Genomes and Genes
Experts and Doctors on calcium in United States
Locale: United States
Publications478 found, 100 shown here
- Bers D. Cardiac ryanodine receptor phosphorylation: target sites and functional consequences. Biochem J. 2006;396:e1-3 pubmed..This study brings some new answers, but also raises additional new questions that will require further investigation. ..
- Wallace K. Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis. Cardiovasc Toxicol. 2007;7:101-7 pubmed
- Cisz M, Lee P, Rietsch A. ExoS controls the cell contact-mediated switch to effector secretion in Pseudomonas aeruginosa. J Bacteriol. 2008;190:2726-38 pubmed..The requirement for a host cell cofactor to control effector secretion may help explain the recently observed phenomenon of target cell specificity in both the Yersinia and P. aeruginosa type III secretion systems. ..
- Arrington D, Schnellmann R. Targeting of the molecular chaperone oxygen-regulated protein 150 (ORP150) to mitochondria and its induction by cellular stress. Am J Physiol Cell Physiol. 2008;294:C641-50 pubmed..Our data also reveal that ORP150 is a substrate for mitochondrial calpain 10. ..
- Monshausen G, Messerli M, Gilroy S. Imaging of the Yellow Cameleon 3.6 indicator reveals that elevations in cytosolic Ca2+ follow oscillating increases in growth in root hairs of Arabidopsis. Plant Physiol. 2008;147:1690-8 pubmed publisher..These observations are consistent with a model in which the maximal oscillatory increase in cytosolic Ca(2+) is triggered by cell expansion associated with tip growth and plays a role in the subsequent restriction of growth. ..
- Ohrtman J, Ritter B, Polster A, Beam K, Papadopoulos S. Sequence differences in the IQ motifs of CaV1.1 and CaV1.2 strongly impact calmodulin binding and calcium-dependent inactivation. J Biol Chem. 2008;283:29301-11 pubmed publisher..Thus, our results reveal that a conserved difference between the IQ motifs of Ca(V)1.2 and Ca(V)1.1 has a profound effect on both CaM binding and calcium-dependent inactivation. ..
- Gossl M, Versari D, Hildebrandt H, Bajanowski T, Sangiorgi G, Erbel R, et al. Segmental heterogeneity of vasa vasorum neovascularization in human coronary atherosclerosis. JACC Cardiovasc Imaging. 2010;3:32-40 pubmed publisher..Our results support a possible role of VV neovascularization, VV rupture, and intraplaque hemorrhage in the progression and complications of human coronary atherosclerosis. ..
- Nieves N, Ahrens J, Plum L, DeLuca H, Clagett Dame M. Identification of a unique subset of 2-methylene-19-nor analogs of vitamin D with comedolytic activity in the rhino mouse. J Invest Dermatol. 2010;130:2359-67 pubmed publisher..Further, the activity of vitamin D analogs in causing epidermal hyperproliferation has been distinguished from that resulting in a reduction in utricle size. ..
- Ho H, Stevens S, Terentyeva R, Carnes C, Terentyev D, Gyorke S. Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors. J Physiol. 2011;589:4697-708 pubmed publisher..These CG-dependent effects probably involve release of ROS from mitochondria possibly mediated by NADPH oxidase. ..
- Hou Z, Hu Z, Blackwell D, Miller T, Thomas D, Robia S. 2-Color calcium pump reveals closure of the cytoplasmic headpiece with calcium binding. PLoS ONE. 2012;7:e40369 pubmed publisher..In addition, the 2-color SERCA constructs developed for this study may be useful for evaluating candidate small molecule regulators of Ca uptake activity. ..
- Martinez N, Risco C, Lima F, Bisinotto R, Greco L, Ribeiro E, et al. Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease. J Dairy Sci. 2012;95:7158-72 pubmed publisher..Finally, the population risk to develop uterine diseases attributable to SCH was 66.6% for metritis and 91.3% for puerperal metritis in the present study. ..
