Genomes and Genes
Experts and Doctors on cell nucleus in Belgium
Topic: cell nucleus
- Vanden Berghe T, Kalai M, Denecker G, Meeus A, Saelens X, Vandenabeele P. Necrosis is associated with IL-6 production but apoptosis is not. Cell Signal. 2006;18:328-35 pubmed..This suggests that the activation of inflammatory pathways is distinct from the activation of necrotic cell death sensu strictu. ..
- De Vos W, Joss G, Haffmans W, Hoebe R, Manders E, Van Oostveldt P. Four-dimensional telomere analysis in recordings of living human cells acquired with controlled light exposure microscopy. J Microsc. 2010;238:254-64 pubmed publisher..With minor modifications, the underlying algorithms can be expanded to the analysis of other intranuclear features, such as nuclear bodies or DNA double stranded break foci. ..
- Verstrepen L, Adib Conquy M, Kreike M, Carpentier I, Adrie C, Cavaillon J, et al. Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB. J Cell Mol Med. 2008;12:316-29 pubmed..Altogether, these data indicate an important role for NF-kappaB-dependent gene expression of ABIN-3 in the negative feedback regulation of TNF receptor and toll-like receptor 4 induced NF-kappaB activation. ..
- Remaut K, Sanders N, Fayazpour F, Demeester J, De Smedt S. Influence of plasmid DNA topology on the transfection properties of DOTAP/DOPE lipoplexes. J Control Release. 2006;115:335-43 pubmed..It seems that, compared to OC and linearized pDNA, SC pDNA is better suited to reach the perinuclear region, a prerequisite to become entrapped in the nuclei of the cells during cell division. ..
- Schouppe D, Ghesquière B, Menschaert G, De Vos W, Bourque S, Trooskens G, et al. Interaction of the tobacco lectin with histone proteins. Plant Physiol. 2011;155:1091-102 pubmed publisher..Since the lectin-histone interaction was shown to be carbohydrate dependent, it is proposed that Nictaba might fulfill a signaling role in response to stress by interacting with O-GlcNAcylated proteins in the plant cell nucleus. ..
- Llorian M, Beullens M, Lesage B, Nicolaescu E, Beke L, Landuyt W, et al. Nucleocytoplasmic shuttling of the splicing factor SIPP1. J Biol Chem. 2005;280:38862-9 pubmed..These findings also have potential implications for a better understanding of the pathogenesis of X-linked mental retardation and polyglutamine-linked neurodegenerative disorders. ..
- Symens N, Walczak R, Demeester J, Mattaj I, De Smedt S, Remaut K. Nuclear inclusion of nontargeted and chromatin-targeted polystyrene beads and plasmid DNA containing nanoparticles. Mol Pharm. 2011;8:1757-66 pubmed publisher..To elucidate if the chromatin binding peptides also have potential in living cells, this additional barrier first has to be tackled, since it prevents free particles from being present near the chromatin at the moment of cell division. ..
- Petta I, Dejager L, Ballegeer M, Lievens S, Tavernier J, De Bosscher K, et al. The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases. Microbiol Mol Biol Rev. 2016;80:495-522 pubmed publisher..Emphasis is placed on the interactions that affect its anti-inflammatory effects in the presence of inflammatory and microbial diseases. ..
- Beullens M, Bollen M. The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly. J Biol Chem. 2002;277:19855-60 pubmed..Our data suggest that NIPP1 can function independently as a splicing factor and a phosphatase regulator. ..
- Rausin G, Tillemans V, Stankovic N, Hanikenne M, Motte P. Dynamic nucleocytoplasmic shuttling of an Arabidopsis SR splicing factor: role of the RNA-binding domains. Plant Physiol. 2010;153:273-84 pubmed publisher..Moreover, our data suggest that CRM1 is a putative export receptor for mRNPs in plants. ..
- Quivy V, Adam E, Collette Y, Demonte D, Chariot A, Vanhulle C, et al. Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies. J Virol. 2002;76:11091-103 pubmed..Therefore, our results open new therapeutic strategies aimed at decreasing or eliminating the pool of latently HIV-infected reservoirs by forcing viral expression. ..
