Experts and Doctors on cell surface receptors in United States


Locale: United States
Topic: cell surface receptors

Top Publications

  1. Rosdahl J, Mourton T, Brady Kalnay S. Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. Mol Cell Neurosci. 2002;19:292-306 pubmed
    ..These results suggest that PTPmu signaling via RACK1 requires PKCdelta activity to promote neurite outgrowth. ..
  2. Gudz T, Schneider T, Haas T, Macklin W. Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes. J Neurosci. 2002;22:7398-407 pubmed
    ..These data establish a novel function for PLP as a part of the integrin signaling complex in oligodendrocytes and suggest that neurotransmitter-mediated integrin receptor signaling may be involved in myelinogenesis. ..
  3. Wong E, Tarazi F, Shahid M. The effectiveness of multi-target agents in schizophrenia and mood disorders: Relevance of receptor signature to clinical action. Pharmacol Ther. 2010;126:173-85 pubmed publisher
  4. Vielmetter J, Kayyem J, Roman J, Dreyer W. Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. J Cell Biol. 1994;127:2009-20 pubmed
    ..Since neogenin is expressed on growing neurites and downregulated at termination of neurite growth, it may also play an important role in many of the complex functional aspects of neurite extension and intercellular signaling. ..
  5. Bocchetta M, Miele L, Pass H, Carbone M. Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells. Oncogene. 2003;22:81-9 pubmed
    ..Our finding is relevant to the process of SV40-mediated human cell transformation, an effect that cannot be accounted for solely by SV40-Tag inhibition of Rb and p53. ..
  6. Cox E, Bennin D, Doan A, O TOOLE T, Huttenlocher A. RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site. Mol Biol Cell. 2003;14:658-69 pubmed
    ..Together, these findings suggest that RACK1 regulates adhesion, protrusion, and chemotactic migration through its interaction with Src. ..
  7. Sarkar S, Peters K, Elco C, Sakamoto S, Pal S, Sen G. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol. 2004;11:1060-7 pubmed
    ..Thus, the PI3K-Akt pathway plays an essential role in TLR3-mediated gene induction. ..
  8. Wayner E, Carter W, Piotrowicz R, Kunicki T. The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platele. J Cell Biol. 1988;107:1881-91 pubmed
    ..These results show that multiple ECMRs function in combination to mediate cell adhesion to complex EMC templates and predicts that variation in ECM composition and ECMR expression may direct cell localization to specific tissue domains. ..
  9. Naik U, Eckfeld K. Junctional adhesion molecule 1 (JAM-1). J Biol Regul Homeost Agents. 2003;17:341-7 pubmed
    ..Further study of the mechanism of JAM-1 action within these diverse systems may demonstrate that JAM-1 is a key player in many different cellular functions. ..

More Information

Publications140 found, 100 shown here

  1. Pritchard J, Olson J. Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas. Cancer Genet Cytogenet. 2008;180:47-50 pubmed
    ..Future directions include examination of distal regions of the PTCHlb promoter as well as alternative exon variants, most notably the CpG island containing PTCH1-1C promoter. ..
  2. Navaratnarajah C, Vongpunsawad S, Oezguen N, Stehle T, Braun W, Hashiguchi T, et al. Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150). J Biol Chem. 2008;283:11763-71 pubmed publisher
    ..Our study sets a structure-based stage for understanding how the SLAM-elicited conformational changes travel through the H-protein ectodomain before triggering fusion protein unfolding and membrane fusion. ..
  3. Li J, Li G, Weis R. The serine chemoreceptor from Escherichia coli is methylated through an inter-dimer process. Biochemistry. 1997;36:11851-7 pubmed
    ..These results demonstrate a role for inter-dimer interactions in transmembrane signaling. ..
  4. Ma Q, Chen Z, del Barco Barrantes I, de la Pompa J, Anderson D. neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron. 1998;20:469-82 pubmed
    ..1996), these data and those of Fode et al. (1998 [this issue of Neuron]) identify ngns as vertebrate neuronal determination genes, analogous to myoD and myf5 in myogenesis. ..
