Experts and Doctors on cell cycle proteins in United States

Summary

Locale: United States
Topic: cell cycle proteins

Top Publications

  1. Barry C, Xie J, Lemmon V, Young A. Molecular characterization of a multi-promoter gene encoding a chicken filamin protein. J Biol Chem. 1993;268:25577-86 pubmed
    ..A second filamin promoter (Fil2) is located at least 8 kilobases upstream from the Fil1 promoter. This structural arrangement suggests that regulation of filamin gene expression is likely to be complex. ..
  2. Sullivan D, Biggins S, Rose M. The yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, are required for cell integrity. J Cell Biol. 1998;143:751-65 pubmed
    ..We postulate that Cdc31p is required both for SPB duplication and for cell integrity/morphogenesis, and that the integrity/morphogenesis function is mediated through the Kic1p protein kinase. ..
  3. Li Y, Wang X, Zhang X, Goodrich D. Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. Mol Cell Biol. 2005;25:4023-33 pubmed
    ..We conclude that hHpr1/p84/Thoc1 regulates transcriptional elongation and may participate in a protein complex functionally analogous to yeast TREX, physically linking elongating RNA polymerase II with RNA processing factors. ..
  4. Yuan L, Yu W, Xu M, Qu C. SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively. J Biol Chem. 2005;280:42701-6 pubmed
    ..Collectively, these studies have further defined the mechanisms by which SHP-2 phosphatase regulates DNA damage responses. ..
  5. Lee J, Kumagai A, Dunphy W. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J Biol Chem. 2007;282:28036-44 pubmed
    ..These findings suggest that interaction of the 9-1-1 complex with the BRCT I-II region of TopBP1 is necessary for binding of ATR-ATRIP to the ATR-activating domain of TopBP1 and the ensuing activation of ATR. ..
  6. Zhang Y, Brognard J, Coughlin C, You Z, Dolled Filhart M, Aslanian A, et al. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol Cell. 2009;35:442-53 pubmed publisher
    ..We propose that Fbx6-dependent Chk1 degradation contributes to S phase checkpoint termination and that a defect in this mechanism might increase tumor cell resistance to certain anticancer drugs. ..
  7. Akakura S, Nochajski P, Gao L, Sotomayor P, Matsui S, Gelman I. Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12. Cell Cycle. 2010;9:4656-65 pubmed
    ..Our data strongly suggest that Akap12 controls Rb-mediated cell aging and oncogenic progression by directly scaffolding and attenuating PKC?/?. ..
  8. Cholewa B, Liu X, Ahmad N. The role of polo-like kinase 1 in carcinogenesis: cause or consequence?. Cancer Res. 2013;73:6848-55 pubmed publisher
    ..However, evidence supports the notion that oncogene dependence on Plk1 is not a late occurrence in carcinogenesis and it is likely that Plk1 plays an active role in carcinogenic transformation. ..
  9. Mueller P, Coleman T, Kumagai A, Dunphy W. Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science. 1995;270:86-90 pubmed
    ..Myt1 activity is highly regulated during the cell cycle, suggesting that this relative of Wee1 plays a role in mitotic control. ..

More Information

Publications568 found, 100 shown here

  1. Kakar S, Jennes L. Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis. Cytogenet Cell Genet. 1999;84:211-6 pubmed
    ..These results suggest that TUTR1 is a novel and potent transforming gene, which may be involved in tumorigenesis in numerous different human tumors. ..
  2. Muscarella P, Knobloch T, Ulrich A, Casto B, Moniaux N, Wittel U, et al. Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16(INK4a) and p15(INK4b) cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells. Gene. 2001;278:235-43 pubmed
  3. Ren M, Santhanam A, Lee P, Caplan A, Garrett S. Alteration of the protein kinase binding domain enhances function of the Saccharomyces cerevisiae molecular chaperone Cdc37. Eukaryot Cell. 2007;6:1363-72 pubmed
  4. Datta A, Silverman L, Phipps A, Hiraragi H, Ratner L, Lairmore M. Human T-lymphotropic virus type-1 p30 alters cell cycle G2 regulation of T lymphocytes to enhance cell survival. Retrovirology. 2007;4:49 pubmed
  5. Lee B, Almad A, Butcher G, Obrietan K. Protein kinase C modulates the phase-delaying effects of light in the mammalian circadian clock. Eur J Neurosci. 2007;26:451-62 pubmed
    ..Thus, PKC may influence clock entrainment via a post-translational mechanism that influences clock protein stability. ..
