Experts and Doctors on carrier proteins in Australia


Locale: Australia
Topic: carrier proteins

Top Publications

  1. Anggono V, Smillie K, Graham M, Valova V, Cousin M, Robinson P. Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Nat Neurosci. 2006;9:752-60 pubmed
    ..Thus syndapin I is a central component of the endocytic protein complex for SVE via stimulus-dependent recruitment to dynamin I and has a key role in synaptic transmission. ..
  2. Alm R, Manning P. Characterization of the hlyB gene and its role in the production of the El Tor haemolysin of Vibrio cholerae O1. Mol Microbiol. 1990;4:413-25 pubmed
    ..Nucleotide sequence analysis and cell fractionations reveal HlyB to be a 60.3 kD putative outer membrane-associated protein. ..
  3. Quinn J, Elliott J, Gillespie M, Martin T. A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro. Endocrinology. 1998;139:4424-7 pubmed
    ..We propose that this methodology can be employed to investigate the direct effects of cytokines and other factors on human osteoclast differentiation. ..
  4. Henderson B. Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover. Nat Cell Biol. 2000;2:653-60 pubmed
    ..These findings suggest that wild-type APC controls the nuclear accumulation of beta-catenin by a combination of nuclear export and cytoplasmic degradation. ..
  5. Petris M, Strausak D, Mercer J. The Menkes copper transporter is required for the activation of tyrosinase. Hum Mol Genet. 2000;9:2845-51 pubmed
    ..This study also contributes to our understanding of the molecular basis of pigmentation in mammalian cells...
  6. Rodriguez J, Au W, Henderson B. Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain. Exp Cell Res. 2004;293:14-21 pubmed
    ..We propose that BRCT mutations alter nuclear targeting of BRCA1, and that this may contribute to the inhibition of nuclear DNA repair and transcription function. ..
  7. Oakley C, Hambly B, Curmi P, Brown L. Myosin binding protein C: structural abnormalities in familial hypertrophic cardiomyopathy. Cell Res. 2004;14:95-110 pubmed
    ..This review looks at the current literature, in concert with alignments and the structural models of MyBPC, in an attempt to understand how FHC mutations may lead to the disease state. ..
  8. Schwab S, Wildenauer D. Update on key previously proposed candidate genes for schizophrenia. Curr Opin Psychiatry. 2009;22:147-53 pubmed publisher
  9. Yeoh S, Baxter R. Metabolic regulation of the growth hormone independent insulin-like growth factor binding protein in human plasma. Acta Endocrinol (Copenh). 1988;119:465-73 pubmed
    ..We conclude that BP-28 levels in adults are metabolically regulated, and postulate a role for this protein in the maintenance of glucose homeostasis. ..

More Information

Publications109 found, 100 shown here

  1. Smith F, Rae A, Hawkesford M. Molecular mechanisms of phosphate and sulphate transport in plants. Biochim Biophys Acta. 2000;1465:236-45 pubmed
    ..These data, together with functional characterisation of the transporters, are enabling the roles of various transporters in the overall phosphate and sulphate nutrition of plants to be defined. ..
  2. Scarlett C, O Leary M, Kee A, Nielsen A, Sevette A, Baxter R, et al. A study of parenteral versus enteral nutrition following caecal ligation and puncture in the rat: Influence on survival and tissue protein turnover. Clin Nutr. 2004;23:1135-45 pubmed
    ..In this model of severe abdominal sepsis where gut function cannot be assessed, enteral nutrition was associated with increased mortality and was less effective than parenteral nutrition in augmenting muscle and liver protein synthesis. ..
  3. Chayakulkeeree M, Johnston S, Oei J, Lev S, WILLIAMSON P, Wilson C, et al. SEC14 is a specific requirement for secretion of phospholipase B1 and pathogenicity of Cryptococcus neoformans. Mol Microbiol. 2011;80:1088-101 pubmed publisher
    ..neoformans preferentially exports virulence determinants to the cell periphery via distinct pathways. We also demonstrate that CnPlb1 secretion is essential for vomocytosis. ..
  4. Colebatch A, Hitchins M, Williams R, Meagher A, Hawkins N, Ward R. The role of MYH and microsatellite instability in the development of sporadic colorectal cancer. Br J Cancer. 2006;95:1239-43 pubmed
    ..Tumours arising in the setting of BER or mismatch repair deficiency may share a biological characteristic, which promotes lymphocytic infiltration. ..
