Experts and Doctors on cell line in Poland


Locale: Poland
Topic: cell line

Top Publications

  1. Kwiatkowska A, Zebrowski J, Oklejewicz B, Czarnik J, Halibart Puzio J, Wnuk M. The age-dependent epigenetic and physiological changes in an Arabidopsis T87 cell suspension culture during long-term cultivation. Biochem Biophys Res Commun. 2014;447:285-91 pubmed publisher
  2. Gomulak P, Klajnert B, Bryszewska M, Majoral J, Caminade A, Blasiak J. Cytotoxicity and genotoxicity of cationic phosphorus-containing dendrimers. Curr Med Chem. 2012;19:6233-40 pubmed
    ..Our results indicate that CPD G3 and G4 are cytotoxic and genotoxic for the assorted human cells. Therefore, CPDs may form stable complexes with DNA and interfere with cellular processes. ..
  3. Pietruczuk K, Jozwik A, Ruckemann Dziurdzińska K, Bryl E, Witkowski J. Cytoprotective effect of lithium against spontaneous and induced apoptosis of lymphoid cell line MOLT-4. Folia Histochem Cytobiol. 2009;47:639-46 pubmed publisher
  4. Skrzyszowska M, Samiec M, Słomski R, Lipinski D, Mały E. Development of porcine transgenic nuclear-transferred embryos derived from fibroblast cells transfected by the novel technique of nucleofection or standard lipofection. Theriogenology. 2008;70:248-59 pubmed publisher
    ..To our knowledge, the novel method of nucleofection is the first to transfect nuclear donor cells in the production of transgenic cloned embryos. ..
  5. Niedziela T, Letowska I, Lukasiewicz J, Kaszowska M, Czarnecka A, Kenne L, et al. Epitope of the vaccine-type Bordetella pertussis strain 186 lipooligosaccharide and antiendotoxin activity of antibodies directed against the terminal pentasaccharide-tetanus toxoid conjugate. Infect Immun. 2005;73:7381-9 pubmed
    ..pertussis 186 LOS. The antipentasaccharide antibodies induced by the conjugate inhibited the secretion of tumor necrosis factor alpha, interleukin-6, and NO by LOS-stimulated J774A.1 cells. ..
  6. Kania K, Dragojew S, Jóźwiak Z. Morphological and biochemical changes in human fibroblast lines induced by anthracyclines during apoptosis. Cell Mol Biol Lett. 2003;8:121-6 pubmed
    ..These results suggest that anthracycline drugs are also able to induce apoptosis in pathological, trisomic cells. ..
  7. Walczak Drzewiecka A, Ratajewski M, Pułaski Ł, Dastych J. DNA methylation-dependent suppression of HIF1A in an immature hematopoietic cell line HMC-1. Biochem Biophys Res Commun. 2010;391:1028-32 pubmed publisher
  8. Kisiela D, Laskowska A, Sapeta A, Kuczkowski M, Wieliczko A, Ugorski M. Functional characterization of the FimH adhesin from Salmonella enterica serovar Enteritidis. Microbiology. 2006;152:1337-46 pubmed
  9. Kowalski J, Samojedny A, Paul M, Pietsz G, Wilczok T. Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages. Pharmacol Rep. 2005;57:390-4 pubmed
    ..2 macrophages at the transcriptional level. In addition, the studied compounds may be the mediators responsible for protective role of a diet high in fruits and vegetables in the cardiovascular and inflammatory diseases. ..

More Information


  1. Szutowicz A, Madziar B, Pawełczyk T, Tomaszewicz M, Bielarczyk H. Effects of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells. J Neurochem. 2004;90:952-61 pubmed
  2. Szurmak B, Strokovskaya L, Mooney B, Randall D, Miernyk J. Expression and assembly of Arabidopsis thaliana pyruvate dehydrogenase in insect cell cytoplasm. Protein Expr Purif. 2003;28:357-61 pubmed
    ..Recombinant E1 was able to decarboxylate [1-14C]pyruvate and was a substrate for in vitro phosphorylation by E1-kinase. ..
  3. Piastowska Ciesielska A, Domińska K, Nowakowska M, Gajewska M, Gajos Michniewicz A, Ochedalski T. Angiotensin modulates human mammary epithelial cell motility. J Renin Angiotensin Aldosterone Syst. 2014;15:419-29 pubmed publisher
    ..The results indicate that angiotensin II modulates cell behaviour via AT1-R and stimulates secretion of MMP-2 by human mammary epithelial cells. ..
  4. Bijak M, Saluk J, Tsirigotis Maniecka M, Komorowska H, Wachowicz B, Zaczynska E, et al. The influence of conjugates isolated from Matricaria chamomilla L. on platelets activity and cytotoxicity. Int J Biol Macromol. 2013;61:218-29 pubmed publisher
    ..Compounds obtained from M. chamomilla L. are potential composite to the development of a new anti-platelet agent, which could be an alternative to the currently used anti-platelet drugs. ..
