Experts and Doctors on cyclic peptides in Sweden


Locale: Sweden
Topic: cyclic peptides

Top Publications

  1. Stolt P, Yahya A, Bengtsson C, Kallberg H, Ronnelid J, Lundberg I, et al. Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis. Ann Rheum Dis. 2010;69:1072-6 pubmed publisher
    ..95)). Silica exposure combined with smoking among men is associated with an increased risk of developing ACPA-positive RA. These results suggest that different inhalation exposures may interact in the aetiology of ACPA-positive RA. ..
  2. Rantapaa Dahlqvist S. What happens before the onset of rheumatoid arthritis?. Curr Opin Rheumatol. 2009;21:272-8 pubmed publisher
    ..Soluble immunological markers are also increased closer to the onset of symptoms indicating activation of the immune system. ..
  3. Kokkonen H, Johansson M, Innala L, Jidell E, Rantapaa Dahlqvist S. The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden. Arthritis Res Ther. 2007;9:R56 pubmed
    ..05 and P < 0.01, respectively), while the combination of both resulted in an even earlier age at onset. Smoking was identified as a risk factor independent of the 1858T variant and anti-CCP antibodies. ..
  4. Andersson H, Demaegdt H, Vauquelin G, Lindeberg G, Karlen A, Hallberg M, et al. Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP). J Med Chem. 2010;53:8059-71 pubmed publisher
    ..3 and 5.2 nM, respectively. ..
  5. Reinikainen M, Meriluoto J, Spoof L, Harada K. The toxicities of a polyunsaturated fatty acid and a microcystin to Daphnia magna. Environ Toxicol. 2001;16:444-8 pubmed
    ..The activity equaled that of microcystin-LR, which is commonly treated as one of the most potent cyanobacterial toxins. Our results suggest that the toxic properties of PUFAs deserve more attention. ..
  6. Lindberg M, Tångrot J, Oliveberg M. Complete change of the protein folding transition state upon circular permutation. Nat Struct Biol. 2002;9:818-22 pubmed
    ..The observations indicate that the diffuse transition state of S6 is not required for folding but could be an evolutionary development to optimize cooperativity. ..
  7. Svärd A, Kastbom A, Reckner Olsson A, Skogh T. Presence and utility of IgA-class antibodies to cyclic citrullinated peptides in early rheumatoid arthritis: the Swedish TIRA project. Arthritis Res Ther. 2008;10:R75 pubmed publisher
    ..Although IgA anti-CCP analysis does not seem to offer any diagnostic information in addition to IgG anti-CCP analysis, further efforts are justified to investigate the prognostic implications. ..
  8. Bohm F, Pernow J, Lindström J, Ahlborg G. ETA receptors mediate vasoconstriction, whereas ETB receptors clear endothelin-1 in the splanchnic and renal circulation of healthy men. Clin Sci (Lond). 2003;104:143-51 pubmed
    ..The ET(B) receptor seems to function as a clearance receptor and may modulate vascular tone by altering the plasma concentration of ET-1. ..
  9. Wikberg J, Mutulis F. Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction. Nat Rev Drug Discov. 2008;7:307-23 pubmed publisher
    ..Given the complexity of the melanocortin system, we also highlight the challenges and opportunities for future drug discovery in this area. ..

