Experts and Doctors on cultured cells in Germany

Summary

Locale: Germany
Topic: cultured cells

Top Publications

  1. Zou Y, Muller W, Gu H, Rajewsky K. Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies. Curr Biol. 1994;4:1099-103 pubmed
    ..Cre-loxP-mediated gene replacement is a simple and efficient general method of targeted mutagenesis in the mouse. ..
  2. Kleene R, Dartsch H, Kern H. The secretory lectin ZG16p mediates sorting of enzyme proteins to the zymogen granule membrane in pancreatic acinar cells. Eur J Cell Biol. 1999;78:79-90 pubmed
    ..We conclude that ZG16p may act as a linker molecule between the submembranous matrix on the luminal side of ZGM and aggregated secretory proteins during granule formation in the TGN. ..
  3. Ernsberger U, Reissmann E, Mason I, Rohrer H. The expression of dopamine beta-hydroxylase, tyrosine hydroxylase, and Phox2 transcription factors in sympathetic neurons: evidence for common regulation during noradrenergic induction and diverging regulation later in development. Mech Dev. 2000;92:169-77 pubmed
    ..The time course of Phox2a and 2b expression suggests an evolutionary conserved role in noradrenergic induction. In addition, Phox2a, Phox2b, and c-ret may be involved in the differentiation of cholinergic sympathetic neurons. ..
  4. Schroder R, Fürst D, Klasen C, Reimann J, Herrmann H, van der Ven P. Association of plectin with Z-discs is a prerequisite for the formation of the intermyofibrillar desmin cytoskeleton. Lab Invest. 2000;80:455-64 pubmed
    ..We conclude that the association of plectin with Z-discs is an early event in the lateral alignment of myofibrils that precedes the formation of the intermyofibrillar desmin cytoskeleton. ..
  5. Franzen R, Pautz A, Bräutigam L, Geisslinger G, Pfeilschifter J, Huwiler A. Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells. J Biol Chem. 2001;276:35382-9 pubmed
    ..Neutral ceramidase may thus represent a novel cytoprotective enzyme for mesangial cells exposed to inflammatory stress conditions. ..
  6. Pirlich M, Müller C, Sandig G, Jakstadt M, Sitte N, Lochs H, et al. Increased proteolysis after single-dose exposure with hepatotoxins in HepG2 cells. Free Radic Biol Med. 2002;33:283-91 pubmed
    ..In conclusion single-dose exposure with ethanol or haloalkanes causes increased protein oxidation followed by an increased proteasome-dependent protein degradation in human liver cells. ..
  7. van Zandbergen G, Hermann N, Laufs H, Solbach W, Laskay T. Leishmania promastigotes release a granulocyte chemotactic factor and induce interleukin-8 release but inhibit gamma interferon-inducible protein 10 production by neutrophil granulocytes. Infect Immun. 2002;70:4177-84 pubmed
    ..On the other hand, the inhibition of IP-10 production can lead to prevention of NK cell activation. ..
  8. Kusov Y, Gosert R, Gauss Muller V. Replication and in vivo repair of the hepatitis A virus genome lacking the poly(A) tail. J Gen Virol. 2005;86:1363-8 pubmed
    ..These data suggest that the 3' poly(A) tail of HAV can be restored with the help of a cellular and/or viral function that is regulated during the cell cycle. ..
  9. Storre J, Schäfer A, Reichert N, Barbero J, Hauser S, Eilers M, et al. Silencing of the meiotic genes SMC1beta and STAG3 in somatic cells by E2F6. J Biol Chem. 2005;280:41380-6 pubmed
    ..Our findings suggest a molecular mechanism for the stable transcriptional silencing of meiotic genes in somatic cells by E2F6. ..

More Information

Publications245 found, 100 shown here

  1. Gärtner D, Hoff H, Gimsa U, Burmester G, Brunner Weinzierl M. CD25 regulatory T cells determine secondary but not primary remission in EAE: impact on long-term disease progression. J Neuroimmunol. 2006;172:73-84 pubmed
    ..These results indicate that the cellular composition during first attack of MS predicts long-term disease progression. ..
  2. Neuhaus P, Jaschinsky B, Schneider S, Neuhaus H, Wolter A, Ebelt H, et al. Overexpression of Kelch domain containing-2 (mKlhdc2) inhibits differentiation and directed migration of C2C12 myoblasts. Exp Cell Res. 2006;312:3049-59 pubmed
    ..Our results suggest that a tightly controlled expression of mKlhdc2 is essential for a faithful execution of the myogenic differentiation and migration program. ..
