Genomes and Genes
Experts and Doctors on cell cycle proteins in United Kingdom
Locale: United Kingdom
Topic: cell cycle proteins
Publications164 found, 100 shown here
- Kaufmann I, White E, Azad A, Marguerat S, Bahler J, Proudfoot N. Transcriptional activation of the general amino acid permease gene per1 by the histone deacetylase Clr6 Is regulated by Oca2 kinase. Mol Cell Biol. 2010;30:3396-410 pubmed publisher..Loss of Cha4 or Ago1 causes aberrant induction of per1 under noninducing conditions, suggesting that these proteins are also involved in per1 regulation and hence in nitrogen utilization. ..
- Petermann E, Woodcock M, Helleday T. Chk1 promotes replication fork progression by controlling replication initiation. Proc Natl Acad Sci U S A. 2010;107:16090-5 pubmed publisher..Our data suggest that increased replication initiation leads to slow replication fork progression and that Chk1 promotes replication fork progression during normal S phase by controlling replication origin activity. ..
- Zarrinpashneh E, Poggioli T, Sarathchandra P, Lexow J, Monassier L, Terracciano C, et al. Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction. PLoS ONE. 2013;8:e80268 pubmed publisher..This study underscores the importance of SGK1 signalling in cardiac neo-angiogenesis and wound healing after an ischemic insult in vivo. ..
- Gilbert C, Green C, Lowndes N. Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. Mol Cell. 2001;8:129-36 pubmed..This complex then catalyzes activation of Rad53 by acting as a scaffold that brings Rad53 molecules into close proximity, facilitating Rad53 in trans autophosphorylation and subsequent release of activated Rad53. ..
- Dias S, Hogan C, Ochocka A, Meek D. Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover. FEBS Lett. 2009;583:3543-8 pubmed publisher..These data are consistent with the idea that deregulation of PLK1 during tumourigenesis may help suppress p53 function. ..
- Deshpande A, Ivanova I, Raykov V, Xue Y, Maringele L. Polymerase epsilon is required to maintain replicative senescence. Mol Cell Biol. 2011;31:1637-45 pubmed publisher..Every time resection and resynthesis switches, a fresh signal initiates, thus preventing checkpoint adaptation and ensuring the permanent character of senescence. ..
- Lavery D, Villaronga M, Walker M, Patel A, Belandia B, Bevan C. Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors. J Biol Chem. 2011;286:17796-808 pubmed publisher..This suggests that nuclear exclusion of HEY proteins may be an important step in the progression of prostate cancer. ..
- Tiengwe C, Marcello L, Farr H, Gadelha C, Burchmore R, Barry J, et al. Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture. PLoS ONE. 2012;7:e32674 pubmed publisher..brucei MCM subunits and show that this has the conventional eukaryotic heterohexameric structure, suggesting that divergence in the T. brucei replication machinery is limited to the earliest steps in origin licensing. ..
- Bazenet C, Mota M, Rubin L. The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death. Proc Natl Acad Sci U S A. 1998;95:3984-9 pubmed..Furthermore, Cdc42-induced death was prevented by coexpressing the c-Jun dominant negative FLAGDelta169. Thus, Cdc42 appears to function as an initiator of neuronal cell death by activating a transcriptional pathway regulated by c-Jun. ..
- Parmentier M, Woods D, Greig S, Phan P, Radovic A, Bryant P, et al. Rapsynoid/partner of inscuteable controls asymmetric division of larval neuroblasts in Drosophila. J Neurosci. 2000;20:RC84 pubmed..Our data show that Raps is a novel protein involved in the control of asymmetric divisions of neuroblasts. ..
- Pearce A, Wilde J, Doody G, Best D, Inoue O, Vigorito E, et al. Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C. Blood. 2002;100:3561-9 pubmed..The present study has provided evidence for a possible role of Vav1 but not Vav2 in the later stages of platelet aggregation. ..
