Experts and Doctors on cell movement in Belgium


Locale: Belgium
Topic: cell movement

Top Publications

  1. Mertens A, Verhamme P, Bielicki J, Phillips M, Quarck R, Verreth W, et al. Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis. Circulation. 2003;107:1640-6 pubmed
    ..Transient LCAT overexpression was associated with a reduction of oxidative stress and atherosclerosis. ..
  2. Jacobs K, Feys L, Vanhoecke B, Van Marck V, Bracke M. P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice. Eur J Cancer Prev. 2011;20:207-16 pubmed publisher
    ..Therefore, P-cadherin can be considered as a potential therapeutic target in the treatment of melanoma. ..
  3. Stamatopoulos B, Meuleman N, De Bruyn C, Pieters K, Mineur P, Le Roy C, et al. AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments. Haematologica. 2012;97:608-15 pubmed publisher
    ..Combining AMD3100 with other drugs may, therefore, represent a promising therapeutic approach to kill chronic lymphocytic leukemia cells. ..
  4. Bauters D, Van Hul M, Lijnen H. Macrophage elastase (MMP-12) in expanding murine adipose tissue. Biochim Biophys Acta. 2013;1830:2954-9 pubmed publisher
    ..MMP-12 does not seem to be essential for macrophage infiltration in adipose tissue, but contributes to the formation of CLS surrounding moribund adipocytes. ..
  5. De Cat B, Muyldermans S, Coomans C, Degeest G, Vanderschueren B, Creemers J, et al. Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. J Cell Biol. 2003;163:625-35 pubmed
  6. Berndt S, Blacher S, Perrier d Hauterive S, Thiry M, Tsampalas M, Cruz A, et al. Chorionic gonadotropin stimulation of angiogenesis and pericyte recruitment. J Clin Endocrinol Metab. 2009;94:4567-74 pubmed publisher
    ..Our findings highlight a novel paracrine role of this early embryonic signal in vessel maturation by stimulating perivascular cell recruitment, migration, and proliferation. ..
  7. Pyr dit Ruys S, Delaive E, Demazy C, Dieu M, Raes M, Michiels C. Identification of DH IC-2 as a HIF-1 independent protein involved in the adaptive response to hypoxia in tumor cells: A putative role in metastasis. Biochim Biophys Acta. 2009;1793:1676-90 pubmed publisher
    ..These results are important to better understand cancer development since they highlight a HIF-1 independent mechanism, which may be involved in metastasis. ..
  8. Soenen S, De Meyer S, Dresselaers T, Vande Velde G, Pareyn I, Braeckmans K, et al. MRI assessment of blood outgrowth endothelial cell homing using cationic magnetoliposomes. Biomaterials. 2011;32:4140-50 pubmed publisher
    ..In particular, the use of these MLs will allow to evaluate the efficacy of new methods to enhance BOEC homing and integration to optimize their use as efficient vehicles for gene therapy. ..
  9. Gueders M, Balbin M, Rocks N, Foidart J, Gosset P, Louis R, et al. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol. 2005;175:2589-97 pubmed

More Information

Publications102 found, 100 shown here

  1. Mortier A, Van Damme J, Proost P. Regulation of chemokine activity by posttranslational modification. Pharmacol Ther. 2008;120:197-217 pubmed publisher
    ..This report reviews current understanding on the regulation of the chemokine network through posttranslational modification and its consequences for leukocyte migration, angiogenesis and protection against viral infection. ..
  2. Gils A, Declerck P. The structural basis for the pathophysiological relevance of PAI-I in cardiovascular diseases and the development of potential PAI-I inhibitors. Thromb Haemost. 2004;91:425-37 pubmed
  3. Buytaert E, Matroule J, Durinck S, Close P, Kocanova S, Vandenheede J, et al. Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells. Oncogene. 2008;27:1916-29 pubmed
    ..This analysis identifies new molecular effectors of the cancer cell response to PDT opening attractive avenues to improve the therapeutic efficacy of hypericin-based PDT of bladder cancer. ..