- Van de Sande T, Roskams T, Lerut E, Joniau S, Van Poppel H, Verhoeven G, et al. High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB. J Pathol. 2005;206:214-9 pubmed
- Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J. 2003;22:1313-24 pubmed..This effect represents, together with phosphorylation of nucleosome components such as histone H3, an essential step leading to selective transcriptional activation of NF-kappaB-dependent gene expression. ..
- Icardi L, Lievens S, Mori R, Piessevaux J, De Cauwer L, De Bosscher K, et al. Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2. FASEB J. 2012;26:240-9 pubmed publisher..We conclude that HDAC1 and HDAC2 differentially modulate STAT activity in response to IFN?2: while they are required for the induction of ISGF3-responsive genes, they impair the transcription of STAT3-dependent genes. ..
- Boeynaems S, Bogaert E, Michiels E, Gijselinck I, Sieben A, JoviÄiÄ‡ A, et al. Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD. Sci Rep. 2016;6:20877 pubmed publisher..These findings provide evidence for an important role for nucleocytoplasmic transport in the pathogenic mechanism of c9ALS/FTD. ..
- Lousse J, Van Langendonckt A, Gonzalez Ramos R, Defrere S, Renkin E, Donnez J. Increased activation of nuclear factor-kappa B (NF-kappaB) in isolated peritoneal macrophages of patients with endometriosis. Fertil Steril. 2008;90:217-20 pubmed
- Porceddu A, Stals H, Reichheld J, Segers G, De Veylder L, Barroco R, et al. A plant-specific cyclin-dependent kinase is involved in the control of G2/M progression in plants. J Biol Chem. 2001;276:36354-60 pubmed..These results provide the first evidence that non-PSTAIRE CDKs are involved in the control of the G(2)/M progression in plants. ..
- Pays E, Tebabi P, Pays A, Coquelet H, Revelard P, Salmon D, et al. The genes and transcripts of an antigen gene expression site from T. brucei. Cell. 1989;57:835-45 pubmed..Ultraviolet irradiation, which seems to block RNA processing, allows the tentative mapping of a transcription promoter about 45 kb upstream of the antigen gene...
- Hansenne I, Louis C, Martens H, Dorban G, Charlet Renard C, Peterson P, et al. Aire and Foxp3 expression in a particular microenvironment for T cell differentiation. Neuroimmunomodulation. 2009;16:35-44 pubmed publisher..Aire and Foxp3 are present in the particular TNC microenvironment which has previously been shown to support thymic selection. The differential localization of these two markers suggests a role for TNC in nTreg development. ..
- Maertens G, Cherepanov P, Pluymers W, Busschots K, De Clercq E, Debyser Z, et al. LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J Biol Chem. 2003;278:33528-39 pubmed..We conclude, therefore, that the interaction with LEDGF/p75 accounts for the karyophilic properties and chromosomal targeting of HIV-1 IN. ..
- Rothé F, Gueydan C, Bellefroid E, Huez G, Kruys V. Identification of FUSE-binding proteins as interacting partners of TIA proteins. Biochem Biophys Res Commun. 2006;343:57-68 pubmed..Together, our results indicate that TIA and FBP proteins may thus be relevant biological involved in common events of RNA metabolism occurring both in the nucleus and the cytoplasm. ..
- Frédérich B, Sorenson L, Santini F, Slater G, Alfaro M. Iterative ecological radiation and convergence during the evolutionary history of damselfishes (Pomacentridae). Am Nat. 2013;181:94-113 pubmed publisher..Through the Pomacentridae, we illustrate that radiations may be strongly structured by the nature of the constraints on diversification. ..
- Ding H, Descheemaeker K, Marynen P, Nelles L, Carvalho T, Carmo Fonseca M, et al. Characterization of a helicase-like transcription factor involved in the expression of the human plasminogen activator inhibitor-1 gene. DNA Cell Biol. 1996;15:429-42 pubmed..Mutation of the PAI-1 B Box led to an eight-fold reduction of basal PAI-1-LUC expression in these cell lines, but did not affect the four- to six-fold induction by phorbol esters. ..