  6. HICKS S, Lewis L, Ritchie J, Burke P, Abdul Malak Y, Adackapara N, et al. Evaluation of cell proliferation, apoptosis, and DNA-repair genes as potential biomarkers for ethanol-induced CNS alterations. BMC Neurosci. 2012;13:128 pubmed publisher
  7. Whitney M, Saito H, Jakobs P, Gibson R, Moses R, Grompe M. A common mutation in the FACC gene causes Fanconi anaemia in Ashkenazi Jews. Nat Genet. 1993;4:202-5 pubmed
    ..Three additional Jewish patients bearing this allele were found upon screening 21 other families. We conclude that a common mutation in FACC accounts for the majority of Fanconi anaemia in Ashkenazi-Jewish families. ..
  8. Liu Z, Mukherjee A, Lutkenhaus J. Recruitment of ZipA to the division site by interaction with FtsZ. Mol Microbiol. 1999;31:1853-61 pubmed
    ..These results are consistent with ZipA acting after Z ring formation, possibly to link the membrane to FtsZ filaments during invagination of the septum...
  9. Yang H, Jiang W, Gentry M, Hallberg R. Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradation. Mol Cell Biol. 2000;20:8143-56 pubmed
    ..We also present evidence indicating that, in cdc55-null cells, misregulated PP2A phosphatase activity is the cause of both the ectopic stabilization of Swe1p and the production of the morphologically abnormal phenotype. ..
  10. Yamane K, Taylor K, Kinsella T. Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway. Biochem Biophys Res Commun. 2004;318:297-302 pubmed
    ..Our results indicate that 6-TG DNA mismatches activate the ATR-Chk1 pathway in the MMR(+) cells, resulting in a G2/M checkpoint response ..
  11. Yin G, Zheng Q, Yan C, Berk B. GIT1 is a scaffold for ERK1/2 activation in focal adhesions. J Biol Chem. 2005;280:27705-12 pubmed
    ..In summary, the present study further supports a key role for GIT1 (a MEK1-binding protein) as a scaffold for signal transduction in focal adhesions. ..
  12. Su N, Kilberg M. C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J Biol Chem. 2008;283:35106-17 pubmed publisher
    ..Collectively, the results document that CHOP is a member of the transcription factor network that controls the stress-induced regulation of specific C/EBP-ATF-containing genes, such as ASNS. ..
  13. Butler J, Moore M, Presnell S, Chan H, Chalupny N, Lutz C. Proteasome regulation of ULBP1 transcription. J Immunol. 2009;182:6600-9 pubmed publisher
    ..The selective induction of ULBP1 expression by proteasome inhibitor drugs, along with variable NKG2D ligand expression by human tumor cells, indicates that NKG2D ligand genes are independently regulated. ..
  14. Metz R, Yehia G, Fernandes H, Donnelly R, Rameshwar P. Cloning and characterization of the 5' flanking region of the HGFIN gene indicate a cooperative role among p53 and cytokine-mediated transcription factors: relevance to cell cycle regulation. Cell Cycle. 2005;4:315-22 pubmed
    ..In summary, p53 cooperate with cytokine-mediated transcription factors to regulate the expression of HGFIN. ..
  15. Swan A, Schupbach T. Drosophila female meiosis and embryonic syncytial mitosis use specialized Cks and CDC20 proteins for cyclin destruction. Cell Cycle. 2005;4:1332-4 pubmed
    ..These results indicate that anaphase progression in female meiosis and the early embryo are under unique control in Drosophila. ..
