Genomes and Genes
Experts and Doctors on cell surface receptors in United States
Locale: United States
Topic: cell surface receptors
Publications231 found, 100 shown here
- Godwin S, Soltoff S. Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts. Bone. 2002;30:559-66 pubmed
- Park Y, Kim Y, Adams M. Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Proc Natl Acad Sci U S A. 2002;99:11423-8 pubmed..These findings support a theory of coevolution for NMU and Drosophila PRXa peptides and their respective receptors. ..
- VanCompernolle S, Clark K, Rummel K, Todd S. Expression and function of formyl peptide receptors on human fibroblast cells. J Immunol. 2003;171:2050-6 pubmed..This first report of a functional formyl peptide receptor in cells of fibroblast origin opens new possibilities for the role of fibroblasts in innate immune responses. ..
- Stover A, da Silva Correia J, Evans J, Cluff C, Elliott M, Jeffery E, et al. Structure-activity relationship of synthetic toll-like receptor 4 agonists. J Biol Chem. 2004;279:4440-9 pubmed..This novel set of synthetic lipid A mimetics will be useful for Toll-like receptor 4-based investigations and may have clinical utility as stand-alone immunomodulators. ..
- Flo T, Smith K, Sato S, Rodriguez D, Holmes M, Strong R, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 2004;432:917-21 pubmed..Our finding represents a new component of the innate immune system and the acute phase response to infection. ..
- Fan H, Zingarelli B, Peck O, Teti G, Tempel G, Halushka P, et al. Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins. Am J Physiol Cell Physiol. 2005;289:C293-301 pubmed..These data suggest that G(i) proteins differentially regulate murine TLR-mediated inflammatory cytokine production in a cell-specific manner in response to both LPS and gram-positive microbial stimuli. ..
- Getchell T, Kwong K, Saunders C, Stromberg A, Getchell M. Leptin regulates olfactory-mediated behavior in ob/ob mice. Physiol Behav. 2006;87:848-56 pubmed..Our results strongly suggest that leptin acting through leptin receptors modulates olfactory-mediated pre-ingestive behavior. ..
- Dong M, Tepp W, Liu H, Johnson E, Chapman E. Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons. J Cell Biol. 2007;179:1511-22 pubmed..These data suggest that gangliosides are the shared coreceptor for BoNT/A, B, and G, supporting a double-receptor model for these three BoNTs for which the protein receptors are known. ..
- Broytman O, Westmark P, Gurel Z, Malter J. Rck/p54 interacts with APP mRNA as part of a multi-protein complex and enhances APP mRNA and protein expression in neuronal cell lines. Neurobiol Aging. 2009;30:1962-74 pubmed publisher..These findings suggest a novel mechanism for post-transcriptional regulation of APP mRNA. ..
- Horn K, Esposito E, Greene R, Pisano M. The effect of cigarette smoke exposure on developing folate binding protein-2 null mice. Reprod Toxicol. 2008;26:203-9 pubmed publisher..These data confirm an association between sidestream smoke exposure and fetal growth restriction, but do not suggest that loss of Folr2 increased susceptibility to these effects. ..
- Moller T, Contos J, Musante D, Chun J, Ransom B. Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells. J Biol Chem. 2001;276:25946-52 pubmed..Our findings provide evidence for functional LPA receptors on microglia. Thus, LPA might play an important role as a mediator of microglial activation in response to central nervous system injury. ..
- Morton D, Langlais K, Stewart J, Vermehren A. Comparison of the properties of the five soluble guanylyl cyclase subunits in Drosophila melanogaster. J Insect Sci. 2005;5:12 pubmed
- Yang L, Yang H, Rideout K, Cho T, Joo K, Ziegler L, et al. Engineered lentivector targeting of dendritic cells for in vivo immunization. Nat Biotechnol. 2008;26:326-34 pubmed publisher..Thus, lentiviral vectors targeting dendritic cells provide a simple method of producing effective immunity and may provide an alternative route for immunization with protein antigens...
