. 2013;131:875-85 pubmed publisher
  5. Akdis M, Palomares O, Van De Veen W, van Splunter M, Akdis C. TH17 and TH22 cells: a confusion of antimicrobial response with tissue inflammation versus protection. J Allergy Clin Immunol. 2012;129:1438-49; quiz1450-1 pubmed publisher
  6. Car B, Meloni F, Luisetti M, Semenzato G, Gialdroni Grassi G, Walz A. Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Respir Crit Care Med. 1994;149:655-9 pubmed
    ..It appears likely that both of these chemoattractants contribute to the influx of monocytes and neutrophils into the pulmonary alveolus and interstitium in these diseases. ..
  7. Oxenius A, Karrer U, Zinkernagel R, Hengartner H. IL-12 is not required for induction of type 1 cytokine responses in viral infections. J Immunol. 1999;162:965-73 pubmed
  8. Trautmann A, Rückert B, Schmid Grendelmeier P, Niederer E, Brocker E, Blaser K, et al. Human CD8 T cells of the peripheral blood contain a low CD8 expressing cytotoxic/effector subpopulation. Immunology. 2003;108:305-12 pubmed
    ..Therefore, the CD8low population represent a subset of activated CD8 effector T cells, resulting most probably from a continuous and/or balanced immune response to intracellular pathogens. ..
  9. Schwager K, Bootz F, Imesch P, Kaspar M, Trachsel E, Neri D. The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model. Hum Reprod. 2011;26:2344-52 pubmed publisher
    ..The F8 antibody targets endometriotic lesions in vivo in a mouse model of endometriosis and may be used for the non-invasive imaging of the disease and for the pharmacodelivery of anti-inflammatory cytokines, such as IL10. ..

More Information

Publications154 found, 100 shown here

  1. Maloy K, Burkhart C, Junt T, Odermatt B, Oxenius A, Piali L, et al. CD4(+) T cell subsets during virus infection. Protective capacity depends on effector cytokine secretion and on migratory capability. J Exp Med. 2000;191:2159-70 pubmed
    ..Therefore, the antiviral protective capacity of a given CD4(+) T cell is governed by the effector cytokines it produces and by its migratory capability. ..
  2. Bas S, Neff L, Vuillet M, Spenato U, Seya T, Matsumoto M, et al. The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14. J Immunol. 2008;180:1158-68 pubmed
    ..Stimulating pathways appeared to involve TLR2/TLR1/TLR6 with the help of CD14 but not TLR4. These data support a role of Mip lipoprotein in pathogenesis of C. trachomatis-induced inflammatory responses. ..
  3. Schwager J, Hoeller U, Wolfram S, Richard N. Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression. BMC Complement Altern Med. 2011;11:105 pubmed publisher
    ..These data provide a molecular and biochemical basis for cartilage protection provided by RHP. ..
  4. Olleros M, Martin M, Vesin D, Fotio A, Santiago Raber M, Rubbia Brandt L, et al. Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines. Cytokine. 2008;44:118-25 pubmed publisher
    ..In this model, changes in the regulation of TNF are associated with increased expression of IL-6, IFN-gamma, and iNOS. ..
  5. Di Mitri D, Alimonti A. Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer. Trends Cell Biol. 2016;26:215-26 pubmed publisher
    ..Such evidence demonstrates that senescence initiation also relies on non-cell-autonomous mechanisms, which are discussed in the present review. ..
  6. Schaerli P, Ebert L, Willimann K, Blaser A, Roos R, Loetscher P, et al. A skin-selective homing mechanism for human immune surveillance T cells. J Exp Med. 2004;199:1265-75 pubmed
    ..For the first time, these findings define a chemokine system for homeostatic T cell traffic in normal human skin. ..
