Genomes and Genes
Experts and Doctors on cell surface receptors in United States
Locale: United States
Topic: cell surface receptors
Publications187 found, 100 shown here
- Razonable R, Henault M, Lee L, Laethem C, Johnston P, Watson H, et al. Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2. Antimicrob Agents Chemother. 2005;49:1617-21 pubmed..Hence, TLR2-TLR1 coactivation serves as the underlying mechanism for the proinflammatory toxicities associated with AmB. ..
- Kang P, Azad A, Torrelles J, Kaufman T, Beharka A, Tibesar E, et al. The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J Exp Med. 2005;202:987-99 pubmed..0 +/- 5.1% vs. 38.6 +/- 0.6%). Thus, engagement of the MR by ManLAM during the phagocytic process directs M.tb to its initial phagosomal niche, thereby enhancing survival in human macrophages. ..
- Ariizumi T, Murase K, Sun T, Steber C. Proteolysis-independent downregulation of DELLA repression in Arabidopsis by the gibberellin receptor GIBBERELLIN INSENSITIVE DWARF1. Plant Cell. 2008;20:2447-59 pubmed publisher..Thus, a SLY1-independent mechanism for GA signaling may function without DELLA degradation. ..
- Olwin B, Burrus L, Zuber M, Lueddecke B. Characterization of a non-tyrosine kinase FGF-binding protein. Ann N Y Acad Sci. 1991;638:195-203 pubmed
- Bigas A, Martin D, Milner L. Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. Mol Cell Biol. 1998;18:2324-33 pubmed..These findings suggest that the multiple forms of Notch found in mammals have structural differences that allow their function to be modulated by specific differentiation signals. ..
- Li X, Tupper J, Bannerman D, Winn R, Rhodes C, Harlan J. Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells. Infect Immun. 2003;71:4414-20 pubmed..Further, these studies suggest that PI3-kinase is an important mediator of LPS and IL-1 beta signaling leading to NF-kappa B activation in endothelial cells and that Akt is necessary but not sufficient for NF-kappa B activation by TLR4. ..
- Maxwell J, Rossi R, McSorley S, Vella A. T cell clonal conditioning: a phase occurring early after antigen presentation but before clonal expansion is impacted by Toll-like receptor stimulation. J Immunol. 2004;172:248-59 pubmed..We postulate that this is a stage where T cells are either conditioned to survive or to delete depending upon the activation status of the innate immune system. ..
- Datta S, Novotny M, Li X, Tebo J, Hamilton T. Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA. J Immunol. 2004;173:2755-61 pubmed..Hence the ability of TIRs to signal stabilization of mRNA appears to be linked to the MyD88-dependent signaling pathway. ..
- McCarthy T, Torrelles J, MacFarlane A, Katawczik M, Kutzbach B, DesJardin L, et al. Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophages. Mol Microbiol. 2005;58:774-90 pubmed..We conclude that MtmanB encodes a functional PMM involved in the biosynthesis of mannosylated lipoglycans that participate in the association of mycobacteria with macrophage phagocytic receptors. ..
- Lipinski R, Gipp J, Zhang J, Doles J, Bushman W. Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling. Exp Cell Res. 2006;312:1925-38 pubmed
- Barnakov A, Barnakova L, Hazelbauer G. Comparison in vitro of a high- and a low-abundance chemoreceptor of Escherichia coli: similar kinase activation but different methyl-accepting activities. J Bacteriol. 1998;180:6713-8 pubmed..This addition enhanced the in vitro methyl-accepting activity of Trg 10-fold. ..
- Finkelstein L, Ney P, Liu Q, Paulson R, Correll P. Sf-Stk kinase activity and the Grb2 binding site are required for Epo-independent growth of primary erythroblasts infected with Friend virus. Oncogene. 2002;21:3562-70 pubmed..These data clearly demonstrate a requirement for signaling through Sf-Stk in the Epo-independent expansion of Friend virus-infected cells, and suggest a pivotal role for Grb2 in this response. ..
