Experts and Doctors on colonic neoplasms in Japan


Locale: Japan
Topic: colonic neoplasms

Top Publications

  1. Takahashi S, Kasai K, Hatsuzawa K, Kitamura N, Misumi Y, Ikehara Y, et al. A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells. Biochem Biophys Res Commun. 1993;195:1019-26 pubmed
    ..Based on these data, we conclude that furin is the endoprotease that is involved in the precursor cleavage at RXK/RR sites within the constitutive secretory pathway. ..
  2. Miyaki M, Nishio J, Konishi M, Kikuchi Yanoshita R, Tanaka K, Muraoka M, et al. Drastic genetic instability of tumors and normal tissues in Turcot syndrome. Oncogene. 1997;15:2877-81 pubmed
    ..Additional unknown germline mutation may contribute to the genetic instability in normal tissues. ..
  3. Takesue F, Korenaga D, Yao T, Kabashima A, Sugimachi K. Development of colonic neoplasms and expressions of p53 and p21 proteins in experimental colitis of mice induced by dextran sulfate sodium. J Exp Clin Cancer Res. 2001;20:413-8 pubmed
    ..This experimental colitis model suggests that p53 and p21 protein expressions may contribute to carcinogenesis in DSS-induced colitis in mice and appears suitable to study cancer development in UC. ..
  4. Guleng B, Tateishi K, Ohta M, Kanai F, Jazag A, Ijichi H, et al. Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res. 2005;65:5864-71 pubmed
  5. Suzuki R, Kohno H, Yasui Y, Hata K, Sugie S, Miyamoto S, et al. Diet supplemented with citrus unshiu segment membrane suppresses chemically induced colonic preneoplastic lesions and fatty liver in male db/db mice. Int J Cancer. 2007;120:252-8 pubmed
  6. Sasaki K, Tsuno N, Sunami E, Kawai K, Hongo K, Hiyoshi M, et al. Resistance of colon cancer to 5-fluorouracil may be overcome by combination with chloroquine, an in vivo study. Anticancer Drugs. 2012;23:675-82 pubmed publisher
    ..Our findings suggest that the combination therapy of CQ and 5-FU should be considered as an effective strategy for the treatment of colorectal cancer. ..
  7. Kohno H, Suzuki R, Yasui Y, Hosokawa M, Miyashita K, Tanaka T. Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci. 2004;95:481-6 pubmed
  8. Nozoe T, Rikimaru T, Mori E, Okuyama T, Takahashi I. Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma. J Surg Oncol. 2006;94:132-7 pubmed
    ..Combined data of preoperative increase in CEA and CA19-9 in sera can provide a powerful and useful information to predict prognosis of patients with colorectal carcinoma. ..
  9. Kim M, Miyamoto S, Yasui Y, Oyama T, Murakami A, Tanaka T. Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice. Int J Cancer. 2009;124:264-71 pubmed publisher

More Information

Publications123 found, 100 shown here

  1. Kato Y, Takeda H, Dembo T, Fukuoka T, Tanahashi N. Progressive multiple cranial nerve palsies as the presenting symptom of meningeal carcinomatosis from occult colon adenocarcinoma. Intern Med. 2012;51:795-7 pubmed
    ..This should apply even when there is no known primary malignancy. ..
  2. Tateishi K, Ohta M, Kanai F, Guleng B, Tanaka Y, Asaoka Y, et al. Dysregulated expression of stem cell factor Bmi1 in precancerous lesions of the gastrointestinal tract. Clin Cancer Res. 2006;12:6960-6 pubmed
    ..The abnormal Bmi1 expression might link to malignant transformation via the disturbance of orderly histone modification. ..
  3. Nagata Y, Hiraoka M, Akuta K, Abe M, Takahashi M, Jo S, et al. Radiofrequency thermotherapy for malignant liver tumors. Cancer. 1990;65:1730-6 pubmed
    ..No apparent relationship was observed between the intratumor temperatures and local response rate. ..
  4. Mikami T, Yoshida T, Numata Y, Kikuchi M, Araki K, Nakada N, et al. Invasive behavior of ulcerative colitis-associated carcinoma is related to reduced expression of CD44 extracellular domain: comparison with sporadic colon carcinoma. Diagn Pathol. 2011;6:30 pubmed publisher
    ..The invasive behavior of UC-associated carcinoma is more associated with CD44 cleavage than with basement membrane disruption or sialyl-Lewis-antigen alteration. ..
