Genomes and Genes
Experts and Doctors on cell division in Japan
Topic: cell division
Publications214 found, 100 shown here
- Satomi H, Wang B, Fujisawa H, Otsuka F. Interferon-beta from melanoma cells suppresses the proliferations of melanoma cells in an autocrine manner. Cytokine. 2002;18:108-15 pubmed..Furthermore, melanoma cells are capable of suppressing their own proliferation via secretion of endogenous IFN-beta. This finding may have important implications for melanoma therapy. ..
- Nagai H, Yabe A, Mine N, Mikami I, Fujiwara H, Terada Y, et al. Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growth. Cancer Lett. 2003;193:41-7 pubmed..Transfection of a DRHC expression vector inhibited growth of cancer cells in liquid medium or soft agar. The results suggest that loss of expression of DRHC may play a role in human carcinogenesis. ..
- Takahashi T, Kamimura A, Hamazono Matsuoka T, Honda S. Phosphatidic acid has a potential to promote hair growth in vitro and in vivo, and activates mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in hair epithelial cells. J Invest Dermatol. 2003;121:448-56 pubmed
- Maemondo M, Saijo Y, Narumi K, Kikuchi T, Usui K, Tazawa R, et al. Gene therapy with secretory leukoprotease inhibitor promoter-controlled replication-competent adenovirus for non-small cell lung cancer. Cancer Res. 2004;64:4611-20 pubmed..These results suggest that AdSLPI.E1AdB could provide a selective therapeutic modality for NSCLC and that the combination of AdSLPI.E1AdB and AdCMV.NK4 may be a more effective gene therapy for NSCLC. ..
- Fujii C, Nakamoto Y, Lu P, Tsuneyama K, Popivanova B, Kaneko S, et al. Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. Int J Cancer. 2005;114:209-18 pubmed..These observations suggest that aberrantly expressed Pim-3 can cause autonomous cell proliferation or prevent apoptosis in hepatoma cell lines. ..
- Sakaguchi Y, Sekiya I, Yagishita K, Muneta T. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum. 2005;52:2521-9 pubmed..Superiority of synovium as a potential source of MSCs for clinical applications was demonstrated. ..
- Sumita T, Yoko o T, Shimma Y, Jigami Y. Comparison of cell wall localization among Pir family proteins and functional dissection of the region required for cell wall binding and bud scar recruitment of Pir1p. Eukaryot Cell. 2005;4:1872-81 pubmed..This is the first report that bud scars contain proteins like Pir1p as internal components. ..
- Ishikawa S, Kawai Y, Hiramatsu K, Kuwano M, Ogasawara N. A new FtsZ-interacting protein, YlmF, complements the activity of FtsA during progression of cell division in Bacillus subtilis. Mol Microbiol. 2006;60:1364-80 pubmed..These results suggest that YlmF has an overlapping function with FtsA in stimulating the formation of Z rings in B. subtilis. ..
- Imokawa G, Yada Y, Miyagishi M. Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes. J Biol Chem. 1992;267:24675-80 pubmed..These studies suggest that ETs produced and secreted by keratinocytes play an essential role in the maintenance of melanocyte proliferation and UV hyperpigmentation in the epidermis. ..
- Senga T, Iwamoto T, Humphrey S, Yokota T, Taparowsky E, Hamaguchi M. Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells. Oncogene. 2002;21:8186-91 pubmed..These results indicate that Stat3 mediates cellular growth by modulating AP-1 activity through the induction of BATF. ..
- Amemiya K, Kaneko Y, Muramatsu T, Shimono M, Inoue T. Pulp cell responses during hypoxia and reoxygenation in vitro. Eur J Oral Sci. 2003;111:332-8 pubmed..These results suggest that dynamic responses to hypoxia and reoxygenation occur in pulp cells. ..
- Ohsugi T, Horie R, Kumasaka T, Ishida A, Ishida T, Yamaguchi K, et al. In vivo antitumor activity of the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin in a mouse model of adult T-cell leukemia. Carcinogenesis. 2005;26:1382-8 pubmed..These results suggest that DHMEQ induces apoptosis in HTLV-I-transformed cells in vivo, resulting in inhibition of tumor formation and organ infiltration, thereby enhancing survival. ..