  5. Cieslak M, Niewiarowska J, Nawrot M, Koziolkiewicz M, Stec W, Cierniewski C. DNAzymes to beta 1 and beta 3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and matrigel. J Biol Chem. 2002;277:6779-87 pubmed
    ..In conclusion, DNAzymes to beta(1) and beta(3) mRNAs with 2'-O-methyl modifications are potentially useful as gene-inactivating agents and may ultimately provide a therapeutic means to inhibit angiogenesis in vivo. ..
  6. Wysokińska E, Cichos J, Zioło E, Bednarkiewicz A, Strządała L, Karbowiak M, et al. Cytotoxic interactions of bare and coated NaGdF4:Yb(3+):Er(3+) nanoparticles with macrophage and fibroblast cells. Toxicol In Vitro. 2016;32:16-25 pubmed publisher
    ..01.01.02-02-002/08) financed by the European Regional Development Fund (Operational Program Innovative Economy, 1.1.2). ..
  7. Gołuński G, Borowik A, Derewońko N, Kawiak A, Rychłowski M, Woziwodzka A, et al. Pentoxifylline as a modulator of anticancer drug doxorubicin. Part II: Reduction of doxorubicin DNA binding and alleviation of its biological effects. Biochimie. 2016;123:95-102 pubmed publisher
    ..Proposed results shed light on the possible doxorubicin chemotherapy modification and its side effects reduction without the loss of its therapeutic potential. ..
  8. Tokarz P, Kaarniranta K, Blasiak J. Inhibition of DNA methyltransferase or histone deacetylase protects retinal pigment epithelial cells from DNA damage induced by oxidative stress by the stimulation of antioxidant enzymes. Eur J Pharmacol. 2016;776:167-75 pubmed publisher
  9. Olejnik A, Kowalska K, Kidoń M, Czapski J, Rychlik J, Olkowicz M, et al. Purple carrot anthocyanins suppress lipopolysaccharide-induced inflammation in the co-culture of intestinal Caco-2 and macrophage RAW264.7 cells. Food Funct. 2016;7:557-64 pubmed publisher
    ..These findings may provide preliminary justification for the use of PCA in further studies focused on the prevention and therapy supporting the conventional treatment of inflammatory bowel diseases. ..
  10. Boncler M, Golanski J, Lukasiak M, Redzynia M, Dastych J, Watala C. A new approach for the assessment of the toxicity of polyphenol-rich compounds with the use of high content screening analysis. PLoS ONE. 2017;12:e0180022 pubmed publisher
    ..This approach should be recommended for series of compounds producing a non-sigmoidal cell response, and for agents with unknown toxicity or mechanisms of action. ..
  11. Radko L, Cybulski W, Rzeski W. The protective effect of silybin against lasalocid cytotoxic exposure on chicken and rat cell lines. Biomed Res Int. 2013;2013:783519 pubmed publisher
    ..It is concluded that the mechanism of cytoprotection results from complex reaction at biochemical and biophysical endpoints during chicken hepatocytes and rat myoblasts cell lines exposure to silybin and lasalocid co-action. ..
  12. Izabela R, Jarosław R, Magdalena A, Piotr R, Ivan K. Transportan 10 improves the anticancer activity of cisplatin. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:485-97 pubmed publisher
    ..Additionally, the complex was relatively safe for non-cancer cells. What is more, TP10 also produced an anticancer effect on HeLa and OS143B cell lines. ..
  13. Prendecka M, Mlak R, Jaszek M, Osińska Jaroszuk M, Jakubiak Hulicz M, Leibold C, et al. Effect of exopolysaccharide from Ganoderma applanatum on the electrical properties of mouse fibroblast cells line L929 culture using an electric cell-substrate impedance sensing (ECIS) - Preliminary study. Ann Agric Environ Med. 2016;23:280-4 pubmed publisher
    ..In the future, following further studies (comprising in preventive and therapeutic actions), GpEPS can be safely used in anti-cancer therapy which does not cause side-effects or damage to healthy cells. ..
  14. Wlodarski P, Maksym R, Oldak M, Jozwiak S, Wojcik A, Jozwiak J. Tuberin-heterozygous cell line TSC2ang1 as a model for tuberous sclerosis-associated skin lesions. Int J Mol Med. 2008;21:245-50 pubmed
    ..Based on these results we propose TSC2ang1 as a good and stable model for pathophysiological and pharmacological studies on skin lesions in TS. ..
  15. Markiewicz Żukowska R, Car H, Naliwajko S, Sawicka D, Szynaka B, Chyczewski L, et al. Ethanolic extract of propolis, chrysin, CAPE inhibit human astroglia cells. Adv Med Sci. 2012;57:208-16 pubmed publisher
    ..This study showed that EEP, chrysin and CAPE reduced viability of human astroglia cells probably due to apoptosis process. ..
