Experts and Doctors on cation transport proteins in Israel


Locale: Israel
Topic: cation transport proteins

Top Publications

  1. Ohana E, Segal D, Palty R, Ton That D, Moran A, Sensi S, et al. A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells. J Biol Chem. 2004;279:4278-84 pubmed
    ..Such mechanism is likely to play an important role, not only in generating the transmembrane zinc gradients, but also in protecting cells from the potentially toxic effects of permeation of this ion. ..
  2. Elgazar V, Razanov V, Stoltenberg M, Hershfinkel M, Huleihel M, Nitzan Y, et al. Zinc-regulating proteins, ZnT-1, and metallothionein I/II are present in different cell populations in the mouse testis. J Histochem Cytochem. 2005;53:905-12 pubmed
    ..The specific expression of ZnT-1 in the Sertoli cells, moreover, is consistent with their role in maintaining a nurturing, closely regulated environment for spermatogenesis. ..
  3. Levy S, Kafri M, Carmi M, Barkai N. The competitive advantage of a dual-transporter system. Science. 2011;334:1408-12 pubmed publisher
    ..Dual-transporter systems appear to prolong preparation for starvation and to facilitate subsequent recovery, which may optimize sensing of nutrient depletion by integrating internal and external information about nutrient availability. ..
  4. Levin D, DiPaolo R, Brinster C, Revilleza M, Boyd L, Teyton L, et al. Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis. Eur J Immunol. 2008;38:3339-53 pubmed publisher
    ..Thus, the autoimmune potential of these TCR in their respective Tg lines is strongly influenced by the availability of the peptide epitope, rather than by differential avidity for their respective MHC/p complexes. ..
  5. Ohana E, Hoch E, Keasar C, Kambe T, Yifrach O, Hershfinkel M, et al. Identification of the Zn2+ binding site and mode of operation of a mammalian Zn2+ transporter. J Biol Chem. 2009;284:17677-86 pubmed publisher
    ..These findings indicate, for the first time, that Zn2+ transport mediated by a mammalian ZnT is catalyzed by H+/Zn2+ exchange and identify the zinc binding site of ZnT proteins essential for zinc transport. ..
  6. Mor M, Beharier O, Levy S, Kahn J, Dror S, Blumenthal D, et al. ZnT-1 enhances the activity and surface expression of T-type calcium channels through activation of Ras-ERK signaling. Am J Physiol Cell Physiol. 2012;303:C192-203 pubmed publisher
    ..1 and CaV3.2 through activation of Ras-ERK signaling. The augmentation of CaV3.1 currents by Ras-ERK activation is associated with enhanced trafficking of the channel to the plasma membrane. ..
  7. Schushan M, Barkan Y, Haliloglu T, Ben Tal N. C(alpha)-trace model of the transmembrane domain of human copper transporter 1, motion and functional implications. Proc Natl Acad Sci U S A. 2010;107:10908-13 pubmed publisher
    ..We suggest a molecular mechanism of copper transport in which this motif serves both as a gate and as a selectivity filter. We also suggest residues that are responsible for pH activation. ..
  8. Beharier O, Etzion Y, Levi S, Mor M, Mor M, Dror S, et al. The involvement of ZnT-1, a new modulator of cardiac L-type calcium channels, in [corrected] atrial tachycardia remodeling. [corrected]. Ann N Y Acad Sci. 2010;1188:87-95 pubmed publisher
    ..Finally, in a pilot study, ZnT-1 expression was found to be augmented in the atria of AF patients. These findings position ZnT-1 as a probable missing link in the mechanism underlying atrial tachycardia remodeling. ..
  9. Erez O, Kahana C. Screening for modulators of spermine tolerance identifies Sky1, the SR protein kinase of Saccharomyces cerevisiae, as a regulator of polyamine transport and ion homeostasis. Mol Cell Biol. 2001;21:175-84 pubmed
    ..While deletion or overexpression of SKY1 did not significantly affect Pma1p activity, the ability of overexpressed Sky1p, Ptk1p, and Ptk2p to increase sensitivity to LiCl depends on the integrity of PPZ1 but not of ENA1. ..