- Petit M, Fradelizi J, Golsteyn R, Ayoubi T, Menichi B, Louvard D, et al. LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. Mol Biol Cell. 2000;11:117-29 pubmed..Altogether, these results show that the LPP protein has multifunctional domains and may serve as a scaffold upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. ..
- Georis I, Tate J, Feller A, Cooper T, Dubois E. Intranuclear function for protein phosphatase 2A: Pph21 and Pph22 are required for rapamycin-induced GATA factor binding to the DAL5 promoter in yeast. Mol Cell Biol. 2011;31:92-104 pubmed publisher..e., ure2? is epistatic to pph21? pph22?. This final observation adds additional support to our previous conclusion that the Gln3 and Gat1 GATA factor localizations are predominantly controlled by different regulatory pathways. ..
- Montague K, Lowe A, Uzquiano A, Knüfer A, Astick M, Price S, et al. The assembly of developing motor neurons depends on an interplay between spontaneous activity, type II cadherins and gap junctions. Development. 2017;144:830-836 pubmed publisher..Our study suggests that a network of interactions between cadherins, gap junctions and spontaneous activity governs neuron assembly, presaging circuit formation. ..
- Renouf S, Beullens M, Wera S, Van Eynde A, Sikela J, Stalmans W, et al. Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1. FEBS Lett. 1995;375:75-8 pubmed..Northern analysis revealed a major transcript of 1.39 kb in all 8 investigated human tissues. sds22 was detected by western analysis in both the cytoplasm and the nucleus of rat liver cells as a polypeptide of 44 kDa. ..
- Dieriks B, Van Oostveldt P. Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription. Int J Mol Med. 2012;29:1031-8 pubmed publisher..Supported by in silico data, our observations suggest that CypB interacts with these proteins and is involved in ribosome biogenesis and RNA transcription. ..
- Maes B, Demunter A, Peeters B, De Wolf Peeters C. BCL10 mutation does not represent an important pathogenic mechanism in gastric MALT-type lymphoma, and the presence of the API2-MLT fusion is associated with aberrant nuclear BCL10 expression. Blood. 2002;99:1398-404 pubmed..In contrast, they indicate that the presence of the API2-MLT fusion protein is associated with aberrant nuclear BCL10 expression. ..
- van Hengel J, Vanhoenacker P, Staes K, van Roy F. Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression. Proc Natl Acad Sci U S A. 1999;96:7980-5 pubmed..These results reveal molecular mechanisms controlling the subcellular distribution of p120(ctn). ..
- el Alami M, Feller A, Pierard A, Dubois E. Characterisation of a tripartite nuclear localisation sequence in the regulatory protein Lys14 of Saccharomyces cerevisiae. Curr Genet. 2000;38:78-86 pubmed..Simultaneous mutations in the three basic domains are required to completely abolish the entry into the nucleus and to impair the Lys14 function. ..
- Lesage B, Beullens M, Pedelini L, Garcia Gimeno M, Waelkens E, Sanz P, et al. A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. Biochemistry. 2007;46:8909-19 pubmed..Therefore, our studies show that a pool of PP1 is complexly controlled by both Sds22 and I3. ..
- Twyffels L, Gueydan C, Kruys V. Transportin-1 and Transportin-2: protein nuclear import and beyond. FEBS Lett. 2014;588:1857-68 pubmed publisher..Besides, new functions of Transportin-1 are emerging in processes other than nuclear import. Here, we summarize what is known about Transportin-1 and the related ?-karyopherin Transportin-2. ..
- Kushnir S, Babiychuk E, Storozhenko S, Davey M, Papenbrock J, De Rycke R, et al. A mutation of the mitochondrial ABC transporter Sta1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik. Plant Cell. 2001;13:89-100 pubmed..Taken together, our results suggest that plant mitochondria possess an evolutionarily conserved Fe/S cluster biosynthesis pathway, which is linked to the intracellular iron homeostasis by the function of Atm1p-like ABC transporters. ..
- Hav M, Lem D, Chhut S, Kong R, Pauwels P, Cuvelier C, et al. Clear-cell variant of solid-pseudopapillary neoplasm of the pancreas: a case report and review of the literature. Malays J Pathol. 2009;31:137-41 pubmed..Although a rare neoplasm, it is important to recognize this entity for appropriate management...
