Genomes and Genes
Experts and Doctors on cell division in United States
Locale: United States
Topic: cell division
Publications409 found, 100 shown here
- Bianco N, Montano M. Regulation of prothymosin alpha by estrogen receptor alpha: molecular mechanisms and relevance in estrogen-mediated breast cell growth. Oncogene. 2002;21:5233-44 pubmed..Overall these studies underscore the importance of PTalpha in estrogen-induced breast cell proliferation. ..
- Brown W, Skeiky Y, Probst P, Rockey D. Chlamydial antigens colocalize within IncA-laden fibers extending from the inclusion membrane into the host cytosol. Infect Immun. 2002;70:5860-4 pubmed..This colocalization may explain how chlamydial developmental form antigens are localized outside of the inclusion within infected cells. ..
- Martens E, Heungens K, Goodrich Blair H. Early colonization events in the mutualistic association between Steinernema carpocapsae nematodes and Xenorhabdus nematophila bacteria. J Bacteriol. 2003;185:3147-54 pubmed..nematophila in its host niche, and will facilitate interpretation of future data regarding the molecular events mediating this process...
- Ambros V. MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell. 2003;113:673-6 pubmed..In C. elegans, a homolog of the well-known fly developmental regulator hunchback acts downstream of the microRNAs lin-4 and let-7 in a pathway controlling developmental timing. ..
- Deng X, Mercer S, Shah S, Ewton D, Friedman E. The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase. J Biol Chem. 2004;279:22498-504 pubmed..In addition, depletion of Mirk by RNA(i) in postmitotic C2C12 myoblasts decreased protein but not mRNA levels of p27, suggesting that stabilization of p27 by Mirk also occurs during differentiation. ..
- Schmitt J, Wayman G, Nozaki N, Soderling T. Calcium activation of ERK mediated by calmodulin kinase I. J Biol Chem. 2004;279:24064-72 pubmed..These data are the first to suggest that ERK activation and neurite outgrowth in response to depolarization are mediated by CaMKK activation of CaMKI. ..
- Chae S, Proia R, Hla T. Constitutive expression of the S1P1 receptor in adult tissues. Prostaglandins Other Lipid Mediat. 2004;73:141-50 pubmed..We show that S1P1 is widely expressed in various cell types of adult mouse tissues, suggesting a regulatory role of this receptor in numerous physiological processes in both vascular and non-vascular tissues. ..
- Caldas H, Holloway M, Hall B, Qualman S, Altura R. Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo. J Med Genet. 2006;43:119-28 pubmed..05). Our findings support a role for Survivin in rhabdomyosarcoma biology and provide preliminary evidence for the therapeutic use of Survivin-targeted RNA interference for human tumours that express high levels of this molecule. ..
- Wu M, Herman M. Asymmetric localizations of LIN-17/Fz and MIG-5/Dsh are involved in the asymmetric B cell division in C. elegans. Dev Biol. 2007;303:650-62 pubmed..Functions of the MIG-5 DEP, PDZ and DIX domains were also conserved. Thus, a novel PCP-like pathway, in which LIN-17 and MIG-5 are asymmetrically localized, is involved in the regulation of B cell polarity. ..
- Chen C, Johnston T, Jeon H, Gedaly R, McHugh P, Ranjan D. Cyclosporine promotes epstein-barr virus-infected human B-cell transformation assayed by three correlated assay methods. Transplant Proc. 2009;41:366-70 pubmed publisher..05). In conclusion, CsA promoted EBV-B-cell transformation in three correlated assay methods in vitro using a model of posttransplant lymphoproliferative disorder...
- Renner L, Weibel D. Cardiolipin microdomains localize to negatively curved regions of Escherichia coli membranes. Proc Natl Acad Sci U S A. 2011;108:6264-9 pubmed publisher..These studies demonstrate the curvature dependence of CL in membranes and test whether these structures participate in the localization of MinD to regions of negative curvature in cells. ..
- Kausar H, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh I, et al. Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells. Cancer Lett. 2012;325:54-62 pubmed publisher..Our results thus demonstrate therapeutic potential of berries rich in this mixture of diverse anthocyanidins for non-small-cell lung cancer treatment and to prevent its future recurrence and metastasis. ..