  7. Ruprecht C, Gattorno M, Ferlito F, Gregorio A, Martini A, Lanzavecchia A, et al. Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia. J Exp Med. 2005;201:1793-803 pubmed
  8. Magnusson S, Karlsson K, Reimer J, Corbach Söhle S, Patel S, Richner J, et al. Matrix-M™ adjuvanted envelope protein vaccine protects against lethal lineage 1 and 2 West Nile virus infection in mice. Vaccine. 2014;32:800-8 pubmed publisher
    ..In summary, Matrix-M™ adjuvanted E protein elicited potent and durable immune responses that prevented lethal WNV infection, and thus is a promising vaccine candidate for humans. ..
  9. Scholl B, Bersinger N, Kuhn A, Mueller M. Correlation between symptoms of pain and peritoneal fluid inflammatory cytokine concentrations in endometriosis. Gynecol Endocrinol. 2009;25:701-6 pubmed publisher
    ..TNF-alpha and glycodelin may thus play a role in endometriosis and the severity of menstrual pain. ..
  10. Kopf M, Herren S, Wiles M, Pepys M, Kosco Vilbois M. Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component. J Exp Med. 1998;188:1895-906 pubmed
    ..These findings reveal that the germinal center produces and uses molecules of the innate immune system, evolutionarily pirating them in order to optimally generate high affinity antibody responses. ..
  11. Eriksson K, Cervantes Barragan L, Ludewig B, Thiel V. Mouse hepatitis virus liver pathology is dependent on ADP-ribose-1''-phosphatase, a viral function conserved in the alpha-like supergroup. J Virol. 2008;82:12325-34 pubmed publisher
    ..Collectively, our data demonstrate that the MHV X domain exacerbates MHV-induced liver pathology, most likely through the induction of excessive inflammatory cytokine expression. ..
  12. Brunner C, Kanellos T, Meli M, Sutton D, Gisler R, Gomes Keller M, et al. Antibody induction after combined application of an adjuvanted recombinant FeLV vaccine and a multivalent modified live virus vaccine with a chlamydial component. Vaccine. 2006;24:1838-46 pubmed
    ..felis but diminished for FPV. The use of these vaccines in combination was safe and will simplify vaccination schedules in veterinary practice. ..
  13. Ouaked N, Mantel P, Bassin C, Burgler S, Siegmund K, Akdis C, et al. Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1. J Immunol. 2009;182:1041-9 pubmed
    ..Our data demonstrate a molecular mechanism regulating FOXP3 expression, which is of considerable interest for the development of new drug targets aiming to support anti-inflammatory mechanisms of the immune system. ..
  14. De Feo D, Merlini A, Brambilla E, Ottoboni L, Laterza C, Menon R, et al. Neural precursor cell-secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity. J Clin Invest. 2017;127:3937-3953 pubmed publisher
    ..This study provides evidence that intrathecally transplanted NPCs interfere with the CNS-restricted inflammation of EAE by reprogramming infiltrating MCs into antiinflammatory myeloid cells via secretion of TGF-β2. ..
  15. Binder D, van den Broek M, Kagi D, Bluethmann H, Fehr J, Hengartner H, et al. Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus. J Exp Med. 1998;187:1903-20 pubmed
    ..Thus, in the absence of IFN-gamma and/or TNF/LT-alpha, exhaustion of virus-specific T cells was not hampered. ..
  16. Eriksson U, Kurrer M, Sonderegger I, Iezzi G, Tafuri A, Hunziker L, et al. Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis. J Exp Med. 2003;197:323-31 pubmed
    ..Thus, IL-1R1 triggering is required for efficient activation of dendritic cells, which is in turn a prerequisite for induction of autoreactive CD4(+) T cells and autoimmunity. ..
  17. Bertolo A, Thiede T, Aebli N, Baur M, Ferguson S, Stoyanov J. Human mesenchymal stem cell co-culture modulates the immunological properties of human intervertebral disc tissue fragments in vitro. Eur Spine J. 2011;20:592-603 pubmed publisher
    ..In conclusion, these data suggest that MSCs may modulate disc-specific inflammatory and pain status and aid regeneration of the host tissue. ..
