Experts and Doctors on corticotropin releasing hormone in Japan


Locale: Japan
Topic: corticotropin releasing hormone

Top Publications

  1. Sari D, Kuwahara S, Tsukamoto Y, Hori H, Kunugita N, Arashidani K, et al. Effect of prolonged exposure to low concentrations of formaldehyde on the corticotropin releasing hormone neurons in the hypothalamus and adrenocorticotropic hormone cells in the pituitary gland in female mice. Brain Res. 2004;1013:107-16 pubmed
    ..We conclude that our experimental system may be a suitable animal model for SBS and/or multiple chemical sensitivity (MCS). ..
  2. Yorimitsu M, Okada S, Yamaguchi Shima N, Shimizu T, Arai J, Yokotani K. Role of brain adrenoceptors in the corticortopin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats. Life Sci. 2008;82:487-94 pubmed publisher
    ..Furthermore, central alpha(2) adrenoceptors are involved in modulating the CRF-induced elevation of both plasma catecholamines. ..
  3. Sari D, Kuwahara S, Furuya M, Tsukamoto Y, Hori H, Kunugita N, et al. Hypothalamo-pituitary-adrenal gland axis in mice inhaling toluene prior to low-level long-term exposure to formaldehyde. J Vet Med Sci. 2005;67:303-9 pubmed
  4. Horiba N, Suda T, Aiba M, Naruse M, Nomura K, Imamura M, et al. Lysine vasopressin stimulation of cortisol secretion in patients with adrenocorticotropin-independent macronodular adrenal hyperplasia. J Clin Endocrinol Metab. 1995;80:2336-41 pubmed
    ..The cortisol response to LVP may serve to facilitate their diagnosis and choice of therapy. ..
  5. Gotoh K, Masaki T, Chiba S, Higuchi K, Kakuma T, Shimizu H, et al. Hypothalamic neuronal histamine signaling in the estrogen deficiency-induced obesity. J Neurochem. 2009;110:1796-805 pubmed publisher
    ..These results indicate that CRH and hypothalamic neuronal histamine mediate the suppressive effects of E2 on feeding behavior and body weight. ..
  6. Suda T, Tomori N, Sumitomo T, Nakagami Y, Tozawa F, Ushiyama T, et al. Radioimmunoassay of corticotropin-releasing hormone: methodology and clinical application. Horm Metab Res Suppl. 1987;16:47-51 pubmed
    ..In the absence of the long negative feedback control of ACTH secretion by glucocorticoids, ACTH originating from the pituitary may regulate ACTH secretion form the pituitary through inhibition of CRH release...
  7. Iwasaki Y, Nishiyama M, Taguchi T, Kambayashi M, Asai M, Yoshida M, et al. Activation of AMP-activated protein kinase stimulates proopiomelanocortin gene transcription in AtT20 corticotroph cells. Am J Physiol Endocrinol Metab. 2007;292:E1899-905 pubmed
    ..Our results suggest that intracellular energy depletion with the resultant activation of AMPK directly stimulates the HPA axis at the pituitary level by increasing the expression of POMC gene. ..
  8. Noguchi T, Makino S, Maruyama H, Hashimoto K. Regulation of proopiomelanocortin gene transcription during single and repeated immobilization stress. Neuroendocrinology. 2006;84:21-30 pubmed
  9. Chida D, Imaki T, Suda T, Iwakura Y. Involvement of corticotropin-releasing hormone- and interleukin (IL)-6-dependent proopiomelanocortin induction in the anterior pituitary during hypothalamic-pituitary-adrenal axis activation by IL-1alpha. Endocrinology. 2005;146:5496-502 pubmed
    ..Our results suggest a role for IL-1alpha/beta in the induction of POMC in the AP through the induction of two independent pathways, CRH and IL-6. ..