  5. Harris M, Kuwano M, Webb M, Board P. Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/MOAT). J Biol Chem. 2001;276:20876-81 pubmed
    ..Increased transport of 2,4-dinitrophenyl glutathione from L1210 cells expressing DeltaMRP2 showed that the re-targeted protein retains its normal function. ..
  6. Mills K, Brocardo M, Henderson B. APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane. Mol Biol Cell. 2016;27:466-82 pubmed publisher
    ..We propose that APC helps drive mitochondria to the membrane to supply energy for cellular processes such as directed cell migration, a process disrupted by cancer mutations. ..
  7. Smith F, Hawkesford M, Prosser I, Clarkson D. Isolation of a cDNA from Saccharomyces cerevisiae that encodes a high affinity sulphate transporter at the plasma membrane. Mol Gen Genet. 1995;247:709-15 pubmed
    ..We conclude that the SUL1 cDNA encodes a S. cerevisiae high affinity sulphate transporter that is responsible for the transfer of sulphate across the plasma membrane from the external medium. ..
  8. Eriköz B, Jusuf P, Percival K, Grünert U. Distribution of bipolar input to midget and parasol ganglion cells in marmoset retina. Vis Neurosci. 2008;25:67-76 pubmed publisher
    ..Our findings suggest that the differences in the response characteristics of midget and parasol cells are not due to differences in the density of synaptic input to their dendritic tree. ..
  9. Nasr N, Alshehri A, Wright T, Shahid M, Heiner B, Harman A, et al. Mechanism of Interferon-Stimulated Gene Induction in HIV-1-Infected Macrophages. J Virol. 2017;91: pubmed publisher
    ..These antiviral ISGs may contribute to persistent infection in macrophages and to the establishment of viral reservoirs in vivo. ..
  10. Delhanty P, Baxter R. Cloning and characterization of the rat gene for the acid-labile subunit of the insulin-like growth factor binding protein complex. J Mol Endocrinol. 1997;19:267-77 pubmed
    ..Our data demonstrate the uncomplicated structure of the rat ALS gene, and the promoter function and presence of potential regulatory elements in the region upstream of the protein-coding sequence. ..
  11. Leaver K, Reynolds A, Bodard S, Guilloteau D, Chalon S, Kassiou M. Effects of translocator protein (18 kDa) ligands on microglial activation and neuronal death in the quinolinic-acid-injected rat striatum. ACS Chem Neurosci. 2012;3:114-9 pubmed publisher
    ..All of the ligands decreased microglial activation following the injection of QUIN but had no effect on astrogliosis. Interestingly, we also observed neuroprotective effects from the vehicle, dimethyl sulfoxide (DMSO). ..
  12. Townson S, Lagercrantz J, Grimmond S, Silins G, Nordenskjold M, Weber G, et al. Characterization of the murine VEGF-related factor gene. Biochem Biophys Res Commun. 1996;220:922-8 pubmed
    ..A short polymorphic AC repeat is present in the 3' untranslated region of murine vrf. A major band of approximately 1.3kb was expressed in all adult mouse tissues examined. ..
  13. Silins G, Grimmond S, Egerton M, Hayward N. Analysis of the promoter region of the human VEGF-related factor gene. Biochem Biophys Res Commun. 1997;230:413-8 pubmed
    ..These data may indicate that expression of these two growth factors is regulated by different physiological stimuli. ..
  14. Rodriguez J, Schüchner S, Au W, Fabbro M, Henderson B. Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1. Oncogene. 2004;23:1809-20 pubmed
    ..Our findings suggest that BRCA1/BARD1 heterodimer formation is important for optimal nuclear targeting of BARD1 and its role in DNA repair and cell survival. ..
  15. Mok M, Henderson B. The in vivo dynamic organization of BRCA1-A complex proteins at DNA damage-induced nuclear foci. Traffic. 2012;13:800-14 pubmed publisher
  16. Zhou G, Delhaize E, Zhou M, Ryan P. The barley MATE gene, HvAACT1, increases citrate efflux and Al(3+) tolerance when expressed in wheat and barley. Ann Bot. 2013;112:603-12 pubmed publisher
    ..The aim of this study was to investigate whether expressing HvAACT1 with a constitutive promoter in barley and wheat can increase citrate efflux and Al(3+) tolerance of these important cereal species...