- El Khattouti A, Selimovic D, Hannig M, Taylor E, Abd Elmageed Z, Hassan S, et al. Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-ÎºB inhibition. J Cell Mol Med. 2016;20:266-86 pubmed publisher..These findings support the use of either IKK inhibitors or IAP antagonists as adjuvant therapies to improve the effectiveness topical imiquimod in the treatment of melanoma. ..
- Berglund I, Jacobs B, Allen K, Kim S, Pozzi A, Allen J, et al. Peri-implant tissue response and biodegradation performance of a Mg-1.0Ca-0.5Sr alloy in rat tibia. Mater Sci Eng C Mater Biol Appl. 2016;62:79-85 pubmed publisher..Principle findings also include new bone formation in the area of the implant, suggesting that the alloy is a promising candidate for biodegradable orthopedic implants. ..
- Ardiel E, Kumar A, Marbach J, Christensen R, Gupta R, Duncan W, et al. Visualizing Calcium Flux in Freely Moving Nematode Embryos. Biophys J. 2017;112:1975-1983 pubmed publisher..Finally, imaging neurons of a well-defined adult motor circuit, we found that reversals in the eggshell correlated with calcium transients in AVA interneurons. ..
- Khairallah P, Isakova T, Asplin J, Hamm L, Dobre M, Rahman M, et al. Acid Load and Phosphorus Homeostasis in CKD. Am J Kidney Dis. 2017;70:541-550 pubmed publisher..Understanding whether administration of base can lower phosphorus concentrations requires testing in interventional trials. ..
- Rafuse V, Landmesser L. Contractile activity regulates isoform expression and polysialylation of NCAM in cultured myotubes: involvement of Ca2+ and protein kinase C. J Cell Biol. 1996;132:969-83 pubmed..Taken together, these results suggest that Ca2+ ions and protein kinase C are involved in a second messenger cascade coupling membrane depolarization with transcriptional factors that regulate NCAM isoform synthesis and polysialylation. ..
- Barria A, Muller D, Derkach V, Griffith L, Soderling T. Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. Science. 1997;276:2042-5 pubmed..This covalent modulation of AMPA-Rs in LTP provides a postsynaptic molecular mechanism for synaptic plasticity. ..
- MacDonald M, Al Masri H, Jumelle Laclau M, Cruz M. Oscillations in activities of enzymes in pancreatic islet subcellular fractions induced by physiological concentrations of effectors. Diabetes. 1997;46:1996-2001 pubmed..If this is the case, pacemaker activity may result from complex effects distributed across multiple regulatory sites in both the cytosol and mitochondria, rather than from a single enzyme acting as a primary pacemaker. ..
- Xia X, Hirschberg B, Smolik S, Forte M, Adelman J. dSLo interacting protein 1, a novel protein that interacts with large-conductance calcium-activated potassium channels. J Neurosci. 1998;18:2360-9 pubmed..Single-channel recordings and immunostaining of transfected tissue culture cells suggest that dSLIP1 selectively reduces Slo BK currents by reducing the number of BK channels in the plasma membrane. ..
- Perez Villar J, Whitney G, Bowen M, Hewgill D, Aruffo A, Kanner S. CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1. Mol Cell Biol. 1999;19:2903-12 pubmed..These results suggest a critical role of the CD5 ITIM-like motif, which by binding to SHP-1 mediates the down-regulatory activity of this receptor. ..
- Viner R, Ferrington D, Williams T, Bigelow D, SCHONEICH C. Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle. Biochem J. 1999;340 ( Pt 3):657-69 pubmed
- Premkumar L, Ahern G. Induction of vanilloid receptor channel activity by protein kinase C. Nature. 2000;408:985-90 pubmed..These results suggest that PKC may link a range of stimuli to the activation of VRs. ..