- Gallie D. Regulated ethylene insensitivity through the inducible expression of the Arabidopsis etr1-1 mutant ethylene receptor in tomato. Plant Physiol. 2010;152:1928-39 pubmed publisher..Restoration of ethylene sensitivity was achieved following the cessation of the induction. These results demonstrate the ability to control ethylene responses temporally and in amount through the control of mutant receptor expression. ..
- Schweickart V, Raport C, Godiska R, Byers M, Eddy R, Shows T, et al. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. Genomics. 1994;23:643-50 pubmed..The mouse EBI1 cDNA has also been isolated and encodes a protein with 86% identity to the human homolog. ..
- Desai C, Krueger N, Saito H, Zinn K. Competition and cooperation among receptor tyrosine phosphatases control motoneuron growth cone guidance in Drosophila. Development. 1997;124:1941-52 pubmed..At growth cone choice points along one nerve, two phosphatases cooperate, while along another nerve these same phosphatases can act in opposition to one another. ..
- Wildin R, Cogdell D, Valadez V. AVPR2 variants and V2 vasopressin receptor function in nephrogenic diabetes insipidus. Kidney Int. 1998;54:1909-22 pubmed..This analysis can be aided by examining amino acid sequence variation and conservation among evolutionarily disparate members of the subfamily...
- Fowler T, DeSimone S, Mitton M, Kurjan J, Raper C. Multiple sex pheromones and receptors of a mushroom-producing fungus elicit mating in yeast. Mol Biol Cell. 1999;10:2559-72 pubmed
- Kurt R, Bauck M, Harma S, McCulloch K, Baher A, Urba W. Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo. Cell Immunol. 2001;209:83-8 pubmed..These data confirm that at least one function of lymphotactin includes mediating the recruitment of recently activated antigen-specific T cells. ..
- Bilderback T, Lee F, Auersperg N, Rodland K. Phosphatidylinositol 3-kinase-dependent, MEK- independent proliferation in response to CaR activation. Am J Physiol Cell Physiol. 2002;283:C282-8 pubmed..These results demonstrate that ERK activation cannot account for the full proliferative effect of elevated calcium in OSE cells and suggest the presence of an ERK-independent, PI3K-dependent component in the proliferative response. ..
- Leibovich S, Chen J, Pinhal Enfield G, Belem P, Elson G, Rosania A, et al. Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin. Am J Pathol. 2002;160:2231-44 pubmed
- Mitchell D, Pickens J, Korotkov K, Fan E, Hol W. 3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies. Bioorg Med Chem. 2004;12:907-20 pubmed publisher..Additionally, a consensus binding-pocket for the alkylmorpholine or piperazine moiety present in all of the designed antagonists was established as an important area of the GM1 binding site to target in future work...
- Skoge M, Endres R, Wingreen N. Receptor-receptor coupling in bacterial chemotaxis: evidence for strongly coupled clusters. Biophys J. 2006;90:4317-26 pubmed
- Jiang F, Herman G. Analysis of Nsdhl-deficient embryos reveals a role for Hedgehog signaling in early placental development. Hum Mol Genet. 2006;15:3293-305 pubmed
- Binder B, O Malley R, Wang W, Zutz T, Bleecker A. Ethylene stimulates nutations that are dependent on the ETR1 receptor. Plant Physiol. 2006;142:1690-700 pubmed..Naphthylphthalamic acid eliminated ethylene-stimulated nutations but had no effect on growth inhibition caused by ethylene, pointing to a role for auxin transport in the nutation phenotype. ..
- Xavier K, Miller S, Lu W, Kim J, Rabinowitz J, Pelczer I, et al. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. ACS Chem Biol. 2007;2:128-36 pubmed..This series of chemical events is proposed to enable enteric bacteria to respond to the presence of competitor bacteria by sequestering and destroying AI-2, thereby eliminating the competitors' intercellular communication capabilities. ..