  16. Bielarczyk H, Jankowska A, Madziar B, Matecki A, Michno A, Szutowicz A. Differential toxicity of nitric oxide, aluminum, and amyloid beta-peptide in SN56 cholinergic cells from mouse septum. Neurochem Int. 2003;42:323-31 pubmed
    ..Thus, differential vulnerability of brain cholinergic neurons to various degenerative signals may result from their phenotype-dependent ratios of acetylcholine to acetyl-CoA synthesising capacities. ..
  17. Papiewska Pajak I, Boncela J, Przygodzka P, Cierniewski C. Autocrine effects of VEGF-D on endothelial cells after transduction with AD-VEGF-D(DeltaNDeltaC). Exp Cell Res. 2010;316:907-14 pubmed publisher
  18. Kar S, Gajewicz A, Roy K, Leszczynski J, Puzyn T. Extrapolating between toxicity endpoints of metal oxide nanoparticles: Predicting toxicity to Escherichia coli and human keratinocyte cell line (HaCaT) with Nano-QTTR. Ecotoxicol Environ Saf. 2016;126:238-244 pubmed publisher
    ..coli are identified from the developed nano quantitative toxicity-toxicity relationship (nano-QTTR) models. ..
  19. Olczak M, Olczak T. N-glycosylation sites of plant purple acid phosphatases important for protein expression and secretion in insect cells. Arch Biochem Biophys. 2007;461:247-54 pubmed
    ..However, the N-glycan located at the polypeptide C-terminus was crucial for secretion of both enzymes. PAP specific activity of glycosylation mutants successfully secreted was similar to the wild-type recombinant proteins. ..
  20. Jabłońska Trypuć A, Matejczyk M, Czerpak R. N6-benzyladenine and kinetin influence antioxidative stress parameters in human skin fibroblasts. Mol Cell Biochem. 2016;413:97-107 pubmed publisher
    ..Both show antioxidant properties and are potentially powerful agents with applications in the prevention and treatment of many diseases connected with oxidative stress in skin, for example, psoriasis. ..
  21. Miltyk W, Karna E, Palka J. Prolidase-independent mechanism of camptothecin-induced inhibition of collagen biosynthesis in cultured human skin fibroblasts. J Biochem. 2007;141:287-92 pubmed
    ..The data suggest that CPT induces inhibition of collagen biosynthesis in cultured human skin fibroblasts by stimulation of NF-kappaB signalling. ..
  22. Wrześniok D, Beberok A, Otręba M, Buszman E. Netilmicin-induced modulation of melanogenesis in HEMa-LP melanocytes. Acta Pol Pharm. 2013;70:803-8 pubmed
    ..Netilmicin-induced modulation of melanogenesis in melanocytes in vitro may explain a potential role of melanin and melanocytes in the mechanisms of aminoglycosides ototoxic effects in vivo. ..
  23. Mazur Bialy A, Pochec E, Plytycz B. Immunomodulatory effect of riboflavin deficiency and enrichment - reversible pathological response versus silencing of inflammatory activation. J Physiol Pharmacol. 2015;66:793-802 pubmed
    ..We conclude that short-term riboflavin deficiency significantly impairs the ability of macrophages to induce proper immune response, while riboflavin enrichment decreases the proinflammatory activation of macrophages. ..
  24. Zielichowska A, Daczewska M, Saczko J, Michel O, Kulbacka J. Applications of calcium electroporation to effective apoptosis induction in fibrosarcoma cells and stimulation of normal muscle cells. Bioelectrochemistry. 2016;109:70-8 pubmed publisher
    ..Additionally, sPLA2 pro-tumorigenic influence was proved by immunocytochemistry. Moreover, EP with 0.5 mM of Ca(2+) slightly stimulates the normal muscle cells - L6 to increase proliferation. ..
  25. Robaszkiewicz A, Qu C, Wiśnik E, Ploszaj T, Mirsaidi A, Kunze F, et al. ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β. Sci Rep. 2016;6:21131 pubmed publisher
  26. Lukasiewicz J, Jachymek W, Niedziela T, Dzieciatkowska M, Lakomska J, Miedzybrodzki R, et al. Serological characterization of anti-endotoxin serum directed against the conjugate of oligosaccharide core of Escherichia coli type R4 with tetanus toxoid. FEMS Immunol Med Microbiol. 2003;37:59-67 pubmed
    ..The serum inhibited endotoxin-induced tumor necrosis factor alpha and nitric oxide synthesis by the J-774A.1 cell line and attenuated pulmonary retention of YAC-1 cells. ..
  27. Wróbel A, Gregoraszczuk E. Effects of single and repeated in vitro exposure of three forms of parabens, methyl-, butyl- and propylparabens on the proliferation and estradiol secretion in MCF-7 and MCF-10A cells. Pharmacol Rep. 2013;65:484-93 pubmed
    ..In MCF-10A by an unknown mechanism, independent on stimulatory action on estradiol section, which requires further investigation. ..
  28. Mikłosz A, Łukaszuk B, Zendzian Piotrowska M, Kurek K, Chabowski A. The Effects of AS160 Modulation on Fatty Acid Transporters Expression and Lipid Profile in L6 Myotubes. Cell Physiol Biochem. 2016;38:267-82 pubmed publisher
    ..Interestingly, the intervention also simultaneously decreased the content of sphingolipids. ..