More Information


  1. Fujikawa T, Soya H, Tamashiro K, Sakai R, McEwen B, Nakai N, et al. Prolactin prevents acute stress-induced hypocalcemia and ulcerogenesis by acting in the brain of rat. Endocrinology. 2004;145:2006-13 pubmed
  2. Yamamori E, Iwasaki Y, Oki Y, Yoshida M, Asai M, Kambayashii M, et al. Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion. Endocrinology. 2004;145:36-8 pubmed
    ..These results suggest that ryanodine receptor-mediated calcium-induced calcium release is involved in the regulation of CRH-induced ACTH release. ..
  3. Pournajafi Nazarloo H, Tanaka Y, Dorobantu M, Hashimoto K. Modulation of corticotropin-releasing hormone receptor type 2 mRNA expression by CRH deficiency or stress in the mouse heart. Regul Pept. 2003;115:131-8 pubmed
  4. Pournajafi Nazarloo H, Takao T, Taguchi T, Ito H, Hashimoto K. Modulation of type I IL-1 receptor and IL-1 beta mRNA expression followed by endotoxin treatment in the corticotropin-releasing hormone-deficient mouse. J Neuroimmunol. 2003;140:102-8 pubmed
    ..Lack of CRH attenuated LPS administration induced increase of IL-1beta mRNA expression in the spleen. These data demonstrate the pivotal and organ-specific modulation of CRH for IL-1 and IL-1R1 mRNAs following endotoxin treatment. ..
  5. Yamazaki T, Waki H, Kohsaka A, Nakamura T, Cui H, Yukawa K, et al. Microinjection of urocortin into the rat nucleus tractus solitarii decreases arterial blood pressure. Auton Neurosci. 2008;142:51-4 pubmed publisher
    ..Our results suggest that Ucn I in the NTS may play an important role in cardiovascular regulation and the cardiovascular effects of Ucn I may be mediated by activation of both CRF-R1 and -R2, which are known to be present in the NTS. ..
  6. Ise S, Ohta H. Power spectrum analysis of ultrasonic vocalization elicited by maternal separation in rat pups. Brain Res. 2009;1283:58-64 pubmed publisher
    ..High-frequency components, but not low-frequency components, of the ultrasonic vocalization were sensitive to changes in negative affective state of isolated pups. ..
  7. Okumura T, Yamada H, Motomura W, Kohgo Y. Cocaine-amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotropin-releasing factor system. Endocrinology. 2000;141:2854-60 pubmed
    ..All these results suggest that CART acts in the brain to inhibit gastric function via brain CRF system. The vagal pathway and the prostaglandin system are not involved in the acid inhibition. ..
  8. Funasaka Y, Sato H, Chakraborty A, Ohashi A, Chrousos G, Ichihashi M. Expression of proopiomelanocortin, corticotropin-releasing hormone (CRH), and CRH receptor in melanoma cells, nevus cells, and normal human melanocytes. J Investig Dermatol Symp Proc. 1999;4:105-9 pubmed
    ..These results indicate that tumor progression accentuates CRH, CRH-R, and POMC expression by melanoma cells...
  9. Makino S, Asaba K, Nishiyama M, Hashimoto K. Decreased type 2 corticotropin-releasing hormone receptor mRNA expression in the ventromedial hypothalamus during repeated immobilization stress. Neuroendocrinology. 1999;70:160-7 pubmed
  10. Inui A. Feeding and body-weight regulation by hypothalamic neuropeptides--mediation of the actions of leptin. Trends Neurosci. 1999;22:62-7 pubmed
  11. Yamano M, Tohyama M. Distribution of corticotropin-releasing factor and calcitonin gene-related peptide in the developing mouse cerebellum. Neurosci Res. 1994;19:387-96 pubmed
    ..Furthermore, CRF-IR fibers gradually changed to become typical climbing fibers, while CGRP-IR disappeared altogether. ..
  12. Shibasaki T, Yamada K, Yamauchi N, Imaki T, Hotta M, Demura H. Beta 1-adrenergic mechanism is involved in stress-induced increase in arousal. Neurosci Lett. 1994;180:167-70 pubmed
    ..Atropine did not affect the PbNa-induced sleeping time in restrained rats. These results suggest that in addition to CRH, the brain beta 1-adrenergic system is involved in the restraint stress-induced increase in arousal...
  13. Thammacharoen S, Geary N, Lutz T, Ogawa S, Asarian L. Divergent effects of estradiol and the estrogen receptor-alpha agonist PPT on eating and activation of PVN CRH neurons in ovariectomized rats and mice. Brain Res. 2009;1268:88-96 pubmed publisher
    ..Finally, the rapid induction of c-Fos in CRH-expressing cells in the PVN by PPT suggests that PPT elicits a neural response that is similar to that elicited by stress or aversive emotional stimuli. ..
  14. Sakumoto R, Ito S, Komatsu T. Possible actions of corticotropin-releasing hormone in regulating porcine corpus luteum function. J Vet Med Sci. 2010;72:1173-7 pubmed
  15. Ataka K, Ito M, Shibata T. New views on antidiarrheal effect of wood creosote: is wood creosote really a gastrointestinal antiseptic?. Yakugaku Zasshi. 2005;125:937-50 pubmed
  16. Konishi S, Kasagi Y, Katsumata H, Minami S, Imaki T. Regulation of corticotropin-releasing factor (CRF) type-1 receptor gene expression by CRF in the hypothalamus. Endocr J. 2003;50:21-36 pubmed
    ..These results demonstrate that CRF directly affects hypothalamic neurons to increase CRFR-1 mRNA expression, providing evidence of a direct role for CRF in the regulation of CRFR-1 expression of hypothalamic neurons. ..
  17. Kasagi Y, Horiba N, Sakai K, Fukuda Y, Suda T. Involvement of cAMP-response element binding protein in corticotropin-releasing factor (CRF)-induced down-regulation of CRF receptor 1 gene expression in rat anterior pituitary cells. J Neuroendocrinol. 2002;14:587-92 pubmed
    ..These findings indicate that CRF may down-regulate CRF-R1 mRNA expression via a cAMP-PKA-mediated mechanism in rat anterior pituitary cells, and that CREB may mediate at least a portion of this inhibitory effect. ..
  18. Sato H, Nagashima Y, Chrousos G, Ichihashi M, Funasak Y. The expression of corticotropin-releasing hormone in melanoma. Pigment Cell Res. 2002;15:98-103 pubmed
    ..CRH induced POMC mRNA expression, an effect that was inhibited by a CRH antagonist. These results provide evidence for the existence of the CRH/POMC axis in pigmented lesions. ..
  19. Watanabe F, Oki Y, Ozawa M, Masuzawa M, Iwabuchi M, Yoshimi T, et al. Urocortin in human placenta and maternal plasma. Peptides. 1999;20:205-9 pubmed
    ..These data suggest that Ucn is produced and processed into the same form of synthetic Ucn in placenta, but not secreted into maternal blood. ..
  20. Kawahito Y, Sano H, Mukai S, Asai K, Kimura S, Yamamura Y, et al. Corticotropin releasing hormone in colonic mucosa in patients with ulcerative colitis. Gut. 1995;37:544-51 pubmed
    ..These results suggest that CRH may play a part in the modulation of intestinal immune and inflammatory system, and as a modulator in the pathogenesis of ulcerative colitis. ..