- Howell M, Aliashkevich A, Salisbury A, Cava F, Bowman G, Brown P. Absence of the Polar Organizing Protein PopZ Results in Reduced and Asymmetric Cell Division in Agrobacterium tumefaciens. J Bacteriol. 2017;199: pubmed publisher..Finally, since many closely related plant and animal pathogens exhibit polar growth, discoveries in A. tumefaciens may be broadly applicable for devising antimicrobial strategies. ..
- Cook P, Mattox P, Keeble W, Pittelkow M, Plowman G, Shoyab M, et al. A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. Mol Cell Biol. 1991;11:2547-57 pubmed..Our present study demonstrates that one of the growth factors responsible for this autocrine growth (KAF) is similar or identical to AR and that KAF and AR bioactivity can be negatively regulated by heparin sulfate. ..
- Lutkenhaus J. Regulation of cell division in E. coli. Trends Genet. 1990;6:22-5 pubmed..The activity of this protein is channelled to the new division site by the activity of the min locus, which blocks access to old sites. Continued study of these genes should yield further insights into the cell division process. ..
- Gottardis M, Ricchio M, Satyaswaroop P, Jordan V. Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa101) in athymic mice. Cancer Res. 1990;50:3189-92 pubmed..Thus these compounds or derivatives may prove useful as a second-line endocrine therapy should TAM-stimulated tumor growth occur in the clinic...
- Messick J, Rikihisa Y. Characterization of Ehrlichia risticii binding, internalization, and proliferation in host cells by flow cytometry. Infect Immun. 1993;61:3803-10 pubmed..Although E. risticii did not bind to the surface of equine PMN leukocytes at 4 degrees C, organisms were taken up by this cell at 37 degrees C. E. risticii, however, failed to survive in equine PMN leukocytes...
- Khosla S, Hassoun A, Baker B, Liu F, Zein N, Whyte M, et al. Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults. J Clin Invest. 1998;101:2165-73 pubmed..Our findings in HCAO suggest a possible means to increase bone mass in patients with osteoporosis...
- Zhang Q, Peyruchaud O, French K, Magnusson M, Mosher D. Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway. Blood. 1999;93:2984-90 pubmed..These results indicate a common signal pathway leading to control of cellular fibronectin matrix assembly by bioactive lipids generated during blood coagulation. ..
- Pedersen L, Angert E, Setlow P. Septal localization of penicillin-binding protein 1 in Bacillus subtilis. J Bacteriol. 1999;181:3201-11 pubmed..subtilis. This is the first example of a high-molecular-weight class A PBP that is localized to the bacterial division septum. ..
- Damon D. NGF-independent survival of postganglionic sympathetic neurons in neuronal-vascular smooth muscle cocultures. Am J Physiol Heart Circ Physiol. 2001;280:H1722-8 pubmed..The data also indicate that endothelin contributes to this effect and suggest that endothelin as well as other VSM-derived factors may play a role in the development of sympathetic innervation to the vasculature...
- Ardelt B, Kunicki J, Traganos F, Darzynkiewicz Z. Chlorophyllin protects cells from the cytostatic and cytotoxic effects of quinacrine mustard but not of nitrogen mustard. Int J Oncol. 2001;18:849-53 pubmed..Therefore, excess of chlorophyll in the diet, by sequestering aromatic mutagens (or antitumor drugs with a heterocyclic structure, if taken orally), may inhibit their accessibility to cells, thereby reducing their activity. ..
- Dong F, Gutkind J, Larner A. Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival. J Biol Chem. 2001;276:10811-6 pubmed..Together, these data implicate Erk5 as an important signaling component in the biological actions of G-CSF. ..
- Downs K, Temkin R, Gifford S, McHugh J. Study of the murine allantois by allantoic explants. Dev Biol. 2001;233:347-64 pubmed
- Xiao H, Yin T, Wang X, Uchida T, Chung J, White M, et al. Specificity of interleukin-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway. J Biol Chem. 2002;277:8091-8 pubmed..These data suggest that IRS-dependent signaling pathways work by recruiting different signaling molecules to determine specificity of IL-2R gamma superfamily cytokines. ..