  16. Moffat J, Greenblatt R. Effects of varicella-zoster virus on cell cycle regulatory pathways. Curr Top Microbiol Immunol. 2010;342:67-77 pubmed publisher
    ..Some of these perturbed cell functions are essential for VZV replication, such as cyclin-dependent kinase (CDK) activity, and reveal targets for interventions. ..
  17. Hale C, Shiomi D, Liu B, Bernhardt T, Margolin W, Niki H, et al. Identification of Escherichia coli ZapC (YcbW) as a component of the division apparatus that binds and bundles FtsZ polymers. J Bacteriol. 2011;193:1393-404 pubmed publisher
    ..This and additional evidence indicate that, like ZapA, ZapC is a nonessential Z-ring component that contributes to the efficiency of the division process by stabilizing the polymeric form of FtsZ. ..
  18. Akizu N, Silhavy J, Rosti R, Scott E, Fenstermaker A, Schroth J, et al. Mutations in CSPP1 lead to classical Joubert syndrome. Am J Hum Genet. 2014;94:80-6 pubmed publisher
    ..Here, we show abrogated protein levels and ciliogenesis in affected fibroblasts. Our data thus suggest that CSPP1 is involved in neural-specific functions of primary cilia. ..
  19. McMahon L, Walsh C, Lambert M. Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex. J Biol Chem. 1999;274:32904-8 pubmed
    ..alphaSpIISigma* may thus act as a scaffold to align or enhance interactions between FA proteins and proteins involved in DNA repair. These results suggest that FA represents a disorder in which there is a deficiency in alphaSpIISigma*. ..
  20. Shou W, Deshaies R. Multiple telophase arrest bypassed (tab) mutants alleviate the essential requirement for Cdc15 in exit from mitosis in S. cerevisiae. BMC Genet. 2002;3:4 pubmed
    ..Transport-defective mutations in two karyopherins can bypass cdc15Delta, suggesting that the function of the MEN is to promote mitotic exit by regulating nuclear transport. ..
  21. Elsherif L, Jiang Y, Saari J, Kang Y. Dietary copper restriction-induced changes in myocardial gene expression and the effect of copper repletion. Exp Biol Med (Maywood). 2004;229:616-22 pubmed
    ..The return to normal cardiac function by CuR may be a result of the favorable regression in gene expression of these critical components in myocardial tissue. ..
  22. Streb J, Miano J. AKAP12alpha, an atypical serum response factor-dependent target gene. J Biol Chem. 2005;280:4125-34 pubmed
    ..Furthermore, we provide new insight into the role of flanking sequences in determining sensitivity to SRF-myocardin activity. ..
  23. Asiedu M, Wu D, Matsumura F, Wei Q. Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle. Mol Biol Cell. 2009;20:1428-40 pubmed publisher
    ..Therefore, we propose that CSPP interacts with and recruits MyoGEF to the central spindle, where MyoGEF contributes to the spatiotemporal regulation of cytokinesis. ..
  24. Lee S, Langhans S. Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis. BMC Cancer. 2012;12:44 pubmed publisher
  25. Li Y, Xiong H, Yang D. Functional switching of ATM: sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells. Chin J Cancer. 2012;31:364-72 pubmed publisher
    ..These results demonstrate that ATM mediates the Akt signaling and promotes cell survival in neuron-like human SH-SY5Y cells, suggesting that impaired activation of Akt is the reason for neuronal degeneration in human A-T. ..
  26. Stubblefield K, Chean J, Nguyen T, Chen C, Shively J. The adaptor SASH1 acts through NOTCH1 and its inhibitor DLK1 in a 3D model of lumenogenesis involving CEACAM1. Exp Cell Res. 2017;359:384-393 pubmed publisher
  27. Snider L, Thirlwell H, Miller J, Moon R, Groudine M, Tapscott S. Inhibition of Tcf3 binding by I-mfa domain proteins. Mol Cell Biol. 2001;21:1866-73 pubmed
    ..I-mfa domain proteins can regulate both the Wnt signaling pathway and a subset of bHLH proteins, possibly coordinating the activities of these two critical developmental pathways. ..