- Morikawa K, Oseko F, Morikawa S. The role of CD45 in the activation, proliferation and differentiation of human B lymphocytes. Int J Hematol. 1991;54:495-504 pubmed..These results indicated that CD45 antigen defined by T29/33 is involved in the activation, proliferation, and differentiation signals of human B lymphocytes. ..
- Hoshino S, Miyazawa H, Enomoto T, Hanaoka F, Kikuchi Y, Kikuchi A, et al. A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells. EMBO J. 1989;8:3807-14 pubmed..A possible role of GST1-Hs in mammalian cell growth is discussed. ..
- Terakawa N, Ikegami H, Shimizu I, Inoue M, Tanizawa O, Matsumoto K. Inhibitory effects of danazol and medroxyprogesterone acetate on [3H]thymidine incorporation in human endometrial cancer cells. J Steroid Biochem. 1988;31:131-5 pubmed
- Suzuki T, Sadakata Y, Kashiwagi K, Hoshino K, Kakinuma Y, Shirahata A, et al. Overproduction of S-adenosylmethionine decarboxylase in ethylglyoxal-bis(guanylhydrazone)-resistant mouse FM3A cells. Eur J Biochem. 1993;215:247-53 pubmed..The variant cell line is convenient for studying the regulation of AdoMetDC and the physiological function of polyamines. ..
- Ueguchi C, Kakeda M, Mizuno T. Autoregulatory expression of the Escherichia coli hns gene encoding a nucleoid protein: H-NS functions as a repressor of its own transcription. Mol Gen Genet. 1993;236:171-8 pubmed..These results support the view that the nucleoid protein, H-NS, can function as a transcriptional regulator. ..
- Akagi M, Yasui W, Akama Y, Yokozaki H, Tahara H, Haruma K, et al. Inhibition of cell growth by transforming growth factor beta 1 is associated with p53-independent induction of p21 in gastric carcinoma cells. Jpn J Cancer Res. 1996;87:377-84 pubmed..These results suggest that the growth inhibition of tumor cells by TGFbeta 1 is associated with p53-independent induction of p21, subsequent suppression of cdk activity and a decrease in cyclin A protein in TMK-1 cells. ..
- Nishizumi H, Yamamoto T. Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells. J Immunol. 1997;158:2350-5 pubmed..Our data suggest that the activity of the other Src family kinases, such as c-Src, can complement the role of Lyn in inducing most, but not all, biologic and biochemical responses to Fc epsilon RI cross-linking. ..
- Kobayashi M, Asai Y, Hatakeyama K, Kijima N, Wachi M, Nagai K, et al. Cloning, sequencing, and characterization of the ftsZ gene from coryneform bacteria. Biochem Biophys Res Commun. 1997;236:383-8 pubmed publisher..Expression of Br. flavum ftsZ gene in E. coli, JM109 inhibited its cell division, leading to filamentation. This suggested that the Br. flavum ftsZ product competed with the E. coli ftsZ product...
- Madaule P, Eda M, Watanabe N, Fujisawa K, Matsuoka T, Bito H, et al. Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature. 1998;394:491-4 pubmed..We propose that citron kinase regulates cytokinesis at a step after Rho in the contractile process. ..
- Fujimoto K, Hosotani R, Doi R, Wada M, Lee J, Koshiba T, et al. Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells. Int J Cancer. 1999;81:637-44 pubmed..TAC-101 may therefore be a useful agent for new therapeutic strategies focusing on inhibition of pancreatic-cancer-cell proliferation. ..
- Li Z, Shiota K. Stage-specific homeotic vertebral transformations in mouse fetuses induced by maternal hyperthermia during somitogenesis. Dev Dyn. 1999;216:336-48 pubmed
- Emoto M, Ishiguro M, Iwasaki H, Kikuchi M, Kawarabayashi T. TNP-470 inhibits growth and the production of vascular endothelial growth factor of uterine carcinosarcoma cells in vitro. Anticancer Res. 2000;20:601-4 pubmed..However, further in vivo experimental studies using TNP-470 for this tumor will be necessary before any definitive conclusions can be made. ..