- Morgan E, Nguyen S, Scott V, Stadler H. Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia. Development. 2003;130:3095-109 pubmed..Finally, a novel role for Hoxa13 in the vascularization of the glans penis is also identified. ..
- Yamane K, Chen J, Kinsella T. Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. Cancer Res. 2003;63:3049-53 pubmed..These results indicate that both TopBP1 and BRCA1 specifically regulate the G(2)-M checkpoint, partially compensating each function. ..
- Grantham J. Lillian Jean Kaplan International Prize for advancement in the understanding of polycystic kidney disease. Understanding polycystic kidney disease: a systems biology approach. Kidney Int. 2003;64:1157-62 pubmed
- Sah J, Balasubramanian S, Eckert R, Rorke E. Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases. J Biol Chem. 2004;279:12755-62 pubmed..Importantly, the EGCG inhibition is selective, as EGCG does not effect the EGFR-dependent activation of JNK. These results suggest that EGCG acts to selectively inhibit multiple EGF-dependent kinases to inhibit cell proliferation. ..
- Bao L, Kimzey A, Sauter G, Sowadski J, Lu K, Wang D. Prevalent overexpression of prolyl isomerase Pin1 in human cancers. Am J Pathol. 2004;164:1727-37 pubmed
- Curtin J, Spinella M. p53 in human embryonal carcinoma: identification of a transferable, transcriptional repression domain in the N-terminal region of p53. Oncogene. 2005;24:1481-90 pubmed..These data indicate that a unique repressor domain resides in p53 at residues 90-116 whose activity can be modulated in the presence of 'differentiation therapy' and 'transcription therapy' agents...
- Donnelly C, Olsen A, Lewis L, Eisenberg B, Eastman A, Kinlaw W. Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells. Nutr Cancer. 2009;61:114-22 pubmed publisher..Rescue from the antiproliferative effect of CLA by palmitic acid indicates that reduced tumor lipogenesis is a major mechanism for the anticancer effects of CLA. ..
- Yang X, Wood P, Hrushesky W. Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control. J Biol Chem. 2010;285:3030-4 pubmed publisher..TIM is, thereby, a potential novel anticancer drug target whose inhibition may enhance the therapeutic cytotoxicity of agents that activate DNA damage pathways as part of their mechanism. ..
- Wuerzberger Davis S, Chen Y, Yang D, Kearns J, Bates P, Lynch C, et al. Nuclear export of the NF-?B inhibitor I?B? is required for proper B cell and secondary lymphoid tissue formation. Immunity. 2011;34:188-200 pubmed publisher..Thus, I?B? nuclear export is essential to maintain constitutive, canonical, and noncanonical NF-?B activation potentials in mature B cells in vivo...
- Lobikin M, Wang G, Xu J, Hsieh Y, Chuang C, Lemire J, et al. Early, nonciliary role for microtubule proteins in left-right patterning is conserved across kingdoms. Proc Natl Acad Sci U S A. 2012;109:12586-91 pubmed publisher..The origin of laterality is cytoplasmic, ancient, and highly conserved across kingdoms, a fundamental feature of the cytoskeleton that underlies chirality in cells and multicellular organisms...
- Ishikawa H, Carrasco D, Claudio E, Ryseck R, Bravo R. Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2. J Exp Med. 1997;186:999-1014 pubmed..Thus, the p100 precursor is essential for the proper regulation of p52-containing Rel/NF-kappaB complexes in various cell types and its absence cannot be efficiently compensated for by other IkappaB proteins. ..
- Corjay M, Kearney M, Munzer D, Diamond S, Stoltenborg J. Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human. Lab Invest. 1998;78:847-58 pubmed..Taken together, these data underscore a potentially important role for BTG1 in regulating the cellularity of advanced atherosclerotic lesions. ..
