Genomes and Genes
Experts and Doctors on cell membrane in Switzerland
Topic: cell membrane
Publications186 found, 100 shown here
- Schlattner U, Gehring F, Vernoux N, Tokarska Schlattner M, Neumann D, Marcillat O, et al. C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase. J Biol Chem. 2004;279:24334-42 pubmed..These results are discussed in regard to MtCK microcompartments and evolution. ..
- Züllig S, Neukomm L, Jovanovic M, Charette S, Lyssenko N, Halleck M, et al. Aminophospholipid translocase TAT-1 promotes phosphatidylserine exposure during C. elegans apoptosis. Curr Biol. 2007;17:994-9 pubmed..tat-1(RNAi) also reduced the efficiency of cell-corpse clearance, suggesting that PS exposure acts as an "eat-me" signal in worms. We propose that tat-1 homologs might also play an important role in PS exposure in mammals. ..
- Conzelmann A, Riezman H, Desponds C, Bron C. A major 125-kd membrane glycoprotein of Saccharomyces cerevisiae is attached to the lipid bilayer through an inositol-containing phospholipid. EMBO J. 1988;7:2233-40 pubmed..We find that sec18 cells, when grown at 37 degrees C, do add phospholipid anchors to newly synthesized glycoproteins. This indicates that these anchors are added in the rough endoplasmic reticulum. ..
- Schimmöller F, Singer Krüger B, Schroder S, Kruger U, Barlowe C, Riezman H. The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi. EMBO J. 1995;14:1329-39 pubmed..We propose that Emp24p is involved in the sorting and/or concentration of a subset of secretory proteins into ER-derived transport vesicles. ..
- Anner B, Volet B. Uptake of reconstituted Na,K-ATPase vesicles by isolated lymphocytes measured by FACS, confocal microscopy and spectrofluorometry. Cell Biochem Biophys. 1999;30:437-54 pubmed
- Thome M, Gaide O, Micheau O, Martinon F, Bonnet D, Gonzalez M, et al. Equine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue, bcl-10. J Cell Biol. 2001;152:1115-22 pubmed
- Lundstrom K, Schweitzer C, Rotmann D, Hermann D, Schneider E, Ehrengruber M. Semliki Forest virus vectors: efficient vehicles for in vitro and in vivo gene delivery. FEBS Lett. 2001;504:99-103 pubmed..The same SFV stock solutions used for the infection of mammalian cells in culture have also been successfully applied for efficient transgene expression in organotypic hippocampal slices, as well as in vivo in rodent brain. ..
- Schmid Grendelmeier P, Altznauer F, Fischer B, Bizer C, Straumann A, Menz G, et al. Eosinophils express functional IL-13 in eosinophilic inflammatory diseases. J Immunol. 2002;169:1021-7 pubmed..In conclusion, human eosinophils are able to produce and release functional IL-13 in eosinophilic inflammatory responses. ..
- Köffel R, Tiwari R, Falquet L, Schneiter R. The Saccharomyces cerevisiae YLL012/YEH1, YLR020/YEH2, and TGL1 genes encode a novel family of membrane-anchored lipases that are required for steryl ester hydrolysis. Mol Cell Biol. 2005;25:1655-68 pubmed..The three yeast enzymes constitute a novel class of membrane-anchored lipases that differ in topology and subcellular localization. ..
- Bieniossek C, Schalch T, Bumann M, Meister M, Meier R, Baumann U. The molecular architecture of the metalloprotease FtsH. Proc Natl Acad Sci U S A. 2006;103:3066-71 pubmed publisher..The different symmetries of protease and AAA rings suggest a possible translocation mechanism of the target polypeptide chain into the interior of the molecule where the proteolytic sites are located...
- Gronemeyer T, Chidley C, Juillerat A, Heinis C, Johnsson K. Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling. Protein Eng Des Sel. 2006;19:309-16 pubmed..The results furthermore identify two regions of the protein outside the active site that influence the activity of the protein towards BG derivatives. ..
- Vihanto M, Vindis C, Djonov V, Cerretti D, Huynh Do U. Caveolin-1 is required for signaling and membrane targeting of EphB1 receptor tyrosine kinase. J Cell Sci. 2006;119:2299-309 pubmed..Taken together, our findings establish caveolin-1 as an important regulator of downstream signaling and membrane targeting of EphB1. ..