  29. Ainola M, Tomaszewski W, Ostrowska B, Wesolowska E, Wagner H, Swieszkowski W, et al. A bioactive hybrid three-dimensional tissue-engineering construct for cartilage repair. J Biomater Appl. 2016;30:873-85 pubmed publisher
    ..This allows time for the slowly progressing, multiphase true cartilage regeneration. ..
  30. Gogol M, Ostrowska D, Klaga K, Bocheńska O, Wolak N, Aoki W, et al. Inactivation of α1-proteinase inhibitor by Candida albicans aspartic proteases favors the epithelial and endothelial cell colonization in the presence of neutrophil extracellular traps. Acta Biochim Pol. 2016;63:167-175 pubmed publisher
    ..The findings presented here suggest a novel strategy used by C. albicans for the colonization of host tissues and overcoming the host defense. ..
  31. Gęgotek A, Biernacki M, Ambrożewicz E, Surażyński A, Wroński A, Skrzydlewska E. The cross-talk between electrophiles, antioxidant defence and the endocannabinoid system in fibroblasts and keratinocytes after UVA and UVB irradiation. J Dermatol Sci. 2016;81:107-17 pubmed publisher
    ..The differences demonstrated in the response of the tested cells to UV irradiation allow for a better understanding of the mechanisms occurring in the human skin, which may be exploited for future therapies in dermatology. ..
  32. Siemion I, Kluczyk A, Wieczorek Z. Anti-IL-1 activity of peptide fragments of IL-1 family proteins. Peptides. 1998;19:373-82 pubmed
  33. Inkielewicz Stępniak I, Santos Martinez M, Medina C, Radomski M. Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride. Int J Nanomedicine. 2014;9:1677-87 pubmed publisher
    ..However, risks associated with the co-exposure of local cells and tissues to these xenobiotics are not clear. Therefore, we have evaluated the effects of AgNPs and F co-exposure on human gingival fibroblast cells...
  34. Gizak A, Maciaszczyk Dziubinska E, Jurowicz M, Rakus D. Muscle FBPase is targeted to nucleus by its 203KKKGK207 sequence. Proteins. 2009;77:262-7 pubmed publisher
  35. Boncela J, Przygodzka P, Papiewska Pajak I, Wyroba E, Cierniewski C. Association of plasminogen activator inhibitor type 2 (PAI-2) with proteasome within endothelial cells activated with inflammatory stimuli. J Biol Chem. 2011;286:43164-71 pubmed publisher
    ..This suggests that PAI-2, in endothelial cells induced with inflammatory stimuli, can inhibit proteasome and thus tilt the balance favoring proapoptotic signaling. ..
  36. Swiatkowska M, Szymanski J, Padula G, Cierniewski C. Interaction and functional association of protein disulfide isomerase with alphaVbeta3 integrin on endothelial cells. FEBS J. 2008;275:1813-23 pubmed publisher
  37. Gorlach S, Wagner W, Podsedek A, Sosnowska D, Dastych J, Koziołkiewicz M. Polyphenols from evening primrose ( Oenothera paradoxa ) defatted seeds induce apoptosis in human colon cancer Caco-2 cells. J Agric Food Chem. 2011;59:6985-97 pubmed publisher
    ..The fractions strongly and dose-dependently reduced Caco-2 cell numbers, whereas HT-29 and IEC-6 cells were affected to lesser extents...
  38. Kalwarczyk T, Ziebacz N, Bielejewska A, Zaboklicka E, Koynov K, Szymanski J, et al. Comparative analysis of viscosity of complex liquids and cytoplasm of mammalian cells at the nanoscale. Nano Lett. 2011;11:2157-63 pubmed publisher
    ..4 × 10(-2) and 2.4 × 10(-2) Pa·s for HeLa and Swiss 3T3 cells, respectively. Our results are persistent for the lengths scales from 0.14 nm to a few hundred nanometers. ..
  39. Spohr de Faundez I, Niemialtowski M, Malicka E, Malicki K, Gierynska M, Popis A. Electron microscopy, plaque assay and preliminary serological characterization of three ectromelia virus strains isolated in Poland in the period 1986-1988. Arch Virol. 1990;114:285-91 pubmed
    ..The mean diameter of plaques produced by EV strains was 0.76 mm (range 0.5-1.0 mm). The neutralizing properties of the tested sera were evaluated by seroneutralization (SN) and hemagglutination inhibition (HAI) tests...
  40. Maszczak Seneczko D, Sosicka P, Majkowski M, Olczak T, Olczak M. UDP-N-acetylglucosamine transporter and UDP-galactose transporter form heterologous complexes in the Golgi membrane. FEBS Lett. 2012;586:4082-7 pubmed publisher
    ..For the first time we demonstrated in vivo homodimerization of the NGT nucleotide sugar transporter. In conclusion, we suggest that NGT and UGT function in glycosylation is combined via their mutual interaction. ..
