Genomes and Genes
Experts and Doctors on calcium signaling in Germany
Topic: calcium signaling
Publications181 found, 100 shown here
- Mehlmer N, Parvin N, Hurst C, Knight M, Teige M, Vothknecht U. A toolset of aequorin expression vectors for in planta studies of subcellular calcium concentrations in Arabidopsis thaliana. J Exp Bot. 2012;63:1751-61 pubmed publisher..Stable Arabidopsis lines were generated and initial tests of several lines confirmed their feasibility to measure calcium signals in vivo. ..
- Chen X, Leischner U, Varga Z, Jia H, Deca D, Rochefort N, et al. LOTOS-based two-photon calcium imaging of dendritic spines in vivo. Nat Protoc. 2012;7:1818-29 pubmed publisher..Key aspects of the protocol, which can be completed in 5-6 h, include the use of a variant of high-speed two-photon imaging, refined surgery procedures and optimized tissue stabilization. ..
- Bosche B, Schafer M, Graf R, Härtel F, Schafer U, Noll T. Lithium prevents early cytosolic calcium increase and secondary injurious calcium overload in glycolytically inhibited endothelial cells. Biochem Biophys Res Commun. 2013;434:268-72 pubmed publisher..Though further research is needed, these findings provide a novel option for therapeutic strategies to protect the endothelium against imminent barrier failure...
- Schöniger S, Kopp M, Schomerus C, Maronde E, Dehghani F, Meiniel A, et al. Effects of neuroactive substances on the activity of subcommissural organ cells in dispersed cell and explant cultures. Cell Tissue Res. 2002;307:101-14 pubmed..Our data suggest that SP and ATP are involved in regulation of the activity of SCO cells. ..
- Idzko M, Dichmann S, Ferrari D, Di Virgilio F, la Sala A, Girolomoni G, et al. Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. Blood. 2002;100:925-32 pubmed
- Udvardi M, Scheible W. Plant science. GRAS genes and the symbiotic green revolution. Science. 2005;308:1749-50 pubmed
- Charpentier M, Bredemeier R, Wanner G, Takeda N, Schleiff E, Parniske M. Lotus japonicus CASTOR and POLLUX are ion channels essential for perinuclear calcium spiking in legume root endosymbiosis. Plant Cell. 2008;20:3467-79 pubmed publisher..They could either trigger the opening of calcium release channels or compensate the charge release during the calcium efflux as counter ion channels. ..
- Pilipiuk J, Lefebvre C, Wiesenfahrt T, Legouis R, Bossinger O. Increased IP3/Ca2+ signaling compensates depletion of LET-413/DLG-1 in C. elegans epithelial junction assembly. Dev Biol. 2009;327:34-47 pubmed publisher..Analysis of embryogenesis revealed that IP(3)/Ca(2+) signaling is also required during junction assembly in embryonic epithelia. ..
- Rehberg M, Lepier A, Solchenberger B, Osten P, Blum R. A new non-disruptive strategy to target calcium indicator dyes to the endoplasmic reticulum. Cell Calcium. 2008;44:386-99 pubmed..In addition, the method allowed rapid confocal imaging of Ca2+ release from the ER, after activation of metabotropic glutamate receptors, in the presence of extracellular Ca2+. ..
- Gupta M, Illich D, Gaarz A, Matzkies M, Nguemo F, Pfannkuche K, et al. Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar. BMC Dev Biol. 2010;10:98 pubmed publisher..These minor differences in the expression profiles may occur due to differential cellular composition of iPS-BCs and ES-BCs, due to retention of some genetic profile of somatic cells in differentiated iPS cell-derivatives, or both. ..
- Joesch M, Schnell B, Raghu S, Reiff D, Borst A. ON and OFF pathways in Drosophila motion vision. Nature. 2010;468:300-4 pubmed publisher..Thus, similar to the segregation of photoreceptor signals in ON and OFF bipolar cell pathways in the vertebrate retina, photoreceptor signals segregate into ON-L1 and OFF-L2 channels in the lamina of Drosophila. ..
- Witte I, Horke S. Assessment of endoplasmic reticulum stress and the unfolded protein response in endothelial cells. Methods Enzymol. 2011;489:127-46 pubmed publisher..Here, we describe how ER stress can be induced and assessed in cultured ECs and demonstrate their specific responses to classical ER stress conditions. ..
