Experts and Doctors on carrier proteins in Germany

Summary

Locale: Germany
Topic: carrier proteins

Top Publications

  1. Kempf B, Bremer E. OpuA, an osmotically regulated binding protein-dependent transport system for the osmoprotectant glycine betaine in Bacillus subtilis. J Biol Chem. 1995;270:16701-13 pubmed
    ..Physical and genetic mapping experiments allowed the positioning the opuA operon at 25 degrees on the genetic map of B. subtilis. ..
  2. Suppmann B, Sawers G. Isolation and characterization of hypophosphite--resistant mutants of Escherichia coli: identification of the FocA protein, encoded by the pfl operon, as a putative formate transporter. Mol Microbiol. 1994;11:965-82 pubmed
    ..coli and the FdhC protein of Methanobacterium formicicum. All three proteins are predicted to be integral membrane proteins. A detailed in vivo TnphoA mutagenesis study predicted that FocA has six membrane-spanning segments. ..
  3. Rottbauer W, Gautel M, Zehelein J, Labeit S, Franz W, Fischer C, et al. Novel splice donor site mutation in the cardiac myosin-binding protein-C gene in familial hypertrophic cardiomyopathy. Characterization Of cardiac transcript and protein. J Clin Invest. 1997;100:475-82 pubmed
  4. Marie Cardine A, Kirchgessner H, Schraven B. Molecular alterations of the Fyn-complex occur as late events of human T cell activation. Eur J Immunol. 1999;29:1175-87 pubmed
    ..Moreover, the analogous constitutive alterations in transformed T cell lines could indicate that deregulation of the Fyn-complex might be functionally associated with the malignant phenotype of these cells. ..
  5. Frankenberg N, Welker C, Jaenicke R. Does the elimination of ion pairs affect the thermal stability of cold shock protein from the hyperthermophilic bacterium Thermotoga maritima?. FEBS Lett. 1999;454:299-302 pubmed
    ..The results are in agreement with preliminary NMR data which confirm the predicted structure only for the N-terminal ion pair. ..
  6. Caramel A, Schnetz K. Antagonistic control of the Escherichia coli bgl promoter by FIS and CAP in vitro. Mol Microbiol. 2000;36:85-92 pubmed
    ..These results suggest that FIS contributes to silencing of the wild-type bgl promoter in vivo, presumably in the early exponential phase when FIS is predominantly expressed. ..
  7. Hayer M, Bonisch H, Bruss M. Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1). Ann Hum Genet. 1999;63:473-82 pubmed
    ..When stably expressed in human embryonic kidney (HEK293) cells, only the full length hOCT1 cDNA mediated decynium-22 (D22)-sensitive uptake of tritiated 1-methyl-4-phenylpyridinium ([3H]-MPP+). ..
  8. Wentzel A, Christmann A, Adams T, Kolmar H. Display of passenger proteins on the surface of Escherichia coli K-12 by the enterohemorrhagic E. coli intimin EaeA. J Bacteriol. 2001;183:7273-84 pubmed
    ..coli and their exposure on the cell surface. Intimin display may prove a useful tool for future protein translocation studies with interesting biological and biotechnological ramifications. ..
  9. Pollok S, Stoepel J, Bauerschmidt C, Kremmer E, Nasheuer H. Regulation of eukaryotic DNA replication at the initiation step. Biochem Soc Trans. 2003;31:266-9 pubmed
    ..New phosphorylation-specific antibodies specifically recognize the phosphorylated subunit, p68, of the four subunit DNA polymerase alpha-primase and show that the phosphorylated polypeptide is exclusively nuclear. ..

More Information

Publications267 found, 100 shown here

  1. Mokranjac D, Paschen S, Kozany C, Prokisch H, Hoppins S, Nargang F, et al. Tim50, a novel component of the TIM23 preprotein translocase of mitochondria. EMBO J. 2003;22:816-25 pubmed
    ..We suggest that Tim50 plays a crucial role in the transfer of preproteins from the TOM complex to the TIM23 complex through the intermembrane space. ..
  2. Suesslin C, Frohnmeyer H. An Arabidopsis mutant defective in UV-B light-mediated responses. Plant J. 2003;33:591-601 pubmed
    ..ULI3 is preferentially expressed in the outer cell layers in leaves, stems and flowers, but not in roots. There is evidence that ULI3 represents a specific component involved in UV-B-mediated signal transduction in higher plants. ..