  28. Shepherd E, Zhao Q, Welty S, Hansen T, Smith C, Liu Y. The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages. J Biol Chem. 2004;279:54023-31 pubmed
    ..7 cells and further suggest a central role for this phosphatase in controlling the inflammatory responses of primary macrophages to Gram-positive bacterial infection. ..
  29. Balasubramanian S, Chandraratna R, Eckert R. A novel retinoid-related molecule inhibits pancreatic cancer cell proliferation by a retinoid receptor independent mechanism via suppression of cell cycle regulatory protein function and induction of caspase-associated apoptosis. Oncogene. 2005;24:4257-70 pubmed
    ..AGN193198 produces similar responses in other pancreatic cancer cell lines including AsPC-1 and MIA PaCa-2. These studies suggest that AGN193198 may be useful for the treatment of pancreatic cancer. ..
  30. Lu Q, Wang D, Chen C, Hu Y, Chen C. Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005;48:5530-5 pubmed
    ..S)-11 at concentrations as low as 0.1 microM was effective in causing histone hyperacetylation and p21(WAF/CIP1) overexpression and suppressing proliferation in cancer cells. ..
  31. Kuninger D, Wright A, Rotwein P. Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity. Am J Physiol Cell Physiol. 2006;291:C699-709 pubmed
    ..Our results define a role for p300 in promoting cell survival, which is independent of its acetyltransferase activity and acts at least in part through FGF-1. ..
  32. Kitareewan S, Blumen S, Sekula D, Bissonnette R, Lamph W, Cui Q, et al. G0S2 is an all-trans-retinoic acid target gene. Int J Oncol. 2008;33:397-404 pubmed
    ..Taken together, these findings indicate G0S2 is an RA target gene. The functional role of G0S2 in retinoid response of APL warrants further study. ..
  33. Saldivar J, Bene J, Hosseini S, Miuma S, Horton S, Heerema N, et al. Characterization of the role of Fhit in suppression of DNA damage. Adv Biol Regul. 2013;53:77-85 pubmed publisher
    ..These findings provide important and unexpected insights into the mechanism whereby loss of Fhit expression contributes to cell transformation. ..
  34. Kim T, Cutry A, Kinniburgh A, Wenner C. Transforming growth factor beta 1-induced delay of cell cycle progression and its association with growth-related gene expression in mouse fibroblasts. Cancer Lett. 1993;71:125-32 pubmed
    ..These results first demonstrate that the delay of cell cycle progression by TGF beta is closely associated with the altered regulation of growth-related gene expression in fibroblasts. ..
  35. Neufeld T, de la Cruz A, Johnston L, Edgar B. Coordination of growth and cell division in the Drosophila wing. Cell. 1998;93:1183-93 pubmed
    ..We infer that dE2F and RBF function specifically in cell cycle control, and that cell cycle acceleration is insufficient to stimulate growth. Variations in dE2F activity could be used to coordinate cell division with growth. ..
  36. Mal A, Sturniolo M, Schiltz R, Ghosh M, Harter M. A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program. EMBO J. 2001;20:1739-53 pubmed
    ..These results provide for a model which postulates that MyoD may be co-dependent on HDAC1 and P/CAF for temporally controlling its transcriptional activity before and after the differentiation of muscle cells. ..
  37. Gordo A, He C, Smith S, Fissore R. Mitogen activated protein kinase plays a significant role in metaphase II arrest, spindle morphology, and maintenance of maturation promoting factor activity in bovine oocytes. Mol Reprod Dev. 2001;59:106-14 pubmed
    ..In summary, our results demonstrate that in bovine oocytes MAPK activity is required for MII arrest, maintenance of MPF activity, and spindle organization. ..
  38. Bromidge T, Lynas C. Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies. Leuk Res. 2002;26:631-5 pubmed
    ..This study suggests that neither perturbation of alternative splicing, nor mutation of p33/ING1 plays a significant role in the development of haematological malignancies. ..
