Genomes and Genes
Experts and Doctors on cell cycle proteins in Germany
Topic: cell cycle proteins
Publications300 found, 100 shown here
- Sheynzon P, Korf H. Targeted deletions of Mel1a and Mel1b melatonin receptors affect pCREB levels in lactotroph and pars intermedia cells of mice. Neurosci Lett. 2006;407:48-52 pubmed..Our results indicate that Mel1a and Mel1b melatonin receptors are involved in the control of the activity state of lactotroph and pars intermedia cells of mice. ..
- Kleinschmidt M, Wagner T, Liedtke D, Spahr S, Samans B, Gaubatz S. lin9 is required for mitosis and cell survival during early zebrafish development. J Biol Chem. 2009;284:13119-27 pubmed publisher..Our data establish LIN9 as an essential regulator of mitosis in vertebrate development. ..
- Tarakhovsky A, Turner M, Schaal S, Mee P, Duddy L, Rajewsky K, et al. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature. 1995;374:467-70 pubmed..We also suggest a direct link between the low proliferative response of Vav-deficient B and T cells and the reduced number of these cells in peripheral lymphoid organs of chimaeric mice. ..
- Meindl A, Dry K, Herrmann K, Manson F, Ciccodicola A, Edgar A, et al. A gene (RPGR) with homology to the RCC1 guanine nucleotide exchange factor is mutated in X-linked retinitis pigmentosa (RP3). Nat Genet. 1996;13:35-42 pubmed..The two intragenic deletions, two nonsense and three missense mutations within conserved domains provide evidence that RPGR (retinitis pigmentosa GTPase regulator) is the RP3 gene. ..
- Liebetrau W, Budde A, Savoia A, Grummt F, Hoehn H. p53 activates Fanconi anemia group C gene expression. Hum Mol Genet. 1997;6:277-83 pubmed..We suggest that the p53 binding site contributes to, but may not be an absolute prerequisite for p53-directed transcriptional activation. We conclude that the FAC gene can be added to the list of genes that interact with p53. ..
- Mösch H, Kübler E, Krappmann S, Fink G, Braus G. Crosstalk between the Ras2p-controlled mitogen-activated protein kinase and cAMP pathways during invasive growth of Saccharomyces cerevisiae. Mol Biol Cell. 1999;10:1325-35 pubmed
- Konrad L, Aumuller G. Calcyclin is differentially expressed in rat testicular cells. Biochim Biophys Acta. 1999;1489:440-4 pubmed..Our findings point to a paracrine regulation of calcyclin expression in testicular peritubular fibroblasts which seems to be related to tubular growth. ..
- Braun S, Matuschewski K, Rape M, Thoms S, Jentsch S. Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates. EMBO J. 2002;21:615-21 pubmed..We propose that CDC48(UFD1/NPL4) functions as a segregase that liberates ubiquitylated proteins from non-modified partners. ..
- Distel L, Neubauer S, Varon R, Holter W, Grabenbauer G. Fatal toxicity following radio- and chemotherapy of medulloblastoma in a child with unrecognized Nijmegen breakage syndrome. Med Pediatr Oncol. 2003;41:44-8 pubmed..Several hereditary disorders including immunodeficiency (ID) syndromes or repair disorders, Ataxia Telangiectasia (AT), and Nijmegen breakage syndrome (NBS) were associated with an elevated risk for severe treatment related toxicity...
- Nguyen M, Beck J, Lue H, Fünfzig H, Kleemann R, Koolwijk P, et al. A 16-residue peptide fragment of macrophage migration inhibitory factor, MIF-(50-65), exhibits redox activity and has MIF-like biological functions. J Biol Chem. 2003;278:33654-71 pubmed..We conclude that CXXC and sequence 50-65 are critical for the activities of MIF. MIF-(50-65) is a surprisingly short sequence with MIF-like functions that could be an excellent molecular template for MIF therapeutics. ..
- Preisinger C, Körner R, Wind M, Lehmann W, Kopajtich R, Barr F. Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling. EMBO J. 2005;24:753-65 pubmed..These findings identify a Plk1-dependent signalling mechanism potentially linking Golgi structure and cell cycle control, but suggest that this may not be a cell cycle checkpoint in the classical sense. ..
- Skawran B, Schubert S, Dechend F, Vervoorts J, Nayernia K, Luscher B, et al. Characterization of a human TSPY promoter. Mol Cell Biochem. 2005;276:159-67 pubmed..Our findings strongly suggest that testis-specific expression of human TSPY is mediated by Sox proteins. ..