- Weitzer S, Lehane C, Uhlmann F. A model for ATP hydrolysis-dependent binding of cohesin to DNA. Curr Biol. 2003;13:1930-40 pubmed..After DNA replication, two DNA strands may be trapped to promote sister chromatid cohesion. In anaphase, Scc1 cleavage opens the ring to release sister chromatids. ..
- Tör M, Gordon P, Cuzick A, Eulgem T, Sinapidou E, Mert Türk F, et al. Arabidopsis SGT1b is required for defense signaling conferred by several downy mildew resistance genes. Plant Cell. 2002;14:993-1003 pubmed..We discuss the role of AtSGT1b in disease resistance and its possible involvement in ubiquitin-mediated proteolysis in plants. ..
- Aldridge C, Møller S. The plastid division protein AtMinD1 is a Ca2+-ATPase stimulated by AtMinE1. J Biol Chem. 2005;280:31673-8 pubmed..We propose that correct intraplastidic AtMinD1 localization is dependent on AtMinE1-stimulated, Ca2+-dependent AtMinD1 ATP hydrolysis, ultimately ensuring precise Z-ring placement and symmetric plastid division. ..
- Robinson N, Bell S. Extrachromosomal element capture and the evolution of multiple replication origins in archaeal chromosomes. Proc Natl Acad Sci U S A. 2007;104:5806-11 pubmed
- Marshall R, Jolliffe N, Ceriotti A, Snowden C, Lord J, Frigerio L, et al. The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells. J Biol Chem. 2008;283:15869-77 pubmed publisher..Despite these differences, both proteins are similarly retro-translocated...
- Xu Z, Vagnarelli P, Ogawa H, Samejima K, Earnshaw W. Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis. J Biol Chem. 2010;285:40163-70 pubmed publisher..Our results also reveal that mitotic progression is accompanied by a requirement for progressively higher levels of Aurora B kinase activity. ..
- García P, Berlanga O, Watson R, Frampton J. Generation of a conditional allele of the B-myb gene. Genesis. 2005;43:189-95 pubmed..To demonstrate the efficiency and possible consequences of B-myb inactivation, we performed conditional deletion in cultured MEFs and observed decreased growth that correlated with aberrant nuclear DNA replication. ..
- Hodgson B, Calzada A, Labib K. Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phase. Mol Biol Cell. 2007;18:3894-902 pubmed..In contrast, Tof1 is critical for DNA replication forks to pause at diverse chromosomal sites where nonnucleosomal proteins bind very tightly to DNA, and this role is not shared with Mrc1...
- Taylor E, Copsey A, Hudson J, Vidot S, Lehmann A. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. Mol Cell Biol. 2008;28:1197-206 pubmed..Depletion also confers sensitivity to methyl methanesulfonate. Several of the components are modified by sumoylation and ubiquitination. ..
- Odell A, Hollstein M, Ponnambalam S, Walker J. A VE-cadherin-PAR3-?-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)? in endothelial cells. Mol Biol Cell. 2012;23:1783-96 pubmed publisher..Thus a VE-cadherin-PAR3-?-catenin adhesion complex regulates cPLA(2)? recruitment to the Golgi apparatus, with functional consequences for vascular physiology. ..
- al Khodairy F, Fotou E, Sheldrick K, Griffiths D, Lehmann A, Carr A. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. Mol Biol Cell. 1994;5:147-60 pubmed
- Wuarin J, Buck V, Nurse P, Millar J. Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication. Cell. 2002;111:419-31 pubmed..Thus, ORC bound mitotic Cyclin B/Cdc2 kinase imposes the dependency of S phase on an intervening mitosis but not the temporal licensing of replication origins between each S phase. ..
- Zhang W, Bergamaschi D, Jin B, Lu X. Posttranslational modifications of p27kip1 determine its binding specificity to different cyclins and cyclin-dependent kinases in vivo. Blood. 2005;105:3691-8 pubmed
- Anderson V, Prudden J, Prochnik S, Giddings T, Hardwick K. Novel sfi1 alleles uncover additional functions for Sfi1p in bipolar spindle assembly and function. Mol Biol Cell. 2007;18:2047-56 pubmed..3 microm apart. Importantly, these SPBs have completed duplication, but they are not separated, suggesting a possible defect in splitting of the bridge. We discuss possible roles for Sfi1p in this step in bipolar spindle assembly. ..
