Genomes and Genes
Experts and Doctors on carrier proteins in United Kingdom
Locale: United Kingdom
Topic: carrier proteins
Publications332 found, 100 shown here
- Chamberlain L, Roth D, Morgan A, Burgoyne R. Distinct effects of alpha-SNAP, 14-3-3 proteins, and calmodulin on priming and triggering of regulated exocytosis. J Cell Biol. 1995;130:1063-70 pubmed
- Freeth J, Silva C, Whatmore A, Clayton P. Activation of the signal transducers and activators of transcription signaling pathway by growth hormone (GH) in skin fibroblasts from normal and GH binding protein-positive Laron Syndrome children. Endocrinology. 1998;139:20-8 pubmed..These fibroblast cultures therefore provide unique models with which to further our understanding of the mechanisms of human GH signaling. ..
- Sönnichsen B, Lowe M, Levine T, Jämsä E, Dirac Svejstrup B, Warren G. A role for giantin in docking COPI vesicles to Golgi membranes. J Cell Biol. 1998;140:1013-21 pubmed..Together these results suggest that COPI vesicles are docked by giantin on the COPI vesicles and GM130 on Golgi membranes with p115 providing a bridge...
- Lamarche Vane N, Hall A. CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac. J Biol Chem. 1998;273:29172-7 pubmed..Thus, CdGAP is a novel GAP that is likely to participate in Cdc42- and Rac-induced signaling pathways leading to actin reorganization. ..
- Fullwood Y, dos Santos M, Hsuan J. Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta. J Biol Chem. 1999;274:31553-8 pubmed
- Werner A, Kinne R. Evolution of the Na-P(i) cotransport systems. Am J Physiol Regul Integr Comp Physiol. 2001;280:R301-12 pubmed..We hypothesize that the original NaPi-IIb-related gene was duplicated early in vertebrate development. The appearance of NaPi-IIa correlates with the development of the mammalian nephron...
- Spurway T, Dalley J, High S, Bulleid N. Early events in glycosylphosphatidylinositol anchor addition. substrate proteins associate with the transamidase subunit gpi8p. J Biol Chem. 2001;276:15975-82 pubmed..The ability of the transamidase to recognize and associate with GPI anchor signal sequences provides an explanation for the retention of GPI-anchored protein within the ER in the absence of GPI anchor addition. ..
- Seeger M, Hartmann Petersen R, Wilkinson C, Wallace M, Samejima I, Taylor M, et al. Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteins. J Biol Chem. 2003;278:16791-6 pubmed..The putative role of Pus1 as a factor involved in allocation of ubiquitinylated substrates for the proteasome is discussed. ..
- Hutchings N, Clarkson N, Chalkley R, Barclay A, Brown M. Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. J Biol Chem. 2003;278:22396-403 pubmed..These adaptor proteins are important in T cell signaling consistent with a role for CD2 in regulating pathways initiated by CMS/CIN85 and CAPZ. ..
- Hudson D, Ohta S, Freisinger T, MacIsaac F, Sennels L, Alves F, et al. Molecular and genetic analysis of condensin function in vertebrate cells. Mol Biol Cell. 2008;19:3070-9 pubmed publisher..Thus, despite their similar molecular organization, condensin and cohesin exhibit fundamental differences in their structure and function. ..
- Cuello F, Bardswell S, Haworth R, Ehler E, Sadayappan S, Kentish J, et al. Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation. J Biol Chem. 2011;286:5300-10 pubmed publisher..We conclude that Ser(282) in cMyBP-C is a novel cardiac RSK substrate and its selective phosphorylation appears to regulate cardiac myofilament function...
- Modun B, Williams P. The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3-phosphate dehydrogenase. Infect Immun. 1999;67:1086-92 pubmed..These studies demonstrate that the staphylococcal transferrin receptor protein, Tpn, is a multifunctional cell wall GAPDH. ..