- Nomura K, Nakamura H, Suzuki N. False fertilization in sea urchin eggs induced by diabolin, a 120K kelp protein. Biochem Biophys Res Commun. 2000;272:691-3 pubmed..A question was left to be solved as to how the kelp on the southeast coast of Hokkaido Island could develop the defense mechanism against the sea urchin on Honshu Island separated by Tsugaru Straits. ..
- Hirota A, Taki S, Kawaii S, Yano M, Abe N. 1,1-Diphenyl-2-picrylhydrazyl radical-scavenging compounds from soybean miso and antiproliferative activity of isoflavones from soybean miso toward the cancer cell lines. Biosci Biotechnol Biochem. 2000;64:1038-40 pubmed..The antiproliferative activity of four of the isolated isoflavones toward three cancer cell lines was examined. 8-Hydroxygenistein showed the highest activity (IC50=5.2 microM) toward human promyelocytic leukemia cells (HL-60). ..
- Yamada K, Mizutani T, Shou Z, Yazawa T, Sekiguchi T, Yoshino M, et al. Cloning and functional expression of an E box-binding protein from rat granulosa cells. Biol Reprod. 2001;64:1315-9 pubmed..Thus, we report molecular cloning, expression, and functional characterization of full-length rat USF2 cDNA. ..
- Maeda Y, Shiratsuchi A, Namiki M, Nakanishi Y. Inhibition of sperm production in mice by annexin V microinjected into seminiferous tubules: possible etiology of phagocytic clearance of apoptotic spermatogenic cells and male infertility. Cell Death Differ. 2002;9:742-9 pubmed..This suggests that the elimination of apoptotic spermatogenic cells is required for the production of sperm...
- Miyoshi K, Shirai C, Mizuta K. Transcription of genes encoding trans-acting factors required for rRNA maturation/ribosomal subunit assembly is coordinately regulated with ribosomal protein genes and involves Rap1 in Saccharomyces cerevisiae. Nucleic Acids Res. 2003;31:1969-73 pubmed
- Kominami R, Yasutaka S, Taniguchi Y, Shinohara H. Proliferating cells in the rat anterior pituitary during the postnatal period: immunoelectron microscopic observations using monoclonal anti-bromodeoxyuridine antibody. Histochem Cell Biol. 2003;120:223-33 pubmed..These results suggest: (1) the majority of proliferating cells were mature cells producing anterior pituitary hormone(s) and (2) most of the agranular proliferating cells maybe FS cells. The possibility of the latter is discussed. ..
- Nakamura K, Nonaka H, Saito H, Tanaka M, Miyajima A. Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice. Hepatology. 2004;39:635-44 pubmed..In conclusion, OSM and its signaling pathway may provide a useful therapeutic target for liver regeneration. ..
- Yudoh K, Nguyen v, Nakamura H, Hongo Masuko K, Kato T, Nishioka K. Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function. Arthritis Res Ther. 2005;7:R380-91 pubmed..New efforts to prevent the development and progression of OA may include strategies and interventions aimed at reducing oxidative damage in articular cartilage. ..
- Funaba M, Nakaya K, Ikeda T, Murakami M, Tsuchida K, Sugino H. Requirement of Smad3 for mast cell growth. Cell Immunol. 2006;240:47-52 pubmed
- Iida H, Ota S, Inouye I. Cleavage, incomplete inversion, and cytoplasmic bridges in Gonium pectorale (Volvocales, Chlorophyta). J Plant Res. 2013;126:699-707 pubmed publisher..Cytoplasmic bridges and cortical microtubules in G. pectorale suggest that a mechanism of kinesin-microtubule machinery similar to that in other volvocine algae is responsible for inversion in this species. ..
- Asano M, Furukawa K, Kido M, Matsumoto S, Umesaki Y, Kochibe N, et al. Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells. EMBO J. 1997;16:1850-7 pubmed..These observations suggest that GalT plays critical roles in the regulation of proliferation and differentiation of epithelial cells after birth, although this enzyme is dispensable during embryonic development. ..