- Cole Tobian J, Michon P, Dabod E, Mueller I, King C. Dynamics of asymptomatic Plasmodium vivax infections and Duffy binding protein polymorphisms in relation to parasitemia levels in Papua New Guinean children. Am J Trop Med Hyg. 2007;77:955-62 pubmed..Thus, common haplotypes are not likely to have arisen from increased fitness as measured by greater parasitemia levels. The restricted number of common haplotypes increases the feasibility of a PvDBPII-based vaccine. ..
- Das R, Burke T, Van Wagoner D, Plow E. L-type calcium channel blockers exert an antiinflammatory effect by suppressing expression of plasminogen receptors on macrophages. Circ Res. 2009;105:167-75 pubmed publisher..These findings demonstrate that Plg-R expression on macrophages is dependent on Ca(v)1.2 LTCC subunit expression. Suppression of Plg-Rs may contribute to the antiinflammatory effects of the widely used LTCC blockers. ..
- Pascal T, Abrol R, Mittal R, Wang Y, Prasadarao N, Goddard W. Experimental validation of the predicted binding site of Escherichia coli K1 outer membrane protein A to human brain microvascular endothelial cells: identification of critical mutations that prevent E. coli meningitis. J Biol Chem. 2010;285:37753-61 pubmed publisher..These studies suggest that inhibition of the interactions of these residues of Loop 1, 2, and 4 with Ecgp96 could provide a therapeutic strategy to prevent neonatal meningitis due to E. coli K1. ..
- Hua J, Chang C, Sun Q, Meyerowitz E. Ethylene insensitivity conferred by Arabidopsis ERS gene. Science. 1995;269:1712-4 pubmed..The altered ERS gene conferred dominant ethylene insensitivity to wild-type Arabidopsis. Double-mutant analysis indicates that ERS acts upstream of the CTR1 protein kinase gene in the ethylene-response pathway. ..
- Farooqui A, Horrocks L. Plasmalogens, phospholipase A2, and docosahexaenoic acid turnover in brain tissue. J Mol Neurosci. 2001;16:263-72; discussion 279-84 pubmed..These abnormalities in the signal-transduction process can be partially corrected by supplementation with a diet enriched with DHA. ..
- Carson D, Lagow E, Thathiah A, Al Shami R, Farach Carson M, Vernon M, et al. Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Mol Hum Reprod. 2002;8:871-9 pubmed..Some of these gene products, e.g. OPN, may play direct roles in embryo-uterine interactions during the implantation process. ..
- O Connor J, Farach Carson M, Schneider C, Carson D. Coculture with prostate cancer cells alters endoglin expression and attenuates transforming growth factor-beta signaling in reactive bone marrow stromal cells. Mol Cancer Res. 2007;5:585-603 pubmed..Collectively, these studies suggest that prostate cancer cells modulate TGF-beta responsiveness of bone marrow stroma as one means of facilitating their own growth in bone...
- Nelson M, Carrano C, Szaniszlo P. Identification of the ferrioxamine B receptor, FoxB, in Escherichia coli K12. Biometals. 1992;5:37-46 pubmed..Both peptides were present in outer membrane preparations of the fhuF mutant H1717, but the 66 kDa peptide was not inducible. These results are evidence for an outer membrane receptor in E. coli unique for linear ferrioxamines...
- Naik U, Naik M, Eckfeld K, Martin DeLeon P, Spychala J. Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody. J Cell Sci. 2001;114:539-47 pubmed..JAM-1 is a single copy gene, which is constitutively expressed on various tissues and cells, and may be involved in cell to cell adhesion through homophilic interaction. ..
- Breuel K, Kougias P, Rice P, Wei D, De Ponti K, Wang J, et al. Anterior pituitary cells express pattern recognition receptors for fungal glucans: implications for neuroendocrine immune involvement in response to fungal infections. Neuroimmunomodulation. 2004;11:1-9 pubmed..In addition, glucan stimulates secretion of prolactin, a hormone that plays an important role in the response to infection. ..
