Experts and Doctors on cell proliferation in Austria


Locale: Austria
Topic: cell proliferation

Top Publications

  1. Woldman I, Reither H, Kattinger A, Hornykiewicz O, Pifl C. Dopamine inhibits cell growth and cell cycle by blocking ribonucleotide reductase. Neuropharmacology. 2005;48:525-37 pubmed
    ..This novel molecular mechanism of intracellular DA action independent of plasmamembrane receptors may be involved in processes controlling the development and survival of brain dopaminergic neurons. ..
  2. Schmid W, Zorbas Seifried S, John R, Arion V, Jakupec M, Roller A, et al. The first ruthenium-based paullones: syntheses, X-ray diffraction structures, and spectroscopic and antiproliferative properties in vitro. Inorg Chem. 2007;46:3645-56 pubmed
    ..The novel complexes show an intercalative mode of interaction with DNA, which may render them attractive alternatives to metal compounds with a coordinative mode of interaction. ..
  3. Fiebiger W, Olszewski U, Ulsperger E, Geissler K, Hamilton G. In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines. Clin Transl Oncol. 2011;13:43-9 pubmed publisher
    ..In summary, among the novel platinum drugs satraplatin has the potential for treatment of lung carcinoids and DCA potentiates the cytotoxicity of selected platinum drugs. ..
  4. Siller Matula J, Schwameis M, Blann A, Mannhalter C, Jilma B. Thrombin as a multi-functional enzyme. Focus on in vitro and in vivo effects. Thromb Haemost. 2011;106:1020-33 pubmed publisher
  5. Ruzicka K, Grskovic B, Pavlovic V, Qujeq D, Karimi A, Mueller M. Differentiation of human umbilical cord blood CD133+ stem cells towards myelo-monocytic lineage. Clin Chim Acta. 2004;343:85-92 pubmed
  6. Schneider M, Meingassner J, Lipp M, Moore H, Rot A. CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells. J Exp Med. 2007;204:735-45 pubmed
  7. Gruber T, Fresser F, Jenny M, Uberall F, Leitges M, Baier G. PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes. Mol Immunol. 2008;45:117-26 pubmed
    ..Together, these data demonstrate that atypical PKCzeta/iota isotypes serve as direct downstream targets of PKCtheta in the signalling pathway leading to NF-kappaB activation in T lymphocytes. ..
  8. Kern J, Bauer M, Rychli K, Wojta J, Ritsch A, Gastl G, et al. Alternative splicing of vasohibin-1 generates an inhibitor of endothelial cell proliferation, migration, and capillary tube formation. Arterioscler Thromb Vasc Biol. 2008;28:478-84 pubmed publisher
    ..Our data point out that alternative splicing of the VASH1 pre-mRNA transcript generates a potent antiangiogenic protein. ..
  9. Stepanenko I, Krokhin A, John R, Roller A, Arion V, Jakupec M, et al. Synthesis, structure, spectroscopic properties, and antiproliferative activity in vitro of novel osmium(III) complexes with azole heterocycles. Inorg Chem. 2008;47:7338-47 pubmed publisher

More Information

Publications111 found, 100 shown here

  1. Musteanu M, Blaas L, Mair M, Schlederer M, Bilban M, Tauber S, et al. Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice. Gastroenterology. 2010;138:1003-11.e1-5 pubmed publisher
    ..Our data suggest that Stat3 impairs invasiveness of intestinal tumors. Therefore, therapeutic targeting of the Stat3 signaling pathway in intestinal cancer should be evaluated for adverse effects on tumor progression. ..
  2. Oh S, Erb H, Hobisch A, Santer F, Culig Z. Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways. Endocr Relat Cancer. 2012;19:305-19 pubmed publisher
  3. Dornetshuber Fleiss R, Heffeter P, Mohr T, Hazemi P, Kryeziu K, Seger C, et al. Destruxins: fungal-derived cyclohexadepsipeptides with multifaceted anticancer and antiangiogenic activities. Biochem Pharmacol. 2013;86:361-77 pubmed publisher
    ..Thus, Dtx represent feasible, multifunctional anticancer drug candidates for preclinical development especially against colorectal cancer. ..