  4. Le Moine A, Surquin M, Demoor F, Noel J, Nahori M, Pretolani M, et al. IL-5 mediates eosinophilic rejection of MHC class II-disparate skin allografts in mice. J Immunol. 1999;163:3778-84 pubmed
    ..We conclude that MHC class II-disparate skin allografts trigger an IL-5-dependent infiltration of eosinophils that is sufficient to result in acute graft destruction. ..
  5. Ingrassia L, Nshimyumukiza P, Dewelle J, Lefranc F, Wlodarczak L, Thomas S, et al. A lactosylated steroid contributes in vivo therapeutic benefits in experimental models of mouse lymphoma and human glioblastoma. J Med Chem. 2006;49:1800-7 pubmed
    ..This compound also increased the survival of immunodeficient mice into whose brains human U373 glioblastoma cells had been orthotopically grafted. ..
  6. Detry B, Bruyére F, Erpicum C, Paupert J, Lamaye F, Maillard C, et al. Digging deeper into lymphatic vessel formation in vitro and in vivo. BMC Cell Biol. 2011;12:29 pubmed publisher
    ..In addition, our data emphasize the suitability of the lymphatic ring assay to unravel mechanisms underlying lymphangiogenesis. ..
  7. Armacki M, Joodi G, Nimmagadda S, De Kimpe L, Pusapati G, Vandoninck S, et al. A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis. Oncogene. 2014;33:1167-80 pubmed publisher
    ..Thus, CIB1a is a novel mediator of PKD2-driven carcinogenesis and a potentially interesting therapeutic target. ..
  8. Billiau A, Roskams T, Van Damme Lombaerts R, Matthys P, Wouters C. Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-gamma-producing lymphocytes and IL-6- and TNF-alpha-producing macrophages. Blood. 2005;105:1648-51 pubmed
  9. Lamour V, Le Mercier M, Lefranc F, Hagedorn M, Javerzat S, Bikfalvi A, et al. Selective osteopontin knockdown exerts anti-tumoral activity in a human glioblastoma model. Int J Cancer. 2010;126:1797-1805 pubmed publisher
    ..This is the first demonstration that OPN inhibition blocks glioma tumor growth, making this invasion-related protein an attractive target for glioma therapy. ..
  10. Braun D, Rao J, Mollet G, Schapiro D, Daugeron M, Tan W, et al. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Nat Genet. 2017;49:1529-1538 pubmed publisher
    ..We thus identified four new monogenic causes of GAMOS, describe a link between KEOPS function and human disease, and delineate potential pathogenic mechanisms. ..
  11. Sinnaeve P, Chiche J, Nong Z, Varenne O, Van Pelt N, Gillijns H, et al. Soluble guanylate cyclase alpha(1) and beta(1) gene transfer increases NO responsiveness and reduces neointima formation after balloon injury in rats via antiproliferative and antimigratory effects. Circ Res. 2001;88:103-9 pubmed
    ..05). Thus, Adalpha1 and Adbeta1 gene transfer to balloon-injured rat carotid arteries increases NO responsiveness and attenuates neointima formation via a direct antiproliferative and antimigratory effect on vascular smooth muscle cells. ..
  12. Smits K, Iannucci V, Stove V, Van Hauwe P, Naessens E, Meuwissen P, et al. Rho GTPase Cdc42 is essential for human T-cell development. Haematologica. 2010;95:367-75 pubmed publisher
    ..Our data suggest that enhanced apoptotic death and reduced proliferation rather than disturbed migration explains the decreased thymopoiesis induced by dominant negative Cdc42. ..
  13. Sonveaux P, Brouet A, Havaux X, Gregoire V, Dessy C, Balligand J, et al. Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy. Cancer Res. 2003;63:1012-9 pubmed
    ..Moreover, our demonstration that the inhibition of NO production suppresses these provascular effects of irradiation highlights new potentials for the coordinated use of antiangiogenic strategies and radiotherapy in clinical practice. ..
  14. De Smet F, Segura I, De Bock K, Hohensinner P, Carmeliet P. Mechanisms of vessel branching: filopodia on endothelial tip cells lead the way. Arterioscler Thromb Vasc Biol. 2009;29:639-49 pubmed publisher
    ..Here, we will discuss the molecular candidates that participate in the decision of endothelial cells to adapt these distinct fates and highlight the emerging insights on how these cells send out filopodia while navigating. ..