  3. Kruljac Letunic A, Moelleken J, Kallin A, Wieland F, Blaukat A. The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1. J Biol Chem. 2003;278:29560-70 pubmed
    ..We therefore provide evidence for a functional interaction between Pyk2 and ASAP1 and a regulation of ASAP1 and hence Arf1 activity by Pyk2-mediated tyrosine phosphorylation. ..
  4. Schaaf G, Ludewig U, Erenoglu B, Mori S, Kitahara T, von Wirén N. ZmYS1 functions as a proton-coupled symporter for phytosiderophore- and nicotianamine-chelated metals. J Biol Chem. 2004;279:9091-6 pubmed
    ..These biochemical properties indicate a novel role of YS1 transporters for heavy metal homeostasis in plants. ..
  5. Fricke J, Voss C, Thumm M, Meyers G. Processing of a pestivirus protein by a cellular protease specific for light chain 3 of microtubule-associated proteins. J Virol. 2004;78:5900-12 pubmed
  6. Büttner B, Kannicht C, Reutter W, Horstkorte R. Novel cytosolic binding partners of the neural cell adhesion molecule: mapping the binding domains of PLC gamma, LANP, TOAD-64, syndapin, PP1, and PP2A. Biochemistry. 2005;44:6938-47 pubmed
    ..For this purpose, we performed GST pull-down experiments using cytosolic fragments of NCAM as GST-fusion proteins and cytosolic- or cytoskeleton-enriched protein fractions of rat brain. ..
  7. Xiao F, Mirwald A, Papaioannou M, Baniahmad A, Klug J. Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors. Mol Endocrinol. 2005;19:2964-78 pubmed
    ..Therefore we propose that SCGB 2A1 represents a new class of androgen target genes that are purely under indirect AR control mediated by DNA-bound Sp factors. ..
  8. Rumpf S, Jentsch S. Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone. Mol Cell. 2006;21:261-9 pubmed
    ..We propose that the balance between the distinct substrate-processing cofactors may determine whether a substrate is multiubiquitylated and routed to the proteasome for degradation or deubiquitylated and/or released for other purposes. ..
  9. Siemieniewicz K, Kajla M, Schrempf H. Elucidating the biosynthesis of chitin filaments and their configuration with specific proteins and electron microscopy. Macromol Biosci. 2007;7:40-7 pubmed publisher
    ..The presented data give new insights to the generation of chitin filaments with an antiparallel (alpha) configuration. [image: see text]..
  10. Rother K, Dengl M, Lorenz J, Tschop K, Kirschner R, Mossner J, et al. Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73. FEBS Lett. 2007;581:1166-72 pubmed
    ..Thus p53, rather than its homologues p63 and p73, may contribute to control of the first metaphase/anaphase transition of mammalian meiosis by downregulation of Cks2 expression. ..
  11. Li Y, Ghavampur S, Bondallaz P, Will L, Grenningloh G, Püschel A. Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10. J Biol Chem. 2009;284:363-71 pubmed publisher
    ..The effect of Rnd1 on axon extension depends on SCG10. These results indicate that SCG10 acts as an effector downstream of Rnd1 to regulate axon extensions by modulating microtubule organization. ..
  12. Ortiz de Orué Lucana D, Groves M. The three-component signalling system HbpS-SenS-SenR as an example of a redox sensing pathway in bacteria. Amino Acids. 2009;37:479-86 pubmed publisher
    ..The presented report reviews the current knowledge of the function of this novel protein family consisting of an accessory protein and its cognate two-component system, which could be more properly described as a three-component system. ..
  13. Reiss J, Hahnewald R. Molybdenum cofactor deficiency: Mutations in GPHN, MOCS1, and MOCS2. Hum Mutat. 2011;32:10-8 pubmed publisher
    ..For type A deficiency an effective substitution therapy has been described recently. ..
  14. Weikart N, Sommer S, Mootz H. Click synthesis of ubiquitin dimer analogs to interrogate linkage-specific UBA domain binding. Chem Commun (Camb). 2012;48:296-8 pubmed publisher
    ..Binding studies with the Lys48-specific UBA domain of the Mud1 protein suggest that they represent functionally suitable surrogates of their native counterparts linked by an isopeptide bond...
  15. Hussain M, Baig S, Neumann S, Nurnberg G, Farooq M, Ahmad I, et al. A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function. Am J Hum Genet. 2012;90:871-8 pubmed publisher
  16. Thomas C, Jacobs E, Dumke R. Characterization of pyruvate dehydrogenase subunit B and enolase as plasminogen-binding proteins in Mycoplasma pneumoniae. Microbiology. 2013;159:352-65 pubmed publisher
    ..The data indicate that the plasminogen-binding enzymes enolase and especially the surface-associated PDHB may contribute to the pathogenesis of M. pneumoniae infections...