  17. Nadvi N, Michie K, Kwan A, Guss J, Trewhella J. Clinically Linked Mutations in the Central Domains of Cardiac Myosin-Binding Protein C with Distinct Phenotypes Show Differential Structural Effects. Structure. 2016;24:105-115 pubmed publisher
    ..The results are discussed in terms of understanding key structural features of these domains essential for healthy function and the role they may play in disease development. ..
  18. Paulsen I, Skurray R, Tam R, Saier M, Turner R, Weiner J, et al. The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Mol Microbiol. 1996;19:1167-75 pubmed
    ..The roles of specific residues, a possible mechanistic model of drug efflux, and the primary physiological role(s) of the SMR proteins are discussed. ..
  19. Doggrell S. The role of 5-HT on the cardiovascular and renal systems and the clinical potential of 5-HT modulation. Expert Opin Investig Drugs. 2003;12:805-23 pubmed
    ..In hypertension, agonists at the 5-HT(7) and antagonists at the 5-HT(2B) may reduce blood pressure, and in diabetes, sarpogrelate may protect against nephropathy. ..
  20. Tangye S, van de Weerdt B, Avery D, Hodgkin P. CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. Eur J Immunol. 2002;32:1640-9 pubmed
    ..Thus, investigation of expression and function of CD84 and CD27 is likely to contribute to a greater understanding of the development and biology of memory B cells in normal and immunocompromised hosts. ..
  21. Holmgreen S, Huang D, Adams J, Cory S. Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members. Cell Death Differ. 1999;6:525-32 pubmed
    ..The results may reflect critical threshold affinities but also suggest that certain pro-apoptotic proteins may also contribute to apoptosis by a mechanism independent of binding pro-survival proteins. ..
  22. Gedeon A, Colley A, Jamieson R, Thompson E, Rogers J, Sillence D, et al. Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda. Nat Genet. 1999;22:400-4 pubmed
    ..The gene designated SEDL is transcribed as a 2.8-kb transcript in many tissues including fetal cartilage. SEDL encodes a 140 amino acid protein with a putative role in endoplasmic reticulum (ER)-to-Golgi vesicular transport. ..
  23. Steer A, Law I, Matatolu L, Beall B, Carapetis J. Global emm type distribution of group A streptococci: systematic review and implications for vaccine development. Lancet Infect Dis. 2009;9:611-6 pubmed publisher
  24. Sadeghipour S, Bek E, McMinn P. Selection and characterisation of guanidine-resistant mutants of human enterovirus 71. Virus Res. 2012;169:72-9 pubmed publisher
    ..This study confirms that guanidine resistance can be readily selected in HEV71 and is attributable to mutations within protein 2C. ..
  25. Kuang L, Colgrave M, Bagnall N, Knox M, Qian M, Wijffels G. The complexity of the secreted NPA and FAR lipid-binding protein families of Haemonchus contortus revealed by an iterative proteomics-bioinformatics approach. Mol Biochem Parasitol. 2009;168:84-94 pubmed publisher
    ..We predict there are at least one Hc-NPA gene and six Hc-FAR genes in H. contortus, and life stage gene expression of Hc-FAR-1 to -6 revealed unique transcription patterns for each of these genes. ..
  26. Karupiah G, Hunt N, King N, Chaudhri G. NADPH oxidase, Nramp1 and nitric oxide synthase 2 in the host antimicrobial response. Rev Immunogenet. 2000;2:387-415 pubmed
    ..It is the critical balance of these processes in the initial stages of infection that determines the outcome of infectious disease. ..
  27. Gregorio King C, Collier G, McMillan J, Waugh C, McLeod J, Collier F, et al. ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells. Blood. 2001;98:2279-81 pubmed
    ..Characterization and differential expression of ORP-3 implicates a possible role in the mediation of oxysterol effects on hematopoiesis. ..
  28. Blair J, Zhou H, Seibel M, Dunstan C. Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Nat Clin Pract Oncol. 2006;3:41-9 pubmed
    ..This review summarizes the current evidence of osteoprotegerin, RANK ligand and RANK involvement in the pathophysiology of skeletal metastasis, and of therapeutic targeting of this process. ..
  29. Shashkov A, Kenyon J, Senchenkova S, Shneider M, Popova A, Arbatsky N, et al. Acinetobacter baumannii K27 and K44 capsular polysaccharides have the same K unit but different structures due to the presence of distinct wzy genes in otherwise closely related K gene clusters. Glycobiology. 2016;26:501-8 pubmed publisher
    ..This may affect its capacity as a protective barrier for A. baumannii. ..
