Genomes and Genes
Experts and Doctors on cyclophilins in United States
Locale: United States
- Novgorodov S, Gudz T, Obeid L. Long-chain ceramide is a potent inhibitor of the mitochondrial permeability transition pore. J Biol Chem. 2008;283:24707-17 pubmed publisher..These results suggest a novel mechanism of ceramide regulation of mitochondrial function. ..
- Guo L, Du H, Yan S, Wu X, McKhann G, Chen J, et al. Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neurons. PLoS ONE. 2013;8:e54914 pubmed publisher..These findings provide new insights into CypD-dependent mitochondrial mPTP and signaling on mitochondrial trafficking in axons and synaptic degeneration in an environment enriched for A?. ..
- Boudko S, Ishikawa Y, Lerch T, Nix J, Chapman M, Bachinger H. Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse. BMC Res Notes. 2012;5:626 pubmed publisher..Instead, it locally rearranges the flexible N-terminal end of the polypeptide chain and also makes it more rigid. Interactions of the mutated cyclophilin B with a set of endoplasmic reticulum-resident proteins must be affected. ..
- Choi J, Sutor S, Lindquist L, Evans G, Madden B, Bergen H, et al. Severe osteogenesis imperfecta in cyclophilin B-deficient mice. PLoS Genet. 2009;5:e1000750 pubmed publisher..These data provide significant new mechanistic insight into the pathophysiology of OI and reveal how the members of the P3H1/CRTAP/CypB complex interact to direct proper formation of collagen and bone. ..
- Ishikawa Y, Vranka J, Boudko S, Pokidysheva E, Mizuno K, Zientek K, et al. Mutation in cyclophilin B that causes hyperelastosis cutis in American Quarter Horse does not affect peptidylprolyl cis-trans isomerase activity but shows altered cyclophilin B-protein interactions and affects collagen folding. J Biol Chem. 2012;287:22253-65 pubmed publisher
- Lorenson M, Ueda E, Chen K, Walker A. A major prolactin-binding complex on human milk fat globule membranes contains cyclophilins A and B: the complex is not the prolactin receptor. Am J Physiol Endocrinol Metab. 2012;302:E585-94 pubmed publisher..This is the first report of a unique, multicomponent, high-capacity milk fat reservoir of hPRL; all other analyses of milk PRL have utilized defatted milk. ..
- Ishikawa Y, Bachinger H. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1·cartilage-associated protein·cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. J Biol Chem. 2013;288:31437-46 pubmed publisher..We have tested the enzyme activities on model substrates in vitro using a GCRALCG peptide and the P3H1 complex. Our results suggest that this complex could function as a disulfide isomerase in the rough endoplasmic reticulum. ..
- Barsukova A, Bourdette D, Forte M. Mitochondrial calcium and its regulation in neurodegeneration induced by oxidative stress. Eur J Neurosci. 2011;34:437-47 pubmed publisher..The study offers a first insight into the mechanism underlying CyPD-dependent neuroprotection during oxidative stress. ..
- Mendu V, Chiu M, Barajas D, Li Z, Nagy P. Cpr1 cyclophilin and Ess1 parvulin prolyl isomerases interact with the tombusvirus replication protein and inhibit viral replication in yeast model host. Virology. 2010;406:342-51 pubmed publisher..We also show that the Ess1p parvulin prolyl isomerase partly complements Cpr1p function as an inhibitor of tombusvirus replication...
- Kovalev N, Nagy P. Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly. J Virol. 2013;87:13330-42 pubmed publisher..Overall, the current work has revealed a regulatory role for the cytosolic single-domain Cpr1-like cyclophilins in RNA virus replication...
- Hofer T, Servais S, Seo A, Marzetti E, Hiona A, Upadhyay S, et al. Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction. Mech Ageing Dev. 2009;130:297-307 pubmed publisher..In summary, the age-related reduction of Ca(2+) retention capacity in IFM may explain the increased susceptibility to stress-induced cell death in the aged myocardium...