  5. Krebs L, Arnold A. Molecular basis of hyperparathyroidism and potential targets for drug development. Curr Drug Targets Immune Endocr Metabol Disord. 2002;2:167-79 pubmed
    ..Attempts to identify new therapies based specifically on the defective pathways in HPT could complement or eventually supplant traditional approaches. ..
  6. Nguyen L, Bradfield C. The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol. 2008;21:102-16 pubmed
    ..In light of the essential function of the AHR in embryonic development, we discuss the candidacy of each of these compounds as physiologically important activators. ..
  7. You T, Lee M, Jenkins J, Alzate O, Dean D. Blocking binding of Bacillus thuringiensis Cry1Aa to Bombyx mori cadherin receptor results in only a minor reduction of toxicity. BMC Biochem. 2008;9:3 pubmed publisher
    ..The results identify a novel receptor-binding epitope and demonstrate that virtual elimination of binding to cadherin BR-175 does not completely remove toxicity in the case of B. mori. ..
  8. Klueg K, Parody T, Muskavitch M. Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development. Mol Biol Cell. 1998;9:1709-23 pubmed
    ..Cell culture experiments imply that full-length Delta is taken up by Notch-expressing cells. We present evidence that suggests this uptake occurs by a nonphagocytic mechanism. ..
  9. Stein T, Anders N, DeCarli C, Chan S, Mattson M, Johnson J. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. J Neurosci. 2004;24:7707-17 pubmed
    ..Therefore, the elevated expression of transthyretin is mediated by sAPPalpha and protects APP(Sw) mice from developing many of the neuropathologies observed in AD. ..
  10. Gondi C, Dinh D, Gujrati M, Rao J. Simultaneous downregulation of uPAR and MMP-9 induces overexpression of the FADD-associated protein RIP and activates caspase 9-mediated apoptosis in gliomas. Int J Oncol. 2008;33:783-90 pubmed
    ..Based on our results we conclude that the simultaneous downregulation of uPAR and MMP-9 induces apoptosome-mediated apoptosis. ..
  11. Xu T, Wen M, Nagawa S, Fu Y, Chen J, Wu M, et al. Cell surface- and rho GTPase-based auxin signaling controls cellular interdigitation in Arabidopsis. Cell. 2010;143:99-110 pubmed publisher
    ..These findings reveal Rho GTPase-based auxin-signaling mechanisms, which modulate the spatial coordination of cell expansion across a field of cells. ..
  12. Lashbrook C, Tieman D, Klee H. Differential regulation of the tomato ETR gene family throughout plant development. Plant J. 1998;15:243-52 pubmed
    ..Furthermore, the abundance of mRNAs for all three LeETR genes remained uniform in multiple plant tissues experiencing marked changes in ethylene sensitivity, including the cell separation layer throughout tomato flower abscission. ..
  13. Taghon T, David E, Zuniga Pflucker J, Rothenberg E. Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. Genes Dev. 2005;19:965-78 pubmed
  14. Aimanova K, Zhuang M, Gill S. Expression of Cry1Ac cadherin receptors in insect midgut and cell lines. J Invertebr Pathol. 2006;92:178-87 pubmed
    ..In addition, expression of H. virescens cadherin-like protein affects cell-cell contact and cell membrane integrity when the cells are exposed to activated Cry1Ab/Cry1Ac. ..
  15. Urdal D, Price V, Sassenfeld H, Cosman D, Gillis S, Park L. Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3. Ann N Y Acad Sci. 1989;554:167-76 pubmed
  16. Perry R, Balbo P, Jones H, Fetherston J, DeMoll E. Yersiniabactin from Yersinia pestis: biochemical characterization of the siderophore and its role in iron transport and regulation. Microbiology. 1999;145 ( Pt 5):1181-90 pubmed
    ..In contrast to Y. pestis, in which a psn mutation does not repress synthesis of Ybt siderophore or expression of the iron-regulated HMWP1 and HMWP2 proteins, the same mutation in Y. pseudotuberculosis partially repressed these products. ..
  17. McNally A, Anderson J. Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum. Exp Mol Pathol. 2005;79:126-35 pubmed
    ..These data demonstrate for the first time that the mechanism of macrophage fusion leading to formation of multinucleated giant cells exhibits multiple features of phagocytosis with potential participation of the ER. ..