- Baldwin T, Handford M, Yuseff M, Orellana A, Dupree P. Identification and characterization of GONST1, a golgi-localized GDP-mannose transporter in Arabidopsis. Plant Cell. 2001;13:2283-95 pubmed..The identification of a Golgi-localized nucleotide sugar transporter from plants will allow the study of the importance of this class of proteins in the synthesis of plant cell surface components such as cell wall polysaccharides. ..
- Holland J, Langford P, Towner K, Williams P. Evidence for in vivo expression of transferrin-binding proteins in Haemophilus influenzae type b. Infect Immun. 1992;60:2986-91 pubmed..These findings indicate that the H. influenzae type b transferrin receptor is expressed during experimental animal and human infections. ..
- Rodriguez M, Dargemont C, Hay R. SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting. J Biol Chem. 2001;276:12654-9 pubmed..Thus, protein substrates must be targeted to the nucleus to undergo SUMO-1 conjugation. ..
- Jaju R, Fidler C, Haas O, Strickson A, Watkins F, Clark K, et al. A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia. Blood. 2001;98:1264-7 pubmed..The reciprocal transcript, NSD1-NUP98, was also detected by reverse transcriptase--polymerase chain reaction. This is the first report in which the novel gene NSD1 has been implicated in human malignancy. (Blood. 2001;98:1264-1267) ..
- Hope R, Murphy D, McLauchlan J. The domains required to direct core proteins of hepatitis C virus and GB virus-B to lipid droplets share common features with plant oleosin proteins. J Biol Chem. 2002;277:4261-70 pubmed..These studies identify common features in disparate proteins that are required for lipid droplet localization. ..
- Dyer J, Wood I, Palejwala A, Ellis A, Shirazi Beechey S. Expression of monosaccharide transporters in intestine of diabetic humans. Am J Physiol Gastrointest Liver Physiol. 2002;282:G241-8 pubmed
- Wang P, Gilmore A, Streuli C. Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by integrins. J Biol Chem. 2004;279:41280-5 pubmed..Cell lines selected over many passages in culture have lost much of their sensitivity to anoikis signals arising from an altered cellular microenvironment and may undergo apoptosis through acquired mechanisms. ..
- Lawrence J, Mundell S, Yun H, Kelly E, Venkateswarlu K. Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization. Mol Pharmacol. 2005;67:1822-8 pubmed..Thus, ARF6 GAPs, such as centaurin alpha(1), are likely to play a crucial role in GPCR trafficking by modulating the activity of ARF6. ..
- Dietrich I, MacIntyre A, McMonagle E, Price A, James L, McEwan W, et al. Potent lentiviral restriction by a synthetic feline TRIM5 cyclophilin A fusion. J Virol. 2010;84:8980-5 pubmed publisher..FeTRIMCyp and FIV infections of the cat offer a unique opportunity to evaluate TRIMCyp-based approaches to genetic therapy for HIV infection and the treatment of AIDS...
- Oliver C, Khaled W, Frend H, Nichols J, Watson C. The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev. 2012;26:1086-97 pubmed publisher..These data suggest that the luminal alveolar compartment of the mammary gland is comprised of a number of distinct cell populations that, although interdependant, exhibit considerable cell fate plasticity. ..
- Nicholson B, McGivan J. Induction of high affinity glutamate transport activity by amino acid deprivation in renal epithelial cells does not involve an increase in the amount of transporter protein. J Biol Chem. 1996;271:12159-64 pubmed..It is proposed that low glutamate levels lead to the induction of a putative protein that activates the EAAC1 transporter. A model illustrating such a mechanism is described. ..
- Golby P, Kelly D, Guest J, Andrews S. Topological analysis of DcuA, an anaerobic C4-dicarboxylate transporter of Escherichia coli. J Bacteriol. 1998;180:4821-7 pubmed..The topological model obtained for DcuA can be applied to DcuA homologues in other bacteria as well as to DcuB. Overproduction of DcuA to 15% of inner-membrane protein was obtained with the lacUV5-promoter-based plasmid, pYZ4. ..
- Stanley N, Palmer T, Berks B. The twin arginine consensus motif of Tat signal peptides is involved in Sec-independent protein targeting in Escherichia coli. J Biol Chem. 2000;275:11591-6 pubmed..Tat signal peptides characteristically have positively charged carboxyl-terminal regions. However, changing the sign of this charge does not affect export of SufI. ..