- Habedanck R, Stierhof Y, Wilkinson C, Nigg E. The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol. 2005;7:1140-6 pubmed..These findings provide an attractive explanation for the crucial function of Plk4 in cell proliferation and have implications for the role of Polo kinases in tumorigenesis. ..
- Maier M, Geiger E, Henrich D, Ebrahimi R, Wutzler S, Lehnert M, et al. Apoptosis differs in dendritic cell subsets early after severe trauma. Hum Immunol. 2009;70:803-8 pubmed publisher..However, the overall response of DCs early after trauma is characterized by an increased activation of antiapoptotic mediators that might indicate a compensatory life-prolonging reaction. ..
- Reichert N, Wurster S, Ulrich T, Schmitt K, Hauser S, Probst L, et al. Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice, and for tumor suppression. Mol Cell Biol. 2010;30:2896-908 pubmed publisher..Together these experiments provide the first direct genetic evidence for the role of LIN9 in development and mitotic gene regulation and they suggest that it may function as a haploinsufficient tumor suppressor. ..
- Mogavero S, Tavanti A, Senesi S, Rogers P, Morschh user J. Differential requirement of the transcription factor Mcm1 for activation of the Candida albicans multidrug efflux pump MDR1 by its regulators Mrr1 and Cap1. Antimicrob Agents Chemother. 2011;55:2061-6 pubmed publisher..Our findings provide more detailed insight into the molecular mechanisms of drug resistance in this important human fungal pathogen...
- Artus C, Glacial F, Ganeshamoorthy K, Ziegler N, Godet M, Guilbert T, et al. The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells. J Cereb Blood Flow Metab. 2014;34:433-40 pubmed publisher..In conclusion, this study suggests that the Wnt/Par/aPKC PCP pathway, in addition to the Wnt/?-catenin canonical pathway, is a key regulator of the BBB. ..
- Ueberberg S, Tannapfel A, Schenker P, Viebahn R, Uhl W, Schneider S, et al. Differential expression of cell-cycle regulators in human beta-cells derived from insulinoma tissue. Metabolism. 2016;65:736-46 pubmed publisher..Targeting such differentially regulated cell-cycle proteins may evolve as a future strategy to enhance beta-cell regeneration. ..
- Gulbins E, Schlottmann K, Brenner B, Lang F, Coggeshall K. Molecular analysis of Ras activation by tyrosine phosphorylated Vav. Biochem Biophys Res Commun. 1995;217:876-85 pubmed..To study molecular characteristics of this Vav-Ras interaction, we used several Ras mutants and demonstrate that Vav activity towards Ras depends on the integrity of the same or similar domains as Ras activation by SDC 25 or CDC 25. ..
- Sauer G, Körner R, Hanisch A, Ries A, Nigg E, Sillje H. Proteome analysis of the human mitotic spindle. Mol Cell Proteomics. 2005;4:35-43 pubmed..This study illustrates the strength of a proteomic approach for the analysis of isolated human spindles and identifies several novel spindle components for future functional studies. ..
- Behrend L, Mohr A, Dick T, Zwacka R. Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells. Mol Cell Biol. 2005;25:7758-69 pubmed..This novel mitochondrially mediated mechanism of tumor suppression might enable strategies that allow reactivation of cellular aging in tumor cells. ..
- Schuberth C, Buchberger A. Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation. Nat Cell Biol. 2005;7:999-1006 pubmed..Lack of Ubx2 causes defects in ERAD that are exacerbated under stress conditions. These findings are consistent with a model in which Ubx2 coordinates the assembly of a highly efficient ERAD machinery at the ER membrane. ..
- Wang Z, Spittau B, Behrendt M, Peters B, Krieglstein K. Human TIEG2/KLF11 induces oligodendroglial cell death by downregulation of Bcl-XL expression. J Neural Transm (Vienna). 2007;114:867-75 pubmed..These data suggest that TIEG2 serves as a downstream mediator of TGF-beta, bridging TGF-beta-dependent signaling to the intracellular pathway of apoptosis. ..
- Srinivasan V, Netz D, Webert H, Mascarenhas J, Pierik A, Michel H, et al. Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis. Structure. 2007;15:1246-57 pubmed..We show that Ciao1 can functionally replace Cia1 and support cytosolic Fe/S protein biogenesis. Hence, our structural and biochemical studies indicate the conservation of Cia1 function in eukaryotes. ..