  18. Smith S, Huang W, Chancy C, Ganapathy V. Regulation of the reduced-folate transporter by nitric oxide in cultured human retinal pigment epithelial cells. Biochem Biophys Res Commun. 1999;257:279-83 pubmed
    ..These studies suggest that NO produced during retinal disease may affect the function of RFT in adjacent RPE cells. ..
  19. Nickoloff B, Qin J, Chaturvedi V, Denning M, Bonish B, Miele L. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002;9:842-55 pubmed
    ..These results indicate that activation of Notch signaling is necessary for maturation of human epidermis, and activation by a soluble Notch ligand is sufficient to trigger complete KC differentiation including cornification. ..
  20. Cancel J, Larsen P. Loss-of-function mutations in the ethylene receptor ETR1 cause enhanced sensitivity and exaggerated response to ethylene in Arabidopsis. Plant Physiol. 2002;129:1557-67 pubmed
  21. Liu H, Carrington M, Wang C, Holte S, Lee J, Greene B, et al. Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility. J Infect Dis. 2006;193:698-702 pubmed
    ..5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals; P=.0291). These findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1. ..
  22. Gipp J, Gu G, Crylen C, Kasper S, Bushman W. Hedgehog pathway activity in the LADY prostate tumor model. Mol Cancer. 2007;6:19 pubmed
    ..These data suggest that Ihh expression may be a feature of a progenitor cell population that is involved in tumor development. ..
  23. Zhang F, McLellan J, Ayala A, Leahy D, Linhardt R. Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway. Biochemistry. 2007;46:3933-41 pubmed
    ..This study clearly demonstrates Shh and Ihog are heparin and HS binding proteins and that both molecules preferentially bind heparin or HS having a high level of sulfation. ..
  24. Kevany B, Tieman D, Taylor M, Cin V, Klee H. Ethylene receptor degradation controls the timing of ripening in tomato fruit. Plant J. 2007;51:458-67 pubmed
    ..The results are consistent with a model in which receptor levels modulate timing of the onset of fruit ripening by measuring cumulative ethylene exposure. ..
  25. Ehrenman K, St John T. The erythropoietin receptor gene: cloning and identification of multiple transcripts in an erythroid cell line OCIM1. Exp Hematol. 1991;19:973-7 pubmed
    ..There is an 80% overall homology between the human and murine erythropoietin receptor sequences. ..
  26. Hla T, Lee M, Ancellin N, Liu C, Thangada S, Thompson B, et al. Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger?. Biochem Pharmacol. 1999;58:201-7 pubmed
    ..Better knowledge of the molecular basis of SPP action is needed to assess the physiological and pathophysiological significance of this bioactive lipid mediator. ..
  27. Dessus Babus S, Darville T, Cuozzo F, Ferguson K, Wyrick P. Differences in innate immune responses (in vitro) to HeLa cells infected with nondisseminating serovar E and disseminating serovar L2 of Chlamydia trachomatis. Infect Immun. 2002;70:3234-48 pubmed
  28. Spicer L, Sudo S, Aad P, Wang L, Chun S, Ben Shlomo I, et al. The hedgehog-patched signaling pathway and function in the mammalian ovary: a novel role for hedgehog proteins in stimulating proliferation and steroidogenesis of theca cells. Reproduction. 2009;138:329-39 pubmed publisher
    ..This study illustrates for the first time Hh activation of Gli1 transcriptional factor in theca cells and its stimulation of theca cell proliferation and androgen biosynthesis...
  29. Chen Y, Riese M, Killinger M, Hoffmann F. A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A. Development. 1998;125:1759-68 pubmed
    ..We propose that 60A activity is required to maintain optimal signaling capacity of the dpp pathway, possibly by forming biologically active heterodimers with Dpp proteins. ..
  30. Sautin Y, Crawford J, Svetlov S. Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line. Am J Physiol Cell Physiol. 2001;281:C2010-9 pubmed
    ..Cell protection by LPA involves activation of the mitogen-activated protein kinase Erk1/Erk2 cascade and PI 3-kinase-dependent phosphorylation of Akt. ..
