Experts and Doctors on cell division in Japan


Locale: Japan
Topic: cell division

Top Publications

  1. Miyazaki M, Bai L, Taga H, Hirai H, Sato J, Namba M. Expression of liver-specific functions and secretion of a hepatocyte growth factor by a newly established rat hepatoma cell line growing in a chemically-defined serum-free medium. Res Exp Med (Berl). 1991;191:297-307 pubmed
    ..These properties of the cell line 3'-mRLh-2 were compared with those of the popular rat hepatoma cell lines, such as H4-II-E-C3 from Reuber hepatoma H35 and HTC from Morris hepatoma 7288C. ..
  2. Wu C, Sakai K, Saito M, Hotta Y. Giant Drosophila neurons differentiated from cytokinesis-arrested embryonic neuroblasts. J Neurobiol. 1990;21:499-507 pubmed
    ..The cells of increased sizes in this culture system are more accessible to physiological and cell biological analyses and could facilitate future studies of the Drosophila nervous system. ..
  3. Saha A, Ueno K, Kitagawa H, Satoh T. Comparisons of heptaminol AMP amidate and dibutyryl cyclic AMP on murine splenocytes proliferation. Res Commun Chem Pathol Pharmacol. 1990;67:337-48 pubmed
    ..Both HAA and DbcAMP also inhibited the blastogenesis of spleen cells in one way mixed lymphocyte reaction...
  4. Shinohara Y, Nishida E, Sakai H. Colchicine acts as a progression factor to initiate DNA synthesis in quiescent Balb/c 3T3 cells. FEBS Lett. 1988;236:19-22 pubmed
    ..Moreover, it acted synergistically with fibroblast growth factor, another competence factor. These results suggest that colchicine acts as a progression factor like insulin in quiescent Balb/c 3T3 cells. ..
  5. Samejima I, Yanagida M. Identification of cut8+ and cek1+, a novel protein kinase gene, which complement a fission yeast mutation that blocks anaphase. Mol Cell Biol. 1994;14:6361-71 pubmed
    ..The cek1+ gene is not an essential gene. Protein phosphorylation by cek1 may facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein. ..
  6. Hirano T, Oka K, Mimaki Y, Kuroda M, Sashida Y. Potent growth inhibitory activity of a novel Ornithogalum cholestane glycoside on human cells: induction of apoptosis in promyelocytic leukemia HL-60 cells. Life Sci. 1996;58:789-98 pubmed
    ..2 nM. These results provided the first evidence ever for the potent growth inhibitory activity of Ornithogalum glycoside on human leukemia cell lines and PBMC. ..
  7. Tsumanuma I, Tanaka R, Washiyama K. Clinicopathological study of pineal parenchymal tumors: correlation between histopathological features, proliferative potential, and prognosis. Brain Tumor Pathol. 1999;16:61-8 pubmed
    ..With regard to the malignant potential, we emphasize that a clear distinction should be made between pineoblastomas in children and other types of pineal parenchymal tumors in adults...
  8. Kaula S, Reddelb R, Sugiharac T, Mitsuia Y, Wadhwac R. Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2. FEBS Lett. 2000;474:159-64 pubmed
    ..We have thus shown for the first time that overexpression of mot-2 in normal human cells is able to permit their temporary escape from senescence. ..
  9. Hirose K, Kawashima T, Iwamoto I, Nosaka T, Kitamura T. MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. J Biol Chem. 2001;276:5821-8 pubmed
    ..Furthermore, using a GAP-inactive mutant, we have shown that the GAP activity of MgcRacGAP is required for cytokinesis, suggesting that inactivation of the Rho family of GTPases may be required for normal progression of cytokinesis. ..

More Information

Publications214 found, 100 shown here

  1. Satomi H, Wang B, Fujisawa H, Otsuka F. Interferon-beta from melanoma cells suppresses the proliferations of melanoma cells in an autocrine manner. Cytokine. 2002;18:108-15 pubmed
    ..Furthermore, melanoma cells are capable of suppressing their own proliferation via secretion of endogenous IFN-beta. This finding may have important implications for melanoma therapy. ..
  2. Nagai H, Yabe A, Mine N, Mikami I, Fujiwara H, Terada Y, et al. Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growth. Cancer Lett. 2003;193:41-7 pubmed
    ..Transfection of a DRHC expression vector inhibited growth of cancer cells in liquid medium or soft agar. The results suggest that loss of expression of DRHC may play a role in human carcinogenesis. ..