  5. Yasui Y, Hosokawa M, Sahara T, Suzuki R, Ohgiya S, Kohno H, et al. Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells. Prostaglandins Leukot Essent Fatty Acids. 2005;73:113-9 pubmed
    ..These results suggest that BGO-FFA rich in 9c,11t,13t-CLN may induce apoptosis in Caco-2 cells through up-regulation of GADD45, p53 and PPARgamma. ..
  6. Komizu Y, Ueoka H, Goto K, Ueoka R. Remarkable inhibitory effects of hybrid liposomes on growth of human colon cancer cells through induction of cell cycle arrest along with apoptosis. Int J Nanomedicine. 2011;6:1913-20 pubmed publisher
    ..It was found for the first time that HL-n can induce both cell cycle arrest and apoptosis in colon cancer cells. The findings in this study should contribute to novel chemotherapy for colon cancer. ..
  7. Ueno T, Endo S, Saito R, Hirose M, Hirai S, Suzuki H, et al. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells. Oncol Res. 2013;21:155-64 pubmed publisher
    ..These results may help develop a novel treatment option for colorectal cancer using a SIRT inhibitor. ..
  8. Saito R, Takahashi T, Endo H, Kimura N, Kaneko U. [A case of subarachnoid hemorrhage complicated by acquired hemophilia]. No Shinkei Geka. 2009;37:1215-9 pubmed
    ..The aneurysm was successfully treated with endovascular parent artery occlusion. However, after a placing ventriculo-peritoneal shunt a month later, he developed severe coagulopathy due to acquired factor VIII inhibitor. ..
  9. Tanaka T, Shimizu M, Kohno H, Yoshitani S, Tsukio Y, Murakami A, et al. Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet. Life Sci. 2001;69:1935-45 pubmed
  10. Korekane H, Matsumoto A, Ota F, Hasegawa T, Misonou Y, Shida K, et al. Involvement of ST6Gal I in the biosynthesis of a unique human colon cancer biomarker candidate, alpha2,6-sialylated blood group type 2H (ST2H) antigen. J Biochem. 2010;148:359-70 pubmed publisher
    ..Many lines of evidence suggest the up-regulation of ST6Gal I in human colon cancer specimens. Collectively, these findings indicate that ST6Gal I is responsible for ST2H antigen biosynthesis in human colon cancer cells. ..
  11. Nakamura Y, Hattori N, Iida N, Yamashita S, Mori A, Kimura K, et al. Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway. Cancer Lett. 2017;402:100-109 pubmed publisher
    ..Thus, this study indicates the therapeutic potential of targeting of super-enhancers and mutant BRAF in patients with BRAFV600E-mutant colorectal cancer. ..
  12. Yoshitani S, Tanaka T, Kohno H, Takashima S. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by dietary capsaicin and rotenone. Int J Oncol. 2001;19:929-39 pubmed
    ..19%, 68% reduction, P=0.0226). Our results suggest that two natural compounds, capsaicin and rotenone, might be useful for the prevention of human colon cancers. ..
  13. Kokuryo D, Aoki I, Yuba E, Kono K, Aoshima S, Kershaw J, et al. Evaluation of a combination tumor treatment using thermo-triggered liposomal drug delivery and carbon ion irradiation. Transl Res. 2017;185:24-33 pubmed publisher
    ..The proposed strategy of combining high-LET irradiation and the nanodevice provides an effective approach for minimally invasive cancer treatment. ..
  14. Taketo M. COX-2 and colon cancer. Inflamm Res. 1998;47 Suppl 2:S112-6 pubmed
    ..The results provide direct genetic evidence that COX-2 plays a key role in tumorigenesis, and indicate that COX-2-selective inhibitors can be a new class of therapeutic agents for colorectal polyposis and cancer. ..
  15. Tanaka T, Kohno H, Murakami M, Shimada R, Kagami S, Sumida T, et al. Suppression of azoxymethane-induced colon carcinogenesis in male F344 rats by mandarin juices rich in beta-cryptoxanthin and hesperidin. Int J Cancer. 2000;88:146-50 pubmed
    ..In addition, treatment with MJ, MJ2, or MJ5 significantly increased apoptotic index in colonic adenocarcinoma. These findings might suggest effective chemopreventive ability of MJs, especially MJ5, in colon tumorigenesis. ..