- Elton D, Simpson Holley M, Archer K, Medcalf L, Hallam R, McCauley J, et al. Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathway. J Virol. 2001;75:408-19 pubmed..Consistent with this, NP bound CRM1 in vitro. Overall, these data raise the possibility that RNP export is mediated by a direct interaction between NP and the cellular CRM1 export pathway. ..
- Dart C, Leyland M. Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. J Biol Chem. 2001;276:20499-505 pubmed..Together, these findings suggest that AKAP79 associates directly with the Kir2.1 ion channel and may serve to anchor kinase enzymes in close proximity to key channel phosphorylation sites. ..
- Tümpel S, Sanz Ezquerro J, Isaac A, Eblaghie M, Dobson J, Tickle C. Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development. Dev Biol. 2002;250:251-62 pubmed..Anterior Tbx3 expression appears to be related to the width of limb bud, which determines digit number. ..
- Kashiwagi M, Enghild J, Gendron C, Hughes C, Caterson B, Itoh Y, et al. Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. J Biol Chem. 2004;279:10109-19 pubmed..Finding of ADAMTS-4 in the interleukin-1alpha-treated porcine articular cartilage primarily as a 46-kDa form suggests that it exhibits a broader substrate spectrum in the tissue than originally considered. ..
- Roy A, Levine T. Multiple pools of phosphatidylinositol 4-phosphate detected using the pleckstrin homology domain of Osh2p. J Biol Chem. 2004;279:44683-9 pubmed..For example, in cells with excess PtdIns(4)P caused by inactivation of the phosphatase Sac1p, PH(Osh2) indicates that PtdIns(4)P accumulates on the plasma membrane, whereas other Golgi-targeted PH domains fail to detect this change. ..
- Hirst J, Miller S, Taylor M, von Mollard G, Robinson M. EpsinR is an adaptor for the SNARE protein Vti1b. Mol Biol Cell. 2004;15:5593-602 pubmed..These findings provide in vivo evidence that epsinR is an adaptor for vti1b, and they also show that CCV isolation can be used as an assay for adaptor function. ..
- Suzuki S, Henderson P. The hydantoin transport protein from Microbacterium liquefaciens. J Bacteriol. 2006;188:3329-36 pubmed..The His-tagged hydantoin transport protein was located in the inner membrane fraction, from which it was solubilized and purified and its identity was authenticated. ..
- Huertas P, Jackson S. Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J Biol Chem. 2009;284:9558-65 pubmed publisher..These results suggest that CDK-mediated control of resection in human cells operates by mechanisms similar to those recently established in yeast. ..
- Yates L, Lumb C, Brahme N, Zalyte R, Bird L, De Colibus L, et al. Structural and functional characterization of the kindlin-1 pleckstrin homology domain. J Biol Chem. 2012;287:43246-61 pubmed publisher..We suggest the physiological ligand of the kindlin-1 PH domain is most likely not an inositol phosphate but another phosphorylated species. ..
- Roversi P, Ryffel B, Togbe D, Maillet I, Teixeira M, Ahmat N, et al. Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury. J Biol Chem. 2013;288:18789-802 pubmed publisher..The findings suggest that dual inhibition of C5 and LTB4 may be useful for treatment of human immune complex-dependent diseases. ..
- McElwee M, Beilstein F, Labetoulle M, Rixon F, Pasdeloup D. Dystonin/BPAG1 promotes plus-end-directed transport of herpes simplex virus 1 capsids on microtubules during entry. J Virol. 2013;87:11008-18 pubmed publisher..We conclude that, during entry of HSV-1, dystonin has a specific role in plus-ended transport of capsids from the centrosome to the nucleus. ..
- Cooper C, Wrigglesworth J, Nicholls P. The mechanism of potassium movement across the liposomal membrane. Biochem Biophys Res Commun. 1990;173:1008-12 pubmed..M., Cooper, C.E., Sharpe, M.A. and Nicholls, P. (1990) Biochem. J. 270, 109-118). Free fatty acids present in the soybean phospholipid mixture may be responsible for such activity. ..