  15. Van Audenhove I, Boucherie C, Pieters L, Zwaenepoel O, Vanloo B, Martens E, et al. Stratifying fascin and cortactin function in invadopodium formation using inhibitory nanobodies and targeted subcellular delocalization. FASEB J. 2014;28:1805-18 pubmed publisher
    ..Hence, we demonstrate that nanobodies enable high resolution protein function mapping in cells. ..
  16. Vriens J, Janssens A, Prenen J, Nilius B, Wondergem R. TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells. Cell Calcium. 2004;36:19-28 pubmed
    ..HGF/SF increases Ca(2+) entry via TRPV1, but not via TRPV4. This rise in [Ca(2+)](i) may constitute an early response of a signalling cascade that gives rise to cell locomotion and the migratory phenotype. ..
  17. De Spiegelaere W, Casteleyn C, van den Broeck W, Plendl J, Bahramsoltani M, Simoens P, et al. Intussusceptive angiogenesis: a biologically relevant form of angiogenesis. J Vasc Res. 2012;49:390-404 pubmed publisher
    ..Here, the mechanism of intussusceptive angiogenesis is reviewed and the current techniques and models for investigating intussusceptive angiogenesis are summarized. In addition, other mechanisms of vascular growth are briefly reviewed. ..
  18. Masuzzo P, Van Troys M, Ampe C, Martens L. Taking Aim at Moving Targets in Computational Cell Migration. Trends Cell Biol. 2016;26:88-110 pubmed publisher
    ..Finally, we provide a list of available software tools for cell migration to assist researchers in choosing the most appropriate solution for their needs. ..
  19. Devy L, Hollender P, Munaut C, Colige A, Garnotel R, Foidart J, et al. Matrix and serine protease expression during leukemic cell differentiation induced by aclacinomycin and all-trans-retinoic acid. Biochem Pharmacol. 2002;63:179-89 pubmed
  20. Verhoelst C, Darras V, Doulabi B, Reyns G, Kuhn E, Van der Geyten S. Type I iodothyronine deiodinase in euthyroid and hypothyroid chicken cerebellum. Mol Cell Endocrinol. 2004;214:97-105 pubmed
  21. Martens L, Monsieur G, Ampe C, Gevaert K, Vandekerckhove J. Cell_motility: a cross-platform, open source application for the study of cell motion paths. BMC Bioinformatics. 2006;7:289 pubmed
  22. Drennan M, Elewaut D, Hogquist K. Thymic emigration: sphingosine-1-phosphate receptor-1-dependent models and beyond. Eur J Immunol. 2009;39:925-30 pubmed publisher
  23. Liu Z, Van Rossen E, Timmermans J, Geerts A, van Grunsven L, Reynaert H. Distinct roles for non-muscle myosin II isoforms in mouse hepatic stellate cells. J Hepatol. 2011;54:132-41 pubmed publisher
    ..In mouse HSCs, myosin IIA and IIB clearly fulfil distinct roles. Our results provide an insight into the contractile machinery of HSCs, that could be important in the search for new molecules to treat portal hypertension. ..
  24. Mortier S, De Vriese A, McLoughlin R, Topley N, Schaub T, Passlick Deetjen J, et al. Effects of conventional and new peritoneal dialysis fluids on leukocyte recruitment in the rat peritoneal membrane. J Am Soc Nephrol. 2003;14:1296-306 pubmed
    ..Bicarbonate-buffered pH-neutral PDF with low GDP contents have fewer depressant effects and may therefore contribute to a better preservation of peritoneal host defense. ..
  25. Lambrechts A, Gevaert K, Cossart P, Vandekerckhove J, Van Troys M. Listeria comet tails: the actin-based motility machinery at work. Trends Cell Biol. 2008;18:220-7 pubmed publisher
    ..In this review, we discuss current models of pseudopodial protrusions and describe how the road to more complex models lies open and is already paved by recent studies using Listeria-based biomimetic motility assays. ..