  18. Feder Mengus C, Schultz Thater E, Oertli D, Marti W, Heberer M, Spagnoli G, et al. Nonreplicating recombinant vaccinia virus expressing CD40 ligand enhances APC capacity to stimulate specific CD4+ and CD8+ T cell responses. Hum Gene Ther. 2005;16:348-60 pubmed
    ..Such a recombinant vector might help bypass the requirement for activated helper cells during CTL priming, thus qualifying as a potentially relevant vector in the generation of CD8+ T cell responses in cancer immunotherapy. ..
  19. Hüsser L, Ruggli N, Summerfield A. N(pro) of classical swine fever virus prevents type I interferon-mediated priming of conventional dendritic cells for enhanced interferon-? response. J Interferon Cytokine Res. 2012;32:221-9 pubmed publisher
    ..These results indicate that CSFV has evolved to prevent type I IFN sensitization in infected cells through the action of the N(pro)...
  20. Rochford E, Sabaté Brescó M, Zeiter S, Kluge K, Poulsson A, Ziegler M, et al. Monitoring immune responses in a mouse model of fracture fixation with and without Staphylococcus aureus osteomyelitis. Bone. 2016;83:82-92 pubmed publisher
    ..A divergent local immune polarization is evident in the infected versus non-infected animals, with the immune response ultimately unable to clear the S. aureus infection. ..
  21. Ulmer A, Kaconis Y, Heinbockel L, Correa W, Alexander C, Rietschel E, et al. Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A. Innate Immun. 2016;22:168-80 pubmed publisher
    ..The fragmentation of the aggregates was an endothermic process, differing from a complex formation but rather typical for a catalytic reaction. ..
  22. Löhning M, Hegazy A, Pinschewer D, Busse D, Lang K, Hofer T, et al. Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors. J Exp Med. 2008;205:53-61 pubmed publisher
    ..These findings demonstrate the efficiency of linear memory T cell differentiation and encourage the design of vaccines and immune cell therapies based on differentiated effector T cells. ..
  23. Fotio A, Olleros M, Vesin D, Tauzin S, Bisig R, Dimo T, et al. In vitro inhibition of lipopolysaccharide and mycobacterium bovis bacillus Calmette Guérin-induced inflammatory cytokines and in vivo protection from D-galactosamine/LPS -mediated liver injury by the medicinal plant Sclerocarya birrea. Int J Immunopathol Pharmacol. 2010;23:61-72 pubmed
    ..Taken together, our data indicate that stem bark methanol extract of S. birrea possesses anti-inflammatory properties by inhibiting NF-kB activation and cytokine release induced by inflammatory or infectious stimuli. ..
  24. Meyer S, Woodward M, Hertel C, Vlaicu P, Haque Y, Kärner J, et al. AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies. Cell. 2016;166:582-595 pubmed publisher
    ..Thus, naturally occurring human autoantibodies may actively limit disease and be of therapeutic utility. ..
  25. Bosco D, Meda P, Morel P, Matthey Doret D, Caille D, Toso C, et al. Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells. Diabetologia. 2005;48:1523-33 pubmed
    ..Our results demonstrate that alpha1-PI is expressed by the alpha and delta cells of human islets, and that proinflammatory cytokines enhance the production and release of this inhibitor. ..
  26. Wawrzyniak M, Ochsner U, Wirz O, Wawrzyniak P, Van De Veen W, Akdis C, et al. A novel, dual cytokine-secretion assay for the purification of human Th22 cells that do not co-produce IL-17A. Allergy. 2016;71:47-57 pubmed publisher
    ..This technique may allow the purification of any single cytokine-producing cell subset, and the combination of several different cytokine secretion assays can be used to purify and characterize novel and unique cell subsets. ..
  27. Ronet C, Beverley S, Fasel N. Muco-cutaneous leishmaniasis in the New World: the ultimate subversion. Virulence. 2011;2:547-52 pubmed publisher
    ..The presence of LRV in Leishmania opens new perspectives not only in basic understanding of the intimate relation between the parasite and LRV, but also in understanding the importance of the inflammatory response in MCL patients...