- Ote I, Piette J, Sadzot Delvaux C. The Varicella-Zoster virus IE4 protein: a conserved member of the herpesviral mRNA export factors family and a potential alternative target in antiherpetic therapies. Biochem Pharmacol. 2010;80:1973-80 pubmed publisher..Here, we discussed the possibility of developing antiherpetic agents targeting IE4 or its herpesviral homologues. ..
- Bogaerts S, Vanlandschoot A, van Hengel J, van Roy F. Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. Exp Cell Res. 2005;311:1-13 pubmed..The interaction and nuclear cotranslocation of a neural alpha-catenin with a putative proto-oncogene product as reported here provides novel insights into the signaling functions of alpha-catenins. ..
- Georis I, Tate J, Cooper T, Dubois E. Nitrogen-responsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by rapamycin and the other by methionine sulfoximine. J Biol Chem. 2011;286:44897-912 pubmed publisher..Collectively, our data support the existence of two different nitrogen-responsive regulatory pathways, one inhibited by Msx and the other by rapamycin. ..
- Van Impe K, De Corte V, Eichinger L, Bruyneel E, Mareel M, Vandekerckhove J, et al. The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins. J Biol Chem. 2003;278:17945-52 pubmed..Our findings explain regulated subcellular targeting of distinct classes of actin-binding proteins. ..
- Van Hove J, Fouquaert E, Smith D, Proost P, Van Damme E. Lectin activity of the nucleocytoplasmic EUL protein from Arabidopsis thaliana. Biochem Biophys Res Commun. 2011;414:101-5 pubmed publisher..Despite the high sequence identity between the EUL domains in EEA and ArathEULS3, both domains recognize different carbohydrate structures. ..
- Banmeyer I, Marchand C, Verhaeghe C, Vucic B, Rees J, Knoops B. Overexpression of human peroxiredoxin 5 in subcellular compartments of Chinese hamster ovary cells: effects on cytotoxicity and DNA damage caused by peroxides. Free Radic Biol Med. 2004;36:65-77 pubmed
- Lesage B, Beullens M, Nuytten M, Van Eynde A, Keppens S, Himpens B, et al. Interactor-mediated nuclear translocation and retention of protein phosphatase-1. J Biol Chem. 2004;279:55978-84 pubmed..Our data suggest that both the nuclear translocation and the nuclear retention of PP1 depend on its binding to interactors with an RVXF motif. ..
- Stankovic N, Schloesser M, Joris M, Sauvage E, Hanikenne M, Motte P. Dynamic Distribution and Interaction of the Arabidopsis SRSF1 Subfamily Splicing Factors. Plant Physiol. 2016;170:1000-13 pubmed publisher..Altogether, our report extends our understanding of shuttling dynamics of Arabidopsis SR splicing factors. ..
- Tillemans V, Leponce I, Rausin G, Dispa L, Motte P. Insights into nuclear organization in plants as revealed by the dynamic distribution of Arabidopsis SR splicing factors. Plant Cell. 2006;18:3218-34 pubmed..Our findings emphasize the high mobility of Arabidopsis SR splicing factors and provide insights into the dynamic relationships between the different nuclear compartments. ..
- Reuse S, Calao M, Kabeya K, Guiguen A, Gatot J, Quivy V, et al. Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection. PLoS ONE. 2009;4:e6093 pubmed publisher..Our results suggest that combinations of different kinds of proviral activators may have important implications for reducing the size of latent HIV-1 reservoirs in HAART-treated patients. ..
- De Vos W, van Neste L, Dieriks B, Joss G, Van Oostveldt P. High content image cytometry in the context of subnuclear organization. Cytometry A. 2010;77:64-75 pubmed publisher..Consequently, this type of nuclear fingerprinting shows potential for high-throughput applications, such as functional protein assays or drug compound screening. ..
- Coulonval K, Kooken H, Roger P. Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation. Mol Biol Cell. 2011;22:3971-85 pubmed publisher..This explained the opposite effects of reduced expression of Myt1 and Wee1, with only the latter inducing catastrophic mitoses. ..