  39. Zhang Z, Li J, Lantry L, Wang Y, Wiseman R, Lubet R, et al. p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas. Cancer Res. 2002;62:3024-9 pubmed
    ..These results demonstrate a tissue-specific enhancement of tumorigenesis in multiple organs by the mutant p53 transgene and additionally support the utility of (C57BL/6J x UL53-3) F(1) mice for chemoprevention studies. ..
  40. Jin Y, Zeng S, Dai M, Yang X, Lu H. MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation. J Biol Chem. 2002;277:30838-43 pubmed
    ..These results demonstrate that MDM2 can inhibit PCAF-mediated p53 acetylation and activation. ..
  41. Kuhlman S, Silver R, Le Sauter J, Bult Ito A, McMahon D. Phase resetting light pulses induce Per1 and persistent spike activity in a subpopulation of biological clock neurons. J Neurosci. 2003;23:1441-50 pubmed
  42. Liu X, Tesfai J, Evrard Y, Dent S, Martinez E. c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J Biol Chem. 2003;278:20405-12 pubmed
    ..Thus, TRRAP might function as an adaptor within the STAGA complex, which helps recruit GCN5 HAT activity to Myc during transcription activation. ..
  43. Fernandez Zapico M, Gonzalez Paz N, Weiss E, Savoy D, Molina J, Fonseca R, et al. Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Cancer Cell. 2005;7:39-49 pubmed
    ..Thus, the discovery of prooncogenic pathways regulated by Vav1 makes it an attractive target for therapeutic intervention. ..
  44. Thomas M, Chiang C. E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradation. Mol Cell. 2005;17:251-64 pubmed publisher
  45. Mercer S, Ewton D, Deng X, Lim S, Mazur T, Friedman E. Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts. J Biol Chem. 2005;280:25788-801 pubmed
    ..Endogenous p21 localized exclusively to the nuclei of proliferating myoblasts but was also found in the cytoplasm of post-mitotic multinucleated myotubes and adult human skeletal myofibers. ..
  46. Maine E, Hauth J, Ratliff T, Vought V, She X, Kelly W. EGO-1, a putative RNA-dependent RNA polymerase, is required for heterochromatin assembly on unpaired dna during C. elegans meiosis. Curr Biol. 2005;15:1972-8 pubmed
    ..ego-1 interacts genetically with him-17, another regulator of chromatin and meiosis, to promote germline development. We conclude that EGO-1 is an essential component of meiotic silencing in C. elegans. ..
  47. Shanware N, Trinh A, Williams L, Tibbetts R. Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage. J Biol Chem. 2007;282:6283-91 pubmed
    ..The coregulated ATM and CK sites identified in CREB may constitute a signaling motif that is common to other DNA damage-regulated substrates. ..
  48. Lee K, Adhikary G, Balasubramanian S, Gopalakrishnan R, McCormick T, Dimri G, et al. Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis. J Invest Dermatol. 2008;128:9-17 pubmed
    ..Such a function would help assure proper formation of the stratified epidermis. ..
  49. Gong F, Fahy D, Liu H, Wang W, Smerdon M. Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damage. Cell Cycle. 2008;7:1067-74 pubmed
    ..These results also indicate that Swi/Snf may modulate checkpoint activation after UV damage via regulation of the two PCNA-binding proteins Gadd45a and p21. ..
  50. Wu Z, Miyamoto S. Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress. EMBO J. 2008;27:1963-73 pubmed publisher
    ..Thus, replication stress and DSB inducers activate NF-kappaB through a conserved pathway with opposite biologic outcomes, and ATR antagonizes ATM function at least in part by competing for NEMO association. ..
  51. Greeson N, Sengupta R, Arida A, Jenuwein T, Sanders S. Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage. J Biol Chem. 2008;283:33168-74 pubmed publisher
    ..These results argue that the di-methyl H4K20 modification serves as a binding target that directs Crb2 to sites of genomic lesions and defines an important genome integrity pathway mediated by a specific methyl-lysine histone mark. ..
  52. Small V, Chuang C, Nugent C. Rad24 truncation, coupled with altered telomere structure, promotes cdc13-1 suppression in S. cerevisiae. Cell Cycle. 2008;7:3428-39 pubmed
    ..Our hypothesis is that the Rad24-2 truncation protein affects telomere structure or recombination in a manner distinct from rad24-delta. ..
