Genomes and Genes
Experts and Doctors on cell nucleus in United States
Locale: United States
Topic: cell nucleus
Publications543 found, 100 shown here
- Zhu J, Qiu Z, Wiese C, Ishii Y, Friedrichsen J, Rajashekara G, et al. Nuclear and mitochondrial localization signals overlap within bovine herpesvirus 1 tegument protein VP22. J Biol Chem. 2005;280:16038-44 pubmed publisher..Our findings demonstrate the diversity of VP22 protein to localize within the cell and provide the opportunity for VP22 to direct cargo specifically to different subcellular compartments...
- Inaba T, Alvarez Huerta M, Li M, Bauer J, Ewers C, Kessler F, et al. Arabidopsis tic110 is essential for the assembly and function of the protein import machinery of plastids. Plant Cell. 2005;17:1482-96 pubmed..Together, these data suggest that Tic110 plays a general role in the import of nuclear-encoded preproteins as a common component of Tic complexes. ..
- Kravchenko J, Rogozin I, Koonin E, Chumakov P. Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin. Nature. 2005;436:735-9 pubmed..The promoters for spRNAP-IV differ substantially from those used by RNA polymerase II, do not respond to transcriptional enhancers and contain a common functional sequence motif. ..
- Morinelli T, Raymond J, Baldys A, Yang Q, Lee M, Luttrell L, et al. Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activation. Am J Physiol Cell Physiol. 2007;292:C1398-408 pubmed
- Oka T, Sudol M. Nuclear localization and pro-apoptotic signaling of YAP2 require intact PDZ-binding motif. Genes Cells. 2009;14:607-15 pubmed publisher..Since the Hippo pathway acts as a tumor suppressor pathway, the PDZ complex of YAP represents a potential target of cancer therapy. ..
- Xiao L, Naganawa T, Lorenzo J, Carpenter T, Coffin J, Hurley M. Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO. J Biol Chem. 2010;285:2834-46 pubmed publisher..In addition, immunohistochemistry demonstrated co-localization of FGF23 and HMW FGF2 protein in osteoblasts and osteocytes from Hyp mice. This study reveals a novel mechanism of regulation of the FGF23-P(i) homeostatic axis...
- Sutherland B, Belaj A, Nier S, Cottrell J, P Vaughan S, Hubert J, et al. Molecular biodiversity and population structure in common ash (Fraxinus excelsior L.) in Britain: implications for conservation. Mol Ecol. 2010;19:2196-211 pubmed publisher..The data provide new information which will aid development of appropriate conservation policies for ash and other wind pollinated tree species...
- Oka T, Remue E, Meerschaert K, Vanloo B, Boucherie C, Gfeller D, et al. Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling. Biochem J. 2010;432:461-72 pubmed publisher..The present paper is the first report on a PDZ-based nuclear translocation mechanism. Moreover, since the Hippo pathway acts as a tumour suppressor pathway, the YAP2-ZO-2 complex could represent a target for cancer therapy. ..
- Adluri R, Thirunavukkarasu M, Dunna N, Zhan L, Oriowo B, Takeda K, et al. Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1? transcription factor and its target genes in mice. Antioxid Redox Signal. 2011;15:1789-97 pubmed publisher..These findings indicated that silencing of PHD-1 attenuates myocardial I/R injury probably by enhancing HIF-1?/?-catenin/endothelial nitric oxide synthase/nuclear factor-kappaB and Bcl-2 signaling pathway. ..
- Bichsel C, Neeld D, Hamazaki T, Wu D, Chang L, Yang L, et al. Bacterial delivery of nuclear proteins into pluripotent and differentiated cells. PLoS ONE. 2011;6:e16465 pubmed publisher..These results validate the use of T3SS for the delivery of transcription factors for the purpose of cellular reprogramming. ..
- Huh Y, Sherley J. Molecular cloaking of H2A.Z on mortal DNA chromosomes during nonrandom segregation. Stem Cells. 2011;29:1620-7 pubmed publisher..It also seems likely to manifest an important aspect of the underlying mechanism(s) responsible for nonrandom sister chromatid segregation in DSCs. ..