  30. Luo L, Xue J, Kwan A, Gamsjaeger R, Wielens J, von Kleist L, et al. The Binding of Syndapin SH3 Domain to Dynamin Proline-rich Domain Involves Short and Long Distance Elements. J Biol Chem. 2016;291:9411-24 pubmed publisher
    ..To our knowledge this is the first example among known SH3 interactions to involve spatially separated and extended long-range elements that combine to provide a higher affinity interaction. ..
  31. Whitten A, Jeffries C, Harris S, Trewhella J. Cardiac myosin-binding protein C decorates F-actin: implications for cardiac function. Proc Natl Acad Sci U S A. 2008;105:18360-5 pubmed publisher
    ..Direct interactions between the N terminus of cMyBP-C and actin thereby provide a mechanism to modulate the contractile cycle by affecting the regulatory state of the thin filament and its ability to interact with myosin. ..
  32. Abu Siniyeh A, Owen D, Benzing C, Rinkwitz S, Becker T, Majumdar A, et al. The aPKC/Par3/Par6 Polarity Complex and Membrane Order Are Functionally Interdependent in Epithelia During Vertebrate Organogenesis. Traffic. 2016;17:66-79 pubmed publisher
    ..Hence our data suggest that the biophysical property of membrane lipid packing is a regulatory element in apical basal polarity. ..
  33. Hardy C, Clarke H, Nixon B, Grigg J, Hinds L, Holland M. Examination of the immunocontraceptive potential of recombinant rabbit fertilin subunits in rabbit. Biol Reprod. 1997;57:879-86 pubmed
    ..Only one animal subsequently showed impaired fertility. These results show that in the rabbit, high levels of circulating sperm-reactive anti-fertilin antibodies and the presence of vaginal IgG does not ensure infertility. ..
  34. Melrose J, Ghosh P, Taylor T. A comparative analysis of the differential spatial and temporal distributions of the large (aggrecan, versican) and small (decorin, biglycan, fibromodulin) proteoglycans of the intervertebral disc. J Anat. 2001;198:3-15 pubmed
  35. Chen L, Willis S, Wei A, Smith B, Fletcher J, Hinds M, et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005;17:393-403 pubmed
    ..The results suggest that apoptosis relies on selective interactions between particular subsets of these proteins and that it should be feasible to discover BH3-mimetic drugs that inactivate specific prosurvival targets. ..
  36. Gardiner J, Barton D, Vanslambrouck J, Braet F, Hall D, Marc J, et al. Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases. Neuroscientist. 2008;14:240-50 pubmed publisher
    ..Here we show that the protein involved in familial dysautonomia, IKAP, localizes to keratin filaments in HeLa cells, suggesting a role for the keratin cytoskeleton in neurotrophic support. ..
  37. Lu Y, Kwan A, Trewhella J, Jeffries C. The C0C1 fragment of human cardiac myosin binding protein C has common binding determinants for both actin and myosin. J Mol Biol. 2011;413:908-13 pubmed publisher
    ..Our results suggest that C0 and C1 interact with myosin and actin using a common set of binding determinants and therefore support a cMyBP-C switching mechanism between myosin and actin. ..
  38. Wang K, Zhu X, Zhang K, Yao Y, Zhuang M, Tan C, et al. Puerarin inhibits amyloid ?-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses. Exp Cell Res. 2017;357:335-340 pubmed publisher
    ..Therefore, the significance of the current study is to reveal the novel mechanism of puerarin in the prevention of AMD. ..
  39. Ali S, Bassett J. The release of corticosterone and a corticosterone-binding protein by incubated rat adrenal slices. J Steroid Biochem Mol Biol. 1991;39:119-29 pubmed
    ..It is possible that the adrenal protein may be CBG that has been internalized, modified and released with corticosterone. ..
  40. Smith F, Ealing P, Dong B, Delhaize E. The cloning of two Arabidopsis genes belonging to a phosphate transporter family. Plant J. 1997;11:83-92 pubmed
    ..The APT1 and APT2 polypeptides are likely to be associated with the membrane transport of phosphate within A. thaliana roots. ..