  28. Biason Lauber A, Böni Schnetzler M, Hubbard B, Bouzakri K, Brunner A, Cavelti Weder C, et al. Identification of a SIRT1 mutation in a family with type 1 diabetes. Cell Metab. 2013;17:448-455 pubmed publisher
    ..These observations identify a role for SIRT1 in human autoimmunity and unveil a monogenic form of type 1 diabetes. ..
  29. Scharl M, Vavricka S, Rogler G. Review: new anti-cytokines for IBD: what is in the pipeline?. Curr Drug Targets. 2013;14:1405-20 pubmed
    ..Taken together a large number of new therapeutic anti-cytokine approaches are currently tested in clinical trials in IBD patients. In this review, the new therapeutic approaches for cytokine inhibition in IBD patients are discussed. ..
  30. Ehl S, Hombach J, Aichele P, Hengartner H, Zinkernagel R. Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. J Exp Med. 1997;185:1241-51 pubmed
    ..We conclude that although bystander activation via cytokines may generate cytolytically active CTL from naive precursors, quantitative considerations suggest that this is usually not of major biological consequence. ..
  31. Tan N, Michalik L, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor-beta as a target for wound healing drugs. Expert Opin Ther Targets. 2004;8:39-48 pubmed
    ..These novel insights into the orchestrating roles of PPARbeta during wound healing may be helpful in the development of drugs for acute and chronic wound disorders. ..
  32. Fujita H, Chalubinski M, Rhyner C, Indermitte P, Meyer N, Ferstl R, et al. Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects. J Allergy Clin Immunol. 2011;127:1612-21.e8 pubmed publisher
    ..These results demonstrate that claudin-1 might play a role in airway remodeling in asthmatic patients by means of regulation of ASM cell proliferation, angiogenesis, and inflammation. ..
  33. Walter A, Schafer M, Cecconi V, Matter C, Urosevic Maiwald M, Belloni B, et al. Aldara activates TLR7-independent immune defence. Nat Commun. 2013;4:1560 pubmed publisher
    ..Although it remains to be tested, it is possible that imiquimod-independent effects also contribute to the therapeutic efficacy of Aldara. ..
  34. Simon H, Weber M, Becker E, Zilberman Y, Blaser K, Levi Schaffer F. Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonist. J Immunol. 2000;165:4069-75 pubmed
    ..The cellular content of ECP appears to be a no limiting factor in the case of repetitive stimulation, implying that mature eosinophils may not require a significant ECP resynthesis. ..
  35. Maestroni G. Short exposure of maturing, bone marrow-derived dendritic cells to norepinephrine: impact on kinetics of cytokine production and Th development. J Neuroimmunol. 2002;129:106-14 pubmed
    ..Our results suggest that the extent of Th differentiation in the response to an antigen might be influenced by the local sympathetic nervous activity in the early phase of dendritic cell stimulation. ..
  36. Bansi J, Bloch W, Gamper U, Kesselring J. Training in MS: influence of two different endurance training protocols (aquatic versus overland) on cytokine and neurotrophin concentrations during three week randomized controlled trial. Mult Scler. 2013;19:613-21 pubmed publisher
    ..Cardiorespiratory values improved significantly over time within both groups. This study indicates that aquatic training activates BDNF regulation and can be an effective training method during rehabilitation in PwMS. ..
  37. Marsland B, Bättig P, Bauer M, Ruedl C, Lässing U, Beerli R, et al. CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity. 2005;22:493-505 pubmed
  38. Brattström A, Schapowal A, Kamal M, Maillet I, Ryffel B, Moser R. The plant extract Isatis tinctoria L. extract (ITE) inhibits allergen-induced airway inflammation and hyperreactivity in mice. Phytomedicine. 2010;17:551-6 pubmed publisher
    ..ITE, which has been reported inhibiting COX-2 and 5-LOX, reduced allergic airway inflammation and AHR by inhibiting the production of the Th2 cytokines IL-4 and IL-5, and RANTES. ..