  16. Fujisawa T, Sugiyama M, Tomimoto A, Wada K, Endo H, Takahashi H, et al. Inhibition of peroxisome proliferator-activated receptor gamma promotes tumorigenesis through activation of the beta-catenin / T cell factor (TCF) pathway in the mouse intestine. J Pharmacol Sci. 2008;108:535-44 pubmed
    ..beta-Catenin contributes to the promotion of tumorigenesis by PPARgamma antagonist due to activation of TCF/LEF (lymphoid enhancer factor) transcriptional factor. ..
  17. Nakachi T, Tabuchi T, Takasaki A, Arai S, Miyazawa K, Tomoda A. Anticancer activity of phenoxazines produced by bovine erythrocytes on colon cancer cells. Oncol Rep. 2010;23:1517-22 pubmed
    ..The present results demonstrate that Phx-1 and Phx-3, which were prepared by extensively improved methods using bovine erythrocytes, may be useful as therapeutic drugs against colon cancer that is intractable to chemotherapy. ..
  18. Ryoichi S, Hiroyuki M, Nobuyuki N, Tomohiro U, Jang K. Colonic adenocarcinoma in an Indiana pouch successfully treated by endoscopic mucosal resection. Int J Urol. 2007;14:661-2 pubmed
    ..The colonic adenocarcinoma was treated endoscopically and we were able to preserve the Indiana pouch. To our knowledge, this is the sixth case of colonic adenocarcinoma in an Indiana pouch...
  19. Tomita R, Igarashi S, Fujisaki S, Tanjoh K. The effects of neurotensin in the colon of patients with slow transit constipation. Hepatogastroenterology. 2007;54:1662-6 pubmed
    ..A decrease of NT mediates NANC excitatory nerves and plays an important role in the dysmotility observed in the colons of patients with STC. ..
  20. Yaguchi T, Saito M, Yasuda Y, Kanno T, Nakano T, Nishizaki T. Higher concentrations of extracellular ATP suppress proliferation of Caco-2 human colonic cancer cells via an unknown receptor involving PKC inhibition. Cell Physiol Biochem. 2010;26:125-34 pubmed publisher
    ..Extracellular ATP, at higher concentrations, suppresses Caco-2 cell proliferation at the S phase of cell cycling by inhibiting PKC, possibly as mediated via an unknown ATP receptor, followed by MAP kinase. ..
  21. Furuishi K, Matsuoka H, Takama M, Takahashi I, Misumi S, Shoji S. Blockage of N-myristoylation of HIV-1 gag induces the production of impotent progeny virus. Biochem Biophys Res Commun. 1997;237:504-11 pubmed
    ..Taken together, the results suggest that the myristoylation of HIV-1 gag seems to be responsible for both maturation of gag and acquisition of HIV-1 infectivity. ..
  22. Oba S, Ishii S. Semi-supervised discovery of differential genes. BMC Bioinformatics. 2006;7:414 pubmed
    ..The experimental results indicate that the ODP framework is effective for hypotheses including latent variables and is further improved by sharing the estimations of hidden variables over multiple tests. ..
  23. Kohno H, Suzuki R, Yasui Y, Miyamoto S, Wakabayashi K, Tanaka T. Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice. Clin Cancer Res. 2007;13:2519-25 pubmed
    ..Our findings suggest that UDCA rather than sulfasalazine could serve as an effective suppressing agent in colitis-related colon cancer development in mice. ..
  24. Mukaisho K, Suo M, Shimakage M, Kushima R, Inoue H, Hattori T. Down-regulation of drs mRNA in colorectal neoplasms. Jpn J Cancer Res. 2002;93:888-93 pubmed
  25. Konishi T, Watanabe T, Takei Y, Kojima T, Nagawa H. Confined progression of cap polyposis along the anastomotic line, implicating the role of inflammatory responses in the pathogenesis. Gastrointest Endosc. 2005;62:446-7; discussion 447 pubmed
  26. Tsunezumi J, Yamamoto K, Higashi S, Miyazaki K. Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces. FEBS J. 2008;275:4810-23 pubmed publisher
    ..It is supposed that the cleavage of cell surface annexin II by matrilysin contributes to tumor invasion and metastasis by enhancing tPA-mediated pericellular proteolysis by cancer cells. ..