  4. Tomek K, Wagner R, Varga F, Singer C, Karlic H, Grunt T. Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer. Mol Cancer Res. 2011;9:1767-79 pubmed publisher
    ..FASN is a promising cancer target, whose inhibition not only abrogates lipogenesis, which is indispensable for cancer growth, but also downregulates oncogenic PI3K signaling. ..
  5. KIMMEL R, Meyer D. Molecular regulation of pancreas development in zebrafish. Methods Cell Biol. 2010;100:261-80 pubmed publisher
  6. Peter B, Cerny Reiterer S, Hadzijusufovic E, Schuch K, Stefanzl G, Eisenwort G, et al. The pan-Bcl-2 blocker obatoclax promotes the expression of Puma, Noxa, and Bim mRNA and induces apoptosis in neoplastic mast cells. J Leukoc Biol. 2014;95:95-104 pubmed publisher
    ..Whether these drug effects can be translated to application in patients with advanced SM remains to be determined. ..
  7. Friedl G, Windhager R, Schmidt H, Aigner R. The osteogenic response of undifferentiated human mesenchymal stem cells (hMSCs) to mechanical strain is inversely related to body mass index of the donor. Acta Orthop. 2009;80:491-8 pubmed publisher
  8. Arion V, Dobrov A, Göschl S, Jakupec M, Keppler B, Rapta P. Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs. Chem Commun (Camb). 2012;48:8559-61 pubmed publisher
    ..A modified paullone ligand bearing a TEMPO free-radical unit (HL) and its ruthenium(II) and osmium(II)-arene complexes [M(p-cymene)(HL)Cl]Cl·nH(2)O (M = Ru, Os) exhibit high antiproliferative activity in human cancer cell lines...
  9. Kothmaier H, Quehenberger F, Halbwedl I, Morbini P, Demirag F, Zeren H, et al. EGFR and PDGFR differentially promote growth in malignant epithelioid mesothelioma of short and long term survivors. Thorax. 2008;63:345-51 pubmed
    ..We have demonstrated that small scale proteomics can be carried out by powerful linkage of TMA, immunohistochemistry and statistical methods to identify proteins which might be relevant targets for therapeutic intervention. ..
  10. Bartel C, Tichy A, Schoenkypl S, Aurich C, Walter I. Effects of steroid hormones on differentiated glandular epithelial and stromal cells in a three dimensional cell culture model of the canine endometrium. BMC Vet Res. 2013;9:86 pubmed publisher
  11. Jantscher F, Pirker C, Mayer C, Berger W, Sutterluety H. Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities. Mol Cancer. 2011;10:28 pubmed publisher
    ..The presented data indicate that deactivation of the tumor suppressor RB is one of the requirements for overriding a cell cycle checkpoint triggered by increased Aurora-A levels. ..
  12. Bergmeister H, Grasl C, Walter I, Plasenzotti R, Stoiber M, Schreiber C, et al. Electrospun small-diameter polyurethane vascular grafts: ingrowth and differentiation of vascular-specific host cells. Artif Organs. 2012;36:54-61 pubmed publisher
    ..Besides biomechanical benefits, electrospun polyurethane grafts exhibit excellent biocompatibility in vivo. Cell immigration and differentiation seems to be promoted by the nanostructured artificial matrix. ..
  13. Zödl B, Schmid D, Wassler G, Gundacker C, Leibetseder V, Thalhammer T, et al. Intestinal transport and metabolism of acrylamide. Toxicology. 2007;232:99-108 pubmed
    ..Depletion of cellular glutathione levels may be one potential mechanism for acrylamide (geno)toxicity. ..
  14. Stöckl P, Zankl C, Hutter E, Unterluggauer H, Laun P, Heeren G, et al. Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells. Free Radic Biol Med. 2007;43:947-58 pubmed
  15. Murias M, Miksits M, Aust S, Spatzenegger M, Thalhammer T, Szekeres T, et al. Metabolism of resveratrol in breast cancer cell lines: impact of sulfotransferase 1A1 expression on cell growth inhibition. Cancer Lett. 2008;261:172-82 pubmed
  16. Luft P, Oostingh G, Gruijthuijsen Y, Horejs Hoeck J, Lehmann I, Duschl A. Patulin influences the expression of Th1/Th2 cytokines by activated peripheral blood mononuclear cells and T cells through depletion of intracellular glutathione. Environ Toxicol. 2008;23:84-95 pubmed publisher
    ..The depletion of intracellular glutathione may influence the balance between Th1 and Th2 cells and have implications for allergic diseases. ..