- Stevens P, Lee R. A folate receptor-targeted emulsion formulation for paclitaxel. Anticancer Res. 2003;23:4927-31 pubmed..Furthermore, a novel mechanism for in vivo antitumor activity of nanoparticular formulations, such as these emulsions, that is based on their antiangiogenic effect is proposed. ..
- Uneda S, Toi H, Tsujie T, Tsujie M, Harada N, Tsai H, et al. Anti-endoglin monoclonal antibodies are effective for suppressing metastasis and the primary tumors by targeting tumor vasculature. Int J Cancer. 2009;125:1446-53 pubmed publisher..The findings in the present study are clinically relevant in view of the ongoing clinical trial of a humanized (chimerized) form of SN6j. ..
- Klein R, Jing S, Nanduri V, O ROURKE E, Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell. 1991;65:189-97 pubmed..These results indicate that gp140trk is a functional NGF receptor that mediates at least some of the signal transduction processes initiated by this neurotrophic factor. ..
- Schalinske K, Blemings K, Steffen D, Chen O, Eisenstein R. Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line. Proc Natl Acad Sci U S A. 1997;94:10681-6 pubmed..We conclude that IRP1 is not essential for regulation of ferritin or TfR expression by iron and that IRP2 can act as the sole IRE-dependent mediator of cellular iron homeostasis. ..
- Browning D, Beatty C, Sanstad E, Gunn K, Busby S, Wolfe A. Modulation of CRP-dependent transcription at the Escherichia coli acsP2 promoter by nucleoprotein complexes: anti-activation by the nucleoid proteins FIS and IHF. Mol Microbiol. 2004;51:241-54 pubmed..We propose that FIS and IHF each function directly as anti-activators of CRP, each working independently at different times during growth to set the levels of CRP-dependent acs transcription. ..
- Razonable R, Henault M, Lee L, Laethem C, Johnston P, Watson H, et al. Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2. Antimicrob Agents Chemother. 2005;49:1617-21 pubmed..Hence, TLR2-TLR1 coactivation serves as the underlying mechanism for the proinflammatory toxicities associated with AmB. ..
- Kang P, Azad A, Torrelles J, Kaufman T, Beharka A, Tibesar E, et al. The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J Exp Med. 2005;202:987-99 pubmed..0 +/- 5.1% vs. 38.6 +/- 0.6%). Thus, engagement of the MR by ManLAM during the phagocytic process directs M.tb to its initial phagosomal niche, thereby enhancing survival in human macrophages. ..
- Ariizumi T, Murase K, Sun T, Steber C. Proteolysis-independent downregulation of DELLA repression in Arabidopsis by the gibberellin receptor GIBBERELLIN INSENSITIVE DWARF1. Plant Cell. 2008;20:2447-59 pubmed publisher..Thus, a SLY1-independent mechanism for GA signaling may function without DELLA degradation. ..
- Olwin B, Burrus L, Zuber M, Lueddecke B. Characterization of a non-tyrosine kinase FGF-binding protein. Ann N Y Acad Sci. 1991;638:195-203 pubmed
- Bigas A, Martin D, Milner L. Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. Mol Cell Biol. 1998;18:2324-33 pubmed..These findings suggest that the multiple forms of Notch found in mammals have structural differences that allow their function to be modulated by specific differentiation signals. ..
- Li X, Tupper J, Bannerman D, Winn R, Rhodes C, Harlan J. Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells. Infect Immun. 2003;71:4414-20 pubmed..Further, these studies suggest that PI3-kinase is an important mediator of LPS and IL-1 beta signaling leading to NF-kappa B activation in endothelial cells and that Akt is necessary but not sufficient for NF-kappa B activation by TLR4. ..
- Maxwell J, Rossi R, McSorley S, Vella A. T cell clonal conditioning: a phase occurring early after antigen presentation but before clonal expansion is impacted by Toll-like receptor stimulation. J Immunol. 2004;172:248-59 pubmed..We postulate that this is a stage where T cells are either conditioned to survive or to delete depending upon the activation status of the innate immune system. ..