  41. Wavhale R, Martis E, Ambre P, Wan B, Franzblau S, Iyer K, et al. Discovery of new leads against Mycobacterium tuberculosis using scaffold hopping and shape based similarity. Bioorg Med Chem. 2017;25:4835-4844 pubmed publisher
    ..Interestingly the benzimidazole compound (4a) is as potent as the parent molecule BM212 (MIC 2.3?g/ml vs 0.7-1.5?g/ml), but is devoid of the toxicity against HepG2 cell lines (IC50 203.10µM vs 7.8µM). ..
  42. Gawad A, Ptak Belowska A, Brzozowski T, Pawlik W. Monocytes and vascular endothelial cells apoptosis. Role of p-HSP27. J Physiol Pharmacol. 2009;60:55-61 pubmed
    ..Proapoptotic activation mediated by PUMA that was observed seemed to be counterbalanced by significant increase of antiapoptotic HSP70, HSP27 and especially phospho-HSP27 proteins level. ..
  43. Gęgotek A, Bielawska K, Biernacki M, Zaręba I, Surazynski A, Skrzydlewska E. Comparison of protective effect of ascorbic acid on redox and endocannabinoid systems interactions in in vitro cultured human skin fibroblasts exposed to UV radiation and hydrogen peroxide. Arch Dermatol Res. 2017;309:285-303 pubmed publisher
    ..However, this antioxidant cannot efficiently protect cellular macromolecules and avert metabolic dysregulation leading to apoptosis. ..
  44. Gut Winiarska M, Jacobs L, Kerstens H, Bienkowska Szewczyk K. A highly specific and sensitive sandwich blocking ELISA based on baculovirus expressed pseudorabies virus glycoprotein B. J Virol Methods. 2000;88:63-71 pubmed
  45. Olejnik K, Płochocka D, Grynberg M, Goch G, Gruszecki W, Basinska T, et al. Mutational analysis of the AtNUDT7 Nudix hydrolase from Arabidopsis thaliana reveals residues required for protein quaternary structure formation and activity. Acta Biochim Pol. 2009;56:291-300 pubmed
    ..3.3 protein. These are the first studies of the structure-function relationship of AtNUDT7, a Nudix hydrolase of important regulatory function. ..
  46. Pituch Noworolska A, Majka M, Janowska Wieczorek A, Baj Krzyworzeka M, Urbanowicz B, Malec E, et al. Circulating CXCR4-positive stem/progenitor cells compete for SDF-1-positive niches in bone marrow, muscle and neural tissues: an alternative hypothesis to stem cell plasticity. Folia Histochem Cytobiol. 2003;41:13-21 pubmed
  47. Labieniec M, Gabryelak T. Measurement of DNA damage and protein oxidation after the incubation of B14 Chinese hamster cells with chosen polyphenols. Toxicol Lett. 2005;155:15-25 pubmed
    ..The used methods and obtained results provide additional information about the potential use of these phenols not only as antioxidants but also as pro-oxidants in biological systems. ..
  48. Cebrat M, Cebula A, Laszkiewicz A, Kasztura M, Miazek A, Kisielow P. Mechanism of lymphocyte-specific inactivation of RAG-2 intragenic promoter of NWC: implications for epigenetic control of RAG locus. Mol Immunol. 2008;45:2297-306 pubmed publisher
    ..The implications of our findings for understanding mechanisms regulating transcription within RAG/NWC locus in different cells are discussed and the model of epigenetic control of this locus is proposed. ..
  49. Libako P, Castiglioni S, Baldoli E, Mazur A, Nowacki W, Maier J. Blocking the rise of intracellular calcium inhibits the growth of cells cultured in different concentrations of magnesium. Magnes Res. 2012;25:12-20 pubmed publisher
    ..Our results indicate that calcium plays a crucial role in mediating cell proliferation independently from the extracellular concentrations of magnesium...
  50. Bodaszewska Lubas M, Brzychczy Wloch M, Adamski P, Gosiewski T, Strus M, Heczko P. Adherence of group B streptococci to human rectal and vaginal epithelial cell lines in relation to capsular polysaccharides as well as alpha-like protein genes - pilot study. Pol J Microbiol. 2013;62:85-90 pubmed
    ..GBS strains containing the rib gene adhered to the HT-29 and A-431 cell lines more firmly than GBS strains containing other alpha-like protein genes. ..
  51. Milczarek J, Pawlowska R, Zurawiński R, Lukasik B, Garner L, Chworos A. Fluorescence and confocal imaging of mammalian cells using conjugated oligoelectrolytes with phenylenevinylene core. J Photochem Photobiol B. 2017;170:40-48 pubmed publisher
  52. Bucko Justyna M, Lipinski L, Burgering B, Trzeciak L. Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling. FEBS J. 2005;272:6310-23 pubmed
    ..Analysis of peptide sequences identifies the peptide sequence RRSSSY containing Ser5 that is a target for TSSK3 phosphorylation, as an efficient and specific substrate for TSSK3. ..