- Gu J, Johns A, Morser J, Dole W, Greaves D, Deng G. Urokinase plasminogen activator receptor promotes macrophage infiltration into the vascular wall of ApoE deficient mice. J Cell Physiol. 2005;204:73-82 pubmed..7 cells expressing human uPAR. These data demonstrate that uPAR plays a key role in promoting macrophage infiltration into the arterial wall of ApoE(-/-) mice. ..
- Gondi C, Lakka S, Dinh D, Olivero W, Gujrati M, Rao J. Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice. Clin Cancer Res. 2007;13:4051-60 pubmed..In conclusion, the plasmid-expressed RNAi targeting uPAR and uPA via the i.p. route has potential clinical applications for the treatment of glioma. ..
- Elco C, Guenther J, Williams B, Sen G. Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3, NF-kappaB, and interferon but not toll-like receptor 3. J Virol. 2005;79:3920-9 pubmed..Thus, IRF-3 can suppress the expression of NF-kappaB-dependent genes in SeV-infected cells. ..
- Fiedler S, Schillace R, Daniels C, Andrews S, Carr D. Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner. FEBS Lett. 2010;584:873-7 pubmed publisher..Collectively, these data suggest a possible mechanism for the targeting and integration of adenosine 3',5'-cyclic monophosphate (cAMP) and semaphorin signaling in immune cells. ..
- Giniger E. A role for Abl in Notch signaling. Neuron. 1998;20:667-81 pubmed..We therefore speculate that Disabled and Abl may play a role in Notch signaling in Drosophila axons, perhaps by binding to the Notch intracellular domain. ..
- Ciardi J, Tieman D, Jones J, Klee H. Reduced expression of the tomato ethylene receptor gene LeETR4 enhances the hypersensitive response to Xanthomonas campestris pv. vesicatoria. Mol Plant Microbe Interact. 2001;14:487-95 pubmed..Because the ethylene action inhibitor 1-methylcyclopropene alleviates the enhanced HR phenotype in LeETR4 antisense plants, these changes in pathogen response are a result of increased ethylene sensitivity. ..
- Smits P, Dy P, Mitra S, Lefebvre V. Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol. 2004;164:747-58 pubmed..In conclusion, Sox5 and Sox6 are needed for the establishment of multilayered growth plates, and thereby for proper and timely development of endochondral bones. ..
- Dharmasiri N, Dharmasiri S, Weijers D, Lechner E, Yamada M, Hobbie L, et al. Plant development is regulated by a family of auxin receptor F box proteins. Dev Cell. 2005;9:109-19 pubmed..Correspondingly, all TIR1/AFB proteins interact with BDL, and BDL is stabilized in triple mutant plants. Our results indicate that TIR1 and the AFB proteins collectively mediate auxin responses throughout plant development. ..
- Achkar C, Gong Q, Frankfater A, Bajkowski A. Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts. J Biol Chem. 1990;265:13650-4 pubmed
- McAndrew P, Frostholm A, Evans J, Zdilar D, Goldowitz D, Chiu I, et al. Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex. J Comp Neurol. 1998;391:444-55 pubmed..The restricted pattern of FGF-1 and RPTPrho implies that these molecules may have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex. ..
- Handlogten M, Huang C, Shiraishi N, Awata H, Miller R. The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway. J Biol Chem. 2001;276:13941-8 pubmed..These results demonstrate that the CaR activates cPLA(2) via a Galpha(q), PLC, Ca(2+)-CaM, and calmodulin-dependent protein kinase-dependent pathway that is independent the ERK pathway. ..
- Blankenship K, Williams J, Lawrence M, McLeish K, Dean W, Arthur J. The calcium-sensing receptor regulates calcium absorption in MDCK cells by inhibition of PMCA. Am J Physiol Renal Physiol. 2001;280:F815-22 pubmed..In addition, they provide a potential mechanism for the CaR to inhibit calcium transport, inhibition of PMCA. ..