  3. Takahashi T, Kamimura A, Hamazono Matsuoka T, Honda S. Phosphatidic acid has a potential to promote hair growth in vitro and in vivo, and activates mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in hair epithelial cells. J Invest Dermatol. 2003;121:448-56 pubmed
  4. Maemondo M, Saijo Y, Narumi K, Kikuchi T, Usui K, Tazawa R, et al. Gene therapy with secretory leukoprotease inhibitor promoter-controlled replication-competent adenovirus for non-small cell lung cancer. Cancer Res. 2004;64:4611-20 pubmed
    ..These results suggest that AdSLPI.E1AdB could provide a selective therapeutic modality for NSCLC and that the combination of AdSLPI.E1AdB and AdCMV.NK4 may be a more effective gene therapy for NSCLC. ..
  5. Fujii C, Nakamoto Y, Lu P, Tsuneyama K, Popivanova B, Kaneko S, et al. Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. Int J Cancer. 2005;114:209-18 pubmed
    ..These observations suggest that aberrantly expressed Pim-3 can cause autonomous cell proliferation or prevent apoptosis in hepatoma cell lines. ..
  6. Sakaguchi Y, Sekiya I, Yagishita K, Muneta T. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum. 2005;52:2521-9 pubmed
    ..Superiority of synovium as a potential source of MSCs for clinical applications was demonstrated. ..
  7. Sumita T, Yoko o T, Shimma Y, Jigami Y. Comparison of cell wall localization among Pir family proteins and functional dissection of the region required for cell wall binding and bud scar recruitment of Pir1p. Eukaryot Cell. 2005;4:1872-81 pubmed
    ..This is the first report that bud scars contain proteins like Pir1p as internal components. ..
  8. Ishikawa S, Kawai Y, Hiramatsu K, Kuwano M, Ogasawara N. A new FtsZ-interacting protein, YlmF, complements the activity of FtsA during progression of cell division in Bacillus subtilis. Mol Microbiol. 2006;60:1364-80 pubmed
    ..These results suggest that YlmF has an overlapping function with FtsA in stimulating the formation of Z rings in B. subtilis. ..
  9. Imokawa G, Yada Y, Miyagishi M. Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes. J Biol Chem. 1992;267:24675-80 pubmed
    ..These studies suggest that ETs produced and secreted by keratinocytes play an essential role in the maintenance of melanocyte proliferation and UV hyperpigmentation in the epidermis. ..
  10. Senga T, Iwamoto T, Humphrey S, Yokota T, Taparowsky E, Hamaguchi M. Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells. Oncogene. 2002;21:8186-91 pubmed
    ..These results indicate that Stat3 mediates cellular growth by modulating AP-1 activity through the induction of BATF. ..
  11. Amemiya K, Kaneko Y, Muramatsu T, Shimono M, Inoue T. Pulp cell responses during hypoxia and reoxygenation in vitro. Eur J Oral Sci. 2003;111:332-8 pubmed
    ..These results suggest that dynamic responses to hypoxia and reoxygenation occur in pulp cells. ..
  12. Ohsugi T, Horie R, Kumasaka T, Ishida A, Ishida T, Yamaguchi K, et al. In vivo antitumor activity of the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin in a mouse model of adult T-cell leukemia. Carcinogenesis. 2005;26:1382-8 pubmed
    ..These results suggest that DHMEQ induces apoptosis in HTLV-I-transformed cells in vivo, resulting in inhibition of tumor formation and organ infiltration, thereby enhancing survival. ..
  13. Morikawa K, Oseko F, Morikawa S. The role of CD45 in the activation, proliferation and differentiation of human B lymphocytes. Int J Hematol. 1991;54:495-504 pubmed
    ..These results indicated that CD45 antigen defined by T29/33 is involved in the activation, proliferation, and differentiation signals of human B lymphocytes. ..
  14. Hoshino S, Miyazawa H, Enomoto T, Hanaoka F, Kikuchi Y, Kikuchi A, et al. A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. EMBO J. 1989;8:3807-14 pubmed
    ..A possible role of GST1-Hs in mammalian cell growth is discussed. ..