  41. Kaiser B, Finnegan P, Tyerman S, Whitehead L, Bergersen F, Day D, et al. Characterization of an ammonium transport protein from the peribacteroid membrane of soybean nodules. Science. 1998;281:1202-6 pubmed
    ..GmSAT1 is likely to be involved in the transfer of fixed nitrogen from the bacteroid to the host...
  42. Kowalski K, Czolij R, King G, Crossley M, Mackay J. The solution structure of the N-terminal zinc finger of GATA-1 reveals a specific binding face for the transcriptional co-factor FOG. J Biomol NMR. 1999;13:249-62 pubmed
  43. Mark P, Ward B, Kumar P, Lahooti H, Minchin R, Ratajczak T. Human cyclophilin 40 is a heat shock protein that exhibits altered intracellular localization following heat shock. Cell Stress Chaperones. 2001;6:59-70 pubmed
    ..Under normal growth conditions, MCF-7 cells exhibited an apparent colocalization of CyP40 and FKBP52 within the nucleolus. ..
  44. Brown L, Singh L, Sale K, Yu B, Trent R, Fajer P, et al. Functional and spectroscopic studies of a familial hypertrophic cardiomyopathy mutation in Motif X of cardiac myosin binding protein-C. Eur Biophys J. 2002;31:400-8 pubmed
    ..Taken together, these data suggest that the Motif X mutation may interfere with other, as yet unidentified, functional interactions. ..
  45. Anniss A, Apostolopoulos J, Dworkin S, Purton L, Sparrow R. An oxysterol-binding protein family identified in the mouse. DNA Cell Biol. 2002;21:571-80 pubmed
    ..The identification of a family of ORP proteins in the mouse, the frequently preferred animal model for in vivo studies, should further our understanding of the function of these proteins and their interactions with each other. ..
  46. Perdomo J, Crossley M. The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. Eur J Biochem. 2002;269:5885-92 pubmed
    ..We conclude that several Ikaros family proteins utilize CtBP corepressors to inhibit gene expression. ..
  47. Kerr M, Lindsay M, Luetterforst R, Hamilton N, Simpson F, Parton R, et al. Visualisation of macropinosome maturation by the recruitment of sorting nexins. J Cell Sci. 2006;119:3967-80 pubmed
    ..Collectively these findings provide a detailed real-time characterisation of the maturation process of the macropinocytic endosome. ..
  48. Kockx M, Guo D, Huby T, Lesnik P, Kay J, Sabaretnam T, et al. Secretion of apolipoprotein E from macrophages occurs via a protein kinase A and calcium-dependent pathway along the microtubule network. Circ Res. 2007;101:607-16 pubmed
    ..We conclude that macrophage secretion of apoE occurs via a PKA- and calcium-dependent pathway along the microtubule network. ..
  49. Proudfoot J, Barden A, Loke W, Croft K, Puddey I, Mori T. HDL is the major lipoprotein carrier of plasma F2-isoprostanes. J Lipid Res. 2009;50:716-22 pubmed publisher
    ..Further studies are required to establish the implications of these findings on HDL function. ..
  50. Couchman K, Garrett A, Deardorff A, Rattay F, Resatz S, Fyffe R, et al. Lateral superior olive function in congenital deafness. Hear Res. 2011;277:163-75 pubmed publisher
    ..This could have clinical repercussions on the development of stimulation paradigms for spatial hearing with cochlear implants. ..
  51. Shi W, Bain A, Schwer B, Al Ejeh F, Smith C, Wong L, et al. Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet. 2013;9:e1003298 pubmed publisher
    ..Collectively, these results demonstrate essential roles of Ssb1 in embryogenesis, spermatogenesis, and genome stability in vivo. ..
  52. Goh C, Putz U, Howitt J, Low L, Gunnersen J, Bye N, et al. Nuclear trafficking of Pten after brain injury leads to neuron survival not death. Exp Neurol. 2014;252:37-46 pubmed publisher
    ..We conclude that nuclear trafficking of Pten following injury leads to neuron survival not death. ..
  53. Huang C, Lin M, Cheng D, Braet F, Pollock C, Chen X. Thioredoxin-interacting protein mediates dysfunction of tubular autophagy in diabetic kidneys through inhibiting autophagic flux. Lab Invest. 2014;94:309-20 pubmed publisher
    ..HG-induced overexpression of TXNIP may contribute to the dysfunction of tubular autophagy in diabetes. ..
