Experts and Doctors on cathepsins in Sweden


Locale: Sweden
Topic: cathepsins

Top Publications

  1. Lennartsson A, Garwicz D, Lindmark A, Gullberg U. The proximal promoter of the human cathepsin G gene conferring myeloid-specific expression includes C/EBP, c-myb and PU.1 binding sites. Gene. 2005;356:193-202 pubmed
    ..Separate mutations of the putative C/EBP binding site, c-myb-binding site or the GC-rich element resulted in a dramatically reduced transcriptional activity in both cell lines, suggesting cooperation between corresponding trans-factors. ..
  2. Johansson A, Claesson R, Belibasakis G, Makoveichuk E, Hänström L, Olivecrona G, et al. Protease inhibitors, the responsible components for the serum-dependent enhancement of Actinobacillus actinomycetemcomitans leukotoxicity. Eur J Oral Sci. 2001;109:335-41 pubmed
    ..The degradation is caused by enzymes from degranulated PMNL triggered by leukotoxin. ..
  3. Henningsson F, Wolters P, Chapman H, Caughey G, Pejler G. Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Biol Chem. 2003;384:1527-31 pubmed
    ..The present study thus indicates novel roles for cathepsins C and S in regulating the levels of stored proteases in the mast cell secretory granules. ..
  4. Hu Y, Ek Rylander B, Karlström E, Wendel M, Andersson G. Osteoclast size heterogeneity in rat long bones is associated with differences in adhesive ligand specificity. Exp Cell Res. 2008;314:638-50 pubmed
    ..The small osteoclast adhering to PT and TH may represent either an immature, less functional precursor to the large osteoclast or alternatively constitute a distinct osteoclast population with a specific role in bone. ..
  5. Stroikin Y, Dalen H, Lööf S, Terman A. Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material. Eur J Cell Biol. 2004;83:583-90 pubmed
    ..The data also suggest that specific components of lysosomes, such as membranes and proteins, may be direct sources of lipofuscin. ..
  6. Westin U, Fryksmark U, Polling A, Ohlsson K. Localisation of secretory leucocyte proteinase inhibitor mRNA in nasal mucosa. Acta Otolaryngol. 1994;114:199-202 pubmed
    ..This, together with the high concentration of SLPI in nasal secretions, confirms the hypothesis of a local production of SLPI in the mucous membranes. ..
  7. Hall A, Hakansson K, Mason R, Grubb A, Abrahamson M. Structural basis for the biological specificity of cystatin C. Identification of leucine 9 in the N-terminal binding region as a selectivity-conferring residue in the inhibition of mammalian cysteine peptidases. J Biol Chem. 1995;270:5115-21 pubmed
  8. Tryselius Y, Hultmark D. Cysteine proteinase 1 (CP1), a cathepsin L-like enzyme expressed in the Drosophila melanogaster haemocyte cell line mbn-2. Insect Mol Biol. 1997;6:173-81 pubmed
    ..The data presented suggest a role for cysteine proteinase in immune functions in insects. It is likely to participate in the degradation of internalized material in phagocytic cells. ..
  9. Aveskogh M, Lützelschwab C, Huang M, Hellman L. Characterization of cDNA clones encoding mouse proteinase 3 (myeloblastine) and cathepsin G. Immunogenetics. 1997;46:181-91 pubmed
    ..All amino acid positions of major importance for the cleavage site selection have also been fully conserved between mouse and human proteinase 3 and a few minor changes have occurred between mouse and human cathepsin G. ..

More Information


  1. Mandic A, Viktorsson K, Strandberg L, Heiden T, Hansson J, Linder S, et al. Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis. Mol Cell Biol. 2002;22:3003-13 pubmed
    ..In summary, calpain-mediated Bid cleavage is important in drug-induced apoptosis, and cisplatin induces at least two separate apoptotic signaling pathways resulting in Bid cleavage and Bak modulation, respectively. ..
  2. Ueno T, Linder S, Na C, Rice W, Johansson J, Weaver T. Processing of pulmonary surfactant protein B by napsin and cathepsin H. J Biol Chem. 2004;279:16178-84 pubmed
    ..These results suggest that napsin, cathepsin H, and at least one other enzyme are involved in maturation of the biologically active SP-B peptide. ..
  3. Alvarez Fernandez M, Liang Y, Abrahamson M, Su X. Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile. J Biol Chem. 2005;280:18221-8 pubmed
  4. Ljusberg J, Wang Y, Lång P, Norgård M, Dodds R, Hultenby K, et al. Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclasts. J Biol Chem. 2005;280:28370-81 pubmed
    ..Moreover, cathepsin K, but not cathepsin L, co-localized with TRAP in osteoclast-resorptive compartments, supporting a role for cathepsin K in the extracellular processing of monomeric TRAP in the resorption lacuna. ..
  5. Ljunggren A, Redzynia I, Alvarez Fernandez M, Abrahamson M, Mort J, Krupa J, et al. Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease. J Mol Biol. 2007;371:137-53 pubmed publisher
    ..This information will aid in the development of synthetic inhibitors for use as potential drugs for the treatment of Chagas disease...
  6. Hollberg K, Marsell R, Norgård M, Larsson T, Jonsson K, Andersson G. Osteoclast polarization is not required for degradation of bone matrix in rachitic FGF23 transgenic mice. Bone. 2008;42:1111-21 pubmed publisher
    ..The data collectively provide evidence that osteoclasts, despite absence of ruffled borders, effectively participate in the degradation of hypomineralized bone matrix in rachitic FGF23 tg mice. ..