Experts and Doctors on cell nucleus in United States

Summary

Locale: United States
Topic: cell nucleus

Top Publications

  1. Chapman J, Curley R. Affinity purification of retinoic acid-binding proteins using immobilized 4-(2-hydroxyethoxy)retinoic acid. Protein Expr Purif. 1990;1:63-9 pubmed
    ..The affinity phase has been used for 6 months without any detectable loss in its ability to purify cellular retinoic acid-binding protein. ..
  2. Penton A, Selleck S, Hoffmann F. Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development. Science. 1997;275:203-6 pubmed
    ..DPP may affect cell cycle synchronization by promoting cell cycle progression through the G2-M phases. This synchronization is critical for the precise assembly of the eye. ..
  3. Shi J, Sugrue S. Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus. J Biol Chem. 2000;275:14910-5 pubmed
    ..Coupled with our previous morphological observations and transfection studies, these data suggest that pinin may play a role in epithelial cell adhesion and the IF complex through a direct interaction with the keratin filaments. ..
  4. Ueda Y, Fukiage C, Shih M, Shearer T, David L. Mass measurements of C-terminally truncated alpha-crystallins from two-dimensional gels identify Lp82 as a major endopeptidase in rat lens. Mol Cell Proteomics. 2002;1:357-65 pubmed
    ..The methodology that allowed accurate mass measurements of proteins eluted from 2D gels should be useful to examine rapidly other post-translational modifications. ..
  5. Fan C, Liu M, Wang Q. Functional analysis of TBX5 missense mutations associated with Holt-Oram syndrome. J Biol Chem. 2003;278:8780-5 pubmed
    ..5, and loss of synergy in transcriptional activation between these two proteins, as well as impairment in the nuclear localization of TBX5. These defects are likely central to the pathogenesis of Holt-Oram syndrome. ..
  6. Tagliarino C, Pink J, Reinicke K, Simmers S, Wuerzberger Davis S, Boothman D. Mu-calpain activation in beta-lapachone-mediated apoptosis. Cancer Biol Ther. 2003;2:141-52 pubmed
    ..The ability of beta-lap to trigger an apparently novel, p53-independent, calpain-mediated apoptotic cell death further support the development of this drug for improved breast cancer therapy. ..
  7. Wu C, Yamaguchi Y, Benjamin L, Horvat Gordon M, Washinsky J, Enerly E, et al. NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev. 2003;17:1402-14 pubmed
    ..The transcriptional activator, HSF, might cause NELF to dissociate from the elongation complex. DSIF continues to associate with the elongation complex and could serve a positive role in elongation. ..
  8. Delisle B, Anderson C, Balijepalli R, Anson B, Kamp T, January C. Thapsigargin selectively rescues the trafficking defective LQT2 channels G601S and F805C. J Biol Chem. 2003;278:35749-54 pubmed
    ..e. LQT2 and cystic fibrosis). ..
  9. Boskovic G, Niles R. T-box binding protein type two (TBX2) is an immediate early gene target in retinoic-acid-treated B16 murine melanoma cells. Exp Cell Res. 2004;295:281-9 pubmed
    ..This oligonucleotide also specifically bound RAR in nuclear extracts from B16 cells. TBX2 expression and its induction by retinoic acid was also observed in normal human and nonmalignant mouse melanocytes. ..

More Information

Publications543 found, 100 shown here

  1. Zhu J, Qiu Z, Wiese C, Ishii Y, Friedrichsen J, Rajashekara G, et al. Nuclear and mitochondrial localization signals overlap within bovine herpesvirus 1 tegument protein VP22. J Biol Chem. 2005;280:16038-44 pubmed publisher
    ..Our findings demonstrate the diversity of VP22 protein to localize within the cell and provide the opportunity for VP22 to direct cargo specifically to different subcellular compartments...
  2. Inaba T, Alvarez Huerta M, Li M, Bauer J, Ewers C, Kessler F, et al. Arabidopsis tic110 is essential for the assembly and function of the protein import machinery of plastids. Plant Cell. 2005;17:1482-96 pubmed
    ..Together, these data suggest that Tic110 plays a general role in the import of nuclear-encoded preproteins as a common component of Tic complexes. ..
