Experts and Doctors on carbohydrate sequence in Canada


Locale: Canada
Topic: carbohydrate sequence

Top Publications

  1. MacLean L, Perry M, Chen W, Vinogradov E. The structure of the polysaccharide O-chain of the LPS from Acinetobacter baumannii strain ATCC 17961. Carbohydr Res. 2009;344:474-8 pubmed publisher
  2. Calinescu C, Mondovi B, Federico R, Ispas Szabo P, Mateescu M. Carboxymethyl starch: Chitosan monolithic matrices containing diamine oxidase and catalase for intestinal delivery. Int J Pharm. 2012;428:48-56 pubmed publisher
    ..The proposed formulations could allow novel therapeutic approaches for the treatment of inflammatory bowel diseases, intestinal cancers or pseudo-allergic reactions. ..
  3. Schachter H. The joys of HexNAc. The synthesis and function of N- and O-glycan branches. Glycoconj J. 2000;17:465-83 pubmed
    ..7) The crystal structure of N-acetylglucosaminyltransferase I. (8) The discovery of the enzymes which synthesize O-glycan cores 1, 2, 3 and 4 and their elongation. ..
  4. McNally D, Jarrell H, Khieu N, Li J, Vinogradov E, Whitfield D, et al. The HS:19 serostrain of Campylobacter jejuni has a hyaluronic acid-type capsular polysaccharide with a nonstoichiometric sorbose branch and O-methyl phosphoramidate group. FEBS J. 2006;273:3975-89 pubmed
    ..The findings of this work with the HS:19 serostrain now present a means to explore the role of CPS as a virulence factor in C. jejuni. ..
  5. Vinogradov E, Wilde C, Anderson E, Nakhamchik A, Lam J, Rowe Magnus D. Structure of the lipopolysaccharide core of Vibrio vulnificus type strain 27562. Carbohydr Res. 2009;344:484-90 pubmed publisher
    ..Lipid A was analyzed for fatty acid composition and the following fatty acids were found: C14:0, C12:0-3OH, C16:0, C16:1, C14:0-3OH, C18:0, C18:1 in a ratio of 1:3:3:1:2.5:0.6:0.8. ..
  6. King J, Vinogradov E, Tran V, Lam J. Biosynthesis of uronamide sugars in Pseudomonas aeruginosa O6 and Escherichia coli O121 O antigens. Environ Microbiol. 2010;12:1531-44 pubmed publisher
    ..The E. coli O121 wbqG mutant O antigen contains 2-acetamido-2-deoxy-d-galacturonate (d-GalNAcA), instead of d-GalNAcAN, demonstrating that wbqG is specifically required for biosynthesis of the carboxamide in this sugar. ..
  7. Upasani V, Desai S, Moldoveanu N, Kates M. Lipids of extremely halophilic archaeobacteria from saline environments in India: a novel glycolipid in Natronobacterium strains. Microbiology. 1994;140 ( Pt 8):1959-66 pubmed
    ..Hydroxylated lipid cores have previously been identified only in some methanogenic archaeobacteria...
  8. Rocchetta H, Burrows L, Pacan J, Lam J. Three rhamnosyltransferases responsible for assembly of the A-band D-rhamnan polysaccharide in Pseudomonas aeruginosa: a fourth transferase, WbpL, is required for the initiation of both A-band and B-band lipopolysaccharide synthesis. Mol Microbiol. 1998;28:1103-19 pubmed
    ..These data indicate that A-band polysaccharide assembly requires four glycosyltransferases, one of which is necessary for initiating both A-band and B-band LPS synthesis. ..
  9. Brayer G, Sidhu G, Maurus R, Rydberg E, Braun C, Wang Y, et al. Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry. 2000;39:4778-91 pubmed
    ..Structural analyses of the Asp300Asn variant of human pancreatic alpha-amylase and its complex with acarbose clearly demonstrate the importance of Asp300 to the mode of inhibitor binding. ..

More Information


  1. Hung M, Xia Z, Hu N, Lee B. Molecular and biochemical analysis of two beta-galactosidases from Bifidobacterium infantis HL96. Appl Environ Microbiol. 2001;67:4256-63 pubmed
    ..The structure of the major trisaccharide produced by beta-GalI catalysis was characterized as O-beta-D-galactopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-4)-D-glucopyranose (3'-galactosyl-lactose)...
  2. Pelletier I, Hashidate T, Urashima T, Nishi N, Nakamura T, Futai M, et al. Specific recognition of Leishmania major poly-beta-galactosyl epitopes by galectin-9: possible implication of galectin-9 in interaction between L. major and host cells. J Biol Chem. 2003;278:22223-30 pubmed
    ..major and macrophages, suggesting distinctive roles for the galectins in the L. major-specific development of leishmaniasis in the host. ..
  3. Ramjeet M, Deslandes V, St Michael F, Cox A, Kobisch M, Gottschalk M, et al. Truncation of the lipopolysaccharide outer core affects susceptibility to antimicrobial peptides and virulence of Actinobacillus pleuropneumoniae serotype 1. J Biol Chem. 2005;280:39104-14 pubmed
    ..pleuropneumoniae against cationic peptides and that deletion of specific residues in the outer LPS core results in the attenuation of the virulence of A. pleuropneumoniae serotype 1...
  4. Rullo A, Papp Szabo E, Michael F, Macinnes J, Monteiro M. The structural basis for the serospecificity of Actinobacillus suis serogroup O:2. Biochem Cell Biol. 2006;84:184-90 pubmed
    ..suis serogroup O:2 strains is currently underway...
  5. Deutschmann R, Boncheff A, MacInnes J, Monteiro M. Discovery and characterization of a fructosylated capsule polysaccharide and sialylated lipopolysaccharide in a virulent strain of Actinobacillus suis. Biochem Cell Biol. 2011;89:325-31 pubmed publisher
  6. Ganeshapillai J, Boncheff A, Slavic D, Macinnes J, Monteiro M. The lipopolysaccharide core of Actinobacillus suis and its relationship to those of Actinobacillus pleuropneumoniae. Biochem Cell Biol. 2011;89:351-8 pubmed publisher
    ..suis and A. pleuropneumoniae, and the data suggest that the structural epitopes responsible for immunogenicity are those in the outer core domain...