- Ehrenhofer Murray A, Seitz M, Sengstag C. The Sge1 protein of Saccharomyces cerevisiae is a membrane-associated multidrug transporter. Yeast. 1998;14:49-65 pubmed..Furthermore, Sge1 was highly enriched in preparations of yeast plasma membranes. In analogy to other multidrug-resistance proteins, we suggest that Sge1 functions as a drug export permease. ..
- Mastroberardino L, Spindler B, Pfeiffer R, Skelly P, Loffing J, Shoemaker C, et al. Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature. 1998;395:288-91 pubmed..The coexpression of h4F2hc is required for surface expression of these permease-related light chains, which belong to a new family of amino-acid transporters that form heterodimers with cell-surface glycoproteins. ..
- Locher K, Rees B, Koebnik R, Mitschler A, Moulinier L, Rosenbusch J, et al. Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes. Cell. 1998;95:771-8 pubmed..Our findings reveal the mechanism of signal transmission and suggest how the energy-transducing TonB complex senses ligand binding...
- Caldelari R, de Bruin A, Baumann D, Suter M, Bierkamp C, Balmer V, et al. A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris. J Cell Biol. 2001;153:823-34 pubmed
- Park J, Hill M, Hess D, Brazil D, Hofsteenge J, Hemmings B. Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity. J Biol Chem. 2001;276:37459-71 pubmed..Thus, these data suggest that PDK1 activity is regulated by reversible phosphorylation, possibly by a member of the Src kinase family. ..
- Capitani G, Rossmann R, Sargent D, Gr tter M, Richmond T, Hennecke H. Structure of the soluble domain of a membrane-anchored thioredoxin-like protein from Bradyrhizobium japonicum reveals unusual properties. J Mol Biol. 2001;311:1037-48 pubmed publisher..The TlpA(sol) structure paves the way towards unraveling important structure-function relationships by rational mutagenesis...
- Rimoldi D, Muehlethaler K, Salvi S, Valmori D, Romero P, Cerottini J, et al. Subcellular localization of the melanoma-associated protein Melan-AMART-1 influences the processing of its HLA-A2-restricted epitope. J Biol Chem. 2001;276:43189-96 pubmed..Our data are compatible with the notion that proteins retained in the endoplasmic reticulum are more efficiently degraded and produce more antigenic peptides. ..
- Engel A, Stahlberg H. Aquaglyceroporins: channel proteins with a conserved core, multiple functions, and variable surfaces. Int Rev Cytol. 2002;215:75-104 pubmed..9 A, revealing helices that are similar to those of AQP1. Homology modeling shows the channel region of these distant aquaglyceroporins to be similar, as confirmed by the 2.2-A structure of GlpF from X-ray crystallography. ..
- Enggist E, Thöny Meyer L. The C-terminal flexible domain of the heme chaperone CcmE is important but not essential for its function. J Bacteriol. 2003;185:3821-7 pubmed..Soluble full-length CcmE had low activity in cytochrome c maturation, indicating the importance of the N-terminal membrane anchor for the in vivo function of CcmE. ..
- Veljkovic E, Stasiuk S, Skelly P, Shoemaker C, Verrey F. Functional characterization of Caenorhabditis elegans heteromeric amino acid transporters. J Biol Chem. 2004;279:7655-62 pubmed..Taken together, this study demonstrates that the heteromeric structure and the amino acid exchange function of HATs have been conserved throughout the evolution of nematodes to mammals. ..
- Konig S, Hinard V, Arnaudeau S, Holzer N, Potter G, Bader C, et al. Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation. J Biol Chem. 2004;279:28187-96 pubmed..We propose that Kir2.1 channel activation is a required key early event that initiates myogenesis by turning on myogenin and MEF2 transcription factors via a hyperpolarization-activated Ca(2+)-dependent pathway. ..
- Mercanti V, Charette S, Bennett N, Ryckewaert J, Letourneur F, Cosson P. Selective membrane exclusion in phagocytic and macropinocytic cups. J Cell Sci. 2006;119:4079-87 pubmed..Our results suggest the existence of a new, as yet uncharacterized, sorting mechanism in phagocytic and macropinocytic cups. ..
- Hilbi H. Bacterial jailbreak sounds cellular alarm: phagosome membrane remnants trigger signaling. Cell Host Microbe. 2009;6:102-4 pubmed publisher..Now, Dupont et al. address the fate and signaling functions of pathogen vacuole remnants and show that these membrane fragments trigger host-cell-signaling responses, including polyubiquitination, autophagy, and pyroptosis. ..