  26. Soenen S, Manshian B, Montenegro J, Amin F, Meermann B, Thiron T, et al. Cytotoxic effects of gold nanoparticles: a multiparametric study. ACS Nano. 2012;6:5767-83 pubmed publisher
  27. Wayteck L, Dewitte H, De Backer L, Breckpot K, Demeester J, De Smedt S, et al. Hitchhiking nanoparticles: Reversible coupling of lipid-based nanoparticles to cytotoxic T lymphocytes. Biomaterials. 2016;77:243-54 pubmed publisher
    ..Based on this optimization using liposomes as model NPs, a small interfering RNA (siRNA)-loaded NP was developed that can be coupled to the surface of CD8(+) T cells. ..
  28. Soenen S, Himmelreich U, Nuytten N, De Cuyper M. Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling. Biomaterials. 2011;32:195-205 pubmed publisher
    ..These results highlight the importance of in-depth cytotoxic evaluation of cell labelling studies as at non-toxic concentrations, some particles appear to be less suitable for the MR visualization of labelled cells. ..
  29. Sylvie J, Ellen C, Kris V. The role of Wnt in cell signaling and cell adhesion during early vertebrate development. Front Biosci (Landmark Ed). 2011;16:2352-66 pubmed
    ..In this review, we will focus on how Wnt signaling cooperates with cell adhesion to ensure smooth processing of gastrulation, somitogenesis and neurulation. ..
  30. Cardoso A, Pinto M, Pinto A, Oliveira M, Pinto M, Goncalves R, et al. Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity. Oncogene. 2014;33:2123-33 pubmed publisher
  31. Lantoine J, Grevesse T, Villers A, Delhaye G, Mestdagh C, Versaevel M, et al. Matrix stiffness modulates formation and activity of neuronal networks of controlled architectures. Biomaterials. 2016;89:14-24 pubmed publisher
  32. Meerschaert K, Bruyneel E, De Wever O, Vanloo B, Boucherie C, Bracke M, et al. The tandem PDZ domains of syntenin promote cell invasion. Exp Cell Res. 2007;313:1790-804 pubmed
  33. De Ganck A, De Corte V, Bruyneel E, Bracke M, Vandekerckhove J, Gettemans J. Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells. Int J Oncol. 2009;34:1403-9 pubmed
    ..While these findings are at variance with the suggested tumor suppressor role for myopodin, we hypothesize that the subcellular localization of the protein is involved in its suppressor or activator function in tumorigenesis. ..
  34. Dhaenens M, Fert I, Glatigny S, Haerinck S, Poulain C, Donnadieu E, et al. Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics, class II major histocompatibility complex expression, and viability. Arthritis Rheum. 2009;60:2622-32 pubmed publisher
    ..The present study was undertaken to investigate several characteristics of mature dendritic cells (DCs), which are believed to be essential for triggering disease in a model of SpA in HLA-B27-transgenic rats...
  35. Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui Artola A, Kim D, et al. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A. 2012;109:12449-54 pubmed publisher
  36. Elong Edimo W, Ghosh S, Derua R, Janssens V, Waelkens E, Vanderwinden J, et al. SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma cells. J Cell Sci. 2016;129:1101-14 pubmed publisher
    ..Thus, our results reveal a new role of SHIP2 in the control of PI(4,5)P2, PI4P and cell migration in PTEN-deficient glioblastoma 1321 N1 cells. ..
  37. Moons L, Shi C, Ploplis V, Plow E, Haber E, Collen D, et al. Reduced transplant arteriosclerosis in plasminogen-deficient mice. J Clin Invest. 1998;102:1788-97 pubmed
  38. Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell. 2001;7:1267-78 pubmed
    ..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors. ..
  39. Lijnen H. Matrix metalloproteinases and cellular fibrinolytic activity. Biochemistry (Mosc). 2002;67:92-8 pubmed
    ..Furthermore, the temporal and topographic expression pattern of MMP components, as well as studies in gene-deficient mice, suggest a functional role in neointima formation after vascular injury. ..
  40. Andre F, Janssens B, Bruyneel E, van Roy F, Gespach C, Mareel M, et al. Alpha-catenin is required for IGF-I-induced cellular migration but not invasion in human colonic cancer cells. Oncogene. 2004;23:1177-86 pubmed
    ..Taken together, our results indicate that functional alpha-catenin is essential for migration but not for invasion, while E-cadherin is involved in both phenomena. ..