- Foury F. Cloning and sequencing of the nuclear gene MIP1 encoding the catalytic subunit of the yeast mitochondrial DNA polymerase. J Biol Chem. 1989;264:20552-60 pubmed..4) The MIP1 protein exhibits sequence similarities with both eukaryotic nuclear DNA polymerases and reverse transcriptases. There is no significant resemblance with prokaryotic DNA polymerases. ..
- Bercy J, Dubois E, Messenguy F. Regulation of arginine metabolism in Saccharomyces cerevisiae: expression of the three ARGR regulatory genes and cellular localization of their products. Gene. 1987;55:277-85 pubmed..However, some data suggest that the ARGRIII protein could control ARGRI activity. ..
- Bonne S, van Hengel J, Nollet F, Kools P, van Roy F. Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells. J Cell Sci. 1999;112 ( Pt 14):2265-76 pubmed..Furthermore, the human plakophilin-3 gene was mapped on the chromosomal locus 11p15 by fluorescent in situ hybridization. ..
- Cassens I, Vicario S, Waddell V, Balchowsky H, Van Belle D, Ding W, et al. Independent adaptation to riverine habitats allowed survival of ancient cetacean lineages. Proc Natl Acad Sci U S A. 2000;97:11343-7 pubmed
- Braem C, Kas K, Meyen E, Debiec Rychter M, Van de Ven W, Voz M. Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal. J Biol Chem. 2002;277:19673-8 pubmed..These observations indicate that the nuclear import of PLAG1 is governed by its zinc finger domain and by NLS1, a karyopherin alpha2 recognition site. ..
- Gilles C, Polette M, Mestdagt M, Nawrocki Raby B, Ruggeri P, Birembaut P, et al. Transactivation of vimentin by beta-catenin in human breast cancer cells. Cancer Res. 2003;63:2658-64 pubmed..Our results therefore demonstrate that the vimentin promoter is a target of the beta-catenin/TCF pathway and strongly suggest an implication of this regulation in epithelial cell migration/invasion. ..
- Fouquaert E, Hanton S, Brandizzi F, Peumans W, Van Damme E. Localization and topogenesis studies of cytoplasmic and vacuolar homologs of the Galanthus nivalis agglutinin. Plant Cell Physiol. 2007;48:1010-21 pubmed
- Van Coster R, Seneca S, Smet J, Van Hecke R, Gerlo E, Devreese B, et al. Homozygous Gly555Glu mutation in the nuclear-encoded 70 kDa flavoprotein gene causes instability of the respiratory chain complex II. Am J Med Genet A. 2003;120A:13-8 pubmed..This observation prompts speculation of a labile interaction between Ip and Fp polypeptides and of a key role of the amino acid at position 555 in the interacting domain. ..
- Torres Acosta J, de Almeida Engler J, Raes J, Magyar Z, De Groodt R, Inze D, et al. Molecular characterization of Arabidopsis PHO80-like proteins, a novel class of CDKA;1-interacting cyclins. Cell Mol Life Sci. 2004;61:1485-97 pubmed..The possible role of CYCPs in linking cell division, cell differentiation, and the nutritional status of the cell is discussed. ..
- Donnay I, Faerge I, Grøndahl C, Verhaeghe B, Sayoud H, Ponderato N, et al. Effect of prematuration, meiosis activating sterol and enriched maturation medium on the nuclear maturation and competence to development of calf oocytes. Theriogenology. 2004;62:1093-107 pubmed..However, enriching the maturation medium had a positive effect on embryo development, indicating that cytoplasmic maturation was improved. ..
- Van Impe K, Hubert T, De Corte V, Vanloo B, Boucherie C, Vandekerckhove J, et al. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. Traffic. 2008;9:695-707 pubmed publisher..Thus, a ubiquitously expressed protein shuttles to the nucleus through direct association with NTF2 and Ran. The role of NTF2 may therefore not be solely confined to sustaining the Ran gradient in cells. ..
- Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, et al. The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J Cell Biol. 1999;145:1471-82 pubmed
- Verschueren K, Huylebroeck D. Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells. Cytokine Growth Factor Rev. 1999;10:187-99 pubmed..We summarize some of the most recent data with regard to this aspect in this rapidly advancing field. ..