- Gouriou Y, Bijlenga P, Demaurex N. Mitochondrial Ca2+ uptake from plasma membrane Cav3.2 protein channels contributes to ischemic toxicity in PC12 cells. J Biol Chem. 2013;288:12459-68 pubmed publisher..1/Cav3.2 silencing. We conclude that the opening of Cav3.2 channels during ischemia contribute to the entry of Ca(2+) ions that are transmitted to mitochondria, resulting in a deleterious mitochondrial Ca(2+) overload. ..
- Demirci E, Junne T, Baday S, Berneche S, Spiess M. Functional asymmetry within the Sec61p translocon. Proc Natl Acad Sci U S A. 2013;110:18856-61 pubmed publisher..Thus, the contribution of hydrophobic residues in the H segment is not simply additive and displays cooperativeness depending on their relative position. ..
- Gatlik Landwojtowicz E, Aänismaa P, Seelig A. The rate of P-glycoprotein activation depends on the metabolic state of the cell. Biochemistry. 2004;43:14840-51 pubmed
- Rubi B, Ljubicic S, Pournourmohammadi S, Carobbio S, Armanet M, Bartley C, et al. Dopamine D2-like receptors are expressed in pancreatic beta cells and mediate inhibition of insulin secretion. J Biol Chem. 2005;280:36824-32 pubmed..Thus, the role played by dopamine in glucose homeostasis might involve dopamine receptors, expressed in pancreatic beta cells, modulating insulin release. ..
- Flahaut M, Rossier B, Firsov D. Respective roles of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMP) in cell surface expression of CRLR/RAMP heterodimeric receptors. J Biol Chem. 2002;277:14731-7 pubmed..Our data argue against a chaperone function for RAMP and identify the role of N-glycosylation in targeting these molecules to the cell surface. ..
- Fleischli C, Verhaagh S, Havenga M, Sirena D, Schaffner W, Cattaneo R, et al. The distal short consensus repeats 1 and 2 of the membrane cofactor protein CD46 and their distance from the cell membrane determine productive entry of species B adenovirus serotype 35. J Virol. 2005;79:10013-22 pubmed
- Guerini D, Pan B, Carafoli E. Expression, purification, and characterization of isoform 1 of the plasma membrane Ca2+ pump: focus on calpain sensitivity. J Biol Chem. 2003;278:38141-8 pubmed..The effect of calpain was not the result of a general higher susceptibility of the PMCA1 to proteolytic degradation, because the pattern of degradation by trypsin was the same in the three isoforms. ..
- Hagedorn M, Rohde K, Russell D, Soldati T. Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts. Science. 2009;323:1729-33 pubmed publisher..This insight offers new directions for research into the spreading of tubercular mycobacteria infections in mammalian cells...
- Fuster D, Zhang J, Shi M, Bobulescu I, Andersson S, Moe O. Characterization of the sodium/hydrogen exchanger NHA2. J Am Soc Nephrol. 2008;19:1547-56 pubmed publisher..In summary, NHA2 is a ubiquitous mammalian sodium proton/exchanger that is restricted to the distal convoluted tubule in the kidney. ..
- Wendeler M, Nufer O, Hauri H. Improved maturation of CFTR by an ER export signal. FASEB J. 2007;21:2352-8 pubmed..Moreover, failure of the valine signal to rescue CFTR-deltaF508 from ER degradation indicates that the inability of CFTR-deltaF508 to leave the ER is unlikely to be due to a malfunctioning ER export signal. ..
- von Allmen C, Bauer M, Dietmeier K, Buser R, Gwerder M, Muntwiler S, et al. Identification of Ly-6K as a novel marker for mouse plasma cells. Mol Immunol. 2008;45:2727-33 pubmed publisher..This novel plasma cell marker shows promise to help broaden our understanding of plasma cell differentiation and function. ..
- Veljkovic E, Bacconi A, Stetak A, Hajnal A, Stasiuk S, Skelly P, et al. Aromatic amino acid transporter AAT-9 of Caenorhabditis elegans localizes to neurons and muscle cells. J Biol Chem. 2004;279:49268-73 pubmed..Taken together, the results show that AAT-9 is expressed in excitable cells of the nematode head and pharynx in which it may provide a pathway for aromatic amino acid transport. ..