- Graser S, Stierhof Y, Lavoie S, Gassner O, Lamla S, Le Clech M, et al. Cep164, a novel centriole appendage protein required for primary cilium formation. J Cell Biol. 2007;179:321-30 pubmed..Moreover, the localizations of Cep164 and ninein/Cep170 were mutually independent during interphase. These data implicate distal appendages in PC formation and identify Cep164 as an excellent marker for these structures...
- Iacopetti P, Michelini M, Stuckmann I, Oback B, Aaku Saraste E, Huttner W. Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division. Proc Natl Acad Sci U S A. 1999;96:4639-44 pubmed..Using TIS21 as a marker, we find that the switch from proliferative to neuron-generating divisions is initiated in single NE cells rather than in synchronized neighboring cells. ..
- Herrmann U, Soppa J. Cell cycle-dependent expression of an essential SMC-like protein and dynamic chromosome localization in the archaeon Halobacterium salinarum. Mol Microbiol. 2002;46:395-409 pubmed..The Sph1 concentration is elevated when segregation of the new chromosomes is nearly complete; therefore, it is proposed to play a role in a late step of replication, e.g. DNA repair, similar to eukaryotic Rad18 proteins...
- Al Sarraj A, Day R, Thiel G. Specificity of transcriptional regulation by the zinc finger transcription factors Sp1, Sp3, and Egr-1. J Cell Biochem. 2005;94:153-67 pubmed..This does not exclude the existence of composite Sp1/Sp3/Egr-1 binding sites, where competition for a common DNA-binding site occurs. ..
- Fürst R, Brueckl C, Kuebler W, Zahler S, Krotz F, Gorlach A, et al. Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2-activation. Circ Res. 2005;96:43-53 pubmed..In summary, our work provides insights into the mechanisms by which ANP induces MKP-1 and shows that ANP is a novel endogenous activator of endothelial Rac1 and Nox/Nox2. ..
- Ruppenthal S, Noll A, Götz C, Montenarh M. Interference between p53 and cdc25C in cell cycle regulation. Int J Oncol. 2007;31:345-52 pubmed..Thus, our data show that p53 like other binding partners of cdc25C, regulates entry into mitosis by binding to cdc25C. ..
- Kleylein Sohn J, Westendorf J, Le Clech M, Habedanck R, Stierhof Y, Nigg E. Plk4-induced centriole biogenesis in human cells. Dev Cell. 2007;13:190-202 pubmed..Collectively, these data afford a comprehensive view of the assembly pathway underlying centriole biogenesis in human cells...
- Helmstaedt K, Schwier E, Christmann M, Nahlik K, Westermann M, Harting R, et al. Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site. Mol Biol Cell. 2011;22:153-64 pubmed publisher..We propose a two-step Cand1 binding to unneddylated cullins which initiates at the adaptor binding site and subsequently blocks the neddylation site after CSN has left...
- Köcher S, Rieckmann T, Rohaly G, Mansour W, Dikomey E, Dornreiter I, et al. Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase. Nucleic Acids Res. 2012;40:8336-47 pubmed..Together, these results provide new insight into the role of ATM for initiation and completion of HR during S- and G2-phase. The DSB repair defect during S-phase significantly contributes to the radiosensitivity of AT cells. ..
- Minnen A, BÃ¼rmann F, Wilhelm L, Anchimiuk A, Diebold Durand M, Gruber S. Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA. Cell Rep. 2016;14:2003-16 pubmed publisher..Our findings define an intermediate state in the process of chromosome organization by Smc. ..
- Liakopoulos D, Doenges G, Matuschewski K, Jentsch S. A novel protein modification pathway related to the ubiquitin system. EMBO J. 1998;17:2208-14 pubmed..This suggests that the RUB1 conjugation pathway is functionally affiliated to the ubiquitin-proteasome system and may play a regulatory role. ..
- Irniger S, Baumer M, Braus G. Glucose and ras activity influence the ubiquitin ligases APC/C and SCF in Saccharomyces cerevisiae. Genetics. 2000;154:1509-21 pubmed..We conclude that glucose and Ras proteins influence the APC/C and the SCF complex in an opposite manner. These ubiquitin ligases might represent novel targets for modulating cell division in response to growth conditions. ..