  3. Kravchenko J, Rogozin I, Koonin E, Chumakov P. Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin. Nature. 2005;436:735-9 pubmed
    ..The promoters for spRNAP-IV differ substantially from those used by RNA polymerase II, do not respond to transcriptional enhancers and contain a common functional sequence motif. ..
  4. Morinelli T, Raymond J, Baldys A, Yang Q, Lee M, Luttrell L, et al. Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activation. Am J Physiol Cell Physiol. 2007;292:C1398-408 pubmed
  5. Oka T, Sudol M. Nuclear localization and pro-apoptotic signaling of YAP2 require intact PDZ-binding motif. Genes Cells. 2009;14:607-15 pubmed publisher
    ..Since the Hippo pathway acts as a tumor suppressor pathway, the PDZ complex of YAP represents a potential target of cancer therapy. ..
  6. Xiao L, Naganawa T, Lorenzo J, Carpenter T, Coffin J, Hurley M. Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO. J Biol Chem. 2010;285:2834-46 pubmed publisher
    ..In addition, immunohistochemistry demonstrated co-localization of FGF23 and HMW FGF2 protein in osteoblasts and osteocytes from Hyp mice. This study reveals a novel mechanism of regulation of the FGF23-P(i) homeostatic axis...
  7. Sutherland B, Belaj A, Nier S, Cottrell J, P Vaughan S, Hubert J, et al. Molecular biodiversity and population structure in common ash (Fraxinus excelsior L.) in Britain: implications for conservation. Mol Ecol. 2010;19:2196-211 pubmed publisher
    ..The data provide new information which will aid development of appropriate conservation policies for ash and other wind pollinated tree species...
  8. Oka T, Remue E, Meerschaert K, Vanloo B, Boucherie C, Gfeller D, et al. Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling. Biochem J. 2010;432:461-72 pubmed publisher
    ..The present paper is the first report on a PDZ-based nuclear translocation mechanism. Moreover, since the Hippo pathway acts as a tumour suppressor pathway, the YAP2-ZO-2 complex could represent a target for cancer therapy. ..
  9. Adluri R, Thirunavukkarasu M, Dunna N, Zhan L, Oriowo B, Takeda K, et al. Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1? transcription factor and its target genes in mice. Antioxid Redox Signal. 2011;15:1789-97 pubmed publisher
    ..These findings indicated that silencing of PHD-1 attenuates myocardial I/R injury probably by enhancing HIF-1?/?-catenin/endothelial nitric oxide synthase/nuclear factor-kappaB and Bcl-2 signaling pathway. ..
  10. Bichsel C, Neeld D, Hamazaki T, Wu D, Chang L, Yang L, et al. Bacterial delivery of nuclear proteins into pluripotent and differentiated cells. PLoS ONE. 2011;6:e16465 pubmed publisher
    ..These results validate the use of T3SS for the delivery of transcription factors for the purpose of cellular reprogramming. ..
  11. Huh Y, Sherley J. Molecular cloaking of H2A.Z on mortal DNA chromosomes during nonrandom segregation. Stem Cells. 2011;29:1620-7 pubmed publisher
    ..It also seems likely to manifest an important aspect of the underlying mechanism(s) responsible for nonrandom sister chromatid segregation in DSCs. ..
  12. Lockwood C, Kayisli U, Stocco C, Murk W, Vatandaslar E, Buchwalder L, et al. Abruption-induced preterm delivery is associated with thrombin-mediated functional progesterone withdrawal in decidual cells. Am J Pathol. 2012;181:2138-48 pubmed publisher
    ..Functional withdrawal of progesterone results in increased p-ERK1/2, and is thus one pathway initiating abruption-associated PTD. ..
  13. Mehendale H, Purushotham K, Lockard V. The time course of liver injury and [3H]thymidine incorporation in chlordecone-potentiated CHCl3 hepatotoxicity. Exp Mol Pathol. 1989;51:31-47 pubmed
    ..These results suggest that the critical decisive event in the recovery from limited hepatocellular injury is the hepatocellular regeneration and tissue repair, which appear to be stimulated in proportion to the injury. ..