- Singer Krüger B, Frank R, Crausaz F, Riezman H. Partial purification and characterization of early and late endosomes from yeast. Identification of four novel proteins. J Biol Chem. 1993;268:14376-86 pubmed..By two-dimensional gel analysis we identified more than 20 proteins spots that are highly enriched in the early/late endosomal fractions. N-terminal protein sequencing resulted in the identification of four novel proteins. ..
- Rajendran C, Gerhardt E, Bjelic S, Gasperina A, Scarduelli M, Pedrosa F, et al. Crystal structure of the GlnZ-DraG complex reveals a different form of PII-target interaction. Proc Natl Acad Sci U S A. 2011;108:18972-6 pubmed publisher..The results explain how the intracellular levels of ATP, ADP, and 2-oxoglutarate regulate the interaction between these three proteins and how DraG discriminates GlnZ from its close paralogue GlnB. ..
- Wellmann H, Gomes M, Lee C, Kayser H. Comparative analysis of neonicotinoid binding to insect membranes: II. An unusual high affinity site for [3H]thiamethoxam in Myzus persicae and Aphis craccivora. Pest Manag Sci. 2004;60:959-70 pubmed..This holds also for other neonicotinoids, as we report in a companion article. ..
- Brinkmann V, Davis M, Heise C, Albert R, Cottens S, Hof R, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002;277:21453-7 pubmed..Our results suggest that FTY720, after phosphorylation, acts through sphingosine 1-phosphate signaling pathways to modulate chemotactic responses and lymphocyte trafficking. ..
- Mundwiler Pachlatko E, Beck H. Maurer's clefts, the enigma of Plasmodium falciparum. Proc Natl Acad Sci U S A. 2013;110:19987-94 pubmed publisher..falciparum, might lead to innovative control strategies and might give us a handle with which to help to eliminate this deadly parasite. ..
- Hajnal A, Klemenz R, Schafer R. Subtraction cloning of H-rev107, a gene specifically expressed in H-ras resistant fibroblasts. Oncogene. 1994;9:479-90 pubmed..Repression of the H-rev107 gene may be closely associated with the loss of density-dependent growth inhibition and with the expression of the neoplastic phenotype. ..
- Hicke L, Zanolari B, Pypaert M, Rohrer J, Riezman H. Transport through the yeast endocytic pathway occurs through morphologically distinct compartments and requires an active secretory pathway and Sec18p/N-ethylmaleimide-sensitive fusion protein. Mol Biol Cell. 1997;8:13-31 pubmed
- Farmer E, Mueller M. ROS-mediated lipid peroxidation and RES-activated signaling. Annu Rev Plant Biol. 2013;64:429-50 pubmed publisher..The majority of the known biological activities of oxygenated lipids (oxylipins) in plants are mediated either by jasmonate perception or through RES signaling networks. ..
- Kuhn Nentwig L, Fedorova I, Lüscher B, Kopp L, Trachsel C, Schaller J, et al. A venom-derived neurotoxin, CsTx-1, from the spider Cupiennius salei exhibits cytolytic activities. J Biol Chem. 2012;287:25640-9 pubmed publisher..Such a dualism is discussed as an important new mechanism for the evolution of spider venomous peptides. ..
- Imhof I, Flury I, Vionnet C, Roubaty C, Egger D, Conzelmann A. Glycosylphosphatidylinositol (GPI) proteins of Saccharomyces cerevisiae contain ethanolamine phosphate groups on the alpha1,4-linked mannose of the GPI anchor. J Biol Chem. 2004;279:19614-27 pubmed..Various models trying to explain how Gpi7p, a plasma membrane protein, directs the addition of ethanolamine phosphate to mannose 2 of the GPI core have been formulated and put to the test. ..
- Keller H, Rentsch P, Hagmann J. Differences in cortical actin structure and dynamics document that different types of blebs are formed by distinct mechanisms. Exp Cell Res. 2002;277:161-72 pubmed..A simplified classification scheme has been developed to relate the type of bleb to specific signals or cell functions. Its application shows that spontaneously blebbing cells form almost exclusively type 1 blebs. ..
- Kamau S, Krämer S, Gunthert M, Wunderli Allenspach H. Effect of the modulation of the membrane lipid composition on the localization and function of P-glycoprotein in MDR1-MDCK cells. In Vitro Cell Dev Biol Anim. 2005;41:207-16 pubmed..These results show that removal of cholesterol modulates the membrane lipid composition, changes the localization of P-gp, and results in loss of P-gp function. ..