- Patel J, Fitzsimons D, Buck S, Muthuchamy M, Wieczorek D, Moss R. PKA accelerates rate of force development in murine skinned myocardium expressing alpha- or beta-tropomyosin. Am J Physiol Heart Circ Physiol. 2001;280:H2732-9 pubmed..These results show that PKA-mediated phosphorylation of myofibrillar proteins significantly alters the static and dynamic mechanical properties of myocardium, and these effects occur regardless of the type of Tm expressed...
- Melendez P, Donovan G, Risco C, Littell R, Goff J. Effect of calcium-energy supplements on calving-related disorders, fertility and milk yield during the transition period in cows fed anionic diets. Theriogenology. 2003;60:843-54 pubmed..RFM and displacement of the abomasum were associated with ketosis. Ketosis and age were related to displacement of the abomasum. Parity, BCS, ovarian cysts, RFM and metritis were associated with fertility...
- Biehn S, Czymmek K, Leavens K, Karin N. Expression of the sarco/endoplasmic Ca(2+)-ATPase, SERCA1a, in fibroblasts induces the formation of organelle membrane arrays. Exp Cell Res. 2004;292:78-88 pubmed
- Lee Y, Tanner J, Larson J, Henzl M. Crystal structure of a high-affinity variant of rat alpha-parvalbumin. Biochemistry. 2004;43:10008-17 pubmed..In 0.15 M KCl and 0.025 M Hepes-KOH (pH 7.4) at 5 degrees C, the macroscopic Ca2+ binding constants are 1.8 x 10(10) and 2.0 x 10(9) M(-1). The corresponding Mg2+ binding constants are 2.7 x 10(6) and 1.2 x 10(5) M(-1). ..
- Henzl M, Agah S, Larson J. Association of the AB and CD-EF domains from rat alpha- and beta-parvalbumin. Biochemistry. 2004;43:10906-17 pubmed..Thus, the interaction between the beta AB domain and beta CD-EF domain may act to attenuate Ca(2+) affinity in the intact protein. ..
- Jensen B, Farach Carson M, Kenaley E, Akanbi K. High extracellular calcium attenuates adipogenesis in 3T3-L1 preadipocytes. Exp Cell Res. 2004;301:280-92 pubmed..These results suggest that continuous exposure to high [Ca(2+)](e) inhibits preadipocyte differentiation and that this may involve a G-protein-coupled mechanism mediated by a novel Ca(2+) sensor or receptor. ..
- Schenck P, Chew D. Prediction of serum ionized calcium concentration by use of serum total calcium concentration in dogs. Am J Vet Res. 2005;66:1330-6 pubmed..Use of tCa or adjusted tCa concentrations to predict iCa status in dogs could cause serious mistakes in diagnosis and case management, especially in dogs with CRF. ..
- Sanchez A, Aranda Michel J. Liver disease and osteoporosis. Nutr Clin Pract. 2006;21:273-8 pubmed..Early evaluation, screening, and treatment of bone disorders in patients with liver disease are essential to minimize fracture risk and to improve clinical outcome and quality of life. ..
- Arrington D, Van Vleet T, Schnellmann R. Calpain 10: a mitochondrial calpain and its role in calcium-induced mitochondrial dysfunction. Am J Physiol Cell Physiol. 2006;291:C1159-71 pubmed..In conclusion, calpain 10 is the first reported mitochondrially targeted calpain and is a mediator of mitochondrial dysfunction through the cleavage of Complex I subunits and activation of MPT...
- Fayiga A, Ma L, Zhou Q. Effects of plant arsenic uptake and heavy metals on arsenic distribution in an arsenic-contaminated soil. Environ Pollut. 2007;147:737-42 pubmed..007) correlated with plant arsenic removal. The plant's ability to solubilize soil arsenic from recalcitrant fractions may have enhanced its ability to hyperaccumulate arsenic. ..
- Weenig R. Pathogenesis of calciphylaxis: Hans Selye to nuclear factor kappa-B. J Am Acad Dermatol. 2008;58:458-71 pubmed publisher..As the pathogenesis of calciphylaxis is better understood, targeted therapies aimed at disease prevention and reversal will follow. ..
