Experts and Doctors on calmodulin in France


Locale: France
Topic: calmodulin

Top Publications

  1. Di Giovanni J, Iborra C, MAULET Y, Leveque C, El Far O, Seagar M. Calcium-dependent regulation of SNARE-mediated membrane fusion by calmodulin. J Biol Chem. 2010;285:23665-75 pubmed publisher
    ..Furthermore, synaptotagmin displaced calmodulin binding to target-SNAREs. These findings suggest that two distinct Ca(2+) sensors act antagonistically in SNARE-mediated fusion. ..
  2. Amelot N, Carrouche A, Danoun S, Bourque S, Haiech J, Pugin A, et al. Cryptogein, a fungal elicitor, remodels the phenylpropanoid metabolism of tobacco cell suspension cultures in a calcium-dependent manner. Plant Cell Environ. 2011;34:149-61 pubmed publisher
  3. Perochon A, Aldon D, Galaud J, Ranty B. Calmodulin and calmodulin-like proteins in plant calcium signaling. Biochimie. 2011;93:2048-53 pubmed publisher
    ..We discuss emerging paradigms in the field and highlight the areas that need further investigation. ..
  4. Karst J, Sotomayor Pérez A, Guijarro J, Raynal B, Chenal A, Ladant D. Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin. Biochemistry. 2010;49:318-28 pubmed publisher
    ..On the basis of these data, we propose a model for the structural transition between the calmodulin-free and calmodulin-bound AC. ..
  5. De Haro L, Quetglas S, Iborra C, Leveque C, Seagar M. Calmodulin-dependent regulation of a lipid binding domain in the v-SNARE synaptobrevin and its role in vesicular fusion. Biol Cell. 2003;95:459-64 pubmed
    ..Displacement of these interactions by Ca2+/calmodulin may promote SNARE complex assembly and lead to trans interactions between the membrane proximal region of VAMP and phospholipids in the plasma membrane. ..
  6. Charpenteau M, Jaworski K, Ramirez B, Tretyn A, Ranjeva R, Ranty B. A receptor-like kinase from Arabidopsis thaliana is a calmodulin-binding protein. Biochem J. 2004;379:841-8 pubmed
    ..The CaM-binding motif of AtCaMRLK was found to be conserved in several other members of the plant RLK family, suggesting a role for Ca2+/CaM in the regulation of RLK-mediated pathways. ..
  7. Dagher R, Briere C, Fève M, Zeniou M, Pigault C, Mazars C, et al. Calcium fingerprints induced by calmodulin interactors in eukaryotic cells. Biochim Biophys Acta. 2009;1793:1068-77 pubmed publisher
    ..In addition, the distinct Ca2+-fingerprints in tobacco and human tumor initiating glioblastoma cells induced by a given CaM interactor highlight the specificity of the Ca2+-signalosome in eukaryotic cells. ..
  8. Magnan F, Ranty B, Charpenteau M, Sotta B, Galaud J, Aldon D. Mutations in AtCML9, a calmodulin-like protein from Arabidopsis thaliana, alter plant responses to abiotic stress and abscisic acid. Plant J. 2008;56:575-89 pubmed publisher
    ..Mutations of the AtCML9 gene also alter the expression of several stress-regulated genes, suggesting that AtCML9 is involved in salt stress tolerance through its effects on the ABA-mediated pathways. ..
  9. Suhita D, Raghavendra A, Kwak J, Vavasseur A. Cytoplasmic alkalization precedes reactive oxygen species production during methyl jasmonate- and abscisic acid-induced stomatal closure. Plant Physiol. 2004;134:1536-45 pubmed
    ..Our results further indicate that JAR1, as OST1, functions upstream of ROS produced by NAD(P)H oxidases and that the cytoplasmic alkalization precedes ROS production during MJ or ABA signal transduction in guard cells. ..