- Nishikori T, Ochi M, Uchio Y, Maniwa S, Kataoka H, Kawasaki K, et al. Effects of low-intensity pulsed ultrasound on proliferation and chondroitin sulfate synthesis of cultured chondrocytes embedded in Atelocollagen gel. J Biomed Mater Res. 2002;59:201-6 pubmed..In this three-dimensional culture model, these results suggest that US exposure may be clinically useful in improving the quality of chondrocyte-Atelocollagen implants for transplantation into articular cartilage defects. ..
- Matsumoto K, Ishikawa H, Nishimura D, Hamasaki K, Nakao K, Eguchi K. Antiangiogenic property of pigment epithelium-derived factor in hepatocellular carcinoma. Hepatology. 2004;40:252-9 pubmed..Reduction of serum PEDF concentration associated with the development of chronic liver diseases may contribute to the progression of HCC. In addition, gene therapy using PEDF may provide an efficient treatment for HCC. ..
- Yamane A, Seetharam L, Yamaguchi S, Gotoh N, Takahashi T, Neufeld G, et al. A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1). Oncogene. 1994;9:2683-90 pubmed..Therefore two reciprocal communication systems, VEGF-Flt receptor family and HGF-Met receptor, may exist in hepatic tissue. ..
- Moon B, Yoshida T, Shiiba M, Nakao K, Katsuki M, Takaki S, et al. Functional dissection of the cytoplasmic subregions of the interleukin-5 receptor alpha chain in growth and immunoglobulin G1 switch recombination of B cells. Immunology. 2001;102:289-300 pubmed..Thus, this present approach offers new insights into the functions of the cytoplasmic subregions of IL-5Ralpha, in particular its carboxy-terminal region. ..
- Koga H, Matsui S, Hirota T, Takebayashi S, Okumura K, Saya H. A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes. Oncogene. 1999;18:3799-809 pubmed..These observations suggest that h-l(3)mbt protein has functions distinct from those of PcG proteins and may play a role in proper progression of cell division. ..
- Shinagawa T, Nomura T, Colmenares C, Ohira M, Nakagawara A, Ishii S. Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice. Oncogene. 2001;20:8100-8 pubmed..Human c-ski gene was mapped to a region close to the p73 tumor suppressor gene at the 1p36.3 locus, which is already known to contain multiple uncharacterized tumor suppressor genes. ..
- Seki N, Hashimoto N, Sano H, Horiuchi S, Yagui K, Makino H, et al. Mechanisms involved in the stimulatory effect of advanced glycation end products on growth of rat aortic smooth muscle cells. Metabolism. 2003;52:1558-63 pubmed..As pathways involving AGE-galectin-3 interaction thus may be involved in macroangiopathy, AGE appears to be important to the role of SMC in accelerated atherosclerosis associated with diabetes mellitus. ..
- Yao Z, Nakamura H, Masuko Hongo K, Suzuki Kurokawa M, Nishioka K, Kato T. Characterisation of cartilage intermediate layer protein (CILP)-induced arthropathy in mice. Ann Rheum Dis. 2004;63:252-8 pubmed..An immune response to putative murine CILP/NTPPH may be involved in the ectopic calcifications in the arthritic mice. ..
- Shima Y, Kengaku M, Hirano T, Takeichi M, Uemura T. Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin. Dev Cell. 2004;7:205-16 pubmed..Based on these findings, we discuss how Celsr2 may regulate dendritic maintenance and growth. ..
- Kawakami K, Ito K, Nakamura Y. Differential regulation of two genes encoding lysyl-tRNA synthetases in Escherichia coli: lysU-constitutive mutations compensate for a lysS null mutation. Mol Microbiol. 1992;6:1739-45 pubmed..Furthermore, deletion mutations created immediately upstream of the lysU promoter restored growth of lysS1. These results suggest that transcription of lysU is negatively controlled by a cis-element located upstream of the promoter. ..
- Jia G, Tohyama C, Sone H. DNA damage triggers imbalance of proliferation and apoptosis during development of preneoplastic foci in the liver of Long-Evans Cinnamon rats. Int J Oncol. 2002;21:755-61 pubmed..These findings suggest that DNA damage, reflected in DNA strand breaks, plays a critical role in the development of hepatocellular preneoplastic foci, with an imbalance between high proliferation and relatively low apoptosis. ..