- Jin H, Song Y, Boel G, Kochar J, Pancholi V. Group A streptococcal surface GAPDH, SDH, recognizes uPAR/CD87 as its receptor on the human pharyngeal cell and mediates bacterial adherence to host cells. J Mol Biol. 2005;350:27-41 pubmed..This interaction significantly contributes to bacterial adherence and thus may play a significant role in GAS pathogenesis by regulating intracellular signaling events in pharyngeal cells. ..
- Tong Y, Hota P, Penachioni J, Hamaneh M, Kim S, Alviani R, et al. Structure and function of the intracellular region of the plexin-b1 transmembrane receptor. J Biol Chem. 2009;284:35962-72 pubmed publisher..These findings suggest that the monomeric form of the intracellular region is primed for GAP activity and extend a model for plexin activation. ..
- Kirkpatrick L, Matzuk M, Dodds D, Perin M. Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. J Biol Chem. 2000;275:17786-92 pubmed..These processes are likely to directly effect the localization and function of neuronal pentraxins in neuronal uptake or synapse formation and remodeling. ..
- Van Brocklyn J, Letterle C, Snyder P, Prior T. Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. Cancer Lett. 2002;181:195-204 pubmed..Thus, S1P signaling through EDG receptors may contribute to glioblastoma growth in vivo. ..
- Davy A, Aubin J, Soriano P. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev. 2004;18:572-83 pubmed..Our results demonstrate that ephrin-B1 acts both as a ligand and as a receptor in a tissue-specific manner during embryogenesis. ..
- Coleman J, Semple Rowland S. GC1 deletion prevents light-dependent arrestin translocation in mouse cone photoreceptor cells. Invest Ophthalmol Vis Sci. 2005;46:12-6 pubmed..These results suggest that multiple, independent pathways regulate the translocation of phototransduction proteins and that GC1, and presumably cGMP, are of key importance in signaling the translocation of cone arrestin. ..
- Plager D, Kahl J, Asmann Y, Nilson A, Pallanch J, Friedman O, et al. Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. PLoS ONE. 2010;5:e11450 pubmed publisher..The identified gene expression changes provide additional diagnostic and therapeutic targets for aCRSwNP and other eosinophilic epithelial diseases. ..
- Griswold I, Zhou H, Matison M, Swanson R, McIntosh L, Simon M, et al. The solution structure and interactions of CheW from Thermotoga maritima. Nat Struct Biol. 2002;9:121-5 pubmed publisher..These results provide a structural basis for a model in which CheW acts as a molecular bridge between CheA and the cytoplasmic tails of the receptor...
- Horabin J, Walthall S, Vied C, Moses M. A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch. Development. 2003;130:6101-9 pubmed..These data suggest that the Hh pathway impacts on the sex determination process and vice versa and that the pathway may serve more functions than the regulation of Ci. ..
- Kunnimalaiyaan M, Traeger K, Chen H. Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells. Am J Physiol Gastrointest Liver Physiol. 2005;289:G636-42 pubmed..Therefore, manipulation of the Notch1 signaling pathway may be useful for expanding the targets for therapeutic and palliative treatment of patients with carcinoid tumors. ..
- Scott G, Jacobs S, Pentland A. sPLA2-X stimulates cutaneous melanocyte dendricity and pigmentation through a lysophosphatidylcholine-dependent mechanism. J Invest Dermatol. 2006;126:855-61 pubmed..Because secretory phospholipases are released during inflammation and are regulated by UV irradiation, our data suggest an important role for sPLA2-X in cutaneous pigmentation through the release of LPC. ..
- Morton G, Niswender K, Rhodes C, Myers M, Blevins J, Baskin D, et al. Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology. 2003;144:2016-24 pubmed..Adenoviral gene therapy is thus a viable strategy with which to study the physiological importance of specific molecules acting in discrete brain areas. ..
- Rosdahl J, Mourton T, Brady Kalnay S. Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. Mol Cell Neurosci. 2002;19:292-306 pubmed..These results suggest that PTPmu signaling via RACK1 requires PKCdelta activity to promote neurite outgrowth. ..
