Genomes and Genes
Experts and Doctors on calcium in Germany
Publications409 found, 100 shown here
- Begonja A, Geiger J, Rukoyatkina N, Rauchfuss S, Gambaryan S, Walter U. Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase. Blood. 2007;109:616-8 pubmed..Finally, PKG activation did not stimulate, but rather inhibited, p38 MAP kinase in human platelets. ..
- Foller M, Kasinathan R, Koka S, Huber S, Schuler B, Vogel J, et al. Enhanced susceptibility to suicidal death of erythrocytes from transgenic mice overexpressing erythropoietin. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1127-34 pubmed..In conclusion, circulating erythrocytes from tg6 mice are sensitized to triggers of eryptosis but more resistant to osmotic lysis, properties at least partially due to enhanced Ca(2+) entry and increased K(+) channel activity. ..
- Leuner K, Kazanski V, Müller M, Essin K, Henke B, Gollasch M, et al. Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels. FASEB J. 2007;21:4101-11 pubmed..Hyperforin integrates inhibition of neurotransmitter uptake and neurotrophic property by specific activation of TRPC6 and represents an interesting lead-structure for a new class of antidepressants. ..
- Rey Ares V, Lazarov N, Berg D, Berg U, Kunz L, Mayerhofer A. Dopamine receptor repertoire of human granulosa cells. Reprod Biol Endocrinol. 2007;5:40 pubmed..This suggests a complex role of DA in the regulation of ovarian processes. ..
- Schmid A, Neumayer W, Trulzsch K, Israel L, Imhof A, Roessle M, et al. Cross-talk between type three secretion system and metabolism in Yersinia. J Biol Chem. 2009;284:12165-77 pubmed publisher..enterocolitica. We propose a "load-and-shoot cycle" model to account for the cross-talk between T3SS and metabolism in pathogenic yersiniae. ..
- Westfahl C, Wolf P, Kamphues J. Estimation of inevitable macro mineral losses in amazons (Amazona spp.) as basis for the calculation of maintenance requirement. Arch Anim Nutr. 2009;63:75-85 pubmed publisher..4%), potassium (21.8%) and sodium (4.5%), whereas the calcium and phosphorus content in plasma stayed constant or did not show unidirectional changes in all animals...
- Coulon P, Herr D, Kanyshkova T, Meuth P, Budde T, Pape H. Burst discharges in neurons of the thalamic reticular nucleus are shaped by calcium-induced calcium release. Cell Calcium. 2009;46:333-46 pubmed publisher..We conclude that the activation of LVACC specifically causes CICR via RyR in neurons of the NRT, thereby adding a Ca2+-dependent intracellular route to the mechanisms determining rhythmic oscillatory bursting in this nucleus. ..
- Hirdes W, Dinu C, Bauer C, Boehm U, Schwarz J. Gonadotropin-releasing hormone inhibits ether-à-go-go-related gene K+ currents in mouse gonadotropes. Endocrinology. 2010;151:1079-88 pubmed publisher..In addition, the erg channels are modulated by GnRH by an as-yet unknown signal cascade...
- Walter A, Wiederhold K, Bruns D, Fasshauer D, Sørensen J. Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis. J Cell Biol. 2010;188:401-13 pubmed publisher..Our data are consistent with a model in which the N terminus of the SNARE complex assembles during vesicle priming, followed by Ca(2+)-triggered C-terminal assembly and membrane fusion...
- Blaich A, Pahlavan S, Tian Q, Oberhofer M, Poomvanicha M, Lenhardt P, et al. Mutation of the calmodulin binding motif IQ of the L-type Ca(v)1.2 Ca2+ channel to EQ induces dilated cardiomyopathy and death. J Biol Chem. 2012;287:22616-25 pubmed publisher..Treatment of mice with metoprolol and captopril reduced DCM in Ca(v)1.2(I1624E) hearts at day 10. We conclude that mutation of the IQ motif to IE leads to dilated cardiomyopathy and death. ..
- Towhid S, Schmidt E, Tolios A, Münzer P, Schmid E, Borst O, et al. Stimulation of platelet death by vancomycin. Cell Physiol Biochem. 2013;31:102-12 pubmed publisher..Activation and cell membrane scrambling required the presence of Ca(2+), but not activation of caspases. Vancomycin exposure leads to platelet activation and apoptosis. ..