  17. Ottens F, Boehm V, Sibley C, Ule J, Gehring N. Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates. RNA. 2017;23:1224-1236 pubmed publisher
    ..This suggests that the extent to which SMG6 and SMG7 degrade NMD substrates is determined by the mRNA architecture. ..
  18. Porzgen P, Bonisch H, Bruss M. Molecular cloning and organization of the coding region of the human norepinephrine transporter gene. Biochem Biophys Res Commun. 1995;215:1145-50 pubmed
    ..All exon-intron junctions contain the gt/ag consensus splice site. Knowledge of the gene structure of the antidepressant-sensitive hNET should facilitate investigation of its potential role in psychiatric disorders. ..
  19. Weichart D, Lange R, Henneberg N, Hengge Aronis R. Identification and characterization of stationary phase-inducible genes in Escherichia coli. Mol Microbiol. 1993;10:407-20 pubmed
    ..csi-17(glpD)::lacZ was shown to produce its own glucose-starvation induction, thus illustrating the intricacies of gene-fusion technology when applied to the study of gene regulation. ..
  20. Wisniewski E, Kunz W, Gellerich F. Phosphate affects the distribution of flux control among the enzymes of oxidative phosphorylation in rat skeletal muscle mitochondria. J Biol Chem. 1993;268:9343-6 pubmed
    ..This indicates that under the conditions of intermediate state respiration, all of the other reactions have a negligible controlling influence on oxidative phosphorylation in skeletal muscle mitochondria. ..
  21. Wilmen A, Hegemann J. The chromatin of the Saccharomyces cerevisiae centromere shows cell-type specific changes. Chromosoma. 1996;104:489-503 pubmed
    ..Thus the structural analysis of the centromere in different cell types provides evidence about the requirement of CEN DNA/protein complexes in different cell types and in different stages of the cell cycle. ..
  22. Raabe M, Seedorf U, Hameister H, Ellinghaus P, Assmann G. Structure and chromosomal assignment of the murine sterol carrier protein 2 gene (Scp2) and two related pseudogenes by in situ hybridization. Cytogenet Cell Genet. 1996;73:279-81 pubmed
    ..We found the overall structure of murine Scp2 to be identical to that of the human SCP2 gene. In addition, two Scp2 pseudogenes have been isolated and mapped to chromosomes 3H2-->4 and 9F. ..
  23. Dietmeier K, Hönlinger A, Bömer U, Dekker P, Eckerskorn C, Lottspeich F, et al. Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Nature. 1997;388:195-200 pubmed
    ..We conclude that Tom5 represents a functional link between surface receptors and GIP, and is part of an 'acid chain' that guides the stepwise transport of positively charged mitochondrial targeting sequences. ..
  24. Gebauer M, Zeiner M, Gehring U. Proteins interacting with the molecular chaperone hsp70/hsc70: physical associations and effects on refolding activity. FEBS Lett. 1997;417:109-13 pubmed
    ..These interacting proteins thus appear to cooperate in affecting the chaperoning activity of hsp70/hsc70. ..
  25. Welz D, Braun V. Ferric citrate transport of Escherichia coli: functional regions of the FecR transmembrane regulatory protein. J Bacteriol. 1998;180:2387-94 pubmed
  26. Frank S, Stallmeyer B, Kämpfer H, Kolb N, Pfeilschifter J. Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair. J Clin Invest. 2000;106:501-9 pubmed
    ..Therefore, leptin might represent an effective novel therapeutic factor to improve impaired wound-healing conditions. ..
  27. Gleiter S, Lilie H. Coupling of antibodies via protein Z on modified polyoma virus-like particles. Protein Sci. 2001;10:434-44 pubmed
    ..Using this fusion protein, we could change the tropism of polyoma VLPs toward cells presenting on their surface the antigen of the coupled antibody. ..
  28. Tschesche H, Zölzer V, Triebel S, Bartsch S. The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases. Eur J Biochem. 2001;268:1918-28 pubmed
  29. Rohde G, Wenzel D, Haucke V. A phosphatidylinositol (4,5)-bisphosphate binding site within mu2-adaptin regulates clathrin-mediated endocytosis. J Cell Biol. 2002;158:209-14 pubmed
    ..We suggest that PI(4,5)P2 binding to mu2-adaptin regulates clathrin-mediated endocytosis and thereby may contribute to structurally linking cargo recognition to coat formation. ..