  41. Caluwaerts S, Vercruysse L, Luyten C, Pijnenborg R. Endovascular trophoblast invasion and associated structural changes in uterine spiral arteries of the pregnant rat. Placenta. 2005;26:574-84 pubmed
  42. Pirson L, Baron F, Meuris N, Giet O, Castermans E, Greimers R, et al. Despite inhibition of hematopoietic progenitor cell growth in vitro, the tyrosine kinase inhibitor imatinib does not impair engraftment of human CD133+ cells into NOD/SCIDbeta2mNull mice. Stem Cells. 2006;24:1814-21 pubmed
    ..In summary, our results suggest that, despite inhibition of hematopoietic progenitor cell growth in vitro, imatinib does not interfere with hematopoietic stem cell engraftment. ..
  43. de Leval X, Dassesse T, Dogne J, Waltregny D, Bellahcene A, Benoit V, et al. Evaluation of original dual thromboxane A2 modulators as antiangiogenic agents. J Pharmacol Exp Ther. 2006;318:1057-67 pubmed
    ..These data suggest that our original dual TXA(2) inhibitors bear antiangiogenic properties, mainly by inhibiting endothelial cell migration. ..
  44. Vandercappellen J, Noppen S, Verbeke H, Put W, Conings R, Gouwy M, et al. Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells. J Leukoc Biol. 2007;82:1519-30 pubmed
    ..Application of angiostatic CXCL4L1/PF-4var without attraction of protumoral phagocytes may be beneficial in cancer therapy. ..
  45. Dhaese S, Jonckheere V, Goethals M, Waltregny D, Vandekerckhove J, Ampe C, et al. Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta15. FEBS Lett. 2007;581:4809-15 pubmed
    ..In combination, this experimentally validates TbNB as functional homologue of rat Tb15 in the human organism and clarifies the current composition of the human Tb family. ..
  46. Margagliotti S, Clotman F, Pierreux C, Beaudry J, Jacquemin P, Rousseau G, et al. The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration. Dev Biol. 2007;311:579-89 pubmed
    ..This network operating at the onset of liver development contains candidate genes for investigation of liver carcinogenesis. ..
  47. Mottet D, Bellahcene A, Pirotte S, Waltregny D, Deroanne C, Lamour V, et al. Histone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesis. Circ Res. 2007;101:1237-46 pubmed
    ..Because angiogenesis is required for tumor progression, HDAC7 may represent a rational target for therapeutic intervention against cancer. ..
  48. Van Troys M, Huyck L, Leyman S, Dhaese S, Vandekerkhove J, Ampe C. Ins and outs of ADF/cofilin activity and regulation. Eur J Cell Biol. 2008;87:649-67 pubmed publisher
    ..In this framework, we describe current views on how ADF/cofilins function in migrating and invading cells. ..
  49. Shimizu T, Owsianik G, Freichel M, Flockerzi V, Nilius B, Vennekens R. TRPM4 regulates migration of mast cells in mice. Cell Calcium. 2009;45:226-32 pubmed publisher
    ..Thus, our results suggest that TRPM4 is critically involved in migration of BMMCs by regulation of Ca(2+)-dependent actin cytoskeleton rearrangements. ..
  50. Delanote V, Vanloo B, Catillon M, Friederich E, Vandekerckhove J, Gettemans J. An alpaca single-domain antibody blocks filopodia formation by obstructing L-plastin-mediated F-actin bundling. FASEB J. 2010;24:105-18 pubmed publisher
    ..We used recombinant alpaca-derived L-plastin single-domain antibodies (nanobodies) as effector of L-plastin function in cells. ..
  51. Vellema M, Van der Linden A, Gahr M. Area-specific migration and recruitment of new neurons in the adult songbird brain. J Comp Neurol. 2010;518:1442-59 pubmed publisher
    ..Thus, different mechanisms appear to organize area-specific neuron recruitment in different recipients of the adult songbird brain, unrelated to global plasticity of brain regions...