  14. White K, Yore M, Warburton S, Vaseva A, Rieder E, Freemantle S, et al. Negative feedback at the level of nuclear receptor coregulation. Self-limitation of retinoid signaling by RIP140. J Biol Chem. 2003;278:43889-92 pubmed
  15. Fowler A, Solodin N, Preisler Mashek M, Zhang P, Lee A, Alarid E. Increases in estrogen receptor-alpha concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen. FASEB J. 2004;18:81-93 pubmed
    ..Further, they describe a potential mechanism whereby increases in ERalpha concentration may provide a proliferative advantage by augmenting ERalpha function regardless of ligand status. ..
  16. Mochizuki K, Gorovsky M. Small RNAs in genome rearrangement in Tetrahymena. Curr Opin Genet Dev. 2004;14:181-7 pubmed
    ..These findings contribute to a new paradigm of chromatin biology: regulation of heterochromatin formation by RNAi-related mechanisms in eukaryotes. ..
  17. Sandberg E, Wallace T, Godeny M, VonDerLinden D, Sayeski P. Jak2 tyrosine kinase: a true jak of all trades?. Cell Biochem Biophys. 2004;41:207-32 pubmed
    ..By reviewing the biology of Jak2 tyrosine kinase at the molecular, cellular, and physiological levels, we hope to advance the understanding of how a single gene can have such a profound impact on development, physiology, and disease. ..
  18. Ong H, Palmer J. Pervasive survival of expressed mitochondrial rps14 pseudogenes in grasses and their relatives for 80 million years following three functional transfers to the nucleus. BMC Evol Biol. 2006;6:55 pubmed
  19. Kankanala P, Czymmek K, Valent B. Roles for rice membrane dynamics and plasmodesmata during biotrophic invasion by the blast fungus. Plant Cell. 2007;19:706-24 pubmed
    ..Analysis of biotrophic blast invasion will significantly contribute to our understanding of normal plant processes and allow the characterization of secreted fungal effectors that affect these processes...
  20. Shelton M, Kern T, Mieyal J. Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Müller cells: model of diabetic retinopathy. J Biol Chem. 2007;282:12467-74 pubmed
    ..Thus, GRx may represent a novel therapeutic target to inhibit diabetic retinopathy. ..
  21. Wong J, Korcheva V, Jacoby D, Magun B. Proinflammatory responses of human airway cells to ricin involve stress-activated protein kinases and NF-kappaB. Am J Physiol Lung Cell Mol Physiol. 2007;293:L1385-94 pubmed
    ..Therefore, the p38 MAPK and NF-kappaB pathways are potential therapeutic targets for reducing the inflammatory consequences of ricin poisoning. ..
  22. Wood J, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem. 2007;282:35416-23 pubmed
    ..These observations support that MCPH1 acts early in DNA damage responsive pathways. ..
  23. Chekanova J, Abruzzi K, Rosbash M, Belostotsky D. Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA. 2008;14:66-77 pubmed
    ..Taken together with other recent findings, these observations also highlight the importance of nuclear mRNP to the mobilization of active genes to the nuclear rim. ..
  24. Prichard M, Sztul E, Daily S, Perry A, Frederick S, Gill R, et al. Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes. J Virol. 2008;82:5054-67 pubmed publisher
    ..These data also suggest a potential link between RB function and the formation of aggresomes. ..
  25. Lindsay C, Morozov V, Ishov A. PML NBs (ND10) and Daxx: from nuclear structure to protein function. Front Biosci. 2008;13:7132-42 pubmed
  26. Quadros P, Schlueter L, Wagner C. Distribution of progesterone receptor immunoreactivity in the midbrain and hindbrain of postnatal rats. Dev Neurobiol. 2008;68:1378-90 pubmed publisher
  27. Reineke E, Kao H. Targeting promyelocytic leukemia protein: a means to regulating PML nuclear bodies. Int J Biol Sci. 2009;5:366-76 pubmed
    ..This review focuses on the current knowledge of regulation of PML under normal cellular conditions as well as the role for regulation of PML in viral infection and cancer...
  28. Schulze S, Curio Penny B, Speese S, Dialynas G, Cryderman D, McDonough C, et al. A comparative study of Drosophila and human A-type lamins. PLoS ONE. 2009;4:e7564 pubmed publisher
    ..These studies provide new insights on the role of lamins in nuclear biology and support Drosophila as a model for studies of human laminopathies involving muscle dysfunction. ..
