Genomes and Genes
Experts and Doctors on chemotaxis in Germany
Publications106 found, 100 shown here
- Röhrl J, Yang D, Oppenheim J, Hehlgans T. Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3. J Biol Chem. 2008;283:5414-9 pubmed publisher..In addition, both hBD3 and mBD14 were chemotactic for freshly isolated mouse resident peritoneal cells. Thus, mBD14, based on structural and functional similarities, appears to be an orthologue of hBD3. ..
- Daum S, Schumann M, Mathea S, Aumüller T, Balsley M, Constant S, et al. Isoform-specific inhibition of cyclophilins. Biochemistry. 2009;48:6268-77 pubmed publisher..Inhibition of CypA- but not CypB-mediated chemotaxis of mouse CD4(+) T cells by the inhibitor provided biological proof of discrimination in vivo. ..
- Wenter R, Wanner G, Schüler D, Overmann J. Ultrastructure, tactic behaviour and potential for sulfate reduction of a novel multicellular magnetotactic prokaryote from North Sea sediments. Environ Microbiol. 2009;11:1493-505 pubmed publisher..By means of its coordinated magnetotaxis and chemotaxis, the novel type of MMP is well adapted to the steep chemical gradients which are characteristic for intertidal marine sediments. ..
- Wada H, Netz R. Model for self-propulsive helical filaments: kink-pair propagation. Phys Rev Lett. 2007;99:108102 pubmed..It is shown that the observed helical bacterial pitch angle psi approximately 35 degrees is optimized for maximal speed and efficiency. ..
- Rae R, Riebesell M, Dinkelacker I, Wang Q, Herrmann M, Weller A, et al. Isolation of naturally associated bacteria of necromenic Pristionchus nematodes and fitness consequences. J Exp Biol. 2008;211:1927-36 pubmed publisher..Bringing the nematode-bacterial interaction into the laboratory allows detailed functional studies, including the genetic manipulation of the interaction in both nematodes and bacteria. ..
- Paskauskas S, Parseliunas A, Kerkadze V, Nobiling R, Schmidt J, Ryschich E. Blockade of leukocyte haptokinesis and haptotaxis by ketoprofen, diclofenac and SC-560. BMC Immunol. 2011;12:64 pubmed publisher..NSAID strongly supress leukocyte migration. The results of the present study may have important clinical implications since blockade of leukocyte migration can be achieved after topical application of NSAID. ..
- Schuetz T, Becker S, Mang A, Toma A, Buzug T. A computational multiscale model of glioblastoma growth: regulation of cell migration and proliferation via microRNA-451, LKB1 and AMPK. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:6620-3 pubmed publisher..g. chemotactic movement) on the microscopic level. First results demonstrate that the computational model reproduces a tumor cell development comparable to that observed in in vitro experiments...
- Sauer B, Vogler R, von Wenckstern H, Fujii M, Anzano M, Glick A, et al. Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes. J Biol Chem. 2004;279:38471-9 pubmed
- Oleksiuk O, Jakovljevic V, Vladimirov N, Carvalho R, Paster E, Ryu W, et al. Thermal robustness of signaling in bacterial chemotaxis. Cell. 2011;145:312-21 pubmed publisher..Similar compensatory mechanisms are expected to ensure thermal robustness in other systems. ..
- Bauhofer A, Huttel M, Lorenz W, Sessler D, Torossian A. Differential effects of antibiotics in combination with G-CSF on survival and polymorphonuclear granulocyte cell functions in septic rats. BMC Infect Dis. 2008;8:55 pubmed publisher..Therefore, the selection of the antibiotic for combination with G-CSF in sepsis treatment should be guided not only by the bacteria to be eliminated, but also by the effects on antimicrobial functions of PMNs and the cytokine response. ..
- Gillitzer R, Goebeler M. Chemokines in cutaneous wound healing. J Leukoc Biol. 2001;69:513-21 pubmed..This review will focus preferentially on the role of chemokines during skin wound healing and intends to provide an update on the multiple functions of individual chemokines during the phases of wound repair. ..