  30. Graf R, Freyberg M, Kaiser D, Friedl P. Mechanosensitive induction of apoptosis in fibroblasts is regulated by thrombospondin-1 and integrin associated protein (CD47). Apoptosis. 2002;7:493-8 pubmed
    ..The presented mechanosensitive regulation of apoptosis in fibroblast cultures could be an essential mechanism for the regression of the granulation tissue by apoptosis in the process of wound healing. ..
  31. Hatsuzawa K, Lang T, Fasshauer D, Bruns D, Jahn R. The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis. J Biol Chem. 2003;278:31159-66 pubmed
    ..We conclude that tomosyn is a soluble SNARE that directly competes with synaptobrevin in the formation of SNARE complexes and thus may function in down-regulating exocytosis. ..
  32. Lamla T, Erdmann V. The Nano-tag, a streptavidin-binding peptide for the purification and detection of recombinant proteins. Protein Expr Purif. 2004;33:39-47 pubmed
    ..Additionally, the Nano-tag allowed the detection of recombinant proteins on Western blots by a streptavidin-alkaline phosphatase conjugate. ..
  33. Wojcik S, Rhee J, Herzog E, Sigler A, Jahn R, Takamori S, et al. An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size. Proc Natl Acad Sci U S A. 2004;101:7158-63 pubmed
    ..These results show that the expression level of VGLUTs determines the amount of glutamate that is loaded into vesicles and released and thereby regulates the efficacy of neurotransmission. ..
  34. Dietz A, Logothetis C, Helbig M, Flechtenmacher C, Rudat V, Dollner R, et al. Prognostic impact of EBV-related LMP-1, histologic type, and environmental factors in nasopharyngeal carcinoma in a German population. Onkologie. 2004;27:345-50 pubmed
    ..e. tobacco, alcohol and occupational hazardous substances, in nasopharyngeal carcinoma (NPC) in a German population...
  35. Lackner T, Muller A, Konig M, Thiel H, Tautz N. Persistence of bovine viral diarrhea virus is determined by a cellular cofactor of a viral autoprotease. J Virol. 2005;79:9746-55 pubmed
    ..These results add an entirely novel aspect to the understanding of the molecular basis of viral persistence...
  36. Kremerskothen J, Kindler S, Finger I, Veltel S, Barnekow A. Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring. J Neurochem. 2006;96:1659-66 pubmed
    ..Its nuclear localization capacity further points to a function in retrograde signaling from the synapse to the nucleus. ..
  37. Glienke W, Chow K, Bauer N, Bergmann L. Down-regulation of wt1 expression in leukemia cell lines as part of apoptotic effect in arsenic treatment using two compounds. Leuk Lymphoma. 2006;47:1629-38 pubmed
    ..The therapeutic effect of arsenic is the induction of apoptosis by modulating the gene expression profile of pro- and anti-apoptotic genes including the wt1 gene. ..
  38. Waldeck W, Pipkorn R, Korn B, Mueller G, Schick M, Toth K, et al. Transporter molecules influence the gene expression in HeLa cells. Int J Med Sci. 2009;6:18-27 pubmed
    ..The PKN1 gene was induced and two genes (ZCD1 and BSG) were slightly repressed. The genes and the chromosomes are described, the moderate differential gene expression graphed, and the ontology is listed. ..
  39. O Sullivan G, Jedlicka P, Chen H, Kalbouneh H, Ippolito A, Deller T, et al. Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice. Mol Cell Neurosci. 2016;72:101-13 pubmed publisher
    ..The fact that these mice display behavioural features of anxiety and epilepsy emphasises the importance of postsynaptic γ2-GABAAR clustering for synaptic inhibition. ..
  40. Schmidt I, Schoelch C, Ziska T, Schneider D, Simon E, Plagemann A. Interaction of genetic and environmental programming of the leptin system and of obesity disposition. Physiol Genomics. 2000;3:113-20 pubmed
    ..By early postnatal overfeeding an usually inconspicuous genetic trait may thus become etiologic for the development of obesity via physiological changes other than the decreased leptin binding characterizing the genetic defect...
  41. Koroll M, Rathjen F, Volkmer H. The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. J Biol Chem. 2001;276:10646-54 pubmed
    ..Finally, we report that syntenin-1 and -2 both form homodimers and can interact with each other. ..
  42. Simic P, Willuhn J, Sahm H, Eggeling L. Identification of glyA (encoding serine hydroxymethyltransferase) and its use together with the exporter ThrE to increase L-threonine accumulation by Corynebacterium glutamicum. Appl Environ Microbiol. 2002;68:3321-7 pubmed
    ..This shows that the potential for amino acid formation can be considerably improved by reducing its intracellular degradation and increasing its export...