- Russo A, Schmid E, Nurbaeva M, Yang W, Yan J, Bhandaru M, et al. PKB/SGK-dependent GSK3-phosphorylation in the regulation of LPS-induced Ca2+ increase in mouse dendritic cells. Biochem Biophys Res Commun. 2013;437:336-41 pubmed publisher..In conclusion, PKB/SGK-dependent GSK3?,? activity participates in the regulation of Ca(2+) signaling in dendritic cells. ..
- Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, et al. BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival. Cell Death Differ. 2016;23:358-68 pubmed publisher..These results suggest that BI-1 has a major role in the functioning of the adaptive immune system by regulating intracellular Ca(2+) homeostasis in lymphocytes. ..
- Pahl A, Zhang M, Kuss H, Szelenyi I, Brune K. Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy. Br J Pharmacol. 2002;135:1915-26 pubmed..Characterizing highly potent inhibitors of IL-13 synthesis can be exploited to identify new drugs to treat immunological diseases such as asthma. ..
- zu Heringdorf D, Vincent M, Lipinski M, Danneberg K, Stropp U, Wang D, et al. Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1). Cell Signal. 2003;15:677-87 pubmed..Co-expression of S1P(1) with S1P(3), but not S1P(2), reversed the inhibitory effect of S1P(1), furthermore suggesting a specific interplay of S1P receptor subtypes usually found within a single cell type. ..
- Weiss F, Halangk W, Lerch M. New advances in pancreatic cell physiology and pathophysiology. Best Pract Res Clin Gastroenterol. 2008;22:3-15 pubmed publisher..This review will summarise recent advances in our understanding of the physiological mechanisms involved in the early disease processes of the exocrine pancreas. ..
- Eckert G, Wood W, Muller W. Lipid membranes and beta-amyloid: a harmful connection. Curr Protein Pept Sci. 2010;11:319-25 pubmed..Perturbation of membranes, binding to lipids and alteration of cellular calcium signaling by Abeta have been reported by several studies and these topics are examined in this review. ..
- Schlumm F, Mauceri D, Freitag H, Bading H. Nuclear calcium signaling regulates nuclear export of a subset of class IIa histone deacetylases following synaptic activity. J Biol Chem. 2013;288:8074-84 pubmed publisher..These results identify nuclear calcium as a regulator of nuclear export of HDAC4 and HDAC5. The reduction of nuclear localized HDACs represents a novel transcription-promoting pathway stimulated by nuclear calcium. ..
- Meyer zu Heringdorf D, Lass H, Kuchar I, Lipinski M, Alemany R, Rümenapp U, et al. Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. Eur J Pharmacol. 2001;414:145-54 pubmed
- Fueller M, Wang D, Tigyi G, Siess W. Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate. Cell Signal. 2003;15:367-75 pubmed..Our study is the first report showing the receptor-mediated activation of human monocytic cells by low nanomolar concentrations of LPA and S1P, and suggests a role of these lipid mediators in inflammation and atherogenesis. ..
- Spilker C, Braunewell K. Calcium-myristoyl switch, subcellular localization, and calcium-dependent translocation of the neuronal calcium sensor protein VILIP-3, and comparison with VILIP-1 in hippocampal neurons. Mol Cell Neurosci. 2003;24:766-78 pubmed..Thus, VILIPs co-expressed in the same neuron show clear differences in calcium-dependent localization which may allow neurons a highly selective response to various calcium stimuli. ..
- Egorov A, Angelova P, Heinemann U, Muller W. Ca2+-independent muscarinic excitation of rat medial entorhinal cortex layer V neurons. Eur J Neurosci. 2003;18:3343-51 pubmed..Thus, muscarinic depolarization of EC layer V neurons appears to be primarily mediated by Ca2+-independent activation of non-specific cation channels that conduct K+ about three times as well as Na+. ..
- Ziemek R, Brennauer A, Schneider E, Cabrele C, Beck Sickinger A, Bernhardt G, et al. Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y2 receptor ligands. Eur J Pharmacol. 2006;551:10-8 pubmed..Functional data of Y(2) receptor agonists and antagonists determined in the fluorescence- and luminescence-based assays were in good agreement. ..