More Information


  1. Quetglas S, Iborra C, Sasakawa N, De Haro L, Kumakura K, Sato K, et al. Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis. EMBO J. 2002;21:3970-9 pubmed
    ..The calmodulin- and phospholipid-binding domain of VAMP 2 is thus required for Ca(2+)-dependent exocytosis, possibly to regulate SNARE complex assembly. ..
  2. Kutuzov M, Solov eva O, Andreeva A, Bennett N. Protein Ser/Thr phosphatases PPEF interact with calmodulin. Biochem Biophys Res Commun. 2002;293:1047-52 pubmed
  3. Pardoux R, Sauge Merle S, Lemaire D, Delangle P, Guilloreau L, Adriano J, et al. Modulating uranium binding affinity in engineered calmodulin EF-hand peptides: effect of phosphorylation. PLoS ONE. 2012;7:e41922 pubmed publisher
    ..Together, our data demonstrate that the phosphoryl group plays a determining role in uranyl binding affinity to proteins at physiological pH...
  4. Monteiro P, Gilot D, Le Ferrec E, Rauch C, Lagadic Gossmann D, Fardel O. Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway. Mol Pharmacol. 2008;73:769-77 pubmed
    ..Taken together, these data identified the Ca(2+)/CaM/CaMKIalpha pathway as an important contributing factor to AhR-mediated genomic response. ..
  5. Bigot L, Shaik H, Bozzolan F, Party V, Lucas P, Debernard S, et al. Peripheral regulation by ecdysteroids of olfactory responsiveness in male Egyptian cotton leaf worms, Spodoptera littoralis. Insect Biochem Mol Biol. 2012;42:22-31 pubmed publisher
    ..Taken together, these molecular, electrophysiological, and behavioral results suggest a hormonal regulation of the peripheral olfactory processing in S. littoralis. ..
  6. Gaudioso C, Carlier E, Youssouf F, Clare J, Debanne D, Alcaraz G. Calmodulin and calcium differentially regulate the neuronal Nav1.1 voltage-dependent sodium channel. Biochem Biophys Res Commun. 2011;411:329-34 pubmed publisher
    ..Fluorescence spectroscopy measurements suggested that Ca(++) could bind the Nav1.1 C-terminal region with micromolar affinity. ..
  7. Perochon A, Dieterle S, Pouzet C, Aldon D, Galaud J, Ranty B. Interaction of a plant pseudo-response regulator with a calmodulin-like protein. Biochem Biophys Res Commun. 2010;398:747-51 pubmed publisher
    ..These findings suggest that binding of PRR2 to CML9 may be an important mechanism to modulate the physiological role of this transcription factor in plants. ..
  8. Leba L, Perochon A, Cheval C, Ranty B, Galaud J, Aldon D. CML9, a multifunctional Arabidopsis thaliana calmodulin-like protein involved in stress responses and plant growth?. Plant Signal Behav. 2012;7:1121-4 pubmed publisher
  9. Cheval C, Aldon D, Galaud J, Ranty B. Calcium/calmodulin-mediated regulation of plant immunity. Biochim Biophys Acta. 2013;1833:1766-71 pubmed publisher
    ..This article is part of a Special Issue entitled: 12th European Symposium on Calcium. ..
  10. Veneziano R, Rossi C, Chenal A, Devoisselle J, Ladant D, Chopineau J. Bordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayer. Proc Natl Acad Sci U S A. 2013;110:20473-8 pubmed publisher
    ..This study's in vitro demonstration of toxin translocation across a tBLM provides an opportunity to explore the molecular mechanisms of protein translocation across biological membranes in precisely defined experimental conditions...
  11. Labasque M, Reiter E, Becamel C, Bockaert J, Marin P. Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling. Mol Biol Cell. 2008;19:4640-50 pubmed publisher
    ..This signaling pathway might be involved in neurogenesis induced by chronic treatment with 5-HT(2C) receptor agonists and their antidepressant-like activity. ..
  12. Breton C, Chaboud A, Matthys Rochon E, Bates E, Cock J, Fromm H, et al. PCR-generated cDNA library of transition-stage maize embryos: cloning and expression of calmodulin genes during early embryogenesis. Plant Mol Biol. 1995;27:105-13 pubmed
    ..This library is the first described for early plant embryos and represents a breakthrough to isolate genes involved in embryo differentiation. ..
  13. Pourrut B, Perchet G, Silvestre J, Cecchi M, Guiresse M, Pinelli E. Potential role of NADPH-oxidase in early steps of lead-induced oxidative burst in Vicia faba roots. J Plant Physiol. 2008;165:571-9 pubmed