- Santuari L, Scacchi E, Rodríguez Villalón A, Salinas P, Dohmann E, Brunoud G, et al. Positional information by differential endocytosis splits auxin response to drive Arabidopsis root meristem growth. Curr Biol. 2011;21:1918-23 pubmed publisher..Thus, the endocytosis pattern provides specific positional information to modulate auxin response. ..
- Feraille E, Beguin P, Carranza M, Gonin S, Rousselot M, Martin P, et al. Is phosphorylation of the alpha1 subunit at Ser-16 involved in the control of Na,K-ATPase activity by phorbol ester-activated protein kinase C?. Mol Biol Cell. 2000;11:39-50 pubmed
- Kellenberger S, Gautschi I, Pfister Y, Schild L. Intracellular thiol-mediated modulation of epithelial sodium channel activity. J Biol Chem. 2005;280:7739-47 pubmed..Finally, substitution experiments reveal that multiple cysteine residues in the amino and carboxyl termini of ENaC subunits are responsible for this thiol-mediated inhibition of ENaC. ..
- Bacac M, Fusco C, Planche A, Santodomingo J, Demaurex N, Leemann Zakaryan R, et al. Securin and separase modulate membrane traffic by affecting endosomal acidification. Traffic. 2011;12:615-26 pubmed publisher..Taken together, our findings identify a new functional role of securin and separase in the modulation of membrane traffic and protein secretion that implicates regulation of V-ATPase assembly and function. ..
- Serrander L, Skarman P, Rasmussen B, Witke W, Lew D, Krause K, et al. Selective inhibition of IgG-mediated phagocytosis in gelsolin-deficient murine neutrophils. J Immunol. 2000;165:2451-7 pubmed..Our data suggest that gelsolin is part of the molecular machinery that distinguishes complement and IgG-mediated phagocytosis. The latter requires a more dynamic reorganization of the cytoskeleton. ..
- Seeger M, Diederichs K, Eicher T, Brandstätter L, Schiefner A, Verrey F, et al. The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance. Curr Drug Targets. 2008;9:729-49 pubmed..The novel transport model merges Jardetzky's alternate access pump mechanism with the rotating site catalysis of F(1)F(0) ATPase and suggests a working hypothesis for the transport mechanism of RND transporters in general. ..
- Berezhnoy D, Nyfeler Y, Gonthier A, Schwob H, Goeldner M, Sigel E. On the benzodiazepine binding pocket in GABAA receptors. J Biol Chem. 2004;279:3160-8 pubmed..We present in addition evidence that gamma(2)Ala-79 is probably located in the access pathway of the ligand to its binding pocket. ..
- Dodd D, Niederoest B, Bloechlinger S, Dupuis L, Loeffler J, Schwab M. Nogo-A, -B, and -C are found on the cell surface and interact together in many different cell types. J Biol Chem. 2005;280:12494-502 pubmed..Nogo-A, -B, and -C share a 180-amino acid C-terminal domain with two highly conserved hydrophobic stretches that could form a channel or transporter in the ER and/or on the cell surface. ..
- Moller J, Luhmann T, Chabria M, Hall H, Vogel V. Macrophages lift off surface-bound bacteria using a filopodium-lamellipodium hook-and-shovel mechanism. Sci Rep. 2013;3:2884 pubmed publisher..Force activated catch bonds enable the long-term survival of the filopodium-fimbrium interactions while soluble mannose inhibitors and CD48 antibodies suppress the contact formation and thereby inhibit subsequent E. coli phagocytosis. ..
- Dahoun T, Grasso L, Vogel H, Pick H. Recombinant expression and functional characterization of mouse olfactory receptor mOR256-17 in mammalian cells. Biochemistry. 2011;50:7228-35 pubmed publisher..By screening a large odorant compound library, we discovered a selective spectrum of potent mOR256-17-specific agonists essential for probing the receptor function for future scaled-up productions. ..
- Stocker H, Andjelkovic M, Oldham S, Laffargue M, Wymann M, Hemmings B, et al. Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science. 2002;295:2088-91 pubmed..Thus, Akt appears to be the only critical target activated by increased PIP3 concentrations in Drosophila. ..