  43. Horstkotte M, Knobloch J, Rohde H, Dobinsky S, Mack D. Rapid detection of methicillin resistance in coagulase-negative Staphylococci with the VITEK 2 system. J Clin Microbiol. 2002;40:3291-5 pubmed
    ..The results of our study encourage the use of the VITEK 2 system, which proved to be a highly reliable and rapid phenotypic method for the detection of methicillin resistance in CoNS. ..
  44. Myssina S, Huber S, Birka C, Lang P, Lang K, Friedrich B, et al. Inhibition of erythrocyte cation channels by erythropoietin. J Am Soc Nephrol. 2003;14:2750-7 pubmed
    ..The effect could prolong the erythrocyte lifespan and may contribute to the enhancement of the erythrocyte number during erythropoietin therapy in dialysis patients. ..
  45. Rotzoll D, Scherling R, Etzl R, Stepan H, Horn L, Pöschl J. Immunohistochemical localization of alpha-tocopherol transfer protein and lipoperoxidation products in human first-trimester and term placenta. Eur J Obstet Gynecol Reprod Biol. 2008;140:183-91 pubmed publisher
  46. Tatsuta T, Scharwey M, Langer T. Mitochondrial lipid trafficking. Trends Cell Biol. 2014;24:44-52 pubmed publisher
    ..Here, we summarize the current understanding of lipid trafficking at the mitochondria and discuss emerging models for the mechanisms of lipid transfer. ..
  47. Etard C, Wedlich D, Bauer A, Huber O, Kuhl M. Expression of Xenopus homologs of the beta-catenin binding protein pontin52. Mech Dev. 2000;94:219-22 pubmed
    ..Xreptin is also expressed in neural crest cells, in particular in a subpopulation that give raise to the adrenal medulla. ..
  48. Jahn O, Radulovic J, Stiedl O, Tezval H, Eckart K, Spiess J. Corticotropin-releasing factor binding protein--a ligand trap?. Mini Rev Med Chem. 2005;5:953-60 pubmed
    ..This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors. ..
  49. Georgi A, Jamra R, Klein K, Villela A, Schumacher J, Becker T, et al. Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample. Psychiatr Genet. 2007;17:308-10 pubmed
    ..Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia. ..
  50. Bertz M, Rief M. Mechanical unfoldons as building blocks of maltose-binding protein. J Mol Biol. 2008;378:447-58 pubmed publisher
    ..We showed that many MBP constructs composed of those building blocks indeed form stably folded structures in solution. Mechanical unfoldons may provide a new tool for a systematic search for stable substructures of large proteins. ..
  51. Beli P, Mascheroni D, Xu D, Innocenti M. WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2. Nat Cell Biol. 2008;10:849-57 pubmed publisher
    ..Thus, WAVE and the Arp2/3 complex jointly orchestrate different types of actin-based plasma membrane protrusions by promoting ruffling and inhibiting mDia2-induced filopodia. ..
  52. Grininger M, Staudt H, Johansson P, Wachtveitl J, Oesterhelt D. Dodecin is the key player in flavin homeostasis of archaea. J Biol Chem. 2009;284:13068-76 pubmed publisher
    ..Intriguingly, the different structural and functional properties of a homologous bacterial dodecin suggest that dodecin has different roles in different kingdoms of life...
  53. Grotemeier A, Alers S, Pfisterer S, Paasch F, Daubrawa M, Dieterle A, et al. AMPK-independent induction of autophagy by cytosolic Ca2+ increase. Cell Signal. 2010;22:914-25 pubmed publisher
    ..We suggest that apart from reported AMPK-dependent regulation of autophagic degradation, an AMPK-independent pathway triggers Ca(2+)-mediated autophagy, involving the PI(3)P-effector protein WIPI-1 and LC3...
  54. Niesmann K, Breuer D, Brockhaus J, Born G, Wolff I, Reissner C, et al. Dendritic spine formation and synaptic function require neurobeachin. Nat Commun. 2011;2:557 pubmed publisher
  55. Seedorf U, Raabe M, Assmann G. Cloning, expression and sequences of mouse sterol-carrier protein-x-encoding cDNAs and a related pseudogene. Gene. 1993;123:165-72 pubmed
    ..Therefore, our results indicate that at least some of the multiple restriction fragments which are detected by Southern hybridization analyses with SCP-x cDNA-derived probes can be explained by cross-hybridization with a pseudogene. ..