  31. Boehmer E, Goral J, Faunce D, Kovacs E. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol. 2004;75:342-9 pubmed
    ..These observations suggest that decreased MAPK expression could be a mechanism responsible for age-related deterioration of the immune system. ..
  32. Cook E, Stahl J, Esnault S, Barney N, Graziano F. Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for Staphylococcus aureus involvement in chronic ocular proinflammatory responses. Ann Allergy Asthma Immunol. 2005;94:486-97 pubmed
    ..Conjunctival epithelial cells express TLR-2 and may play an active role in the chronic ocular inflammatory response to S aureus through pathways that involve TLR-2 and PAFR. ..
  33. Gordon S, Chickarmane V, Ohno C, Meyerowitz E. Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem. Proc Natl Acad Sci U S A. 2009;106:16529-34 pubmed publisher
    ..Our results also may explain how increasing cytokinin concentration leads to the first steps in reestablishing the shoot stem cell niche in vitro. ..
  34. Boye S, Boye S, Pang J, Ryals R, Everhart D, Umino Y, et al. Functional and behavioral restoration of vision by gene therapy in the guanylate cyclase-1 (GC1) knockout mouse. PLoS ONE. 2010;5:e11306 pubmed publisher
    ..Importantly, results were obtained using a well characterized, clinically relevant AAV vector. These results lay the ground work for the development of an AAV-based gene therapy vector for the treatment of LCA1. ..
  35. Chang C, Kwok S, Bleecker A, Meyerowitz E. Arabidopsis ethylene-response gene ETR1: similarity of product to two-component regulators. Science. 1993;262:539-44 pubmed
    ..The dominant etr1-1 mutant gene conferred ethylene insensitivity to wild-type Arabidopsis plants when introduced by transformation. ..
  36. Erickson J, Wu J, Goddard J, Tigyi G, Kawanishi K, Tomei L, et al. Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid. J Biol Chem. 1998;273:1506-10 pubmed
    ..These results indicate that Edg-2 encodes a highly specific LPA receptor. ..
  37. Ranganathan S, Knaak C, Morales C, Argraves W. Identification of low density lipoprotein receptor-related protein-2/megalin as an endocytic receptor for seminal vesicle secretory protein II. J Biol Chem. 1999;274:5557-63 pubmed
    ..The results indicate that LRP-2 binds SVS-II and can mediate its endocytosis leading to lysosomal degradation. ..
  38. Brickman T, Armstrong S. Essential role of the iron-regulated outer membrane receptor FauA in alcaligin siderophore-mediated iron uptake in Bordetella species. J Bacteriol. 1999;181:5958-66 pubmed
    ..FauA is a 79-kDa iron-regulated outer membrane receptor protein required for transport and utilization of ferric alcaligin siderophore complexes by Bordetella species...
  39. Gurevich E, Benovic J, Gurevich V. Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Neuroscience. 2002;109:421-36 pubmed
    ..Thus, the response of receptors to specific drugs stimulating or blocking these receptors may depend on complement of arrestins in their target cells. ..
  40. Ziady A, Kelley T, Milliken E, Ferkol T, Davis P. Functional evidence of CFTR gene transfer in nasal epithelium of cystic fibrosis mice in vivo following luminal application of DNA complexes targeted to the serpin-enzyme complex receptor. Mol Ther. 2002;5:413-9 pubmed
    ..Molecular conjugates targeting the serpin-enzyme complex receptor, used to compact plasmid DNA, hold promise for gene therapy of cystic fibrosis. ..
  41. Liedtke C, Yun C, Kyle N, Wang D. Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor. J Biol Chem. 2002;277:22925-33 pubmed
    ..The results indicate the RACK1 binds PKC epsilon and NHERF1, thus serving as a scaffold protein to anchor the enzyme in proximity to CFTR. ..
  42. Mann P, Kennett M, Harvill E. Toll-like receptor 4 is critical to innate host defense in a murine model of bordetellosis. J Infect Dis. 2004;189:833-6 pubmed
    ..TLR4-deficient mice rapidly succumb following inoculation with as few as 1000 organisms, indicating that TLR4 is critical to innate host defense against bordetellosis...