  54. Lemckert F, Bournazos A, Eckert D, Kenzler M, Hawkes J, Butler T, et al. Lack of MG53 in human heart precludes utility as a biomarker of myocardial injury or endogenous cardioprotective factor. Cardiovasc Res. 2016;110:178-87 pubmed publisher
    ..Although cardioprotective roles for endogenous myocardial MG53 cannot be extrapolated from rodents to humans, potential therapeutic application of recombinant MG53 for myocardial membrane injury prevails. ..
  55. Wallace B, Yang Y, Hong J, Lum D. Cloning and sequencing of a gene encoding a glutamate and aspartate carrier of Escherichia coli K-12. J Bacteriol. 1990;172:3214-20 pubmed
    ..These results suggest that gltP is a structural gene for a carrier protein of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system. ..
  56. MacPherson K, Xu Y, Cheah E, Carr P, van Heeswijk W, Westerhoff H, et al. Crystallization and preliminary X-ray analysis of Escherichia coli GlnK. Acta Crystallogr D Biol Crystallogr. 1998;54:996-8 pubmed
    ..45 and c = 54.79 A. These crystals have a single subunit in the asymmetric unit. High-quality diffraction data from crystals of GlnK and the GlnK complex have been collected to 2.0 A. ..
  57. Mahalingam S, Karupiah G. Chemokines and chemokine receptors in infectious diseases. Immunol Cell Biol. 1999;77:469-75 pubmed
    ..In this regard, the chemokines and their receptors are a major target. Reviewed in the present paper are several examples in which microbial pathogens have usurped the mammalian chemokine system to subvert the host immune response. ..
  58. Kumar R, Neilsen P, Crawford J, McKirdy R, Lee J, Powell J, et al. FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. Cancer Res. 2005;65:11304-13 pubmed
    ..We propose that FBXO31 functions as a tumor suppressor by generating SCF(FBXO31) complexes that target particular substrates, critical for the normal execution of the cell cycle, for ubiquitination and subsequent degradation. ..
  59. Jeffries C, Whitten A, Harris S, Trewhella J. Small-angle X-ray scattering reveals the N-terminal domain organization of cardiac myosin binding protein C. J Mol Biol. 2008;377:1186-99 pubmed publisher
  60. Dinger M, Amaral P, Mercer T, Pang K, Bruce S, Gardiner B, et al. Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Res. 2008;18:1433-45 pubmed publisher
    ..Taken together, our data indicate that long ncRNAs are likely to be important in processes directing pluripotency and alternative differentiation programs, in some cases through engagement of the epigenetic machinery. ..
  61. Sharma S, Koh K, Collin C, Dave A, McMellon A, Sugiyama Y, et al. NHS-A isoform of the NHS gene is a novel interactor of ZO-1. Exp Cell Res. 2009;315:2358-72 pubmed publisher
    ..In conclusion, the NHS-A isoform of NHS is a novel interactor of ZO-1 and may have a role at tight junctions. This isoform is important in mammalian development especially of the organs in the head. ..
  62. Qi W, Chen X, Holian J, Tan C, Kelly D, Pollock C. Transcription factors Krüppel-like factor 6 and peroxisome proliferator-activated receptor-{gamma} mediate high glucose-induced thioredoxin-interacting protein. Am J Pathol. 2009;175:1858-67 pubmed publisher
    ..Hence, Txnip expression and promoter activity are mediated via divergent effects of KLF6 and PPAR-gamma transcriptional regulation. ..
  63. Connor M, Vaughan C, Vandenberg R. N-acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets. Br J Pharmacol. 2010;160:1857-71 pubmed publisher
    ..Investigation of the physiological roles and pharmacological potential of these simple lipid conjugates is in its infancy, and we believe that there is much to be learnt from their careful study. ..
  64. Stokes P, Liew C, Kwan A, Foo P, Barker H, Djamirze A, et al. Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8. J Mol Biol. 2013;425:1101-10 pubmed publisher
    ..We hypothesise that overexpression of LMO4 may disrupt some of the normal tumour suppressor activities of CtIP, thereby contributing to breast cancer progression. ..
  65. Dai J, Baxter R. Molecular cloning of the acid-labile subunit of the rat insulin-like growth factor binding protein complex. Biochem Biophys Res Commun. 1992;188:304-9 pubmed
    ..4 kb and minor bands of about 2 kb, 1.4 kb and 1 kb. The tissue distribution of this protein may therefore be wider than previously recognized. ..