- Patel D, McCance D. Compromised spindle assembly checkpoint due to altered expression of Ubch10 and Cdc20 in human papillomavirus type 16 E6- and E7-expressing keratinocytes. J Virol. 2010;84:10956-64 pubmed publisher..Also, in E6/E7 cells with DNA damage, while Cdc20 is complexed with BubR1, indicating an active checkpoint, it is also present in complexes free of BubR1, presumably allowing APC/C activity and slippage through the checkpoint. ..
- Giesecke A, Stewart M. Novel binding of the mitotic regulator TPX2 (target protein for Xenopus kinesin-like protein 2) to importin-alpha. J Biol Chem. 2010;285:17628-35 pubmed publisher..The different way in which TPX2 binds to importin-alpha could account for much of the selectivity necessary during mitosis because this would reduce the competition for binding to importin-alpha from other NLS-containing proteins. ..
- Buttrick G, Meadows J, Lancaster T, Vanoosthuyse V, Shepperd L, Hoe K, et al. Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B. Mol Biol Cell. 2011;22:4486-502 pubmed publisher..These data suggest Nsk1 ensures accurate chromosome segregation by promoting the tethering of kinetochores to spindle poles during anaphase B...
- Blanco I, Kuchenbaecker K, Cuadras D, Wang X, Barrowdale D, de Garibay G, et al. Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers. PLoS ONE. 2015;10:e0120020 pubmed publisher..Together, the results of this study support the hypothesis of a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers. ..
- Sloss O, Topham C, Diez M, Taylor S. Mcl-1 dynamics influence mitotic slippage and death in mitosis. Oncotarget. 2016;7:5176-92 pubmed publisher..However, because mitotic degradation of Mcl-1 appears not to be under the control of an E3 ligase, we suggest that the notion of network crosstalk is used with caution. ..
- Hamoen L, Errington J. Polar targeting of DivIVA in Bacillus subtilis is not directly dependent on FtsZ or PBP 2B. J Bacteriol. 2003;185:693-7 pubmed..By using outgrowing spores, we show that DivIVA accumulates at the cell poles independent of the presence of FtsZ or PBP 2B. ..
- Errington J, Daniel R, Scheffers D. Cytokinesis in bacteria. Microbiol Mol Biol Rev. 2003;67:52-65, table of contents pubmed..The functions of most of these proteins are unclear with the exception of at least one penicillin-binding protein, which catalyzes a key step in cell wall synthesis in the division septum. ..
- Jenkinson E, Chong J. Minichromosome maintenance helicase activity is controlled by N- and C-terminal motifs and requires the ATPase domain helix-2 insert. Proc Natl Acad Sci U S A. 2006;103:7613-8 pubmed..Deletion of the helix-2 insert additionally resulted in the abrogation of DNA unwinding. Our results provide significant insight into the molecular mechanisms used by the MCM helicase to both regulate and execute DNA unwinding...
- Hollick J, Rigoreau L, Cano Soumillac C, Cockcroft X, Curtin N, Frigerio M, et al. Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the atax. J Med Chem. 2007;50:1958-72 pubmed..One of the most potent DNA-PK inhibitors identified, 2-(4-methoxyphenyl)-6-(morpholin-4-yl)pyran-4-one (16; DNA-PK; IC50=220 nM) effectively sensitized HeLa cells to the topoisomerase II inhibitor etoposide in vitro. ..
- Spender L, Cornish G, Rowland B, Kempkes B, Farrell P. Direct and indirect regulation of cytokine and cell cycle proteins by EBNA-2 during Epstein-Barr virus infection. J Virol. 2001;75:3537-46 pubmed..The results indicate that cytokines are an early target of EBNA-2 and that EBNA-2 can regulate cyclin D2 transcription in EBV-infected cells by mechanisms additional to the c-myc pathway. ..
