Experts and Doctors on cell differentiation in United States

Summary

Locale: United States
Topic: cell differentiation

Top Publications

  1. Brittis P, Silver J. Exogenous glycosaminoglycans induce complete inversion of retinal ganglion cell bodies and their axons within the retinal neuroepithelium. Proc Natl Acad Sci U S A. 1994;91:7539-42 pubmed
  2. Crandall D, Armellino D, Busler D, McHendry Rinde B, Kral J. Angiotensin II receptors in human preadipocytes: role in cell cycle regulation. Endocrinology. 1999;140:154-8 pubmed
    ..These findings indicate that AII has early, receptor-mediated effects on cell cycle progression in human preadipocytes that may contribute to differentiation to the adipocyte phenotype. ..
  3. Magdaleno S, Keshvara L, Curran T. Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice. Neuron. 2002;33:573-86 pubmed
    ..These results indicate that Reelin does not function simply as a positional signal. Rather, it appears to participate in multiple events critical for neuronal migration and cell positioning. ..
  4. Broome A, Ryan D, Eckert R. S100 protein subcellular localization during epidermal differentiation and psoriasis. J Histochem Cytochem. 2003;51:675-85 pubmed
    ..These studies also indicate, as reported previously, that S100A7, S100A8, and S100A9 expression is markedly altered in psoriasis, suggesting a role for these proteins in disease pathogenesis. ..
  5. Revilla i Domingo R, Davidson E. Developmental gene network analysis. Int J Dev Biol. 2003;47:695-703 pubmed
  6. Beer T, Myrthue A. Calcitriol in cancer treatment: from the lab to the clinic. Mol Cancer Ther. 2004;3:373-81 pubmed
    ..Further work is needed to elucidate the molecular mechanisms of antineoplastic activity and optimal clinical applications of calcitriol in cancer. ..
  7. Mhawech P. 14-3-3 proteins--an update. Cell Res. 2005;15:228-36 pubmed
    ..Gene silencing of 14-3-3sigma by CpG methylation has been found in many human cancer types. This suggests that therapy-targeting 14-3-3sigma may be beneficial for future cancer treatment. ..
  8. Plotnikov S, Millard A, Campagnola P, Mohler W. Characterization of the myosin-based source for second-harmonic generation from muscle sarcomeres. Biophys J. 2006;90:693-703 pubmed
    ..This study should guide the interpretation of SHG contrast in images of cardiac and skeletal muscle tissue for a variety of biomedical applications. ..
  9. Asirvatham A, Schmidt M, Chaudhary J. Non-redundant inhibitor of differentiation (Id) gene expression and function in human prostate epithelial cells. Prostate. 2006;66:921-35 pubmed
    ..A complex equilibrium between Id isoforms determines the cell fate. Id1 and Id3 target cellular proliferation, Id2 targets apoptosis, and Id4 may act as a potential tumor suppressor in prostate epithelial cells. ..

More Information

Publications696 found, 100 shown here

  1. Tang D, Cao L, Chou W, Shun L, Farag C, Atkinson M, et al. Role of Pax4 in Pdx1-VP16-mediated liver-to-endocrine pancreas transdifferentiation. Lab Invest. 2006;86:829-41 pubmed
    ..These studies indicate that activation of Pax4 in Pdx1-VP16-expressing cells reprograms pancreatic precursor-like WB-1 cells into glucose-responsive, more mature insulin-producing cells. ..
  2. Oh S, Witek R, Bae S, Zheng D, Jung Y, Piscaglia A, et al. Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration. Gastroenterology. 2007;132:1077-87 pubmed
    ..The present study analyzed whether the bone marrow cells are a source of hepatic oval cells involved in rat liver regeneration induced by 2-acetylaminofluorene (2-AAF) and 70% partial hepatectomy (PHx)...
  3. Galvin K, Travis E, Yee D, Magnuson T, Vivian J. Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells. J Biol Chem. 2010;285:19747-56 pubmed publisher
    ..We conclude that autocrine Nodal signaling in undifferentiated mouse ES cells modulates the vital pluripotency pathway of BMP signaling. ..