- Weyn B, Jacob W, da Silva V, Montironi R, Hamilton P, Thompson D, et al. Data representation and reduction for chromatin texture in nuclei from premalignant prostatic, esophageal, and colonic lesions. Cytometry. 2000;41:133-8 pubmed..Image analysis and subsequent data reduction of nuclear signatures of contour features is a novel method, providing quantitative information that may lead to an effective identification of nuclei and lesions. ..
- Tillemans V, Dispa L, Remacle C, Collinge M, Motte P. Functional distribution and dynamics of Arabidopsis SR splicing factors in living plant cells. Plant J. 2005;41:567-82 pubmed..SR proteins also localized within small foci at anaphase. These results demonstrate interesting related features as well as potentially important differences between plant and animal SR proteins. ..
- Zhang T, Delestienne N, Huez G, Kruys V, Gueydan C. Identification of the sequence determinants mediating the nucleo-cytoplasmic shuttling of TIAR and TIA-1 RNA-binding proteins. J Cell Sci. 2005;118:5453-63 pubmed..This study demonstrates the importance of TIAR and TIA-1 RNA-binding domains for their subcellular localization and provides the first evidence for distinct functions of TIAR and TIA-1 RRMs. ..
- Maes M, Mihaylova I, Bosmans E. Not in the mind of neurasthenic lazybones but in the cell nucleus: patients with chronic fatigue syndrome have increased production of nuclear factor kappa beta. Neuro Endocrinol Lett. 2007;28:456-62 pubmed..It is suggested that CFS patients should be treated with antioxidants, which inhibit the production of NFkappabeta, such as curcumin, N-Acetyl-Cysteine, quercitin, silimarin, lipoic acid and omega-3 fatty acids. ..
- De Leeuw F, Zhang T, Wauquier C, Huez G, Kruys V, Gueydan C. The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor. Exp Cell Res. 2007;313:4130-44 pubmed..Altogether, our findings further reveal the diversity of mechanisms by which CIRP is regulated by environmental stresses and provide new insights into CIRP cytoplasmic function. ..
- Longin S, Zwaenepoel K, Martens E, Louis J, Rondelez E, Goris J, et al. Spatial control of protein phosphatase 2A (de)methylation. Exp Cell Res. 2008;314:68-81 pubmed..PME-1 associates with an inactive PP2A population, regardless of its esterase activity or localization. We propose that stabilization of this inactive, nuclear PP2A pool is a major in vivo function of PME-1. ..
- Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss K, et al. ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. J Biol Chem. 2009;284:11738-47 pubmed publisher..Thus, ADAM10 performs a dual role in cells, as a metalloprotease when it is membrane-bound, and as a potential signaling protein once cleaved by ADAM9/15 and the gamma-Secretase. ..
- Jacoby M, Cox J, Gayral S, Hampshire D, Ayub M, Blockmans M, et al. INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Nat Genet. 2009;41:1027-31 pubmed publisher..Together, our results show that INPP5E plays an essential role in the primary cilium by controlling ciliary growth factor and PI3K signaling and stability, and highlight the consequences of INPP5E dysfunction. ..
- Gloire G, Horion J, El Mjiyad N, Bex F, Chariot A, Dejardin E, et al. Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding. J Biol Chem. 2007;282:21308-18 pubmed..We conclude that nuclear IKKalpha is required for p65 DNA binding in a gene-specific manner. ..
- Desmidt M, Ducatelle R, Uyttebroek E, Charlier G, Hoorens J. Respiratory adenovirus-like infection in a rose-ringed parakeet (Psittacula krameri). Avian Dis. 1991;35:1001-6 pubmed..Transmission electron microscopy revealed the presence of numerous particles of adenovirus morphology. A latent adenovirus infection may have become more severe following chlamydiosis and the stress of handling...
- Reveillaud J, Remerie T, Van Soest R, Erpenbeck D, Cárdenas P, Derycke S, et al. Species boundaries and phylogenetic relationships between Atlanto-Mediterranean shallow-water and deep-sea coral associated Hexadella species (Porifera, Ianthellidae). Mol Phylogenet Evol. 2010;56:104-14 pubmed publisher..cf. dedritifera and H. pruvoti from the Mediterranean Sea was observed. All Hexadella racovitzai specimens from the Mediterranean Sea (shallow and deep) to the Atlantic formed a monophyletic group...