- Goberdhan D, Wilson C. The functions of insulin signaling: size isn't everything, even in Drosophila. Differentiation. 2003;71:375-97 pubmed
- Seeliger M, Spichty M, Kelly S, Bycroft M, Freund S, Karplus M, et al. Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins. J Biol Chem. 2005;280:30448-59 pubmed..We propose that the dynamic properties of the beta-sheet and its modification upon ligand binding underlie the domain swapping ability and the adapter function of Cks proteins. ..
- Kitamura K, Katayama S, Dhut S, Sato M, Watanabe Y, Yamamoto M, et al. Phosphorylation of Mei2 and Ste11 by Pat1 kinase inhibits sexual differentiation via ubiquitin proteolysis and 14-3-3 protein in fission yeast. Dev Cell. 2001;1:389-99 pubmed..Overall, therefore, these results show that Pat1 coordinates concerted molecular mechanisms that govern the sexual differentiation developmental decision. ..
- Gunjan A, Verreault A. A Rad53 kinase-dependent surveillance mechanism that regulates histone protein levels in S. cerevisiae. Cell. 2003;115:537-49 pubmed..Our results argue that Rad53 contributes to genome stability independently of Mec1 by preventing the damaging effects of excess histones both during normal cell cycle progression and in response to DNA damage. ..
- Magyar Z, De Veylder L, Atanassova A, Bako L, Inze D, Bogre L. The role of the Arabidopsis E2FB transcription factor in regulating auxin-dependent cell division. Plant Cell. 2005;17:2527-41 pubmed..We conclude that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA. ..
- Stewart M, Krause S, McGhie J, Gray J. Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. Eukaryot Cell. 2007;6:262-70 pubmed..We conclude that Mpt5p is required for normal replicative and chronological life spans and that the CWI pathway is a key and direct downstream target of this PUF protein. ..
- Herr A, Molnar A, Jones A, Baulcombe D. Defective RNA processing enhances RNA silencing and influences flowering of Arabidopsis. Proc Natl Acad Sci U S A. 2006;103:14994-5001 pubmed..According to this proposal, in the absence of these ESP proteins, these RNAs have aberrant 3' termini. The aberrant RNAs would enter the RNA silencing pathways because they are converted into dsRNA by RNA-dependent RNA polymerases. ..
- Adam J, Deans B, Thacker J. A role for Xrcc2 in the early stages of mouse development. DNA Repair (Amst). 2007;6:224-34 pubmed
- Dewitte W, Riou Khamlichi C, Scofield S, Healy J, Jacqmard A, Kilby N, et al. Altered cell cycle distribution, hyperplasia, and inhibited differentiation in Arabidopsis caused by the D-type cyclin CYCD3. Plant Cell. 2003;15:79-92 pubmed
- Chen J, Stoeber K, Kingsbury S, Ozanne S, Williams G, Hales C. Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. J Biol Chem. 2004;279:49439-46 pubmed..Our data suggest that loss of proliferative capacity in oxidatively stressed cells is a multistep process regulated by time-dependent molecular events that may play differential roles in induction and maintenance of cellular senescence. ..
- Bencokova Z, Kaufmann M, Pires I, Lecane P, Giaccia A, Hammond E. ATM activation and signaling under hypoxic conditions. Mol Cell Biol. 2009;29:526-37 pubmed publisher..Our findings clearly demonstrate that there are alternate mechanisms for activating ATM that are both stress-specific and independent of the presence of DNA breaks. ..
- Nasmyth K, Haering C. Cohesin: its roles and mechanisms. Annu Rev Genet. 2009;43:525-58 pubmed publisher..Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits. ..
- Autret S, Errington J. Dynamic proteins in bacteria. Dev Cell. 2001;1:10-1 pubmed..The MinCDE system regulates the position of the division plane in rod-shaped bacteria. New results from Escherichia coli provide insight into how this operates by showing that MinE stimulates the ATPase activity of MinD...