More Information


  1. Pohanka A, Menkis A, Levenfors J, Broberg A. Low-abundance kutznerides from Kutzneria sp. 744. J Nat Prod. 2006;69:1776-81 pubmed
    ..The trichlorinated 2 and 8 showed the highest antimicrobial activity, whereas 6, with a hydroxylated piperazic acid unit, did not show any inhibition of the pathogens at 230 microM. ..
  2. Nitescu N, Grimberg E, Ricksten S, Herlitz H, Guron G. Endothelin B receptors preserve renal blood flow in a normotensive model of endotoxin-induced acute kidney dysfunction. Shock. 2008;29:402-9 pubmed
    ..05]) in BQ-123-treated rats but did not significantly influence MAP in other groups. We conclude that in early normotensive endotoxemia, ETB receptors exert a renal vasodilator influence and contribute to maintain normal RBF. ..
  3. Axén A, Lindeberg G, Demaegdt H, Vauquelin G, Karlen A, Hallberg M. Cyclic insulin-regulated aminopeptidase (IRAP)/AT4 receptor ligands. J Pept Sci. 2006;12:705-13 pubmed
    ..The cyclic constrained analogs allowed us to propose a tentative bioactive conformation of angiotensin IV and it seems that the peptide adopts an inverse gamma-turn at the C-terminal. ..
  4. Ahlborg G, Lindström J. Insulin sensitivity and big ET-1 conversion to ET-1 after ETA- or ETB-receptor blockade in humans. J Appl Physiol (1985). 2002;93:2112-21 pubmed
    ..In conclusion, ET-1-induced reduction in insulin sensitivity and clearance as well as splanchnic and renal vasoconstriction are ET(A) mediated. ET(A)-receptor stimulation seems to inhibit the conversion of big ET-1 to ET-1. ..
  5. Goransson U, Sjögren M, Svangård E, Claeson P, Bohlin L. Reversible antifouling effect of the cyclotide cycloviolacin O2 against barnacles. J Nat Prod. 2004;67:1287-90 pubmed
    ..Cycloviolacin O2 was isolated from the terrestrial plant Viola odorata by strong cation exchange and reversed-phase HPLC and identified by mass spectrometry following aminoethylation and enzymatic cleavage...
  6. Hedner E, Sjögren M, Hodzic S, Andersson R, Goransson U, Jonsson P, et al. Antifouling activity of a dibrominated cyclopeptide from the marine sponge Geodia barretti. J Nat Prod. 2008;71:330-3 pubmed publisher
    ..barretti and which displays settlement inhibition of barnacle larvae ( Balanus improvisus) with an EC 50 value of 15 nM. The chemical structure was determined using MS and 2D-NMR...
  7. Björkqvist M, Bernsand M, Eliasson L, Hakanson R, Lindstrom E. Somatostatin, misoprostol and galanin inhibit gastrin- and PACAP-stimulated secretion of histamine and pancreastatin from ECL cells by blocking specific Ca2+ channels. Regul Pept. 2005;130:81-90 pubmed
  8. Granstam E, Granstam S, Fellstrom B, Lind L. Endothelium-dependent vasodilation in the uvea of hypertensive and normotensive rats. Curr Eye Res. 1998;17:189-96 pubmed
  9. Albinsson S, Nordström I, Hellstrand P. Stretch of the vascular wall induces smooth muscle differentiation by promoting actin polymerization. J Biol Chem. 2004;279:34849-55 pubmed
    ..The effect is partially, but probably not completely, mediated via Rho-associated kinase and cofilin downstream of Rho. ..
  10. Svangård E, Goransson U, Smith D, Verma C, Backlund A, Bohlin L, et al. Primary and 3-D modelled structures of two cyclotides from Viola odorata. Phytochemistry. 2003;64:135-42 pubmed
    ..The images of vodo M and vodo N show amphipathic structures with considerable surface hydrophobicity for a protein modelled in a polar environment...
  11. Goransson U, Broussalis A, Claeson P. Expression of Viola cyclotides by liquid chromatography-mass spectrometry and tandem mass spectrometry sequencing of intercysteine loops after introduction of charges and cleavage sites by aminoethylation. Anal Biochem. 2003;318:107-17 pubmed
    ..The strategy for converting conserved cysteines to enzymatic cleavage sites might also benefit the study of other peptides and proteins displaying similar structural problems for MS analysis...
  12. Cejvan K, Coy D, Efendic S. Intra-islet somatostatin regulates glucagon release via type 2 somatostatin receptors in rats. Diabetes. 2003;52:1176-81 pubmed
    ..In the two latter experimental systems, DC-41-33 had no significant effect on insulin release. In conclusion, our results strongly support the hypothesis that islet SST inhibits glucagon secretion via a local action. ..
  13. Lindholm P, Goransson U, Johansson S, Claeson P, Gullbo J, Larsson R, et al. Cyclotides: a novel type of cytotoxic agents. Mol Cancer Ther. 2002;1:365-9 pubmed
    ..This, together with the exceptional chemical and biological stability of cyclotides, makes them interesting in particular for their potential as pharmacological tools and possibly as leads to antitumor agents...
  14. Prusis P, Schioth H, Muceniece R, Herzyk P, Afshar M, Hubbard R, et al. Modeling of the three-dimensional structure of the human melanocortin 1 receptor, using an automated method and docking of a rigid cyclic melanocyte-stimulating hormone core peptide. J Mol Graph Model. 1997;15:307-17, 334 pubmed