- Gudz T, Schneider T, Haas T, Macklin W. Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes. J Neurosci. 2002;22:7398-407 pubmed..These data establish a novel function for PLP as a part of the integrin signaling complex in oligodendrocytes and suggest that neurotransmitter-mediated integrin receptor signaling may be involved in myelinogenesis. ..
- Vielmetter J, Kayyem J, Roman J, Dreyer W. Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. J Cell Biol. 1994;127:2009-20 pubmed..Since neogenin is expressed on growing neurites and downregulated at termination of neurite growth, it may also play an important role in many of the complex functional aspects of neurite extension and intercellular signaling. ..
- Bocchetta M, Miele L, Pass H, Carbone M. Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells. Oncogene. 2003;22:81-9 pubmed..Our finding is relevant to the process of SV40-mediated human cell transformation, an effect that cannot be accounted for solely by SV40-Tag inhibition of Rb and p53. ..
- Cox E, Bennin D, Doan A, O TOOLE T, Huttenlocher A. RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site. Mol Biol Cell. 2003;14:658-69 pubmed..Together, these findings suggest that RACK1 regulates adhesion, protrusion, and chemotactic migration through its interaction with Src. ..
- Sarkar S, Peters K, Elco C, Sakamoto S, Pal S, Sen G. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol. 2004;11:1060-7 pubmed..Thus, the PI3K-Akt pathway plays an essential role in TLR3-mediated gene induction. ..
- Wayner E, Carter W, Piotrowicz R, Kunicki T. The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platele. J Cell Biol. 1988;107:1881-91 pubmed..These results show that multiple ECMRs function in combination to mediate cell adhesion to complex EMC templates and predicts that variation in ECM composition and ECMR expression may direct cell localization to specific tissue domains. ..
- Naik U, Eckfeld K. Junctional adhesion molecule 1 (JAM-1). J Biol Regul Homeost Agents. 2003;17:341-7 pubmed..Further study of the mechanism of JAM-1 action within these diverse systems may demonstrate that JAM-1 is a key player in many different cellular functions. ..
- Pritchard J, Olson J. Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas. Cancer Genet Cytogenet. 2008;180:47-50 pubmed..Future directions include examination of distal regions of the PTCHlb promoter as well as alternative exon variants, most notably the CpG island containing PTCH1-1C promoter. ..
- Navaratnarajah C, Vongpunsawad S, Oezguen N, Stehle T, Braun W, Hashiguchi T, et al. Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150). J Biol Chem. 2008;283:11763-71 pubmed publisher..Our study sets a structure-based stage for understanding how the SLAM-elicited conformational changes travel through the H-protein ectodomain before triggering fusion protein unfolding and membrane fusion. ..
- Li J, Li G, Weis R. The serine chemoreceptor from Escherichia coli is methylated through an inter-dimer process. Biochemistry. 1997;36:11851-7 pubmed..These results demonstrate a role for inter-dimer interactions in transmembrane signaling. ..
- Ma Q, Chen Z, del Barco Barrantes I, de la Pompa J, Anderson D. neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron. 1998;20:469-82 pubmed..1996), these data and those of Fode et al. (1998 [this issue of Neuron]) identify ngns as vertebrate neuronal determination genes, analogous to myoD and myf5 in myogenesis. ..
- Krebs L, Arnold A. Molecular basis of hyperparathyroidism and potential targets for drug development. Curr Drug Targets Immune Endocr Metabol Disord. 2002;2:167-79 pubmed..Attempts to identify new therapies based specifically on the defective pathways in HPT could complement or eventually supplant traditional approaches. ..
- Nguyen L, Bradfield C. The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol. 2008;21:102-16 pubmed..In light of the essential function of the AHR in embryonic development, we discuss the candidacy of each of these compounds as physiologically important activators. ..
- You T, Lee M, Jenkins J, Alzate O, Dean D. Blocking binding of Bacillus thuringiensis Cry1Aa to Bombyx mori cadherin receptor results in only a minor reduction of toxicity. BMC Biochem. 2008;9:3 pubmed publisher..The results identify a novel receptor-binding epitope and demonstrate that virtual elimination of binding to cadherin BR-175 does not completely remove toxicity in the case of B. mori. ..