- Böttcher R, Niehrs C. Fibroblast growth factor signaling during early vertebrate development. Endocr Rev. 2005;26:63-77 pubmed..We focus on FGF signaling during early embryonic processes in vertebrates, such as induction and patterning of the three germ layers as well as its function in the control of morphogenetic movements. ..
- Abele S, Spriewald B, Ramsperger Gleixner M, Wollin M, Hiemann N, Nieswandt B, et al. Attenuation of transplant arteriosclerosis with clopidogrel is associated with a reduction of infiltrating dendritic cells and macrophages in murine aortic allografts. Transplantation. 2009;87:207-16 pubmed publisher
- Hackel D, PflÃ¼cke D, Neumann A, Viebahn J, Mousa S, Wischmeyer E, et al. The connection of monocytes and reactive oxygen species in pain. PLoS ONE. 2013;8:e63564 pubmed publisher..The study further supports the impact of CCL2 and ROS as potential targets in pain therapy. ..
- Blusch J, Nellen W. Folate responsiveness during growth and development of Dictyostelium: separate but related pathways control chemotaxis and gene regulation. Mol Microbiol. 1994;11:331-5 pubmed..Therefore we conclude that the pathways for chemotaxis and for gene regulation diverge downstream of a common receptor type...
- Bretschneider T, Diez S, Anderson K, Heuser J, Clarke M, Müller Taubenberger A, et al. Dynamic actin patterns and Arp2/3 assembly at the substrate-attached surface of motile cells. Curr Biol. 2004;14:1-10 pubmed..These primordia would represent an activated state of the actin system and enable cells to respond within seconds to local stimuli by chemotaxis or phagocytic-cup formation. ..
- Dietel B, Cicha I, Voskens C, Verhoeven E, Achenbach S, Garlichs C. Decreased numbers of regulatory T cells are associated with human atherosclerotic lesion vulnerability and inversely correlate with infiltrated mature dendritic cells. Atherosclerosis. 2013;230:92-9 pubmed publisher..The results of our study provide novel insights in the direct interaction of mature DCs and Treg in plaque inflammation and stability. ..
- Kokoeva M, Storch K, Klein C, Oesterhelt D. A novel mode of sensory transduction in archaea: binding protein-mediated chemotaxis towards osmoprotectants and amino acids. EMBO J. 2002;21:2312-22 pubmed publisher..salinarum utilizes these solutes for osmotic adaptation...
- Brack A, Rittner H, Machelska H, Shaqura M, Mousa S, Labuz D, et al. Endogenous peripheral antinociception in early inflammation is not limited by the number of opioid-containing leukocytes but by opioid receptor expression. Pain. 2004;108:67-75 pubmed..05, t-test). In summary, antinociception during early inflammation is apparently not limited by the number of opioid-containing leukocytes but by OR availability. ..
- Thiem S, Sourjik V. Stochastic assembly of chemoreceptor clusters in Escherichia coli. Mol Microbiol. 2008;68:1228-36 pubmed publisher..Upon subsequent anchorage to defined lateral sites, clusters grow with rates that inversely depend on their size, and become polar upon several rounds of cell division. ..
- Dudanova I, Gatto G, Klein R. GDNF acts as a chemoattractant to support ephrinA-induced repulsion of limb motor axons. Curr Biol. 2010;20:2150-6 pubmed publisher..GDNF also acts in a permissive manner by reducing ephrinA-induced collapse and keeping the axons in a growth-competent state. This is the first example of two opposing cues promoting the same trajectory choice at an intermediate target. ..
- Kollmann M, Løvdok L, Bartholomé K, Timmer J, Sourjik V. Design principles of a bacterial signalling network. Nature. 2005;438:504-7 pubmed..Moreover, the underlying topological design principles compensating for intercellular variations seem to be highly conserved among bacterial chemosensory systems. ..