- Dork T, Bendix R, Bremer M, Rades D, Klöpper K, Nicke M, et al. Spectrum of ATM gene mutations in a hospital-based series of unselected breast cancer patients. Cancer Res. 2001;61:7608-15 pubmed..Screening for frequent A-T mutations such as the 1066-6-->G splice site substitution can be effective to prospectively identify A-T heterozygotes in an unselected cancer patient population. ..
- Geisen C, Moroy T. The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein. J Biol Chem. 2002;277:39909-18 pubmed..Rather, we propose that cyclin E harbors other functions, independent of Cdk2 activation and p27(Kip1) binding, that contribute significantly to its oncogenic activity. ..
- Bauer I, Al Sarraj J, Vinson C, Larsen R, Thiel G. Interleukin-1beta and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor alpha in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-activated protein kinases. J Cell Biochem. 2007;100:242-55 pubmed
- Buck A, Buchholz M, Wagner M, Adler G, Gress T, Ellenrieder V. The tumor suppressor KLF11 mediates a novel mechanism in transforming growth factor beta-induced growth inhibition that is inactivated in pancreatic cancer. Mol Cancer Res. 2006;4:861-72 pubmed
- Sari F, Heinrich M, Meyer W, Braus G, Irniger S. The C-terminal region of the meiosis-specific protein kinase Ime2 mediates protein instability and is required for normal spore formation in budding yeast. J Mol Biol. 2008;378:31-43 pubmed publisher..We conclude that downregulation of Ime2 kinase activity mediated by the C-terminal domain is required for the efficient production of normal four-spore asci. Our data suggest a role for Ime2 in spore number control in S. cerevisiae. ..
- Said H, Stein S, Hagemann C, Polat B, Staab A, Anacker J, et al. Oxygen-dependent regulation of NDRG1 in human glioblastoma cells in vitro and in vivo. Oncol Rep. 2009;21:237-46 pubmed
- Steinhauser I, Langer K, Strebhardt K, Spänkuch B. Uptake of plasmid-loaded nanoparticles in breast cancer cells and effect on Plk1 expression. J Drug Target. 2009;17:627-37 pubmed publisher..Taken together, HSA nanoparticles represent promising tools to deliver expression plasmids for shRNAs into target cells and should be further evaluated with regard to a therapeutic application of RNA interference in cancer therapy. ..
- Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung W, et al. Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet. 2012;8:e1002728 pubmed publisher..These data clearly establish the three HEY bHLH factors as highly redundant transcriptional repressors in vitro and in vivo, which explains the combinatorial action observed in different tissues with overlapping expression. ..
- Roth N, Klimesch J, Dukowic Schulze S, Pacher M, Mannuss A, Puchta H. The requirement for recombination factors differs considerably between different pathways of homologous double-strand break repair in somatic plant cells. Plant J. 2012;72:781-90 pubmed publisher..Both SSA and SDSA were affected only weakly when the SMC6B protein, implicated in sister chromatid recombination, was absent, indicating that SSA and SDSA are in most cases intrachromatid recombination reactions. ..
- Baumer M, Kunzler M, Steigemann P, Braus G, Irniger S. Yeast Ran-binding protein Yrb1p is required for efficient proteolysis of cell cycle regulatory proteins Pds1p and Sic1p. J Biol Chem. 2000;275:38929-37 pubmed..We suggest that Ubs1p may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity. ..
- Tedford K, Nitschke L, Girkontaite I, Charlesworth A, Chan G, Sakk V, et al. Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nat Immunol. 2001;2:548-55 pubmed..These findings establish a role for Vav-2 in BCR calcium signaling and reveal that the Vav family of GEFs is critical to B cell development and function. ..
- Von Gall C, Garabette M, Kell C, Frenzel S, Dehghani F, Schumm Draeger P, et al. Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin. Nat Neurosci. 2002;5:234-8 pubmed..Our findings expose a mechanism by which two convergent signals interact within a temporal dimension to establish high-amplitude, precise and robust cycles of gene expression. ..
- Biermann E, Baack M, Kreitz S, Knippers R. Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle. Eur J Biochem. 2002;269:1040-6 pubmed..The data suggest a surprisingly dynamic behaviour of Cdc6p in the HeLa cell cycle. ..
- Gruber J, Harborth J, Schnabel J, Weber K, Hatzfeld M. The mitotic-spindle-associated protein astrin is essential for progression through mitosis. J Cell Sci. 2002;115:4053-9 pubmed..Cells depleted of astrin were normal during interphase but were unable to progress through mitosis and finally ended in apoptotic cell death. Possible functions of astrin in mitotic spindle organization are discussed. ..