- Sasagawa K, Matsudo Y, Kang M, Fujimura L, Iitsuka Y, Okada S, et al. Identification of Nd1, a novel murine kelch family protein, involved in stabilization of actin filaments. J Biol Chem. 2002;277:44140-6 pubmed..These data suggest that Nd1-L functions as a stabilizer of actin filaments as an actin-binding protein and may play a role in the dynamic organization of the actin cytoskeleton. ..
- Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, et al. Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev. 2003;17:2436-49 pubmed..Our findings provide a new pathogenetic model of RA and suggest that Synoviolin/Hrd1 could be targeted as a therapeutic strategy for RA...
- Otake K, Omoto S, Yamamoto T, Okuyama H, Okada H, Okada N, et al. HIV-1 Nef protein in the nucleus influences adipogenesis as well as viral transcription through the peroxisome proliferator-activated receptors. AIDS. 2004;18:189-98 pubmed..Nef may be involved in both viral replication and the wasting syndrome associated with AIDS. ..
- Saito H, Inui K. Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2. Am J Physiol. 1993;265:G289-94 pubmed..These findings suggest not only that dipeptide transporters exist on both the apical and basolateral membranes of Caco-2 cells but also that the basolateral dipeptide transporter is distinct from the apical H(+)-dipeptide cotransporter. ..
- Iwasaki T, Murata Hori M, Ishitobi S, Hosoya H. Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells. Cell Struct Funct. 2001;26:677-83 pubmed..Taken together, our data suggest that diphosphorylation of MRLC plays an important role in regulating actin filament assembly and reorganization in nonmuscle cells. ..
- Ohkoshi M, Okuda S. Growth inhibition of mouse autochthonous skin cancer by oral administration of new serine protease inhibitor ONO-3403. Anticancer Res. 2002;22:821-3 pubmed..001) and prolonged survival-time (p<0.01). These results indicated that oral administration of the potent serine protease inhibitor ONO-3403 has an antitumor effect on malignant tumors. ..
- Asai A, Terasaki M, Nagao A. An epoxide-furanoid rearrangement of spinach neoxanthin occurs in the gastrointestinal tract of mice and in vitro: formation and cytostatic activity of neochrome stereoisomers. J Nutr. 2004;134:2237-43 pubmed
- Kannan Y, Moriyama M, Sugano T, Yamate J, Kuwamura M, Kagaya A, et al. Neurotrophic action of interleukin 3 and granulocyte-macrophage colony-stimulating factor on murine sympathetic neurons. Neuroimmunomodulation. 2000;8:132-41 pubmed..Thus, IL-3 and GM-CSF appear to be able to stimulate sympathetic nerve growth, via specific cytokine receptors on neurons, which lead to activation of the MAP kinase pathway that then mediates the observed neurotrophic effects. ..
- Hidaka H, Ishiko T, Furuhashi T, Kamohara H, Suzuki S, Miyazaki M, et al. Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation. Cancer. 2002;95:1206-14 pubmed..From this point of view, curcumin is a potent anticancer agent that inhibits the production of proinflammatory cytokines, including IL-8, by tumor cells. ..
- Iwakiri K, Ghazizadeh M, Jin E, Fujiwara M, Takemura T, Takezaki S, et al. Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris. J Invest Dermatol. 2004;122:937-44 pubmed..Inhibition of PAR-2 resulted in a decreased HAT-induced IL-8 release. Thus, HAT might promote PAR-2-mediated IL-8 production to accumulate inflammatory cells in the epidermal layer of psoriasis. ..
- Yasui Y, Suzuki R, Kohno H, Miyamoto S, Beppu F, Hosokawa M, et al. 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats. Nutr Cancer. 2007;59:82-91 pubmed..Our findings thus provide some novel insight into the chemopreventive effect of 9t,11t-CLA against preinitiation as well as postinitiation stages of colorectal carcinogenesis. ..