- Datta S, Novotny M, Li X, Tebo J, Hamilton T. Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA. J Immunol. 2004;173:2755-61 pubmed..Hence the ability of TIRs to signal stabilization of mRNA appears to be linked to the MyD88-dependent signaling pathway. ..
- McCarthy T, Torrelles J, MacFarlane A, Katawczik M, Kutzbach B, DesJardin L, et al. Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophages. Mol Microbiol. 2005;58:774-90 pubmed..We conclude that MtmanB encodes a functional PMM involved in the biosynthesis of mannosylated lipoglycans that participate in the association of mycobacteria with macrophage phagocytic receptors. ..
- Lipinski R, Gipp J, Zhang J, Doles J, Bushman W. Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling. Exp Cell Res. 2006;312:1925-38 pubmed
- Barnakov A, Barnakova L, Hazelbauer G. Comparison in vitro of a high- and a low-abundance chemoreceptor of Escherichia coli: similar kinase activation but different methyl-accepting activities. J Bacteriol. 1998;180:6713-8 pubmed..This addition enhanced the in vitro methyl-accepting activity of Trg 10-fold. ..
- Finkelstein L, Ney P, Liu Q, Paulson R, Correll P. Sf-Stk kinase activity and the Grb2 binding site are required for Epo-independent growth of primary erythroblasts infected with Friend virus. Oncogene. 2002;21:3562-70 pubmed..These data clearly demonstrate a requirement for signaling through Sf-Stk in the Epo-independent expansion of Friend virus-infected cells, and suggest a pivotal role for Grb2 in this response. ..
- Gu J, Johns A, Morser J, Dole W, Greaves D, Deng G. Urokinase plasminogen activator receptor promotes macrophage infiltration into the vascular wall of ApoE deficient mice. J Cell Physiol. 2005;204:73-82 pubmed..7 cells expressing human uPAR. These data demonstrate that uPAR plays a key role in promoting macrophage infiltration into the arterial wall of ApoE(-/-) mice. ..
- Gondi C, Lakka S, Dinh D, Olivero W, Gujrati M, Rao J. Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice. Clin Cancer Res. 2007;13:4051-60 pubmed..In conclusion, the plasmid-expressed RNAi targeting uPAR and uPA via the i.p. route has potential clinical applications for the treatment of glioma. ..
- Elco C, Guenther J, Williams B, Sen G. Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3, NF-kappaB, and interferon but not toll-like receptor 3. J Virol. 2005;79:3920-9 pubmed..Thus, IRF-3 can suppress the expression of NF-kappaB-dependent genes in SeV-infected cells. ..
- Fiedler S, Schillace R, Daniels C, Andrews S, Carr D. Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner. FEBS Lett. 2010;584:873-7 pubmed publisher..Collectively, these data suggest a possible mechanism for the targeting and integration of adenosine 3',5'-cyclic monophosphate (cAMP) and semaphorin signaling in immune cells. ..
- Giniger E. A role for Abl in Notch signaling. Neuron. 1998;20:667-81 pubmed..We therefore speculate that Disabled and Abl may play a role in Notch signaling in Drosophila axons, perhaps by binding to the Notch intracellular domain. ..
- Ciardi J, Tieman D, Jones J, Klee H. Reduced expression of the tomato ethylene receptor gene LeETR4 enhances the hypersensitive response to Xanthomonas campestris pv. vesicatoria. Mol Plant Microbe Interact. 2001;14:487-95 pubmed..Because the ethylene action inhibitor 1-methylcyclopropene alleviates the enhanced HR phenotype in LeETR4 antisense plants, these changes in pathogen response are a result of increased ethylene sensitivity. ..
- Smits P, Dy P, Mitra S, Lefebvre V. Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol. 2004;164:747-58 pubmed..In conclusion, Sox5 and Sox6 are needed for the establishment of multilayered growth plates, and thereby for proper and timely development of endochondral bones. ..