  56. Schumann R. Mechanisms of transcriptional activation of lipopolysaccharide binding protein (LBP). Prog Clin Biol Res. 1995;392:297-304 pubmed
    ..Elucidation of the transcriptional activation mechanism could point the way to a therapeutically lowering of LBP levels in high risk patients for reducing their susceptibility to Gram-negative septic shock. ..
  57. Schmidt B, Tradler T, Rahfeld J, Ludwig B, Jain B, Mann K, et al. A cyclophilin-like peptidyl-prolyl cis/trans isomerase from Legionella pneumophila--characterization, molecular cloning and overexpression. Mol Microbiol. 1996;21:1147-60 pubmed
    ..Like human cyclophilin, the L. p. Cyp18 exhibits nuclease activity, but this enzymatic activity does not appear to be linked with the native structure of the protein. ..
  58. Brix J, Rudiger S, Bukau B, Schneider Mergener J, Pfanner N. Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein. J Biol Chem. 1999;274:16522-30 pubmed
  59. Moro F, Sirrenberg C, Schneider H, Neupert W, Brunner M. The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix. EMBO J. 1999;18:3667-75 pubmed
    ..Tim44 forms dimers which recruit two molecules of mt-Hsp70 to the sites of protein import. A sequential, hand-over-hand mode of interaction of these two mt-Hsp70.Tim44 complexes with a translocating polypeptide chain is proposed. ..
  60. Witte W. Antibiotic resistance in gram-positive bacteria: epidemiological aspects. J Antimicrob Chemother. 1999;44 Suppl A:1-9 pubmed
    ..pneumoniae, as well as to the spread of resistance genes as exemplified by those causing glycopeptide resistance in enterococci. ..
  61. Mägert H, Kreutzmann P, Drögemüller K, Ständker L, Adermann K, Walden M, et al. The 15-domain serine proteinase inhibitor LEKTI: biochemical properties, genomic organization, and pathophysiological role. Eur J Med Res. 2002;7:49-56 pubmed
    ..Furthermore, the relevance of LEKTI for several disorders pointing out its possible future therapeutic value, is discussed. ..
  62. Lossdörfer S, Gotz W, Jager A. Immunohistochemical localization of receptor activator of nuclear factor kappaB (RANK) and its ligand (RANKL) in human deciduous teeth. Calcif Tissue Int. 2002;71:45-52 pubmed
  63. Kuersten S, Arts G, Walther T, Englmeier L, Mattaj I. Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains. Mol Cell Biol. 2002;22:5708-20 pubmed
    ..We propose that these interactions increase the concentration of tRNA export complexes and of empty Xpo-t in the vicinity of NPCs and thus increase the efficiency of the Xpo-t transport cycle. ..
  64. Weinmann M, Jendrossek V, Handrick R, Güner D, Goecke B, Belka C. Molecular ordering of hypoxia-induced apoptosis: critical involvement of the mitochondrial death pathway in a FADD/caspase-8 independent manner. Oncogene. 2004;23:3757-69 pubmed
    ..Thus, in human tumors, hypoxia will mainly lead to the selection of hypoxia-resistant cells with defects in mitochondrial apoptosis signaling pathways. ..
  65. Foltz M, Oechsler C, Boll M, Kottra G, Daniel H. Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2. Eur J Biochem. 2004;271:3340-7 pubmed
    ..Maximal transport currents are substrate-dependent which suggests that the translocation of the loaded carrier to the internal side is the rate-limiting step. ..
  66. Zhang Z, Weinschenk T, Schluesener H. Uptake, intracellular distribution, and novel binding proteins of immunostimulatory CpG oligodeoxynucleotides in microglial cells. J Neuroimmunol. 2005;160:32-40 pubmed
    ..These findings are helpful in understanding the cellular fate of ODN and the nonsequence-specific effects of ODN and for rational design and evaluation of ODN-based therapeutic strategies. ..
  67. Sarikas A, Carrier L, Schenke C, Doll D, Flavigny J, Lindenberg K, et al. Impairment of the ubiquitin-proteasome system by truncated cardiac myosin binding protein C mutants. Cardiovasc Res. 2005;66:33-44 pubmed
    ..Since the UPS plays an important role in a variety of fundamental cellular processes, we propose impairment of this system by mutant cMyBP-Cs as a contributing factor to the pathogenesis of FHC. ..
  68. Kaumanns P, Hagmann I, Dittmar M. Human TRIM5alpha mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants. Retrovirology. 2006;3:79 pubmed
    ..2 and 19.6 fold restriction). ..