  53. Walczak Drzewiecka A, Ratajewski M, Wagner W, Dastych J. HIF-1alpha is up-regulated in activated mast cells by a process that involves calcineurin and NFAT. J Immunol. 2008;181:1665-72 pubmed
    ..Thus, accumulation of HIF-1alpha in activated mast cells requires up-regulation of HIF1A gene transcription and depends on the calcineurin-NFAT signaling pathway. ..
  54. Gburek J, Verroust P, Willnow T, Fyfe J, Nowacki W, Jacobsen C, et al. Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. J Am Soc Nephrol. 2002;13:423-30 pubmed
    ..The findings may prove to be essential for further research on the pathophysiology of hemoglobinuric acute renal failure and proteinuria-associated tubulointerstitial nephritis. ..
  55. Torzewska A, Rozalski A. In vitro studies on the role of glycosaminoglycans in crystallization intensity during infectious urinary stones formation. APMIS. 2014;122:505-11 pubmed publisher
    ..Chondroitin sulfates, which accelerate the first stages of infection-induced stones formation, may play an important role in the pathogenesis of infectious urolithiasis...
  56. Nawrot B, Michalak O, De Clercq E, Stec W. Analogues of acyclic nucleosides derived from tris-(hydroxymethyl)phosphine oxide or bis-(hydroxymethyl)phosphinic acid coupled to DNA nucleobases. Antivir Chem Chemother. 2004;15:319-28 pubmed
  57. Noorwez S, Kuksa V, Imanishi Y, Zhu L, Filipek S, Palczewski K, et al. Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa. J Biol Chem. 2003;278:14442-14450 pubmed publisher
    ..These properties suggest that 11-cis-7-ring retinal may be a useful therapeutic agent for the rescue of P23H-opsin and the prevention of retinal degeneration...
  58. Brzezinska M, Szulc I, Brzostek A, Klink M, Kielbik M, Sulowska Z, et al. The role of 3-ketosteroid 1(2)-dehydrogenase in the pathogenicity of Mycobacterium tuberculosis. BMC Microbiol. 2013;13:43 pubmed publisher
  59. Wrześniok D, Beberok A, Otręba M, Buszman E. Modulation of melanogenesis and antioxidant defense system in melanocytes by amikacin. Toxicol In Vitro. 2013;27:1102-8 pubmed publisher
    ..Modulation of melanogenesis and the antioxidant status of melanocytes resulting from the use of amikacin in vitro may explain a potential role of melanin and melanocytes in the mechanisms of aminoglycosides ototoxic effects in vivo...
  60. Rahden Staron I, Szumiło M, Grosicka E, Kraakman van der Zwet M, Zdzienicka M. Defective Brca2 influences topoisomerase I activity in mammalian cells. Acta Biochim Pol. 2003;50:139-44 pubmed
    ..These results indicate that the observed changes in the topoisomerase I activity in V-C8 are due to the defective function of the Brca2 gene. ..
  61. Wrzyszcz A, Wozniak M. On the origin of matrix metalloproteinase-2 and -9 in blood platelets. Platelets. 2012;23:467-74 pubmed publisher
    ..We conclude that the detection of gelatinases in platelets depends on platelet isolation techniques and the degree of leukocyte contamination. ..
  62. Florkowska M, Tymoszuk P, Balwierz A, Skucha A, Kochan J, Wawro M, et al. EGF activates TTP expression by activation of ELK-1 and EGR-1 transcription factors. BMC Mol Biol. 2012;13:8 pubmed publisher
    ..EGF activates TTP expression via ELK-1 and EGR-1 transcription factors. ..
  63. Kowalski A, Zylińska L, Boczek T, Rebas E. GABA-shunt enzymes activity in GH3 cells with reduced level of PMCA2 or PMCA3 isoform. Biochem Biophys Res Commun. 2011;411:815-20 pubmed publisher
    ..Results suggest that PMCA2 and PMCA3 function is rather related to regulation of GABA synthesis and degradation than supplying cells with metabolites, which can be potentially energetic source. ..
  64. Minczuk M, Mroczek S, Pawlak S, Stepien P. Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP. FEBS J. 2005;272:5008-19 pubmed
    ..The HBXIP binding domain was found to be important for mitochondrial import and stability of the Suv3 protein in vivo. We discuss the possible involvement of the hSuv3p-HBXIP interaction in the survivin-dependent antiapoptotic pathway. ..
  65. Grosicka E, Sadurska B, Szumiło M, Grzela T, Łazarczyk P, Niderla Bielinska J, et al. Effect of glutathione depletion on apoptosis induced by thiram in Chinese hamster fibroblasts. Int Immunopharmacol. 2005;5:1945-56 pubmed
    ..On the other hand, thiram effects were enhanced by the previous depletion of cellular GSH by L-buthionine-(S,R)-sulfoximine (BSO)...