- Harren K, Tudzynski B. Cch1 and Mid1 are functionally required for vegetative growth under low-calcium conditions in the phytopathogenic ascomycete Botrytis cinerea. Eukaryot Cell. 2013;12:712-24 pubmed publisher..cinerea. ..
- Della Bruna R, Pinet F, Corvol P, Kurtz A. Opposite regulation of renin gene expression by cyclic AMP and calcium in isolated mouse juxtaglomerular cells. Kidney Int. 1995;47:1266-73 pubmed..Moreover, in these acute experiments there appears to be no obligatory link between the secretion and the expression of renin, suggesting that both parameters are separately regulated. ..
- Kohler M, Burnashev N, Sakmann B, Seeburg P. Determinants of Ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing. Neuron. 1993;10:491-500 pubmed..In the TM1 unedited form of GluR6, Ca2+ permeability is less dependent on the presence of either Q or R in TM2. Thus Ca2+ permeability of kainate receptor channels can vary, depending on editing of both TM1 and TM2. ..
- Kohfeldt E, Maurer P, Vannahme C, Timpl R. Properties of the extracellular calcium binding module of the proteoglycan testican. FEBS Lett. 1997;414:557-61 pubmed..No clear evidence was obtained for collagen binding, indicating that EC modules found in different proteins may not share similar functions. ..
- Fleming I, Bauersachs J, Schafer A, Scholz D, Aldershvile J, Busse R. Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1999;96:1123-8 pubmed..Thus, isometric contraction activates eNOS via a Ca2+-independent, tyrosine kinase inhibitor-sensitive pathway and, like shear stress, seems to be an independent determinant of mechanically induced NO formation. ..
- O CONNOR V, El Far O, Bofill Cardona E, Nanoff C, Freissmuth M, Karschin A, et al. Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling. Science. 1999;286:1180-4 pubmed..These results reveal a novel mechanism of presynaptic modulation in which Ca(2+)-calmodulin is required to release G protein betagamma subunits from the C-tail of group III mGluRs in order to mediate glutamatergic autoinhibition. ..
- Kurtz R, Durr V, Egelhaaf M. Dendritic calcium accumulation associated with direction-selective adaptation in visual motion-sensitive neurons in vivo. J Neurophysiol. 2000;84:1914-23 pubmed..Thus the potential role of calcium in motion adaptation depends on stimulation parameters and cell class...
- Kübler D. Ecto-protein kinase substrate p120 revealed as the cell-surface-expressed nucleolar phosphoprotein Nopp140: a candidate protein for extracellular Ca2+-sensing. Biochem J. 2001;360:579-87 pubmed..Our results indicate that, in addition to nucleolin, a further nucleolar protein, which was considered initially to be strictly intracellular, is identified as a cell-surface phosphoprotein. ..
- Matsunaga S, Harmon S, Gohlsch B, Ohlendieck K, Pette D. Inactivation of sarcoplasmic reticulum Ca(2+)-atpase in low-frequency stimulated rat muscle. J Muscle Res Cell Motil. 2001;22:685-91 pubmed..The relatively slow recovery of Ca(2+)-ATPase activity suggests that de novo synthesis of the enzyme may be necessary to re-attain normal activity. ..
- ROSGEN J, Hinz H. Phase diagrams: a graphical representation of linkage relations. J Mol Biol. 2003;328:255-71 pubmed
- zu Heringdorf D, Vincent M, Lipinski M, Danneberg K, Stropp U, Wang D, et al. Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1). Cell Signal. 2003;15:677-87 pubmed..Co-expression of S1P(1) with S1P(3), but not S1P(2), reversed the inhibitory effect of S1P(1), furthermore suggesting a specific interplay of S1P receptor subtypes usually found within a single cell type. ..
- Fischer M, Reeh P, Sauer S. Proton-induced calcitonin gene-related peptide release from rat sciatic nerve axons, in vitro, involving TRPV1. Eur J Neurosci. 2003;18:803-10 pubmed..Axonal sensitivity to and sensitization by protons may be a pathophysiological mechanism involved in certain peripheral neuropathies. ..
- Speidel D, Varoqueaux F, Enk C, Nojiri M, Grishanin R, Martin T, et al. A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. J Biol Chem. 2003;278:52802-9 pubmed..The abundance of CAPS proteins in synaptic terminals indicates that they may also be important for neuronal functions that are not exclusively related to LDCV exocytosis. ..