- Yuan J, Eckerdt F, Bereiter Hahn J, Kurunci Csacsko E, Kaufmann M, Strebhardt K. Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. Oncogene. 2002;21:8282-92 pubmed..Still, multiple serine mutations are required to prevent nuclear translocation completely indicating that orchestrated phosphorylation within the CRS triggers rapid import of cyclin B1. ..
- Reuter T, Medhurst A, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, et al. Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. Exp Cell Res. 2003;289:211-21 pubmed..Taken together, our data strongly support the hypothesis that FA proteins are functionally involved in several complex cellular pathways including transcription regulation, cell signaling, oxidative metabolism, and cellular transport. ..
- Zueger M, Urani A, Chourbaji S, Zacher C, Lipp H, Albrecht U, et al. mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning. J Neural Transm (Vienna). 2006;113:347-56 pubmed..None of these learning types were affected by the mutations, suggesting that mPer1 and mPer2 do not play a major role in the regulation of hippocampus-dependent learning and memory. ..
- Haller F, Gunawan B, von Heydebreck A, Schwager S, Schulten H, Wolf Salgó J, et al. Prognostic role of E2F1 and members of the CDKN2A network in gastrointestinal stromal tumors. Clin Cancer Res. 2005;11:6589-97 pubmed..Our findings implicate differential regulation schemes of the CDKN2A tumor suppressor pathway converging to up-regulation of E2F1 as the critical link to increased cell proliferation and adverse prognosis of GISTs. ..
- Grelle G, Kostka S, Otto A, Kersten B, Genser K, Müller E, et al. Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Mol Cell Proteomics. 2006;5:234-44 pubmed
- Santamaria A, Neef R, Eberspächer U, Eis K, Husemann M, Mumberg D, et al. Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis. Mol Biol Cell. 2007;18:4024-36 pubmed..Finally, we show that Plk1 activity is essential for cleavage furrow formation and ingression, leading to successful cytokinesis. ..
- Popov N, Herold S, Llamazares M, Schülein C, Eilers M. Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. Cell Cycle. 2007;6:2327-31 pubmed..Our data extend previous observations that link Myc function to the cellular response to DNA damage. ..
- Jeyaprakash A, Klein U, Lindner D, Ebert J, Nigg E, Conti E. Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell. 2007;131:271-85 pubmed..Association of the core "passenger" proteins creates a single structural unit, whose composite molecular surface presents conserved residues essential for central spindle and midbody localization. ..
- Witte G, Hartung S, Büttner K, Hopfner K. Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates. Mol Cell. 2008;30:167-78 pubmed publisher..Identification of the diadenylate cyclase domain in other eubacterial and archaeal proteins implies a more general role for c-di-AMP in prokaryotes. ..
- Schmidt T, Kleylein Sohn J, Westendorf J, Le Clech M, Lavoie S, Stierhof Y, et al. Control of centriole length by CPAP and CP110. Curr Biol. 2009;19:1005-11 pubmed publisher..We thus propose that CPAP and CP110 play antagonistic roles in determining the extent of tubulin addition during centriole elongation, thereby controlling the length of newly formed centrioles...
- Schneider G, Henrich A, Greiner G, Wolf V, Lovas A, Wieczorek M, et al. Cross talk between stimulated NF-kappaB and the tumor suppressor p53. Oncogene. 2010;29:2795-806 pubmed publisher..Our observations suggest explanations for the outstanding question why p53 mutations rather than p53 deletions arise in tumors of various origins. ..
- Hovest M, Krieg T, Herrmann G. Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence. Exp Dermatol. 2011;20:883-9 pubmed publisher..In conclusion, Chk1 and FANCD2 function downstream of ATR in a non-redundant manner for the establishment and maintenance of psoralen photoactivation-induced senescence. ..
- Hüls D, Storchova Z, Niessing D. Post-translational modifications regulate assembly of early spindle orientation complex in yeast. J Biol Chem. 2012;287:16238-45 pubmed publisher..The observed effects of these modifications allow us to propose a novel regulatory framework for the assembly and disassembly of the early spindle orientation complex. ..