  69. Luci S, Giemsa B, Kluge H, Eder K. Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs. Am J Physiol Regul Integr Comp Physiol. 2007;293:R70-7 pubmed
    ..It is also shown that PPAR-alpha activation by clofibrate does not affect hepatic expression of SREBP target genes involved in synthesis of triglycerides and cholesterol homeostasis in liver and adipose tissue of pigs...
  70. Weiss S, Ladwein M, Schmidt D, Ehinger J, Lommel S, Städing K, et al. IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. Cell Host Microbe. 2009;5:244-58 pubmed publisher
    ..Genetic and functional loss of IRSp53 abrogates actin assembly mediated by EHEC. Collectively, these data indentify IRSp53 family proteins as the missing host cell factors linking bacterial Tir and EspF(U) in EHEC pedestal formation. ..
  71. Bielig H, Zurek B, Kutsch A, Menning M, Philpott D, Sansonetti P, et al. A function for AAMP in Nod2-mediated NF-kappaB activation. Mol Immunol. 2009;46:2647-54 pubmed publisher
    ..Taken together, our data support a new function of AAMP in regulating innate immune responses initiated by the NLR protein Nod2. ..
  72. Voss M, Lettau M, Janssen O. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. BMC Immunol. 2009;10:53 pubmed publisher
    ..We provide an extended list of putative Fas ligand interaction partners, confirming previously identified interactions, but also introducing several novel SH3 domain proteins that might be important regulators of Fas ligand function. ..
  73. Hölsken A, Gebhardt M, Buchfelder M, Fahlbusch R, Blumcke I, Buslei R. EGFR signaling regulates tumor cell migration in craniopharyngiomas. Clin Cancer Res. 2011;17:4367-77 pubmed publisher
    ..Targeting the EGFR signaling pathway by gefitinib may present a promising pharmacologic option in the treatment of this challenging tumor disease. ..
  74. Kuhnert A, Schmidt U, Monajembashi S, Franke C, Schlott B, Grosse F, et al. Proteomic identification of PSF and p54(nrb) as TopBP1-interacting proteins. J Cell Biochem. 2012;113:1744-53 pubmed publisher
    ..Both p54(nrb) and PSF disappeared after 20 s while TopBP1 was retained at damage sites significantly longer suggesting different functions of the proteins during DSB recognition and repair. ..
  75. Dumont V, Tolvanen T, Kuusela S, Wang H, Nyman T, Lindfors S, et al. PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease. FASEB J. 2017;31:3978-3990 pubmed publisher
    ..Tolvanen, T. A., Kuusela, S., Wang, H., Nyman, T. A., Lindfors, S., Tienari, J., Nisen, H., Suetsugu, S., Plomann, M., Kawachi, H., Lehtonen, S. PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease. ..
  76. Schneider E, Francoz E, Dassa E. Completion of the nucleotide sequence of the 'maltose B' region in Salmonella typhimurium: the high conservation of the malM gene suggests a selected physiological role for its product. Biochim Biophys Acta. 1992;1129:223-7 pubmed
    ..The malM gene, encoding a periplasmic protein of unknown function in Escherichia coli, is a highly conserved as genes encoding proteins of known function from the same region...
  77. Bruss M, Kunz J, Lingen B, Bonisch H. Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter. Hum Genet. 1993;91:278-80 pubmed
    ..2. In addition, evidence is presented for an intron-exon structure of the gene. ..
  78. Dekker P, Ryan M, Brix J, Muller H, Hönlinger A, Pfanner N. Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Mol Cell Biol. 1998;18:6515-24 pubmed
    ..ii) Tom20 and Tom70 are not essential for the generation of the GIP complex. (iii) Tom6 functions as an assembly factor for Tom22, promoting its stable association with Tom40. ..
  79. Borm P, van Hartingsveld B, Schins P, Alfaro Moreno E, Cruz Rico G, Rosas Perez I, et al. Priming of cytokine release and increased levels of bactericidal permeability-increasing protein in the blood of animal facility workers. Int Arch Occup Environ Health. 1999;72:323-9 pubmed
    ..A profound effect on the cellular immune response was seen in animal workers with low endotoxin exposure and a high antigenic load. It remains to be determined which other biologically active substance(s) are involved in this effect. ..
  80. Antonin W, Wagner M, Riedel D, Brose N, Jahn R. Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion. Mol Cell Biol. 2002;22:1545-54 pubmed
    ..Furthermore, the rates of both protein synthesis and intracellular transport of secretory proteins were reduced. We conclude that syncollin plays a role in maturation and/or concentration of zymogens in zymogen granules. ..
