Experts and Doctors on coatomer protein in Germany


Locale: Germany
Topic: coatomer protein

Top Publications

  1. Rebl A, Anders E, Wimmers K, Goldammer T. Cloning and tissue-specific expression of a delta-COP homologue in a freshwater and a brackish water-adapted strain of rainbow trout (Oncorhynchus mykiss). Genes Genet Syst. 2009;84:239-43 pubmed
    ..Quantitative Real-Time RT-PCR revealed that delta-COP is differentially expressed in liver and gill tissue of two rainbow trout strains, the freshwater strain STEELHEAD and the brackish water-adapted strain BORN. ..
  2. Buffa L, Fuchs E, Pietropaolo M, Barr F, Solimena M. ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells. Eur J Cell Biol. 2008;87:197-209 pubmed publisher
    ..Taken together, these data identify ICA69 as a novel Rab2 effector and point to its role in regulating the early transport of insulin secretory granule proteins. ..
  3. Zhao L, Helms J, Brugger B, Harter C, Martoglio B, Graf R, et al. Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta. Proc Natl Acad Sci U S A. 1997;94:4418-23 pubmed
    ..These data implicate a bivalent interaction of the complex with the donor membrane during vesicle formation. ..
  4. Feurle G. Xenin--a review. Peptides. 1998;19:609-15 pubmed
    ..The physiological role of the peptide xenin is not known. ..
  5. Michelsen K, Schmid V, Metz J, Heusser K, Liebel U, Schwede T, et al. Novel cargo-binding site in the beta and delta subunits of coatomer. J Cell Biol. 2007;179:209-17 pubmed
    ..A homology model of the COPI trunk domain illustrates the recognition of R-based signals by COPI. ..
  6. Ballensiefen W, Ossipov D, Schmitt H. Recycling of the yeast v-SNARE Sec22p involves COPI-proteins and the ER transmembrane proteins Ufe1p and Sec20p. J Cell Sci. 1998;111 ( Pt 11):1507-20 pubmed
    ..These results show consistently that Sec22p recycles from the Golgi back to the ER and that this recycling involves retrograde COPI vesicles. ..
  7. Bremser M, Nickel W, Schweikert M, Ravazzola M, Amherdt M, Hughes C, et al. Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. Cell. 1999;96:495-506 pubmed
  8. Béthune J, Kol M, Hoffmann J, Reckmann I, Brugger B, Wieland F. Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins. Mol Cell Biol. 2006;26:8011-21 pubmed
    ..In contrast, ER-resident cargos bind to coatomer as monomers and to sites other than gamma-COP. The COPI coat therefore discriminates between p24 proteins and ER-resident proteins by differential binding involving distinct subunits. ..
  9. Matanis T, Akhmanova A, Wulf P, del Nery E, Weide T, Stepanova T, et al. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat Cell Biol. 2002;4:986-92 pubmed
    ..These data suggest that coordinated action between Rab6a, BICD and the dynein-dynactin complex controls COPI-independent Golgi-ER transport. ..

More Information


  1. Mohrs M, Janssen K, Kreis T, Noegel A, Schleicher M. Cloning and characterization of beta-COP from Dictyostelium discoideum. Eur J Cell Biol. 2000;79:350-7 pubmed
    ..However, upon DMSO treatment we observed a reversible disassembly of the Golgi apparatus. In mammalian cells DMSO treatment had a similar effect on beta-COP distribution...
  2. Andag U, Neumann T, Schmitt H. The coatomer-interacting protein Dsl1p is required for Golgi-to-endoplasmic reticulum retrieval in yeast. J Biol Chem. 2001;276:39150-60 pubmed
    ..Furthermore, we demonstrate that Dsl1p is a peripheral membrane protein, which in vitro specifically binds to coatomer, the major component of the protein coat of COPI vesicles. ..
  3. Blagitko N, Schulz U, Schinzel A, Ropers H, Kalscheuer V. gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome. Hum Mol Genet. 1999;8:2387-96 pubmed
    ..Together, gamma 2-COP and MEST constitute a novel imprinting cluster in the human genome that may contain other, as yet unknown, imprinted genes. ..
  4. Sun Z, Anderl F, Fröhlich K, Zhao L, Hanke S, Brugger B, et al. Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. Traffic. 2007;8:582-93 pubmed
    ..These interactions are located within the core, adaptor-like domain of coatomer, indicating an organizational similarity between the COP I coat and clathrin adaptor complexes. ..
  5. Lay D, Gorgas K, Just W. Peroxisome biogenesis: where Arf and coatomer might be involved. Biochim Biophys Acta. 2006;1763:1678-87 pubmed
  6. Sytnyk V, Leshchyns ka I, Delling M, Dityateva G, Dityatev A, Schachner M. Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts. J Cell Biol. 2002;159:649-61 pubmed
    ..The accumulation of TGN organelles at contacts with NCAM-deficient neurons is reduced when compared with wild-type cells, suggesting that NCAM mediates the anchoring of intracellular organelles in nascent synapses. ..
  7. Pepperkok R, Whitney J, Gomez M, Kreis T. COPI vesicles accumulating in the presence of a GTP restricted arf1 mutant are depleted of anterograde and retrograde cargo. J Cell Sci. 2000;113 ( Pt 1):135-44 pubmed
  8. Stenbeck G, Harter C, Brecht A, Herrmann D, Lottspeich F, Orci L, et al. beta'-COP, a novel subunit of coatomer. EMBO J. 1993;12:2841-5 pubmed
    ..This subunit occurs in amounts stoichiometric to the established COPs both in the coatomer and in nonclathrin-coated vesicles and shows homology to the beta-subunits of trimeric G proteins. ..
  9. Fullekrug J, Scheiffele P, Simons K. VIP36 localisation to the early secretory pathway. J Cell Sci. 1999;112 ( Pt 17):2813-21 pubmed
    ..Furthermore, after brefeldin A treatment VIP36 is segregated from resident Golgi proteins and codistributes with ER-Golgi recycling proteins. ..
  10. Reinhard C, Harter C, Bremser M, Brugger B, Sohn K, Helms J, et al. Receptor-induced polymerization of coatomer. Proc Natl Acad Sci U S A. 1999;96:1224-8 pubmed
    ..Based on these results, we propose a mechanism by which the induced conformational change of coatomer results in its polymerization, and thus drives formation of the bud on the Golgi membrane during biogenesis of a COPI vesicle. ..
  11. Harter C, Wieland F. A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer. Proc Natl Acad Sci U S A. 1998;95:11649-54 pubmed
    ..We suggest that, under physiological conditions, interaction of coatomer with both endoplasmic reticulum retrieval motifs and the cytoplasmic domain of p23 is mediated by gamma-COP. ..
  12. Passreiter M, Anton M, Lay D, Frank R, Harter C, Wieland F, et al. Peroxisome biogenesis: involvement of ARF and coatomer. J Cell Biol. 1998;141:373-83 pubmed
  13. Sohn K, Orci L, Ravazzola M, Amherdt M, Bremser M, Lottspeich F, et al. A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding. J Cell Biol. 1996;135:1239-48 pubmed
    ..From these data we conclude that p23 represents a Golgi-specific receptor for coatomer involved in the formation of COPI-coated vesicles...
  14. Harter C, Pavel J, Coccia F, Draken E, Wegehingel S, Tschochner H, et al. Nonclathrin coat protein gamma, a subunit of coatomer, binds to the cytoplasmic dilysine motif of membrane proteins of the early secretory pathway. Proc Natl Acad Sci U S A. 1996;93:1902-6 pubmed