  53. Jiang W, Jiang C, Pei H, Wang L, Zhang J, Hu H, et al. In vivo molecular mediators of cancer growth suppression and apoptosis by selenium in mammary and prostate models: lack of involvement of gadd genes. Mol Cancer Ther. 2009;8:682-91 pubmed publisher
    ..They cast doubt on the three gadd genes as mediators of Se action in vivo. ..
  54. Sobeck A, Stone S, Landais I, de Graaf B, Hoatlin M. The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways. J Biol Chem. 2009;284:25560-8 pubmed publisher
    ..Our results indicate that functions of FANCM are controlled by FA- and non-FA pathways in the DNA damage response. ..
  55. Feng W, Bachant J, Collingwood D, Raghuraman M, Brewer B. Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress. Genetics. 2009;183:1249-60 pubmed publisher
    ..Our results highlight the importance of replicating yeast centromeres early and reveal different mechanisms of cell death due to differences in replication fork progression...
  56. Balasubramanian D, Scacheri P. Functional studies of menin through genetic manipulation of the Men1 homolog in mice. Adv Exp Med Biol. 2009;668:105-15 pubmed
  57. Choi H, Zhu B. Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol. Biochim Biophys Acta. 2012;1823:1306-15 pubmed publisher
    ..In conclusion, treatment of human cancer cells with 2ME(2) causes up-regulation of cyclin B1 and Cdc2, which then mediate the induction of mitotic prometaphase arrest. ..
  58. Aydin I, Melamed R, Adams S, Castillo Martin M, Demir A, Bryk D, et al. FBXW7 mutations in melanoma and a new therapeutic paradigm. J Natl Cancer Inst. 2014;106:dju107 pubmed publisher
  59. Zhang Y, Rowland S, King G, Braswell E, Rothfield L. The relationship between hetero-oligomer formation and function of the topological specificity domain of the Escherichia coli MinE protein. Mol Microbiol. 1998;30:265-73 pubmed
    ..The interference with normal septal placement is ascribed to competition between MinE36-88 and the corresponding domain in the complete MinE protein for a component required for the topological specificity of septal placement. ..
  60. Chong J, Chuang R, Tung L, Chang T. Ded1p, a conserved DExD/H-box translation factor, can promote yeast L-A virus negative-strand RNA synthesis in vitro. Nucleic Acids Res. 2004;32:2031-8 pubmed
  61. Butcher G, Lee B, Cheng H, Obrietan K. Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism. J Neurosci. 2005;25:5305-13 pubmed
    ..Together, these data identify MSK1 as both a downstream target of the MAPK cascade within the SCN and a regulator of clock gene expression. ..
  62. Nakada D, Hirano Y, Tanaka Y, Sugimoto K. Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage. Mol Biol Cell. 2005;16:5227-35 pubmed
    ..Our findings support the model in which Mec1 and Ddc2 localize to sites of DNA damage by interacting with RPA in the form of the Mec1-Ddc2 complex. ..
  63. Wu Z, Shi Y, Tibbetts R, Miyamoto S. Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science. 2006;311:1141-6 pubmed
    ..Thus, regulated nuclear shuttling of NEMO links two signaling kinases, ATM and IKK, to activate NF-kappaB by genotoxic signals. ..
  64. Illuzzi J, Yerkes S, Parekh Olmedo H, Kmiec E. DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates. J Neurosci Res. 2009;87:733-47 pubmed publisher
    ..Because these events can lead to apoptosis, it is possible that the DNA damage response pathway activated by single- and double-strand breaks that we found contributes to neurodegeneration. ..
  65. Wood P, Yang X, Taber A, Oh E, Ansell C, Ayers S, et al. Period 2 mutation accelerates ApcMin/+ tumorigenesis. Mol Cancer Res. 2008;6:1786-93 pubmed publisher
  66. Vissinga C, Yeo T, Warren S, Brawley J, Phillips J, Cerosaletti K, et al. Nuclear export of NBN is required for normal cellular responses to radiation. Mol Cell Biol. 2009;29:1000-6 pubmed publisher
  67. Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen J, et al. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol. 2008;10:1076-82 pubmed publisher
    ..Thus, Plk1-dependent regulation of FoxM1 activity provides a positive-feedback loop ensuring tight regulation of transcriptional networks essential for orderly mitotic progression. ..