- Hildebrand E, Kaupp U. Sperm chemotaxis: a primer. Ann N Y Acad Sci. 2005;1061:221-5 pubmed..In this paper the cellular pathway and the motor response during chemotaxis of sperm from sea urchin and starfish are briefly outlined. ..
- Schulz H, Jorgensen B. Big bacteria. Annu Rev Microbiol. 2001;55:105-37 pubmed..In fact, a close relative, T. namibiensis, can probably respire in the sulfidic mud for several months before again filling up their large vacuoles with nitrate...
- Höpken U, Foss H, Meyer D, Hinz M, Leder K, Stein H, et al. Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs. Blood. 2002;99:1109-16 pubmed..Functionally, such differential chemokine receptor expression might contribute to specific localization and confinement of neoplastic cells within the target organs in the distinct HD entities. ..
- Jaganathan B, Ruester B, Dressel L, Stein S, Grez M, Seifried E, et al. Rho inhibition induces migration of mesenchymal stromal cells. Stem Cells. 2007;25:1966-74 pubmed..Disclosure of potential conflicts of interest is found at the end of this article. ..
- Hanley P, Xu Y, Kronlage M, Grobe K, Schön P, Song J, et al. Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility. Proc Natl Acad Sci U S A. 2010;107:12145-50 pubmed publisher..Thus, we identify the "motorized Rho inhibitor" Myo9b as a key molecular component required for spatially coordinated cell shape changes and motility. ..
- Isfort K, Ebert F, Bornhorst J, Sargin S, Kardakaris R, Pasparakis M, et al. Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. J Biol Chem. 2011;286:44776-87 pubmed publisher..We propose that ATP signaling is strictly autocrine or paracrine and that ATP and ADP may act as short-range "touch me" (rather than long-range find me) signals to promote phagocytic clearance via cell spreading. ..
- Block H, Stadtmann A, Riad D, Rossaint J, Sohlbach C, Germena G, et al. Gnb isoforms control a signaling pathway comprising Rac1, PlcÎ²2, and PlcÎ²3 leading to LFA-1 activation and neutrophil arrest in vivo. Blood. 2016;127:314-24 pubmed publisher..Taken together, we demonstrated that all Gnb isoforms are required for chemokine-induced downstream signaling, and Rac1, PlcÎ²2, and PlcÎ²3 are critically involved in integrin activation and leukocyte arrest. ..
- de Hostos E, Rehfuess C, Bradtke B, Waddell D, Albrecht R, Murphy J, et al. Dictyostelium mutants lacking the cytoskeletal protein coronin are defective in cytokinesis and cell motility. J Cell Biol. 1993;120:163-73 pubmed..This contrasts with the localization of myosin II in the cleavage furrow and suggests that coronin functions independently of the conventional myosin in facilitating cytokinesis. ..
- Grabe K, Haas W. Navigation within host tissues: Schistosoma mansoni and Trichobilharzia ocellata schistosomula respond to chemical gradients. Int J Parasitol. 2004;34:927-34 pubmed
- Scheffel A, Gruska M, Faivre D, Linaroudis A, Plitzko J, Schüler D. An acidic protein aligns magnetosomes along a filamentous structure in magnetotactic bacteria. Nature. 2006;440:110-4 pubmed..According to our hypothesis, magnetosome architecture represents one of the highest structural levels achieved in prokaryotic cells. ..
- Schlorke D, Thomas L, Samsonov S, Huster D, Arnhold J, Pichert A. The influence of glycosaminoglycans on IL-8-mediated functions of neutrophils. Carbohydr Res. 2012;356:196-203 pubmed publisher..This work provides a representative example of how protein functions can be regulated by different GAGs of the ECM. ..
- Kusch A, Tkachuk S, Haller H, Dietz R, Gulba D, Lipp M, et al. Urokinase stimulates human vascular smooth muscle cell migration via a phosphatidylinositol 3-kinase-Tyk2 interaction. J Biol Chem. 2000;275:39466-73 pubmed..Our results underscore the versatile function of Tyk2 in uPA-related intracellular signaling and indicate that PI3-K plays a selective role in the regulation of VSMC migration. ..