  17. Niwa S, Graf C, Bornancin F. Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc Res. 2009;77:389-93 pubmed publisher
    ..These observations collectively suggest that CerK-catalyzed formation of C1P may regulate angiogenesis by a novel mechanism that is independent of S1P formation and signaling. ..
  18. Mohr T, Desser L. Plant proteolytic enzyme papain abrogates angiogenic activation of human umbilical vein endothelial cells (HUVEC) in vitro. BMC Complement Altern Med. 2013;13:231 pubmed publisher
    ..These findings indicate that plant proteolytic enzymes may have potential as preventive and therapeutic agents against angiogenesis related human diseases. ..
  19. Tempfer H, Gehwolf R, Lehner C, Wagner A, Mtsariashvili M, Bauer H, et al. Effects of crystalline glucocorticoid triamcinolone acetonide on cultered human supraspinatus tendon cells. Acta Orthop. 2009;80:357-62 pubmed publisher
    ..These results may indicate that the use of TAA is one reason for weaker mechanical tendon properties and for the high rate of re-rupture after supraspinatus tendon repair. ..
  20. Kudela P, Koller V, Lubitz W. Bacterial ghosts (BGs)--advanced antigen and drug delivery system. Vaccine. 2010;28:5760-7 pubmed publisher
  21. Lehner B, Sandner B, Marschallinger J, Lehner C, Furtner T, Couillard Despres S, et al. The dark side of BrdU in neural stem cell biology: detrimental effects on cell cycle, differentiation and survival. Cell Tissue Res. 2011;345:313-28 pubmed publisher
    ..Our results reveal so far uncharacterized effects of BrdU on adult NPCs. We conclude that, because of its ubiquitous use in stem cell biology, any potential effect of BrdU of NPCs has to be scrutinized prior to interpretation of data. ..
  22. Pollheimer J, Loregger T, Sonderegger S, Saleh L, Bauer S, Bilban M, et al. Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast. Am J Pathol. 2006;168:1134-47 pubmed
    ..Thus, canonical Wnt signaling may promote invasive trophoblast differentiation, and exaggerated activation of the path-way could contribute to trophoblastic hyperplasia and local invasion. ..
  23. Schallmoser K, Bartmann C, Rohde E, Bork S, Guelly C, Obenauf A, et al. Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions. Haematologica. 2010;95:867-74 pubmed publisher
    ..In advance of therapeutic application, this panel of genes might offer a feasible approach to assessing mesenchymal stromal cell quality with regard to the state of replicative senescence. ..
  24. Gehrke H, Frühmesser A, Pelka J, Esselen M, Hecht L, Blank H, et al. In vitro toxicity of amorphous silica nanoparticles in human colon carcinoma cells. Nanotoxicology. 2013;7:274-93 pubmed publisher
    ..Additionally, investigations regarding DNA integrity revealed no substantial (oxidative) DNA damage. ..
  25. Drach J, Seidl S, Kaufmann H. Treatment of mantle cell lymphoma: targeting the microenvironment. Expert Rev Anticancer Ther. 2005;5:477-85 pubmed
    ..Thus, with the use of novel therapeutic interventions, it is hoped that clinicians will be able to improve the outcome of patients with mantle cell lymphoma. ..
  26. Messner B, Knoflach M, Seubert A, Ritsch A, Pfaller K, Henderson B, et al. Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance. Arterioscler Thromb Vasc Biol. 2009;29:1392-8 pubmed publisher
    ..Our research suggests Cd has promoting effects on early human and murine atherosclerosis, which were partly offset by high Zn concentrations. ..
  27. Puhr M, Santer F, Neuwirt H, Marcias G, Hobisch A, Culig Z. SOCS-3 antagonises the proliferative and migratory effects of fibroblast growth factor-2 in prostate cancer by inhibition of p44/p42 MAPK signalling. Endocr Relat Cancer. 2010;17:525-38 pubmed publisher
    ..On the basis of the present results, we propose that SOCS-3 is a novel modulator of FGF-2-regulated cellular events in prostate cancer. ..