  52. Krysko O, Bottelbergs A, Van Veldhoven P, Baes M. Combined deficiency of peroxisomal beta-oxidation and ether lipid synthesis in mice causes only minor cortical neuronal migration defects but severe hypotonia. Mol Genet Metab. 2010;100:71-6 pubmed publisher
  53. Giang Ho T, Stultiens A, Dubail J, Lapiere C, Nusgens B, Colige A, et al. RhoGDI?-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis. Mol Biol Cell. 2011;22:3263-75 pubmed publisher
    ..This study demonstrates the dynamic balance inside the RhoGTPase network and illustrates its biological relevance in cancer progression. ..
  54. Tondeleir D, Lambrechts A, Muller M, Jonckheere V, Doll T, Vandamme D, et al. Cells lacking ?-actin are genetically reprogrammed and maintain conditional migratory capacity. Mol Cell Proteomics. 2012;11:255-71 pubmed publisher
  55. Brasseur A, Rotureau B, Vermeersch M, Blisnick T, Salmon D, Bastin P, et al. Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms. Eukaryot Cell. 2013;12:168-81 pubmed publisher
    ..We propose that TbFKBP12 differentially affects stage-specific processes through association with the cytoskeleton. ..
  56. Santos C, Boaventura V, Ribeiro Cardoso C, Tavares N, Lordelo M, Noronha A, et al. CD8(+) granzyme B(+)-mediated tissue injury vs. CD4(+)IFN?(+)-mediated parasite killing in human cutaneous leishmaniasis. J Invest Dermatol. 2013;133:1533-40 pubmed publisher
    ..Our results reveal a dichotomy in human CL: CD8(+) granzyme B(+)T cells mediate tissue injury, whereas CD4(+)IFN-?(+)T cells mediate parasite killing. ..
  57. Dynoodt P, Speeckaert R, De Wever O, Chevolet I, Brochez L, Lambert J, et al. miR-145 overexpression suppresses the migration and invasion of metastatic melanoma cells. Int J Oncol. 2013;42:1443-51 pubmed publisher
    ..Despite the fact that it remains unclear which genes or pathways are regulated by miR-145 in melanoma, miR-145 may serve as a useful therapeutic agent in melanoma when re-expressed in situ. ..
  58. De Ceuninck L, Wauman J, Masschaele D, Peelman F, Tavernier J. Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing. J Cell Sci. 2013;126:3770-81 pubmed publisher
    ..Balanced reciprocal cross-regulation of RNF41 and USP8 thus determines whether receptors are sorted for lysosomal degradation or recycling, this way regulating basal cytokine receptor levels. ..
  59. Bentley K, Franco C, Philippides A, Blanco R, Dierkes M, Gebala V, et al. The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nat Cell Biol. 2014;16:309-21 pubmed publisher
    ..Our results provide a mechanistic concept for how cells rearrange during normal sprouting and how rearrangement switches to generate abnormal vessels in pathologies. ..
  60. Noe V, Willems J, Vandekerckhove J, Roy F, Bruyneel E, Mareel M. Inhibition of adhesion and induction of epithelial cell invasion by HAV-containing E-cadherin-specific peptides. J Cell Sci. 1999;112 ( Pt 1):127-35 pubmed
    ..In this way such cadherin fragments may induce and support cancer invasion. ..
  61. Munaut C, Salonurmi T, Kontusaari S, Reponen P, Morita T, Foidart J, et al. Murine matrix metalloproteinase 9 gene. 5'-upstream region contains cis-acting elements for expression in osteoclasts and migrating keratinocytes in transgenic mice. J Biol Chem. 1999;274:5588-96 pubmed
  62. Vermaelen K, Cataldo D, Tournoy K, Maes T, Dhulst A, Louis R, et al. Matrix metalloproteinase-9-mediated dendritic cell recruitment into the airways is a critical step in a mouse model of asthma. J Immunol. 2003;171:1016-22 pubmed
    ..We conclude that the specific absence of MMP-9 activity inhibits the development of allergic airway inflammation by impairing the recruitment of DCs into the airways and the local production of DC-derived proallergic chemokines. ..