  15. Terakawa N, Ikegami H, Shimizu I, Inoue M, Tanizawa O, Matsumoto K. Inhibitory effects of danazol and medroxyprogesterone acetate on [3H]thymidine incorporation in human endometrial cancer cells. J Steroid Biochem. 1988;31:131-5 pubmed
  16. Suzuki T, Sadakata Y, Kashiwagi K, Hoshino K, Kakinuma Y, Shirahata A, et al. Overproduction of S-adenosylmethionine decarboxylase in ethylglyoxal-bis(guanylhydrazone)-resistant mouse FM3A cells. Eur J Biochem. 1993;215:247-53 pubmed
    ..The variant cell line is convenient for studying the regulation of AdoMetDC and the physiological function of polyamines. ..
  17. Ueguchi C, Kakeda M, Mizuno T. Autoregulatory expression of the Escherichia coli hns gene encoding a nucleoid protein: H-NS functions as a repressor of its own transcription. Mol Gen Genet. 1993;236:171-8 pubmed
    ..These results support the view that the nucleoid protein, H-NS, can function as a transcriptional regulator. ..
  18. Akagi M, Yasui W, Akama Y, Yokozaki H, Tahara H, Haruma K, et al. Inhibition of cell growth by transforming growth factor beta 1 is associated with p53-independent induction of p21 in gastric carcinoma cells. Jpn J Cancer Res. 1996;87:377-84 pubmed
    ..These results suggest that the growth inhibition of tumor cells by TGFbeta 1 is associated with p53-independent induction of p21, subsequent suppression of cdk activity and a decrease in cyclin A protein in TMK-1 cells. ..
  19. Nishizumi H, Yamamoto T. Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells. J Immunol. 1997;158:2350-5 pubmed
    ..Our data suggest that the activity of the other Src family kinases, such as c-Src, can complement the role of Lyn in inducing most, but not all, biologic and biochemical responses to Fc epsilon RI cross-linking. ..
  20. Kobayashi M, Asai Y, Hatakeyama K, Kijima N, Wachi M, Nagai K, et al. Cloning, sequencing, and characterization of the ftsZ gene from coryneform bacteria. Biochem Biophys Res Commun. 1997;236:383-8 pubmed publisher
    ..Expression of Br. flavum ftsZ gene in E. coli, JM109 inhibited its cell division, leading to filamentation. This suggested that the Br. flavum ftsZ product competed with the E. coli ftsZ product...
  21. Madaule P, Eda M, Watanabe N, Fujisawa K, Matsuoka T, Bito H, et al. Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature. 1998;394:491-4 pubmed
    ..We propose that citron kinase regulates cytokinesis at a step after Rho in the contractile process. ..
  22. Fujimoto K, Hosotani R, Doi R, Wada M, Lee J, Koshiba T, et al. Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells. Int J Cancer. 1999;81:637-44 pubmed
    ..TAC-101 may therefore be a useful agent for new therapeutic strategies focusing on inhibition of pancreatic-cancer-cell proliferation. ..
  23. Li Z, Shiota K. Stage-specific homeotic vertebral transformations in mouse fetuses induced by maternal hyperthermia during somitogenesis. Dev Dyn. 1999;216:336-48 pubmed
  24. Emoto M, Ishiguro M, Iwasaki H, Kikuchi M, Kawarabayashi T. TNP-470 inhibits growth and the production of vascular endothelial growth factor of uterine carcinosarcoma cells in vitro. Anticancer Res. 2000;20:601-4 pubmed
    ..However, further in vivo experimental studies using TNP-470 for this tumor will be necessary before any definitive conclusions can be made. ..
  25. Nomura K, Nakamura H, Suzuki N. False fertilization in sea urchin eggs induced by diabolin, a 120K kelp protein. Biochem Biophys Res Commun. 2000;272:691-3 pubmed
    ..A question was left to be solved as to how the kelp on the southeast coast of Hokkaido Island could develop the defense mechanism against the sea urchin on Honshu Island separated by Tsugaru Straits. ..
  26. Hirota A, Taki S, Kawaii S, Yano M, Abe N. 1,1-Diphenyl-2-picrylhydrazyl radical-scavenging compounds from soybean miso and antiproliferative activity of isoflavones from soybean miso toward the cancer cell lines. Biosci Biotechnol Biochem. 2000;64:1038-40 pubmed
    ..The antiproliferative activity of four of the isolated isoflavones toward three cancer cell lines was examined. 8-Hydroxygenistein showed the highest activity (IC50=5.2 microM) toward human promyelocytic leukemia cells (HL-60). ..