More Information


  1. Flannick J, Thorleifsson G, Beer N, Jacobs S, Grarup N, Burtt N, et al. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat Genet. 2014;46:357-63 pubmed publisher
    ..In contrast, loss-of-function mutations in humans provide strong evidence that SLC30A8 haploinsufficiency protects against T2D, suggesting ZnT8 inhibition as a therapeutic strategy in T2D prevention. ..
  2. Carey L, van Dijk D, Sloot P, Kaandorp J, Segal E. Promoter sequence determines the relationship between expression level and noise. PLoS Biol. 2013;11:e1001528 pubmed publisher
    ..Taken together, we show that the precise amount by which noise changes with expression is specific to the regulatory mechanism of transcription and translation that acts at each gene. ..
  3. Hoch E, Lin W, Chai J, Hershfinkel M, Fu D, Sekler I. Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity. Proc Natl Acad Sci U S A. 2012;109:7202-7 pubmed publisher
  4. Beharier O, Dror S, Levy S, Kahn J, Mor M, Etzion S, et al. ZnT-1 protects HL-1 cells from simulated ischemia-reperfusion through activation of Ras-ERK signaling. J Mol Med (Berl). 2012;90:127-38 pubmed publisher
    ..However, following reperfusion ZnT-1 levels were found to be decreased. Our findings indicate that ZnT-1 may have important role in the ischemic myocardium through its ability to interact with Raf-1 kinase. ..
  5. Karol N, Brodski C, Bibi Y, Kaisman T, Forberg M, Hershfinkel M, et al. Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc. J Cell Physiol. 2010;224:567-74 pubmed publisher
    ..Our findings support the conclusion that ZHP expression is regulated by crosstalk between synaptic and intracellular pools of Zn(2+). ..
  6. Kaisman Elbaz T, Sekler I, Fishman D, Karol N, Forberg M, Kahn N, et al. Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules. J Cell Physiol. 2009;220:222-9 pubmed publisher
    ..Taken together, our results indicate that Zn(2+) and Cd(2+) influx induce expression and secretion of clusterin, thereby linking metal homeostasis and germ cell fate...
  7. Etzion Y, Ganiel A, Beharier O, Shalev A, Novack V, Volvich L, et al. Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study. J Cardiovasc Electrophysiol. 2008;19:157-64 pubmed
    ..62, 0.31; P = 0.002, P = 0.04, respectively). This pilot study provides evidence for increased ZnT-1 expression in the atria of patients with atrial fibrillation. ..
  8. Beharier O, Etzion Y, Katz A, Friedman H, Tenbosh N, Zacharish S, et al. Crosstalk between L-type calcium channels and ZnT-1, a new player in rate-dependent cardiac electrical remodeling. Cell Calcium. 2007;42:71-82 pubmed
  9. Tako E, Ferket P, Uni Z. Changes in chicken intestinal zinc exporter mRNA expression and small intestinal functionality following intra-amniotic zinc-methionine administration. J Nutr Biochem. 2005;16:339-46 pubmed
    ..These results suggest that ZnMet administration into prenatal intestine via injection into the amniotic fluid enhances intestinal development and improves its functionality. ..
  10. Gruper Y, Bar J, Bacharach E, Ehrlich R. Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells. J Cell Physiol. 2005;204:901-12 pubmed
    ..Based on previous and these data we suggest that the level of intracellular iron may regulate both TfR expression (on the post-transcriptional and the post-translational levels) and TfR trafficking/transcytosis in polarized cells. ..
  11. Erez O, Kahana C. Deletions of SKY1 or PTK2 in the Saccharomyces cerevisiae trk1Deltatrk2Delta mutant cells exert dual effect on ion homeostasis. Biochem Biophys Res Commun. 2002;295:1142-9 pubmed
    ..A model that integrates these results to explain the mechanism of ion transport across the plasma membrane is proposed. ..
  12. Kalinsky H, Funes A, Zeldin A, Pel Or Y, Korostishevsky M, Gershoni Baruch R, et al. Novel ATP7B mutations causing Wilson disease in several Israeli ethnic groups. Hum Mutat. 1998;11:145-51 pubmed
    ..Identification of all WD mutations will undoubtedly increase our understanding of the normal function of ATP7B as well as lead to more accurate prognosis and genetic counseling. ..
  13. Perez Y, Shorer Z, Liani Leibson K, Chabosseau P, Kadir R, Volodarsky M, et al. SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome. Brain. 2017;140:928-939 pubmed publisher