- Lockwood C, Kayisli U, Stocco C, Murk W, Vatandaslar E, Buchwalder L, et al. Abruption-induced preterm delivery is associated with thrombin-mediated functional progesterone withdrawal in decidual cells. Am J Pathol. 2012;181:2138-48 pubmed publisher..Functional withdrawal of progesterone results in increased p-ERK1/2, and is thus one pathway initiating abruption-associated PTD. ..
- Mehendale H, Purushotham K, Lockard V. The time course of liver injury and [3H]thymidine incorporation in chlordecone-potentiated CHCl3 hepatotoxicity. Exp Mol Pathol. 1989;51:31-47 pubmed..These results suggest that the critical decisive event in the recovery from limited hepatocellular injury is the hepatocellular regeneration and tissue repair, which appear to be stimulated in proportion to the injury. ..
- White K, Yore M, Warburton S, Vaseva A, Rieder E, Freemantle S, et al. Negative feedback at the level of nuclear receptor coregulation. Self-limitation of retinoid signaling by RIP140. J Biol Chem. 2003;278:43889-92 pubmed
- Fowler A, Solodin N, Preisler Mashek M, Zhang P, Lee A, Alarid E. Increases in estrogen receptor-alpha concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen. FASEB J. 2004;18:81-93 pubmed..Further, they describe a potential mechanism whereby increases in ERalpha concentration may provide a proliferative advantage by augmenting ERalpha function regardless of ligand status. ..
- Mochizuki K, Gorovsky M. Small RNAs in genome rearrangement in Tetrahymena. Curr Opin Genet Dev. 2004;14:181-7 pubmed..These findings contribute to a new paradigm of chromatin biology: regulation of heterochromatin formation by RNAi-related mechanisms in eukaryotes. ..
- Sandberg E, Wallace T, Godeny M, VonDerLinden D, Sayeski P. Jak2 tyrosine kinase: a true jak of all trades?. Cell Biochem Biophys. 2004;41:207-32 pubmed..By reviewing the biology of Jak2 tyrosine kinase at the molecular, cellular, and physiological levels, we hope to advance the understanding of how a single gene can have such a profound impact on development, physiology, and disease. ..
- Ong H, Palmer J. Pervasive survival of expressed mitochondrial rps14 pseudogenes in grasses and their relatives for 80 million years following three functional transfers to the nucleus. BMC Evol Biol. 2006;6:55 pubmed
- Kankanala P, Czymmek K, Valent B. Roles for rice membrane dynamics and plasmodesmata during biotrophic invasion by the blast fungus. Plant Cell. 2007;19:706-24 pubmed..Analysis of biotrophic blast invasion will significantly contribute to our understanding of normal plant processes and allow the characterization of secreted fungal effectors that affect these processes...
- Shelton M, Kern T, Mieyal J. Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Müller cells: model of diabetic retinopathy. J Biol Chem. 2007;282:12467-74 pubmed..Thus, GRx may represent a novel therapeutic target to inhibit diabetic retinopathy. ..
- Wong J, Korcheva V, Jacoby D, Magun B. Proinflammatory responses of human airway cells to ricin involve stress-activated protein kinases and NF-kappaB. Am J Physiol Lung Cell Mol Physiol. 2007;293:L1385-94 pubmed..Therefore, the p38 MAPK and NF-kappaB pathways are potential therapeutic targets for reducing the inflammatory consequences of ricin poisoning. ..
- Wood J, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem. 2007;282:35416-23 pubmed..These observations support that MCPH1 acts early in DNA damage responsive pathways. ..
- Chekanova J, Abruzzi K, Rosbash M, Belostotsky D. Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA. 2008;14:66-77 pubmed..Taken together with other recent findings, these observations also highlight the importance of nuclear mRNP to the mobilization of active genes to the nuclear rim. ..