- Lairmore M, Stanley J, Weber S, Holzschu D. Squamous epithelial proliferation induced by walleye dermal sarcoma retrovirus cyclin in transgenic mice. Proc Natl Acad Sci U S A. 2000;97:6114-9 pubmed
- Cen D, Gonzalez R, Buckmeier J, Kahlon R, Tohidian N, Meyskens F. Disulfiram induces apoptosis in human melanoma cells: a redox-related process. Mol Cancer Ther. 2002;1:197-204 pubmed..Our findings have provided new data for additional understanding of drug-induced apoptosis in melanoma cells and suggests an alternative therapeutic approach to melanoma...
- Johnson T, Vue M, Brekhus S, Khong A, Ho T, Walker A. Unmodified prolactin (PRL) promotes PRL secretion and acidophil hypertrophy and is associated with pituitary hyperplasia in female rats. Endocrine. 2003;20:101-10 pubmed..that U-PRL and P-PRL may also have differential roles in the regulation of pituitary cell proliferation...
- Agarwal A, Munoz Najar U, Klueh U, Shih S, Claffey K. N-acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer. Am J Pathol. 2004;164:1683-96 pubmed..These results suggest that systemic NAC therapy promotes anti-angiogenesis through angiostatin production, resulting in endothelial apoptosis and vascular collapse in the tumor. ..
- Yeh Y, Lin C, Chen T. Human IGF-I Eb-peptide induces cell attachment and lamellipodia outspread of metastatic breast carcinoma cells (MDA-MB-231). Exp Cell Res. 2017;358:199-208 pubmed publisher..With the highly purified hEb-peptide, not only could we study its function(s) in detail but also the minimum requirement for cancerous cells to metastasize to a suitable environment and grow. ..
- Culouscou J, Shoyab M. Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein. Cancer Res. 1991;51:2813-9 pubmed..The monoclonal antibody alpha IR-3 is known to block the mitogenic actions of IGFs. alpha IR-3 inhibited the growth of HT29 cells, thus suggesting that IGFs are required for the growth of these colon cancer cells. ..
- Anderson D, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, et al. Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J Biol Chem. 1995;270:29862-9 pubmed..However, the distribution of expression of the IL-15R alpha is much wider than that of the IL-2R alpha, suggesting a broader range of cellular targets for IL-15. ..
- Snapka R, Ge S, Trask J, Robertson F. Unbalanced growth in mouse cells with amplified dhfr genes. Cell Prolif. 1997;30:385-99 pubmed
- Hong Y, Roy R, Ambros V. Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans. Development. 1998;125:3585-97 pubmed..In vulva precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 stage. ..
- Cho J, Sagartz J, Capen C, Mazzaferri E, Jhiang S. Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice. Oncogene. 1999;18:3659-65 pubmed..These findings provide a model for the role of RET/PTC1 in the formation of abnormal follicles with reduced iodide uptake ability observed in human papillary thyroid carcinoma. ..
- Badrinath A, White J. Contrasting patterns of mitochondrial redistribution in the early lineages of Caenorhabditis elegans and Acrobeloides sp. PS1146. Dev Biol. 2003;258:70-5 pubmed..In both species, the location of the mitochondria immediately prior to cell division correlates with the known location of the germline determinants, P granules, leading us to speculate that they may be associated. ..
- Frohnert P, Stonecypher M, Carroll S. Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line. Glia. 2003;43:104-18 pubmed..The absence of EGFR expression in JS1 cells suggests that constitutive activation of the NRG-1/erbB signaling pathway is an alternative means of inducing Schwann cell neoplasia. ..
- Nguyen K, Hu X, Colton C, Chakrabarti R, Zhu M, Pei D. Characterization of a human peptide deformylase: implications for antibacterial drug design. Biochemistry. 2003;42:9952-8 pubmed..These results suggest that HsPDF is likely an evolutional remnant without any functional role in protein formylation/deformylation and validates PDF as an excellent target for antibacterial drug design. ..