  81. von Baum H, Schmidt C, Svoboda D, Bock Hensley O, Wendt C. Risk factors for methicillin-resistant Staphylococcus aureus carriage in residents of German nursing homes. Infect Control Hosp Epidemiol. 2002;23:511-5 pubmed
    ..Apart from well-known risk factors for the acquisition of MRSA, we identified the size of the nursing home as an independent risk factor. This might be due to an increased use of and microbials in nursing homes of a certain size. ..
  82. Vollbrandt T, Willkomm D, Stossberg H, Kruse C. Vigilin is co-localized with 80S ribosomes and binds to the ribosomal complex through its C-terminal domain. Int J Biochem Cell Biol. 2004;36:1306-18 pubmed
    ..Therefore our results provide strong evidence that vigilin is bond to the ribosomal complex and underline the hypothesis that vigilin might be involved in the link between tRNA-export and the channeled tRNA-cycle on ribosomes. ..
  83. Stehling O, Vashisht A, Mascarenhas J, Jonsson Z, Sharma T, Netz D, et al. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Science. 2012;337:195-9 pubmed publisher
    ..The function of MMS19 in the maturation of crucial components of DNA metabolism may explain the sensitivity of MMS19 mutants to DNA damage and the presence of extended telomeres. ..
  84. Gimpel M, Preis H, Barth E, Gramzow L, Brantl S. SR1--a small RNA with two remarkably conserved functions. Nucleic Acids Res. 2012;40:11659-72 pubmed publisher
    ..In vitro binding assays with six SR1/ahrC pairs suggest that-despite divergent primary sequences-the base-pairing function is also preserved. In summary, SR1 is an sRNA with two functions that have been conserved over ?1 billion years. ..
  85. Naumann M, Pirker W, Reiners K, Lange K, Becker G, Brucke T. Imaging the pre- and postsynaptic side of striatal dopaminergic synapses in idiopathic cervical dystonia: a SPECT study using [123I] epidepride and [123I] beta-CIT. Mov Disord. 1998;13:319-23 pubmed
  86. Zürcher H, Van Vooren P, Szpirer J, Szpirer C, Kreutz R. Assignment of the gene encoding renin binding protein (Renbp) to rat chromosome Xq37 by in situ hybridization and radiation hybrid mapping. Cytogenet Genome Res. 2002;97:277H pubmed
  87. Mayes M, Bossini Castillo L, Gorlova O, Martin J, Zhou X, Chen W, et al. Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. Am J Hum Genet. 2014;94:47-61 pubmed publisher
  88. Nix M, Stoffel W. Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation. Cell Death Differ. 2000;7:413-24 pubmed
    ..Reduced MAPK activity-dependent FLICE-like inhibitory protein (FLIP) expression in asmase-/- T lymphocytes increases their sensitivity towards Fas-mediated apoptosis. ..
  89. Wang Y, Marion Schneider E, Li X, Duttenhöfer I, Debatin K, Hug H. HIPK2 associates with RanBPM. Biochem Biophys Res Commun. 2002;297:148-53 pubmed
    ..Overexpressed wildtype RanBPM and a kinase defective mutant of HIPK2 co-localise with HIPK2 in defined nuclear structures. A carboxy- and an amino-terminal deletion of HIPK2 do not seem to be able to bind to RanBPM. ..
  90. Ramalingam N, Zhao H, Breitsprecher D, Lappalainen P, Faix J, Schleicher M. Phospholipids regulate localization and activity of mDia1 formin. Eur J Cell Biol. 2010;89:723-32 pubmed publisher
    ..Our data suggest that the N-terminal phospholipid-binding sites help to anchor formins at the plasma membrane, and the interaction with phospholipids in the C-terminus functions as a switch for transient inactivation. ..
  91. Sprunck S, Rademacher S, Vogler F, Gheyselinck J, Grossniklaus U, Dresselhaus T. Egg cell-secreted EC1 triggers sperm cell activation during double fertilization. Science. 2012;338:1093-7 pubmed publisher
    ..Our findings provide evidence that mutual gamete activation, regulated exocytosis, and sperm plasma membrane modifications govern flowering plant gamete interactions. ..
  92. Keller S, Nickel J, Zhang J, Sebald W, Mueller T. Molecular recognition of BMP-2 and BMP receptor IA. Nat Struct Mol Biol. 2004;11:481-8 pubmed
    ..Thus, the L51P substitution converts BMP-2 into a receptor-inactive inhibitor of noggin. These results are relevant for other proteins of the TGF-beta superfamily and provide useful clues for structure-based drug design. ..