  63. Wittamer V, Franssen J, Vulcano M, Mirjolet J, Le Poul E, Migeotte I, et al. Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J Exp Med. 2003;198:977-85 pubmed
    ..Therefore, chemerin appears as a potent chemoattractant protein of a novel class, which requires proteolytic activation and is specific for APCs. ..
  64. Boseret G, Ball G, Balthazart J. The microtubule-associated protein doublecortin is broadly expressed in the telencephalon of adult canaries. J Chem Neuroanat. 2007;33:140-54 pubmed
  65. De Smedt M, Taghon T, Van de Walle I, De Smet G, Leclercq G, Plum J. Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells. Blood. 2007;110:2696-703 pubmed
    ..Peripheral blood NK cells were unable to induce cyCD3 expression after DL1 exposure, indicating that Notch-dependent cyCD3 expression can only be achieved during the early phase of NK-cell differentiation. ..
  66. Kesteman N, Vansanten G, Pajak B, Goyert S, Moser M. Injection of lipopolysaccharide induces the migration of splenic neutrophils to the T cell area of the white pulp: role of CD14 and CXC chemokines. J Leukoc Biol. 2008;83:640-7 pubmed
    ..We conclude that neutrophils may interact with naïve T cells upon infection/inflammation and that the migration of neutrophils in the lymphoid organs and in the periphery is regulated differently by a signal transduced by CD14. ..
  67. Stamatopoulos B, Haibe Kains B, Equeter C, Meuleman N, Soree A, De Bruyn C, et al. Gene expression profiling reveals differences in microenvironment interaction between patients with chronic lymphocytic leukemia expressing high versus low ZAP70 mRNA. Haematologica. 2009;94:790-9 pubmed publisher
  68. Anguille S, Smits E, Cools N, Goossens H, Berneman Z, Van Tendeloo V. Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties. J Transl Med. 2009;7:109 pubmed publisher
    ..The results of the present study might pave the way for the implementation of IL-15 DCs in immunotherapy protocols. ..
  69. Van den Abbeele A, De Clercq S, De Ganck A, De Corte V, Van Loo B, Soror S, et al. A llama-derived gelsolin single-domain antibody blocks gelsolin-G-actin interaction. Cell Mol Life Sci. 2010;67:1519-35 pubmed publisher
    ..We conclude that VHHs represent a potent way of blocking structural proteins and that actin nucleation by gelsolin is more complex than previously anticipated. ..
  70. Jacobs K, Van Gele M, Forsyth R, Brochez L, Vanhoecke B, De Wever O, et al. P-cadherin counteracts myosin II-B function: implications in melanoma progression. Mol Cancer. 2010;9:255 pubmed publisher
    ..Therefore, we conclude that P-cadherin counteracts the expression and function of myosin II-B, resulting in the suppression of the invasive and migratory behaviour of BLM melanoma cells. ..
  71. Ruiz de Almodovar C, Coulon C, Salin P, Knevels E, Chounlamountri N, Poesen K, et al. Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J Neurosci. 2010;30:15052-66 pubmed publisher
    ..These findings identify a previously unknown role for VEGF in neuronal migration...
  72. Aranguren X, Beerens M, Vandevelde W, Dewerchin M, Carmeliet P, Luttun A. Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis. Biochem Biophys Res Commun. 2011;410:121-6 pubmed publisher
    ..Therefore, the role of NR2F2 in EC fate determination is evolutionary conserved...
  73. Glorieux C, Dejeans N, Sid B, Beck R, Calderon P, Verrax J. Catalase overexpression in mammary cancer cells leads to a less aggressive phenotype and an altered response to chemotherapy. Biochem Pharmacol. 2011;82:1384-90 pubmed publisher
  74. Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira J, et al. Oxysterols direct immune cell migration via EBI2. Nature. 2011;475:524-7 pubmed publisher
    ..This demonstrates that CH25H generates EBI2 biological activity in vivo and indicates that the EBI2-oxysterol signalling pathway has an important role in the adaptive immune response. ..
  75. Dullaers M, De Bruyne R, Ramadani F, Gould H, Gevaert P, Lambrecht B. The who, where, and when of IgE in allergic airway disease. J Allergy Clin Immunol. 2012;129:635-45 pubmed publisher
    ..We further consider the therapeutic implications of the insights gained. ..
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