- Rhoads M, Meyer J, Kolath S, Lamberson W, Lucy M. Growth hormone receptor, insulin-like growth factor (IGF)-1, and IGF-binding protein-2 expression in the reproductive tissues of early postpartum dairy cows. J Dairy Sci. 2008;91:1802-13 pubmed publisher..Differences between cows (independent of their BCS and milk production) accounted for a major portion of the variation that we observed. ..
- Liao D, Jin Z, Baas A, Daum G, Gygi S, Aebersold R, et al. Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells. J Biol Chem. 2000;275:189-96 pubmed..These results show that brief oxidative stress causes sustained release of protein factors from VSMC that can stimulate ERK1/2. These factors may be important mediators for the effects of reactive oxygen species on vascular function. ..
- Atapattu D, Albrecht R, McClenahan D, Czuprynski C. Dynamin-2-dependent targeting of mannheimia haemolytica leukotoxin to mitochondrial cyclophilin D in bovine lymphoblastoid cells. Infect Immun. 2008;76:5357-65 pubmed publisher..The results of this study show that LKT trafficking and LKT-mediated cell death involve dynamin-2 and cyclophilin D, in a process that can be prevented by the mitochondrial membrane-protecting function of CSA...
- Ramachandran A, Lebofsky M, Baines C, Lemasters J, Jaeschke H. Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury. Free Radic Res. 2011;45:156-64 pubmed publisher..Thus, mitochondrial oxidative stress and induction of the MPT are critical events in APAP hepatotoxicity in vivo and at least part of the APAP-induced oxidant stress and peroxynitrite formation occurs downstream of the MPT. ..
- Choi J, Schroeder M, Sarkaria J, Bram R. Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells. Cancer Res. 2014;74:484-96 pubmed publisher..Our findings link chaperone-mediated protein folding in the ER to mechanisms underlying oncogenic transformation, and they make CypB an attractive and immediately targetable molecule for glioblastoma multiforme therapy. ..
- Johnson J, Toft D. A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23. J Biol Chem. 1994;269:24989-93 pubmed
- Eliseev R, Malecki J, Lester T, Zhang Y, Humphrey J, Gunter T. Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect. J Biol Chem. 2009;284:9692-9 pubmed publisher..The fact that some tumors overexpress CypD suggests that this may be an additional mechanism of suppression of apoptosis in cancer. ..
- Naga K, Sullivan P, Geddes J. High cyclophilin D content of synaptic mitochondria results in increased vulnerability to permeability transition. J Neurosci. 2007;27:7469-75 pubmed..The high levels of cyclophilin D in neuronal mitochondria result in their greater vulnerability to mPT and in higher levels of cyclosporine A being required to inhibit mPTP opening. ..
- Forte M, Gold B, Marracci G, Chaudhary P, Basso E, Johnsen D, et al. Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Proc Natl Acad Sci U S A. 2007;104:7558-63 pubmed..Our results directly implicate pathological activation of the mitochondrial PTP in the axonal damage occurring during MS and identify CyPD, as well as the PTP, as a potential target for MS neuroprotective therapies. ..
- Lin J, Mendu V, Pogany J, Qin J, Nagy P. The TPR domain in the host Cyp40-like cyclophilin binds to the viral replication protein and inhibits the assembly of the tombusviral replicase. PLoS Pathog. 2012;8:e1002491 pubmed publisher..Overall, the current work revealed a role for Cyp40-like proteins and their TPR domains as regulators of RNA virus replication. ..
- Oses Prieto J, Bengoechea Alonso M, Artigues A, Iriarte A, Martinez Carrion M. The nature of the rate-limiting steps in the refolding of the cofactor-dependent protein aspartate aminotransferase. J Biol Chem. 2003;278:49988-99 pubmed..These results suggest that proline isomerization may not be the only factor determining the slow refolding of this cofactor-dependent protein. ..