  3. Weinmann L, Wischhusen J, Demma M, Naumann U, Roth P, Dasmahapatra B, et al. A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ. 2008;15:718-29 pubmed publisher
    ..0 are sensitive to siRNA-mediated downregulation of p53. Thus this new p53 rescue compound may open up novel perspectives for the treatment of cancers currently considered resistant to the therapeutic induction of apoptosis. ..
  4. Milenkovic V, Brockmann M, Meyer C, Desch M, Schweda F, Kurtz A, et al. Regulation of the renin expression in the retinal pigment epithelium by systemic stimuli. Am J Physiol Renal Physiol. 2010;299:F396-403 pubmed publisher
    ..In summary, we conclude that the renin expression in cells of the blood/retina barrier is influenced by the systemic RAS. ANG II circulating in the plasma is likely a mediator of this influence. ..
  5. Willbold E, Layer P. Butyrylcholinesterase regulates laminar retinogenesis of the chick embryo in vitro. Eur J Cell Biol. 1994;64:192-9 pubmed
    ..Moreover, AChE is almost fully diminished in these areas. The results further demonstrate novel roles of cholinesterases during laminar histogenesis of coherent neural networks in vitro. ..
  6. Plenz G, Kugler S, Schnittger S, Rieder H, Fonatsch C, Muller P. The human vigilin gene: identification, chromosomal localization and expression pattern. Hum Genet. 1994;93:575-82 pubmed
    ..4 kb is transcribed from the human vigilin gene. In accordance with previous observations on chicken mRNA, the expression of the human vigilin mRNA depends on the stage of cytodifferentiation both in vitro and in situ. ..
  7. Lechmann M, Krooshoop D, Dudziak D, Kremmer E, Kuhnt C, Figdor C, et al. The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells. J Exp Med. 2001;194:1813-21 pubmed
    ..This is the first report regarding functional aspects of CD83 and the binding of CD83 to DCs. ..
  8. Goldmann T, Wiedorn K, Kuhl H, Olert J, Branscheid D, Pechkovsky D, et al. Assessment of transcriptional gene activity in situ by application of HOPE-fixed, paraffin-embedded tissues. Pathol Res Pract. 2002;198:91-5 pubmed
    ..To sum up, these initial results, obtained with the novel HOPE-fixative, are promising as regards the enhancement of the capabilities of in situ hybridization in the future. ..
  9. May A, Kälsch T, Massberg S, Herouy Y, Schmidt R, Gawaz M. Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells. Circulation. 2002;106:2111-7 pubmed
    ..Effective anti-GP IIb/IIIa or anti-CD40L strategies might, therefore, contribute to plaque stabilization. ..
  10. Hofbauer K, Gess B, Lohaus C, Meyer H, Katschinski D, Kurtz A. Oxygen tension regulates the expression of a group of procollagen hydroxylases. Eur J Biochem. 2003;270:4515-22 pubmed
    ..Strong indirect evidence, moreover, suggests that the expression of these enzymes during hypoxia is coordinated by HIF-1. ..
  11. Samnick S, Scheuer C, Münks S, El Gibaly A, Menger M, Kirsch C. Technetium-99m labeled 1-(4-fluorobenzyl)-4-(2-mercapto-2-methyl-4-azapentyl)-4-(2-mercapto-2-methylpropylamino)-piperidine and iodine-123 metaiodobenzylguanidine for studying cardiac adrenergic function: a comparison of the uptake characteristics in. Nucl Med Biol. 2004;31:511-22 pubmed
    ..These data indicate that (99m)Tc-FBPBAT, like (123)I-MIBG, may be suitable for mapping cardiac adrenergic innervation by SPET, especially for alpha(1)/beta(1)-adrenoceptors as target in numerous heart diseases. ..
  12. Wu Y, Adam S, Hamann L, Heine H, Ulmer A, Buwitt Beckmann U, et al. Accumulation of inhibitory kappaB-alpha as a mechanism contributing to the anti-inflammatory effects of surfactant protein-A. Am J Respir Cell Mol Biol. 2004;31:587-94 pubmed
    ..The data suggest that anti-inflammatory effects of SP-A on LPS-challenged AMs are associated with a SP-A-mediated direct modulation of the IkappaB-alpha turnover in these cells. ..
  13. Pawlak J, Karolczak M, Krust A, Chambon P, Beyer C. Estrogen receptor-alpha is associated with the plasma membrane of astrocytes and coupled to the MAP/Src-kinase pathway. Glia. 2005;50:270-5 pubmed
    ..The physiological consequence of this phenomenon is not yet understood, but it might have a pivotal role in estrogen-mediated protective effects on midbrain dopamine neurons. ..
