Experts and Doctors on cholesterol esters in Austria
Topic: cholesterol esters
Gander R, Eller P, Kaser S, Theurl I, Walter D, Sauper T, et al
. Molecular characterization of rabbit phospholipid transfer protein: choroid plexus and ependyma synthesize high levels of phospholipid transfer protein. J Lipid Res. 2002;43:636-45 pubmed
Strauss J, Zimmermann R, Hrzenjak A, Zhou Y, Kratky D, Levak Frank S, et al
. Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity. Biochem J. 2002;368:69-79 pubmed
..Thus our results demonstrate that EDL mediates both HDL binding and uptake, and the selective uptake of HDL-CE, independently of lipolysis and CLA-1. ..
Marsche G, Zimmermann R, Horiuchi S, Tandon N, Sattler W, Malle E. Class B scavenger receptors CD36 and SR-BI are receptors for hypochlorite-modified low density lipoprotein. J Biol Chem. 2003;278:47562-70 pubmed
..Experiments with Chinese hamster ovary cells overexpressing scavenger receptor class A, type I, confirmed that LDL modified at physiologically relevant HOCl concentrations is not recognized by this receptor. ..
Rhode S, Breuer A, Hesse J, Sonnleitner M, Pagler T, Doringer M, et al
. Visualization of the uptake of individual HDL particles in living cells via the scavenger receptor class B type I. Cell Biochem Biophys. 2004;41:343-56 pubmed
..Costaining with organelle markers confirmed the involvement of an acidic compartment and the Golgi apparatus in the uptake process; finally, resecretion of the HDL particles was observed. ..
Pagler T, Rhode S, Neuhofer A, Laggner H, Strobl W, Hinterndorfer C, et al
. SR-BI-mediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol efflux. J Biol Chem. 2006;281:11193-204 pubmed
..Finally, we present evidence that HDL retroendocytosis represents one of the pathways for cholesterol efflux. ..