  28. Taha H, Skrzypek K, Guevara I, Nigisch A, Mustafa S, Grochot Przeczek A, et al. Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants. Arterioscler Thromb Vasc Biol. 2010;30:1634-41 pubmed publisher
    ..The (GT)n promoter polymorphism significantly modulates a cytoprotective, proangiogenic, and antiinflammatory function of HO-1 in human endothelium. ..
  29. Brustmann H. DNA fragmentation factor (DFF45): expression and prognostic value in serous ovarian cancer. Pathol Res Pract. 2006;202:713-20 pubmed
    ..0187). Apoptotic bodies were consistently DFF45-negative. This study indicates that DFF45 expression is frequently upregulated in ovarian serous carcinomas and may serve as a marker of aggressive behavior with prognostic value. ..
  30. Reipert S, Wiche G. High-pressure freezing and low-temperature fixation of cell monolayers grown on sapphire coverslips. Methods Cell Biol. 2008;88:165-80 pubmed publisher
  31. Schulenburg A, Cech P, Herbacek I, Marian B, Wrba F, Valent P, et al. CD44-positive colorectal adenoma cells express the potential stem cell markers musashi antigen (msi1) and ephrin B2 receptor (EphB2). J Pathol. 2007;213:152-60 pubmed
    ..They also express markers typical of colorectal progenitor cells, msi1 and ephB2, in the premalignant progenitor population. ..
  32. Leitner J, Klauser C, Pickl W, Stockl J, Majdic O, Bardet A, et al. B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction. Eur J Immunol. 2009;39:1754-64 pubmed publisher
    ..In these experiments we found no evidence for such an interaction. Furthermore, our data do not point to a role for murine TREML2 as a receptor for murine B7-H3. ..
  33. Stradner M, Hermann J, Angerer H, Setznagl D, Sunk I, Windhager R, et al. Spingosine-1-phosphate stimulates proliferation and counteracts interleukin-1 induced nitric oxide formation in articular chondrocytes. Osteoarthritis Cartilage. 2008;16:305-11 pubmed
    ..These results suggest that S1P provides an anti-catabolic signal in articular chondrocytes. ..
  34. Cebrián Losantos B, Krokhin A, Stepanenko I, Eichinger R, Jakupec M, Arion V, et al. Osmium NAMI-A analogues: synthesis, structural and spectroscopic characterization, and antiproliferative properties. Inorg Chem. 2007;46:5023-33 pubmed
    ..Structure-activity relationships and the potential of the prepared complexes for further development are discussed...
  35. Milunovic M, Enyedy E, Nagy N, Kiss T, Trondl R, Jakupec M, et al. L- and D-proline thiosemicarbazone conjugates: coordination behavior in solution and the effect of copper(II) coordination on their antiproliferative activity. Inorg Chem. 2012;51:9309-21 pubmed publisher
    ..6 and 5.5 ?M for [Cu(L-Pro-STSC)Cl]Cl in CH1 and SW480 cells, respectively. ..
  36. Yotova I, Quan P, Leditznig N, Beer U, Wenzl R, Tschugguel W. Abnormal activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in eutopic endometrial stromal cells of patients with endometriosis. Hum Reprod. 2011;26:885-97 pubmed publisher
    ..The differences in cell proliferation and migration between both cell types are likely due to increased activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in cells from endometriosis patients. ..
  37. Bachmayr Heyda A, Aust S, Heinze G, Polterauer S, Grimm C, Braicu E, et al. Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients--a study of the OVCAD consortium. BMC Cancer. 2013;13:422 pubmed publisher
    ..Moreover, the association of high densities of tumor infiltrating cytotoxic T lymphocytes with a better overall survival was confirmed. ..