- Prichard M, Sztul E, Daily S, Perry A, Frederick S, Gill R, et al. Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes. J Virol. 2008;82:5054-67 pubmed publisher..These data also suggest a potential link between RB function and the formation of aggresomes. ..
- Lindsay C, Morozov V, Ishov A. PML NBs (ND10) and Daxx: from nuclear structure to protein function. Front Biosci. 2008;13:7132-42 pubmed
- Reineke E, Kao H. Targeting promyelocytic leukemia protein: a means to regulating PML nuclear bodies. Int J Biol Sci. 2009;5:366-76 pubmed..This review focuses on the current knowledge of regulation of PML under normal cellular conditions as well as the role for regulation of PML in viral infection and cancer...
- Schulze S, Curio Penny B, Speese S, Dialynas G, Cryderman D, McDonough C, et al. A comparative study of Drosophila and human A-type lamins. PLoS ONE. 2009;4:e7564 pubmed publisher..These studies provide new insights on the role of lamins in nuclear biology and support Drosophila as a model for studies of human laminopathies involving muscle dysfunction. ..
- Dahlman J, Guttridge D. Detection of NF-?B activity in skeletal muscle cells by electrophoretic mobility shift analysis. Methods Mol Biol. 2012;798:505-16 pubmed publisher..Here, we describe the methodology used to isolate the cytoplasmic and nuclear protein extracts from both cultured cells and tissues and utilize the nuclear protein fraction to assess NF-?B DNA-binding activity by EMSA analysis. ..
- Litchfield L, Riggs K, Hockenberry A, Oliver L, Barnhart K, Cai J, et al. Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor ? transcription in breast cancer cells. PLoS ONE. 2012;7:e38278 pubmed publisher..Our data indicate that nucleolin plays a coregulatory role in transcriptional regulation of the tumor suppressor RARB2 by COUP-TFII. ..
- Choudhary A, Lera R, Martowicz M, Oxendine K, Laffin J, Weaver B, et al. Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis. Proc Natl Acad Sci U S A. 2013;110:13026-31 pubmed publisher..Thus, traction-mediated cytofission, originally observed in Dictyostelium, is relevant to human biology--where it seems to be an evolutionarily conserved mechanism that can preserve genomic integrity. ..
- Aslam M, Hettmer S, Abraham J, LaTocha D, Soundararajan A, Huang E, et al. Dynamic and nuclear expression of PDGFR? and IGF-1R in alveolar Rhabdomyosarcoma. Mol Cancer Res. 2013;11:1303-13 pubmed publisher..RTK expression status and subcellular localization dynamics are important considerations for personalized medicine. ..
- Munsell E, Ross N, Sullivan M. Journey to the Center of the Cell: Current Nanocarrier Design Strategies Targeting Biopharmaceuticals to the Cytoplasm and Nucleus. Curr Pharm Des. 2016;22:1227-44 pubmed..Understanding these mechanisms has enabled advances in synthetic peptide and polymer design that may ultimately improve intracellular trafficking and bioavailability, leading to increased access to new classes of biotherapeutics. ..
- Wilson S, Datar K, Paddy M, Swedlow J, Swanson M. Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. J Cell Biol. 1994;127:1173-84 pubmed..These results suggest that the Nab proteins may be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing. ..
- Preer J. Epigenetic mechanisms affecting macronuclear development in Paramecium and Tetrahymena. J Eukaryot Microbiol. 2000;47:515-24 pubmed..They constitute a major feature of ciliate genetics, probably because the separation of generative and vegetative functions to micronuclei and macronuclei makes such changes possible...
- Chadwick B, Willard H. Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. Hum Mol Genet. 2001;10:1101-13 pubmed..This study provides further information about the nucleosomal composition of chromatin on the inactive X chromosome and indicates that a number of H2A variants are non-randomly distributed on the active and inactive X chromosomes. ..
- Parker L, Fierro Monti I, Mathews M. Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase. J Biol Chem. 2001;276:32522-30 pubmed..The C-terminal region also inhibits PKR function, probably through competitive binding to dsRNA. A model for NF90-PKR interactions is proposed. ..