  27. Yasutomi J, Koda K, Saito N, Nakajima N, Nasoff M, McKnight M, et al. Identification of the immunoreactive peptide sequence for AgSK1, an adenocarcinoma-restricted antigen. Tissue Antigens. 2000;55:157-61 pubmed
    ..This clone consisted of an amino terminal open reading frame of 54 amino acids and the carboxyl terminal 20 amino acids of this protein coding region contained the antigenic epitope recognized by HuMab SK1. ..
  28. Tanaka T, Maeda M, Kohno H, Murakami M, Kagami S, Miyake M, et al. Inhibition of azoxymethane-induced colon carcinogenesis in male F344 rats by the citrus limonoids obacunone and limonin. Carcinogenesis. 2001;22:193-8 pubmed
    ..0002). Our results suggest that the citrus limonoids obacunone and limonin might be useful for the prevention of human colon cancers. ..
  29. Kohno H, Suzuki R, Noguchi R, Hosokawa M, Miyashita K, Tanaka T. Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats. Jpn J Cancer Res. 2002;93:133-42 pubmed
    ..These findings might suggest possible chemopreventive activity of CLN in the early phase of colon tumorigenesis through modulation of cryptal cell proliferation activity and/or apoptosis. ..
  30. Tanakaya K, Yamaguchi T, Ishikawa H, Hinoi T, Furukawa Y, Hirata K, et al. Causes of Cancer Death Among First-Degree Relatives in Japanese Families with Lynch Syndrome. Anticancer Res. 2016;36:1985-9 pubmed
    ..Extra-colonic cancer in families with MSH2 mutation might require for more intensive surveillance. ..
  31. Nobuoka A, Takayama T, Miyanishi K, Sato T, Takanashi K, Hayashi T, et al. Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid. Gastroenterology. 2004;127:428-43 pubmed
    ..Glutathione-S-transferase P1-1 protects aberrant crypt foci from deoxycholic acid-induced apoptosis and may play a pivotal role in early colon carcinogenesis. ..
  32. Fujiwara Y, Yamazaki O, Takatsuka S, Kaizaki R, Inoue T. Granulocyte colony-stimulating factor-producing ascending colon cancer as indicated by histopathological findings: report of a case. Osaka City Med J. 2011;57:79-84 pubmed
    ..The prognosis of G-CSF-producing tumors is considered to be poor. Early diagnosis and surgical treatment are needed for patients with G-CSF-producing tumors, and continuous careful follow-up is required. ..
  33. Arakawa Y, Ozaki K, Okawa Y, Yamada H. Three missense mutations of DNA topoisomerase I in highly camptothecin-resistant colon cancer cell sublines. Oncol Rep. 2013;30:1053-8 pubmed publisher
    ..The Gln421 mutation was equivalent to a mutation recently found in camptothecin biosynthesizing plants, but it has not previously been found in mammalian cells...
  34. Inadera H, Nagai S, Dong H, Matsushima K. Molecular analysis of lipid-depleting factor in a colon-26-inoculated cancer cachexia model. Int J Cancer. 2002;101:37-45 pubmed
    ..These results suggest that the lipid-depleting factor in clone 20 plasma is different from either IL-6 or TNF-alpha, and that this factor interfered with not only lipolysis but also lipogenesis through SREBP-1 of 3T3-L1 adipocytes. ..
  35. Sasahira T, Sasaki T, Kuniyasu H. Interleukin-15 and transforming growth factor alpha are associated with depletion of tumor-associated macrophages in colon cancer. J Exp Clin Cancer Res. 2005;24:69-74 pubmed
    ..These results suggested that IL-15/TGF-alpha promotes depletion of TAMs and secretion of amphoterin in colon cancer. ..
  36. Uemura T, Shiozaki K, Yamaguchi K, Miyazaki S, Satomi S, Kato K, et al. Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin beta4. Oncogene. 2009;28:1218-29 pubmed publisher
    ..These results suggest that NEU1 is important in regulation of integrin beta4-mediated signaling, leading to suppression of metastasis. ..