- Dewor M, Steffens G, Krohn R, Weber C, Baron J, Bernhagen J. Macrophage migration inhibitory factor (MIF) promotes fibroblast migration in scratch-wounded monolayers in vitro. FEBS Lett. 2007;581:4734-42 pubmed
- Schwer C, Stoll P, Rospert S, Fitzke E, Schallner N, Bürkle H, et al. Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2. Int J Biochem Cell Biol. 2013;45:201-12 pubmed publisher..However, prolonged exogenous application of CO might also have negative effects on cellular protein homeostasis...
- Baden T, Schubert T, Chang L, Wei T, Zaichuk M, Wissinger B, et al. A tale of two retinal domains: near-optimal sampling of achromatic contrasts in natural scenes through asymmetric photoreceptor distribution. Neuron. 2013;80:1206-17 pubmed publisher..Therefore, the different cone types do not only form the basis of "color vision," but in addition represent distinct (achromatic) contrast-selective channels. ..
- Dhara M, Yarzagaray A, Schwarz Y, Dutta S, Grabner C, Moghadam P, et al. Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics. J Cell Biol. 2014;204:1123-40 pubmed publisher..Thus, our results illustrate how key features of CpxII, SytI, and their interplay transform the constitutively active SNARE-mediated fusion mechanism into a highly synchronized, Ca(2+)-triggered release apparatus. ..
- Tedford K, Nitschke L, Girkontaite I, Charlesworth A, Chan G, Sakk V, et al. Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nat Immunol. 2001;2:548-55 pubmed..These findings establish a role for Vav-2 in BCR calcium signaling and reveal that the Vav family of GEFs is critical to B cell development and function. ..
- Eilers J, Plant T, Marandi N, Konnerth A. GABA-mediated Ca2+ signalling in developing rat cerebellar Purkinje neurones. J Physiol. 2001;536:429-37 pubmed..Since such changes were shown to be Ca2+ dependent, we propose that GABA-evoked Ca2+ signalling is one of the critical determinants for the normal development of cerebellar PNs. ..
- Schwarzmann N, Kunerth S, Weber K, Mayr G, Guse A. Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex. J Biol Chem. 2002;277:50636-42 pubmed..These data suggest that the type 3 ryanodine receptor is essential in the sustained Ca(2+) response in T cells. ..
- Walther D, Peter J, Winter S, Höltje M, Paulmann N, Grohmann M, et al. Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. Cell. 2003;115:851-62 pubmed..Our data provides evidence for a receptor-independent signaling mechanism, termed herein as "serotonylation," which leads to alpha-granule exocytosis from platelets. ..
- Nitsch R, Pohl E, Smorodchenko A, Infante Duarte C, Aktas O, Zipp F. Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue. J Neurosci. 2004;24:2458-64 pubmed..This could be prevented by blocking both perforin and glutamate receptors. For the first time, our data provide direct insight into the activity of T cells in the living brain and their detrimental impact on neurons. ..
- Quintana A, Hoth M. Apparent cytosolic calcium gradients in T-lymphocytes due to fura-2 accumulation in mitochondria. Cell Calcium. 2004;36:99-109 pubmed..These methods are therefore suitable to study localized Ca2+ signals in large populations of T-cells while preserving their cytosolic integrity. ..
- Kahlert S, Schonfeld P, Reiser G. The Refsum disease marker phytanic acid, a branched chain fatty acid, affects Ca2+ homeostasis and mitochondria, and reduces cell viability in rat hippocampal astrocytes. Neurobiol Dis. 2005;18:110-8 pubmed..We suggest that the cytotoxic effect of phytanic acid seems to be due to a combined action on Ca2+ regulation, mitochondrial depolarization, and increased ROS generation in brain cells...
- Walzel H, Fahmi A, Eldesouky M, Abou Eladab E, Waitz G, Brock J, et al. Effects of N-glycan processing inhibitors on signaling events and induction of apoptosis in galectin-1-stimulated Jurkat T lymphocytes. Glycobiology. 2006;16:1262-71 pubmed..The data provide evidence that gal-1 triggers through binding to N-linked glycans a Ca(2+)-sensitive apoptotic pathway. ..
- Neulen A, Blaudeck N, Zittrich S, Metzler D, Pfitzer G, Stehle R. Mn2+-dependent protein phosphatase 1 enhances protein kinase A-induced Ca2+ desensitisation in skinned murine myocardium. Cardiovasc Res. 2007;74:124-32 pubmed..This can be ascribed to dephosphorylation of PKA-dependent phosphorylation sites. Hence PKA-dependent phosphorylation of sarcomeric proteins persists to a functionally relevant degree after the skinning procedure. ..