- Benson M, Newey S, Martin Rendon E, Hawkes R, Blake D. Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. J Biol Chem. 2001;276:24232-41 pubmed..These findings have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. ..
- Valentijn A, Gilmore A. Translocation of full-length Bid to mitochondria during anoikis. J Biol Chem. 2004;279:32848-57 pubmed..Our data indicate that Bid is important for regulating apoptosis via the intrinsic pathway and has implications for how Bid may fulfill that role. ..
- Golby P, Davies S, Kelly D, Guest J, Andrews S. Identification and characterization of a two-component sensor-kinase and response-regulator system (DcuS-DcuR) controlling gene expression in response to C4-dicarboxylates in Escherichia coli. J Bacteriol. 1999;181:1238-48 pubmed..Although all three proteins have similar topologies and functions, and all are members of the two-component sensor-kinase family, their periplasmic domains appear to have evolved independently. ..
- Clifford G, Londos C, Kraemer F, Vernon R, Yeaman S. Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes. J Biol Chem. 2000;275:5011-5 pubmed..A loss of the ability to translocate HSL to the lipid droplet probably contributes to the diminished lipolytic response to catecholamines with age. ..
- Hawkes N, Otero G, Winkler G, Marshall N, Dahmus M, Krappmann D, et al. Purification and characterization of the human elongator complex. J Biol Chem. 2002;277:3047-52 pubmed..Mutations in IKAP can result in the severe human disorder familial dysautonomia, raising the possibility that this disease might be due to compromised Elongator function and therefore could be a transcription disorder...
- Terashima A, Cotton L, Dev K, Meyer G, Zaman S, Duprat F, et al. Regulation of synaptic strength and AMPA receptor subunit composition by PICK1. J Neurosci. 2004;24:5381-90 pubmed..These findings suggest that PICK1 acts to downregulate the GluR2 content of AMPARs at hippocampal CA1 synapses, thereby increasing synaptic strength at resting membrane potentials. ..
- Smith M, Pozo K, Brickley K, Stephenson F. Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes. J Biol Chem. 2006;281:27216-28 pubmed..These findings support a role for GRIF-1 as a kinesin adaptor molecule requisite for the anterograde delivery of defined cargoes such as mitochondria and/or vesicles incorporating beta2 subunit-containing GABAA receptors, in the brain. ..
- Li H, Lu Y, Smith H, Richardson W. Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes. J Neurosci. 2007;27:14375-82 pubmed..In contrast, Olig2 does not bind to Sox10 in zebrafish, although both OLIG1 and OLIG2 bind SOX10 in mouse. ..
- Miyamoto K, Pasque V, Jullien J, Gurdon J. Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. Genes Dev. 2011;25:946-58 pubmed publisher..This is the first report showing that naturally stored actin in an oocyte nucleus helps transcriptional reprogramming in a polymerization-dependent manner. ..
- Pilecki B, Holm A, Schlosser A, Moeller J, Wohl A, Zuk A, et al. Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation. J Biol Chem. 2016;291:1103-14 pubmed publisher..Furthermore, we found that MFAP4 actively promotes tropoelastin self-assembly. In conclusion, our data identify MFAP4 as a new ligand of microfibrils and tropoelastin involved in proper elastic fiber organization. ..
- Spooner P, Rutherford N, Watts A, Henderson P. NMR observation of substrate in the binding site of an active sugar-H+ symport protein in native membranes. Proc Natl Acad Sci U S A. 1994;91:3877-81 pubmed
- Ala Aldeen D, Powell N, Wall R, Borriello S. Localization of the meningococcal receptors for human transferrin. Infect Immun. 1993;61:751-9 pubmed..This study further supports the concept of regarding the TBPs as future vaccine candidates. ..
- Gross B, Lee J, Clements J, Turner M, Tybulewicz V, Findell P, et al. Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. J Biol Chem. 1999;274:5963-71 pubmed..This work identifies SLP-76 as an important adapter molecule that is regulated by Syk and lies upstream of SLAP-130 and PLC-gamma2 in CRP-stimulated platelets. ..