- Estreicher A, Muhlhauser J, Carpentier J, Orci L, Vassalli J. The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol. 1990;111:783-92 pubmed
- Escobar Restrepo J, Huck N, Kessler S, Gagliardini V, Gheyselinck J, Yang W, et al. The FERONIA receptor-like kinase mediates male-female interactions during pollen tube reception. Science. 2007;317:656-60 pubmed..Our findings show that the female control of pollen tube reception is based on a FER-dependent signaling pathway, which may play a role in reproductive isolation barriers. ..
- van Drogen F, Stucke V, Jorritsma G, Peter M. MAP kinase dynamics in response to pheromones in budding yeast. Nat Cell Biol. 2001;3:1051-9 pubmed..Membrane-bound Ste5p can specifically recruit Fus3p and Ste7p to the cell cortex. Ste5p remains stably bound at the plasma membrane, unlike activated Fus3p, which dissociates from Ste5p and translocates to the nucleus. ..
- Chicca A, Marazzi J, Nicolussi S, Gertsch J. Evidence for bidirectional endocannabinoid transport across cell membranes. J Biol Chem. 2012;287:34660-82 pubmed publisher..Our findings suggest that a putative endocannabinoid cell membrane transporter controls the cellular AEA and 2-AG trafficking and metabolism. ..
- Laux T, Fukami K, Thelen M, Golub T, Frey D, Caroni P. GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J Cell Biol. 2000;149:1455-72 pubmed..These results suggest that GMC are functionally and mechanistically related PI(4,5)P(2) modulating proteins, upstream of actin and cell cortex dynamics regulation. ..
- Charette S, Mercanti V, Letourneur F, Bennett N, Cosson P. A role for adaptor protein-3 complex in the organization of the endocytic pathway in Dictyostelium. Traffic. 2006;7:1528-38 pubmed..Our results suggest that AP-3 plays an essential role in the compartmentalization of the endocytic pathway in Dictyostelium. ..
- Brada D, Kerjaschki D, Roth J. Cell type-specific post-Golgi apparatus localization of a "resident" endoplasmic reticulum glycoprotein, glucosidase II. J Cell Biol. 1990;110:309-18 pubmed..The sialylated species were enzymatically active. This study demonstrates than an enzyme presumed to be a resident of the endoplasmic reticulum may show alternative localizations in some cell types. ..
- Vuagnat B, Mach J, Le Doussal J. Activation of the alternative pathway of human complement by autologous cells expressing transmembrane recombinant properdin. Mol Immunol. 2000;37:467-78 pubmed..Finally, we suggest that P could be used for retargeting autologous complement to AP-resistant pathogens and tumor cells. ..
- Berclaz G, Flütsch B, Altermatt H, Rohrbach V, Djonov V, Ziemiecki A, et al. Loss of EphB4 receptor tyrosine kinase protein expression during carcinogenesis of the human breast. Oncol Rep. 2002;9:985-9 pubmed..002) suggesting that in breast cancer, EphB4 expression is not compatible with tumor progression. This raises the possibility that EphB4 could represent a potent tool for therapeutic intervention. ..
- Herbig M, Fromm U, Leuenberger J, Krauss U, Beck Sickinger A, Merkle H. Bilayer interaction and localization of cell penetrating peptides with model membranes: a comparative study of a human calcitonin (hCT)-derived peptide with pVEC and pAntp(43-58). Biochim Biophys Acta. 2005;1712:197-211 pubmed..Generally, we found strong peptide-phospholipid interactions, especially when negatively charged lipids were present. ..
- Hergovich A, Schmitz D, Hemmings B. The human tumour suppressor LATS1 is activated by human MOB1 at the membrane. Biochem Biophys Res Commun. 2006;345:50-8 pubmed
- Andres C, Agne B, Kessler F. The TOC complex: preprotein gateway to the chloroplast. Biochim Biophys Acta. 2010;1803:715-23 pubmed publisher..In this review we will describe the current state of knowledge regarding the composition and function of the TOC complex. ..
- Finka A, Cuendet A, Maathuis F, Saidi Y, Goloubinoff P. Plasma membrane cyclic nucleotide gated calcium channels control land plant thermal sensing and acquired thermotolerance. Plant Cell. 2012;24:3333-48 pubmed..These channels in the plasma membrane respond to increments in the ambient temperature by triggering an optimal HSR, leading to the onset of plant acquired thermotolerance...
- Udayar V, Buggia PrÃ©vot V, Guerreiro R, Siegel G, Rambabu N, Soohoo A, et al. A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of Î²-amyloid production. Cell Rep. 2013;5:1536-51 pubmed publisher..Our results reveal trafficking pathways that regulate AÎ² levels and show how systems biology approaches can unravel the molecular complexity underlying AD. ..