- Saunders R, Scheiner Bobis G. Ouabain stimulates endothelin release and expression in human endothelial cells without inhibiting the sodium pump. Eur J Biochem. 2004;271:1054-62 pubmed..The data also confirm that it is not a global inhibition of the sodium pump that is involved in the mechanism of action of this cardiac glycoside. ..
- Kukley M, Stausberg P, Adelmann G, Chessell I, Dietrich D. Ecto-nucleotidases and nucleoside transporters mediate activation of adenosine receptors on hippocampal mossy fibers by P2X7 receptor agonist 2'-3'-O-(4-benzoylbenzoyl)-ATP. J Neurosci. 2004;24:7128-39 pubmed..Thus, the present study casts doubts on the neuronal localization of P2X7 receptors in rodent hippocampus. ..
- Levchenko V, Konrad K, Dietrich P, Roelfsema M, Hedrich R. Cytosolic abscisic acid activates guard cell anion channels without preceding Ca2+ signals. Proc Natl Acad Sci U S A. 2005;102:4203-8 pubmed..6 microM ABA. Our studies point to an ABA pathway initiated by ABA binding to a cytosolic receptor that within seconds activates anion channels, and in turn, leads to depolarization of the plasma membrane. ..
- Meyer J, Preyer S, Hofmann S, Gummer A. Tonic mechanosensitivity of outer hair cells after loss of tip links. Hear Res. 2005;202:97-113 pubmed..These experiments imply an intracellular, calcium-dependent gating mechanism for hair-cell transducer channels. ..
- Gostner A, Schaffer V, Theis S, Menzel T, Luhrs H, Melcher R, et al. Effects of isomalt consumption on gastrointestinal and metabolic parameters in healthy volunteers. Br J Nutr. 2005;94:575-81 pubmed..This suggests that isomalt is well tolerated and that consumption of isomalt does not impair metabolic function or induce hypercalciuria. In addition, the study data indicate that isomalt could be useful in improving bowel function...
- Martin A, Kuhlmann C, Trossbach S, Jaeger S, Waldron E, Roebroek A, et al. The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors. J Biol Chem. 2008;283:12004-13 pubmed publisher..These results provide new insights into the mechanism of a tPA-induced, LRP1-mediated gating mechanism for NMDA receptors. ..
- Grotemeier A, Alers S, Pfisterer S, Paasch F, Daubrawa M, Dieterle A, et al. AMPK-independent induction of autophagy by cytosolic Ca2+ increase. Cell Signal. 2010;22:914-25 pubmed publisher..We suggest that apart from reported AMPK-dependent regulation of autophagic degradation, an AMPK-independent pathway triggers Ca(2+)-mediated autophagy, involving the PI(3)P-effector protein WIPI-1 and LC3...
- Oliveira E, Pippow A, Salgado V, Buschges A, Schmidt J, Kloppenburg P. Cholinergic currents in leg motoneurons of Carausius morosus. J Neurophysiol. 2010;103:2770-82 pubmed publisher..Distinct concentration-response relations of I(ACh1) and I(ACh2) for these ligands indicated that they are mediated by different types of nicotinic acetylcholine receptors. ..
- Hoyer D, Grönke S, Frank K, Addicks K, Wettschureck N, Offermanns S, et al. Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes. Mol Cell Biochem. 2010;341:235-44 pubmed publisher..6, annexin A7, and sorcin. ..
- Rosenbaum S, Kreft S, Etich J, Frie C, Stermann J, Grskovic I, et al. Identification of novel binding partners (annexins) for the cell death signal phosphatidylserine and definition of their recognition motif. J Biol Chem. 2011;286:5708-16 pubmed publisher..Hence, the individual annexin repertoire bound to the cell surface of dying cells may fulfil opsonin-like function in cell death recognition. ..
- Pettelkau J, Schröder T, Ihling C, Olausson B, Kölbel K, Lange C, et al. Structural Insights into retinal guanylylcyclase-GCAP-2 interaction determined by cross-linking and mass spectrometry. Biochemistry. 2012;51:4932-49 pubmed publisher..On the basis of the distance constraints imposed by the cross-links, we were able to create a structural model of the calcium-loaded complex between myristoylated GCAP-2 and the GC peptide. ..