  14. Gärtner A, Polnau D, Staiger V, Sciarretta C, Minichiello L, Thoenen H, et al. Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling. J Neurosci. 2006;26:3496-504 pubmed
    ..Blockade of presynaptic or postsynaptic signaling alone did not result in a significant reduction of LTP. ..
  15. Mohamed S, Hanke T, Erasmi A, Bechtel M, Scharfschwerdt M, Meissner C, et al. Mitochondrial DNA deletions and the aging heart. Exp Gerontol. 2006;41:508-17 pubmed
    ..Since, apoptosis was induced by the mitochondria-mediated pathway only in transformed cells, the role for apoptosis in normal tissue of the aging heart remains unclear. ..
  16. Bartz H, Avalos N, Baetz A, Heeg K, Dalpke A. Involvement of suppressors of cytokine signaling in toll-like receptor-mediated block of dendritic cell differentiation. Blood. 2006;108:4102-8 pubmed
    ..The results indicate that TLR stimulation during the period of DC generation interferes with and deviates DC differentiation and that these effects are mediated particularly by SOCS-1. ..
  17. Sano T, Becker D, Ivashikina N, Wegner L, Zimmermann U, Roelfsema M, et al. Plant cells must pass a K+ threshold to re-enter the cell cycle. Plant J. 2007;50:401-13 pubmed publisher
    ..Based on these findings, turgor regulation through modulation of K(+) channel density in plant cell division and cell-cycle progression is discussed...
  18. Steinkamp Fenske K, Bollinger L, Völler N, Xu H, Yao Y, Bauer R, et al. Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. Atherosclerosis. 2007;195:e104-11 pubmed
    ..This in turn could mediate some of the beneficial effects of danshen. Ursolic acid is a prototypical compound responsible for this effect of the plant. ..
  19. Gressner O, Lahme B, Demirci I, Gressner A, Weiskirchen R. Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes. J Hepatol. 2007;47:699-710 pubmed
    ..The results do not reveal a relevant interrelation between TGF-beta function and CTGF/CCN2 expression in hepatic stellate cells, which is in contrast to hepatocytes. ..
  20. Schroeder P, Popp R, Wiegand B, Altschmied J, Haendeler J. Nuclear redox-signaling is essential for apoptosis inhibition in endothelial cells--important role for nuclear thioredoxin-1. Arterioscler Thromb Vasc Biol. 2007;27:2325-31 pubmed
    ..H2O2-induced nuclear import of Trx depends on karyopherin-alpha and NO. Trx-dependent induction of GST-P1 expression is required for apoptosis inhibition in endothelial cells. ..
  21. Vag T, Schramm T, Kaiser W, Hilger I. Proliferating and quiescent human umbilical vein endothelial cells (HUVECs): a potential in vitro model to evaluate contrast agents for molecular imaging of angiogenesis. Contrast Media Mol Imaging. 2009;4:192-8 pubmed publisher
    ..NIRF-imaging using the proposed model was feasible. We conclude that the presented cell model might be useful in future angiogenesis applications, like evaluating new fluorophores and other contrast media. ..
  22. Herpin A, Schindler D, Kraiss A, Hornung U, Winkler C, Schartl M. Inhibition of primordial germ cell proliferation by the medaka male determining gene Dmrt I bY. BMC Dev Biol. 2007;7:99 pubmed
    ..In medaka, dmrt I bY mediates a mitotic arrest of PGCs in males prior to testes differentiation at the sex determination stage. This occurs possibly via a cross-talk of Sertoli cells and PGCs. ..
  23. Hartleben B, Gödel M, Meyer Schwesinger C, Liu S, Ulrich T, Köbler S, et al. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest. 2010;120:1084-96 pubmed publisher
  24. Swiercz J, Kuner R, Behrens J, Offermanns S. Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron. 2002;35:51-63 pubmed
  25. Ritzi M, Tillack K, Gerhardt J, Ott E, Humme S, Kremmer E, et al. Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virus. J Cell Sci. 2003;116:3971-84 pubmed
    ..These findings indicate that HsOrc is a dynamic complex and that its DNA binding activity is regulated differently in the various stages of the cell cycle. ..
  26. Fürst R, Brueckl C, Kuebler W, Zahler S, Krotz F, Gorlach A, et al. Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2-activation. Circ Res. 2005;96:43-53 pubmed
    ..In summary, our work provides insights into the mechanisms by which ANP induces MKP-1 and shows that ANP is a novel endogenous activator of endothelial Rac1 and Nox/Nox2. ..