  29. Dahlman J, Guttridge D. Detection of NF-?B activity in skeletal muscle cells by electrophoretic mobility shift analysis. Methods Mol Biol. 2012;798:505-16 pubmed publisher
    ..Here, we describe the methodology used to isolate the cytoplasmic and nuclear protein extracts from both cultured cells and tissues and utilize the nuclear protein fraction to assess NF-?B DNA-binding activity by EMSA analysis. ..
  30. Litchfield L, Riggs K, Hockenberry A, Oliver L, Barnhart K, Cai J, et al. Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor ? transcription in breast cancer cells. PLoS ONE. 2012;7:e38278 pubmed publisher
    ..Our data indicate that nucleolin plays a coregulatory role in transcriptional regulation of the tumor suppressor RARB2 by COUP-TFII. ..
  31. Saud S, Young M, Jones Hall Y, Ileva L, Evbuomwan M, Wise J, et al. Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin. Cancer Res. 2013;73:5473-84 pubmed publisher
  32. Choudhary A, Lera R, Martowicz M, Oxendine K, Laffin J, Weaver B, et al. Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis. Proc Natl Acad Sci U S A. 2013;110:13026-31 pubmed publisher
    ..Thus, traction-mediated cytofission, originally observed in Dictyostelium, is relevant to human biology--where it seems to be an evolutionarily conserved mechanism that can preserve genomic integrity. ..
  33. Aslam M, Hettmer S, Abraham J, LaTocha D, Soundararajan A, Huang E, et al. Dynamic and nuclear expression of PDGFR? and IGF-1R in alveolar Rhabdomyosarcoma. Mol Cancer Res. 2013;11:1303-13 pubmed publisher
    ..RTK expression status and subcellular localization dynamics are important considerations for personalized medicine. ..
  34. Munsell E, Ross N, Sullivan M. Journey to the Center of the Cell: Current Nanocarrier Design Strategies Targeting Biopharmaceuticals to the Cytoplasm and Nucleus. Curr Pharm Des. 2016;22:1227-44 pubmed
    ..Understanding these mechanisms has enabled advances in synthetic peptide and polymer design that may ultimately improve intracellular trafficking and bioavailability, leading to increased access to new classes of biotherapeutics. ..
  35. Wilson S, Datar K, Paddy M, Swedlow J, Swanson M. Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. J Cell Biol. 1994;127:1173-84 pubmed
    ..These results suggest that the Nab proteins may be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing. ..
  36. Preer J. Epigenetic mechanisms affecting macronuclear development in Paramecium and Tetrahymena. J Eukaryot Microbiol. 2000;47:515-24 pubmed
    ..They constitute a major feature of ciliate genetics, probably because the separation of generative and vegetative functions to micronuclei and macronuclei makes such changes possible...
  37. Chadwick B, Willard H. Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. Hum Mol Genet. 2001;10:1101-13 pubmed
    ..This study provides further information about the nucleosomal composition of chromatin on the inactive X chromosome and indicates that a number of H2A variants are non-randomly distributed on the active and inactive X chromosomes. ..
  38. Parker L, Fierro Monti I, Mathews M. Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase. J Biol Chem. 2001;276:32522-30 pubmed
    ..The C-terminal region also inhibits PKR function, probably through competitive binding to dsRNA. A model for NF90-PKR interactions is proposed. ..
  39. Duncan M, Cui W, Oh D, Tomarev S. Prox1 is differentially localized during lens development. Mech Dev. 2002;112:195-8 pubmed
    ..Thus, it appears that the function of Prox1, like that of its Drosophila cognate Prospero, is at least partially controlled by changes in its subcellular distribution during development. ..
  40. Qanungo S, Haldar S, Basu A. Restoration of silenced Peutz-Jeghers syndrome gene, LKB1, induces apoptosis in pancreatic carcinoma cells. Neoplasia. 2003;5:367-74 pubmed publisher
    ..This suggests that LKB1-induced apoptosis is p53 independent but might be p73-mediated in the pancreatic tumor cell line, AsPC-1. ..