- Zbidah M, Lupescu A, Herrmann T, Yang W, Foller M, Jilani K, et al. Effect of honokiol on erythrocytes. Toxicol In Vitro. 2013;27:1737-45 pubmed publisher..In conclusion, honokiol triggers suicidal erythrocyte death or eryptosis, an effect at least in part due to stimulation of Ca(2+) entry and ceramide formation. ..
- Brandherm I, Disse J, Zeuschner D, Gerke V. cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2. Blood. 2013;122:1042-51 pubmed publisher..Thus, complex formation of AnxA2 with S100A10 is a central regulatory mechanism in the acute release of VWF in response to cAMP-elevating agonists. ..
- Llorens F, ThÃ¼ne K, Sikorska B, Schmitz M, Tahir W, FernÃ¡ndez Borges N, et al. Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease. Acta Neuropathol Commun. 2017;5:35 pubmed publisher..Altogether our work indicates that unbalanced Calpain-Cathepsin activation is a relevant contributor to the pathogenesis of sCJD at multiple molecular levels and a potential target for therapeutic intervention. ..
- Harteneck C, Obukhov A, Zobel A, Kalkbrenner F, Schultz G. The Drosophila cation channel trpl expressed in insect Sf9 cells is stimulated by agonists of G-protein-coupled receptors. FEBS Lett. 1995;358:297-300 pubmed..Although the identity of the G-proteins and of possible second messengers involved need to be clarified, it is clear that trpl represents a receptor/G-protein regulated cation channel. ..
- Bondy B, Klages U, Muller Spahn F, Hock C. Cytosolic free [Ca2+] in mononuclear blood cells from demented patients and healthy controls. Eur Arch Psychiatry Clin Neurosci. 1994;243:224-8 pubmed..However, there might be some difference in [Ca2+]i values between early- and late-onset AD, which could have pathophysiological importance. ..
- Obukhov A, Harteneck C, Zobel A, Harhammer R, Kalkbrenner F, Leopoldt D, et al. Direct activation of trpl cation channels by G alpha11 subunits. EMBO J. 1996;15:5833-8 pubmed..Thus, G proteins of the Gq subfamily may induce Ca2+ entry not only indirectly via store-operated mechanisms but also by directly stimulating cation channels. ..
- Steinlein O, Magnusson A, Stoodt J, Bertrand S, Weiland S, Berkovic S, et al. An insertion mutation of the CHRNA4 gene in a family with autosomal dominant nocturnal frontal lobe epilepsy. Hum Mol Genet. 1997;6:943-7 pubmed..Comparison of the two mutations identified so far in families with ADNFLE illustrates that different mutations can result in similar phenotypes. ..
- Koegel H, Alzheimer C. Expression and biological significance of Ca2+-activated ion channels in human keratinocytes. FASEB J. 2001;15:145-154 pubmed..hSK4 might thus play a role in linking changes in membrane potential to the biological fate of keratinocytes. ..
- Schafer M, Bahde D, Bosche B, Ladilov Y, Schafer C, Piper H, et al. Modulation of early [Ca2+]i rise in metabolically inhibited endothelial cells by xestospongin C. Am J Physiol Heart Circ Physiol. 2001;280:H1002-10 pubmed..When this occurs, the ER Ca(2+) store is discharged by opening of the Ins(3)P-sensitive release channel. Xestospongin C can effectively suppress the early [Ca(2+)](i) rise in metabolically inhibited endothelial cells...
- Korn T, Toyka K, Hartung H, Jung S. Suppression of experimental autoimmune neuritis by leflunomide. Brain. 2001;124:1791-802 pubmed..In summary, leflunomide suppresses EAN efficiently and may constitute a promising therapy for immune-mediated neuropathies. ..
- Sasaki T, Knyazev P, Cheburkin Y, Göhring W, Tisi D, Ullrich A, et al. Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains. J Biol Chem. 2002;277:44164-70 pubmed..Mutagenesis of some residues in this patch reduces Gas6-LG binding to the extracellular domain of Axl as well as Axl activation in glioblastoma cells, identifying a component of the receptor-binding site of Gas6. ..
- Sørensen J, Fernandez Chacon R, Sudhof T, Neher E. Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+. J Gen Physiol. 2003;122:265-76 pubmed..Single amperometric fusion events were unchanged. We conclude that Ca2+-dependent phospholipid binding to synaptotagmin 1 mirrors the intracellular Ca2+ dependence of exocytosis. ..