  39. Nembrini C, Abel B, Kopf M, Marsland B. Strong TCR signaling, TLR ligands, and cytokine redundancies ensure robust development of type 1 effector T cells. J Immunol. 2006;176:7180-8 pubmed
    ..Our findings clarify the hierarchical requirements of the major IFN-gamma inducing pathways and highlight the important role TLR ligand-activated DCs have to preserve them. ..
  40. Giovanoli S, Engler H, Engler A, Richetto J, Voget M, Willi R, et al. Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice. Science. 2013;339:1095-9 pubmed publisher
  41. Abdelli S, Abderrahmani A, Hering B, Beckmann J, Bonny C. The c-Jun N-terminal kinase JNK participates in cytokine- and isolation stress-induced rat pancreatic islet apoptosis. Diabetologia. 2007;50:1660-9 pubmed
  42. McKinnon B, Bersinger N, Wotzkow C, Mueller M. Endometriosis-associated nerve fibers, peritoneal fluid cytokine concentrations, and pain in endometriotic lesions from different locations. Fertil Steril. 2012;97:373-80 pubmed publisher
    ..The presence of endometriosis-associated nerve fibers appear to be related to both the pain experienced by women with endometriosis and the concentration of PF cytokines; however, this association varies with the lesion location. ..
  43. Aguzzi A, Heikenwalder M. Prions, cytokines, and chemokines: a meeting in lymphoid organs. Immunity. 2005;22:145-54 pubmed
  44. Defaux A, Zurich M, Honegger P, Monnet Tschudi F. Inflammatory responses in aggregating rat brain cell cultures subjected to different demyelinating conditions. Brain Res. 2010;1353:213-24 pubmed publisher
    ..These findings indicate that each of the three demyelinating insults caused distinct patterns of demyelination and inflammatory reactivity, and that of the demyelinating agents tested only LPC exhibited general toxicity. ..
  45. Dummer R, Willers J, Kamarashev J, Urosevic M, Dobbeling U, Burg G. Pathogenesis of cutaneous lymphomas. Semin Cutan Med Surg. 2000;19:78-86 pubmed
    ..Newly identified molecular disturbances in cutaneous lymphomas might be targeted by specific molecular or immunologic interventions in the future. ..
  46. Taraborrelli C, Palchykova S, Tobler I, Gast H, Birchler T, Fontana A. TNFR1 is essential for CD40, but not for lipopolysaccharide-induced sickness behavior and clock gene dysregulation. Brain Behav Immun. 2011;25:434-42 pubmed publisher
    ..Thus, our results suggest that TNFR1 mediates SBS and dysregulation of clock genes in autoimmune diseases. ..
  47. Rüdiger J, Gencay M, Yang J, Bihl M, Tamm M, Roth M. Fast beneficial systemic anti-inflammatory effects of inhaled budesonide and formoterol on circulating lymphocytes in asthma. Respirology. 2013;18:840-7 pubmed publisher
    ..PHA-induced proliferation was reduced by both drugs alone and in combination. Combined budesonide and formoterol may reduce airway inflammation and immune reactivity of circulating lymphocytes through its local and systemic effects. ..
  48. Kania G, Blyszczuk P, Eriksson U. Mechanisms of cardiac fibrosis in inflammatory heart disease. Trends Cardiovasc Med. 2009;19:247-52 pubmed publisher
    ..In this minireview, we provide an update on these mechanisms and discuss their significance in pathologic remodeling and heart failure progression after myocarditis. ..
  49. Kaiser P, Hardt W. Salmonella typhimurium diarrhea: switching the mucosal epithelium from homeostasis to defense. Curr Opin Immunol. 2011;23:456-63 pubmed publisher
    ..Here, we focus on one particular model, the streptomycin pretreated mouse model for Salmonella diarrhea, to illustrate novel concepts in microbe-mucosa interaction, that is how this system switches from homeostasis to disease. ..