  27. Stirnweiss J, Valkova C, Ziesché E, Drube S, Liebmann C. Muscarinic M2 receptors mediate transactivation of EGF receptor through Fyn kinase and without matrix metalloproteases. Cell Signal. 2006;18:1338-49 pubmed
    ..This specific role of Fyn can be verified in SH-SY5Y human neuroblastoma cells with endogenously expressed M2 receptors. ..
  28. Jager M, Jelinek E, Wess K, Scharfstädt A, Jacobson M, Kevy S, et al. Bone marrow concentrate: a novel strategy for bone defect treatment. Curr Stem Cell Res Ther. 2009;4:34-43 pubmed
    ..Although strong efforts have been made over the last decade to introduce stem cell and tissue engineering treatment strategies to the field of orthopaedics, only few clinical applications are currently available...
  29. Schallenberg M, Charalambous P, Thanos S. GM-CSF regulates the ERK1/2 pathways and protects injured retinal ganglion cells from induced death. Exp Eye Res. 2009;89:665-77 pubmed publisher
    ..Like in vitro, GM-CSF counteracts the staurosporine-induced cell death in vivo and protects RGCs from axotomy-induced degeneration. Our data suggest that GM-CSF might be a novel therapeutic agent in neuropathic disease of the eye. ..
  30. Henes J, Schmit M, Morote Garcia J, Mirakaj V, Kohler D, Glover L, et al. Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury. FASEB J. 2009;23:4244-55 pubmed publisher
    ..Taken together these studies identify tissue-specific VASP as a central protein in the control of the alveolar-capillary barrier properties during ALI. ..
  31. Sparna T, Retey J, Schmich K, Albrecht U, Naumann K, Gretz N, et al. Genome-wide comparison between IL-17 and combined TNF-alpha/IL-17 induced genes in primary murine hepatocytes. BMC Genomics. 2010;11:226 pubmed publisher
    ..Gene expression profile suggests IL-17 alone and in concert with TNF-alpha a role in sustaining liver inflammatory processes. IL-17 might exceed this function by RNA stabilization. ..
  32. Ankerhold R, Leppert C, Bastmeyer M, Stuermer C. E587 antigen is upregulated by goldfish oligodendrocytes after optic nerve lesion and supports retinal axon regeneration. Glia. 1998;23:257-70 pubmed
  33. Drumm K, Bauer B, Freudinger R, Gekle M. Albumin induces NF-kappaB expression in human proximal tubule-derived cells (IHKE-1). Cell Physiol Biochem. 2002;12:187-96 pubmed
  34. Preuss U, Landsberg G, Scheidtmann K. Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase. Nucleic Acids Res. 2003;31:878-85 pubmed
    ..These findings strongly suggest that Dlk is a centromere-specific histone kinase that might play a role in labeling centromere-specific chromatin for subsequent mitotic processes. ..
  35. Bode H, Irschik H, Wenzel S, Reichenbach H, Muller R, Hofle G. The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum. J Nat Prod. 2003;66:1203-6 pubmed
    ..Leupyrrin A1 (1) shows good biological activity against various fungi and eukaryotic cells. ..
  36. Nazlican H, Zeschnigk M, Claussen U, Michel S, Boehringer S, Gillessen Kaesbach G, et al. Somatic mosaicism in patients with Angelman syndrome and an imprinting defect. Hum Mol Genet. 2004;13:2547-55 pubmed
    ..In conclusion, we suggest that the role of mosaic imprinting defects in mental retardation is underestimated. ..
  37. Lotz K, Pyrowolakis G, Jentsch S. BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival. Mol Cell Biol. 2004;24:9339-50 pubmed
    ..Thus, although BRUCE is broadly expressed in embryonic, extraembryonic, and adult mouse tissues, this bifunctional protein might play a unique role in normal trophoblast differentiation and embryonic survival. ..
  38. Rambold A, Miesbauer M, Rapaport D, Bartke T, Baier M, Winklhofer K, et al. Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP. Mol Biol Cell. 2006;17:3356-68 pubmed
    ..Our study reveals a compartment-specific toxicity of PrP misfolding that involves coaggregation of Bcl-2 and indicates a protective role of molecular chaperones. ..
  39. Hensellek S, Brell P, Schaible H, Bräuer R, Segond von Banchet G. The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation. Mol Cell Neurosci. 2007;36:381-91 pubmed
    ..Furthermore, we found that activation of ERK but not of p38 kinase or cyclooxygenases is critically involved in the TNFalpha-induced increase of TRPV1 receptor expression. ..