- Klueg K, Parody T, Muskavitch M. Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development. Mol Biol Cell. 1998;9:1709-23 pubmed..Cell culture experiments imply that full-length Delta is taken up by Notch-expressing cells. We present evidence that suggests this uptake occurs by a nonphagocytic mechanism. ..
- Stein T, Anders N, DeCarli C, Chan S, Mattson M, Johnson J. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci. 2004;24:7707-17 pubmed..Therefore, the elevated expression of transthyretin is mediated by sAPPalpha and protects APP(Sw) mice from developing many of the neuropathologies observed in AD. ..
- Gondi C, Dinh D, Gujrati M, Rao J. Simultaneous downregulation of uPAR and MMP-9 induces overexpression of the FADD-associated protein RIP and activates caspase 9-mediated apoptosis in gliomas. Int J Oncol. 2008;33:783-90 pubmed..Based on our results we conclude that the simultaneous downregulation of uPAR and MMP-9 induces apoptosome-mediated apoptosis. ..
- Xu T, Wen M, Nagawa S, Fu Y, Chen J, Wu M, et al. Cell surface- and rho GTPase-based auxin signaling controls cellular interdigitation in Arabidopsis. Cell. 2010;143:99-110 pubmed publisher..These findings reveal Rho GTPase-based auxin-signaling mechanisms, which modulate the spatial coordination of cell expansion across a field of cells. ..
- Lashbrook C, Tieman D, Klee H. Differential regulation of the tomato ETR gene family throughout plant development. Plant J. 1998;15:243-52 pubmed..Furthermore, the abundance of mRNAs for all three LeETR genes remained uniform in multiple plant tissues experiencing marked changes in ethylene sensitivity, including the cell separation layer throughout tomato flower abscission. ..
- Taghon T, David E, Zuniga Pflucker J, Rothenberg E. Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. Genes Dev. 2005;19:965-78 pubmed
- Aimanova K, Zhuang M, Gill S. Expression of Cry1Ac cadherin receptors in insect midgut and cell lines. J Invertebr Pathol. 2006;92:178-87 pubmed..In addition, expression of H. virescens cadherin-like protein affects cell-cell contact and cell membrane integrity when the cells are exposed to activated Cry1Ab/Cry1Ac. ..
- Urdal D, Price V, Sassenfeld H, Cosman D, Gillis S, Park L. Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3. Ann N Y Acad Sci. 1989;554:167-76 pubmed
- Perry R, Balbo P, Jones H, Fetherston J, DeMoll E. Yersiniabactin from Yersinia pestis: biochemical characterization of the siderophore and its role in iron transport and regulation. Microbiology. 1999;145 ( Pt 5):1181-90 pubmed..In contrast to Y. pestis, in which a psn mutation does not repress synthesis of Ybt siderophore or expression of the iron-regulated HMWP1 and HMWP2 proteins, the same mutation in Y. pseudotuberculosis partially repressed these products. ..
- McNally A, Anderson J. Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum. Exp Mol Pathol. 2005;79:126-35 pubmed..These data demonstrate for the first time that the mechanism of macrophage fusion leading to formation of multinucleated giant cells exhibits multiple features of phagocytosis with potential participation of the ER. ..
- Smith S, Huang W, Chancy C, Ganapathy V. Regulation of the reduced-folate transporter by nitric oxide in cultured human retinal pigment epithelial cells. Biochem Biophys Res Commun. 1999;257:279-83 pubmed..These studies suggest that NO produced during retinal disease may affect the function of RFT in adjacent RPE cells. ..
- Nickoloff B, Qin J, Chaturvedi V, Denning M, Bonish B, Miele L. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002;9:842-55 pubmed..These results indicate that activation of Notch signaling is necessary for maturation of human epidermis, and activation by a soluble Notch ligand is sufficient to trigger complete KC differentiation including cornification. ..