- Chua C, Gao J, Ho Y, Xu X, Kuo I, Chua K, et al. Over-expression of a modified bifunctional apoptosis regulator protects against cardiac injury and doxorubicin-induced cardiotoxicity in transgenic mice. Cardiovasc Res. 2009;81:20-7 pubmed publisher..Our results demonstrate that over-expression of BAR Delta RING renders the heart more resistant to I/R injury and DOX-induced cardiotoxicity, and this protection correlates with reduced cardiomyocyte apoptosis. ..
- Whitworth K, Li R, Spate L, Wax D, Rieke A, Whyte J, et al. Method of oocyte activation affects cloning efficiency in pigs. Mol Reprod Dev. 2009;76:490-500 pubmed publisher..The beneficial effect of NT2 protocol may be due to the stimulation of proteasomes that infiltrate donor cell nucleus shortly after nuclear transfer. ..
- Chen X, Kintner D, Baba A, Matsuda T, Shull G, Sun D. Protein aggregation in neurons following OGD: a role for Na+ and Ca2+ ionic dysregulation. J Neurochem. 2010;112:173-82 pubmed publisher..We conclude that overstimulation of NKCC1 and NCX(rev) following OGD/REOX partially contributes to protein aggregation and proteasome dysfunction as a result of ionic dysregulation...
- Das A, McDowell M, Pava M, Smith J, Reiter R, Woodward J, et al. The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-alpha toxicity involves membrane melatonin receptors. J Pineal Res. 2010;48:157-69 pubmed publisher..1 motoneuron apoptosis. Results suggest that neuroprotection rendered by melatonin to motoneurons is receptor mediated and melatonin may be an effective neuroprotective agent to attenuate motoneuron death in CNS injuries and diseases. ..
- Kim E, Owen B, Holmes W, Grover L. Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1. J Neurophysiol. 2012;108:1965-76 pubmed publisher..Our results indicate that decreased presynaptic axon excitability contributes to depression of excitatory synaptic transmission during HFS at synapses between Schaffer collaterals and CA1 pyramidal neurons. ..
- Chen M, Bresnick A, O Connor K. Coupling S100A4 to Rhotekin alters Rho signaling output in breast cancer cells. Oncogene. 2013;32:3754-64 pubmed publisher..Accordingly, our data suggest that interaction of S100A4 and Rhotekin permits S100A4 to complex with RhoA and switch Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotype. ..
- Billings S, Ballantyne F. How interactions between microbial resource demands, soil organic matter stoichiometry, and substrate reactivity determine the direction and magnitude of soil respiratory responses to warming. Glob Chang Biol. 2013;19:90-102 pubmed publisher..We use this exercise to highlight ideas for future research that will develop our abilities to predict SOM feedbacks to climate. ..
- Gamby C, Waage M, Allen R, Baizer L. Analysis of the role of calmodulin binding and sequestration in neuromodulin (GAP-43) function. J Biol Chem. 1996;271:26698-705 pubmed..In contrast, the morphological changes depend only on membrane association. Thus, the multitude of effects of neuromodulin noted in previous studies may result from divergent properties of this protein. ..
- Nguyen T, Moody M, Steinhoff M, Okolo C, Koh D, Bunnett N. Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest. 1999;103:261-9 pubmed..In pancreatitis, when trypsinogen is prematurely activated, PAR-2-mediated ductal secretion may promote clearance of toxins and debris. ..
- Miller V, Clouse W, Tonnessen B, Boston U, Severson S, Bonde S, et al. Time and dose effect of transdermal nicotine on endothelial function. Am J Physiol Heart Circ Physiol. 2000;279:H1913-21 pubmed..This complex relationship of duration and dose of nicotine treatment may explain, in part, discrepancies in effects of nicotine on endothelium-dependent responses...