- Kotadia B, Ravindranath T, Choudhry M, Haque F, Al Ghoul W, Sayeed M. Effects of pentoxyfylline on mesenteric lymph node T-cells in a rat model of thermal injury. Shock. 2003;20:517-20 pubmed..These findings altogether suggested that PTX treatment attenuate T cell suppression in burn-injured rats and that the effects of PTX are mediated via modulating P59 fyn and Ca2+ signaling. ..
- Dombrink Kurtzman M. Fumonisin and beauvericin induce apoptosis in turkey peripheral blood lymphocytes. Mycopathologia. 2003;156:357-64 pubmed..Tricarballylic acid and moniliformin did not interfere with cell proliferation. Results suggested that fumonisin B1 and beauvericin may affect immune functions by suppressing proliferation and inducing apoptosis of lymphocytes. ..
- Tam B, Moritz O, Papermaster D. The C terminus of peripherin/rds participates in rod outer segment targeting and alignment of disk incisures. Mol Biol Cell. 2004;15:2027-37 pubmed..This work describes novel roles for the C terminus of peripherin/rds in targeting and maintaining ROS structure and its potential involvement in inherited retinal degenerations. ..
- Viollier P, Shapiro L. Spatial complexity of mechanisms controlling a bacterial cell cycle. Curr Opin Microbiol. 2004;7:572-8 pubmed
- Myers T, Nickerson C, Kaushal D, Ott C, Honer zu Bentrup K, Ramamurthy R, et al. Closing the phenotypic gap between transformed neuronal cell lines in culture and untransformed neurons. J Neurosci Methods. 2008;174:31-41 pubmed publisher..These results demonstrate that a 3D culture approach narrows the phenotypic gap between neuronal cell lines and primary neurons. The resulting cells may readily be used for in vitro research of neuronal pathogenesis. ..
- Loganathan R, Lee J, Wells M, GREVENGOED E, Slattery M, Andrew D. Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression. Dev Biol. 2016;409:234-250 pubmed publisher..Furthermore, our results suggest that autoregulation of rib expression may be a key component of the SG morphogenetic gene network. ..
- de Boer P, Crossley R, Rothfield L. Isolation and properties of minB, a complex genetic locus involved in correct placement of the division site in Escherichia coli. J Bacteriol. 1988;170:2106-12 pubmed..The results indicate that minB is a complex locus whose expression must be maintained within certain limits to maintain the normal pattern of localization of the division septum. ..
- Zhou Y, Kusukawa N, Erickson J, Gross C, Yura T. Isolation and characterization of Escherichia coli mutants that lack the heat shock sigma factor sigma 32. J Bacteriol. 1988;170:3640-9 pubmed..Several heat shock proteins are synthesized in the absence of sigma 32, indicating that there are additional mechanisms controlling the synthesis of some heat shock proteins. ..
- Lopez I, McKay D. Effects of antimitotic agents on secretion and detergent extractibility of adrenal nicotinic acetylcholine receptors. Cell Mol Neurobiol. 1997;17:447-54 pubmed
- O Connell K, Leys C, White J. A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans. Genetics. 1998;149:1303-21 pubmed..We conclude that this approach can be used to identify mutations that affect various aspects of the cell-division cycle. ..
- Bikah G, Lynd F, Aruffo A, Ledbetter J, Bondada S. A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5. Int Immunol. 1998;10:1185-96 pubmed..CD5L was expressed on activated splenic B cells, but not T cells, whereas its expression was constitutive on peritoneal B cells and on B lymphoma cell lines. ..
- Li H, Wu G, Ware D, Davis K, Yang Z. Arabidopsis Rho-related GTPases: differential gene expression in pollen and polar localization in fission yeast. Plant Physiol. 1998;118:407-17 pubmed..We propose that Rop1At may play a predominant role in the regulation of polarized cell growth in pollen, whereas its close relatives Rop3At and Rop5At may be functionally redundant to Rop1At in pollen. ..
- Jacobsen S, Running M, Meyerowitz E. Disruption of an RNA helicase/RNAse III gene in Arabidopsis causes unregulated cell division in floral meristems. Development. 1999;126:5231-43 pubmed..Thus CAF may act through some type of RNA processing event(s). CAF gives rise to two major transcripts of 2.5 and 6.2 kb. In situ hybridization experiments show that CAF RNA is expressed throughout all shoot tissues. ..