- Cypionka H. Oxygen respiration by desulfovibrio species. Annu Rev Microbiol. 2000;54:827-48 pubmed..Behavioral responses to oxygen include aggregation, migration to anoxic zones, and aerotaxis. The latter leads to band formation in oxygen-containing zones at concentrations of </=20% air saturation. ..
- Dichmann S, Herouy Y, Purlis D, Rheinen H, Gebicke Härter P, Norgauer J. Fractalkine induces chemotaxis and actin polymerization in human dendritic cells. Inflamm Res. 2001;50:529-33 pubmed
- Rivero F, Illenberger D, Somesh B, Dislich H, Adam N, Meyer A. Defects in cytokinesis, actin reorganization and the contractile vacuole in cells deficient in RhoGDI. EMBO J. 2002;21:4539-49 pubmed..Our results indicate that GDI1 plays a central role in the regulation of signal transduction cascades mediated by Rho GTPases. ..
- von Stebut E, Metz M, Milon G, Knop J, Maurer M. Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1alpha /beta released from neutrophils recruited by mast cell-derived TNFalpha. Blood. 2003;101:210-5 pubmed..These findings indicate that MPhi recruitment to cutaneous PAG- induced granulomas is the result of a sequence of inflammatory processes initiated by MC-derived TNFalpha followed by PMN influx and MIP-1a/beta release. ..
- Henschler R, Piiper A, Bistrian R, Möbest D. SDF-1alpha-induced intracellular calcium transient involves Rho GTPase signalling and is required for migration of hematopoietic progenitor cells. Biochem Biophys Res Commun. 2003;311:1067-71 pubmed..Our data indicate that the small GTPase Rho is required for the induction of Ca(2+) transients in HPC, which in turn are necessary for the coordinated migratory response of HPC both in vitro and in vivo. ..
- Marx N, Walcher D, Raichle C, Aleksic M, Bach H, Grüb M, et al. C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro. Arterioscler Thromb Vasc Biol. 2004;24:540-5 pubmed..These data support the hypothesis that C-peptide may play an active role in atherogenesis in diabetic patients and suggest a new mechanism for accelerated arterial disease in diabetes. ..
- Sturm A, Baumgart D, d Heureuse J, Hotz A, Wiedenmann B, Dignass A. CXCL8 modulates human intestinal epithelial cells through a CXCR1 dependent pathway. Cytokine. 2005;29:42-8 pubmed..CXCL8 exerts functional effects on intestinal epithelial cells that may be relevant for intestinal inflammation and mucosal healing. ..
- Radeke H, von Wenckstern H, Stoidtner K, Sauer B, Hammer S, Kleuser B. Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52. J Immunol. 2005;174:2778-86 pubmed..Thus, our data indicate a cross-communication between S1P and TGF-beta signaling that might be relevant for more than only migratory activities of immature LC. ..
- Popovic M, Laumonnier Y, Burysek L, Syrovets T, Simmet T. Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration. J Leukoc Biol. 2008;84:215-23 pubmed publisher..Thus, the thrombin-induced monocyte/endothelial cell cross-talk mediated by increased CX3CL1 expression potentiates the CCL2 chemokine generation that might contribute to the recruitment of monocytes into inflamed areas. ..
- Rae R, Robertson J, Wilson M. Chemoattraction and host preference of the gastropod parasitic nematode Phasmarhabditis hermaphrodita. J Parasitol. 2009;95:517-26 pubmed publisher..These necromenic species represent ideal hosts for P. hermaphrodita in terms of providing protection against abiotic and biotic factors as well as transport to many diverse areas. ..
- Hoermannsperger G, Hörmannsperger G, Clavel T, Hoffmann M, Reiff C, Kelly D, et al. Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: impact on chronic inflammation. PLoS ONE. 2009;4:e4365 pubmed publisher..Furthermore, we revealed post-translational degradation of IP-10 protein in IEC to be the molecular mechanism underlying the anti-inflammatory effect. ..