- Duncan M, Cui W, Oh D, Tomarev S. Prox1 is differentially localized during lens development. Mech Dev. 2002;112:195-8 pubmed..Thus, it appears that the function of Prox1, like that of its Drosophila cognate Prospero, is at least partially controlled by changes in its subcellular distribution during development. ..
- Qanungo S, Haldar S, Basu A. Restoration of silenced Peutz-Jeghers syndrome gene, LKB1, induces apoptosis in pancreatic carcinoma cells. Neoplasia. 2003;5:367-74 pubmed publisher..This suggests that LKB1-induced apoptosis is p53 independent but might be p73-mediated in the pancreatic tumor cell line, AsPC-1. ..
- Quesada I, Martin F, Roche E, Soria B. Nutrients induce different Ca(2+) signals in cytosol and nucleus in pancreatic beta-cells. Diabetes. 2004;53 Suppl 1:S92-5 pubmed..These amplitude-modulated Ca(2+) signals transmitted to the nucleus might play an important role in the control of gene expression in the pancreatic beta-cell. ..
- Yuan G, Nanduri J, Bhasker C, Semenza G, Prabhakar N. Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. J Biol Chem. 2005;280:4321-8 pubmed..These observations suggest that IH induces HIF-1 transcriptional activity via a novel signaling pathway involving CaM kinase. ..
- Butcher G, Lee B, Cheng H, Obrietan K. Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism. J Neurosci. 2005;25:5305-13 pubmed..Together, these data identify MSK1 as both a downstream target of the MAPK cascade within the SCN and a regulator of clock gene expression. ..
- Harris B, Spruill L, Edmonson A, Rackley M, Benson D, O Brien T, et al. Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2-5 expression. Dev Dyn. 2006;235:38-49 pubmed..We conclude that a prerequisite for normal Purkinje fiber maturation is precise regulation of Nkx2-5 levels. ..
- Migone F, DeInnocentes P, Smith B, Bird R. Alterations in CDK1 expression and nuclear/nucleolar localization following induction in a spontaneous canine mammary cancer model. J Cell Biochem. 2006;98:504-18 pubmed
- Barkan A, Klipcan L, Ostersetzer O, Kawamura T, Asakura Y, Watkins K. The CRM domain: an RNA binding module derived from an ancient ribosome-associated protein. RNA. 2007;13:55-64 pubmed
- Aldonyte R, Ruta A, Brantly M, Mark B, Block E, Edward B, et al. Nuclear localization of active matrix metalloproteinase-2 in cigarette smoke-exposed apoptotic endothelial cells. Exp Lung Res. 2009;35:59-75 pubmed publisher..This suggests a novel function of MMP-2 in the degradation of the nuclear matrix in CS-induced endothelial apoptosis. ..
- Huynh L, Thangavel M, Chen T, Cottrell R, Mitchell J, Praetorius Ibba M. Linking tRNA localization with activation of nutritional stress responses. Cell Cycle. 2010;9:3112-8 pubmed publisher..This suggests that subcellular localization of tRNAs may regulate an intracellular response to starvation independently of the cellular nutritional status. ..
- Kemler I, Saenz D, Poeschla E. Feline immunodeficiency virus Gag is a nuclear shuttling protein. J Virol. 2012;86:8402-11 pubmed publisher..These findings expand the spectrum of lentiviral Gag behaviors and raise the possibility that FIV genome encapsidation may initiate in the nucleus...
- Xiao L, Esliger A, Hurley M. Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro. J Bone Miner Res. 2013;28:35-45 pubmed publisher..Our results suggest that phosphate-independent effects of HMW isoforms in vitro may be directly mediated in part via FGF23 and that HMW isoforms signal via FGF23/FGFR/MAPK to inhibit bone formation in vitro. ..
- Nowsheen S, Cooper T, Stanley J, Yang E. Synthetic lethal interactions between EGFR and PARP inhibition in human triple negative breast cancer cells. PLoS ONE. 2012;7:e46614 pubmed publisher..Additionally, a contextual synthetic lethality may exist between combined EGFR and PARP inhibitors. ..
- Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S. Genome wide array analysis indicates that an amyotrophic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitro. Biochim Biophys Acta. 2013;1832:1129-35 pubmed publisher..It indicates that, despite the obvious cytoplasmic accumulation, FUS-?NLS can act through a nuclear gain of function mechanism. ..
- Brudecki L, Ferguson D, McCall C, El Gazzar M. MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes. Immunol Cell Biol. 2013;91:532-40 pubmed publisher..We conclude that miR-146a has a diverse and critical role in limiting an excessive acute inflammatory reaction. ..
- May V, Buttolph T, Girard B, Clason T, Parsons R. PACAP-induced ERK activation in HEK cells expressing PAC1 receptors involves both receptor internalization and PKC signaling. Am J Physiol Cell Physiol. 2014;306:C1068-79 pubmed publisher..In sum, our results show that PACAP/PAC1 receptor endocytosis and PLC/diacylglycerol/PKC activation represent two complementary mechanisms contributing to PACAP-induced ERK activation. ..
- Li W, Li W, Laishram R, Hoque M, Ji Z, Tian B, et al. Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases. Nucleic Acids Res. 2017;45:8930-8942 pubmed publisher..The Star-PAP-mediated APA of PTEN is essential for DNA damage-induced increase of PTEN protein levels. Together, our results reveal a PAS-guided and PAP-mediated paradigm for gene expression in response to cellular signaling cues. ..
- Pritchard D, Schubiger G. Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio. Genes Dev. 1996;10:1131-42 pubmed
- Shaw L, Lewin A. The Cbp2 protein stimulates the splicing of the omega intron of yeast mitochondria. Nucleic Acids Res. 1997;25:1597-604 pubmed
- Gross S, Simerly C, Schatten G, Anderson R. A casein kinase I isoform is required for proper cell cycle progression in the fertilized mouse oocyte. J Cell Sci. 1997;110 ( Pt 24):3083-90 pubmed..These results suggest that the kinase regulates the progression from interphase to mitosis during the first cell cycle. ..
- Bokar J, Shambaugh M, Polayes D, Matera A, Rottman F. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA. 1997;3:1233-47 pubmed..MT-A70 also contains a long region of homology to the yeast protein SPO8, which is involved in induction of sporulation by an unknown mechanism. ..
- Laughner B, Sehnke P, Ferl R. A novel nuclear member of the thioredoxin superfamily. Plant Physiol. 1998;118:987-96 pubmed
- Lavoie H, DeSimone D, Gillio Meina C, Hui Y. Cloning and characterization of porcine ovarian estrogen receptor beta isoforms. Biol Reprod. 2002;66:616-23 pubmed..ER beta is abundant in porcine ovary, and a naturally occurring splice variant missing exon 5 may have biological function. ..
- Costantino M, Stearman R, Smith G, Darling D. Cell-specific phosphorylation of Zfhep transcription factor. Biochem Biophys Res Commun. 2002;296:368-73 pubmed..These data provide the first demonstration that Zfhep is post-translationally modified. ..
- Li F, Chen J, Solessio E, Gilbert D. Spatial distribution and specification of mammalian replication origins during G1 phase. J Cell Biol. 2003;161:257-66 pubmed..These results highlight two distinct G1 steps that establish a spatial and temporal program for replication. ..
- Muresan Z, Muresan V. A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment. Hum Mol Genet. 2004;13:475-88 pubmed..These results suggest that phosphorylated Cgamma accumulates at the SFC. Thus, APP may play a role in pre-mRNA splicing, and Fe65 and APP phosphorylation may regulate this function. ..
- Wang M, Qanungo S, Crow M, Watanabe M, Nieminen A. Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei. FEBS Lett. 2005;579:2411-5 pubmed..These findings indicate that ARC is distributed differently in cancer cells than non-cancer cells and thus might play a role in neoplastic transformation. ..