- Lu K, den Brave F, Jentsch S. Receptor oligomerization guides pathway choice between proteasomal and autophagic degradation. Nat Cell Biol. 2017;19:732-739 pubmed publisher..Our work thus suggests that proteasomal degradation and selective autophagy are two branches of an adaptive protein quality control pathway, which uses substrate ubiquitylation as a shared degradation signal. ..
- Gagrica S, Hauser S, Kolfschoten I, Osterloh L, Agami R, Gaubatz S. Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein. EMBO J. 2004;23:4627-38 pubmed..These data suggest that hLin-9 has tumor-suppressing activities and that the ability of hLin-9 to inhibit transformation is mediated through its association with pRB. ..
- Gruneberg U, Glotzer M, Gartner A, Nigg E. The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo. J Cell Biol. 2002;158:901-14 pubmed..These findings identify the CDC14 phosphatase as an important regulator of central spindle formation and cytokinesis in a metazoan organism. ..
- Guarguaglini G, Duncan P, Stierhof Y, Holmström T, Duensing S, Nigg E. The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. Mol Biol Cell. 2005;16:1095-107 pubmed..We show that Cep170 labeling can be used to discriminate bona fide centriole overduplication from centriole amplification that results from aborted cell division. ..
- Franz A, Orth M, Pirson P, Sonneville R, Blow J, Gartner A, et al. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Mol Cell. 2011;44:85-96 pubmed publisher..Moreover, our data confirmed a similar regulation in Xenopus egg extracts, emphasizing a conserved coordination of licensing and elongation events during eukaryotic DNA replication by CDC-48/p97. ..
- Burkhart R, Schulte D, Hu D, Musahl C, Göhring F, Knippers R. Interactions of human nuclear proteins P1Mcm3 and P1Cdc46. Eur J Biochem. 1995;228:431-8 pubmed..Our data imply that the active form of an Mcm protein is not a monomer, but a protein complex that includes an Mcm3/Cdc46 dimer. DNA polymerase alpha is not a component of this complex. ..
- Horstmann S, Ferrari S, Klempnauer K. An alternatively spliced isoform of B-Myb is a transcriptional inhibitor. Oncogene. 2000;19:5428-34 pubmed..The results presented here demonstrate that B-myb encodes both an activator and an inhibitor of transcription and, thus, reveal an additional level of regulation of B-Myb activity beside the known cyclin dependent mechanisms. ..
- Klein U, Nigg E, Gruneberg U. Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. Mol Biol Cell. 2006;17:2547-58 pubmed..Our findings thus establish a functional module within the CPC that assembles on the N terminus of INCENP and controls centromere recruitment. ..
- Schubert V, Zelkowski M, Klemme S, Houben A. Similar Sister Chromatid Arrangement in Mono- and Holocentric Plant Chromosomes. Cytogenet Genome Res. 2016;149:218-225 pubmed..Based on these results, models of the sister chromatid arrangement in mono- and holocentric plant chromosomes are presented. ..
- Schuster N, Bender H, Philippi A, Subramaniam S, Strelau J, Wang Z, et al. TGF-beta induces cell death in the oligodendroglial cell line OLI-neu. Glia. 2002;40:95-108 pubmed
- Rehtanz M, Schmidt H, Warthorst U, Steger G. Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription. Mol Cell Biol. 2004;24:2153-68 pubmed..These results suggest that the binding of sequence-specific DNA binding proteins to hNAP-1 may be an important step contributing to the activation of transcription. ..
- Kubsch S, Graulich E, Knop J, Steinbrink K. Suppressor activity of anergic T cells induced by IL-10-treated human dendritic cells: association with IL-2- and CTLA-4-dependent G1 arrest of the cell cycle regulated by p27Kip1. Eur J Immunol. 2003;33:1988-97 pubmed..Our data show that regulatory function of anergic CD4+ suppressor T cells is associated with an arrest in the G1 phase of the cell cycle mediated by increased levels of the IL-2- and CTLA-4-dependent cdk inhibitor p27Kip1. ..
- Kramps C, Strieder V, Sapetschnig A, Suske G, Lutz W. E2F and Sp1/Sp3 Synergize but are not sufficient to activate the MYCN gene in neuroblastomas. J Biol Chem. 2004;279:5110-7 pubmed
- Rosenberger G, Gal A, Kutsche K. AlphaPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. J Biol Chem. 2005;280:6879-89 pubmed..Whereas alphaPIX GEF activity contributes to enhanced formation of cellular protrusions, the GEF-independent association with calpain 4 leads to induction of a yet unknown signaling cascade resulting in cell spreading. ..