- Parmentier M, Woods D, Greig S, Phan P, Radovic A, Bryant P, et al. Rapsynoid/partner of inscuteable controls asymmetric division of larval neuroblasts in Drosophila. J Neurosci. 2000;20:RC84 pubmed..Our data show that Raps is a novel protein involved in the control of asymmetric divisions of neuroblasts. ..
- Muskett P, Kahn K, Austin M, Moisan L, Sadanandom A, Shirasu K, et al. Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens. Plant Cell. 2002;14:979-92 pubmed..An absence of obvious developmental defects in null Arabidopsis rar1 mutants favors the notion that, in contrast, RAR1 does not play a fundamental role in plant development. ..
- Muller J, Shorter J, Newman R, Deinhardt K, Sagiv Y, Elazar Z, et al. Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion. J Cell Biol. 2002;157:1161-73 pubmed..We suggest that this occurs at the inception of Golgi reassembly to protect the v-SNARE and regulate SNARE function. ..
- Smith D, Naylor S, Gally D. Consequences of EHEC colonisation in humans and cattle. Int J Med Microbiol. 2002;292:169-83 pubmed..coli and lead to approaches to reduce EHEC carriage in ruminants as well as prevent or treat human disease. ..
- Townsend P, Cutress R, Sharp A, Brimmell M, Packham G. BAG-1 prevents stress-induced long-term growth inhibition in breast cancer cells via a chaperone-dependent pathway. Cancer Res. 2003;63:4150-7 pubmed..Targeting the interaction of BAG-1 with chaperones is an attractive strategy to counter the biological effects of BAG-1. ..
- Ley R, Ewings K, Hadfield K, Howes E, Balmanno K, Cook S. Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover. J Biol Chem. 2004;279:8837-47 pubmed..Our findings provide new insights into the post-translational regulation of Bim(EL) and the role of the ERK1/2 pathway in cell survival signaling. ..
- Yamano H, Kominami K, Harrison C, Kitamura K, Katayama S, Dhut S, et al. Requirement of the SCFPop1/Pop2 Ubiquitin Ligase for Degradation of the Fission Yeast S Phase Cyclin Cig2. J Biol Chem. 2004;279:18974-80 pubmed..Our results also highlight a collaborative action of the APC/C and the SCF toward the common substrate Cig2. This type of composite degradation control may be more general as the regulatory mechanism in other complex systems. ..
- Scheel Toellner D, Wang K, Craddock R, Webb P, McGettrick H, Assi L, et al. Reactive oxygen species limit neutrophil life span by activating death receptor signaling. Blood. 2004;104:2557-64 pubmed
- Palecek J, Vidot S, Feng M, Doherty A, Lehmann A. The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits. J Biol Chem. 2006;281:36952-9 pubmed..We further show that Nse3, as well as Nse5 and Nse6, also bridge the heads of Smc5 and -6. The Nse1-Nse3-Nse4 and Nse5-Nse6 subcomplexes bind to the Smc5-Smc6 heads domain at different sites. ..
- Ogura Y, Ooka T, Whale A, Garmendia J, Beutin L, Tennant S, et al. TccP2 of O157:H7 and non-O157 enterohemorrhagic Escherichia coli (EHEC): challenging the dogma of EHEC-induced actin polymerization. Infect Immun. 2007;75:604-12 pubmed publisher..These results suggest that the TccP pathway can be used by both O157 and non-O157 EHEC and that non-O157 EHEC can also trigger actin polymerization via the Nck pathway...
- Bailey L, Campbell L, Evetts K, Littlefield K, Rajendra E, Nietlispach D, et al. The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function. J Biol Chem. 2009;284:992-9 pubmed publisher..BART has faces of differing charge and structural elements, which may explain how it can interact with other proteins. ..