- Tang J, Lin Y, Zhang Z, Tikunova S, Birnbaumer L, Zhu M. Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. J Biol Chem. 2001;276:21303-10 pubmed..Our data support the view that both CaM and IP(3)Rs play important roles in controlling the gating of Trp-based channels. However, the sensitivity and responses to CaM and IP(3)Rs differ for each Trp. ..
- Mitra P, Slaughter M. Calcium-induced transitions between the spontaneous miniature outward and the transient outward currents in retinal amacrine cells. J Gen Physiol. 2002;119:373-88 pubmed..Based on their characteristics, SMOCs in retinal neurons may function as synaptic noise suppressors at quiescent glutamatergic synapses...
- Ge S, Pachter J. Caveolin-1 knockdown by small interfering RNA suppresses responses to the chemokine monocyte chemoattractant protein-1 by human astrocytes. J Biol Chem. 2004;279:6688-95 pubmed..The results highlight a potentially prominent role for caveolae and/or caveolin-1 in mediating astrocyte responses to MCP-1, a feature that might significantly dictate the progression of inflammatory events at the blood-brain barrier. ..
- Tikunova S, Davis J. Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C. J Biol Chem. 2004;279:35341-52 pubmed..The design of calcium-sensitizing cardiac troponin C mutants presented in this work enhances the understanding of how to control cation binding properties of EF-hand proteins and ultimately their structure and physiological function. ..
- Fellner S, Parker L. Endothelin-1, superoxide and adeninediphosphate ribose cyclase in shark vascular smooth muscle. J Exp Biol. 2005;208:1045-52 pubmed..We show for the first time that in shark VSM, inhibition of the ADPR cyclase reduces the [Ca(2+)](i) response to ET-1 and that superoxide may be involved in the activation of the cyclase...
- Song X, Daniels G, Feldmann D, Gurevich A, Larbalestier D. Electromagnetic, atomic structure and chemistry changes induced by Ca-doping of low-angle YBa2Cu3O7-delta grain boundaries. Nat Mater. 2005;4:470-5 pubmed
- Kim E, Tam M, Siems W, Kang C. Effects of drugs with muscle-related side effects and affinity for calsequestrin on the calcium regulatory function of sarcoplasmic reticulum microsomes. Mol Pharmacol. 2005;68:1708-15 pubmed..We therefore propose that a certain portion of the muscle-related (both cardiac and skeletal) complications of these drugs is caused by the altered Ca2+ regulation of the SR mediated by their adverse interaction with CSQ. ..
- Windelborn J, Lipton P. Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA-mediated calcium influx, arachidonic acid metabolism, and free radical production. J Neurochem. 2008;106:56-69 pubmed publisher..It is concluded that LMP results in part from calcium-initiated and extracellular signal-regulated kinase-initiated arachidonic acid metabolism, which produces free radicals; it also requires the action of calpain. ..
- Przybelski R, Agrawal S, Krueger D, Engelke J, Walbrun F, Binkley N. Rapid correction of low vitamin D status in nursing home residents. Osteoporos Int. 2008;19:1621-8 pubmed publisher..No hypercalcemia or other adverse effects were observed with ergocalciferol treatment. Four weeks of oral vitamin D(2) supplementation effectively and safely normalizes serum 25(OH)D in nursing home residents. ..
- El Abbadi M, Pai A, Leaf E, Yang H, Bartley B, Quan K, et al. Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. Kidney Int. 2009;75:1297-1307 pubmed publisher..These findings suggest that phosphate loading and the severity of uremia play critical roles in controlling arterial medial calcification in mice. Further, FGF-23 and osteopontin may be markers and/or inducers of this process. ..
- Navaneethan S, Palmer S, Craig J, Elder G, Strippoli G. Benefits and harms of phosphate binders in CKD: a systematic review of randomized controlled trials. Am J Kidney Dis. 2009;54:619-37 pubmed publisher..Phosphate binders are widely used to control serum phosphorus levels in patients with chronic kidney disease (CKD). We analyzed the effects of phosphate binders on biochemical and patient-level end points in patients with CKD...