  37. Furuhata T, Tokino T, Urano T, Nakamura Y. Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity. Oncogene. 1996;13:1965-70 pubmed
  38. Tanaka T, Yasui Y, Ishigamori Suzuki R, Oyama T. Citrus compounds inhibit inflammation- and obesity-related colon carcinogenesis in mice. Nutr Cancer. 2008;60 Suppl 1:70-80 pubmed publisher
    ..1% CUSM, and 59% inhibition by 0.5% CUSM. CUSM treatment also decreased serum level of triglycerides. Our findings suggest that certain citrus materials are capable of inhibiting clitis- and obesity-related colon carcinogenesis. ..
  39. Kimura Y, Shiozaki H, Hirao M, Maeno Y, Doki Y, Inoue M, et al. Expression of occludin, tight-junction-associated protein, in human digestive tract. Am J Pathol. 1997;151:45-54 pubmed
    ..In addition, occludin expression can serve as a histopathological indicator for differentiation in gastrointestinal adenocarcinomas. ..
  40. Kohno H, Suzuki R, Sugie S, Tanaka T. Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. BMC Cancer. 2005;5:46 pubmed
    ..The results suggest that COX-2 inhibitor and PPAR ligands could serve as an effective agent against colitis-related colon cancer development. ..
  41. Hirayama A, Kami K, Sugimoto M, Sugawara M, Toki N, Onozuka H, et al. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res. 2009;69:4918-25 pubmed publisher
  42. Ota T, Maeda M, Suto S, Tatsuka M. LyGDI functions in cancer metastasis by anchoring Rho proteins to the cell membrane. Mol Carcinog. 2004;39:206-20 pubmed
    ..These results suggest that LyGDI functions in the cell membrane to afford spatial regulation of Rho family GTPase signaling through ezrin radixin moesin (ERM) proteins during metastasis. ..
  43. Suzuki R, Kohno H, Sugie S, Tanaka T. Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane. Histol Histopathol. 2005;20:483-92 pubmed publisher
    ..Thus, our findings indicate that a tumor-promoting effect of DSS was dose-dependent (1% or more) and the effect might occur under the condition of inflammation and nitrosation stress. ..
  44. Ishikawa H, Saeki T, Otani T, Suzuki T, Shimozuma K, Nishino H, et al. Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. J Nutr. 2006;136:816S-820S pubmed publisher
    ..No adverse effect was observed in either group. The study showed that administering AGE to patients with advanced cancer of the digestive system improved NK cell activity, but caused no improvement in QOL. ..
  45. Kato T, Terashima T, Tomida S, Yamaguchi T, Kawamura H, Kimura N, et al. Cytokeratin 20-positive large cell neuroendocrine carcinoma of the colon. Pathol Int. 2005;55:524-9 pubmed
  46. Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin M, Taketo M. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell. 1998;92:645-56 pubmed
    ..These results indicate that mutations in DPC4 (SMAD4) play a significant role in the malignant progression of colorectal tumors. ..
  47. Nakagawa H, Murata Y, Koyama K, Fujiyama A, Miyoshi Y, Monden M, et al. Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin. Cancer Res. 1998;58:5176-81 pubmed
    ..These results suggest that the APCL protein may be involved in the Wnt/Wingless signal pathway, and the identification of a novel relative of APC may provide new insights into the function of APC. ..
  48. Sato Y, Onuma H, Okubo S, Fujikawa K, Shintani N, Takahashi Y. [A case of colon cancer resembling submucosal tumor with ossification]. Nihon Shokakibyo Gakkai Zasshi. 2007;104:678-83 pubmed
    ..Right hemicolectomy was performed. Pathological findings of the resected specimen showed mucinous adenocarcinoma invading the subserosa with heterotopic ossification of the same site as the calcification on CT...
  49. Shimizu M, Shirakami Y, Iwasa J, Shiraki M, Yasuda Y, Hata K, et al. Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. Clin Cancer Res. 2009;15:3068-75 pubmed publisher
    ..The present study examined the effects of BCAA on the development of azoxymethane (AOM)-initiated colonic premalignant lesions in C57BL/KsJ-db/db (db/db) mice that were obese and had hyperinsulinemia...