  4. Giltiay N, Lu Y, Allman D, Jørgensen T, Li X. The adaptor molecule Act1 regulates BAFF responsiveness and self-reactive B cell selection during transitional B cell maturation. J Immunol. 2010;185:99-109 pubmed publisher
    ..Taken together, our results suggest that the transitional stage is a critical point of action of Act1 in the elimination of autoreactive B cells and in the regulation of peripheral B cell homeostasis. ..
  5. Peng H, Guerau de Arellano M, Mehta V, Yang Y, Huss D, Papenfuss T, et al. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor ?B (NF-?B) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem. 2012;287:28017-26 pubmed publisher
    ..Taken together, these studies indicate that by suppression of both NF-?B and ERK1/2-MSK1 signaling, DMF inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation. ..
  6. Xu S, Hafer N, Agunwamba B, Schedl P. The CPEB protein Orb2 has multiple functions during spermatogenesis in Drosophila melanogaster. PLoS Genet. 2012;8:e1003079 pubmed publisher
    ..Additionally, analysis of a partial loss of function orb2 mutant suggests that the orb2 differentiation phenotypes are independent of the earlier arrest in meiosis. ..
  7. Emborg M, Liu Y, Xi J, Zhang X, Yin Y, Lu J, et al. Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain. Cell Rep. 2013;3:646-50 pubmed publisher
    ..This finding represents a significant step toward personalized regenerative therapies. ..
  8. Liu Y, Weick J, Liu H, Krencik R, Zhang X, Ma L, et al. Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nat Biotechnol. 2013;31:440-7 pubmed publisher
    ..Our findings support the prospect of using human stem cell-derived MGE-like progenitors in developing therapies for neurological disorders of learning and memory. ..
  9. Rusconi J, Corbin V. Evidence for a novel Notch pathway required for muscle precursor selection in Drosophila. Mech Dev. 1998;79:39-50 pubmed
  10. Mori M, Jefferson J, Hummel M, Garbe D. CNTF: a putative link between dopamine D2 receptors and neurogenesis. J Neurosci. 2008;28:5867-9 pubmed publisher
  11. Tigno Aranjuez J, Jaini R, Tuohy V, Lehmann P, Tary Lehmann M. Encephalitogenicity of complete Freund's adjuvant relative to CpG is linked to induction of Th17 cells. J Immunol. 2009;183:5654-61 pubmed publisher
    ..The data show that immunizations using the autoantigen in CpG 1826/IFA result in very low frequencies of Ag-specific IL-17 cells, suggesting a lower risk of Th17-mediated pathology when using this adjuvant. ..
  12. Zhang J, Klos M, Wilson G, Herman A, Lian X, Raval K, et al. Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method. Circ Res. 2012;111:1125-36 pubmed publisher
    ..Dynamic extracellular matrix application promoted epithelial-mesenchymal transition of human PSCs and complemented growth factor signaling to enable robust cardiac differentiation. ..
  13. Ippolito G, Dekker J, Wang Y, Lee B, Shaffer A, Lin J, et al. Dendritic cell fate is determined by BCL11A. Proc Natl Acad Sci U S A. 2014;111:E998-1006 pubmed publisher
  14. Uribe R, Gu T, Bronner M. A novel subset of enteric neurons revealed by ptf1a:GFP in the developing zebrafish enteric nervous system. Genesis. 2016;54:123-8 pubmed publisher
  15. Frazier M, Mamo L, Ghio A, Turi J. Hepcidin expression in human airway epithelial cells is regulated by interferon-?. Respir Res. 2011;12:100 pubmed publisher
    ..The presence of hepcidin in the airway does not appear to alter cellular iron transport, but may serve as a protective factor via its direct antimicrobial effects. ..
  16. Tsurutani N, Mittal P, St Rose M, Ngoi S, Svedova J, Menoret A, et al. Costimulation Endows Immunotherapeutic CD8 T Cells with IL-36 Responsiveness during Aerobic Glycolysis. J Immunol. 2016;196:124-34 pubmed publisher
    ..In summary, cytokine therapy to eliminate tumors may target effector T cells, even outside of TCR specificity, as long as the effectors are in the correct metabolic state. ..
  17. Lairmore M, Stanley J, Weber S, Holzschu D. Squamous epithelial proliferation induced by walleye dermal sarcoma retrovirus cyclin in transgenic mice. Proc Natl Acad Sci U S A. 2000;97:6114-9 pubmed
  18. Kearns A, Donohue M, Sanyal B, Demay M. Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro. J Biol Chem. 2001;276:42213-8 pubmed
    ..This novel kinase, therefore, is likely to play an important regulatory role in attenuating the program of osteoblast differentiation. ..