  41. Quesada I, Martin F, Roche E, Soria B. Nutrients induce different Ca(2+) signals in cytosol and nucleus in pancreatic beta-cells. Diabetes. 2004;53 Suppl 1:S92-5 pubmed
    ..These amplitude-modulated Ca(2+) signals transmitted to the nucleus might play an important role in the control of gene expression in the pancreatic beta-cell. ..
  42. Yuan G, Nanduri J, Bhasker C, Semenza G, Prabhakar N. Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. J Biol Chem. 2005;280:4321-8 pubmed
    ..These observations suggest that IH induces HIF-1 transcriptional activity via a novel signaling pathway involving CaM kinase. ..
  43. Butcher G, Lee B, Cheng H, Obrietan K. Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism. J Neurosci. 2005;25:5305-13 pubmed
    ..Together, these data identify MSK1 as both a downstream target of the MAPK cascade within the SCN and a regulator of clock gene expression. ..
  44. Harris B, Spruill L, Edmonson A, Rackley M, Benson D, O Brien T, et al. Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2-5 expression. Dev Dyn. 2006;235:38-49 pubmed
    ..We conclude that a prerequisite for normal Purkinje fiber maturation is precise regulation of Nkx2-5 levels. ..
  45. Migone F, DeInnocentes P, Smith B, Bird R. Alterations in CDK1 expression and nuclear/nucleolar localization following induction in a spontaneous canine mammary cancer model. J Cell Biochem. 2006;98:504-18 pubmed
  46. Barkan A, Klipcan L, Ostersetzer O, Kawamura T, Asakura Y, Watkins K. The CRM domain: an RNA binding module derived from an ancient ribosome-associated protein. RNA. 2007;13:55-64 pubmed
  47. Aldonyte R, Ruta A, Brantly M, Mark B, Block E, Edward B, et al. Nuclear localization of active matrix metalloproteinase-2 in cigarette smoke-exposed apoptotic endothelial cells. Exp Lung Res. 2009;35:59-75 pubmed publisher
    ..This suggests a novel function of MMP-2 in the degradation of the nuclear matrix in CS-induced endothelial apoptosis. ..
  48. Huynh L, Thangavel M, Chen T, Cottrell R, Mitchell J, Praetorius Ibba M. Linking tRNA localization with activation of nutritional stress responses. Cell Cycle. 2010;9:3112-8 pubmed publisher
    ..This suggests that subcellular localization of tRNAs may regulate an intracellular response to starvation independently of the cellular nutritional status. ..
  49. Kemler I, Saenz D, Poeschla E. Feline immunodeficiency virus Gag is a nuclear shuttling protein. J Virol. 2012;86:8402-11 pubmed publisher
    ..These findings expand the spectrum of lentiviral Gag behaviors and raise the possibility that FIV genome encapsidation may initiate in the nucleus...
  50. Xiao L, Esliger A, Hurley M. Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro. J Bone Miner Res. 2013;28:35-45 pubmed publisher
    ..Our results suggest that phosphate-independent effects of HMW isoforms in vitro may be directly mediated in part via FGF23 and that HMW isoforms signal via FGF23/FGFR/MAPK to inhibit bone formation in vitro. ..
  51. Nowsheen S, Cooper T, Stanley J, Yang E. Synthetic lethal interactions between EGFR and PARP inhibition in human triple negative breast cancer cells. PLoS ONE. 2012;7:e46614 pubmed publisher
    ..Additionally, a contextual synthetic lethality may exist between combined EGFR and PARP inhibitors. ..
  52. Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S. Genome wide array analysis indicates that an amyotrophic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitro. Biochim Biophys Acta. 2013;1832:1129-35 pubmed publisher
    ..It indicates that, despite the obvious cytoplasmic accumulation, FUS-?NLS can act through a nuclear gain of function mechanism. ..
  53. Brudecki L, Ferguson D, McCall C, El Gazzar M. MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes. Immunol Cell Biol. 2013;91:532-40 pubmed publisher
    ..We conclude that miR-146a has a diverse and critical role in limiting an excessive acute inflammatory reaction. ..