- Shina M, Unal C, Eichinger L, Müller Taubenberger A, Schleicher M, Steinert M, et al. A Coronin7 homolog with functions in actin-driven processes. J Biol Chem. 2010;285:9249-61 pubmed publisher..We propose that the CRN7 role in chemotaxis and phagocytosis is through its effect on the actin cytoskeleton. ..
- Shina M, Müller Taubenberger A, Unal C, Schleicher M, Steinert M, Eichinger L, et al. Redundant and unique roles of coronin proteins in Dictyostelium. Cell Mol Life Sci. 2011;68:303-13 pubmed publisher..Rather, they often act antagonistically, which is in accordance with their proposed roles in the actin cytoskeleton where CRN12 acts in actin disassembly whereas CRN7 stabilizes actin filaments and protects them from disassembly. ..
- Reher T, Neumann D, Buschauer A, Seifert R. Incomplete activation of human eosinophils via the histamine H4-receptor: evidence for ligand-specific receptor conformations. Biochem Pharmacol. 2012;84:192-203 pubmed publisher..This indicates functional selectivity of H(4)R ligands, thus ligand-specific stabilization of distinct receptor conformations, inducing distinct biological responses. ..
- Arhzaouy K, Strucksberg K, Tung S, Tangavelou K, Stumpf M, Faix J, et al. Heteromeric p97/p97R155C complexes induce dominant negative changes in wild-type and autophagy 9-deficient Dictyostelium strains. PLoS ONE. 2012;7:e46879 pubmed publisher..Based on findings in the single versus the double mutants we propose a novel mode of p97 interaction with the core autophagy protein ATG9 which is based on mutual inhibition. ..
- Vlaicu P, Mertins P, Mayr T, Widschwendter P, Ataseven B, Högel B, et al. Monocytes/macrophages support mammary tumor invasivity by co-secreting lineage-specific EGFR ligands and a STAT3 activator. BMC Cancer. 2013;13:197 pubmed publisher..We sought to analyze which EGFR- and STAT3-activating factors are secreted by monocytes/macrophages exposed to tumor cell-secreted factors...
- Rudolph J, Tolliday N, Schmitt C, Schuster S, Oesterhelt D. Phosphorylation in halobacterial signal transduction. EMBO J. 1995;14:4249-57 pubmed..The mechanism of chemo- and phototactic signal transduction in the Archaeon H.salinarium, therefore, is similar to the two-component signaling system known from chemotaxis in the eubacterium E.coli...
- Rudolph J, Oesterhelt D. Chemotaxis and phototaxis require a CheA histidine kinase in the archaeon Halobacterium salinarium. EMBO J. 1995;14:667-73 pubmed..This indicates that CheAH.s. plays a crucial role in chemical and light signal integration, presumably interacting with at least two phototransducers and a number of chemoreceptors...
- Lux R, Jahreis K, Bettenbrock K, Parkinson J, Lengeler J. Coupling the phosphotransferase system and the methyl-accepting chemotaxis protein-dependent chemotaxis signaling pathways of Escherichia coli. Proc Natl Acad Sci U S A. 1995;92:11583-7 pubmed..Consequently, unphosphorylated EI builds up and inhibits CheA autophosphorylation. This slows the flow of phosphates to CheY, eliciting an up-gradient swimming response by the cell. ..
- Haberl B, Korner M, Spengler Y, Hertel J, Kalbe M, Haas W. Host-finding in Echinostoma caproni: miracidia and cercariae use different signals to identify the same snail species. Parasitology. 2000;120 ( Pt 5):479-86 pubmed..This indicates an independent evolution of host-finding mechanisms in the two parasite stages...
- Idzko M, Panther E, Corinti S, Morelli A, Ferrari D, Herouy Y, et al. Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. FASEB J. 2002;16:625-7 pubmed..In summary, our study implicates that S1P might regulate the trafficking of DC and ultimately favor Th2 lymphocyte-dominated immunity. ..