  38. Haeubl M, Schuerz S, Svejda B, Reith L, Gruber B, Pfragner R, et al. Asymmetrically substituted cationic indole- and fluorene porphyrins inhibit tumor proliferation in small intestinal neuroendocrine tumors and medullary thyroid carcinomas. Eur J Med Chem. 2010;45:760-73 pubmed publisher
  39. Bennani Baiti I, Machado I, Llombart Bosch A, Kovar H. Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. Hum Pathol. 2012;43:1300-7 pubmed publisher
  40. Pucciarelli D, Lengger N, Takáčová M, Csaderova L, Bartosova M, Breiteneder H, et al. Hypoxia increases the heterogeneity of melanoma cell populations and affects the response to vemurafenib. Mol Med Rep. 2016;13:3281-8 pubmed publisher
    ..These data confirmed that vemurafenib may be successful in treating the proliferating cells, whereas the non‑proliferating subpopulation must be addressed by a combination of vemurafenib with other treatment strategies. ..
  41. Andavan G, Lemmens Gruber R. Cyclodepsipeptides from marine sponges: natural agents for drug research. Mar Drugs. 2010;8:810-34 pubmed publisher
    ..Nonetheless, the actin cytoskeleton remains a potential target for anti-cancer drug development. These features imply the use of cyclodepsipeptides as molecular models in drug research...
  42. Kirchberger S, Majdic O, Steinberger P, Bluml S, Pfistershammer K, Zlabinger G, et al. Human rhinoviruses inhibit the accessory function of dendritic cells by inducing sialoadhesin and B7-H1 expression. J Immunol. 2005;175:1145-52 pubmed
    ..These observations suggest that an altered accessory molecule repertoire on DC upon interaction with HRV down-modulates adaptive immune responses during the viral infection. ..
  43. Colleselli D, Bijuklic K, Mosheimer B, Kähler C. Inhibition of cyclooxygenase (COX)-2 affects endothelial progenitor cell proliferation. Exp Cell Res. 2006;312:2933-41 pubmed
    ..These results indicate that upcoming therapy strategies in cancer patients targeting COX-2 may be effective in inhibiting tumour vasculogenesis as well as angiogenic processes. ..
  44. Zupkovitz G, Tischler J, Posch M, Sadzak I, Ramsauer K, Egger G, et al. Negative and positive regulation of gene expression by mouse histone deacetylase 1. Mol Cell Biol. 2006;26:7913-28 pubmed
    ..Our study reveals a regulatory cross talk between HDAC1 and HDAC2 and a novel function for HDAC1 as a transcriptional coactivator. ..
  45. Bellezza I, Neuwirt H, Nemes C, Cavarretta I, Puhr M, Steiner H, et al. Suppressor of cytokine signaling-3 antagonizes cAMP effects on proliferation and apoptosis and is expressed in human prostate cancer. Am J Pathol. 2006;169:2199-208 pubmed
    ..Collectively, our results show that SOCS-3 antagonizes regulation of cellular events by cAMP and is expressed in human prostate cancer. ..
  46. Dubrac S, Stoitzner P, Pirkebner D, Elentner A, Schoonjans K, Auwerx J, et al. Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function. J Immunol. 2007;178:4362-72 pubmed
    ..In conclusion, PPARalpha activation by endogenous ligands may provide a molecular signal that allows LC to remain in an immature state within the epidermis for extended periods of time despite minor environmental stimuli. ..
  47. Artwohl M, Muth K, Kosulin K, de Martin R, Holzenbein T, Rainer G, et al. R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1. Am J Physiol Endocrinol Metab. 2007;293:E681-9 pubmed
    ..LA's ability to inhibit apoptosis and proliferation of ECs could beneficially affect endothelial dysfunction, which precedes manifestation of late diabetic vascular complications. ..
  48. Reisinger U, Schwaiger S, Zeller I, Messner B, Stigler R, Wiedemann D, et al. Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts. Cardiovasc Res. 2009;82:542-9 pubmed publisher
    ..Our data suggest that leoligin might represent a novel non-toxic, non-thrombogenic, endothelial integrity preserving candidate drug for the treatment of vein graft disease. ..
  49. Büchel G, Stepanenko I, Hejl M, Jakupec M, Arion V, Keppler B. [Os(IV)Cl(5)(Hazole)](-) complexes: synthesis, structure, spectroscopic properties, and antiproliferative activity. Inorg Chem. 2009;48:10737-47 pubmed publisher
    ..Replacement of azolium cations by sodium had significant effects; cytotoxicity increased in the case of the pyrazole system from 3 (A549) to the 5.5-fold (CH1)...