- Ahnesorg P, Jackson S. The non-homologous end-joining protein Nej1p is a target of the DNA damage checkpoint. DNA Repair (Amst). 2007;6:190-201 pubmed
- Clift D, Bizzari F, Marston A. Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase. Genes Dev. 2009;23:766-80 pubmed publisher..We propose that Cdc55 is a separase inhibitor that acts downstream from Shugoshin under conditions where sister chromatids are not under tension. ..
- Roberts C, Sutherland H, Farmer H, Kimber W, Halford S, Carey A, et al. Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality. Mol Cell Biol. 2002;22:2318-28 pubmed
- Tournier S, Gachet Y, Buck V, Hyams J, Millar J. Disruption of astral microtubule contact with the cell cortex activates a Bub1, Bub3, and Mad3-dependent checkpoint in fission yeast. Mol Biol Cell. 2004;15:3345-56 pubmed..We propose that this checkpoint ensures spindles are properly oriented before anaphase takes place. ..
- Regnier V, Vagnarelli P, Fukagawa T, Zerjal T, Burns E, Trouche D, et al. CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1. Mol Cell Biol. 2005;25:3967-81 pubmed..Our data thus point to a specific role for CENP-A in assembly of kinetochores competent in the maintenance of mitotic checkpoint signaling. ..
- Oberoi J, Richards M, Crumpler S, Brown N, Blagg J, Bayliss R. Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR). J Biol Chem. 2010;285:39348-58 pubmed publisher..The PBZ motif of CHFR recognizes two adenine-containing subunits of PAR and the phosphate backbone that connects them. More generally, PBZ motifs may recognize different numbers of PAR subunits as required to carry out their functions. ..
- Masuda H, Fong C, Ohtsuki C, Haraguchi T, Hiraoka Y. Spatiotemporal regulations of Wee1 at the G2/M transition. Mol Biol Cell. 2011;22:555-69 pubmed publisher..Then Wee1 disappears from the SPB during spindle assembly. We propose that regulation of Wee1 localization around the SPB during the G2/M transition is important for proper mitotic entry and progression...
- Lin Y, Prendergast J, Grey F. The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication. PLoS Pathog. 2017;13:e1006329 pubmed publisher..Finally, we show that NMS-873, a small molecule inhibitor of VCP, is a potent HCMV antiviral with potential as a novel host targeting therapeutic for HCMV infection. ..
- Shieh J, Wilkinson M, Millar J. The Win1 mitotic regulator is a component of the fission yeast stress-activated Sty1 MAPK pathway. Mol Biol Cell. 1998;9:311-22 pubmed..Our results suggest that the stress-activated Sty1 MAPK integrates information from multiple signaling pathways. ..
- Giet R, Glover D. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J Cell Biol. 2001;152:669-82 pubmed..This is accompanied by a failure to correctly localize the Pavarotti kinesin-like protein, essential for this process. We discuss these conserved functions of Aurora B kinase in chromosome transmission and cytokinesis. ..
- Hearle N, Damato B, Humphreys J, Wixey J, Green H, Stone J, et al. Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma. Invest Ophthalmol Vis Sci. 2003;44:458-62 pubmed..It is likely that mutations in other genes contribute to an inherited predisposition to uveal melanoma. ..
- Riballo E, Kühne M, Rief N, Doherty A, Smith G, Recio M, et al. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell. 2004;16:715-24 pubmed..The significant radiosensitivity of Artemis-deficient cells demonstrates the importance of this component of DSB repair to survival. ..
- Ge X, Jackson D, Blow J. Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev. 2007;21:3331-41 pubmed..We propose that checkpoint kinase activity can preferentially suppress initiation within inactive replicon clusters, thereby directing new initiation events toward active clusters that are experiencing replication problems. ..