  50. Tanaka M, Adzuma K, Iwami M, Yoshimoto K, Monden Y, Itakura M. Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis. Cancer Lett. 1995;89:195-200 pubmed
    ..The full sequence of human calgizzarin was determined and its expression was remarkably elevated in colorectal cancers compared with that in normal colorectal mucosa. ..
  51. Iizaka M, Furukawa Y, Tsunoda T, Akashi H, Ogawa M, Nakamura Y. Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002;292:498-512 pubmed
    ..These data may lead to a better understanding of growth-suppressive effects on colonic epithelium, and may provide clues for identifying novel therapeutic and/or preventive molecular targets of colon cancer. ..
  52. Tanaka T, Yasui Y, Tanaka M, Tanaka T, Oyama T, Rahman K. Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. Chem Biol Interact. 2009;177:128-36 pubmed publisher
    ..These results may indicate the beneficial effects of MEL on colitis-related colon carcinogenesis and a potential application for inhibiting colorectal cancer development in the inflamed colon. ..
  53. Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, et al. Cloning of P2XM, a novel human P2X receptor gene regulated by p53. Cancer Res. 1997;57:3281-7 pubmed
    ..The results suggest that P2XM may play a significant role in the proliferation and/or differentiation of skeletal muscle cells and that its altered expression may be involved in the development of some sarcomas. ..
  54. Kishimoto T, Kokura K, Ohkawa N, Makino Y, Yoshida M, Hirohashi S, et al. Enhanced expression of a new class of liver-enriched b-Zip transcription factors, hepatocarcinogenesis-related transcription factor, in hepatocellular carcinomas of rats and humans. Cell Growth Differ. 1998;9:337-44 pubmed
    ..Injection of anti-HTF antibody decreased the growth rate of cultured HCC cells. Consequently, HTF is thought to participate in hepatocyte growth as well as in hepatocarcinogenesis. ..
  55. Nakajima S, Moriyama T, Hayashi H, Sakata I, Nakae Y, Takemura T. Hemopexin as a carrier protein of tumor-localizing Ga-metalloporphyrin-ATN-2. Cancer Lett. 2000;149:221-6 pubmed
    ..Glycoprotein with the same domain structure of hemopexin has been proposed to be an important carrier protein that forms the tumor-localizing activity of water-soluble porphyrin. ..
  56. Kawasoe T, Furukawa Y, Daigo Y, Nishiwaki T, Ishiguro H, Fujita M, et al. Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin. Cancer Res. 2000;60:3354-8 pubmed
    ..Our results implied that DRCTNNB1A is one of the genes involved in the beta-catenin-Tcf/Lef signaling pathway, and that reduced expression of DRCTNNB1A may have some role in colorectal carcinogenesis. ..
  57. Kohno H, Yasui Y, Suzuki R, Hosokawa M, Miyashita K, Tanaka T. Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid composition. Int J Cancer. 2004;110:896-901 pubmed
  58. Ohkawara S, Furuya H, Nagashima K, Asanuma N, Hino T. Oral administration of butyrivibrio fibrisolvens, a butyrate-producing bacterium, decreases the formation of aberrant crypt foci in the colon and rectum of mice. J Nutr. 2005;135:2878-83 pubmed
    ..These results suggest that colorectal cancer may be prevented or suppressed by the utilization of MDT-1 as a probiotic. Administration of MDT-1 had no harmful effect on the health of mice at least for 3 mo...
  59. Yanaka N, Ohata T, Toya K, Kanda M, Hirata A, Kato N. Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-?-stimulated HT-29 cells. Mol Nutr Food Res. 2011;55:635-43 pubmed publisher
    ..Vitamin B6 suppressed SPI-3 expression in the colon of rats and in TNF-?-stimulated HT-29 cells. Further, this study showed a possible role of vitamin B6 in the regulation of protein ubiquitination. ..
  60. Isozaki Y, Yamanishi M, Utsunomiya S, Yamaguchi S, Okita M, Matsumoto N, et al. [A case of disseminated carcinomatosis of bone marrow with disseminated intravascular coagulation caused by advanced colon cancer treated by mFOLFOX6]. Gan To Kagaku Ryoho. 2011;38:1705-8 pubmed
    ..He was treated with the systemic chemotherapy of modified FOLFOX6 (mFOLFOX6). After one course of the treatment, DIC was resolved and severe back pain and lumbargo were improved. ..