- Gambichler T, Shtern M, Rotterdam S, Bechara F, Stucker M, Altmeyer P, et al. Minichromosome maintenance proteins are useful adjuncts to differentiate between benign and malignant melanocytic skin lesions. J Am Acad Dermatol. 2009;60:808-13 pubmed publisher..MCM3 as well as MCM4 are differentially expressed in BN, DN, and SSM. Hence, immunolabeling of MCM3 and MCM4 proteins appears to be a promising additive tool for distinguishing benign from malignant melanocytic skin lesions. ..
- Zink L, Delbarre E, Eberl H, Keilhauer E, Bönisch C, Pünzeler S, et al. H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements. Nucleic Acids Res. 2017;45:5691-5706 pubmed publisher..These data demonstrate that H3.Y's unique amino acids allow a functional distinction between HIRA and DAXX binding and its consequent deposition into open chromatin. ..
- Rumpf S, Jentsch S. Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone. Mol Cell. 2006;21:261-9 pubmed..We propose that the balance between the distinct substrate-processing cofactors may determine whether a substrate is multiubiquitylated and routed to the proteasome for degradation or deubiquitylated and/or released for other purposes. ..
- Siehler S, Schrauder M, Gerischer U, Cantor S, Marra G, Wiesmuller L. Human MutL-complexes monitor homologous recombination independently of mismatch repair. DNA Repair (Amst). 2009;8:242-52 pubmed publisher..Our data indicate a protective role of hMutL-complexes in a process which may lead to detrimental genome rearrangements, in a manner which does not depend on mismatch repair. ..
- Yuan J, Sanhaji M, Kramer A, Reindl W, Hofmann M, Kreis N, et al. Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo. Am J Pathol. 2011;179:2091-9 pubmed publisher..The data highlight that targeting the PBD by Poloxin is a powerful approach for selectively inhibiting Plk1 function in vitro and in vivo. ..
- Faul T, Staib C, Nanda I, Schmid M, Grummt F. Identification and characterization of mouse homologue to yeast Cdc7 protein and chromosomal localization of the cognate mouse gene Cdc7l. Chromosoma. 1999;108:26-31 pubmed..Conservation of structures among members of the Cdc7-related proteins suggests that these proteins play a key role in the regulation of DNA replication during the cell cycle in all eukaryotes. ..
- Hematulin A, Sagan D, Eckardt Schupp F, Moertl S. NBS1 is required for IGF-1 induced cellular proliferation through the Ras/Raf/MEK/ERK cascade. Cell Signal. 2008;20:2276-85 pubmed publisher..In conclusion, our findings provide strong evidence that NBS1 has a functional role in IGF-1 signaling for the promotion of cell proliferation via the Ras/Raf/MEK/ERK cascade. ..
- Scheiter M, Lau U, van Ham M, Bulitta B, Gröbe L, Garritsen H, et al. Proteome analysis of distinct developmental stages of human natural killer (NK) cells. Mol Cell Proteomics. 2013;12:1099-114 pubmed publisher..Upon activation of human primary NK cells, both proteins are recruited into the immune synapse (NKIS), where they colocalize with myosin IIa. ..
- Ladenburger E, Fackelmayer F, Hameister H, Knippers R. MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12-->q13. Cytogenet Cell Genet. 1997;77:268-70 pubmed..The genomic DNA fragment was used for hybridization to human metaphase chromosome spreads. The cytogenetic map location of the two closely adjacent genes was determined to be 8q12-->q13. ..
- Disch S, Anastasiou E, Sharma V, Laux T, Fletcher J, Lenhard M. The E3 ubiquitin ligase BIG BROTHER controls arabidopsis organ size in a dosage-dependent manner. Curr Biol. 2006;16:272-9 pubmed..Our data indicate that plants limit the duration of organ growth and ultimately organ size by actively degrading critical growth stimulators. ..
- Iden S, Rehder D, August B, Suzuki A, Wolburg Buchholz K, Wolburg H, et al. A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep. 2006;7:1239-46 pubmed..They also point to a direct role of a cadherin in the regulation of cell polarity in vertebrates. ..
- Berges C, Fuchs D, Opelz G, Daniel V, Naujokat C. Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms. Mol Immunol. 2009;46:2892-901 pubmed publisher..Thus, helenalin can be defined as a new immunosuppressive compound suited for the treatment of deregulated and unwanted T cell-mediated immune responses. ..