- Escher S, Forssmann U, Frimpong Boateng A, Adermann K, Vakili J, Sticht H, et al. Functional analysis of chemically synthesized derivatives of the human CC chemokine CCL15/HCC-2, a high affinity CCR1 ligand. J Pept Res. 2004;63:36-47 pubmed..This study demonstrates that specific protein residues in chemokines, which contribute to receptor-ligand interaction, vary significantly between chemokines and cannot be extrapolated using data from functionally related chemokines. ..
- Schuh K, Cartwright E, Jankevics E, Bundschu K, Liebermann J, Williams J, et al. Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility. J Biol Chem. 2004;279:28220-6 pubmed
- Geiselhöringer A, Werner M, Sigl K, Smital P, Wörner R, Acheo L, et al. IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase. EMBO J. 2004;23:4222-31 pubmed..We conclude that cGMP-dependent relaxation of hormone receptor-triggered smooth muscle contraction essentially depends on the interaction of cGKI-IRAG with IP(3)RI. ..
- Haroon M, Fatima A, Schöler S, Gieseler A, Horn T, Kirches E, et al. Minocycline, a possible neuroprotective agent in Leber's hereditary optic neuropathy (LHON): studies of cybrid cells bearing 11,778 mutation. Neurobiol Dis. 2007;28:237-50 pubmed..In relation with its high safety profile, these results would suggest minocycline as a promising neuroprotective agent in LHON. ..
- Schwarz E, Kummerow C, Wenning A, Wagner K, Sappok A, Waggershauser K, et al. Calcium dependence of T cell proliferation following focal stimulation. Eur J Immunol. 2007;37:2723-33 pubmed..We conclude that very small changes in [Ca(2+)](i) can dramatically change the ratio between proliferation and apoptosis, thus keeping the balance between overshooting and inefficient immune responses. ..
- Batistic O, Kudla J. Plant calcineurin B-like proteins and their interacting protein kinases. Biochim Biophys Acta. 2009;1793:985-92 pubmed publisher..The occurrence of CBL and CIPK proteins appears not to be restricted to the plant kingdom raising the question about the function of these Ca2+ decoding components in non-plant species. ..
- Fendrich V, Waldmann J, Feldmann G, Schlosser K, König A, Ramaswamy A, et al. Unique expression pattern of the EMT markers Snail, Twist and E-cadherin in benign and malignant parathyroid neoplasia. Eur J Endocrinol. 2009;160:695-703 pubmed publisher..Loss of E-cadherin and change of the expression pattern of Snail and Twist together should result in an en bloc resection or a close follow-up. ..
- KÃ¶enig A, Linhart T, Schlengemann K, Reutlinger K, Wegele J, Adler G, et al. NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells. Gastroenterology. 2010;138:1189-99.e1-2 pubmed publisher..Our study uncovers a novel mechanism regulating cell growth and identifies the NFAT/ELK complex as modulators of early stages of mitogen-stimulated proliferation in pancreatic cancer cells. ..
- Haisch L, Almeida J, Abreu da Silva P, Schlingmann K, Konrad M. The role of tight junctions in paracellular ion transport in the renal tubule: lessons learned from a rare inherited tubular disorder. Am J Kidney Dis. 2011;57:320-30 pubmed publisher..We also review recent advances in understanding the electrophysiologic function of claudin-16 and -19 in the thick ascending limb of the loop of Henle and implications for ion homeostasis in the human body. ..
- Muth S, Fries A, Gimpl G. Cholesterol-induced conformational changes in the oxytocin receptor. Biochem J. 2011;437:541-53 pubmed publisher..Overall, cholesterol induced both a changed orientation and a decreased distance of the receptor-bound ligands, suggesting a more compact receptor state in association with cholesterol. ..
- Radhakrishnan K, Kamp M, Siapich S, Hescheler J, Lüke M, Schneider T. Ca(v)2.3 Ca2+ channel interacts with the G1-subunit of V-ATPase. Cell Physiol Biochem. 2011;27:421-32 pubmed publisher..The results suggest that v-ATPase interacts physically and also functionally with Ca(v)2.3. This is the first demonstration of association of Ca(v)2.3 C-terminus with a protein complex which is involved in transmembrane signalling. ..
- Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, et al. BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival. Cell Death Differ. 2016;23:358-68 pubmed publisher..These results suggest that BI-1 has a major role in the functioning of the adaptive immune system by regulating intracellular Ca(2+) homeostasis in lymphocytes. ..