  54. Altomare D, Velidandla R, Pirisi L, Creek K. Partial loss of Smad signaling during in vitro progression of HPV16-immortalized human keratinocytes. BMC Cancer. 2013;13:424 pubmed publisher
  55. May V, Buttolph T, Girard B, Clason T, Parsons R. PACAP-induced ERK activation in HEK cells expressing PAC1 receptors involves both receptor internalization and PKC signaling. Am J Physiol Cell Physiol. 2014;306:C1068-79 pubmed publisher
    ..In sum, our results show that PACAP/PAC1 receptor endocytosis and PLC/diacylglycerol/PKC activation represent two complementary mechanisms contributing to PACAP-induced ERK activation. ..
  56. Li W, Li W, Laishram R, Hoque M, Ji Z, Tian B, et al. Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases. Nucleic Acids Res. 2017;45:8930-8942 pubmed publisher
    ..The Star-PAP-mediated APA of PTEN is essential for DNA damage-induced increase of PTEN protein levels. Together, our results reveal a PAS-guided and PAP-mediated paradigm for gene expression in response to cellular signaling cues. ..
  57. Pritchard D, Schubiger G. Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio. Genes Dev. 1996;10:1131-42 pubmed
  58. Shaw L, Lewin A. The Cbp2 protein stimulates the splicing of the omega intron of yeast mitochondria. Nucleic Acids Res. 1997;25:1597-604 pubmed
  59. Gross S, Simerly C, Schatten G, Anderson R. A casein kinase I isoform is required for proper cell cycle progression in the fertilized mouse oocyte. J Cell Sci. 1997;110 ( Pt 24):3083-90 pubmed
    ..These results suggest that the kinase regulates the progression from interphase to mitosis during the first cell cycle. ..
  60. Bokar J, Shambaugh M, Polayes D, Matera A, Rottman F. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA. 1997;3:1233-47 pubmed
    ..MT-A70 also contains a long region of homology to the yeast protein SPO8, which is involved in induction of sporulation by an unknown mechanism. ..
  61. Laughner B, Sehnke P, Ferl R. A novel nuclear member of the thioredoxin superfamily. Plant Physiol. 1998;118:987-96 pubmed
  62. Lavoie H, DeSimone D, Gillio Meina C, Hui Y. Cloning and characterization of porcine ovarian estrogen receptor beta isoforms. Biol Reprod. 2002;66:616-23 pubmed
    ..ER beta is abundant in porcine ovary, and a naturally occurring splice variant missing exon 5 may have biological function. ..
  63. Costantino M, Stearman R, Smith G, Darling D. Cell-specific phosphorylation of Zfhep transcription factor. Biochem Biophys Res Commun. 2002;296:368-73 pubmed
    ..These data provide the first demonstration that Zfhep is post-translationally modified. ..
  64. Li F, Chen J, Solessio E, Gilbert D. Spatial distribution and specification of mammalian replication origins during G1 phase. J Cell Biol. 2003;161:257-66 pubmed
    ..These results highlight two distinct G1 steps that establish a spatial and temporal program for replication. ..
  65. Muresan Z, Muresan V. A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment. Hum Mol Genet. 2004;13:475-88 pubmed
    ..These results suggest that phosphorylated Cgamma accumulates at the SFC. Thus, APP may play a role in pre-mRNA splicing, and Fe65 and APP phosphorylation may regulate this function. ..
  66. Wang M, Qanungo S, Crow M, Watanabe M, Nieminen A. Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei. FEBS Lett. 2005;579:2411-5 pubmed
    ..These findings indicate that ARC is distributed differently in cancer cells than non-cancer cells and thus might play a role in neoplastic transformation. ..
  67. Shimojo M. Characterization of the nuclear targeting signal of REST/NRSF. Neurosci Lett. 2006;398:161-6 pubmed
    ..A point mutation in the zinc finger structure that disrupts its conformation remains nuclear. These data suggest that REST/NRSF contains a NLS around ZFD-5, while the putative NLS at residues 512-522 is non-functional. ..
  68. Hosseinpour F, Timsit Y, Koike C, Matsui K, Yamamoto Y, Moore R, et al. Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver. FEBS Lett. 2007;581:4937-42 pubmed
    ..CAR directly bound to the PH domain. Thus, ECT2 may comprise a part of the PB response signal regulating the intracellular trafficking of CAR. ..