- Cordiglieri C, Odoardi F, Zhang B, Nebel M, Kawakami N, Klinkert W, et al. Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain. 2010;133:1930-43 pubmed publisher..Interference with this signalling pathway suppresses the formation of autoimmune inflammatory lesions and thus might qualify as a novel strategy for the treatment of T cell mediated autoimmune diseases. ..
- Schipke C, Heuser I, Peters O. Antidepressants act on glial cells: SSRIs and serotonin elicit astrocyte calcium signaling in the mouse prefrontal cortex. J Psychiatr Res. 2011;45:242-8 pubmed publisher..Astrocytic calcium signaling is elicited by SSRIs and 5-HT. They may serve as integrators, linking the serotonergic and glutamatergic signaling pathways...
- Malo A, Kruger B, Seyhun E, Schafer C, Hoffmann R, Goke B, et al. Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. Am J Physiol Gastrointest Liver Physiol. 2010;299:G877-86 pubmed publisher..These data hint new perspectives for an employment of chemical chaperones in the therapy of acute pancreatitis. ..
- Wiegert J, Oertner T. Long-term depression triggers the selective elimination of weakly integrated synapses. Proc Natl Acad Sci U S A. 2013;110:E4510-9 pubmed publisher..Our data suggest that LTD initially leads to homogeneous depression of synaptic function, followed by selective removal of unreliable synapses and recovery of function in the persistent fraction. ..
- Bickmeyer U, Grube A, Klings K, Köck M. Disturbance of voltage-induced cellular calcium entry by marine dimeric and tetrameric pyrrole--imidazole alkaloids. Toxicon. 2007;50:490-7 pubmed
- Pick R, Begandt D, Stocker T, Salvermoser M, Thome S, Böttcher R, et al. Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity. Blood. 2017;130:847-858 pubmed publisher..Thus, Coro1A represents an important novel player in integrin biology, with key functions in PMN trafficking during innate immunity. ..
- Ortner N, Bock G, Dougalis A, Kharitonova M, Duda J, Hess S, et al. Lower Affinity of Isradipine for L-Type Ca2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease. J Neurosci. 2017;37:6761-6777 pubmed publisher..2 LTCCs in resistance blood vessels (mediating dose-limiting vasodilating effects) and even at supratherapeutic concentrations isradipine fails to reduce somatic Ca2+ oscillations of SN DA neurons. ..
- Nofer J, Fobker M, Höbbel G, Voss R, Wolinska I, Tepel M, et al. Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux. Biochemistry. 2000;39:15199-207 pubmed..Apo A-I stimulates phosphatidylcholine breakdown and thereby facilitates cholesterol efflux, whereas LSF and SPC trigger PI-PLC activation and thereby stimulate cell proliferation. ..
- D Angelo C, Weinl S, Batistic O, Pandey G, Cheong Y, Schültke S, et al. Alternative complex formation of the Ca-regulated protein kinase CIPK1 controls abscisic acid-dependent and independent stress responses in Arabidopsis. Plant J. 2006;48:857-72 pubmed..Based on our genetic, physiological and protein-protein interaction data, we propose a general model for information processing in calcium-regulated signalling networks. ..
- Hoffmann A, Kann O, Ohlemeyer C, Hanisch U, Kettenmann H. Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): suppression of receptor-evoked calcium signaling and control of release function. J Neurosci. 2003;23:4410-9 pubmed..Elevation of basal [Ca 2+]i could thus prove a central element in the regulation of executive functions in activated microglia. ..
- Maggio N, Vlachos A. Synaptic plasticity at the interface of health and disease: New insights on the role of endoplasmic reticulum intracellular calcium stores. Neuroscience. 2014;281:135-46 pubmed publisher..We discuss the possibility that intracellular Ca(2+) stores may regulate synaptic plasticity and hence behavioral and cognitive functions at the interface between physiology and pathology. ..
- Oliveira A, Bading H. Calcium signaling in cognition and aging-dependent cognitive decline. Biofactors. 2011;37:168-74 pubmed publisher..We further describe evidence for dysregulation of the activity of these factors during aging. ..
- Roelfsema M, Hedrich R. Making sense out of Ca(2+) signals: their role in regulating stomatal movements. Plant Cell Environ. 2010;33:305-21 pubmed publisher..Future research may shed new light on the relation between parallel acting Ca(2+)-dependent and -independent events, and may provide insights in their evolutionary origin. ..