- Sourjik V. Receptor clustering and signal processing in E. coli chemotaxis. Trends Microbiol. 2004;12:569-76 pubmed..Recent advances in computer modeling and in quantitative experimental analysis suggest that cooperative protein interactions in receptor clusters play a crucial role in the signal processing during bacterial chemotaxis. ..
- Attmannspacher U, Scharf B, Schmitt R. Control of speed modulation (chemokinesis) in the unidirectional rotary motor of Sinorhizobium meliloti. Mol Microbiol. 2005;56:708-18 pubmed publisher..The data infer a novel mechanism of flagellar speed control by electrostatic forces acting at the rotor/stator interface. These features have been integrated into a working model of the speed-modulating rotary motor...
- Michalodimitrakis K, Sourjik V, Serrano L. Plasticity in amino acid sensing of the chimeric receptor Taz. Mol Microbiol. 2005;58:257-66 pubmed..Our results show the exquisite sensitivity of chemotactic receptors. Small conformational changes induced by making the chimera may have changed the way it responds to different amino acids. ..
- Somesh B, Vlahou G, Iijima M, Insall R, Devreotes P, Rivero F. RacG regulates morphology, phagocytosis, and chemotaxis. Eukaryot Cell. 2006;5:1648-63 pubmed..We hypothesize that RacG interacts with a subset of effectors, in particular those concerned with shape, motility, and phagocytosis. ..
- Chavakis E, Carmona G, Urbich C, Göttig S, Henschler R, Penninger J, et al. Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells. Circ Res. 2008;102:942-9 pubmed publisher..In conclusion, PI3Kgamma is integral to the integrin-dependent homing of progenitor cells. ..
- Schulmeister S, Ruttorf M, Thiem S, Kentner D, Lebiedz D, Sourjik V. Protein exchange dynamics at chemoreceptor clusters in Escherichia coli. Proc Natl Acad Sci U S A. 2008;105:6403-8 pubmed publisher..Our results indicate that the rates of protein turnover at the cluster have evolved to ensure optimal performance of the chemotaxis pathway. ..
- Li X, Syrovets T, Genze F, Pitterle K, Oberhuber A, Orend K, et al. Plasmin triggers chemotaxis of monocyte-derived dendritic cells through an Akt2-dependent pathway and promotes a T-helper type-1 response. Arterioscler Thromb Vasc Biol. 2010;30:582-90 pubmed publisher..Plasmin generation in the atherosclerotic vessel wall might contribute to accumulation of DC, activation of the adaptive immune response, and aggravation of atherosclerosis. ..
- Schlesner M, Miller A, Besir H, Aivaliotis M, Streif J, Scheffer B, et al. The protein interaction network of a taxis signal transduction system in a halophilic archaeon. BMC Microbiol. 2012;12:272 pubmed publisher..Secondly, we propose a hypothetical feedback loop from the response regulator to Htr methylation made from the CheC proteins, CheD and CheB, which might contribute to adaptation analogous to the CheC/CheD system of B. subtilis. ..
- Segerer S, Martignoni F, Bogdan A, Muller N, Kapp M, Dietl J, et al. Thrombopoietin modulates the proliferation, migration and cytokine profile of decidual cell subsets during early gestation. Mol Hum Reprod. 2013;19:361-8 pubmed publisher..Thus, we here identified TPO as a novel factor modulating the proliferation, migration and possibly cytokine secretion of decidual cell subsets. ..
- Haasters F, Prall W, Westphal I, Bocker W, Padula D, Mutschler W, et al. Overexpression of dnIKK in mesenchymal stem cells leads to increased migration and decreased invasion upon TNF? stimulation. Biochem Biophys Res Commun. 2013;436:265-70 pubmed publisher..These findings contribute to a deeper understanding of MSC's biological properties orchestrating the complex processes of stem cell recruitment and homing. ..