- Ohyama T, Imaizumi R, Igarashi K, Kobayashi H. Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH. J Bacteriol. 1992;174:7743-9 pubmed
- Nishimura H, Kawasaki Y, Nosaka K, Kaneko Y, Iwashima A. A constitutive thiamine metabolism mutation, thi80, causing reduced thiamine pyrophosphokinase activity in Saccharomyces cerevisiae. J Bacteriol. 1991;173:2716-9 pubmed..These results suggest that the utilization and synthesis of thiamine in Saccharomyces cerevisiae is controlled negatively by the intracellular thiamine pyrophosphate level. ..
- Ueno K, Saha A, Kitagawa H, Satoh T. Effects of heptaminol AMP amidate (HAA) on cyclic AMP level and mitogen-induced proliferation of murine spleen cells. Jpn J Pharmacol. 1990;52:483-8 pubmed..The present results supported the previous findings that HAA-mediated immunopotentiation was closely related with a cAMP level elevating property of HAA, and the compound also enhanced the function of helper T cells...
- Hiraga S, Niki H, Ogura T, Ichinose C, Mori H, Ezaki B, et al. Chromosome partitioning in Escherichia coli: novel mutants producing anucleate cells. J Bacteriol. 1989;171:1496-505 pubmed..Cloning of the mukA gene indicates that the mukA1 mutation is recessive and that the mukA gene is identical to the tolC gene coding for an outer membrane protein. ..
- Matsui Y, Matsui R, Akada R, Toh e A. Yeast src homology region 3 domain-binding proteins involved in bud formation. J Cell Biol. 1996;133:865-78 pubmed..Overproduction of either Rho3p or the Rho3p-related GTPase Rho4p suppressed the boi defect. These results demonstrate that Rho3p GTPases and Boi proteins function in the maintenance of cell polarity for bud formation. ..
- Kyaw Y, Hasegawa G, Takatsuka H, Shimada Hiratsuka M, Umezu H, Arakawa M, et al. Expression of macrophage colony-stimulating factor, scavenger receptors, and macrophage proliferation in the pregnant mouse uterus. Arch Histol Cytol. 1998;61:383-93 pubmed
- Komano T, Utsumi R, Kawamukai M. Functional analysis of the fic gene involved in regulation of cell division. Res Microbiol. 1991;142:269-77 pubmed..Furthermore, it is also shown that cell division could be controlled by coordination of cAMP, Fic and Fts proteins. ..
- Akaogi K, Okabe Y, Funahashi K, Yoshitake Y, Nishikawa K, Yasumitsu H, et al. Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells. Biochem Biophys Res Commun. 1994;198:1046-53 pubmed..These results suggest that the 30-kDa protein, tentatively named "tumor-derived adhesion factor (TAF)", may be related with the aberrant cell adhesion of cancer cells. ..
- Tanaka T, Sugiura H, Inaba R, Nishikawa A, Murakami A, Koshimizu K, et al. Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice. Carcinogenesis. 1999;20:1471-6 pubmed..These findings might suggest that oral administration of citrus auraptene effectively enhanced macrophage and lymphocyte functions in mice. ..
- Taguchi K, Saitoh M, Arai Y, Momose K, Ogawa Y, Yasuda S, et al. Disparate effects of interleukin 11 and thrombopoietin on megakaryocytopoiesis in vitro. Cytokine. 2001;15:241-9 pubmed..Our findings thus demonstrate that IL-11 principally stimulates megakaryocyte maturation rather than the proliferation of megakaryocytes, whereas TPO stimulates both. ..
- Taniura H, Kobayashi M, Yoshikawa K. Functional domains of necdin for protein-protein interaction, nuclear matrix targeting, and cell growth suppression. J Cell Biochem. 2005;94:804-15 pubmed..In contrast, a necdin mutant lacking amino acids 191-222 did not induce such changes. These findings suggest that different functions of necdin are mediated via its distinct domains...
- Usami J, Hiromatsu K, Matsumoto Y, Maeda K, Inagaki H, Suzuki T, et al. A protective role of gamma delta T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice. Immunology. 1995;86:199-205 pubmed..monocytogenes to grow exaggeratedly in the NOD mice. These results imply that gamma delta T cells may be mainly involved in protection against primary infection with L. monocytogenes in NOD mice. ..