  43. Drake C, Fleming P, LaRue A, Barth J, Chintalapudi M, Argraves W. Differential distribution of cubilin and megalin expression in the mouse embryo. Anat Rec A Discov Mol Cell Evol Biol. 2004;277:163-70 pubmed
    ..Furthermore, the finding of megalin expression in blood island endothelial cells and cubilin expression in embryonic endoderm highlight potential new developmental roles for these proteins. ..
  44. Curry H, Alvarez G, Zwilling B, Lafuse W. Toll-like receptor 2 stimulation decreases IFN-gamma receptor expression in mouse RAW264.7 macrophages. J Interferon Cytokine Res. 2004;24:699-710 pubmed
    ..7 cells. However, at low suboptimal doses of IFN-gamma, Stat1 activation was decreased in TLR2-stimulated cells. ..
  45. Tefferi A, Lasho T, Schwager S, Strand J, Elliott M, Mesa R, et al. The clinical phenotype of wild-type, heterozygous, and homozygous JAK2V617F in polycythemia vera. Cancer. 2006;106:631-5 pubmed
  46. Clee S, Yandell B, Schueler K, Rabaglia M, Richards O, Raines S, et al. Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Nat Genet. 2006;38:688-93 pubmed
    ..Our identification of the Sorcs1 gene provides insight into the pathway underlying the pathophysiology of obesity-induced type 2 diabetes mellitus. ..
  47. Nalabothula N, Lakka S, Dinh D, Gujrati M, Olivero W, Rao J. Sense p16 and antisense uPAR bicistronic construct inhibits angiogenesis and induces glioma cell death. Int J Oncol. 2007;30:669-78 pubmed
  48. Wang Z, Berson J, Zhang T, Cen Y, Sun Y, Sharron M, et al. CXCR4 sequences involved in coreceptor determination of human immunodeficiency virus type-1 tropism. Unmasking of activity with M-tropic Env glycoproteins. J Biol Chem. 1998;273:15007-15 pubmed
  49. Ni S, Stephenson S, Lee R. Folate receptor targeted delivery of liposomal daunorubicin into tumor cells. Anticancer Res. 2002;22:2131-5 pubmed
    ..FR-mediated delivery of liposomal DNR to FR-expressing cells increases DNR cellular uptake and cytotoxicity. Therefore, therapeutic evaluation in relevant animal models is warranted. ..
  50. Benson H, Boncompagni E, Guerinot M. An iron uptake operon required for proper nodule development in the Bradyrhizobium japonicum-soybean symbiosis. Mol Plant Microbe Interact. 2005;18:950-9 pubmed
    ..As ferrichrome is a fungal siderophore not likely to be available in nodules, the symbiotic defect suggests that the fegAB operon is serving a different function in planta, possibly one involved in signaling between the two partners. ..
  51. Wright A, Fox A, Johnson K, Zinn K. Systematic screening of Drosophila deficiency mutations for embryonic phenotypes and orphan receptor ligands. PLoS ONE. 2010;5:e12288 pubmed publisher
    ..In the future, these deficiency kits will allow Drosophila researchers to rapidly and efficiently execute genome-wide anatomical screens that require examination of individual embryos at high magnification. ..
  52. Lee M, Thangada S, Paik J, Sapkota G, Ancellin N, Chae S, et al. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Mol Cell. 2001;8:693-704 pubmed
    ..Transactivation of GPCRs by Akt may constitute a specificity switch to integrate rapid G protein-dependent signals into long-term cellular phenomena such as cell migration. ..
  53. Kuo C, Puolakkainen M, Lin T, Witte M, Campbell L. Mannose-receptor positive and negative mouse macrophages differ in their susceptibility to infection by Chlamydia species. Microb Pathog. 2002;32:43-8 pubmed
    ..Further studies using this system may provide insight into the role of mannose-receptor in attachment, entry and survival of chlamydiae in macrophages. ..