  66. Paulsen I, Skurray R. The POT family of transport proteins. Trends Biochem Sci. 1994;19:404 pubmed
  67. Chapman Smith A, Turner D, Cronan J, Morris T, Wallace J. Expression, biotinylation and purification of a biotin-domain peptide from the biotin carboxy carrier protein of Escherichia coli acetyl-CoA carboxylase. Biochem J. 1994;302 ( Pt 3):881-7 pubmed
    ..The identify of the purified biotin-domain peptide was confirmed by N-terminal sequence analysis, amino acid analysis and m.s. The domain was readily produced and purified in sufficient quantities for n.m.r. structural analysis. ..
  68. Hannan A, Henke R, Weinberger R, Sentry J, Jeffrey P. Differential induction and intracellular localization of SCG10 messenger RNA is associated with neuronal differentiation. Neuroscience. 1996;72:889-900 pubmed
    ..The directed transport and positional translation of SCG10 messenger RNA provide a potential mechanism for protein targeting and the creation of molecular compartments during neuronal differentiation. ..
  69. Chaturapanich G, Ishibashi H, Dinudom A, Young J, Cook D. H+ transporters in the main excretory duct of the mouse mandibular salivary gland. J Physiol. 1997;503 ( Pt 3):583-98 pubmed
    ..The difference is in concordance with the known ability of the mandibular gland of the rat, but not the rabbit or the mouse, to secrete a HCO3(-)-rich final saliva. ..
  70. Brown L, Yin J, Hambly B. Direct cloning of polymerase chain reaction products into the pinpoint Xa1-T vector protein expression system. Electrophoresis. 1998;19:860-6 pubmed
    ..The Pinpoint vector proved to be a relatively simple and fast protein expression technique suitable for wide application for expressing recombinant proteins. ..
  71. Hubner S, Smith H, Hu W, Chan C, Rihs H, Paschal B, et al. Plant importin alpha binds nuclear localization sequences with high affinity and can mediate nuclear import independent of importin beta. J Biol Chem. 1999;274:22610-7 pubmed
    ..At-IMPalpha's novel NLS recognition and nuclear transport properties imply that plants may possess an IMPalpha-mediated nuclear import pathway independent of IMPbeta in addition to that mediated by IMPalpha/beta. ..
  72. Liu X, Baker E, Eyre H, Sutherland G, Zhou M. Gamma-heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation. Oncogene. 1999;18:7110-4 pubmed
    ..We conclude, therefore, that gamma-heregulin is not a native isoform of the neuregulin-1 gene, but a novel growth factor that may contribute to tumour cell proliferation. ..
  73. Matthews J, Kowalski K, Liew C, Sharpe B, Fox A, Crossley M, et al. A class of zinc fingers involved in protein-protein interactions biophysical characterization of CCHC fingers from fog and U-shaped. Eur J Biochem. 2000;267:1030-8 pubmed
  74. Xu J, Tan J, Huang L, Gao X, Laird R, Liu D, et al. Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand. J Bone Miner Res. 2000;15:2178-86 pubmed
  75. O Leary M, Quinton N, Ferguson C, Preedy V, Ross R, Hinds C. In rats with sepsis, the acute fall in IGF-I is associated with an increase in circulating growth hormone-binding protein levels. Intensive Care Med. 2000;26:1547-52 pubmed
    ..Reduced IGF-I levels in sepsis in the rat are associated with elevations in GHBP and a trend to increased hepatic GH binding. This suggests that in sepsis 'GH resistance' is not associated with reduced GH receptor numbers. ..
  76. Shi B, Palukaitis P, Symons R. Differential virulence by strains of Cucumber mosaic virus is mediated by the 2b gene. Mol Plant Microbe Interact. 2002;15:947-55 pubmed
  77. Diefenbach R, Diefenbach E, Douglas M, Cunningham A. The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23. Biochemistry. 2002;41:14906-15 pubmed
    ..In support of separate binding sites on heavy chain for light chain and SNAPs, a complex of heavy and light chains was observed to interact with SNAP25 and SNAP23. ..
  78. Al Mahdili H, Hooper A, Sullivan D, Stewart P, Burnett J. A mild case of abetalipoproteinaemia in association with subclinical hypothyroidism. Ann Clin Biochem. 2006;43:516-9 pubmed
    ..61 + 2T > C) and a single adenine insertion in MTP exon 4 (c.419-420insA) that results in a frameshift and a protein truncated at 140 amino acids...