- Binamé F, Sakry D, Dimou L, Jolivel V, Trotter J. NG2 regulates directional migration of oligodendrocyte precursor cells via Rho GTPases and polarity complex proteins. J Neurosci. 2013;33:10858-74 pubmed publisher..This work also reveals CRB and PAR polarity complexes as new effectors of NG2 signaling in the establishment of front-rear polarity. ..
- Panther E, Idzko M, Herouy Y, Rheinen H, Gebicke Haerter P, Mrowietz U, et al. Expression and function of adenosine receptors in human dendritic cells. FASEB J. 2001;15:1963-70 pubmed..These effects can be explained by differential expression of adenosine receptor subtypes. ..
- Müller Taubenberger A, Lupas A, Li H, Ecke M, Simmeth E, Gerisch G. Calreticulin and calnexin in the endoplasmic reticulum are important for phagocytosis. EMBO J. 2001;20:6772-82 pubmed
- Debes G, Höpken U, Hamann A. In vivo differentiated cytokine-producing CD4(+) T cells express functional CCR7. J Immunol. 2002;168:5441-7 pubmed..These findings indicate that CD4(+) cells producing effector cytokines upon stimulation retain the capacity to recirculate through lymphoid tissues via CCR7. ..
- Schreiner T, Mohrs M, Blau Wasser R, von Krempelhuber A, Steinert M, Schleicher M, et al. Loss of the F-actin binding and vesicle-associated protein comitin leads to a phagocytosis defect. Eukaryot Cell. 2002;1:906-14 pubmed..The redistribution of comitin during hyperosmotic shock in wild-type cells and its presence on early phagosomes suggest a direct involvement of comitin in these processes. ..
- Müller Taubenberger A, Bretschneider T, Faix J, Konzok A, Simmeth E, Weber I. Differential localization of the Dictyostelium kinase DPAKa during cytokinesis and cell migration. J Muscle Res Cell Motil. 2002;23:751-63 pubmed..Therefore, DPAKa may play distinct roles in myosin II regulation during cell movement and cell division. ..
- Glaeser J, Overmann J. The significance of organic carbon compounds for in situ metabolism and chemotaxis of phototrophic consortia. Environ Microbiol. 2003;5:1053-63 pubmed..Thus, our results indicate that incorporation of 2-oxoglutarate by the central bacterium is regulated by the metabolic state of the green sulphur bacterial epibionts. ..
- Riepl H, Scharf B, Schmitt R, Kalbitzer H, Maurer T. Solution structures of the inactive and BeF3-activated response regulator CheY2. J Mol Biol. 2004;338:287-97 pubmed..We propose that these new features of response regulator activation, compared to other two-component systems, are the key for the observed unique phosphorylation, dephosphorylation and motor control mechanisms in S.meliloti. ..
- Diez S, Gerisch G, Anderson K, Müller Taubenberger A, Bretschneider T. Subsecond reorganization of the actin network in cell motility and chemotaxis. Proc Natl Acad Sci U S A. 2005;102:7601-6 pubmed..We propose that high turnover rates of actin filaments confer the plasticity to the cell cortex that is required for rapid accommodation to external stimuli. ..
- Løvdok L, Kollmann M, Sourjik V. Co-expression of signaling proteins improves robustness of the bacterial chemotaxis pathway. J Biotechnol. 2007;129:173-80 pubmed..Although the design features that are responsible for this higher robustness still remain to be understood, our results stress the importance of a robust design of both native and synthetic signaling networks. ..
- Bernhagen J, Krohn R, Lue H, Gregory J, Zernecke A, Koenen R, et al. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med. 2007;13:587-96 pubmed..Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition. ..
- Orinska Z, Maurer M, Mirghomizadeh F, Bulanova E, Metz M, Nashkevich N, et al. IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities. Nat Med. 2007;13:927-34 pubmed..Our results identify an unexpected breach in MC-dependent innate immune defenses against sepsis and suggest that inhibiting intracellular IL-15 in MCs may improve survival from sepsis. ..