  27. Yamada K, Mizutani T, Shou Z, Yazawa T, Sekiguchi T, Yoshino M, et al. Cloning and functional expression of an E box-binding protein from rat granulosa cells. Biol Reprod. 2001;64:1315-9 pubmed
    ..Thus, we report molecular cloning, expression, and functional characterization of full-length rat USF2 cDNA. ..
  28. Maeda Y, Shiratsuchi A, Namiki M, Nakanishi Y. Inhibition of sperm production in mice by annexin V microinjected into seminiferous tubules: possible etiology of phagocytic clearance of apoptotic spermatogenic cells and male infertility. Cell Death Differ. 2002;9:742-9 pubmed
    ..This suggests that the elimination of apoptotic spermatogenic cells is required for the production of sperm...
  29. Miyoshi K, Shirai C, Mizuta K. Transcription of genes encoding trans-acting factors required for rRNA maturation/ribosomal subunit assembly is coordinately regulated with ribosomal protein genes and involves Rap1 in Saccharomyces cerevisiae. Nucleic Acids Res. 2003;31:1969-73 pubmed
  30. Kominami R, Yasutaka S, Taniguchi Y, Shinohara H. Proliferating cells in the rat anterior pituitary during the postnatal period: immunoelectron microscopic observations using monoclonal anti-bromodeoxyuridine antibody. Histochem Cell Biol. 2003;120:223-33 pubmed
    ..These results suggest: (1) the majority of proliferating cells were mature cells producing anterior pituitary hormone(s) and (2) most of the agranular proliferating cells maybe FS cells. The possibility of the latter is discussed. ..
  31. Nakamura K, Nonaka H, Saito H, Tanaka M, Miyajima A. Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice. Hepatology. 2004;39:635-44 pubmed
    ..In conclusion, OSM and its signaling pathway may provide a useful therapeutic target for liver regeneration. ..
  32. Yudoh K, Nguyen v, Nakamura H, Hongo Masuko K, Kato T, Nishioka K. Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function. Arthritis Res Ther. 2005;7:R380-91 pubmed
    ..New efforts to prevent the development and progression of OA may include strategies and interventions aimed at reducing oxidative damage in articular cartilage. ..
  33. Funaba M, Nakaya K, Ikeda T, Murakami M, Tsuchida K, Sugino H. Requirement of Smad3 for mast cell growth. Cell Immunol. 2006;240:47-52 pubmed
  34. Iida H, Ota S, Inouye I. Cleavage, incomplete inversion, and cytoplasmic bridges in Gonium pectorale (Volvocales, Chlorophyta). J Plant Res. 2013;126:699-707 pubmed publisher
    ..Cytoplasmic bridges and cortical microtubules in G. pectorale suggest that a mechanism of kinesin-microtubule machinery similar to that in other volvocine algae is responsible for inversion in this species. ..
  35. Asano M, Furukawa K, Kido M, Matsumoto S, Umesaki Y, Kochibe N, et al. Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells. EMBO J. 1997;16:1850-7 pubmed
    ..These observations suggest that GalT plays critical roles in the regulation of proliferation and differentiation of epithelial cells after birth, although this enzyme is dispensable during embryonic development. ..
  36. Nishikori T, Ochi M, Uchio Y, Maniwa S, Kataoka H, Kawasaki K, et al. Effects of low-intensity pulsed ultrasound on proliferation and chondroitin sulfate synthesis of cultured chondrocytes embedded in Atelocollagen gel. J Biomed Mater Res. 2002;59:201-6 pubmed
    ..In this three-dimensional culture model, these results suggest that US exposure may be clinically useful in improving the quality of chondrocyte-Atelocollagen implants for transplantation into articular cartilage defects. ..
  37. Matsumoto K, Ishikawa H, Nishimura D, Hamasaki K, Nakao K, Eguchi K. Antiangiogenic property of pigment epithelium-derived factor in hepatocellular carcinoma. Hepatology. 2004;40:252-9 pubmed
    ..Reduction of serum PEDF concentration associated with the development of chronic liver diseases may contribute to the progression of HCC. In addition, gene therapy using PEDF may provide an efficient treatment for HCC. ..