  50. Seyerl M, Kirchberger S, Majdic O, Seipelt J, Jindra C, Schrauf C, et al. Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. Eur J Immunol. 2010;40:321-9 pubmed publisher
    ..These results demonstrate a novel pathway and its components for the induction of immune-inhibitory T cells. ..
  51. Schwaiberger A, Heiss E, Cabaravdic M, Oberan T, Zaujec J, Schachner D, et al. Indirubin-3'-monoxime blocks vascular smooth muscle cell proliferation by inhibition of signal transducer and activator of transcription 3 signaling and reduces neointima formation in vivo. Arterioscler Thromb Vasc Biol. 2010;30:2475-81 pubmed publisher
  52. Wittinger M, Vanhara P, El Gazzar A, Savarese Brenner B, Pils D, Anees M, et al. hVps37A Status affects prognosis and cetuximab sensitivity in ovarian cancer. Clin Cancer Res. 2011;17:7816-27 pubmed publisher
    ..We propose that hVps37A status could become a novel prognostic and therapeutic marker for EGFR or HER2 driven tumors. ..
  53. Amin A, Bilic I, Berger E, Hess M. Trichomonas gallinae, in comparison to Tetratrichomonas gallinarum, induces distinctive cytopathogenic effects in tissue cultures. Vet Parasitol. 2012;186:196-206 pubmed publisher
    ..gallinarum filtrates was less severe than that recorded by T. gallinae. Consequently, for the first time a destruction of specified monolayers induced by T. gallinae-free filtrates could be demonstrated...
  54. Giessrigl B, Yazici G, Teichmann M, Kopf S, Ghassemi S, Atanasov A, et al. Effects of Scrophularia extracts on tumor cell proliferation, death and intravasation through lymphoendothelial cell barriers. Int J Oncol. 2012;40:2063-74 pubmed publisher
    ..S. lucida exhibited promising anti-neoplastic effects and this was most likely due to the down-regulation of various cell cycle regulators, proto-oncogenes and NF-?B and the activation of caspase-3...
  55. Prutsch N, Fock V, Haslinger P, Haider S, Fiala C, Pollheimer J, et al. The role of interleukin-1? in human trophoblast motility. Placenta. 2012;33:696-703 pubmed publisher
    ..In conclusion, these data suggest that IL-1? directly promotes trophoblast motility of first trimester EVT involving the uPA/PAI system. ..
  56. Giessrigl B, Krieger S, Rosner M, Huttary N, Saiko P, Alami M, et al. Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells. Hum Mol Genet. 2012;21:4615-27 pubmed publisher
    ..Our data show that targeting Hsp90 reduced the resistance of pancreas carcinoma cells to treatment with GEM. ..
  57. Stulnig G, Frisch M, Crnkovic S, Stiegler P, Sereinigg M, Stacher E, et al. Docosahexaenoic acid (DHA)-induced heme oxygenase-1 attenuates cytotoxic effects of DHA in vascular smooth muscle cells. Atherosclerosis. 2013;230:406-13 pubmed publisher
    ..HO-1 silencing did not affect proliferation of hPASMC exposed to DHA. Our results indicate that DHA-induced, ROS-dependent upregulation of HO-1 attenuates oxidative stress, UPR and apoptosis in DHA-treated hPASMC. ..
  58. Bétrian S, Ysebaert L, Heider K, Delord J, Fournie J, Quillet Mary A. Idelalisib improves CD37 antibody BI 836826 cytotoxicity against chemo-resistant /relapse-initiating CLL cells: a rationale for combination treatment. Blood Cancer J. 2016;6:e496 pubmed publisher
  59. Dorner D, Vlcek S, Foeger N, Gajewski A, Makolm C, Gotzmann J, et al. Lamina-associated polypeptide 2alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway. J Cell Biol. 2006;173:83-93 pubmed
    ..The effects of LAP2alpha on cell cycle progression and differentiation may be highly relevant for the cell- and tissue-specific phenotypes observed in laminopathic diseases...
  60. Fritsch Stork R, Müllegger D, Skriner K, Jahn Schmid B, Smolen J, Steiner G. The spliceosomal autoantigen heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) is a major T cell autoantigen in patients with systemic lupus erythematosus. Arthritis Res Ther. 2006;8:R118 pubmed
    ..Taken together, the pronounced peripheral T cell reactivity to hnRNP-A2 observed in the majority of SLE patients and the distinct phenotype of patient-derived CD8+ TCCs suggest a role for these T cells in the pathogenesis of SLE. ..