- Zörnig M, Busch G, Beneke R, Gulbins E, Lang F, Ma A, et al. Survival and death of prelymphomatous B-cells from N-myc/bcl-2 double transgenic mice correlates with the regulation of intracellular Ca2+ fluxes. Oncogene. 1995;11:2165-74 pubmed..We hypothesize therefore that the regulation of intracellular Ca2+ concentrations represent one important parameter in the oncogenic cooperation between bcl-2 and N-myc. ..
- Trautmann A, Feuerstein B, Ernst N, Brocker E, Klein C. Heterotypic cell-cell adhesion of human mast cells to fibroblasts. Arch Dermatol Res. 1997;289:194-203 pubmed
- Guse A, da Silva C, Weber K, Armah C, Ashamu G, Schulze C, et al. 1-(5-phospho-beta-D-ribosyl)2'-phosphoadenosine 5'-phosphate cyclic anhydride induced Ca2+ release in human T-cell lines. Eur J Biochem. 1997;245:411-7 pubmed..Immunol. 155, 3353-3359]. Control experiments suggest that the results were neither due to Ca2+ contaminations in the cADP-Rib preparation nor to catabolism of cAdo(2')P(5')PP-Rib to cADP-Rib. ..
- Zwick E, Daub H, Aoki N, Yamaguchi Aoki Y, Tinhofer I, Maly K, et al. Critical role of calcium- dependent epidermal growth factor receptor transactivation in PC12 cell membrane depolarization and bradykinin signaling. J Biol Chem. 1997;272:24767-70 pubmed..Taken together, our results establish calcium-dependent EGFR transactivation as a signaling mechanism mediating activation of the Ras/mitogen-activated protein kinase pathway in neuronal cell types. ..
- Schönherr R, Lober K, Heinemann S. Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin. EMBO J. 2000;19:3263-71 pubmed..Co-expression experiments of wild-type and mutant channels revealed that the binding of one CaM molecule per channel complex is sufficient for channel inhibition. ..
- Bolz S, Pieperhoff S, de Wit C, Pohl U. Intact endothelial and smooth muscle function in small resistance arteries after 48 h in vessel culture. Am J Physiol Heart Circ Physiol. 2000;279:H1434-9 pubmed..It is concluded that vascular function can be preserved while maintaining vessels in culture. Thus it is possible to utilize protocols that require long-term treatment...
- Wissenbach U, Bödding M, Freichel M, Flockerzi V. Trp12, a novel Trp related protein from kidney. FEBS Lett. 2000;485:127-34 pubmed
- Hunold P, Schmermund A, Seibel R, Gronemeyer D, Erbel R. Prevalence and clinical significance of accidental findings in electron-beam tomographic scans for coronary artery calcification. Eur Heart J. 2001;22:1748-58 pubmed..Profound knowledge of the radiological differential diagnosis of the thoracic organs is necessary for reporting electron-beam tomographic scans, in order to avoid misdiagnosis and to receive a high quality interpretation. ..
- Panther E, Idzko M, Herouy Y, Rheinen H, Gebicke Haerter P, Mrowietz U, et al. Expression and function of adenosine receptors in human dendritic cells. FASEB J. 2001;15:1963-70 pubmed..These effects can be explained by differential expression of adenosine receptor subtypes. ..
- Knebel D, Sieber M, Reichelt R, Galla H, Amrein M. Fluorescence light microscopy of pulmonary surfactant at the air-water interface of an air bubble of adjustable size. Biophys J. 2002;83:547-55 pubmed..In the lung, such multilayer phase acts as a reservoir that guarantees a full molecular coverage of the alveolar interface during the breathing cycle and provides mechanical stability to the film. ..
- Ignatov A, Lintzel J, Kreienkamp H, Schaller H. Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway. Biochem Biophys Res Commun. 2003;311:329-36 pubmed..The antiapoptotic effect of S1P required activation of sphingosine kinase and was accompanied by an increase in MAP-kinase phosphorylation. ..
- Wegener J, Schulla V, Lee T, Koller A, Feil S, Feil R, et al. An essential role of Cav1.2 L-type calcium channel for urinary bladder function. FASEB J. 2004;18:1159-61 pubmed..These results show that the Cav1.2 Ca2+ channel is essential for normal bladder function. The Rho-kinase and Ca2+-release pathways cannot compensate the lack of the L-type Ca2+ channel. ..