  68. Kaur M, Velmurugan B, Tyagi A, Deep G, Katiyar S, Agarwal C, et al. Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft. Mol Cancer Ther. 2009;8:2366-74 pubmed publisher
    ..Together, these results suggest the potential use of silibinin against advanced human colorectal cancer. ..
  69. Siegal Gaskins D, Ash J, Crosson S. Model-based deconvolution of cell cycle time-series data reveals gene expression details at high resolution. PLoS Comput Biol. 2009;5:e1000460 pubmed publisher
  70. Landais I, Hiddingh S, McCarroll M, Yang C, Sun A, Turker M, et al. Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors. Mol Cancer. 2009;8:133 pubmed publisher
    ..These results suggest that monoketone analogs of curcumin are potent inhibitors of the FA pathway and constitute a promising new class of targeted anticancer compounds...
  71. Lukasiewicz K, Greenwood T, Negron V, Bruzek A, Salisbury J, Lingle W. Control of centrin stability by Aurora A. PLoS ONE. 2011;6:e21291 pubmed publisher
    ..Taken together, these results suggest that the stability of centrin is regulated in part by Aurora A, and that excess phosphorylated centrin may promote centrosome amplification in cancer. ..
  72. Li Z, Musich P, Serrano M, Dong Z, Zou Y. XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase. PLoS ONE. 2011;6:e28326 pubmed publisher
    ..In contrast, the nuclear import of XPA in G(1) or G(2) phase appears to be largely independent of DNA damage and p53. ..
  73. Serrano M, Li Z, Dangeti M, Musich P, Patrick S, Roginskaya M, et al. DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair. Oncogene. 2013;32:2452-62 pubmed publisher
    ..Furthermore, disruption of the release significantly compromised HR repair of DSBs. Our results reveal a mechanism for the crosstalk between HR repair and NHEJ through the co-regulation of p53-RPA interaction by DNA-PK, ATM and ATR. ..
  74. Masilamani T, Rintala Maki N, Wang K, Sutherland L. Downregulating activated epidermal growth factor receptor has no effect on RBM5 expression. Chin Med J (Engl). 2012;125:2378-81 pubmed
  75. Kapuria S, Karpac J, Biteau B, Hwangbo D, Jasper H. Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. PLoS Genet. 2012;8:e1003045 pubmed publisher
    ..Regulation of TSC/TOR activity by N signaling thus emerges as critical for maintenance and differentiation in somatic stem cell lineages. ..
  76. Chung S, McLean M, Rymond B. Yeast ortholog of the Drosophila crooked neck protein promotes spliceosome assembly through stable U4/U6.U5 snRNP addition. RNA. 1999;5:1042-54 pubmed
    ..Our results indicate that Clf1p acts as a scaffolding protein in spliceosome assembly and suggest that Clf1p may support the cross-intron bridge during the prespliceosome-to-spliceosome transition. ..
  77. Mansour A, McCarthy B, Schwander S, Chang V, Kotenko S, Donepudi S, et al. Genistein induces G2 arrest in malignant B cells by decreasing IL-10 secretion. Cell Cycle. 2004;3:1597-605 pubmed
    ..We conclude that genistein can sensitize malignant B cells to the action of other chemotherapeutic agents by modulating the cytokine profile and controlling cell cycle progression. ..
  78. Zhou H, Schulze R, Cox S, Saez C, Hu Z, Lutkenhaus J. Analysis of MinD mutations reveals residues required for MinE stimulation of the MinD ATPase and residues required for MinC interaction. J Bacteriol. 2005;187:629-38 pubmed
    ..This mutant provides evidence that dimerization of MinD is sufficient for MinD to bind the membrane and recruit its partners. ..
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