- Bahl A, Stemmler M, Herz A, Roth A. Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data. J Neurosci Methods. 2012;210:22-34 pubmed
- Osterhoff M, Mohlig M, Schwanstecher M, Seufert J, Ortmann J, Schatz H, et al. Ca2+/calmodulin-dependent protein kinase II delta2 regulates gene expression of insulin in INS-1 rat insulinoma cells. Cell Calcium. 2003;33:175-84 pubmed
- Lohn M, Jessner W, Furstenau M, Wellner M, Sorrentino V, Haller H, et al. Regulation of calcium sparks and spontaneous transient outward currents by RyR3 in arterial vascular smooth muscle cells. Circ Res. 2001;89:1051-7 pubmed..Our results suggest that RyR3 is part of the SR Ca(2+) spark release unit and plays a specific molecular role in the regulation of STOCs frequency in mouse cerebral artery VSMCs after decreased arterial tone. ..
- Kocksk mper J, Seidlmayer L, Walther S, Hellenkamp K, Maier L, Pieske B. Endothelin-1 enhances nuclear Ca2+ transients in atrial myocytes through Ins(1,4,5)P3-dependent Ca2+ release from perinuclear Ca2+ stores. J Cell Sci. 2008;121:186-95 pubmed publisher..This effect is mediated by the coupling of endothelin receptor A to PLC-Ins(1,4,5)P3 signalling and might contribute to excitation-transcription coupling...
- Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, et al. The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons. J Biol Chem. 2017;292:6123-6134 pubmed publisher..Thus, the data show that the two leukotriene B4 receptors have opposing roles in the sensitization of peripheral sensory neurons forming a self-restricting system. ..
- Keffel S, Alexandrov A, Goepel M, Michel M. alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells. Biochem Biophys Res Commun. 2000;272:906-11 pubmed..We conclude that within a given cell type alpha(1)-adrenoceptor subtypes can have opposite effects on cellular growth, although their proximal signal transduction displays only quantitative differences. ..
- Bihler H, Eing C, Hebeisen S, Roller A, Czempinski K, Bertl A. TPK1 is a vacuolar ion channel different from the slow-vacuolar cation channel. Plant Physiol. 2005;139:417-24 pubmed..Our data clearly demonstrate that TPK1 is a voltage-independent, Ca(2+)-activated, K(+)-selective ion channel in the vacuolar membrane that does not mediate SV-type ionic currents. ..
- Schillinger W, Teucher N, Sossalla S, Kettlewell S, Werner C, Raddatz D, et al. Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits: evaluation of mechanisms. Circulation. 2007;116:57-66 pubmed..Pantoprazole depresses cardiac contractility in vitro by depression of Ca2+ signaling and myofilament activity. In view of the extensive use of this agent, the effects should be evaluated in vivo. ..
- Spehr M, Gisselmann G, Poplawski A, Riffell J, Wetzel C, Zimmer R, et al. Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science. 2003;299:2054-8 pubmed..In contrast, undecanal was a potent OR antagonist to bourgeonal and related compounds. Taken together, these results indicate that hOR17-4 functions in human sperm chemotaxis and may be a critical component of the fertilization process. ..
- Diederichs F. Mathematical simulation of membrane processes and metabolic fluxes of the pancreatic beta-cell. Bull Math Biol. 2006;68:1779-818 pubmed..The simulation shows that the so-called pyruvate paradox possibly results from a relatively low membrane conductance of beta-cells for pyruvate. ..
- Molderings G, Bonisch H, Bruss M, Wolf C, von Kügelgen I, Gothert M. S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands. Neurochem Int. 2007;51:476-85 pubmed
- Burgalossi A, Jung S, Meyer G, Jockusch W, Jahn O, Taschenberger H, et al. SNARE protein recycling by ?SNAP and ?SNAP supports synaptic vesicle priming. Neuron. 2010;68:473-87 pubmed publisher..Our analysis of ?- and ?SNAP deletion mutant neurons shows that the two NSF cofactors support synaptic vesicle priming by determining the availability of free SNARE components, particularly during phases of high synaptic activity. ..