  38. Yamane A, Seetharam L, Yamaguchi S, Gotoh N, Takahashi T, Neufeld G, et al. A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1). Oncogene. 1994;9:2683-90 pubmed
    ..Therefore two reciprocal communication systems, VEGF-Flt receptor family and HGF-Met receptor, may exist in hepatic tissue. ..
  39. Moon B, Yoshida T, Shiiba M, Nakao K, Katsuki M, Takaki S, et al. Functional dissection of the cytoplasmic subregions of the interleukin-5 receptor alpha chain in growth and immunoglobulin G1 switch recombination of B cells. Immunology. 2001;102:289-300 pubmed
    ..Thus, this present approach offers new insights into the functions of the cytoplasmic subregions of IL-5Ralpha, in particular its carboxy-terminal region. ..
  40. Koga H, Matsui S, Hirota T, Takebayashi S, Okumura K, Saya H. A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes. Oncogene. 1999;18:3799-809 pubmed
    ..These observations suggest that h-l(3)mbt protein has functions distinct from those of PcG proteins and may play a role in proper progression of cell division. ..
  41. Shinagawa T, Nomura T, Colmenares C, Ohira M, Nakagawara A, Ishii S. Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice. Oncogene. 2001;20:8100-8 pubmed
    ..Human c-ski gene was mapped to a region close to the p73 tumor suppressor gene at the 1p36.3 locus, which is already known to contain multiple uncharacterized tumor suppressor genes. ..
  42. Seki N, Hashimoto N, Sano H, Horiuchi S, Yagui K, Makino H, et al. Mechanisms involved in the stimulatory effect of advanced glycation end products on growth of rat aortic smooth muscle cells. Metabolism. 2003;52:1558-63 pubmed
    ..As pathways involving AGE-galectin-3 interaction thus may be involved in macroangiopathy, AGE appears to be important to the role of SMC in accelerated atherosclerosis associated with diabetes mellitus. ..
  43. Yao Z, Nakamura H, Masuko Hongo K, Suzuki Kurokawa M, Nishioka K, Kato T. Characterisation of cartilage intermediate layer protein (CILP)-induced arthropathy in mice. Ann Rheum Dis. 2004;63:252-8 pubmed
    ..An immune response to putative murine CILP/NTPPH may be involved in the ectopic calcifications in the arthritic mice. ..
  44. Shima Y, Kengaku M, Hirano T, Takeichi M, Uemura T. Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin. Dev Cell. 2004;7:205-16 pubmed
    ..Based on these findings, we discuss how Celsr2 may regulate dendritic maintenance and growth. ..
  45. Kawakami K, Ito K, Nakamura Y. Differential regulation of two genes encoding lysyl-tRNA synthetases in Escherichia coli: lysU-constitutive mutations compensate for a lysS null mutation. Mol Microbiol. 1992;6:1739-45 pubmed
    ..Furthermore, deletion mutations created immediately upstream of the lysU promoter restored growth of lysS1. These results suggest that transcription of lysU is negatively controlled by a cis-element located upstream of the promoter. ..
  46. Jia G, Tohyama C, Sone H. DNA damage triggers imbalance of proliferation and apoptosis during development of preneoplastic foci in the liver of Long-Evans Cinnamon rats. Int J Oncol. 2002;21:755-61 pubmed
    ..These findings suggest that DNA damage, reflected in DNA strand breaks, plays a critical role in the development of hepatocellular preneoplastic foci, with an imbalance between high proliferation and relatively low apoptosis. ..
  47. Sasagawa K, Matsudo Y, Kang M, Fujimura L, Iitsuka Y, Okada S, et al. Identification of Nd1, a novel murine kelch family protein, involved in stabilization of actin filaments. J Biol Chem. 2002;277:44140-6 pubmed
    ..These data suggest that Nd1-L functions as a stabilizer of actin filaments as an actin-binding protein and may play a role in the dynamic organization of the actin cytoskeleton. ..
  48. Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, et al. Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev. 2003;17:2436-49 pubmed
    ..Our findings provide a new pathogenetic model of RA and suggest that Synoviolin/Hrd1 could be targeted as a therapeutic strategy for RA...