- Dharmasiri N, Dharmasiri S, Weijers D, Lechner E, Yamada M, Hobbie L, et al. Plant development is regulated by a family of auxin receptor F box proteins. Dev Cell. 2005;9:109-19 pubmed..Correspondingly, all TIR1/AFB proteins interact with BDL, and BDL is stabilized in triple mutant plants. Our results indicate that TIR1 and the AFB proteins collectively mediate auxin responses throughout plant development. ..
- Achkar C, Gong Q, Frankfater A, Bajkowski A. Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts. J Biol Chem. 1990;265:13650-4 pubmed
- McAndrew P, Frostholm A, Evans J, Zdilar D, Goldowitz D, Chiu I, et al. Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex. J Comp Neurol. 1998;391:444-55 pubmed..The restricted pattern of FGF-1 and RPTPrho implies that these molecules may have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex. ..
- Handlogten M, Huang C, Shiraishi N, Awata H, Miller R. The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway. J Biol Chem. 2001;276:13941-8 pubmed..These results demonstrate that the CaR activates cPLA(2) via a Galpha(q), PLC, Ca(2+)-CaM, and calmodulin-dependent protein kinase-dependent pathway that is independent the ERK pathway. ..
- Blankenship K, Williams J, Lawrence M, McLeish K, Dean W, Arthur J. The calcium-sensing receptor regulates calcium absorption in MDCK cells by inhibition of PMCA. Am J Physiol Renal Physiol. 2001;280:F815-22 pubmed..In addition, they provide a potential mechanism for the CaR to inhibit calcium transport, inhibition of PMCA. ..
- Jin H, Song Y, Boel G, Kochar J, Pancholi V. Group A streptococcal surface GAPDH, SDH, recognizes uPAR/CD87 as its receptor on the human pharyngeal cell and mediates bacterial adherence to host cells. J Mol Biol. 2005;350:27-41 pubmed..This interaction significantly contributes to bacterial adherence and thus may play a significant role in GAS pathogenesis by regulating intracellular signaling events in pharyngeal cells. ..
- Tong Y, Hota P, Penachioni J, Hamaneh M, Kim S, Alviani R, et al. Structure and function of the intracellular region of the plexin-b1 transmembrane receptor. J Biol Chem. 2009;284:35962-72 pubmed publisher..These findings suggest that the monomeric form of the intracellular region is primed for GAP activity and extend a model for plexin activation. ..
- Kirkpatrick L, Matzuk M, Dodds D, Perin M. Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. J Biol Chem. 2000;275:17786-92 pubmed..These processes are likely to directly effect the localization and function of neuronal pentraxins in neuronal uptake or synapse formation and remodeling. ..
- Van Brocklyn J, Letterle C, Snyder P, Prior T. Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. Cancer Lett. 2002;181:195-204 pubmed..Thus, S1P signaling through EDG receptors may contribute to glioblastoma growth in vivo. ..
- Davy A, Aubin J, Soriano P. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev. 2004;18:572-83 pubmed..Our results demonstrate that ephrin-B1 acts both as a ligand and as a receptor in a tissue-specific manner during embryogenesis. ..
- Coleman J, Semple Rowland S. GC1 deletion prevents light-dependent arrestin translocation in mouse cone photoreceptor cells. Invest Ophthalmol Vis Sci. 2005;46:12-6 pubmed..These results suggest that multiple, independent pathways regulate the translocation of phototransduction proteins and that GC1, and presumably cGMP, are of key importance in signaling the translocation of cone arrestin. ..
- Plager D, Kahl J, Asmann Y, Nilson A, Pallanch J, Friedman O, et al. Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. PLoS ONE. 2010;5:e11450 pubmed publisher..The identified gene expression changes provide additional diagnostic and therapeutic targets for aCRSwNP and other eosinophilic epithelial diseases. ..
- Griswold I, Zhou H, Matison M, Swanson R, McIntosh L, Simon M, et al. The solution structure and interactions of CheW from Thermotoga maritima. Nat Struct Biol. 2002;9:121-5 pubmed publisher..These results provide a structural basis for a model in which CheW acts as a molecular bridge between CheA and the cytoplasmic tails of the receptor...