  79. Hamidian M, Hall R. AbaR4 replaces AbaR3 in a carbapenem-resistant Acinetobacter baumannii isolate belonging to global clone 1 from an Australian hospital. J Antimicrob Chemother. 2011;66:2484-91 pubmed publisher
    ..To explore the diversity of genomic resistance islands in multiply antibiotic-resistant Acinetobacter baumannii isolates in global clone 1 (GC1) from Australian hospitals...
  80. Dworkin S, Darido C, Georgy S, Wilanowski T, Srivastava S, Ellett F, et al. Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways. Development. 2012;139:525-36 pubmed publisher
    ..Collectively, these data show that MHB maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets. ..
  81. Seebacher F, Walter I. Differences in locomotor performance between individuals: importance of parvalbumin, calcium handling and metabolism. J Exp Biol. 2012;215:663-70 pubmed publisher
    ..We provide mechanistic explanations of why locomotor performance differs between individuals, which is important for understanding ecological and sporting success, disease and the evolutionary processes underlying selection. ..
  82. Cox T, Bawden M, Martin A, May B. Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA. EMBO J. 1991;10:1891-902 pubmed
    ..These results suggest that the IRE motif in the ALAS mRNA is functional and imply that translation of the mRNA is controlled by cellular iron availability during erythropoiesis. ..
  83. Rowland S, Errington J, Wake R. The Bacillus subtilis cell-division 135-137 degrees region contains an essential orf with significant similarity to murB and a dispensable sbp gene. Gene. 1995;164:113-6 pubmed
    ..A small gene found in the same region as orf2, sbp (encoding the 'small basic protein'), was shown to be non-essential in Bs. ..
  84. Ewart G, Cannell D, Cox G, Howells A. Mutational analysis of the traffic ATPase (ABC) transporters involved in uptake of eye pigment precursors in Drosophila melanogaster. Implications for structure-function relationships. J Biol Chem. 1994;269:10370-7 pubmed
    ..The implications of these mutations are discussed in terms of a model of the Drosophila pigment precursor transport system. ..
  85. Ross I, Dunn T, Yue X, Roy S, Barnett C, Hume D. Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes. Oncogene. 1994;9:121-32 pubmed
    ..1 expression. The data suggest that differences in nuclear PU.1 expression and function between macrophages and B cells may play a role in lineage divergence. ..
  86. Harrison M, Dameron C. Molecular mechanisms of copper metabolism and the role of the Menkes disease protein. J Biochem Mol Toxicol. 1999;13:93-106 pubmed
    ..This forms the basis for a discussion of Menkes disease and the protein deficit in this disease. ..
  87. Waterhouse N, Finucane D, Green D, Elce J, Kumar S, Alnemri E, et al. Calpain activation is upstream of caspases in radiation-induced apoptosis. Cell Death Differ. 1998;5:1051-61 pubmed
    ..These results support a role for calpain in the early phases of the radiation-induced apoptosis pathway, upstream of the caspases. ..
  88. Webb D, Cripps A. Immunization with recombinant transferrin binding protein B enhances clearance of nontypeable Haemophilus influenzae from the rat lung. Infect Immun. 1999;67:2138-44 pubmed
  89. Supple S, Iland H, Barnett M, Pollard J. A spontaneous novel XK gene mutation in a patient with McLeod syndrome. Br J Haematol. 2001;115:369-72 pubmed
    ..The mutation was not identified in the patient's mother or sister indicating that this mutation was spontaneous. ..
  90. McLaughlin E, Holland M, Aitken R. Contraceptive vaccines. Expert Opin Biol Ther. 2003;3:829-41 pubmed
  91. Henshall S, Afar D, Rasiah K, Horvath L, Gish K, Caras I, et al. Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer. Oncogene. 2003;22:6005-12 pubmed
    ..These findings are consistent with a role for ZnT4 in vesicular transport of zinc to the cell membrane and potentially in efflux of zinc in the prostate. ..
  92. Simpson R, Yi Lee S, Bartle N, Sum E, Visvader J, Matthews J, et al. A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3. J Biol Chem. 2004;279:39789-97 pubmed
    ..Our data demonstrate the versatility of cZFs and have implications for the analysis of many as yet uncharacterized cZF proteins. ..