- Vermassen E, Van Acker K, Annaert W, Himpens B, Callewaert G, Missiaen L, et al. Microtubule-dependent redistribution of the type-1 inositol 1,4,5-trisphosphate receptor in A7r5 smooth muscle cells. J Cell Sci. 2003;116:1269-77 pubmed..Taken together, these findings suggest a role for protein kinase C and microtubuli in the redistribution of IP(3)R1, which probably occurs via a mechanism of vesicular trafficking. ..
- Badran B, Wolinsky S, Burny A, Willard Gallo K. Identification of three NFAT binding motifs in the 5'-upstream region of the human CD3gamma gene that differentially bind NFATc1, NFATc2, and NF-kappa B p50. J Biol Chem. 2002;277:47136-48 pubmed..Finally, we have shown that an increase in the binding of nuclear NFATc2, NFATc1, and NF-kappaB p50 to these three motifs is correlated with a progressive loss of CD3gamma transcripts after HIV-1 infection. ..
- Lamsoul I, Lodewick J, Lebrun S, Brasseur R, Burny A, Gaynor R, et al. Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein. Mol Cell Biol. 2005;25:10391-406 pubmed..These modifications may result in targets for the treatment of adult T-cell leukemia. ..
- Storozhenko S, Inze D, Van Montagu M, Kushnir S. Arabidopsis coactivator ALY-like proteins, DIP1 and DIP2, interact physically with the DNA-binding domain of the Zn-finger poly(ADP-ribose) polymerase. J Exp Bot. 2001;52:1375-80 pubmed..Their homology to the transcriptional coactivator ALY suggests that plant PARP may play a role in the regulation of transcription. ..
- Boudolf V, Lammens T, Boruc J, Van Leene J, Van Den Daele H, Maes S, et al. CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset. Plant Physiol. 2009;150:1482-93 pubmed publisher..We conclude that CCS52A1 participates in endocycle onset by down-regulating CDKB1;1 activity through the destruction of CYCA2;3. ..
- Janssens S, Knox E, Huysmans S, Smets E, Merckx V. Rapid radiation of Impatiens (Balsaminaceae) during Pliocene and Pleistocene: result of a global climate change. Mol Phylogenet Evol. 2009;52:806-24 pubmed publisher..Without this accelerated diversification rate, Impatiens would only have contained 1/5th of its current number of species, thereby indicating the rapid radiation of the genus...
- Verbakel W, Carmeliet G, Engelborghs Y. SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction. Biochem Biophys Res Commun. 2011;411:732-7 pubmed publisher..Interphase NuSAP-chromatin interaction suggests additional functions for NuSAP, as recently identified for other nuclear spindle assembly factors with a role in gene expression or DNA damage response. ..
- De Corte V, Van Impe K, Bruyneel E, Boucherie C, Mareel M, Vandekerckhove J, et al. Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion. J Cell Sci. 2004;117:5283-92 pubmed..We show for the first time active nuclear import of an actin binding protein, and our findings point to a role for nuclear CapG in eliciting invasion, possibly through interfering with the cellular transcription machinery. ..
- Coene E, Hollinshead M, Waeytens A, Schelfhout V, Eechaute W, Shaw M, et al. Phosphorylated BRCA1 is predominantly located in the nucleus and mitochondria. Mol Biol Cell. 2005;16:997-1010 pubmed..Because phosphorylation of BRCA1 and subsequent changes in subcellular localization are known to follow DNA damage, our data support a universal role for BRCA1 in the maintenance of genome integrity in both mitochondria and nucleus. ..
- Poncelet D, Bellefroid E, Bastiaens P, Demoitie M, Marine J, Pendeville H, et al. Functional analysis of ZNF85 KRAB zinc finger protein, a member of the highly homologous ZNF91 family. DNA Cell Biol. 1998;17:931-43 pubmed..The ZNF85 KRAB(A) and (B) domains in vitro bound several nuclear proteins that might constitute critical cofactors for repression. ..