  61. Liu X, Takano C, Shimizu T, Yokobe S, Abe Kanoh N, Zhu B, et al. Inhibition of phosphatidylinositide 3-kinase ameliorates antiproliferation by benzyl isothiocyanate in human colon cancer cells. Biochem Biophys Res Commun. 2017;491:209-216 pubmed publisher
    ..Taken together, these results suggested that the PI3K/Akt/FoxO pathway negatively regulates the BITC-induced antiproliferation in human colorectal cancer cells. ..
  62. Hirose M, Masuda A, Ito N, Kamano K, Okuyama H. Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats. Carcinogenesis. 1990;11:731-5 pubmed
    ..8%). The results thus indicate that the alpha-linolenic acid (n-3)-rich perilla oil diet inhibits development of mammary gland, colon and kidney tumors as compared to linoleic acid (n-6)-rich safflower or soybean oil diet...
  63. Hirano F, Tanada H, Makino Y, Okamoto K, Hiramoto M, Handa H, et al. Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids. Carcinogenesis. 1996;17:427-33 pubmed
    ..Thus, we may indicate that bile acids exclusively induce nuclear AP-1 activity in colon adenocarcinoma cells. ..
  64. Kanamoto R, Azuma N, Suda H, Saeki T, Tsuchihashi Y, Iwami K, et al. Elimination of Na+-dependent bile acid transporter from small intestine by ileum resection increases [correction of increase] colonic tumorigenesis in the rat fed deoxycholic acid. Cancer Lett. 1999;145:115-20 pubmed
    ..These observations demonstrate that malabsorption of bile acids owing to the lack of ISBT enhanced colon tumorigenesis. ..
  65. Tashima S, Shimada S, Yamaguchi K, Tsuruta J, Ogawa M. Expression of brain-type glycogen phosphorylase is a potentially novel early biomarker in the carcinogenesis of human colorectal carcinomas. Am J Gastroenterol. 2000;95:255-63 pubmed
    ..It is suggested that BGP is a novel biomarker for carcinogenesis in both the pathways of ACS and the de novo colorectal carcinoma. ..
  66. Tanaka T, Kohno H, Tsukio Y, Honjo S, Tanino M, Miyake M, et al. Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats. Biofactors. 2000;13:213-8 pubmed
    ..Thus, citrus bitter limonoids obacunone and limonin possess chemopreventive effects on chemically induced rat colon carcinogenesis. ..
  67. Zhaorigetu S, Sasaki M, Watanabe H, Kato N. Supplemental silk protein, sericin, suppresses colon tumorigenesis in 1,2-dimethylhydrazine-treated mice by reducing oxidative stress and cell proliferation. Biosci Biotechnol Biochem. 2001;65:2181-6 pubmed
    ..The results suggest that dietary sericin suppresses the development of colon tumors by reducing oxidative stress, cell proliferation, and nitric oxide production. ..
  68. Kobayashi M, Iwamatsu A, Shinohara Kanda A, Ihara S, Fukui Y. Activation of ErbB3-PI3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas. Oncogene. 2003;22:1294-301 pubmed
    ..Taken together, activation of ErbB3 pathway may contribute to the development of dedifferentiated carcinomas. ..
  69. Takeuchi Y, Yoshikawa M, Tsukamoto N, Shiroi A, Hoshida Y, Enomoto Y, et al. Cronkhite-Canada syndrome with colon cancer, portal thrombosis, high titer of antinuclear antibodies, and membranous glomerulonephritis. J Gastroenterol. 2003;38:791-5 pubmed
    ..Although the pathogenesis of CCS is essentially unknown, these complications might have been indicative of an underlying immunological abnormality...
  70. Okazaki H, Mizuno M, Nasu J, Makidono C, Hiraoka S, Yamamoto K, et al. Difference in Ulex europaeus agglutinin I-binding activity of decay-accelerating factor detected in the stools of patients with colorectal cancer and ulcerative colitis. J Lab Clin Med. 2004;143:169-74 pubmed
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    ..However, the transfectants were not resistant to mitoxantrone or topotecan, the drugs previously thought to be the substrates of BCRP. Thus, our study presents a novel mechanism of drug resistance mediated by BCRP...
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