Experts and Doctors on cdc2 protein kinase in Canada


Locale: Canada
Topic: cdc2 protein kinase

Top Publications

  1. Clegg N, Whitehead I, Williams J, Spiegelman G, Grigliatti T. A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster. Genome. 1993;36:676-85 pubmed
    ..The phenotypes of our mutants are consistent with a role for Cdc2 in cell proliferation; however, we did not observe any perturbation of the endoreduplication cycle associated with the acquisition of polyteny. ..
  2. Santaguida M, Ding Q, Bérubé G, Truscott M, Whyte P, Nepveu A. Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2). J Biol Chem. 2001;276:45780-90 pubmed
    ..In summary, our results suggest that the phosphorylation of CDP/Cux by cyclin A-Cdk1 contributes to down-modulate CDP/Cux activity as cells progress into the G(2) phase of the cell cycle. ..
  3. Proteau A, Blier S, Albert A, Lavoie S, Traish A, Vincent M. The multifunctional nuclear protein p54nrb is multiphosphorylated in mitosis and interacts with the mitotic regulator Pin1. J Mol Biol. 2005;346:1163-72 pubmed
    ..Our results also showed that Pin1 binding was favored when at least two of the three threonine residues were phosphorylated, suggesting a regulation mechanism based on multisite phosphorylation. ..
  4. O Reilly P, Wagner S, Franks D, Cailliau K, Browaeys E, Dissous C, et al. The Ste20-like kinase SLK is required for cell cycle progression through G2. J Biol Chem. 2005;280:42383-90 pubmed
    ..Overexpression of active SLK resulted in ectopic spindle assembly and the induction of cell cycle re-entry of Xenopus oocytes, suggesting that SLK is required for progression through G2 upstream of H1 kinase activation. ..
  5. Kennedy E, Dysart M, Lianga N, Williams E, Pilon S, Doré C, et al. Redundant Regulation of Cdk1 Tyrosine Dephosphorylation in Saccharomyces cerevisiae. Genetics. 2016;202:903-10 pubmed publisher
  6. Wang P, Larouche M, Normandin K, Kachaner D, Mehsen H, Emery G, et al. Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle. Cell Cycle. 2016;15:528-39 pubmed publisher
    ..Our results indicate that the cyclic changes in Gwl localization at mitotic entry and exit are directly regulated by the antagonistic cyclin B-Cdk1 and PP2A-Tws enzymes. ..