- Clayton E, Anggono V, Smillie K, Chau N, Robinson P, Cousin M. The phospho-dependent dynamin-syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesicles. J Neurosci. 2009;29:7706-17 pubmed publisher..The results reveal that the phospho-dependent dynamin-syndapin interaction recruits ADBE to massively increase SV endocytosis under conditions of elevated neuronal activity. ..
- Owens T, Foster F, Valentijn A, Gilmore A, Streuli C. Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization. J Biol Chem. 2010;285:1081-8 pubmed publisher..Moreover, switching the function of proteins from anti- to proapoptotic forms may be a common theme in the efficient execution of cell death. ..
- Luther P, Winkler H, Taylor K, Zoghbi M, Craig R, Padrón R, et al. Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle. Proc Natl Acad Sci U S A. 2011;108:11423-8 pubmed publisher..This binding implies a physical mechanism for communicating the relative sliding between thick and thin filaments that does not involve myosin and which could modulate the contractile process...
- So E, Schroeder G, Carson D, Mattheis C, Mousnier A, Broncel M, et al. The Rab-binding Profiles of Bacterial Virulence Factors during Infection. J Biol Chem. 2016;291:5832-43 pubmed publisher..Taken together, this study illustrates the power of this approach to profile the intracellular interactomes of bacterial effectors during infection. ..
- Rajgor D, Fiuza M, Parkinson G, Hanley J. The PICK1 Ca2+ sensor modulates N-methyl-d-aspartate (NMDA) receptor-dependent microRNA-mediated translational repression in neurons. J Biol Chem. 2017;292:9774-9786 pubmed publisher..Our work suggests a Ca2+-dependent process to regulate miRNA activity in neurons in response to the induction of long-term depression. ..
- Lee J, Lau K, Perkinton M, Standen C, Rogelj B, Falinska A, et al. The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice. J Biol Chem. 2004;279:49099-104 pubmed..Our findings suggest that modulation of X11beta function may represent a novel therapeutic approach for preventing the amyloid pathology of Alzheimer's disease. ..
- Barton C, Whitehead S, Blackwell J. Nramp transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: influence on oxidative burst and nitric oxide pathways. Mol Med. 1995;1:267-79 pubmed
- Zahn R, Buckle A, Perrett S, Johnson C, Corrales F, Golbik R, et al. Chaperone activity and structure of monomeric polypeptide binding domains of GroEL. Proc Natl Acad Sci U S A. 1996;93:15024-9 pubmed..The function of the allosteric behavior on the binding of GroES and ATP must be to regulate the affinity of the protein for its various substrates in vivo, where the cavity may also be required for special functions...
- Ardley H, Tan N, Rose S, Markham A, Robinson P. Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. J Biol Chem. 2001;276:19640-7 pubmed..These studies demonstrate that very subtle changes to the domains that regulate recognition between highly conserved components of the ubiquitin pathway can dramatically affect their ability to interact. ..
- Mason M, Lieberman A, Grenningloh G, Anderson P. Transcriptional upregulation of SCG10 and CAP-23 is correlated with regeneration of the axons of peripheral and central neurons in vivo. Mol Cell Neurosci. 2002;20:595-615 pubmed..Thus, SCG10 and CAP-23, as well as GAP-43, are likely to be important neuronal determinants of regenerative ability. ..
- Boyd G, Low P, Dunlop J, Robertson L, Vardy A, Lambert J, et al. Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins. Mol Cell Neurosci. 2002;21:38-50 pubmed..In support of the existence of homomeric 5-HT3 receptors in vivo, recombinantly expressed 5-HT3A receptors were capable of clustered cell surface expression in cortical neurons. ..
- Mitchell R, Farrington S, Dunlop M, Campbell H. Mismatch repair genes hMLH1 and hMSH2 and colorectal cancer: a HuGE review. Am J Epidemiol. 2002;156:885-902 pubmed..Population screening for mutation carriers is not currently a feasible option, and mutation analysis remains restricted to either relatives of mutation carriers or colorectal cancer cases selected on the basis of phenotype. ..