- Lesich K, Zhang Z, Kelsch C, Ponichter K, Strauss J, Lindemann C. Functional deficiencies and a reduced response to calcium in the flagellum of mouse sperm lacking SPAG16L. Biol Reprod. 2010;82:736-44 pubmed publisher..This deficit in motor function, and an increased rigidity of the midpiece region which we detected in the passive flagella, together can explain the observed motility characteristics of the Spag16L-null sperm...
- Ghanam R, Fernandez T, Fledderman E, Saad J. Binding of calmodulin to the HIV-1 matrix protein triggers myristate exposure. J Biol Chem. 2010;285:41911-20 pubmed publisher..We believe that our findings will provide new insights on how Gag may interact with CaM during the HIV replication cycle. ..
- Baldys A, Raymond J. Role of c-Cbl carboxyl terminus in serotonin 5-HT2A receptor recycling and resensitization. J Biol Chem. 2011;286:24656-65 pubmed publisher..Taken together, these studies have led to the discovery that the C-terminal region of c-Cbl plays a crucial role in the temporal and spatial control of 5-HT(2A)R recycling. ..
- Sathish V, Delmotte P, Thompson M, Pabelick C, Sieck G, Prakash Y. Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle. PLoS ONE. 2011;6:e23662 pubmed publisher..These data suggest that NCX-mediated Ca(2+) fluxes normally exist in human ASM (potentially contributing to rapid Ca(2+) fluxes), and contribute to enhanced [Ca(2+)](i) regulation in airway inflammation. ..
- Clines G. Mechanisms and treatment of hypercalcemia of malignancy. Curr Opin Endocrinol Diabetes Obes. 2011;18:339-46 pubmed publisher..Bisphosphonates and other novel therapies being evaluated in clinical trial target this bone-resorbing cell type and provide effective and durable serum calcium reduction. ..
- Kang M, Chung K. PKC-? mediates multiple endothelin-1 actions on systolic Ca2+ and contractility in ventricular myocytes. Biochem Biophys Res Commun. 2012;423:600-5 pubmed publisher..This report provides direct evidence that PKC-? is activated early and robustly following ET-1 stimulation and thus mediates multiple intracellular changes underlying the acute actions of ET-1 on myocardium. ..
- Thomas A, Hailey D, Stawicki T, Wu P, Coffin A, Rubel E, et al. Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line. J Neurosci. 2013;33:4405-14 pubmed publisher..These findings demonstrate that cisplatin-induced hair cell death is dependent on functional mechanotransduction in the zebrafish lateral line...
- Kohler M, Hirschberg B, Bond C, Kinzie J, Marrion N, Maylie J, et al. Small-conductance, calcium-activated potassium channels from mammalian brain. Science. 1996;273:1709-14 pubmed
- Chakravarty L, Rogers L, Quach T, Breckenridge S, Kolattukudy P. Lysine 58 and histidine 66 at the C-terminal alpha-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding. J Biol Chem. 1998;273:29641-7 pubmed..Therefore, we conclude that the Lys-58 and His-66 residues in the C-terminal alpha-helix of MCP-1 are essential for glycosaminoglycan binding and probably for the binding to the endothelial surface proteoglycans. ..
- Said H, Ortiz A, Moyer M, Yanagawa N. Riboflavin uptake by human-derived colonic epithelial NCM460 cells. Am J Physiol Cell Physiol. 2000;278:C270-6 pubmed..It is suggested that the identified transport system may be involved in the absorption of bacterially synthesized RF in the large intestine and that this source of RF may contribute toward RF homeostasis, especially that of colonocytes...
- Lu Z, Swartz D, Metzger J, Moss R, Walker J. Regulation of force development studied by photolysis of caged ADP in rabbit skinned psoas fibers. Biophys J. 2001;81:334-44 pubmed..This cooperative interaction influences both the magnitude and kinetics of force generation in skeletal muscle. ..