- Xhemalce B, Kouzarides T. A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly. Genes Dev. 2010;24:647-52 pubmed publisher..Consistent with structural data, H3K4ac specifically reduces Chp1/Clr4 affinity to H3K9me. We propose that H3K4ac mediates a chromodomain switch from Chp1/Clr4 to Swi6/Chp2 to allow heterochromatin reassembly. ..
- Venkei Z, Przewloka M, Glover D. Drosophila Mis12 complex acts as a single functional unit essential for anaphase chromosome movement and a robust spindle assembly checkpoint. Genetics. 2011;187:131-40 pubmed publisher..Importantly our results indicate that core structural elements of the inner plate of the kinetochore have a greater contribution to faithful chromosome segregation in anaphase than in earlier stages of mitosis. ..
- Whitehall S, Stacey P, Dawson K, Jones N. Cell cycle-regulated transcription in fission yeast: Cdc10-Res protein interactions during the cell cycle and domains required for regulated transcription. Mol Biol Cell. 1999;10:3705-15 pubmed
- Stiff T, O Driscoll M, Rief N, Iwabuchi K, Lobrich M, Jeggo P. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 2004;64:2390-6 pubmed..However, by phosphorylating H2AX, DNA-PK can contribute to the presence of the damage response proteins MDC1 and 53BP1 at the site of the DSB. ..
- Jones N, Katan M. Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1. Mol Cell Biol. 2007;27:5790-805 pubmed..As a component of this complex, PLCgamma1 is also involved in the activation of Cdc42 and Rac1. ..
- Polesello C, Tapon N. Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch. Curr Biol. 2007;17:1864-70 pubmed..The PCP members of the SWH network are not involved in this process, indicating that signaling upstream of Hpo varies according to developmental context. ..
- Sanz L, Dewitte W, Forzani C, Patell F, Nieuwland J, Wen B, et al. The Arabidopsis D-type cyclin CYCD2;1 and the inhibitor ICK2/KRP2 modulate auxin-induced lateral root formation. Plant Cell. 2011;23:641-60 pubmed publisher..We propose that ICK2/KRP2 restrains root ramification by maintaining CYCD2;1 inactive and that this modulates pericycle responses to auxin fluctuations. ..
- Niwa H, Ewens C, Tsang C, Yeung H, Zhang X, Freemont P. The role of the N-domain in the ATPase activity of the mammalian AAA ATPase p97/VCP. J Biol Chem. 2012;287:8561-70 pubmed publisher..This leads us to propose a model where the N-domain adopts either of two conformations: a flexible conformation compatible with ATP hydrolysis or a coplanar conformation that is inactive. ..
- Smith G, Cary R, Lakin N, Hann B, Teo S, Chen D, et al. Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM. Proc Natl Acad Sci U S A. 1999;96:11134-9 pubmed
- Shikama N, Chan H, Krstic Demonacos M, Smith L, Lee C, Cairns W, et al. Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators. Mol Cell Biol. 2000;20:8933-43 pubmed..These results argue that NAP is a functionally important component of the p300 coactivator complex and suggest that NAP may serve as a point of integration between transcriptional coactivators and chromatin. ..
- Reynolds L, Smyth L, Norton T, Freshney N, Downward J, Kioussis D, et al. Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. J Exp Med. 2002;195:1103-14 pubmed..We show that this latter function is independent of PI3K. ..
- Taschner M, Harreman M, Teng Y, Gill H, Anindya R, Maslen S, et al. A role for checkpoint kinase-dependent Rad26 phosphorylation in transcription-coupled DNA repair in Saccharomyces cerevisiae. Mol Cell Biol. 2010;30:436-46 pubmed publisher..These findings establish a direct role for Mec1 kinase in transcription-coupled repair, at least partly via phosphorylation of Rad26, the main transcription-repair coupling factor. ..