  69. Kelley T, Baz R, Hussein M, Karafa M, Cook J. Clinical significance of cyclin D1, fibroblast growth factor receptor 3, and p53 immunohistochemistry in plasma cell myeloma treated with a thalidomide-based regimen. Hum Pathol. 2009;40:405-12 pubmed publisher
    ..The findings suggest that a thalidomide-based regimen may overcome the poor prognosis associated with a cyclin D1-negative or fibroblast growth factor receptor 3-positive phenotype. ..
  70. Zhang Q, Wang Y. HMG modifications and nuclear function. Biochim Biophys Acta. 2010;1799:28-36 pubmed publisher
    ..In this review, we focus on the chemical modifications of mammalian HMG proteins and highlight their roles in nuclear functions. ..
  71. Sanduja S, Kaza V, Dixon D. The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase. Aging (Albany NY). 2009;1:803-17 pubmed
    ..These findings demonstrate the ability of TTP to act as a tumor suppressor by inhibiting the E6-AP pathway and indicate TTP loss to be a critical event during HPV-mediated carcinogenesis. ..
  72. You S, Zuo L, Varma V. Broad tissue expression of membrane progesterone receptor Alpha in normal mice. J Mol Histol. 2010;41:101-10 pubmed publisher
    ..Our results indicate that mPRalpha may function as a key modulator of P4 in the modulation of multiple physiological functions in normal mice. ..
  73. Hussain S, Gallagher T. SARS-coronavirus protein 6 conformations required to impede protein import into the nucleus. Virus Res. 2010;153:299-304 pubmed publisher
    ..These findings are discussed in the context of the proposed protein 6 structure. ..
  74. Schramp M, Thapa N, Heck J, Anderson R. PIPKI? regulates ?-catenin transcriptional activity downstream of growth factor receptor signaling. Cancer Res. 2011;71:1282-91 pubmed publisher
    ..These results reveal a novel mechanism in which PIPKI? expression and catalytic activity enhance ?-catenin nuclear translocation and expression of its target genes to promote tumorigenic phenotypes. ..
  75. Galbreath K, Cook J, Eddingsaas A, DeChaine E. Diversity and demography in Beringia: multilocus tests of paleodistribution models reveal the complex history of arctic ground squirrels. Evolution. 2011;65:1879-96 pubmed publisher
  76. Burton N, Burkhart K, Kennedy S. Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2011;108:19683-8 pubmed publisher
    ..These results demonstrate that siRNA expression is heritable in C. elegans and define an RNAi pathway that promotes the maintenance of RNAi silencing and siRNA expression in the progeny of animals exposed to dsRNA. ..
  77. Schleit J, Wall V, Simko M, Kaeberlein M. The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans. PLoS ONE. 2011;6:e28036 pubmed publisher
    ..This increased metabolic activation appears to be mediated through the MDT-15 transcription factor and is independent of the IIS pathway. ..
  78. Li Z, Musich P, Serrano M, Dong Z, Zou Y. XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase. PLoS ONE. 2011;6:e28326 pubmed publisher
    ..In contrast, the nuclear import of XPA in G(1) or G(2) phase appears to be largely independent of DNA damage and p53. ..
  79. Karkhanis V, Wang L, Tae S, Hu Y, Imbalzano A, SIF S. Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase ? catalytic subunit gene, POLD1. J Biol Chem. 2012;287:29801-14 pubmed publisher
    ..These results provide evidence for the important role played by PRMT7 in epigenetic regulation of DNA repair genes and cellular response to DNA damage. ..
  80. Bhatnagar A, Unal H, Jagannathan R, Kaveti S, Duan Z, Yong S, et al. Interaction of G-protein ?? complex with chromatin modulates GPCR-dependent gene regulation. PLoS ONE. 2013;8:e52689 pubmed publisher
    ..These findings suggest a wide-ranging mechanism by which direct interaction of G?? with specific chromatin bound transcription factors regulates functional gene networks in response to GPCR activation in cells. ..
  81. Sizemore N, Leung S, Stark G. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol Cell Biol. 1999;19:4798-805 pubmed
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