  19. Naganawa T, Xiao L, Abogunde E, Sobue T, Kalajzic I, Sabbieti M, et al. In vivo and in vitro comparison of the effects of FGF-2 null and haplo-insufficiency on bone formation in mice. Biochem Biophys Res Commun. 2006;339:490-8 pubmed
    ..FGF receptor2 mRNA and protein were markedly reduced in Fgf2+/- and Fgf2-/- mice. Decreased bone formation in Fgf2 mutant mice may correlate with impaired FGFR signaling, decreased Runx2 gene expression. ..
  20. Muir T, Sadler Riggleman I, Stevens J, Skinner M. Role of the basic helix-loop-helix protein ITF2 in the hormonal regulation of Sertoli cell differentiation. Mol Reprod Dev. 2006;73:491-500 pubmed
    ..Observations suggest ITF2 can enhance FSH actions through suppressing the inhibitory actions of the Id family of proteins and increasing the actions of stimulatory bHLH proteins (i.e., scleraxis) in Sertoli cells. ..
  21. Singh A, Li F, Hamazaki T, Kasahara H, Takemaru K, Terada N. Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells. Circulation. 2007;115:617-26 pubmed
    ..By revealing molecular mechanisms that control ESC-to-cardiomyocyte differentiation, this study will allow for the future development of technologies to improve cardiomyocyte differentiation from ESCs. ..
  22. Rajesh D, Chinnasamy N, Mitalipov S, Wolf D, Slukvin I, Thomson J, et al. Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells. 2007;25:490-9 pubmed
    ..Although rESCs have the potential for hematopoietic differentiation, they exhibit a pause at the hemangioblast stage of hematopoietic development in culture conditions developed for hESCs. ..
  23. Yamashita T, Yao Z, Li F, Zhang Q, Badell I, Schwarz E, et al. NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem. 2007;282:18245-53 pubmed
    ..Inhibition of NF-kappaB should prevent RANKL- and TNF-induced bone resorption. ..
  24. Parthasarathy R, Palli S. Proliferation and differentiation of intestinal stem cells during metamorphosis of the red flour beetle, Tribolium castaneum. Dev Dyn. 2008;237:893-908 pubmed publisher
    ..These data show that the proliferation of ISCs is under both developmental and endocrine regulation. ..
  25. Song I, Caplan A, Dennis J. In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo. J Orthop Res. 2009;27:916-21 pubmed publisher
    ..These results indicate that pretreatment of MSCs with dex results in greater bone formation than in untreated controls. ..
  26. Helfer J, Calizo L, Dong W, Goodlett C, Greenough W, Klintsova A. Binge-like postnatal alcohol exposure triggers cortical gliogenesis in adolescent rats. J Comp Neurol. 2009;514:259-71 pubmed publisher
    ..These findings demonstrate that neonatal alcohol exposure triggers an increase in gliogenesis in the adult motor cortex. ..
  27. Johnson M, O Connell M, Vito F, Pilcher W. Bone morphogenetic protein 4 and its receptors are expressed in the leptomeninges and meningiomas and signal via the Smad pathway. J Neuropathol Exp Neurol. 2009;68:1177-83 pubmed publisher
    ..These findings suggest that BMP-4 and BMPRs may play autocrine/paracrine roles and interact with other transforming growth factor-beta superfamily members in regulating meningioma growth and differentiation. ..
  28. Albertsen P, Moore D, Shih W, Lin Y, Li H, Lu Yao G. Impact of comorbidity on survival among men with localized prostate cancer. J Clin Oncol. 2011;29:1335-41 pubmed publisher
    ..3%) to 27.5% (95% CI, 21.5% to 36.5%). Patients and clinicians should consider using comorbidity-specific data to estimate the threat posed by newly diagnosed localized prostate cancer and the threat posed by competing medical hazards. ..
  29. Bhoopathi P, Chetty C, Dontula R, Gujrati M, Dinh D, Rao J, et al. SPARC stimulates neuronal differentiation of medulloblastoma cells via the Notch1/STAT3 pathway. Cancer Res. 2011;71:4908-19 pubmed publisher
    ..Findings show that SPARC-induced neuronal differentiation can sensitize medulloblastoma cells for therapy. ..