  54. Gondi C, Kandhukuri N, Dinh D, Gujrati M, Rao J. Down-regulation of uPAR and uPA activates caspase-mediated apoptosis and inhibits the PI3K/AKT pathway. Int J Oncol. 2007;31:19-27 pubmed
    ..Our studies provide evidence for the presence of a feedback response of the uPAR-uPA system indicative of the multifaceted role of uPAR, and also the therapeutic potential of simultaneously targeting uPAR and uPA in cancer patients. ..
  55. Chernousov M, Kaufman S, Stahl R, Rothblum K, Carey D. Alpha7beta1 integrin is a receptor for laminin-2 on Schwann cells. Glia. 2007;55:1134-44 pubmed
    ..These findings strongly suggest that alpha7beta1 integrin is a Schwann cell receptor for laminin-2 that provides transmembrane linkage between the Schwann cell basal lamina and cytoskeleton. ..
  56. Chivatakarn O, Kaneko S, He Z, Tessier Lavigne M, Giger R. The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors. J Neurosci. 2007;27:7117-24 pubmed
    ..We also conclude that chronic axon growth inhibition by myelin is mediated by NgR1-independent mechanisms. ..
  57. Thomson D, Loneragan G, Thornton A, Lechtenberg K, Emery D, Burkhardt D, et al. Use of a siderophore receptor and porin proteins-based vaccine to control the burden of Escherichia coli O157:H7 in feedlot cattle. Foodborne Pathog Dis. 2009;6:871-7 pubmed publisher
    ..01). Cattle performance was not affected by SRP administration. The E. coli O157:H7 SRP-based vaccine might serve as a preharvest intervention to reduce the burden of E. coli O157:H7 on cattle presented for harvest. ..
  58. Hock B, Lattal K, Kulnane L, Abel T, Lamb B. Pathology associated memory deficits in Swedish mutant genome-based amyloid precursor protein transgenic mice. Curr Aging Sci. 2009;2:205-13 pubmed
    ..40 mice, and these deficits correlated with the presence of Abeta deposits. Our results demonstrate unique behavioral alterations in the R1.40 mouse model of AD that are likely both dependent and independent of Abeta deposition. ..
  59. Penton A, Chen Y, Staehling Hampton K, Wrana J, Attisano L, Szidonya J, et al. Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell. 1994;78:239-50 pubmed
    ..Brk43E is the product of the gene saxophone, which also interacts with dpp. We conclude that dpp signaling in vivo is mediated by at least two receptors, Brk25D and Brk43E. ..
  60. Tieman D, Klee H. Differential expression of two novel members of the tomato ethylene-receptor family. Plant Physiol. 1999;120:165-72 pubmed
    ..Taken together, ethylene perception in tomato is potentially quite complex, with at least five structurally divergent, putative receptor family members exhibiting significant variation in expression levels throughout development. ..
  61. Said H, Chatterjee N, Haq R, Subramanian V, Ortiz A, Matherly L, et al. Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency. Am J Physiol Cell Physiol. 2000;279:C1889-95 pubmed
    ..Furthermore, the upregulation in folate uptake is associated with an increase in mRNA and protein levels of folate carrier, suggesting possible involvement of a transcriptional regulatory mechanism(s) in the upregulation...
  62. Boilard E, Bourgoin S, Bernatchez C, Poubelle P, Surette M. Interaction of low molecular weight group IIA phospholipase A2 with apoptotic human T cells: role of heparan sulfate proteoglycans. FASEB J. 2003;17:1068-80 pubmed
    ..Altogether, these results suggest a role for hIIA PLA2 in the release of arachidonic acid from apoptotic cells through interactions with HSPG and its potential implication in the progression of inflammatory diseases. ..
  63. Jing H, Yen J, Ganea D. A novel signaling pathway mediates the inhibition of CCL3/4 expression by prostaglandin E2. J Biol Chem. 2004;279:55176-86 pubmed
    ..The direct link between CDP and CCL3/4 transcription was established in knock-down experiments using CDP small interference RNA. ..
  64. Sans M, Danese S, de la Motte C, de Souza H, Rivera Reyes B, West G, et al. Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease. Gastroenterology. 2007;132:139-53 pubmed
  65. Tong Y, Hota P, Hamaneh M, Buck M. Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain. Structure. 2008;16:246-58 pubmed publisher
    ..Our study suggests that the oncogenic behavior of the mutants can be rationalized with reference to the structure of the RBD of plexin-B1. ..