  66. Lukasiewicz J, Niedziela T, Jachymek W, Kenne L, Lugowski C. Structure of the lipid A-inner core region and biological activity of Plesiomonas shigelloides O54 (strain CNCTC 113/92) lipopolysaccharide. Glycobiology. 2006;16:538-50 pubmed
    ..shigelloides O54 LPS, resolving the entire molecule. Biological activities and observed discrepancy between in vitro and in vivo activity of P. shigelloides and Escherichia coli LPS are discussed...
  67. Grymek K, Łukasiewicz S, Faron Góreckaa A, Tworzydlo M, Polit A, Dziedzicka Wasylewska M. Role of silent polymorphisms within the dopamine D1 receptor associated with schizophrenia on D1-D2 receptor hetero-dimerization. Pharmacol Rep. 2009;61:1024-33 pubmed
  68. Szejk M, Poplawski T, Czubatka Bieńkowska A, Olejnik A, Pawlaczyk Graja I, Gancarz R, et al. A comparative study on the radioprotective potential of the polyphenolic glycoconjugates from medicinal plants of Rosaceae and Asteraceae families versus their aglycones. J Photochem Photobiol B. 2017;171:50-57 pubmed publisher
    ..In addition, they possess many advantages, compared to the synthetic polyphenolic compounds or the plant extracts, such as water-solubility and minor toxicity. ..
  69. Arkusz J, Stepnik M, Lewińska D, Stańczyk M, Palus J, Dziubałtowska E. Interleukin-1beta expression in murine J774A.1 macrophages exposed to platinum compounds: the role of p38 and ERK 1/2 mitogen-activated protein kinases. Toxicol In Vitro. 2007;21:371-9 pubmed
    ..These data suggest that p38 MAPK and ERK 1/2 play an important role in induction of IL-1beta expression in J774A.1 macrophages exposed to test platinum compounds...
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    ..We hypothesize that the externalization of some nuclear antigens because of NB-UVB exposure might be responsible for exacerbation of skin symptoms in patients suffering from LE. ..
  71. Acuna Hidalgo R, Deriziotis P, Steehouwer M, Gilissen C, Graham S, van Dam S, et al. Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies. PLoS Genet. 2017;13:e1006683 pubmed publisher
    ..Drawing on previous studies of somatic SETBP1 mutations in leukemia, our results reveal a genotype-phenotype correlation in germline SETBP1 mutations spanning a molecular, cellular and clinical phenotype. ..
  72. Skuland T, Refsnes M, Magnusson P, Oczkowski M, Gromadzka Ostrowska J, Kruszewski M, et al. Proinflammatory effects of diesel exhaust particles from moderate blend concentrations of 1st and 2nd generation biodiesel in BEAS-2B bronchial epithelial cells-The FuelHealth project. Environ Toxicol Pharmacol. 2017;52:138-142 pubmed publisher
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  73. Slusarczyk S, Zimmermann S, Kaiser M, Matkowski A, Hamburger M, Adams M. Antiplasmodial and antitrypanosomal activity of tanshinone-type diterpenoids from Salvia miltiorrhiza. Planta Med. 2011;77:1594-6 pubmed publisher
    ..falciparum K1 strain with selectivity indices (SI) from 0.3 to 1.9. IC??s against T. brucei rhodesiense STIB 900 were from 0.5?µM (1,?4) to over 30?µM, and 4 showed the greatest selective activity with an SI of 24. ..
  74. Paplińska Goryca M, Chazan R, Grubek Jaworska H. PDE4 inhibitors have no effect on eotaxin expression in human primary bronchial epithelial cells. Acta Biochim Pol. 2012;59:371-5 pubmed
    ..Thus PDE4 inhibitors have no effect on eotaxin protein expression in human primary bronchial epithelial cells. In vitro experiments should be performed using a primary cell model rather than immortalized lines. ..
  75. Wypasek E, Natorska J, Mazur A, Kołaczkowska E. Toll-like receptors expression and NF-?B activation in peritoneal leukocytes in morphine-mediated impairment of zymosan-induced peritonitis in swiss mice. Arch Immunol Ther Exp (Warsz). 2012;60:373-82 pubmed publisher
    ..Additionally, during zymosan-induced peritonitis, morphine may modulate the NF-?B expression, at least partially, by an up-regulated release of NO, as suggested by others...
  76. Blasiak J, Synowiec E, Tarnawska J, Czarny P, Poplawski T, Reiter R. Dental methacrylates may exert genotoxic effects via the oxidative induction of DNA double strand breaks and the inhibition of their repair. Mol Biol Rep. 2012;39:7487-96 pubmed publisher
    ..Vitamin C or melatonin may reduce the detrimental effects induced by methacrylates applied in dentistry...
  77. Greb Markiewicz B, Orłowski M, Dobrucki J, Ozyhar A. Sequences that direct subcellular traffic of the Drosophila methoprene-tolerant protein (MET) are located predominantly in the PAS domains. Mol Cell Endocrinol. 2011;345:16-26 pubmed publisher
    ..Thus, the intracellular trafficking of MET seems to be regulated by a rather complicated network of different factors. ..