  30. Nelson B, Ueki Y, Reardon S, Karl M, Georgi S, Hartman B, et al. Genome-wide analysis of Müller glial differentiation reveals a requirement for Notch signaling in postmitotic cells to maintain the glial fate. PLoS ONE. 2011;6:e22817 pubmed publisher
  31. Gupta K, Gulen F, Sun L, Aguilera R, Chakrabarti A, Kiselar J, et al. GSK3 is a regulator of RAR-mediated differentiation. Leukemia. 2012;26:1277-85 pubmed publisher
    ..Overall, our studies suggest the clinical potential of ATRA and GSK3 inhibition for AML and provide a mechanistic framework to explain the promising activity of this combination regimen. ..
  32. Rockwell C, Zhang M, Fields P, Klaassen C. Th2 skewing by activation of Nrf2 in CD4(+) T cells. J Immunol. 2012;188:1630-7 pubmed publisher
    ..Further studies are needed to determine whether the commercial use of Nrf2 activators as food preservatives promotes food allergies in humans. ..
  33. Mo Y, Tang H, Miele L. Notch-associated microRNAs in cancer. Curr Drug Targets. 2013;14:1157-66 pubmed
    ..We also highlight the therapeutic potential of targeting Notch signaling and related microRNAs. ..
  34. Haldar M, Kohyama M, So A, Kc W, Wu X, Briseño C, et al. Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 2014;156:1223-1234 pubmed publisher
    ..These findings are the first example of metabolite-driven differentiation of a tissue-resident macrophage subset and provide new insights into iron homeostasis. ..
  35. Xie Y, Jin Y, Merenick B, Ding M, Fetalvero K, Wagner R, et al. Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition. Sci Signal. 2015;8:ra44 pubmed publisher
    ..Identifying the downstream transcriptional targets of mTORC1 may provide cell type-specific drug targets to combat cardiovascular diseases associated with excessive proliferation of VSMCs. ..
  36. Decker R, Um H, Dyment N, Cottingham N, Usami Y, Enomoto Iwamoto M, et al. Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. Dev Biol. 2017;426:56-68 pubmed publisher
    ..Synovial Prg4+ lineage progenitors are exquisitely responsive to acute injury and may represent pioneers in joint tissue repair. ..
  37. Miner J, Miller J, Wold B. Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart. Development. 1992;114:853-60 pubmed
  38. Ehrlich G, Han T, Bettigole R, Merl S, Lehr B, Tomar R, et al. Human T-lymphotropic virus type I-associated benign transient immature T-cell lymphocytosis. Am J Hematol. 1988;27:49-55 pubmed
    ..The patient's HTLV-I markers disappeared with time, and her lymphocytosis subsequently spontaneously resolved. She remains disease free and virus negative after 2 years of follow-up study. ..
  39. Zhou G, Seibenhener M, Wooten M. Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells. J Biol Chem. 1997;272:31130-7 pubmed
    ..Taken together, the findings presented herein document that nucleolin is a target of PKC-zeta that serves to relay NGF signals from cell surface to nucleus in PC12 cells. ..
  40. Liu Y, Hair G, Boden S, Viggeswarapu M, Titus L. Overexpressed LIM mineralization proteins do not require LIM domains to induce bone. J Bone Miner Res. 2002;17:406-14 pubmed
    ..These findings suggest that the LIM domains are not required for LMPs to induce bone formation. In addition, a small region (36 AA) of the LMP-1 protein may be required for bone formation. ..
  41. Chen Y, Perry D, Boackle S, Sobel E, Molina H, Croker B, et al. Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c. J Immunol. 2005;175:1080-9 pubmed
  42. Crish J, Gopalakrishnan R, Bone F, Gilliam A, Eckert R. The distal and proximal regulatory regions of the involucrin gene promoter have distinct functions and are required for in vivo involucrin expression. J Invest Dermatol. 2006;126:305-14 pubmed
    ..These studies suggest that AP1, Sp1, and C/EBP transcription factors are required for appropriate differentiation-dependent involucrin expression, and that the mechanism of regulation is similar in most surface epithelia. ..