- Filipova D, Walter A, Gaspar J, Brunn A, Linde N, Ardestani M, et al. Gene profiling of embryonic skeletal muscle lacking type I ryanodine receptor Ca(2+) release channel. Sci Rep. 2016;6:20050 pubmed publisher..Taken together, these findings suggest an important non-contractile role of RyR1 or RYR1-mediated Ca(2+) signaling during muscle organ development. ..
- Segond Von Banchet G, Pastor A, Biskup C, Schlegel C, Benndorf K, Schaible H. Localization of functional calcitonin gene-related peptide binding sites in a subpopulation of cultured dorsal root ganglion neurons. Neuroscience. 2002;110:131-45 pubmed..The binding sites may serve as autoreceptors because all of these neurons also synthesize CGRP. The activation of CGRP binding sites may sensitize primary afferent neurons and influence the release of mediators. ..
- Sauer H, Stanelle R, Hescheler J, Wartenberg M. The DC electrical-field-induced Ca(2+) response and growth stimulation of multicellular tumor spheroids are mediated by ATP release and purinergic receptor stimulation. J Cell Sci. 2002;115:3265-73 pubmed
- Schomerus C, Laedtke E, Korf H. Activation of arylalkylamine N-acetyltransferase by phorbol esters in bovine pinealocytes suggests a novel regulatory pathway in melatonin synthesis. J Neuroendocrinol. 2004;16:741-9 pubmed..The study is of particular interest because regulation of melatonin biosynthesis in bovines may resemble that in primates more closely than that in rodents. ..
- Wennemuth G, Aumüller G. Angiotensin II-mediated calcium signals and mitogenesis in human prostate stromal cell line hPCPs. Br J Pharmacol. 2005;144:3-10 pubmed..The subsequently performed proliferation assay revealed a mitogenic effect of Ang II on hPCPs in concentrations starting at 10 nM. This effect could be inhibited by losartan. ..
- Levchenko V, Konrad K, Dietrich P, Roelfsema M, Hedrich R. Cytosolic abscisic acid activates guard cell anion channels without preceding Ca2+ signals. Proc Natl Acad Sci U S A. 2005;102:4203-8 pubmed..6 microM ABA. Our studies point to an ABA pathway initiated by ABA binding to a cytosolic receptor that within seconds activates anion channels, and in turn, leads to depolarization of the plasma membrane. ..
- Völkl T, Ogilvie A, Neuhuber W, Ogilvie A. Cell death induced by uridine 5'-triphosphate (UTP) in contrast to adenosine 5'-triphosphate (ATP) in human epidermoid carcinoma cells (A-431). Cell Physiol Biochem. 2008;22:441-54 pubmed publisher..In contrast, we were not able to demonstrate analogous mechanisms for cell death mediated by extracellular UTP, but were able to provide some evidence of classical ligand-receptor action of uncleaved UTP on A-431 cells. ..
- Richter R, Casarosa P, Ständker L, Munch J, Springael J, Nijmeijer S, et al. Significance of N-terminal proteolysis of CCL14a to activity on the chemokine receptors CCR1 and CCR5 and the human cytomegalovirus-encoded chemokine receptor US28. J Immunol. 2009;183:1229-37 pubmed publisher..Our results suggest that the activity of CCL14a might be regulated by stringent proteolytic activation and inactivation steps. ..
- Kusch U, Greiner S, Steininger H, Meyer A, Corbière Divialle H, Harms K, et al. Dissecting the regulation of fructan metabolism in chicory (Cichorium intybus) hairy roots. New Phytol. 2009;184:127-40 pubmed publisher..In summary, this study has established chicory HRCs as a convenient experimental system with which to study the regulation of fructan active enzyme (FAZY) expression in heterotrophic cells. ..
- Gao Y, Hanley P, Rinné S, Zuzarte M, Daut J. Calcium-activated K(+) channel (K(Ca)3.1) activity during Ca(2+) store depletion and store-operated Ca(2+) entry in human macrophages. Cell Calcium. 2010;48:19-27 pubmed publisher..1 channel current and hyperpolarization, providing the necessary electrochemical driving force for prolonged Ca(2+) signaling and store repletion. ..
- Pegoraro S, Lang M, Dreker T, Kraus J, Hamm S, Meere C, et al. Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett. 2009;19:2299-304 pubmed publisher..These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model. ..
- Barmashenko G, Eysel U, Mittmann T. Intracellular calcium signals in the surround of rat visual cortex lesions. Neuroreport. 2001;12:3023-8 pubmed..This increase in [Ca2+]i might be an important factor for lesion-induced functional reorganization in the rat visual cortex. ..