  40. Klimaschewski L. Regulation of galanin in rat sympathetic neurons in vitro. Neurosci Lett. 1997;234:87-90 pubmed
    ..The results corroborate the hypothesis that LIF, presumably released from ganglionic satellite cells, induces galanin in a subpopulation of sympathetic neurons in vivo and in vitro. ..
  41. Sindiće A, Başoglu C, Cerçi A, Hirsch J, Potthast R, Kuhn M, et al. Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells. J Biol Chem. 2002;277:17758-64 pubmed
    ..For uroguanylin two distinct signaling pathways exist in IHKE-1 cells, one involves GC-C and cGMP as second messenger, the other is cGMP-independent and connected to a pertussis toxin-sensitive G protein. ..
  42. Fleming I, Schulz C, Fichtlscherer B, Kemp B, Fisslthaler B, Busse R. AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets. Thromb Haemost. 2003;90:863-71 pubmed
  43. De Lima A, Lima B, Voigt T. Earliest spontaneous activity differentially regulates neocortical GABAergic interneuron subpopulations. Eur J Neurosci. 2007;25:1-16 pubmed
    ..Further, our results indicate that alterations of cell generation by activity manipulations might be overwritten by later activity effects on the survival of GABAergic cell populations. ..
  44. Frey U, Lieb W, Erdmann J, Savidou D, Heusch G, Leineweber K, et al. Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans. Eur Heart J. 2008;29:888-97 pubmed publisher
    ..52; P = 0.005). A novel polymorphism in the Gq promoter region is associated with enhanced promoter activity, Gq expression, intracellular signal transduction, and increased prevalence of LVH, particularly in women. ..
  45. Dje N Guessan P, Riediger F, Vardarova K, Scharf S, Eitel J, Opitz B, et al. Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. Arterioscler Thromb Vasc Biol. 2009;29:380-6 pubmed publisher
    ..In situ experiments indicated decreased expression of HDAC2 in endothelial cells in atherosclerotic plaques of human coronary arteries. Histone modifications seem to play an important role in atherosclerosis. ..
  46. Toutzaris D, Lewerenz J, Albrecht P, Jensen L, Letz J, Geerts A, et al. A novel giant peroxisomal superoxide dismutase motif-containing protein. Free Radic Biol Med. 2010;48:811-20 pubmed publisher
    ..Despite the presence of a SOD motif, which is necessary for protection in mammalian cells, the protein is not a functional SOD, but might be involved in SOD activity. ..
  47. Sharma C, Hoffmann S, Darfeuille F, Reignier J, Findeiss S, Sittka A, et al. The primary transcriptome of the major human pathogen Helicobacter pylori. Nature. 2010;464:250-5 pubmed publisher
    ..Our approach establishes a paradigm for mapping and annotating the primary transcriptomes of many living species. ..
  48. Kornau H, Schenker L, Kennedy M, Seeburg P. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 1995;269:1737-40 pubmed
    ..The interaction of these proteins may affect the plasticity of excitatory synapses. ..
  49. Wolfl M, Batten W, Posovszky C, Bernhard H, Berthold F. Gangliosides inhibit the development from monocytes to dendritic cells. Clin Exp Immunol. 2002;130:441-8 pubmed
    ..Suppression was induced by GM2, but not by the other gangliosides. These data suggest that certain gangliosides impair DC precursors, implying a possible mechanism for tumour escape. ..
  50. Bürkle L, Cedzich A, Döpke C, Stransky H, Okumoto S, Gillissen B, et al. Transport of cytokinins mediated by purine transporters of the PUP family expressed in phloem, hydathodes, and pollen of Arabidopsis. Plant J. 2003;34:13-26 pubmed
    ..In summary, three closely related PUPs are differentially expressed in Arabidopsis and at least two PUPs have properties similar to the adenine and cytokinin transport system identified in Arabidopsis cell cultures. ..
  51. Burga L, Wellmann F, Lukacin R, Witte S, Schwab W, Schröder J, et al. Unusual pseudosubstrate specificity of a novel 3,5-dimethoxyphenol O-methyltransferase cloned from Ruta graveolens L. Arch Biochem Biophys. 2005;440:54-64 pubmed
    ..0 microM. Thus, the OMT exhibited TMT activity with almost equivalent affinity to the thiol pseudosubstrate which is structurally unrelated to methoxyphenols...
  52. Briegert M, Enk A, Kaina B. Change in expression of MGMT during maturation of human monocytes into dendritic cells. DNA Repair (Amst). 2007;6:1255-63 pubmed
    ..The data provide an example that high MGMT expression level does not necessarily implicate a higher level of resistance against O6-alkylating agents. ..