- Chahal H, Trivellin G, Leontiou C, Alband N, Fowkes R, Tahir A, et al. Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway. J Clin Endocrinol Metab. 2012;97:E1411-20 pubmed publisher..001). These results suggest that AIP may play a role in the mechanism of action of somatostatin analogs via ZAC1 in sporadic somatotroph tumors and may explain their lack of effectiveness in patients with AIP mutations. ..
- Pettitt A, Sherrington P, Stewart G, Cawley J, Taylor A, Stankovic T. p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation. Blood. 2001;98:814-22 pubmed..This is the first study to provide a direct demonstration that p53 dysfunction can arise in a sporadic tumor by a mechanism that does not involve TP53 mutation. (Blood. 2001;98:814-822) ..
- Simon M, Vanes L, Geahlen R, Tybulewicz V. Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells. J Biol Chem. 2005;280:4510-7 pubmed..Finally we show that Tyr317 functions as a negative regulatory site and that its mutation can partially compensate for the loss of both Tyr342 and Tyr346. ..
- Abraham S, Lawrence T, Kleiman A, Warden P, Medghalchi M, Tuckermann J, et al. Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. J Exp Med. 2006;203:1883-9 pubmed..Therefore, the expression of DUSP1 is required for the inhibition of proinflammatory signaling pathways by Dex in mouse macrophages. Furthermore, DUSP1 contributes to the antiinflammatory effects of Dex in vitro and in vivo. ..
- Olcina M, Lecane P, Hammond E. Targeting hypoxic cells through the DNA damage response. Clin Cancer Res. 2010;16:5624-9 pubmed publisher..In this situation, phosphorylation of H2AX has been shown to be required for proliferation and angiogenesis and is, therefore, an attractive potential therapeutic target. ..
- He E, Kapuy O, Oliveira R, Uhlmann F, Tyson J, Novak B. System-level feedbacks make the anaphase switch irreversible. Proc Natl Acad Sci U S A. 2011;108:10016-21 pubmed publisher..These and other puzzles associated with the mitotic checkpoint are addressed by a proposed molecular mechanism, which involves two positive feedback loops that create a bistable response of the checkpoint to chromosomal tension. ..
- Lamarche Vane N, Hall A. CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac. J Biol Chem. 1998;273:29172-7 pubmed..Thus, CdGAP is a novel GAP that is likely to participate in Cdc42- and Rac-induced signaling pathways leading to actin reorganization. ..
- Geymonat M, Spanos A, Smith S, Wheatley E, Rittinger K, Johnston L, et al. Control of mitotic exit in budding yeast. In vitro regulation of Tem1 GTPase by Bub2 and Bfa1. J Biol Chem. 2002;277:28439-45 pubmed..Therefore, we propose that Bfa1 acts both as an adaptor to connect Bub2 and Tem1 and as an allosteric effector that facilitates this interaction. ..
- Rouse J, Jackson S. Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell. 2002;9:857-69 pubmed..Recruitment of Lcd1p to these lesions is independent of Mec1p and Rad9p/Rad24p. Thus, recruitment of Mec1p to DNA lesions by Lcd1p is crucial for the DNA damage response. ..
- Caspari T, Dahlen M, Kanter Smoler G, Lindsay H, Hofmann K, Papadimitriou K, et al. Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9. Mol Cell Biol. 2000;20:1254-62 pubmed..However, two-hybrid interaction, in vitro association and in vivo overexpression experiments suggest a transient interaction between Rad1 and Rad17. ..
- Anderson L, Henderson C, Adachi Y. Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage. Mol Cell Biol. 2001;21:1719-29 pubmed..These results suggest a role for 53BP1 in the DNA damage response and/or checkpoint control which may involve signaling of damage to p53. ..
- Robinson N, Dionne I, Lundgren M, Marsh V, Bernander R, Bell S. Identification of two origins of replication in the single chromosome of the archaeon Sulfolobus solfataricus. Cell. 2004;116:25-38 pubmed..These data, in conjunction with an analysis of the levels of the three Orc1/Cdc6 proteins in different growth phases and cell cycle stages, lead us to propose a model for the roles for these proteins in modulating origin activity...