  43. Zhang M, Yan Y, Lim Y, Tang D, Xie R, Chen A, et al. BMP-2 modulates beta-catenin signaling through stimulation of Lrp5 expression and inhibition of beta-TrCP expression in osteoblasts. J Cell Biochem. 2009;108:896-905 pubmed publisher
    ..These findings suggest that BMP-2 may regulate osteoblast function in part through modulation of the beta-catenin signaling. ..
  44. Xiao Z, Zhang S, Cao L, Qiu N, David V, Quarles L. Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation. J Biol Chem. 2010;285:1177-87 pubmed publisher
    ..The conditional deletion of Pkd1 also resulted in increased adipogenesis in bone marrow and in osteoblast cultures. Thus, PKD1 directly functions in osteoblasts to regulate bone formation. ..
  45. Zheng Y, Josefowicz S, Chaudhry A, Peng X, Forbush K, Rudensky A. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature. 2010;463:808-12 pubmed publisher
    ..Together, our studies demonstrate that the composition, size and maintenance of the T(reg) cell population are controlled by Foxp3 CNS elements engaged in response to distinct cell-extrinsic or -intrinsic cues. ..
  46. Morgan C, Lee M, Kimble J. Chemical reprogramming of Caenorhabditis elegans germ cell fate. Nat Chem Biol. 2010;6:102-4 pubmed publisher
    ..These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell reprogramming. ..
  47. Wang L, Shao Y, Ballock R. Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of beta-catenin signaling. J Bone Miner Res. 2010;25:1138-46 pubmed publisher
  48. Crocker S, Bajpai R, Moore C, Frausto R, Brown G, Pagarigan R, et al. Intravenous administration of human embryonic stem cell-derived neural precursor cells attenuates cuprizone-induced central nervous system (CNS) demyelination. Neuropathol Appl Neurobiol. 2011;37:643-53 pubmed publisher
    ..Observed reductions in astrocyte and microglial responses, and the benefit of hES-NPC treatment in this model of myelin injury was not obviously accountable to tissue replacement by exogenously administered cells. ..
  49. Ortega M, Xie L, Mora S, Chapes S. Evaluation of macrophage plasticity in brown and white adipose tissue. Cell Immunol. 2011;271:124-33 pubmed publisher
    ..These data suggest that the C2D macrophage phenotype can change rapidly and distinct phenotypes are induced by different microenvironments. ..
  50. Wong H, Mishra A, Hake T, Porcu P. Evolving insights in the pathogenesis and therapy of cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome). Br J Haematol. 2011;155:150-66 pubmed publisher
    ..This review summarizes the clinical epidemiology, staging and natural history of MF and SS; discusses the immunopathogenesis of MF and the functional role of the malignant T-cells; and reviews the latest advances in MF and SS treatment...
  51. Lovat F, Valeri N, Croce C. MicroRNAs in the pathogenesis of cancer. Semin Oncol. 2011;38:724-33 pubmed publisher
    ..The work aims at providing the molecular bases for the understanding of the potential role of miRs in the translational and clinical setting. ..
  52. Ratajczak M, Kucia M, Jadczyk T, Greco N, Wojakowski W, Tendera M, et al. Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?. Leukemia. 2012;26:1166-73 pubmed publisher
    ..This approach may yield critical improvements in current cell therapies before true pluripotent stem cells isolated in sufficient quantities from adult tissues and successfully expanded ex vivo will be employed in the clinic. ..
  53. Levin M. Molecular bioelectricity in developmental biology: new tools and recent discoveries: control of cell behavior and pattern formation by transmembrane potential gradients. Bioessays. 2012;34:205-17 pubmed publisher
    ..This will enable fundamental advances in basic understanding of growth and form, as well as transformative biomedical applications in regenerative medicine. ..
  54. Mis E, Liem K, Kong Y, Schwartz N, Domowicz M, Weatherbee S. Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length. Dev Biol. 2014;385:67-82 pubmed publisher
    ..The pug mutant serves as a novel model for mammalian dwarfism and identifies a key role for proteoglycan modification in the initiation of chondrocyte maturation. ..
  55. Xu Y, Fu M, Li Z, Fan Z, Li X, Liu Y, et al. A prosurvival and proangiogenic stem cell delivery system to promote ischemic limb regeneration. Acta Biomater. 2016;31:99-113 pubmed publisher
    ..Meanwhile, the differentiation of stem cells into endothelial and myogenic lineages, and cell paracrine effects will enhance vascularization and muscle regeneration. ..