- Shimojo M. Characterization of the nuclear targeting signal of REST/NRSF. Neurosci Lett. 2006;398:161-6 pubmed..A point mutation in the zinc finger structure that disrupts its conformation remains nuclear. These data suggest that REST/NRSF contains a NLS around ZFD-5, while the putative NLS at residues 512-522 is non-functional. ..
- Hosseinpour F, Timsit Y, Koike C, Matsui K, Yamamoto Y, Moore R, et al. Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver. FEBS Lett. 2007;581:4937-42 pubmed..CAR directly bound to the PH domain. Thus, ECT2 may comprise a part of the PB response signal regulating the intracellular trafficking of CAR. ..
- Kelley T, Baz R, Hussein M, Karafa M, Cook J. Clinical significance of cyclin D1, fibroblast growth factor receptor 3, and p53 immunohistochemistry in plasma cell myeloma treated with a thalidomide-based regimen. Hum Pathol. 2009;40:405-12 pubmed publisher..The findings suggest that a thalidomide-based regimen may overcome the poor prognosis associated with a cyclin D1-negative or fibroblast growth factor receptor 3-positive phenotype. ..
- Zhang Q, Wang Y. HMG modifications and nuclear function. Biochim Biophys Acta. 2010;1799:28-36 pubmed publisher..In this review, we focus on the chemical modifications of mammalian HMG proteins and highlight their roles in nuclear functions. ..
- Sanduja S, Kaza V, Dixon D. The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase. Aging (Albany NY). 2009;1:803-17 pubmed..These findings demonstrate the ability of TTP to act as a tumor suppressor by inhibiting the E6-AP pathway and indicate TTP loss to be a critical event during HPV-mediated carcinogenesis. ..
- You S, Zuo L, Varma V. Broad tissue expression of membrane progesterone receptor Alpha in normal mice. J Mol Histol. 2010;41:101-10 pubmed publisher..Our results indicate that mPRalpha may function as a key modulator of P4 in the modulation of multiple physiological functions in normal mice. ..
- Hussain S, Gallagher T. SARS-coronavirus protein 6 conformations required to impede protein import into the nucleus. Virus Res. 2010;153:299-304 pubmed publisher..These findings are discussed in the context of the proposed protein 6 structure. ..
- Schramp M, Thapa N, Heck J, Anderson R. PIPKI? regulates ?-catenin transcriptional activity downstream of growth factor receptor signaling. Cancer Res. 2011;71:1282-91 pubmed publisher..These results reveal a novel mechanism in which PIPKI? expression and catalytic activity enhance ?-catenin nuclear translocation and expression of its target genes to promote tumorigenic phenotypes. ..
- Burton N, Burkhart K, Kennedy S. Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2011;108:19683-8 pubmed publisher..These results demonstrate that siRNA expression is heritable in C. elegans and define an RNAi pathway that promotes the maintenance of RNAi silencing and siRNA expression in the progeny of animals exposed to dsRNA. ..
- Schleit J, Wall V, Simko M, Kaeberlein M. The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans. PLoS ONE. 2011;6:e28036 pubmed publisher..This increased metabolic activation appears to be mediated through the MDT-15 transcription factor and is independent of the IIS pathway. ..
- Li Z, Musich P, Serrano M, Dong Z, Zou Y. XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase. PLoS ONE. 2011;6:e28326 pubmed publisher..In contrast, the nuclear import of XPA in G(1) or G(2) phase appears to be largely independent of DNA damage and p53. ..
- Karkhanis V, Wang L, Tae S, Hu Y, Imbalzano A, SIF S. Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase ? catalytic subunit gene, POLD1. J Biol Chem. 2012;287:29801-14 pubmed publisher..These results provide evidence for the important role played by PRMT7 in epigenetic regulation of DNA repair genes and cellular response to DNA damage. ..