- Sunters A, Fernandez De Mattos S, Stahl M, Brosens J, Zoumpoulidou G, Saunders C, et al. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem. 2003;278:49795-805 pubmed..This is the first demonstration that up-regulation of FoxO3a by paclitaxel can result in increased levels of Bim mRNA and protein, which can be a direct cause of apoptosis in breast cancer cells. ..
- Jeffries T, Dove S, Michell R, Parker P. PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. Mol Biol Cell. 2004;15:2652-63 pubmed..We conclude that WIPI49 is a novel regulatory component of the endosomal and MPR pathway and that this role is dependent upon the PI-binding properties of its WD40 domain...
- Carlton J, Bujny M, Peter B, Oorschot V, Rutherford A, Mellor H, et al. Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. Curr Biol. 2004;14:1791-800 pubmed
- Loewen C, Levine T. A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. J Biol Chem. 2005;280:14097-104 pubmed..Finally, we found that human VAP-A could substitute for Scs2 but that it functioned poorly, suggesting that other factors modulate the binding of Scs2 to proteins with FFAT motifs. ..
- Errico A, Costanzo V, Hunt T. Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts. Proc Natl Acad Sci U S A. 2007;104:14929-34 pubmed..Tipin-depleted extracts also showed defects in the activation of Chk1 in response to aphidicolin, probably because of a failure to load the checkpoint mediator protein Claspin onto chromatin. ..
- Martin Serrano J, Marsh M. ALIX catches HIV. Cell Host Microbe. 2007;1:5-7 pubmed..One of these studies provides the clearest evidence to date that ESCRT-III mediates key events in virus release and indicates that there are cellular proteins involved in this process still to be discovered. ..
- Leznicki P, High S. SGTA antagonizes BAG6-mediated protein triage. Proc Natl Acad Sci U S A. 2012;109:19214-9 pubmed publisher..We speculate that a BAG6/SGTA cycle operates during protein maturation and quality control in the cytosol and that together these components dictate the fate of a specific subset of newly synthesized proteins. ..
- Manifava M, Thuring J, Lim Z, Packman L, Holmes A, Ktistakis N. Differential binding of traffic-related proteins to phosphatidic acid- or phosphatidylinositol (4,5)- bisphosphate-coupled affinity reagents. J Biol Chem. 2001;276:8987-94 pubmed..Binding to PA may be a property linking together distinct participants in one complete round of membrane transport from a donor to an acceptor compartment. ..
- Young P, Le T, Dunckley M, Nguyen T, Burghes A, Morris G. Nuclear gems and Cajal (coiled) bodies in fetal tissues: nucleolar distribution of the spinal muscular atrophy protein, SMN. Exp Cell Res. 2001;265:252-61 pubmed..These unusual features of motor neurons may relate to their special sensitivity to reduced SMN levels in SMA patients. ..
- Ali I, McKendrick L, Morley S, Jackson R. Activity of the hepatitis A virus IRES requires association between the cap-binding translation initiation factor (eIF4E) and eIF4G. J Virol. 2001;75:7854-63 pubmed
- Kearns A, Graham C, Burdess D, Heatherington J, Freeman R. Rapid real-time PCR for determination of penicillin susceptibility in pneumococcal meningitis, including culture-negative cases. J Clin Microbiol. 2002;40:682-4 pubmed..pneumoniae was detected in all instances. Real-time PCR proved more sensitive than culture, microscopy, or antigen detection and provided susceptibility data even in culture-negative cases. ..
- Beck M, Brickley K, Wilkinson H, Sharma S, Smith M, Chazot P, et al. Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1. J Biol Chem. 2002;277:30079-90 pubmed..The respective GABA(A) receptor beta 2 subunit/GRIF-1 binding domains were mapped using the yeast two-hybrid reporter gene assays. A possible role for GRIF-1 as a GABA(A) receptor beta 2 subunit trafficking factor is proposed. ..
- Konstas A, Shearwin Whyatt L, Fotia A, Degger B, Riccardi D, Cook D, et al. Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. J Biol Chem. 2002;277:29406-16 pubmed..Because N4WBP5A is highly expressed in native renal collecting duct and other tissues that express ENaC, it is a likely candidate to modulate ENaC function in vivo. ..
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