  56. Chen X, Meyerowitz E. HUA1 and HUA2 are two members of the floral homeotic AGAMOUS pathway. Mol Cell. 1999;3:349-60 pubmed
    ..Molecular analyses suggest that HUA2 (and possibly HUA1) acts to facilitate AG action at the same hierarchical level as AG. ..
  57. Sterling K, Cutroneo K. Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis. J Cell Biochem. 2002;86:440-50 pubmed
  58. Rothenberg E, Pant R. Origins of lymphocyte developmental programs: transcription factor evidence. Semin Immunol. 2004;16:227-38 pubmed
    ..We consider the functions of these factors in animals without lymphocytes in terms of discrete program components, which could have been assembled in a new way to create the lymphocyte developmental program approximately 500 My ago. ..
  59. Wang L, Shao Y, Ballock R. Peroxisome proliferator activated receptor-gamma (PPARgamma) represses thyroid hormone signaling in growth plate chondrocytes. Bone. 2005;37:305-12 pubmed
    ..The molecular mechanism involved in this inhibition appears to be competition between PPARgamma and TRalpha for limiting amounts of the heterodimeric partner RXR. ..
  60. Kawagoe H, Grosveld G. MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice. Blood. 2005;106:4278-86 pubmed
  61. Bruggeman L, Martinka S, Simske J. Expression of TM4SF10, a Claudin/EMP/PMP22 family cell junction protein, during mouse kidney development and podocyte differentiation. Dev Dyn. 2007;236:596-605 pubmed
    ..TM4SF10 may define a new class of Claudin-like proteins that function during junctional development. ..
  62. Slavik M, Allen Hoffmann B, Liu B, Alexander C. Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures. BMC Dev Biol. 2007;7:9 pubmed
    ..Since it is known that canonical ligands are expressed in skin, it is likely that this pathway normally regulates the balance of growth and differentiation, and suggests it could be important to pathogenesis. ..
  63. Dhar S, Yoon E, Kachgal S, Evans G. Long-term maintenance of neuronally differentiated human adipose tissue-derived stem cells. Tissue Eng. 2007;13:2625-32 pubmed
    ..The data show that our DE-1 medium is capable of achieving a greater number of differentiated ADSCs for a longer period of time. This result bodes well for the application of ADSCs in in vivo peripheral nerve regeneration. ..
  64. Yasuhara T, Hara K, Maki M, Masuda T, Sanberg C, Sanberg P, et al. Dietary supplementation exerts neuroprotective effects in ischemic stroke model. Rejuvenation Res. 2008;11:201-14 pubmed publisher
    ..These data demonstrate the remarkable neuroprotective effects of NT-020 when given prior to stroke, possibly acting via its neurogenic potential. ..
  65. Kurusu M, Zinn K. Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body. Mol Cell Neurosci. 2008;38:53-65 pubmed publisher
    ..Lar and Ptp69D are necessary for the axonal branching decisions that create the lobes. Avoidance of the brain midline by extending medial lobe axons involves signaling through Lar. ..
  66. Jin J, Li Q, Higashi Y, Darling D, Ding J. Analysis of Zfhx1a mutant mice reveals palatal shelf contact-independent medial edge epithelial differentiation during palate fusion. Cell Tissue Res. 2008;333:29-38 pubmed publisher
    ..5 in a contact-independent manner, suggesting that differentiation of the medial edge epithelium was largely programmed through an intrinsic mechanism within the palate shelf. ..
  67. Fields A, Calcagno S, Krishna M, Rak S, Leitges M, Murray N. Protein kinase Cbeta is an effective target for chemoprevention of colon cancer. Cancer Res. 2009;69:1643-50 pubmed publisher
    ..Thus, PKCbetaII is an important target for colon cancer chemoprevention and the PKCbeta-selective inhibitor enzastaurin may represent an effective chemopreventive agent in patients at high risk for colon cancer. ..
  68. Mishra P, Singh S, Joshua I, Tyagi S. Stem cells as a therapeutic target for diabetes. Front Biosci (Landmark Ed). 2010;15:461-77 pubmed
    ..In this review we discussed stem cells as a potential future therapeutic target for the treatment of diabetes and associated diseases. ..