  49. Otake K, Omoto S, Yamamoto T, Okuyama H, Okada H, Okada N, et al. HIV-1 Nef protein in the nucleus influences adipogenesis as well as viral transcription through the peroxisome proliferator-activated receptors. AIDS. 2004;18:189-98 pubmed
    ..Nef may be involved in both viral replication and the wasting syndrome associated with AIDS. ..
  50. Saito H, Inui K. Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2. Am J Physiol. 1993;265:G289-94 pubmed
    ..These findings suggest not only that dipeptide transporters exist on both the apical and basolateral membranes of Caco-2 cells but also that the basolateral dipeptide transporter is distinct from the apical H(+)-dipeptide cotransporter. ..
  51. Iwasaki T, Murata Hori M, Ishitobi S, Hosoya H. Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells. Cell Struct Funct. 2001;26:677-83 pubmed
    ..Taken together, our data suggest that diphosphorylation of MRLC plays an important role in regulating actin filament assembly and reorganization in nonmuscle cells. ..
  52. Ohkoshi M, Okuda S. Growth inhibition of mouse autochthonous skin cancer by oral administration of new serine protease inhibitor ONO-3403. Anticancer Res. 2002;22:821-3 pubmed
    ..001) and prolonged survival-time (p<0.01). These results indicated that oral administration of the potent serine protease inhibitor ONO-3403 has an antitumor effect on malignant tumors. ..
  53. Asai A, Terasaki M, Nagao A. An epoxide-furanoid rearrangement of spinach neoxanthin occurs in the gastrointestinal tract of mice and in vitro: formation and cytostatic activity of neochrome stereoisomers. J Nutr. 2004;134:2237-43 pubmed
  54. Kannan Y, Moriyama M, Sugano T, Yamate J, Kuwamura M, Kagaya A, et al. Neurotrophic action of interleukin 3 and granulocyte-macrophage colony-stimulating factor on murine sympathetic neurons. Neuroimmunomodulation. 2000;8:132-41 pubmed
    ..Thus, IL-3 and GM-CSF appear to be able to stimulate sympathetic nerve growth, via specific cytokine receptors on neurons, which lead to activation of the MAP kinase pathway that then mediates the observed neurotrophic effects. ..
  55. Hidaka H, Ishiko T, Furuhashi T, Kamohara H, Suzuki S, Miyazaki M, et al. Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation. Cancer. 2002;95:1206-14 pubmed
    ..From this point of view, curcumin is a potent anticancer agent that inhibits the production of proinflammatory cytokines, including IL-8, by tumor cells. ..
  56. Iwakiri K, Ghazizadeh M, Jin E, Fujiwara M, Takemura T, Takezaki S, et al. Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris. J Invest Dermatol. 2004;122:937-44 pubmed
    ..Inhibition of PAR-2 resulted in a decreased HAT-induced IL-8 release. Thus, HAT might promote PAR-2-mediated IL-8 production to accumulate inflammatory cells in the epidermal layer of psoriasis. ..
  57. Yasui Y, Suzuki R, Kohno H, Miyamoto S, Beppu F, Hosokawa M, et al. 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats. Nutr Cancer. 2007;59:82-91 pubmed
    ..Our findings thus provide some novel insight into the chemopreventive effect of 9t,11t-CLA against preinitiation as well as postinitiation stages of colorectal carcinogenesis. ..
  58. Ohyama T, Imaizumi R, Igarashi K, Kobayashi H. Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH. J Bacteriol. 1992;174:7743-9 pubmed
  59. Nishimura H, Kawasaki Y, Nosaka K, Kaneko Y, Iwashima A. A constitutive thiamine metabolism mutation, thi80, causing reduced thiamine pyrophosphokinase activity in Saccharomyces cerevisiae. J Bacteriol. 1991;173:2716-9 pubmed
    ..These results suggest that the utilization and synthesis of thiamine in Saccharomyces cerevisiae is controlled negatively by the intracellular thiamine pyrophosphate level. ..
  60. Ueno K, Saha A, Kitagawa H, Satoh T. Effects of heptaminol AMP amidate (HAA) on cyclic AMP level and mitogen-induced proliferation of murine spleen cells. Jpn J Pharmacol. 1990;52:483-8 pubmed
    ..The present results supported the previous findings that HAA-mediated immunopotentiation was closely related with a cAMP level elevating property of HAA, and the compound also enhanced the function of helper T cells...