- Pervushina O, Scheuerer B, Reiling N, Behnke L, Schröder J, Kasper B, et al. Platelet factor 4/CXCL4 induces phagocytosis and the generation of reactive oxygen metabolites in mononuclear phagocytes independently of Gi protein activation or intracellular calcium transients. J Immunol. 2004;173:2060-7 pubmed..Taken together, PF-4 may play a crucial role in the induction and maintenance of an unspecific immune response. ..
- Rafalzik S, Pehl U, Ott D, Strotmann J, Wolff M, Gerstberger R. Cholinergic signal transduction in the mouse sphenopalatine ganglion. Brain Res. 2008;1241:42-55 pubmed publisher..Nicotinic signal transduction did not prove to be different in GFP-positive as compared to-negative murine SPG neurons. ..
- Kruska N, Reiser G. Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40. Neurobiol Dis. 2011;43:465-72 pubmed publisher..Therefore, we suppose that activation of GPR40 might be part of the signaling cascade of the toxicity of phytanic and pristanic acids...
- Kaufmann R, Junker U, Schilli Westermann M, Klötzer C, Scheele J, Junker K. Meizothrombin, an intermediate of prothrombin cleavage potently activates renal carcinoma cells by interaction with PAR-type thrombin receptors. Oncol Rep. 2003;10:493-6 pubmed..Our results demonstrate rMT as a potent activator of human RCC cells suggesting a function of not only thrombin but also of this catalytically active thrombin precursor enzyme in human renal cell carcinoma. ..
- Sandmann G, Siess W, Essler M. Lysophosphatidic acid is the unique platelet-activating substance in human malignant ascites. Eur J Med Res. 2003;8:397-404 pubmed..We propose that LPA receptor antagonists could be effective in blocking cancer-associated platelet activation and thus preventing thrombosis. ..
- Haas B, Schipke C, Peters O, Sohl G, Willecke K, Kettenmann H. Activity-dependent ATP-waves in the mouse neocortex are independent from astrocytic calcium waves. Cereb Cortex. 2006;16:237-46 pubmed..Our findings indicate that astrocytes propagate calcium signals by two separate mechanisms depending on the brain region and that ATP release can propagate within the neocortex independent from calcium waves. ..
- Pandey D, Goyal P, Siess W. Lysophosphatidic acid stimulation of platelets rapidly induces Ca2+-dependent dephosphorylation of cofilin that is independent of dense granule secretion and aggregation. Blood Cells Mol Dis. 2007;38:269-79 pubmed..However, a rapid dephosphorylation of cofilin occurs during secretion and aggregation, which is Ca(2+)-dependent, upstream of secretion and aggregation and might regulate these platelet responses. ..
- Pauly B, Lasi M, MacKintosh C, Morrice N, Imhof A, Regula J, et al. Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signalling. BMC Cell Biol. 2007;8:31 pubmed publisher..We also discuss the possibility that they are involved in the regulation of cell numbers in response to food supply in Hydra...
- Weiergräber M, Stephani U, Köhling R. Voltage-gated calcium channels in the etiopathogenesis and treatment of absence epilepsy. Brain Res Rev. 2010;62:245-71 pubmed publisher..Finally, various antiepileptic drugs that have been proven to or are supposed to exert anti-absence effects are discussed with respect to their pharmacodynamics and pharmacokinetics. ..
- Kuhn S, van Landeghem F, Zacharias R, Färber K, Rappert A, Pavlovic S, et al. Microglia express GABA(B) receptors to modulate interleukin release. Mol Cell Neurosci. 2004;25:312-22 pubmed..This release activity was attenuated by simultaneous activation of the GABA(B) receptors indicating that GABA can modulate the microglial immune response. ..
- Brackmann M, Zhao C, Kuhl D, Manahan Vaughan D, Braunewell K. MGluRs regulate the expression of neuronal calcium sensor proteins NCS-1 and VILIP-1 and the immediate early gene arg3.1/arc in the hippocampus in vivo. Biochem Biophys Res Commun. 2004;322:1073-9 pubmed..Therefore, mGluRs at concentrations which induce synaptic plasticity regulate the expression of IEGs and NCS proteins in different time frames and thus contribute to late phases of synaptic plasticity. ..
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