- Cancel J, Larsen P. Loss-of-function mutations in the ethylene receptor ETR1 cause enhanced sensitivity and exaggerated response to ethylene in Arabidopsis. Plant Physiol. 2002;129:1557-67 pubmed
- Liu H, Carrington M, Wang C, Holte S, Lee J, Greene B, et al. Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility. J Infect Dis. 2006;193:698-702 pubmed..5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals; P=.0291). These findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1. ..
- Gipp J, Gu G, Crylen C, Kasper S, Bushman W. Hedgehog pathway activity in the LADY prostate tumor model. Mol Cancer. 2007;6:19 pubmed..These data suggest that Ihh expression may be a feature of a progenitor cell population that is involved in tumor development. ..
- Zhang F, McLellan J, Ayala A, Leahy D, Linhardt R. Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway. Biochemistry. 2007;46:3933-41 pubmed..This study clearly demonstrates Shh and Ihog are heparin and HS binding proteins and that both molecules preferentially bind heparin or HS having a high level of sulfation. ..
- Kevany B, Tieman D, Taylor M, Cin V, Klee H. Ethylene receptor degradation controls the timing of ripening in tomato fruit. Plant J. 2007;51:458-67 pubmed..The results are consistent with a model in which receptor levels modulate timing of the onset of fruit ripening by measuring cumulative ethylene exposure. ..
- Ehrenman K, St John T. The erythropoietin receptor gene: cloning and identification of multiple transcripts in an erythroid cell line OCIM1. Exp Hematol. 1991;19:973-7 pubmed..There is an 80% overall homology between the human and murine erythropoietin receptor sequences. ..
- Hla T, Lee M, Ancellin N, Liu C, Thangada S, Thompson B, et al. Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger?. Biochem Pharmacol. 1999;58:201-7 pubmed..Better knowledge of the molecular basis of SPP action is needed to assess the physiological and pathophysiological significance of this bioactive lipid mediator. ..
- Dessus Babus S, Darville T, Cuozzo F, Ferguson K, Wyrick P. Differences in innate immune responses (in vitro) to HeLa cells infected with nondisseminating serovar E and disseminating serovar L2 of Chlamydia trachomatis. Infect Immun. 2002;70:3234-48 pubmed
- Spicer L, Sudo S, Aad P, Wang L, Chun S, Ben Shlomo I, et al. The hedgehog-patched signaling pathway and function in the mammalian ovary: a novel role for hedgehog proteins in stimulating proliferation and steroidogenesis of theca cells. Reproduction. 2009;138:329-39 pubmed publisher..This study illustrates for the first time Hh activation of Gli1 transcriptional factor in theca cells and its stimulation of theca cell proliferation and androgen biosynthesis...
- Chen Y, Riese M, Killinger M, Hoffmann F. A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A. Development. 1998;125:1759-68 pubmed..We propose that 60A activity is required to maintain optimal signaling capacity of the dpp pathway, possibly by forming biologically active heterodimers with Dpp proteins. ..
- Sautin Y, Crawford J, Svetlov S. Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line. Am J Physiol Cell Physiol. 2001;281:C2010-9 pubmed..Cell protection by LPA involves activation of the mitogen-activated protein kinase Erk1/Erk2 cascade and PI 3-kinase-dependent phosphorylation of Akt. ..
- Boehmer E, Goral J, Faunce D, Kovacs E. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol. 2004;75:342-9 pubmed..These observations suggest that decreased MAPK expression could be a mechanism responsible for age-related deterioration of the immune system. ..
- Cook E, Stahl J, Esnault S, Barney N, Graziano F. Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for Staphylococcus aureus involvement in chronic ocular proinflammatory responses. Ann Allergy Asthma Immunol. 2005;94:486-97 pubmed..Conjunctival epithelial cells express TLR-2 and may play an active role in the chronic ocular inflammatory response to S aureus through pathways that involve TLR-2 and PAFR. ..
- Gordon S, Chickarmane V, Ohno C, Meyerowitz E. Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem. Proc Natl Acad Sci U S A. 2009;106:16529-34 pubmed publisher..Our results also may explain how increasing cytokinin concentration leads to the first steps in reestablishing the shoot stem cell niche in vitro. ..