- Burgess D, Crawford O, Delisle B, Satin J. Mechanism of inactivation gating of human T-type (low-voltage activated) calcium channels. Biophys J. 2002;82:1894-906 pubmed..We have integrated these concepts into an eight-state kinetic model, which can account for the major characteristics of T-type Ca channel inactivation. ..
- Verbny Y, Zhang C, Chiu S. Coupling of calcium homeostasis to axonal sodium in axons of mouse optic nerve. J Neurophysiol. 2002;88:802-16 pubmed
- Trudeau M, Zagotta W. Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels. J Biol Chem. 2003;278:18705-8 pubmed..Here, we will review recent advances in understanding the subunit composition and the mechanisms and roles for Ca2+/CaM-dependent inhibition in olfactory and rod CNG channels. ..
- Brown D, Bruce J, Straub S, Yule D. cAMP potentiates ATP-evoked calcium signaling in human parotid acinar cells. J Biol Chem. 2004;279:39485-94 pubmed..These data indicate that in human parotid acinar cells, in addition to modulation of Ca(2+) release, Ca(2+) influx through P2X(4)R may constitute a further locus for the synergistic effects of Ca(2+) and PKA activation. ..
- Traaseth N, Elfering S, Solien J, Haynes V, Giulivi C. Role of calcium signaling in the activation of mitochondrial nitric oxide synthase and citric acid cycle. Biochim Biophys Acta. 2004;1658:64-71 pubmed..This would ensue in changes in the NADH/NAD and ATP/ADP ratios, which would influence the rate of the cycle and the oxygen diffusion. ..
- Huan J, Streicher J, Bleyle L, Koop D. Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells. Toxicol Appl Pharmacol. 2004;199:332-43 pubmed..Furthermore, the addition of the hsp90 inhibitors geldanamycin, herbimycin, and radicicol had no effect on the turnover of CYP2E1, differentiating the degradation of CYP2E1 from other substrates for proteasome-dependent degradation. ..
- Wu Z, Tandon R, Ziembicki J, Nagano J, Hujer K, Miller R, et al. Role of ceramide in Ca2+-sensing receptor-induced apoptosis. J Lipid Res. 2005;46:1396-404 pubmed
- Stork C, Li Y. Intracellular zinc elevation measured with a "calcium-specific" indicator during ischemia and reperfusion in rat hippocampus: a question on calcium overload. J Neurosci. 2006;26:10430-7 pubmed
- Altschafl B, Beutner G, Sharma V, Sheu S, Valdivia H. The mitochondrial ryanodine receptor in rat heart: a pharmaco-kinetic profile. Biochim Biophys Acta. 2007;1768:1784-95 pubmed..These results therefore provide the first direct evidence that a unique RyR occurs in mitochondrial membranes. ..
- Babu G, Bhupathy P, Timofeyev V, Petrashevskaya N, Reiser P, Chiamvimonvat N, et al. Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility. Proc Natl Acad Sci U S A. 2007;104:17867-72 pubmed..Our study documented that sarcolipin is a key regulator of SERCA2a in atria. Importantly, our data demonstrate the existence of distinct modulators for the SERCA pump in the atria and ventricles. ..
- Henzl M, Davis M, Tan A. Leucine 85 is an important determinant of divalent ion affinity in rat beta-parvalbumin (Oncomodulin). Biochemistry. 2008;47:13635-46 pubmed publisher..Interestingly, however, significant improvement in CD site Mg(2+) affinity also requires mutation of additional CD site residues. ..
- Du L, Ali G, Simons K, Hou J, Yang T, Reddy A, et al. Ca(2+)/calmodulin regulates salicylic-acid-mediated plant immunity. Nature. 2009;457:1154-8 pubmed publisher..These results reveal a previously unknown regulatory mechanism linking Ca(2+) signalling to salicylic acid level. ..