- Bhatnagar A, Unal H, Jagannathan R, Kaveti S, Duan Z, Yong S, et al. Interaction of G-protein ?? complex with chromatin modulates GPCR-dependent gene regulation. PLoS ONE. 2013;8:e52689 pubmed publisher..These findings suggest a wide-ranging mechanism by which direct interaction of G?? with specific chromatin bound transcription factors regulates functional gene networks in response to GPCR activation in cells. ..
- Sizemore N, Leung S, Stark G. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol Cell Biol. 1999;19:4798-805 pubmed..Therefore, IL-1 stimulates the PI3K-dependent phosphorylation and transactivation of NF-kappaB, a process quite distinct from the liberation of NF-kappaB from its cytoplasmic inhibitor IkappaB. ..
- Campbell Thompson M, Reyher K, Wilkinson L. Immunolocalization of estrogen receptor alpha and beta in gastric epithelium and enteric neurons. J Endocrinol. 2001;171:65-73 pubmed..Our findings imply that direct regulation of multiple cell types by estrogens may contribute to the modulation of gastric functions that have been recognized during the estrous cycle and between the sexes. ..
- Ramilo C, Gu L, Guo S, Zhang X, Patrick S, Turchi J, et al. Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A. Mol Cell Biol. 2002;22:2037-46 pubmed..It is anticipated that further analysis of these fractions will identify additional MMR components and enable the complete reconstitution of the human MMR pathway with purified proteins. ..
- Tasheva E, An K, Boyle D, Conrad G. Expression and localization of leucine-rich B7 protein in human ocular tissues. Mol Vis. 2005;11:452-60 pubmed..The results reported here are an essential prerequisite for future studies aimed at understanding the biological roles of leucine-rich B7 proteins in health and disease. ..
- Minaguchi T, Waite K, Eng C. Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein. Cancer Res. 2006;66:11677-82 pubmed..Collectively, our data present evidence of a novel crosstalk between the Ca(2+) signaling-mediated regulation of the cell cycle and MVP-mediated nuclear PTEN localization and function. ..
- Sun Y, An S, Henrich V, Sun X, Song Q. Proteomic identification of PKC-mediated expression of 20E-induced protein in Drosophila melanogaster. J Proteome Res. 2007;6:4478-88 pubmed publisher..The data further indicate that PKC-mediated phosphorylation is also required for genes regulated indirectly by 20E-induced changes in the larval salivary gland...
- Wu P, Hung S, Ren T, Shih I, Tseng Y. Cell cycle-dependent alteration in NAC1 nuclear body dynamics and morphology. Phys Biol. 2011;8:015005 pubmed publisher..These results indicate that a cell cycle-dependent regulatory mechanism controls NAC1 body formation in the nucleus and suggest that NAC1 body dynamics are associated with mitosis or cytokinesis. ..
- Czarnecka Verner E, Yuan C, Fox P, Gurley W. Isolation and characterization of six heat shock transcription factor cDNA clones from soybean. Plant Mol Biol. 1995;29:37-51 pubmed..The carboxy-terminal domains are reduced in size and the C-terminal heptad repeat is degenerate...
- Thompson E, Olsson P, Mayer G, Haux C, Walsh P, Burge E, et al. Effects of 17 beta-estradiol on levels and distribution of metallothionein and zinc in squirrelfish. Am J Physiol Regul Integr Comp Physiol. 2001;280:R527-35 pubmed..Thus E(2) is probably responsible for the association of MT with the nuclear fraction previously observed in untreated mature female squirrelfish...
- Hu Y, Yeh S, Yeh S, Sampson E, Huang J, Li P, et al. Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. J Biol Chem. 2004;279:33438-46 pubmed
- Yoo H, Shevchenko A, Shevchenko A, Dunphy W. Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. J Biol Chem. 2004;279:53353-64 pubmed..These experiments indicate that ATM and ATR phosphorylate the functionally critical replication protein Mcm2 during both DNA damage and replication checkpoint responses in Xenopus egg extracts. ..
- Yamashita M, Emerman M. The cell cycle independence of HIV infections is not determined by known karyophilic viral elements. PLoS Pathog. 2005;1:e18 pubmed