  53. Chamulitrat W. Role of gp91phox homolog nox1 in induction of premalignant spindle phenotypes of HPV 16 E6/E7-immortalized human keratinocytes. ScientificWorldJournal. 2010;10:1435-49 pubmed publisher
    ..Understanding these mechanisms may provide insight into Nox1 and redox signaling components as potential therapeutic targets to inhibit tumor progression. ..
  54. Zhou J, Köhl R, Herr B, Frank R, Brüne B. Calpain mediates a von Hippel-Lindau protein-independent destruction of hypoxia-inducible factor-1alpha. Mol Biol Cell. 2006;17:1549-58 pubmed
    ..We conclude that calcium contributes to HIF-1alpha destruction involving the calpain system. ..
  55. Schneider T, Reiter C, Eule E, Bader B, Lichte B, Nie Z, et al. Restricted expression of the irreC-rst protein is required for normal axonal projections of columnar visual neurons. Neuron. 1995;15:259-71 pubmed
    ..Epigenesis of the phenotypes can be explained partially on the bases of homophilic irreC-rst interactions. ..
  56. Noga O, Englmann C, Hanf G, Grützkau A, Seybold J, Kunkel G. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Clin Exp Allergy. 2003;33:649-54 pubmed
    ..Eosinophils store, produce and release NGF, BDNF and NT-3. They are a possible source of elevated neurotrophin levels found in allergy and asthma. ..
  57. Honda R, Körner R, Nigg E. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell. 2003;14:3325-41 pubmed
    ..A nonphosphorylatable mutant (TSS893-895AAA) was a poor activator of Aurora B, demonstrating that INCENP phosphorylation is important for kinase activation. ..
  58. Henschler R, Piiper A, Bistrian R, Möbest D. SDF-1alpha-induced intracellular calcium transient involves Rho GTPase signalling and is required for migration of hematopoietic progenitor cells. Biochem Biophys Res Commun. 2003;311:1067-71 pubmed
    ..Our data indicate that the small GTPase Rho is required for the induction of Ca(2+) transients in HPC, which in turn are necessary for the coordinated migratory response of HPC both in vitro and in vivo. ..
  59. Kloss S, Srivastava R, Mülsch A. Down-regulation of soluble guanylyl cyclase expression by cyclic AMP is mediated by mRNA-stabilizing protein HuR. Mol Pharmacol. 2004;65:1440-51 pubmed
    ..We conclude that forskolin/cAMP decrease the expression of heterodimeric sGC in rat aortic smooth muscle cells via activation of Fos/AP-1, which decreases the expression of HuR and thus destabilizes the sGCalpha1 and beta1 mRNA. ..
  60. Lang D, Reuter S, Buzescu T, August C, Heidenreich S. Heme-induced heme oxygenase-1 (HO-1) in human monocytes inhibits apoptosis despite caspase-3 up-regulation. Int Immunol. 2005;17:155-65 pubmed
    ..The fact that HO-1 may adversely affect monocyte survival and differentiation could be of particular significance in future therapies for occlusive vascular diseases or transplant rejection. ..
  61. Walcher D, Hess K, Heinz P, Petscher K, Vasic D, Kintscher U, et al. Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma. Hypertension. 2008;51:259-66 pubmed
    ..These data provide a novel mechanism to explain how telmisartan modulates lymphocyte activation by its PPARgamma-activating properties. ..
  62. Muller P, Kazakov A, Jagoda P, Semenov A, Bohm M, Laufs U. ACE inhibition promotes upregulation of endothelial progenitor cells and neoangiogenesis in cardiac pressure overload. Cardiovasc Res. 2009;83:106-14 pubmed publisher
    ..The regulation of progenitor cells from the bone marrow identifies a novel effect of ACE inhibitors during cardiac remodelling. ..
  63. Friedrich M, Grahnert A, Klein C, Tschop K, Engeland K, Hauschildt S. Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene. Biochim Biophys Acta. 2006;1759:270-80 pubmed
    ..This specific use is evolutionary conserved as shown by analysis of the 5' UTR of the mouse ART3 mRNA. ..
  64. Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, et al. Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. Nat Med. 2008;14:1106-11 pubmed publisher
    ..The reduction of brain pE-Abeta by inhibition of glutaminyl cyclase offers a new therapeutic option for the treatment of Alzheimer's disease and provides implications for other amyloidoses, such as familial Danish dementia. ..