- Komolov K, Zinchenko D, Churumova V, Vaganova S, Weiergräber O, Senin I, et al. One of the Ca2+ binding sites of recoverin exclusively controls interaction with rhodopsin kinase. Biol Chem. 2005;386:285-9 pubmed..Structural changes resulting from Ca(2+)-occupation of EF-hand 2 in myristoylated and non-myristoylated recoverin variants are discussed in terms of critical conditions required for biological activity. ..
- Lang F, Lang K, Lang P, Huber S, Wieder T. Mechanisms and significance of eryptosis. Antioxid Redox Signal. 2006;8:1183-92 pubmed..Conditions with excessive eryptosis include iron deficiency, lead or mercury intoxication, sickle cell anemia, thalassemia, glucose 6- phosphate dehydrogenase deficiency, malaria, and infection with hemolysin-forming pathogens. ..
- Desch M, Sigl K, Hieke B, Salb K, Kees F, Bernhard D, et al. IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation. Cardiovasc Res. 2010;86:496-505 pubmed publisher..IRAG signalling does not modulate basal tone but might be important for blood pressure regulation under pathophysiological conditions. ..
- Smith E, Blass G, Lewin G, Park T. Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P. Mol Pain. 2010;6:29 pubmed publisher..These results illustrate that it is altered dorsal horn connectivity of nociceptors that underlies the lack of itch and pain-related behavior in the naked mole-rat...
- Wiemuth D, Grunder S. A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC). J Biol Chem. 2010;285:30404-10 pubmed publisher..Collectively, our results suggest that rBLINaC is opened by an unknown ligand whereas mBLINaC is a constitutively open epithelial Na(+) channel. ..
- Yang L, Kockskamper J, Khan S, Suarez J, Walther S, Doleschal B, et al. cAMP- and Ca²(+) /calmodulin-dependent protein kinases mediate inotropic, lusitropic and arrhythmogenic effects of urocortin 2 in mouse ventricular myocytes. Br J Pharmacol. 2011;162:544-56 pubmed publisher..This enhancement was accompanied by Ca²(+)-dependent arrhythmogenic effects mediated by PKA and CaMKII. ..
- Paskauskas S, Parseliunas A, Kerkadze V, Nobiling R, Schmidt J, Ryschich E. Blockade of leukocyte haptokinesis and haptotaxis by ketoprofen, diclofenac and SC-560. BMC Immunol. 2011;12:64 pubmed publisher..NSAID strongly supress leukocyte migration. The results of the present study may have important clinical implications since blockade of leukocyte migration can be achieved after topical application of NSAID. ..
- Shaik N, Lupescu A, Lang F. Inhibition of suicidal erythrocyte death by probucol. J Cardiovasc Pharmacol. 2013;61:120-6 pubmed publisher..In conclusion, probucol blunts cell membrane scrambling after energy depletion and oxidative stress, effects primarily because of interference with the scrambling effects of increased cytosolic Ca(2+) concentration. ..
- Bissinger R, Malik A, Bouguerra G, Zhou Y, Singh Y, AbbÃ¨s S, et al. Triggering of Suicidal Erythrocyte Death by the Antibiotic Ionophore Nigericin. Basic Clin Pharmacol Toxicol. 2016;118:381-9 pubmed publisher..Nigericin triggers eryptosis, an effect paralleled by ROS formation, in part dependent on stimulation of Ca(2+) entry, and involving the cariporide-sensitive Na(+)/H(+) exchanger. ..
- Viero C, Wegener S, Scholz A, Ruppenthal S, Tian Q, Tabellion W, et al. Endothelin-1-induced remodelling of murine adult ventricular myocytes. Cell Calcium. 2016;59:41-53 pubmed publisher..We therefore conclude that chronic stimulation of cardiac myocytes by H-GÎ±qPCRs induces cellular remodelling of Ca(2+) cycling with altered PKCÎ³ expression and promotion of arrhythmogenic cellular responses. ..
- Bauer M, Retzer M, Wilde J, Maschberger P, Essler M, Aepfelbacher M, et al. Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets. Blood. 1999;94:1665-72 pubmed
- Pfitzer G. Invited review: regulation of myosin phosphorylation in smooth muscle. J Appl Physiol (1985). 2001;91:497-503 pubmed..Hence, smooth muscle tone appears to be regulated by a network of activating and inactivating intracellular signaling cascades...
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