  69. Thompson A, Levin L. Neuronal differentiation by analogs of staurosporine. Neurochem Int. 2010;56:554-60 pubmed publisher
    ..Given that UCN-01 and similar compounds are potent anti-cancer drugs, examination of molecules that share similar structural features may yield insights into the design of other drugs for differentiation. ..
  70. Li N, Sarojini H, An J, Wang E. Prosaposin in the secretome of marrow stroma-derived neural progenitor cells protects neural cells from apoptotic death. J Neurochem. 2010;112:1527-38 pubmed publisher
    ..We suggest that upon injury, a subgroup of MSCs differentiates into neural/neuronal progenitor cells, and remains in this intermediate stem cell-like stage, defending injured neighboring mature neurons from apoptosis by secreting PSAP. ..
  71. Mailankot M, Howell S, Nagaraj R. Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells. Biochim Biophys Acta. 2010;1802:609-20 pubmed publisher
    ..Together our data suggest that KYN might inhibit FGF2-mediated fiber cell differentiation by preventing expression of crystallins and MIP26. Our studies provide a novel mechanism by which KYN can exert deleterious effects in cells. ..
  72. Nguyen H, Barlow L. Differential expression of a BMP4 reporter allele in anterior fungiform versus posterior circumvallate taste buds of mice. BMC Neurosci. 2010;11:129 pubmed publisher
  73. Tran T, Jarrell A, Zentner G, Welsh A, Brownell I, Scacheri P, et al. Role of canonical Wnt signaling/ß-catenin via Dermo1 in cranial dermal cell development. Development. 2010;137:3973-84 pubmed publisher
    ..This study reveals a lineage-specific role of canonical Wnt signaling/?-catenin in promoting dermal cell fate in distinct precursor populations...
  74. Chang M, Chan C, Braun K, Green P, O Brien K, Chait A, et al. Monocyte-to-macrophage differentiation: synthesis and secretion of a complex extracellular matrix. J Biol Chem. 2012;287:14122-35 pubmed publisher
  75. Quinn K, Bellas E, Fourligas N, Lee K, Kaplan D, Georgakoudi I. Characterization of metabolic changes associated with the functional development of 3D engineered tissues by non-invasive, dynamic measurement of individual cell redox ratios. Biomaterials. 2012;33:5341-8 pubmed publisher
  76. Conway G, O Bara M, Vedia B, Pol S, Sim F. Histone deacetylase activity is required for human oligodendrocyte progenitor differentiation. Glia. 2012;60:1944-53 pubmed publisher
    ..2012 Wiley Periodicals, Inc. ..
  77. Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, et al. Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther. 2013;21:228-39 pubmed publisher
    ..Thus, comprehensive fingerprinting of individual clones is mandatory to secure homogenous pools amenable for diagnostic and therapeutic applications of iPS cells from patients with T1D. ..
  78. Del Real M, Rothenberg E. Architecture of a lymphomyeloid developmental switch controlled by PU.1, Notch and Gata3. Development. 2013;140:1207-19 pubmed publisher
    ..We show that maintenance of Gata3 protein levels by Myb and Notch signaling is linked to the ability to retain T-cell identity in response to PU.1. ..
  79. Rendina E, Hembree K, Davis M, Marlow D, Clarke S, Halloran B, et al. Dried plum's unique capacity to reverse bone loss and alter bone metabolism in postmenopausal osteoporosis model. PLoS ONE. 2013;8:e60569 pubmed publisher
    ..These alterations in bone metabolism and antioxidant status compared to other dried fruits provide insight into dried plum's unique effects on bone. ..
  80. Higgins D, Wang R, Milligan B, Schroeder M, Carlson B, Pokorny J, et al. Brain tumor stem cell multipotency correlates with nanog expression and extent of passaging in human glioblastoma xenografts. Oncotarget. 2013;4:792-801 pubmed
    ..Thus, nanog may identify multipotent BTSCs. Furthermore, limited passaging of xenografts preserves these multipotent BTSCs, which may be an essential underlying feature of GBM lethality. ..
  81. Riazifar H, Jia Y, Chen J, Lynch G, Huang T. Chemically induced specification of retinal ganglion cells from human embryonic and induced pluripotent stem cells. Stem Cells Transl Med. 2014;3:424-32 pubmed publisher
    ..In combination, these data demonstrate that a single chemical (DAPT) can induce PAX6/RX-positive stem cells to undergo differentiation into functional RGCs. ..
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