  65. Pérez Revuelta B, Fukumori A, Lammich S, Yamasaki A, Haass C, Steiner H. Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage. J Neurochem. 2010;112:940-50 pubmed publisher
    ..These findings broaden our understanding of gamma-secretase substrate recognition and cleavage, which may prove crucial for therapeutic targeting of the enzyme. ..
  66. Selbert S, Fischer P, Pongratz D, Stewart M, Noegel A. Expression and localization of annexin VII (synexin) in muscle cells. J Cell Sci. 1995;108 ( Pt 1):85-95 pubmed
    ..The results obtained indicate a developmentally and Ca(2+)-regulated localization and expression of annexin VII and raise the possibility that annexin VII may play a role in excitation-contraction coupling in skeletal muscle. ..
  67. Allam A, Illges H. Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells. Immunobiology. 2000;202:353-62 pubmed
    ..The effect was specific to CD8alpha in that CD4 expression was not affected and specific for calyculin A. Okadaic acid, another phosphatase inhibitor did not show any influence on the expression of CD4 or CD8. ..
  68. Herkert M, Shakhman O, Schweins E, Becker C. Beta-bungarotoxin is a potent inducer of apoptosis in cultured rat neurons by receptor-mediated internalization. Eur J Neurosci. 2001;14:821-8 pubmed
  69. Palmada M, Dieter M, Speil A, Bohmer C, Mack A, Wagner H, et al. Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1. Am J Physiol Gastrointest Liver Physiol. 2004;287:G143-50 pubmed
    ..Thus the present study reveals a novel signaling pathway in the regulation of intestinal phosphate transport, which may be important for regulation of phosphate balance. ..
  70. Eberlein König B, Rakoski J, Behrendt H, Ring J. Use of CD63 expression as marker of in vitro basophil activation in identifying the culprit in insect venom allergy. J Investig Allergol Clin Immunol. 2004;14:10-6 pubmed
  71. Allam R, Pawar R, Kulkarni O, Hornung V, Hartmann G, Segerer S, et al. Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses. Eur J Immunol. 2008;38:3487-98 pubmed publisher
    ..We conclude, 3P-RNA or non-CpG DNA both trigger autoimmune disease in MRL(lpr/lpr) mice by specifically activating adaptive immunity but similarly enhance inflammation on the tissue level. ..
  72. Daigle N, Beaudouin J, Hartnell L, Imreh G, Hallberg E, Lippincott Schwartz J, et al. Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells. J Cell Biol. 2001;154:71-84 pubmed
    ..Assembly and immobilization of both nucleoporins occurred before detectable recruitment of lamin B1, which is thus unlikely to mediate initiation of NPC assembly at the end of mitosis. ..
  73. Dedio J, Wiemer G, Rutten H, Dendorfer A, Schölkens B, Muller Esterl W, et al. Tissue kallikrein KLK1 is expressed de novo in endothelial cells and mediates relaxation of human umbilical veins. Biol Chem. 2001;382:1483-90 pubmed
    ..We conclude that endothelial cells de novo express significant amounts of tissue kallikrein, which likely serves in the local generation of vasoactive kinins. ..
  74. Xian Tao Li -, Dyachenko V, Zuzarte M, Putzke C, Preisig Müller R, Isenberg G, et al. The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle. Cardiovasc Res. 2006;69:86-97 pubmed
  75. Galler K, Schweikl H, Thonemann B, D Souza R, Schmalz G. Human pulp-derived cells immortalized with Simian Virus 40 T-antigen. Eur J Oral Sci. 2006;114:138-46 pubmed
    ..Transfection of human pulp-derived cells resulted in an immortalized cell line retaining many of the phenotypic characteristics observed in primary cells. ..
  76. Berghöfer B, Frommer T, Haley G, Fink L, Bein G, Hackstein H. TLR7 ligands induce higher IFN-alpha production in females. J Immunol. 2006;177:2088-96 pubmed
    ..These findings may explain the higher prevalence of SLE in females and the reported decreased therapeutic efficacy of synthetic TLR7 ligands in male individuals. ..
  77. Sawamiphak S, Seidel S, Essmann C, Wilkinson G, Pitulescu M, Acker T, et al. Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature. 2010;465:487-91 pubmed publisher
    ..Blocking ephrin-B2 reverse signalling may be an attractive alternative or combinatorial anti-angiogenic therapy strategy to disrupt VEGFR2 function in tumour angiogenesis...
  78. Gajera C, Emich H, Lioubinski O, Christ A, Beckervordersandforth Bonk R, Yoshikawa K, et al. LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. J Cell Sci. 2010;123:1922-30 pubmed publisher
    ..Our findings suggest a novel mechanism whereby LRP2-mediated catabolism of BMP4 in the ependyma modulates the microenvironment of the SEZ and enables adult neurogenesis to proceed...