  61. Winkler C, Frick B, Schroecksnadel K, Schennach H, Fuchs D. Food preservatives sodium sulfite and sorbic acid suppress mitogen-stimulated peripheral blood mononuclear cells. Food Chem Toxicol. 2006;44:2003-7 pubmed
    ..01 at 1 mM sodium sulfite and 50 mM sorbic acid). Data demonstrate a suppressive influence of sodium sulfite and sorbic acid on the activated Th1-type immune response. ..
  62. Taschner S, Koesters C, Platzer B, Jörgl A, Ellmeier W, Benesch T, et al. Down-regulation of RXRalpha expression is essential for neutrophil development from granulocyte/monocyte progenitors. Blood. 2007;109:971-9 pubmed
    ..Therefore, our data suggest that RXRalpha down-regulation is a critical requirement for the generation of neutrophil granulocytes. ..
  63. Gruber T, Hermann Kleiter N, Pfeifhofer Obermair C, Lutz Nicoladoni C, Thuille N, Letschka T, et al. PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo. Mol Immunol. 2009;46:2071-9 pubmed publisher
  64. De Mulder K, Kuales G, Pfister D, Egger B, Seppi T, Eichberger P, et al. Potential of Macrostomum lignano to recover from gamma-ray irradiation. Cell Tissue Res. 2010;339:527-42 pubmed publisher
    ..lignano represents a suitable model system for elucidating the effect of irradiation on the stem cell system in flatworms and for improving our understanding of the recovery potential of severely damaged stem-cell systems...
  65. Micutkova L, Diener T, Li C, Rogowska Wrzesinska A, Mueck C, Huetter E, et al. Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts. Mech Ageing Dev. 2011;132:468-79 pubmed publisher
    ..Since IGFBP-6 overexpression increased cellular lifespan, the data suggest that IGFBP-6, in contrast to other IGF binding proteins, is a negative regulator of cellular senescence in human fibroblasts. ..
  66. Meinhardt G, Haider S, Haslinger P, Proestling K, Fiala C, Pollheimer J, et al. Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. Endocrinology. 2014;155:1908-20 pubmed publisher
    ..In summary, the data suggest that Wnt/TCF-4-dependent signaling could play a role in EVT differentiation promoting motility and expression of promigratory genes. ..
  67. Babinsky V, Hannan F, Ramracheya R, Zhang Q, Nesbit M, Hugill A, et al. Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy. Endocrinology. 2017;158:2486-2502 pubmed publisher
    ..Moreover, our findings highlight a potential application of targeted CaSR compounds for modulating glucose metabolism. ..
  68. Gleixner K, Mayerhofer M, Aichberger K, Derdak S, Sonneck K, Bohm A, et al. PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects. Blood. 2006;107:752-9 pubmed
    ..Together, PKC412 and AMN107 represent promising novel agents for targeted therapy of SM...
  69. Voglauer R, Chang M, Dampier B, Wieser M, Baumann K, Sterovsky T, et al. SNEV overexpression extends the life span of human endothelial cells. Exp Cell Res. 2006;312:746-59 pubmed
    ..These data suggest that high levels of SNEV might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells. ..
  70. Shim K, Rosner M, Freilinger A, Lubec G, Hengstschlager M. Bach2 is involved in neuronal differentiation of N1E-115 neuroblastoma cells. Exp Cell Res. 2006;312:2264-78 pubmed
    ..It would have negative effects on proliferation and differentiation of these cells. In differentiated neuronal cells Bach2 expression is upregulated, which could allow Bach2 to function as a gatekeeper of the differentiated status. ..
  71. Pfeifhofer C, Gruber T, Letschka T, Thuille N, Lutz Nicoladoni C, Hermann Kleiter N, et al. Defective IgG2a/2b class switching in PKC alpha-/- mice. J Immunol. 2006;176:6004-11 pubmed
    ..Our genetic data, thus, define PKCalpha as the physiological and nonredundant PKC isotype in signaling pathways that are necessary for T cell-dependent IFN-gamma production and IgG2a/2b Ab responses. ..
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