    ..Using the calcium entry blocker La(3+) or different concentrations of calcium in the extra-cellular medium, our data highlighted the implication of Ca(2+) channel in lead-induced oxidative burst...
  14. Baratier J, Peris L, Brocard J, Gory Fauré S, Dufour F, Bosc C, et al. Phosphorylation of microtubule-associated protein STOP by calmodulin kinase II. J Biol Chem. 2006;281:19561-9 pubmed
    ..Thus, STOP phosphorylation by CaMKII may promote STOP translocation from microtubules to synaptic compartments where it may interact with actin, which could be important for STOP function in synaptic plasticity. ..
  15. Stamboulian S, Moutin M, Treves S, Pochon N, Grunwald D, Zorzato F, et al. Junctate, an inositol 1,4,5-triphosphate receptor associated protein, is present in rodent sperm and binds TRPC2 and TRPC5 but not TRPC1 channels. Dev Biol. 2005;286:326-37 pubmed
    ..Altogether, these results provide a new hypothesis concerning sperm TRPC2 gating: TRPC2 activation may be due to modifications of its interaction with both junctate and IP3R, induced by depletion of calcium from the acrosomal vesicle. ..
  16. Ménétrey J, Bahloul A, Wells A, Yengo C, Morris C, Sweeney H, et al. The structure of the myosin VI motor reveals the mechanism of directionality reversal. Nature. 2005;435:779-85 pubmed
    ..This repositioning largely accounts for the reverse directionality of this class of myosin motors. We propose a model incorporating a kinesin-like uncoupling/docking mechanism to provide a full explanation of the movements of myosin VI. ..
  17. Levy J, Brès C, Geurts R, Chalhoub B, Kulikova O, Duc G, et al. A putative Ca2+ and calmodulin-dependent protein kinase required for bacterial and fungal symbioses. Science. 2004;303:1361-4 pubmed
    ..This indicates that calcium spiking is likely an essential component of the signaling cascade leading to nodule development and mycorrhizal infection, and sheds light on the biological role of plant CCaMKs. ..
  18. Gaillard S, Bartoli M, Castets F, Monneron A. Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1. FEBS Lett. 2001;508:49-52 pubmed
    ..2001) Mol. Biol. Cell 12, 663-673]. ..
  19. Malvoisin E, Wild F. Inhibition of HIV-1, HIV-2 and SIV envelope glycoprotein-mediated cell fusion by calmodulin. Virus Res. 1997;50:119-27 pubmed
    ..These observations may be important in understanding the mechanism of retroviral envelope glycoprotein-mediated cell fusion. Several possible mechanisms of action are discussed...
  20. Baouz S, Jacquet E, Bernardi A, Parmeggiani A. The N-terminal moiety of CDC25(Mm), a GDP/GTP exchange factor of Ras proteins, controls the activity of the catalytic domain. Modulation by calmodulin and calpain. J Biol Chem. 1997;272:6671-6 pubmed
    ..Together, these results emphasize the role of the other domains of CDC25(Mm) in controlling the activity of the catalytic domain and support the involvement of calmodulin and calpain in the in vivo regulation of the CDC25(Mm) activity. ..
  21. Vanoosthuyse V, Tichtinsky G, Dumas C, Gaude T, Cock J. Interaction of calmodulin, a sorting nexin and kinase-associated protein phosphatase with the Brassica oleracea S locus receptor kinase. Plant Physiol. 2003;133:919-29 pubmed publisher
    ..The sorting nexin also interacted with diverse members of the PRK family, suggesting that all three of the interacting proteins described here may play a general role in signal transduction by this family of proteins...
  22. Leba L, Cheval C, Ortiz Martín I, Ranty B, Beuzón C, Galaud J, et al. CML9, an Arabidopsis calmodulin-like protein, contributes to plant innate immunity through a flagellin-dependent signalling pathway. Plant J. 2012;71:976-89 pubmed publisher
    ..Collectively, using PAMP treatment and P. syringae strains, we have established that CML9 participates in plant innate immunity. ..
  23. Grimaud R, Ezraty B, Mitchell J, Lafitte D, Briand C, Derrick P, et al. Repair of oxidized proteins. Identification of a new methionine sulfoxide reductase. J Biol Chem. 2001;276:48915-20 pubmed publisher
    ..A possibility is that these two ubiquitous methionine sulfoxide reductases exhibit different substrate specificity...