  61. Hiraga S, Niki H, Ogura T, Ichinose C, Mori H, Ezaki B, et al. Chromosome partitioning in Escherichia coli: novel mutants producing anucleate cells. J Bacteriol. 1989;171:1496-505 pubmed
    ..Cloning of the mukA gene indicates that the mukA1 mutation is recessive and that the mukA gene is identical to the tolC gene coding for an outer membrane protein. ..
  62. Matsui Y, Matsui R, Akada R, Toh e A. Yeast src homology region 3 domain-binding proteins involved in bud formation. J Cell Biol. 1996;133:865-78 pubmed
    ..Overproduction of either Rho3p or the Rho3p-related GTPase Rho4p suppressed the boi defect. These results demonstrate that Rho3p GTPases and Boi proteins function in the maintenance of cell polarity for bud formation. ..
  63. Kyaw Y, Hasegawa G, Takatsuka H, Shimada Hiratsuka M, Umezu H, Arakawa M, et al. Expression of macrophage colony-stimulating factor, scavenger receptors, and macrophage proliferation in the pregnant mouse uterus. Arch Histol Cytol. 1998;61:383-93 pubmed
  64. Yoshinaga Y, Kagawa T, Shimizu T, Inoue T, Takada S, Kuratsu J, et al. Wnt3a promotes hippocampal neurogenesis by shortening cell cycle duration of neural progenitor cells. Cell Mol Neurobiol. 2010;30:1049-58 pubmed publisher
  65. Komano T, Utsumi R, Kawamukai M. Functional analysis of the fic gene involved in regulation of cell division. Res Microbiol. 1991;142:269-77 pubmed
    ..Furthermore, it is also shown that cell division could be controlled by coordination of cAMP, Fic and Fts proteins. ..
  66. Akaogi K, Okabe Y, Funahashi K, Yoshitake Y, Nishikawa K, Yasumitsu H, et al. Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells. Biochem Biophys Res Commun. 1994;198:1046-53 pubmed
    ..These results suggest that the 30-kDa protein, tentatively named "tumor-derived adhesion factor (TAF)", may be related with the aberrant cell adhesion of cancer cells. ..
  67. Tanaka T, Sugiura H, Inaba R, Nishikawa A, Murakami A, Koshimizu K, et al. Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice. Carcinogenesis. 1999;20:1471-6 pubmed
    ..These findings might suggest that oral administration of citrus auraptene effectively enhanced macrophage and lymphocyte functions in mice. ..
  68. Taguchi K, Saitoh M, Arai Y, Momose K, Ogawa Y, Yasuda S, et al. Disparate effects of interleukin 11 and thrombopoietin on megakaryocytopoiesis in vitro. Cytokine. 2001;15:241-9 pubmed
    ..Our findings thus demonstrate that IL-11 principally stimulates megakaryocyte maturation rather than the proliferation of megakaryocytes, whereas TPO stimulates both. ..
  69. Taniura H, Kobayashi M, Yoshikawa K. Functional domains of necdin for protein-protein interaction, nuclear matrix targeting, and cell growth suppression. J Cell Biochem. 2005;94:804-15 pubmed
    ..In contrast, a necdin mutant lacking amino acids 191-222 did not induce such changes. These findings suggest that different functions of necdin are mediated via its distinct domains...
  70. Begum S, Nakaba S, Yamagishi Y, Yamane K, Islam M, Oribe Y, et al. A rapid decrease in temperature induces latewood formation in artificially reactivated cambium of conifer stems. Ann Bot. 2012;110:875-85 pubmed publisher
  71. Usami J, Hiromatsu K, Matsumoto Y, Maeda K, Inagaki H, Suzuki T, et al. A protective role of gamma delta T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice. Immunology. 1995;86:199-205 pubmed
    ..monocytogenes to grow exaggeratedly in the NOD mice. These results imply that gamma delta T cells may be mainly involved in protection against primary infection with L. monocytogenes in NOD mice. ..
  72. Kaneko Y, Tsukamoto A, Kurokawa K. Involvement of down-regulation-resistant protein kinase C in teleocidin inhibition of cell proliferation and calcium mobilization induced by epidermal growth factor and vasopressin in human hepatoma cells. Cancer Lett. 1993;71:103-8 pubmed
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