  66. Arur S, Uche U, Rezaul K, Fong M, Scranton V, Cowan A, et al. Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Dev Cell. 2003;4:587-98 pubmed
    ..These results provide novel mechanistic insights into how apoptotic cells are removed and may explain a pathogenic mechanism of chronic inflammatory diseases where annexin I autoantibodies have been described. ..
  67. Ralston A, Blair S. Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone. Dev Biol. 2005;280:187-200 pubmed
    ..However, this requirement can be overridden by co-misexpression of the BMP agonist Cv-2, indicating the presence of as yet unknown cues; we discuss possible candidates. ..
  68. Wang L, Anderson D. Identification of an aggression-promoting pheromone and its receptor neurons in Drosophila. Nature. 2010;463:227-31 pubmed publisher
    ..Identification of a pheromone-OSN pair controlling aggression in a genetic organism opens the way to unravelling the neurobiology of this evolutionarily conserved behaviour. ..
  69. Bullesbach E, Schwabe C. The primary structure and the disulfide links of the bovine relaxin-like factor (RLF). Biochemistry. 2002;41:274-81 pubmed
  70. Wyckoff E, Duncan D, Torres A, Mills M, Maase K, Payne S. Structure of the Shigella dysenteriae haem transport locus and its phylogenetic distribution in enteric bacteria. Mol Microbiol. 1998;28:1139-52 pubmed
    ..dysenteriae, indicating that, in these strains, the haem transport locus has an organization similar to that in S. dysenteriae, and it is located in the same relative position on the chromosome...
  71. Ganta R, Wilkerson M, Cheng C, Rokey A, Chapes S. Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes. Infect Immun. 2002;70:380-8 pubmed
    ..Together, these data suggest that macrophage activation and cell-mediated immunity, orchestrated by CD4(+) T cells, are critical for conferring resistance to E. chaffeensis. ..
  72. Xie Y, Hong Y, Ma X, Ren X, Ackerman S, Mei L, et al. DCC-dependent phospholipase C signaling in netrin-1-induced neurite elongation. J Biol Chem. 2006;281:2605-11 pubmed
    ..These results suggest that netrin-1 regulates phosphatidylinositol turnover and demonstrate a crucial role of PLC signaling in netrin-1-induced neurite elongation. ..
  73. Hunt M, Pettis G, McIntosh M. Promoter and operator determinants for fur-mediated iron regulation in the bidirectional fepA-fes control region of the Escherichia coli enterobactin gene system. J Bacteriol. 1994;176:3944-55 pubmed
    ..These observations suggest a mechanism of Fur-mediated regulation in this compact control region that may involve other regulatory components. ..
  74. Ma Q, Kintner C, Anderson D. Identification of neurogenin, a vertebrate neuronal determination gene. Cell. 1996;87:43-52 pubmed
    ..The properties of X-NGNR-1 are thus analogous to those of the Drosophila proneural genes, suggesting that it functions as a vertebrate neuronal determination factor. ..
  75. Comeau M, Johnson R, DuBose R, Petersen M, Gearing P, Vandenbos T, et al. A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. Immunity. 1998;8:473-82 pubmed
    ..These data, then, describe a receptor for an immunologically active semaphorin and suggest that it may serve as a prototype for other plexin-semaphorin binding pairs. ..
  76. Hla T. Sphingosine 1-phosphate receptors. Prostaglandins Other Lipid Mediat. 2001;64:135-42 pubmed
    ..Despite these recent findings, much needs to be clarified with respect to the physiological role of SPP synthesis and action. This review will focus on the recent findings on SPP receptors and the effects on the cardiovascular system. ..
  77. Zhang Z, Merritt E, Ahn M, Roach C, Hou Z, Verlinde C, et al. Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin. J Am Chem Soc. 2002;124:12991-8 pubmed
    ..These results reiterate the power of the structure-based design of multivalent protein ligands as a general strategy for achieving high affinity and potent inhibition...
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