- Glaser T, Brose C, Franceschini I, Hamann K, Smorodchenko A, Zipp F, et al. Neural cell adhesion molecule polysialylation enhances the sensitivity of embryonic stem cell-derived neural precursors to migration guidance cues. Stem Cells. 2007;25:3016-25 pubmed..Disclosure of potential conflicts of interest is found at the end of this article. ..
- Mondal S, Bakthavatsalam D, Steimle P, Gassen B, Rivero F, Noegel A. Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions. J Cell Biol. 2008;181:747-60 pubmed publisher..Collectively, our results suggest that starvation signals through RasGEF Q to activate RasB, which then regulates processes requiring myosin II. ..
- Ryser M, Ugarte F, Lehmann R, Bornhauser M, Brenner S. S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing. Mol Immunol. 2008;46:166-71 pubmed publisher..Our data suggest that S1P(1) acts as an inhibitor of CXCR4-dependent migration of hematopoietic cells to sites of SDF-1 production. ..
- Schlesner M, Miller A, Streif S, Staudinger W, Müller J, Scheffer B, et al. Identification of Archaea-specific chemotaxis proteins which interact with the flagellar apparatus. BMC Microbiol. 2009;9:56 pubmed publisher..Altogether, these results demonstrate that, in the archaeal domain, previously unrecognized archaea-specific Che proteins are essential for relaying taxis signaling to the flagellar apparatus. ..
- Foryst Ludwig A, Hartge M, Clemenz M, Sprang C, Hess K, Marx N, et al. PPARgamma activation attenuates T-lymphocyte-dependent inflammation of adipose tissue and development of insulin resistance in obese mice. Cardiovasc Diabetol. 2010;9:64 pubmed publisher..Together the present study demonstrates a close connection between PPARgamma-mediated anti-inflammation in AT and systemic improvement of glucose metabolism identifying T-lymphocytes as one cellular mediator of PPARgamma´s action. ..
- Dreymueller D, Pruessmeyer J, Schumacher J, Fellendorf S, Hess F, Seifert A, et al. The metalloproteinase ADAM8 promotes leukocyte recruitment in vitro and in acute lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2017;313:L602-L614 pubmed publisher..Our study provides in vitro and in vivo evidence that ADAM8 on leukocytes holds a proinflammatory function in acute lung inflammation by promoting alveolar leukocyte recruitment. ..
- Weyand I, Godde M, Frings S, Weiner J, Muller F, Altenhofen W, et al. Cloning and functional expression of a cyclic-nucleotide-gated channel from mammalian sperm. Nature. 1994;368:859-63 pubmed..These channels might be involved in chemotaxis of sperm by controlling Ca2+ entry through a cyclic-nucleotide signalling pathway. ..
- Idzko M, Dichmann S, Ferrari D, Di Virgilio F, la Sala A, Girolomoni G, et al. Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. Blood. 2002;100:925-32 pubmed
- Khurana B, Khurana T, Khaire N, Noegel A. Functions of LIM proteins in cell polarity and chemotactic motility. EMBO J. 2002;21:5331-42 pubmed..Our results reveal both unique and overlapping roles for LimC and LimD, and suggest that both act directly on the actin cytoskeleton and provide rigidity to the cortex. ..
- Glaeser J, Overmann J. Biogeography, evolution, and diversity of epibionts in phototrophic consortia. Appl Environ Microbiol. 2004;70:4821-30 pubmed..The present study thus demonstrates that there is great diversity and nonrandom geographical distribution of phototrophic consortia in the natural environment...
- Lehmann M, Masanetz S, Kramer S, Erfle V. HIV-1 Nef upregulates CCL2/MCP-1 expression in astrocytes in a myristoylation- and calmodulin-dependent manner. J Cell Sci. 2006;119:4520-30 pubmed..In summary, we suggest that Nef-induced CCL2/MCP-1 expression in astrocytes contributes to infiltration of monocytes into the brain, and thereby to progression of HAD. ..