- Kaneko Y, Tsukamoto A, Kurokawa K. Involvement of down-regulation-resistant protein kinase C in teleocidin inhibition of cell proliferation and calcium mobilization induced by epidermal growth factor and vasopressin in human hepatoma cells. Cancer Lett. 1993;71:103-8 pubmed..This down-regulation-resistant PKC is suggested to be responsible for the inhibitory effect of teleocidin on cell proliferation and calcium mobilization induced by epidermal growth factor and vasopressin. ..
- Kishi A, Chiba T, Sugiyama M, Machide M, Nagata Y, Amanuma H, et al. Erythropoietin receptor binds to Friend virus gp55 through other membrane components. Biochem Biophys Res Commun. 1993;192:1131-8 pubmed
- Matsubayashi Y, Takagi L, Sakagami Y. Phytosulfokine-alpha, a sulfated pentapeptide, stimulates the proliferation of rice cells by means of specific high- and low-affinity binding sites. Proc Natl Acad Sci U S A. 1997;94:13357-62 pubmed..These results suggest that a signal transduction pathway mediated by peptide factors is involved in plant cell proliferation. ..
- Komatsu Y, Shibuya H, Takeda N, Ninomiya Tsuji J, Yasui T, Miyado K, et al. Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev. 2002;119:239-49 pubmed..These results indicate a possibility that TAB1 plays an important role in mammalian embryogenesis and is required for TAK1 activation in TGF-beta signaling. ..
- Khan M, Nomura T, Chiba T, Tanaka K, Yoshida H, Mori K, et al. The fusion oncoprotein PML-RARalpha induces endoplasmic reticulum (ER)-associated degradation of N-CoR and ER stress. J Biol Chem. 2004;279:11814-24 pubmed..Overexpression of N-CoR induces the differentiation of APL-derived NB4 cells, suggesting that the low levels of N-CoR in the nucleus may contribute at least partly to PML-RARalpha-mediated leukemogenesis. ..
- Sekine Suzuki E, Yu D, Kubota N, Okayasu R, Anzai K. Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells. Biochem Biophys Res Commun. 2008;377:341-345 pubmed publisher..G2/M arrest by SFN, a typical response for cells exposed to ionizing radiation was also observed. Our new data indicate the clear induction of DSBs by SFN and a useful anti-tumor aspect of SFN through the induction of DNA DSBs. ..
- Miyazaki M, Wahid S, Sato J. In vivo and in vitro test for growth potential of liver cells from rats during early stage of hepatocarcinogenesis by 3'-methyl-4-dimethylaminoazobenzene. J Cancer Res Clin Oncol. 1989;115:1-8 pubmed..As described above, liver cells from rats fed 3'-Me-DAB demonstrated much greater proliferative ability than normal control cells in vivo and in vitro...
- Haraguchi R, Mo R, Hui C, Motoyama J, Makino S, Shiroishi T, et al. Unique functions of Sonic hedgehog signaling during external genitalia development. Development. 2001;128:4241-50 pubmed..These results suggest a dual mode of Shh function, first by the regulation of initiating GT outgrowth, and second, by subsequent GT differentiation. ..
- Asai T, Nagatsuka M, Kuromi K, Yamakawa S, Kurohane K, Ogino K, et al. Suppression of tumor growth by novel peptides homing to tumor-derived new blood vessels. FEBS Lett. 2002;510:206-10 pubmed..Taken together, ASSSYPLIHWRPWAR-peptide may cause tumor dormancy through inhibition of angiogenesis, and the WRP sequence may be the minimal and essential sequence for this activity. ..
- Hamaguchi Y, Kuriyama R. Effects of the phosphatase inhibitors, okadaic acid, ATPgammaS, and calyculin A on the dividing sand dollar egg. Cell Struct Funct. 2002;27:127-37 pubmed..Consequently, the phosphatase inhibitors inhibited the transition from mitosis to interphase by mediating cortical accumulation of actin filaments and/or fragmentation of microtubules. ..