- Horabin J, Walthall S, Vied C, Moses M. A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch. Development. 2003;130:6101-9 pubmed..These data suggest that the Hh pathway impacts on the sex determination process and vice versa and that the pathway may serve more functions than the regulation of Ci. ..
- Kunnimalaiyaan M, Traeger K, Chen H. Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells. Am J Physiol Gastrointest Liver Physiol. 2005;289:G636-42 pubmed..Therefore, manipulation of the Notch1 signaling pathway may be useful for expanding the targets for therapeutic and palliative treatment of patients with carcinoid tumors. ..
- Scott G, Jacobs S, Pentland A. sPLA2-X stimulates cutaneous melanocyte dendricity and pigmentation through a lysophosphatidylcholine-dependent mechanism. J Invest Dermatol. 2006;126:855-61 pubmed..Because secretory phospholipases are released during inflammation and are regulated by UV irradiation, our data suggest an important role for sPLA2-X in cutaneous pigmentation through the release of LPC. ..
- Morton G, Niswender K, Rhodes C, Myers M, Blevins J, Baskin D, et al. Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology. 2003;144:2016-24 pubmed..Adenoviral gene therapy is thus a viable strategy with which to study the physiological importance of specific molecules acting in discrete brain areas. ..
- Rosdahl J, Mourton T, Brady Kalnay S. Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. Mol Cell Neurosci. 2002;19:292-306 pubmed..These results suggest that PTPmu signaling via RACK1 requires PKCdelta activity to promote neurite outgrowth. ..
- Gudz T, Schneider T, Haas T, Macklin W. Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes. J Neurosci. 2002;22:7398-407 pubmed..These data establish a novel function for PLP as a part of the integrin signaling complex in oligodendrocytes and suggest that neurotransmitter-mediated integrin receptor signaling may be involved in myelinogenesis. ..
- Vielmetter J, Kayyem J, Roman J, Dreyer W. Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. J Cell Biol. 1994;127:2009-20 pubmed..Since neogenin is expressed on growing neurites and downregulated at termination of neurite growth, it may also play an important role in many of the complex functional aspects of neurite extension and intercellular signaling. ..
- Bocchetta M, Miele L, Pass H, Carbone M. Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells. Oncogene. 2003;22:81-9 pubmed..Our finding is relevant to the process of SV40-mediated human cell transformation, an effect that cannot be accounted for solely by SV40-Tag inhibition of Rb and p53. ..
- Cox E, Bennin D, Doan A, O TOOLE T, Huttenlocher A. RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site. Mol Biol Cell. 2003;14:658-69 pubmed..Together, these findings suggest that RACK1 regulates adhesion, protrusion, and chemotactic migration through its interaction with Src. ..
- Sarkar S, Peters K, Elco C, Sakamoto S, Pal S, Sen G. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol. 2004;11:1060-7 pubmed..Thus, the PI3K-Akt pathway plays an essential role in TLR3-mediated gene induction. ..
- Wayner E, Carter W, Piotrowicz R, Kunicki T. The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platele. J Cell Biol. 1988;107:1881-91 pubmed..These results show that multiple ECMRs function in combination to mediate cell adhesion to complex EMC templates and predicts that variation in ECM composition and ECMR expression may direct cell localization to specific tissue domains. ..
- Naik U, Eckfeld K. Junctional adhesion molecule 1 (JAM-1). J Biol Regul Homeost Agents. 2003;17:341-7 pubmed..Further study of the mechanism of JAM-1 action within these diverse systems may demonstrate that JAM-1 is a key player in many different cellular functions. ..
- Pritchard J, Olson J. Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas. Cancer Genet Cytogenet. 2008;180:47-50 pubmed..Future directions include examination of distal regions of the PTCHlb promoter as well as alternative exon variants, most notably the CpG island containing PTCH1-1C promoter. ..