- Xiao Z, Bartsch U, Margolis R, Rougon G, Montag D, Schachner M. Isolation of a tenascin-R binding protein from mouse brain membranes. A phosphacan-related chondroitin sulfate proteoglycan. J Biol Chem. 1997;272:32092-101 pubmed..These observations indicate that TN-R can interact with a phosphacan-related molecule and thereby modulate its inhibitory influence on neuritogenesis. ..
- Desrivieres S, Cooke F, Morales Johansson H, Parker P, Hall M. Calmodulin controls organization of the actin cytoskeleton via regulation of phosphatidylinositol (4,5)-bisphosphate synthesis in Saccharomyces cerevisiae. Biochem J. 2002;366:945-51 pubmed..Finally, the cmd1-226 mutant exhibits reduced levels of phosphatidylinositol (4,5)-bisphosphate. These findings suggest that calmodulin positively controls MSS4 activity and thereby the actin cytoskeleton. ..
- von Ballmoos C, Brunner J, Dimroth P. The ion channel of F-ATP synthase is the target of toxic organotin compounds. Proc Natl Acad Sci U S A. 2004;101:11239-44 pubmed..Taken together these results indicate that the subunit a ion channel is the target site for ATPase inhibition by toxic organotin compounds. An inhibitor interacting specifically with this site has not been reported previously. ..
- Ziegler A, Nervi P, Dürrenberger M, Seelig J. The cationic cell-penetrating peptide CPP(TAT) derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence. Biochemistry. 2005;44:138-48 pubmed..In contrast, no recovery to baseline values was observed after repeated exposures to the CPP, suggesting that the CPP is toxic in long-term applications. ..
- Perez J, Segura J, Abankwa D, Piguet J, Martinez K, Vogel H. Monitoring the diffusion of single heterotrimeric G proteins in supported cell-membrane sheets reveals their partitioning into microdomains. J Mol Biol. 2006;363:918-30 pubmed..We propose that the immobilization of the heterotrimer was caused by its partitioning inside membrane microdomains surrounding GPCRs. ..
- Sugihara K. Self-assembled Lipid Structures as Model Systems for Studying Electrical and Mechanical Properties of Cell Membranes. Chimia (Aarau). 2016;70:805-809 pubmed publisher..These research topics require the application of physical and chemical characterization tools to biological systems, thus are very interdisciplinary. ..
- Locher K, Bass R, Rees D. Structural biology. Breaching the barrier. Science. 2003;301:603-4 pubmed
- Lerch M, Kamimori H, Folkers G, Aguilar M, Beck Sickinger A, Zerbe O. Strongly altered receptor binding properties in PP and NPY chimeras are accompanied by changes in structure and membrane binding. Biochemistry. 2005;44:9255-64 pubmed..Differences in receptor binding properties between the chimeras and their parental peptides are therefore most likely due to changes in the conformation of the micelle-bound peptides. ..
- Mansfeld J, Güttinger S, Hawryluk Gara L, Pante N, Mall M, Galy V, et al. The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. Mol Cell. 2006;22:93-103 pubmed..Importantly, NDC1 interacts with Nup53 in vitro. This suggests that NDC1 function involves forming a link between the NE membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. ..
- Sutterlin C, Horvath A, Gerold P, Schwarz R, Wang Y, Dreyfuss M, et al. Identification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis. EMBO J. 1997;16:6374-83 pubmed..These results suggest that despite the conserved core structure, the GPI biosynthetic machinery may be different enough between mammalian and protozoa to represent a target for anti-protozoan chemotherapy. ..
- Liang Y, Fotiadis D, Filipek S, Saperstein D, Palczewski K, Engel A. Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem. 2003;278:21655-21662 pubmed publisher..This is the first semi-empirical model of a higher order structure of a GPCR in native membranes, and it has profound implications for the understanding of how this receptor interacts with partner proteins. ..
- Ewers H, Smith A, Sbalzarini I, Lilie H, Koumoutsakos P, Helenius A. Single-particle tracking of murine polyoma virus-like particles on live cells and artificial membranes. Proc Natl Acad Sci U S A. 2005;102:15110-5 pubmed..The results suggested that clustering of ganglioside molecules by the multivalent VLPs induced transmembrane coupling that led to confinement of the virus/receptor complex by cortical actin filaments. ..