- Boye S, Boye S, Pang J, Ryals R, Everhart D, Umino Y, et al. Functional and behavioral restoration of vision by gene therapy in the guanylate cyclase-1 (GC1) knockout mouse. PLoS ONE. 2010;5:e11306 pubmed publisher..Importantly, results were obtained using a well characterized, clinically relevant AAV vector. These results lay the ground work for the development of an AAV-based gene therapy vector for the treatment of LCA1. ..
- Chang C, Kwok S, Bleecker A, Meyerowitz E. Arabidopsis ethylene-response gene ETR1: similarity of product to two-component regulators. Science. 1993;262:539-44 pubmed..The dominant etr1-1 mutant gene conferred ethylene insensitivity to wild-type Arabidopsis plants when introduced by transformation. ..
- Erickson J, Wu J, Goddard J, Tigyi G, Kawanishi K, Tomei L, et al. Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid. J Biol Chem. 1998;273:1506-10 pubmed..These results indicate that Edg-2 encodes a highly specific LPA receptor. ..
- Ranganathan S, Knaak C, Morales C, Argraves W. Identification of low density lipoprotein receptor-related protein-2/megalin as an endocytic receptor for seminal vesicle secretory protein II. J Biol Chem. 1999;274:5557-63 pubmed..The results indicate that LRP-2 binds SVS-II and can mediate its endocytosis leading to lysosomal degradation. ..
- Brickman T, Armstrong S. Essential role of the iron-regulated outer membrane receptor FauA in alcaligin siderophore-mediated iron uptake in Bordetella species. J Bacteriol. 1999;181:5958-66 pubmed..FauA is a 79-kDa iron-regulated outer membrane receptor protein required for transport and utilization of ferric alcaligin siderophore complexes by Bordetella species...
- Gurevich E, Benovic J, Gurevich V. Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Neuroscience. 2002;109:421-36 pubmed..Thus, the response of receptors to specific drugs stimulating or blocking these receptors may depend on complement of arrestins in their target cells. ..
- Ziady A, Kelley T, Milliken E, Ferkol T, Davis P. Functional evidence of CFTR gene transfer in nasal epithelium of cystic fibrosis mice in vivo following luminal application of DNA complexes targeted to the serpin-enzyme complex receptor. Mol Ther. 2002;5:413-9 pubmed..Molecular conjugates targeting the serpin-enzyme complex receptor, used to compact plasmid DNA, hold promise for gene therapy of cystic fibrosis. ..
- Liedtke C, Yun C, Kyle N, Wang D. Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor. J Biol Chem. 2002;277:22925-33 pubmed..The results indicate the RACK1 binds PKC epsilon and NHERF1, thus serving as a scaffold protein to anchor the enzyme in proximity to CFTR. ..
- Mann P, Kennett M, Harvill E. Toll-like receptor 4 is critical to innate host defense in a murine model of bordetellosis. J Infect Dis. 2004;189:833-6 pubmed..TLR4-deficient mice rapidly succumb following inoculation with as few as 1000 organisms, indicating that TLR4 is critical to innate host defense against bordetellosis...
- Drake C, Fleming P, LaRue A, Barth J, Chintalapudi M, Argraves W. Differential distribution of cubilin and megalin expression in the mouse embryo. Anat Rec A Discov Mol Cell Evol Biol. 2004;277:163-70 pubmed..Furthermore, the finding of megalin expression in blood island endothelial cells and cubilin expression in embryonic endoderm highlight potential new developmental roles for these proteins. ..
- Curry H, Alvarez G, Zwilling B, Lafuse W. Toll-like receptor 2 stimulation decreases IFN-gamma receptor expression in mouse RAW264.7 macrophages. J Interferon Cytokine Res. 2004;24:699-710 pubmed..7 cells. However, at low suboptimal doses of IFN-gamma, Stat1 activation was decreased in TLR2-stimulated cells. ..
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