- Xia Z, Anderson M, Diaz M, Zeleznik Le N. MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein. Proc Natl Acad Sci U S A. 2003;100:8342-7 pubmed..Furthermore, repression mediated by histone deacetylases and that mediated by polycomb group proteins may act either independently or together for MLL function in vivo. ..
- Kulkarni M, Karafova A, Kamysz W, Schenkman S, Pelle R, McGwire B. Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces parasite calcineurin activation and infectivity. J Biol Chem. 2013;288:8772-84 pubmed publisher..This work demonstrates that cyclophilin serves as molecular sensor leading to the evasion and adaptive metabolic response to insect defense peptides. ..
- Komers R, Mar D, Denisenko O, Xu B, Oyama T, Bomsztyk K. Epigenetic changes in renal genes dysregulated in mouse and rat models of type 1 diabetes. Lab Invest. 2013;93:543-52 pubmed publisher..This pattern could contribute to diabetes-mediated transitions in chromatin that facilitate transcriptional changes in the diabetic kidney. ..
- Homan E, Lietman C, Grafe I, Lennington J, Morello R, Napierala D, et al. Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues. PLoS Genet. 2014;10:e1004121 pubmed publisher..Our observations suggest differential tissue consequences due to selective inactivation of P3H1 hydroxylase activity versus complete ablation of the prolyl 3-hydroxylation complex. ..
- Anderson M, Fair K, Amero S, Nelson S, Harte P, Diaz M. A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells. Dev Genes Evol. 2002;212:107-13 pubmed..Over expression of Dcyp33 in DrosophilaSL1 cells results in down-regulation of AbdominalB Hoxgene expression, mirroring the effect of human Cyp33 on the expression of human HOXgenes. ..
- Ishikawa Y, Mizuno K, Bachinger H. Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline. J Biol Chem. 2017;292:9273-9282 pubmed publisher..Therefore, we propose that hydroxyproline modulates the rate of Ziploc-ing of the triple helix of collagen in the rER. ..
- Su K, Savino C, Marracci G, Chaudhary P, Yu X, Morris B, et al. Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis. Eur J Neurosci. 2012;35:562-71 pubmed publisher..These results confirm the critical role of ROS-mediated mitochondrial dysfunction in the axonal loss that accompanies EAE, and identify p66 as a new pharmacologic target for MS neuroprotective therapeutics...
- Nagy P, Wang R, Pogany J, Hafren A, Makinen K. Emerging picture of host chaperone and cyclophilin roles in RNA virus replication. Virology. 2011;411:374-82 pubmed publisher..This review also discusses the emerging roles of cyclophilins, which are peptidyl-prolyl isomerases with chaperone functions, in replication of selected (+)RNA viruses. ..
- Aulik N, Hellenbrand K, Kisiela D, Czuprynski C. Mannheimia haemolytica leukotoxin binds cyclophilin D on bovine neutrophil mitochondria. Microb Pathog. 2011;50:168-78 pubmed publisher..These data confirm that LKT binds to bovine neutrophil mitochondria, but indicate there are distinctions between neutrophil and BL-3 mitochondria that might reflect differences in cyclophilin D...
- Fernandes F, Ansari I, Striker R. Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A. PLoS ONE. 2010;5:e9815 pubmed publisher..Collectively, this data suggests direct interactions between cyclophilins and NS5A are critical to understand for optimal use of cyclophilin inhibitors in anti-HCV therapy...
- Ishikawa Y, Wirz J, Vranka J, Nagata K, Bachinger H. Biochemical characterization of the prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B complex. J Biol Chem. 2009;284:17641-7 pubmed publisher..The P3H1.CRTAP.CypB complex also delayed the in vitro fibril formation of type I collagen, indicating that this complex is also able to interact with triple helical collagen and acts as a collagen chaperone. ..