  50. Nirgianakis K, Bersinger N, McKinnon B, Kostov P, Imboden S, Mueller M. Regression of the inflammatory microenvironment of the peritoneal cavity in women with endometriosis by GnRHa treatment. Eur J Obstet Gynecol Reprod Biol. 2013;170:550-4 pubmed publisher
    ..To investigate the effect of gonadotropin-releasing hormone analogues (GnRHa) on the peritoneal fluid microenvironment in women with endometriosis...
  51. Meiler F, Zumkehr J, Klunker S, Rückert B, Akdis C, Akdis M. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med. 2008;205:2887-98 pubmed publisher
    ..Thus, rapid switch and expansion of IL-10-producing Tr1 cells and the use of multiple suppressive factors represent essential mechanisms in immune tolerance to a high dose of allergens in nonallergic individuals. ..
  52. Massacand J, Stettler R, Meier R, Humphreys N, Grencis R, Marsland B, et al. Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function. Proc Natl Acad Sci U S A. 2009;106:13968-73 pubmed publisher
    ..Taken together, our data show that the primary function of TSLP is to directly suppress IL-12 secretion, thus supporting Th2 immune responses...
  53. Monnet Tschudi F, Defaux A, Braissant O, Cagnon L, Zurich M. Methods to assess neuroinflammation. Curr Protoc Toxicol. 2011;Chapter 12:Unit12.19 pubmed publisher
  54. Bootz F, Neri D. Immunocytokines: a novel class of products for the treatment of chronic inflammation and autoimmune conditions. Drug Discov Today. 2016;21:180-189 pubmed publisher
    ..This review analyzes basic principles in the design of immunocytokines and describes the most advanced products in preclinical and clinical development. ..
  55. Meyer U, Murray P, Urwyler A, Yee B, Schedlowski M, Feldon J. Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling. Mol Psychiatry. 2008;13:208-21 pubmed
    ..Hence, shifts of the balance between pro- and anti-inflammatory cytokine classes may be a critical determinant of the final impact on neurodevelopment following early life infection or innate immune imbalances. ..
  56. Moransard M, Sawitzky M, Fontana A, Suter T. Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis. Glia. 2010;58:559-71 pubmed publisher
    ..Taken together, our data indicate a pro-inflammatory role for the HGF/c-met pathway in EAE rather than a role in the initiation of repair mechanisms. ..
  57. Akdis M. The cellular orchestra in skin allergy; are differences to lung and nose relevant?. Curr Opin Allergy Clin Immunol. 2010;10:443-51 pubmed publisher
    ..Better understanding and characterization of newly described effector cell subsets and their interaction between antigen presenting cells and resident tissue cells will enlighten our knowledge on the mechanisms of allergic diseases. ..
  58. Dür M, Steiner G, Stoffer M, Fialka Moser V, Kautzky Willer A, Dejaco C, et al. Initial evidence for the link between activities and health: Associations between a balance of activities, functioning and serum levels of cytokines and C-reactive protein. Psychoneuroendocrinology. 2016;65:138-48 pubmed publisher
    ..In conclusion, we found preliminary biological evidence for the link between occupation and health in that the concepts encompassed in the construct of occupational balance were associated with functioning, cytokines and CRP. ..
  59. Forssmann U, Uguccioni M, Loetscher P, Dahinden C, Langen H, Thelen M, et al. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. J Exp Med. 1997;185:2171-6 pubmed
  60. Uguccioni M, Mackay C, Ochensberger B, Loetscher P, Rhis S, LaRosa G, et al. High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. J Clin Invest. 1997;100:1137-43 pubmed
  61. Guillemot L, Schneider Y, Brun P, Castagliuolo I, Pizzuti D, Martines D, et al. Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. J Cell Sci. 2012;125:5005-14 pubmed publisher
  62. Maestroni G, Sulli A, Pizzorni C, Villaggio B, Cutolo M. Melatonin in rheumatoid arthritis: synovial macrophages show melatonin receptors. Ann N Y Acad Sci. 2002;966:271-5 pubmed
    ..Furthermore, melatonin is present in the synovial fluid of RA patients and synovial macrophages express a specific binding site. We suggest that melatonin may exert a disease-promoting role in RA. ..