- Weng L, Smith W, Dahia P, Ziebold U, Gil E, Lees J, et al. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. Cancer Res. 1999;59:5808-14 pubmed..Therefore, PTEN appears to suppress breast cancer growth through down-regulating PI3K signaling, which leads to the blockage of cell cycle progression and the induction of cell death, in a sequential manner. ..
- Striepen B, Crawford M, Shaw M, Tilney L, Seeber F, Roos D. The plastid of Toxoplasma gondii is divided by association with the centrosomes. J Cell Biol. 2000;151:1423-34 pubmed..These observations are discussed in the context of autonomous and FtsZ-dependent division of plastids in plants and algae. ..
- Silverman R, Halloum A, Zhou A, Dong B, Al Zoghaibi F, Kushner D, et al. Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1. Cancer Res. 2002;62:397-402 pubmed..These data suggest that the up-regulation of PLSCR1 expression in tumor cells exposed to IFN may contribute to the observed tumor-suppressive action of this cytokine. ..
- Blumenthal R, Reising A, Leon E, Goldenberg D. Modulation of marrow proliferation and chemosensitivity by tumor-produced cytokines from syngeneic pancreatic tumor lines. Clin Cancer Res. 2002;8:1301-9 pubmed..Tumor-produced cytokines can affect marrow proliferative activity and, thus, chemosensitivity to three distinct classes of chemotherapeutics. ..
- Chu J, Dolnick B. Natural antisense (rTSalpha) RNA induces site-specific cleavage of thymidylate synthase mRNA. Biochim Biophys Acta. 2002;1587:183-93 pubmed..These data demonstrate that rTS gene expression likely plays a role in down-regulating TS through a natural RNA-based antisense mechanism. ..
- Kou H, Irvin J, Huisinga K, Mitra M, Pugh B. Structural and functional analysis of mutations along the crystallographic dimer interface of the yeast TATA binding protein. Mol Cell Biol. 2003;23:3186-201 pubmed..These phenotypes cannot be accounted for by defective interactions with other known TBP inhibitors and likely reflect defects in TBP dimerization. ..
- Cao Y, Zhao Z, Gruszczynska Biegala J, Zolkiewska A. Role of metalloprotease disintegrin ADAM12 in determination of quiescent reserve cells during myogenic differentiation in vitro. Mol Cell Biol. 2003;23:6725-38 pubmed..Our results suggest that ADAM12-mediated adhesion and/or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation. ..
- Moissoglu K, Gelman I. v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts. J Biol Chem. 2003;278:47946-59 pubmed..Overall, our data indicate that FAK, although dispensable, attenuates v-Src-induced oncogenic transformation by modulating distinct signaling and cytoskeletal pathways. ..
- Warheit D, Laurence B, Reed K, Roach D, Reynolds G, Webb T. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci. 2004;77:117-25 pubmed..Thus, the physiological relevance of these findings should ultimately be determined by conducting an inhalation toxicity study...
- Clark K, Oelke A, Johnson M, Eilert K, Simpson P, Todd S. CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner. J Biol Chem. 2004;279:19401-6 pubmed..These finding suggest that CD81 signaling events could be mediated by 14-3-3 adapter proteins, and these signals may be dependent on cellular redox. ..
- Vitiello P, Shainheit M, Allison E, Adler E, Kurt R. Impact of tumor-derived CCL2 on T cell effector function. Immunol Lett. 2004;91:239-45 pubmed..Collectively, these data indicate that tumor-derived CCL2 could decrease T cell effector function, yet not the overall immunogenicity of the tumor. ..
- Ursic D, Chinchilla K, Finkel J, Culbertson M. Multiple protein/protein and protein/RNA interactions suggest roles for yeast DNA/RNA helicase Sen1p in transcription, transcription-coupled DNA repair and RNA processing. Nucleic Acids Res. 2004;32:2441-52 pubmed..The protein-protein and protein-RNA interactions reported here suggest that the DNA/RNA helicase activity of Sen1p is utilized for several different purposes in multiple gene expression pathways. ..