- Hünlich M, Tremble S, Begin K, Leavitt B, Ittleman F, VanBuren P. Atrial contractile protein content and function are preserved in patients with coronary artery disease and atrial fibrillation. Coron Artery Dis. 2010;21:357-62 pubmed publisher..Unlike human ventricular dysfunction where contractile protein function is directly affected, the contractile deficit of AF is not the result of alterations in myosin content or contractile protein function. ..
- Sperger D, Fu S, Block L, Munson E. Analysis of composition, molecular weight, and water content variations in sodium alginate using solid-state NMR spectroscopy. J Pharm Sci. 2011;100:3441-3452 pubmed publisher..The technique was found to be selective and sensitive enough to detect these changes in sodium alginate even when diluted with another excipient and compressed into a tablet. ..
- Zhang G, Xiang B, Dong A, Skoda R, Daugherty A, Smyth S, et al. Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Blood. 2011;118:3670-9 pubmed publisher..Together, our data demonstrate important roles of sGC in stimulating platelet activation and in vivo thrombosis and hemostasis, and sGC-dependent and -independent inhibition of platelets by NO donors. ..
- Patel E, Chang L. Synergistic effects of interleukin-7 and pre-T cell receptor signaling in human T cell development. J Biol Chem. 2012;287:33826-35 pubmed..The close association of IL-7R? with CD3? in the pre-TCR complex was illustrated through live imaging confocal fluorescence microscopy. These results demonstrate a direct and cooperative role of IL-7 in pre-TCR signaling. ..
- LaPorta J, Peters T, Weaver S, Merriman K, Hernandez L. Feeding 5-hydroxy-l-tryptophan during the transition from pregnancy to lactation increases calcium mobilization from bone in rats. Domest Anim Endocrinol. 2013;44:176-84 pubmed publisher..048). These results show that increasing 5-HT biosynthesis during the transition from pregnancy to lactation could be a potential therapeutic target to explore for prevention of subclinical and clinical hypocalcemia...
- Funai K, Lodhi I, Spears L, Yin L, Song H, Klein S, et al. Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Diabetes. 2016;65:358-70 pubmed publisher..These results suggest that high-fat feeding and obesity induce CEPT1, which remodels the SR to preserve contractile function at the expense of insulin sensitivity. ..
- Dogan M, Han Y, Delmotte P, Sieck G. TNF? enhances force generation in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2017;312:L994-L1002 pubmed publisher..The results of this study support our hypothesis that TNF? increases force generation in ASM by increasing the number of contractile units (actin-myosin content) contributing to force generation. ..
- Ueda Y, Fukiage C, Shih M, Shearer T, David L. Mass measurements of C-terminally truncated alpha-crystallins from two-dimensional gels identify Lp82 as a major endopeptidase in rat lens. Mol Cell Proteomics. 2002;1:357-65 pubmed..The methodology that allowed accurate mass measurements of proteins eluted from 2D gels should be useful to examine rapidly other post-translational modifications. ..
- Cheng W, Altafaj X, Ronjat M, Coronado R. Interaction between the dihydropyridine receptor Ca2+ channel beta-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling. Proc Natl Acad Sci U S A. 2005;102:19225-30 pubmed..These findings indicate that EC coupling in skeletal muscle involves the interplay of at least two subunits of the DHPR, namely alpha1S and beta1a, interacting with possibly different domains of RyR1. ..
- Villegas R, Martinez N, Lillo J, Pihan P, Hernandez D, Twiss J, et al. Calcium release from intra-axonal endoplasmic reticulum leads to axon degeneration through mitochondrial dysfunction. J Neurosci. 2014;34:7179-89 pubmed publisher..These data reveal a critical and early ER-dependent step during axonal degeneration, providing novel targets for axonal protection in neurodegenerative conditions. ..
- Guo Q, Sebastian L, Sopher B, Miller M, Glazner G, Ware C, et al. Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc Natl Acad Sci U S A. 1999;96:4125-30 pubmed..Our data indicate that neurotrophic factors can interrupt excitotoxic neurodegenerative cascades promoted by PS1 mutations. ..
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