  63. Pagano A, Métrailler Ruchonnet I, Aurrand Lions M, Lucattelli M, Donati Y, Argiroffo C. Poly(ADP-ribose) polymerase-1 (PARP-1) controls lung cell proliferation and repair after hyperoxia-induced lung damage. Am J Physiol Lung Cell Mol Physiol. 2007;293:L619-29 pubmed
    ..Altogether, these results reveal an essential role of PARP-1 in the control of cell repair and tissue remodeling after hyperoxia-induced lung injury. ..
  64. Kovacs E, Link S, Toffol Schmidt U. Comparison of Viscum album QuFrF extract with vincristine in an in vitro model of human B cell lymphoma WSU-1. Arzneimittelforschung. 2008;58:592-7 pubmed publisher
    ..As parameters were measured: proliferation, viability, apoptosis/necrosis, IL-6 production, DNA synthesis and the cell cycle phases of the lymphoma cells at various time points...
  65. Pacheco López G, Giovanoli S, Langhans W, Meyer U. Priming of metabolic dysfunctions by prenatal immune activation in mice: relevance to schizophrenia. Schizophr Bull. 2013;39:319-29 pubmed publisher
  66. Lannes N, Summerfield A. Regulation of porcine plasmacytoid dendritic cells by cytokines. PLoS ONE. 2013;8:e60893 pubmed publisher
  67. Daigle I, Yousefi S, Colonna M, Green D, Simon H. Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. Nat Med. 2002;8:61-7 pubmed
    ..Thus, we provide molecular and functional evidence for negative signaling by death receptors. ..
  68. Zuercher A, Imboden M, Jampen S, Bosse D, Ulrich M, Chtioui H, et al. Cellular immunity in healthy volunteers treated with an octavalent conjugate Pseudomonas aeruginosa vaccine. Clin Exp Immunol. 2006;143:132-8 pubmed
    ..Therefore, confirmatory analyses in immunized CF patients with and without chronic infection with P. aeruginosa are foreseen. ..
  69. Wymann M, Schneiter R. Lipid signalling in disease. Nat Rev Mol Cell Biol. 2008;9:162-76 pubmed publisher
  70. Lorusso G, Ruegg C. The tumor microenvironment and its contribution to tumor evolution toward metastasis. Histochem Cell Biol. 2008;130:1091-103 pubmed publisher
  71. Eisele P, Salatino S, Sobek J, Hottiger M, Handschin C. The peroxisome proliferator-activated receptor ? coactivator 1?/? (PGC-1) coactivators repress the transcriptional activity of NF-?B in skeletal muscle cells. J Biol Chem. 2013;288:2246-60 pubmed publisher
    ..The PGC-1s therefore represent attractive targets to not only improve metabolic health in diseases like type 2 diabetes but also to limit the detrimental, low-grade inflammation in these patients. ..
  72. Bernier J. Immuno-oncology: Allying forces of radio- and immuno-therapy to enhance cancer cell killing. Crit Rev Oncol Hematol. 2016;108:97-108 pubmed publisher
  73. Dobbelaere D, Heussler V. Transformation of leukocytes by Theileria parva and T. annulata. Annu Rev Microbiol. 1999;53:1-42 pubmed
    ..This, in turn, leads to the activation of transcription factors, including nuclear factor-kappa B, which appear to be essential for the survival of Theileria-transformed T cells...
  74. Schaerli P, Willimann K, Lang A, Lipp M, Loetscher P, Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med. 2000;192:1553-62 pubmed
    ..These properties portray CXCR5(+) T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (T(FH)). ..
  75. Dai W, Waldvogel A, Siles Lucas M, Gottstein B. Echinococcus multilocularis proliferation in mice and respective parasite 14-3-3 gene expression is mainly controlled by an alphabeta CD4 T-cell-mediated immune response. Immunology. 2004;112:481-8 pubmed
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