  78. Kruszewski M, Gradzka I, Bartłomiejczyk T, Chwastowska J, Sommer S, Grzelak A, et al. Oxidative DNA damage corresponds to the long term survival of human cells treated with silver nanoparticles. Toxicol Lett. 2013;219:151-9 pubmed publisher
    ..The reported experiments suggest that only the oxidative DNA damage corresponds to the loss of the clonogenic ability of cells treated with AgNPs. ..
  79. Grosicka Maciąg E, Kurpios Piec D, Grzela T, Czeczot H, Skrzycki M, Szumiło M, et al. Protective effect of N-acetyl-L-cysteine against disulfiram-induced oxidative stress and apoptosis in V79 cells. Toxicol Appl Pharmacol. 2010;248:210-6 pubmed publisher
    ..These observations illustrate the importance of the initial cellular redox state in terms of cell response to disulfiram exposure...
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    ..Fc epsilon RI-derived signals engage PKC and upregulate mast cell adhesion in a process which might involve changes in integrin avidity rather than integrin expression. ..
  81. Mezyk Kopec R, Bzowska M, Potempa J, Bzowska M, Jura N, Sroka A, et al. Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis. Infect Immun. 2005;73:1506-14 pubmed
    ..Thus, gingipains are able not only to cleave soluble TNF-alpha but also to destroy the membrane form of the cytokine, which may additionally dysregulate the cytokine network. ..
  82. Starzynski R, Gonçalves A, Muzeau F, Tyrolczyk Z, Smuda E, Drapier J, et al. STAT5 proteins are involved in down-regulation of iron regulatory protein 1 gene expression by nitric oxide. Biochem J. 2006;400:367-75 pubmed
    ..These findings provide evidence that STAT5 proteins play a role in NO-mediated down-regulation of IRP1 gene expression. ..
  83. Suchanski J, Tejchman A, Zacharski M, Piotrowska A, Grzegrzolka J, Chodaczek G, et al. Podoplanin increases the migration of human fibroblasts and affects the endothelial cell network formation: A possible role for cancer-associated fibroblasts in breast cancer progression. PLoS ONE. 2017;12:e0184970 pubmed publisher
    ..Second, using immunofluorescence, the co-localization of PDPN-positive CAFs with blood vessels stained with antibody directed against CD34 was observed in tumor stroma of IDC samples. ..
  84. Grosicka Maciag E, Kurpios D, Czeczot H, Szumiło M, Skrzycki M, Suchocki P, et al. Changes in antioxidant defense systems induced by thiram in V79 Chinese hamster fibroblasts. Toxicol In Vitro. 2008;22:28-35 pubmed
    ..GSH(total)/GSSG ratio was restored to the control value. This study suggests that following the changes in antioxidant defense systems thiram can act through the production of free radicals...
  85. Kaminska J, Klimczak Jajor E, Skierski J, Bany Laszewicz U. Effects of inhibitor of Src kinases, SU6656, on differentiation of megakaryocytic progenitors and activity of alpha1,6-fucosyltransferase. Acta Biochim Pol. 2008;55:499-506 pubmed
    ..We suggest FUT8 as a candidate for an early marker of differentiation and possibly of the ploidy level of Mks. We confirm a special status of FUT8 in megakaryocytopoiesis. ..
  86. Gizak A, Zarzycki M, Rakus D. Nuclear targeting of FBPase in HL-1 cells is controlled by beta-1 adrenergic receptor-activated Gs protein signaling cascade. Biochim Biophys Acta. 2009;1793:871-7 pubmed publisher
  87. Frackowiak A, Skibiński P, Gaweł W, Zaczynska E, Czarny A, Gancarz R. Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compounds in kidney stone therapy. Eur J Med Chem. 2010;45:1001-7 pubmed publisher
    ..In addition, the effect of the compounds obtained on real kidney stones was analyzed by ex vivo tests. The tests on L929 and A545 cell lines have shown that the compounds obtained were not cytotoxic...
  88. Jozwiak K, Toll L, Jimenez L, Woo A, Xiao R, Wainer I. The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the beta(2)-adrenoceptor. Biochem Pharmacol. 2010;79:1610-5 pubmed publisher
    ..When the configuration at the beta-OH carbon is S the binding process is enthalpy-driven while the R configuration produces an entropy-driven process. ..
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    ..Thus, degradation of matrin 3 may be a switching event that induces a shift from apoptotic to necrotic death of cells. ..
  90. Witusik M, Gresner S, Hulas Bigoszewska K, Krynska B, Azizi S, Liberski P, et al. Neuronal and astrocytic cells, obtained after differentiation of human neural GFAP-positive progenitors, present heterogeneous expression of PrPc. Brain Res. 2007;1186:65-73 pubmed
    ..Of note, glial and neuronal cells showed a very large heterogeneity of PrP(c) expression. Our results provide the basis for studying the role of PrP(c) in cell differentiation and neurogenesis from human GFAP-positive progenitor cells. ..