- Bernhardt T, de Boer P. Screening for synthetic lethal mutants in Escherichia coli and identification of EnvC (YibP) as a periplasmic septal ring factor with murein hydrolase activity. Mol Microbiol. 2004;52:1255-69 pubmed..By uncovering genetic interactions, the synthetic lethal screen described here provides an attractive new tool for studying gene function in E. coli. ..
- Fisk H, Winey M. Spindle regulation: Mps1 flies into new areas. Curr Biol. 2004;14:R1058-60 pubmed..The work also contributes new additions to a list of Mps1 functions that continues to grow with each new study. ..
- Fraser M, Watson P, Fraig M, Kelley J, Nelson P, Boylan A, et al. CaSm-mediated cellular transformation is associated with altered gene expression and messenger RNA stability. Cancer Res. 2005;65:6228-36 pubmed
- Strome S, Lehmann R. Germ versus soma decisions: lessons from flies and worms. Science. 2007;316:392-3 pubmed
- Hardman W. Dietary canola oil suppressed growth of implanted MDA-MB 231 human breast tumors in nude mice. Nutr Cancer. 2007;57:177-83 pubmed..Use of canola oil instead of corn oil in the diet may be a reasonable means to increase consumption of n-3 fatty acids with potential significance for slowing growth of residual cancer cells in cancer survivors. ..
- Wang W, Zhang X, Mize G, Takayama T. Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. Prostate. 2008;68:1064-75 pubmed publisher..The expression and function of PAR-1 in BPH stroma indicate PAR-1 may play important roles in BPH pathogenesis. ..
- Gunsalus K, Wagoner M, Meyer K, Potter W, Schoenike B, Kim S, et al. Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors. Cancer Res. 2012;72:3207-16 pubmed publisher..Our findings therefore show a critical role for the REST-LIN28A axis in tumor aggression and suggest a causative relationship between REST loss and tumorigenicity in vivo. ..
- Choudhary A, Lera R, Martowicz M, Oxendine K, Laffin J, Weaver B, et al. Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis. Proc Natl Acad Sci U S A. 2013;110:13026-31 pubmed publisher..Thus, traction-mediated cytofission, originally observed in Dictyostelium, is relevant to human biology--where it seems to be an evolutionarily conserved mechanism that can preserve genomic integrity. ..
- Kerr M, Fischer J, Purushotham K, Gao D, Nakagawa Y, Maeda N, et al. Characterization of the synthesis and expression of the GTA-kinase from transformed and normal rodent cells. Biochim Biophys Acta. 1994;1218:375-87 pubmed..Western blot analysis confirmed a translocation from a cytoplasmic localization in both LSTRA and quiescent salivary cells to a membrane-associated localization in YC-8 and proliferating salivary cells. ..
- Smith L, Liu S, Goodrich L, Jacobson D, Degnin C, Bentley N, et al. Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest. Nat Genet. 1998;19:39-46 pubmed..Thus, genetic alteration of ATR leads to loss of differentiation as well as cell-cycle abnormalities. ..
- Cook T, Gebelein B, Mesa K, Mladek A, Urrutia R. Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. J Biol Chem. 1998;273:25929-36 pubmed..Thus, TIEG2, together with TIEG1, defines a new subfamily of TGF-beta-inducible Sp1-like proteins involved in the regulation of cell growth. ..
- Longley R, Woods A, Fleetwood A, Cowling G, Gallagher J, Couchman J. Control of morphology, cytoskeleton and migration by syndecan-4. J Cell Sci. 1999;112 ( Pt 20):3421-31 pubmed..The data suggest that syndecan-4 is a regulator of focal adhesion and stress fiber formation, and influences both morphology and migration. ..
- Vetvicka V, Vetvickova J, Fusek M. Role of procathepsin D activation peptide in prostate cancer growth. Prostate. 2000;44:1-7 pubmed..This interaction leads in certain types of tumor to a proliferation and higher motility. Blocking of this interaction by antibodies or antagonists might be a valuable tool in prostate cancer inhibition. ..