  79. Tillet E, Mann K, Nischt R, Pan T, Chu M, Timpl R. Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain. Eur J Biochem. 1995;228:160-8 pubmed
    ..Whether this process also occurs in situ remains to be shown. ..
  80. Rabenau H, Ohlinger V, Anderson J, Selb B, Cinatl J, Wolf W, et al. Contamination of genetically engineered CHO-cells by epizootic haemorrhagic disease virus (EHDV). Biologicals. 1993;21:207-14 pubmed
    ..Potential sources of the contaminating virus and feasible procedures to avoid adventitous virus infections in cell cultures are discussed. ..
  81. Albert D, Zündorf I, Dingermann T, Muller W, Steinhilber D, Werz O. Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochem Pharmacol. 2002;64:1767-75 pubmed
  82. Kremerskothen J, Plaas C, Kindler S, Frotscher M, Barnekow A. Synaptopodin, a molecule involved in the formation of the dendritic spine apparatus, is a dual actin/alpha-actinin binding protein. J Neurochem. 2005;92:597-606 pubmed
  83. Dragusin M, Wehner S, Kelly S, Wang E, Merrill A, Kalff J, et al. Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. FASEB J. 2006;20:1930-2 pubmed
    ..Thus, the sustained elevated concentration of the two bioactive sphingolipids in this tissue could at least in part explain postoperative intestinal dysmotility. ..
  84. Kaltz N, Funari A, Hippauf S, Delorme B, Noel D, Riminucci M, et al. In vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes. Stem Cells. 2008;26:2419-24 pubmed publisher
    ..Despite low-level expression of POU5F1, we were unable to precipitate POU5F1 protein in either BM-MSC or UVSC. These results demonstrate that MSC stemness does not correlate to expression of POU5F1 transcripts or its pseudogenes. ..
  85. Samochocki M, Höffle A, Fehrenbacher A, Jostock R, Ludwig J, Christner C, et al. Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J Pharmacol Exp Ther. 2003;305:1024-36 pubmed
    ..Galantamine's APL action directly addresses the nicotinic deficit in AD. ..
  86. Popa M, Alekov A, Bail S, Lehmann Horn F, Lerche H. Cooperative effect of S4-S5 loops in domains D3 and D4 on fast inactivation of the Na+ channel. J Physiol. 2004;561:39-51 pubmed
    ..We conclude that fast inactivation of the Na(+) channel involves both S4-S5 loops in D3 and D4 in a cooperative manner. D3/S4-S5 also plays an important role in activation and deactivation. ..
  87. Giese B, Dittmann S, Paprotka K, Levin K, Weltrowski A, Biehler D, et al. Staphylococcal alpha-toxin is not sufficient to mediate escape from phagolysosomes in upper-airway epithelial cells. Infect Immun. 2009;77:3611-25 pubmed publisher
    ..Thus, our results suggest that staphylococcal alpha-toxin is not sufficient to mediate phagolysosomal escape in upper-airway epithelial cells. ..
  88. Fassler R, Rohwedel J, Maltsev V, Bloch W, Lentini S, Guan K, et al. Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin. J Cell Sci. 1996;109 ( Pt 13):2989-99 pubmed
    ..Thus, we conclude that interactions with the extracellular matrix via beta 1 integrin is necessary for differentiation and the maintenance of a specialized phenotype of cardiac muscle cells. ..
  89. Jensen B, Krämer B, Kurtz A. Adrenomedullin stimulates renin release and renin mRNA in mouse juxtaglomerular granular cells. Hypertension. 1997;29:1148-55 pubmed
    ..AM could act as an autocrine/paracrine stimulatory factor in the control of renin secretion and renin gene expression. ..
  90. Ostendorf T, van Roeyen C, Peterson J, Kunter U, Eitner F, Hamad A, et al. A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis. J Am Soc Nephrol. 2003;14:2237-47 pubmed
  91. Kahles T, Luedike P, Endres M, Galla H, Steinmetz H, Busse R, et al. NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke. Stroke. 2007;38:3000-6 pubmed
    ..Inhibition of NADPH oxidase is a promising approach to reduce brain injury after stroke. ..
  92. Hauber I, Hohenberg H, Holstermann B, Hunstein W, Hauber J. The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection. Proc Natl Acad Sci U S A. 2009;106:9033-8 pubmed publisher
    ..Therefore, EGCG appears to be a promising supplement to antiretroviral microbicides to reduce sexual transmission of HIV-1. ..