- Kubota N, Ohta E, Ohta S, Koizumi F, Suzuki M, Ichimura M, et al. Piericidins C5 and C6: new 4-pyridinol compounds produced by Streptomyces sp. and Nocardioides sp. Bioorg Med Chem. 2003;11:4569-75 pubmed..The structures were determined on the basis of their spectroscopic data. Both new compounds inhibited cell division of fertilized starfish (Asterina pectinifera) eggs at the minimum inhibitory concentration of 0.09 microg/mL...
- Machida H, Nakajima S, Shikano N, Nishio J, Okada S, Asayama M, et al. Heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis. Cancer Sci. 2005;96:911-7 pubmed..The findings suggest that 17AAG effectively sensitizes radioresistant cells to radiation by inhibiting the PI3K-Akt pathway. Targeting the PI3K-Akt pathway with 17AAG could be a useful strategy for radiosensitization of carcinomas. ..
- Ichinose T, Takano H, Miyabara Y, Sagai M. Long-term exposure to diesel exhaust enhances antigen-induced eosinophilic inflammation and epithelial damage in the murine airway. Toxicol Sci. 1998;44:70-9 pubmed..We conclude that the combination of antigen and chronic exposure to DE produces increased eosinophilic inflammation, and cell damage to the epithelium may depend on the degree of eosinophilic inflammation in the airway. ..
- Nakano H, Yamada Y, Ishikura H, Inokuchi H. A mutation in the gene for trigger factor suppresses the defect in cell division in the divE42 mutant of Escherichia coli K12. Mol Gen Genet. 1998;260:75-80 pubmed..A model is proposed that accounts for the phenotypes of the divE42 mutant and the TR4 suppressor mutant. ..
- Kono K, Takahashi J, Ueba T, Mori H, Hashimoto N, Fukumoto M. Effects of combination chemotherapy with biscoclaurine-derived alkaloid (Cepharanthine) and nimustine hydrochloride on malignant glioma cell lines. J Neurooncol. 2002;56:101-8 pubmed..In combination with ACNU, the effects of the higher concentrations of CEP were enhanced. ..
- Wadhwa R, Takano S, Taira K, Kaul S. Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells. J Gene Med. 2004;6:439-44 pubmed..The data demonstrate that suppression of mortalin is sufficient to induce growth arrest in human immortalized cells that have compromised p53 and pRB functions and possess telomerase activity. ..
- Nakano K, Arai R, Mabuchi I. The small GTP-binding protein Rho1 is a multifunctional protein that regulates actin localization, cell polarity, and septum formation in the fission yeast Schizosaccharomyces pombe. Genes Cells. 1997;2:679-94 pubmed..Moreover, we observed that Rho1 is localized to the cell periphery and to the septum. Rho1 is involved in actin patch localization, the control of cell polarity, the regulation of septation, and cell wall synthesis. ..
- Yasunari T, Yanagihara N, Komatsu T, Moriwaki M, Shiraki K, Miki T, et al. Effect of retinoic acid on proliferation and polyamine metabolism in cultured bovine retinal pigment epithelial cells. Ophthalmic Res. 1999;31:24-32 pubmed
- Asano T, Shoda J, Ueda T, Kawamoto T, Todoroki T, Shimonishi M, et al. Expressions of cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression. Clin Cancer Res. 2002;8:1157-67 pubmed..In epithelial-stromal interactions, the increased PGE(2) synthesis in the adjacent stroma and its biological effect via EP(4) on the carcinoma cells may contribute to tumor growth and progression of gallbladder carcinoma. ..
- Takahashi M, Fujita M, Furukawa Y, Hamamoto R, Shimokawa T, Miwa N, et al. Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. Cancer Res. 2002;62:5651-6 pubmed..These data suggest that APCDD1 is directly regulated by the beta-catenin/Tcf complex and that its elevated expression is likely to contribute to colorectal tumorigenesis. ..
- Harada J, Kokura K, Kanei Ishii C, Nomura T, Khan M, Kim Y, et al. Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. J Biol Chem. 2003;278:38998-9005 pubmed..The HIPK2 co-repressor activity may be regulated by an uncharacterized HIPK2 kinase. These results indicate that HIPK2, together with c-Ski, plays an important role in the negative regulation of BMP-induced transcriptional activation. ..